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Sequences

Sequence NM_025109

TCCTTTCCTCACTGCACGCTCTTGCCCCTCCTCTTTTCTCTCCTGCCCGTGTTCTTCCCGCCGCCTGACCTGGCCCGCCCGCCTTTCCAGTCTGGCCGGG CGGGGGCCTGAAGCACGGCGGCTCGGGCCGTGGGACCGTGTTCACACCCTTTCCAGAAATTCTTGGCTGGTAACCGCGAAACCGACTGGAGCAGGAGCTG GGAGAACTGGAGAAAACTGCTCTAATCTCACTTGACTCCAGCTAGGAGCTGATGCTGCATCGTAATAACATTTGCAGAGCGCTTTCACAGGCGCTGGAGT GACTTGTCTGAGATTCCTCCAGAACTGAGCCCTTTGTTGGAACCATACCCCAGCCCATGGTCCCATGACTAGGTGGATAGTACTCCTTGTACCTCCTGCA ACCCAGAACCCTGGCTGACCACTTTGAAGGAGGATGCTCCAGCAGGTCAATGGCCACAATCCGGGGTCTGATGGCCAAGCCAGGGAGTACCTCAGAGAAG ACCTGCAGGAGTTCCTGGGTGGGGAGGTCCTGCTGTACAAACTGGATGACCTCACCAGGGTGAATCCTGTGACACTAGAGACAGTCCTGAGGTGCCTGCA GGCCCGGTACATGGCAGACACATTCTACACCAATGCTGGCTGCACCCTGGTAGCCTTGAACCCCTTCAAGCCTGTTCCTCAGCTCTACTCGCCCGAGCTA ATGAGAGAGTACCATGCTGCGCCTCAGCCCCAGAAACTGAAGCCCCATGTGTTCACTGTGGGTGAACAGACCTACAGGAATGTCAAGAGCCTGATTGAAC CAGTCAACCAGTCTATTGTTGTCAGTGGAGAGAGTGGTGCTGGAAAGACATGGACGTCTCGCTGCCTAATGAAGTTCTATGCTGTGGTGGCCACCTCACC TGCATCTTGGGAGAGCCACAAGATTGCAGAGAGGATAGAACAGAGGATCCTGAACTCCAACCCTGTCATGGAAGCTTTTGGGAATGCGTGTACACTGAGG AATAACAACAGCAGTCGCTTTGGGAAGTTCATCCAGCTCCAGCTGAACAGGGCTCAGCAAATGACTGGAGCCGCAGTCCAGACCTACCTCCTAGAGAAAA CTCGAGTGGCCTGCCAGGCTTCCAGTGAGAGGAACTTCCACATCTTCTATCAGATTTGCAAAGGAGCCAGTGAGGACGAGAGGCTCCAGTGGCACCTTCC TGAGGGAGCTGCCTTCTCCTGGCTGCCCAACCCAGAGAGGAGCTTAGAAGAGGATTGTTTTGAGGTGACCAGAGAGGCCATGCTCCATTTGGGCATTGAC ACCCCTACCCAGAACAACATCTTTAAGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGC CGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGC AGGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGAC TGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTG ACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTT CCCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCC AAAGGGCTCCCTGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACCTCTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAG CCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGCAGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGG GCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGAGGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTC ATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCTGCATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCA GAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACACTTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCT CCTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATACGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGC CTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACAAGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAA AGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAACCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACA CAGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCTTGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAG ACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATGCACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCC AGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGTCAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTT CACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTACACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAA GTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTTATTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATT TAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGTA

refseq_MYOHD1.F2 (forward primer)
refseq_MYOHD1.R2 (reverse primer)
Single exon skipping

Frame 0

SFPHCTLLPLLFSLLPVFFPPPDLARPPFQSGR AGA*STAARAVGPCSHPFQKFLAGNRETDWSRSW ENWRKLL*SHLTPARS*CCIVITFAERFHRRWS DLSEIPPELSPLLEPYPSPWSHD*VDSTPCTSC NPEPWLTTLKEDAPAGQWPQSGV*WPSQGVPQRR PAGVPGWGGPAVQTG*PHQGESCDTRDSPEVPA GPVHGRHILHQCWLHPGSLEPLQACSSALLARA NERVPCCASAPETEAPCVHCG*TDLQECQEPD*T SQPVYCCQWREWCWKDMDVSLPNEVLCCGGHLT CILGEPQDCREDRTEDPELQPCHGSFWECVYTE E*QQQSLWEVHPAPAEQGSANDWSRSPDLPPREN SSGLPGFQ*EELPHLLSDLQRSQ*GREAPVAPS *GSCLLLAAQPREELRRGLF*GDQRGHAPFGH* HPYPEQHL*GPSWTAAPWQYPVCCLRG*SPALPA DG*CQVLCQDGSLAAGAPRGRAAGDGAD*NHQG RQTAAGVPEALRPSRV*HP*RLPGQTDLCAVV* LAGISDQQQHLCRHRLVDHFHRPAGCVWI*IIS* QQSGTVVHQLRQ*EAPAGGLWPRGDHPYQCCWL PHPGLSPKLCRTIQVTKKASSLHILWPRQPISC QRAP*MVSTQRGSHA*TSHPGHSPHSAGPNSGSS HNW*LG*GHASPHALWQDQGVHD*LYAGASGMW ACPGAGAVCPLHPGWLEATPAPRAGAAVAGRHA HPGSHSFLVNSETHPEAACSCHSHQACMAEVENQ NGLPCC*RAGWCGRKTLLSSSLFPEHLAAADQA PGGNNPPLAPGTGPGQYGYGCRQLSEEISGLGL PPAPQGQPQ*LHCPDSTRPGWCHVHPSAASGIDK VSLQKVSTAVC*HLP*TFTLQHYRL*SDSAGKT QADPRDLFCLHWAGVILGAFVSTRPFPAPCLAK DI*SAHSCQTIPTVLQMHMNNSDGSSLRPRAPCP VRQWAWGSRLHQALMVSGLVVTKSGLRNIRATF HYLHRSNSAAVMTVCHYTGDPNST*ALLEENSQ SWPKIGAGIWAGKNLVVISFKKEQNFSI*LVDLF NVISNN*IMNNAM

Frame 1

PFLTARSCPSSFLSCPCSSRRLTWPARLSSLAG RGPEARRLGPWDRVHTLSRNSWLVTAKPTGAGA GRTGENCSNLT*LQLGADAAS**HLQSAFTGAGV TCLRFLQN*ALCWNHTPAHGPMTRWIVLLVPPA TQNPG*PL*RRMLQQVNGHNPGSDGQAREYLRE DLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQ ARYMADTFYTNAGCTLVALNPFKPVPQLYSPEL MREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIE PVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSP ASWESHKIAERIEQRILNSNPVMEAFGNACTLR NNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEK TRVACQASSERNFHIFYQICKGASEDERLQWHLP EGAAFSWLPNPERSLEEDCFEVTREAMLHLGID TPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQ PMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRA GRQQQVFRKPCARAECDTRRDCLAKLIYARLFD WLVSVINSSICADTDSWTTFIGLLDVYGFESFP DNSLEQLCINYANEKLQLEACGLVETIHISAAGF PIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPA KGLPEWCPHSEEATLEPLIQDILHTLPVLTQAA AITGDSAEAMPAPMHCGRTKVFMTDSMLELLECG RARVLEQCARCIQGGWRRHRHREQERQWRAVML IQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRI RMACLAAKELDGVEEKHFSQAPCSLSTSPLQTRL LEAIIRLWPLGLVLANTAMGVGSFQRKLVVWAC LQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSI KFHCRKSPLRYADICPEPSPYSITGFNQILLERH RLIHVTSSAFTGLG*SLVPLFPQGLFLPPALPK TFNQHTAARLFPQCSKCT*TTVTAPAFDPEPRA QCVSGPGVPGYIKH*WCQGW*LPNQG*ETSGPHF TTFTDQTQQQS*LSVTTLGIPIPHKHFWKKTAK VGLKLALEFGLGKILWLFPLKRNKTLVFN*LIY LM*FQTIKL*IMQC

Frame 2

LSSLHALAPPLFSPARVLPAA*PGPPAFPVWPG GGLKHGGSGRGTVFTPFPEILGW*PRNRLEQEL GELEKTALISLDSS*ELMLHRNNICRALSQALE *LV*DSSRTEPFVGTIPQPMVP*LGG*YSLYLLQ PRTLADHFEGGCSSRSMATIRGLMAKPGSTSEK TCRSSWVGRSCCTNWMTSPG*IL*H*RQS*GAC RPGTWQTHSTPMLAAPW*P*TPSSLFLSSTRPS* *ESTMLRLSPRN*SPMCSLWVNRPTGMSRA*LN QSTSLLLSVERVVLERHGRLAA**SSMLWWPPH LHLGRATRLQRG*NRGS*TPTLSWKLLGMRVH*G ITTAVALGSSSSSS*TGLSK*LEPQSRPTS*RK LEWPARLPVRGTSTSSIRFAKEPVRTRGSSGTF LRELPSPGCPTQRGA*KRIVLR*PERPCSIWALT PLPRTTSLRS*LDCCTLAISSLLPPRMKPSPAS RWMMPSTLSGRQPRCWGSQRTCCWRWCRLEPSG QADSSRCSGSPAPEPSVTPVETAWPN*SMRGCLT GWYQ*STAASVQTPTRGPLS*ACWMCMDLNHFL TTVWNSCASTTPMRSSSWRPVASWRPSISVLLA SPSGSLTETL*NDTSY*EGFILAHPLAPTAHILP KGSLNGVHTARKPRLNLSSRTFSTLCRS*LRQQ P*LVTRLRPCQPPCTVAGPRCS*LTLCWSFWNV GVPGCWSSVPAASRVAGGDTGTESRSGSGGPSCS SRQPFVPG*LGNTSRGCMQLPQSSSVHGRSGES EWPALLLKSWMVWKKNTSLKLPVP*APRRCRPG SWRQ*SASGPWDWSWPIRLWV*AAFRGN*WSGLA SSSPGAAPVATLSRQHKTRLVSRPSERCLRDR* SFTAESLHCGMLTSALNLHPTALQALIRFCWKD TG*ST*PLLPSLGWGDPWCLCFHKAFSCPLPCQR HLISTQLPDYSHSAPNAHEQQ*RLQPSTQSPVP SASVGLGFQATSSTDGVRAGSYQIRVKKHQGHI SLPSQIKLSSSHDCLSLHWGSQFHISTFGRKQPK LA*NWRWNLGWEKSCGYFL*KGTKL*YLIS*FI *CNFKQLNYE*CNV

Sequence NM_001033579

TCCTTTCCTCACTGCACGCTCTTGCCCCTCCTCTTTTCTCTCCTGCCCGTGTTCTTCCCGCCGCCTGACCTGGCCCGCCCGCCTTTCCAGTCTGGCCGGG CGGGGGCCTGAAGCACGGCGGCTCGGGCCGTGGGACCGTGTTCACACCCTTTCCAGAAATTCTTGGCTGGTAACCGCGAAACCGACTGGAGCAGGAGCTG GGAGAACTGGAGAAAACTGCTCTAATCTCACTTGACTCCAGCTAGGAGCTGATGCTGCATCGTAATAACATTTGCAGAGCGCTTTCACAGGCGCTGGAGT GACTTGTCTGAGATTCCTCCAGAACTGAGCCCTTTGTTGGAACCATACCCCAGCCCATGGTCCCATGACTAGGTGGATAGTACTCCTTGTACCTCCTGCA ACCCAGAACCCTGGCTGACCACTTTGAAGGAGGATGCTCCAGCAGGTCAATGGCCACAATCCGGGGTCTGATGGCCAAGCCAGGGAGTACCTCAGAGAAG ACCTGCAGGAGTTCCTGGGTGGGGAGGTCCTGCTGTACAAACTGGATGACCTCACCAGGGTGAATCCTGTGACACTAGAGACAGTCCTGAGGTGCCTGCA GGCCCGGTACATGGCAGACACATTCTACACCAATGCTGGCTGCACCCTGGTAGCCTTGAACCCCTTCAAGCCTGTTCCTCAGCTCTACTCGCCCGAGCTA ATGAGAGAGTACCATGCTGCGCCTCAGCCCCAGAAACTGAAGCCCCATGTGTTCACTGTGGGTGAACAGACCTACAGGAATGTCAAGAGCCTGATTGAAC CAGTCAACCAGTCTATTGTTGTCAGTGGAGAGAGTGGTGCTGGAAAGACATGGACGTCTCGCTGCCTAATGAAGTTCTATGCTGTGGTGGCCACCTCACC TGCATCTTGGGAGAGCCACAAGATTGCAGAGAGGATAGAACAGAGGATCCTGAACTCCAACCCTGTCATGGAAGCTTTTGGGAATGCGTGTACACTGAGG AATAACAACAGCAGTCGCTTTGGGAAGTTCATCCAGCTCCAGCTGAACAGGGCTCAGCAAATGACTGGAGCCGCAGTCCAGACCTACCTCCTAGAGAAAA CTCGAGTGGCCTGCCAGGCTTCCAGTGAGAGGAACTTCCACATCTTCTATCAGATTTGCAAAGGAGCCAGTGAGGACGAGAGGCTCCAGTGGCACCTTCC TGAGGGAGCTGCCTTCTCCTGGCTGCCCAACCCAGAGAGGAGCTTAGAAGAGGATTGTTTTGAGGTGACCAGAGAGGCCATGCTCCATTTGGGCATTGAC ACCCCTACCCAGAACAACATCTTTAAGGTCCTAGCTGGACTGCTGCACCTTGGCAATATCCAGTTTGCTGCCTCCGAGGATGAAGCCCAGCCCTGCCAGC CGATGGATGATGCCAAGTACTCTGTCAGGACGGCAGCCTCGCTGCTGGGGCTCCCAGAGGACGTGCTGCTGGAGATGGTGCAGATTAGAACCATCAGGGC AGGCAGACAGCAGCAGGTGTTCCGGAAGCCCTGCGCCCGAGCCGAGTGTGACACCCGTAGAGACTGCCTGGCCAAACTGATCTATGCGCGGTTGTTTGAC TGGCTGGTATCAGTGATCAACAGCAGCATCTGTGCAGACACCGACTCGTGGACCACTTTCATAGGCCTGCTGGATGTGTATGGATTTGAATCATTTCCTG ACAACAGTCTGGAACAGTTGTGCATCAACTACGCCAATGAGAAGCTGCAGCAGCATTTTGTGGCTCACTACCTAAGGGCCCAGCAGGAGGAATACGCAGT TGAGGGCCTGGAGTGGTCATTCATCAACTACCAGGACAACCAGCCCTGTTTGGATCTCATTGAGGGAAGCCCCATCAGCATCTGCTCCCTCATAAATGAG GAATGCCGCCTCAATCGACCCAGCAGCGCAGCCCAGCTCCAGACACGCATTGAGACTGCCCTGGCAGGCAGCCCCTGCCTGGGCCACAATAAGCTCAGCC GGGAGCCCAGCTTCATTGTGGTGCATTATGCGGGGCCTGTGCGGTACCACACAGCAGGCCTGGTGGAGAAGAACAAGGACCCTATCCCACCTGAGCTGAC CAGGCTCCTGCAGCAATCCCAGGACCCCCTGCTCATGGGGCTGTTTCCTACTAACCCCAAAGAGAAGACCCAGGAGGAACCCCCTGGCCAGAGCAGGGCC CCTGTGTTGACCGTGGTGTCCAAGTTCAAGGCCTCACTGGAGCAGCTTCTGCAGGTCCTACACAGCACCACGCCCCACTACATTCGCTGCATCAAGCCCA ACAGCCAGGGCCAGGCGCAGACCTTTCTCCAAGAGGAGGTCCTGAGCCAGCTGGAGGCCTGTGGCCTCGTGGAGACCATCCATATCAGTGCTGCTGGCTT CCCCATCCGGGTCTCTCACCGAAACTTTGTAGAACGATACAAGTTACTAAGAAGGCTTCATCCTTGCACATCCTCTGGCCCCGACAGCCCATATCCTGCC AAAGGGCTCCCTGCCTCTGTCTTCAGAGAGGCACTGGGCATCTAAGGTGGTCAGAGCCCTCAGAATGGTGTCCACACAGCGAGGAAGCCACGCTTGAACC TCTCATCCAGGACATTCTCCACACTCTGCCGGTCCTAACTCAGGCAGCAGCCATAACTGGTGACTCGGCTGAGGCCATGCCAGCCCCCATGCACTGTGGC AGGACCAAGGTGTTCATGACTGACTCTATGCTGGAGCTTCTGGAATGTGGGCGTGCCCGGGTGCTGGAGCAGTGTGCCCGCTGCATCCAGGGTGGCTGGA GGCGACACCGGCACCGAGAGCAGGAGCGGCAGTGGCGGGCCGTCATGCTCATCCAGGCAGCCATTCGTTCCTGGTTAACTCGGAAACACATCCAGAGGCT GCATGCAGCTGCCACAGTCATCAAGCGTGCATGGCAGAAGTGGAGAATCAGAATGGCCTGCCTTGCTGCTAAAGAGCTGGATGGTGTGGAAGAAAAACAC TTCTCTCAAGCTCCCTGTTCCCTGAGCACCTCGCCGCTGCAGACCAGGCTCCTGGAGGCAATAATCCGCCTCTGGCCCCTGGGACTGGTCCTGGCCAATA CGGCTATGGGTGTAGGCAGCTTTCAGAGGAAATTAGTGGTCTGGGCTTGCCTCCAGCTCCCCAGGGGCAGCCCCAGTAGCTACACTGTCCAGACAGCACA AGACCAGGCTGGTGTCACGTCCATCCGAGCGCTGCCTCAGGGATCGATAAAGTTTCACTGCAGAAAGTCTCCACTGCGGTATGCTGACATCTGCCCTGAA CCTTCACCCTACAGCATTACAGGCTTTAATCAGATTCTGCTGGAAAGACACAGGCTGATCCACGTGACCTCTTCTGCCTTCACTGGGCTGGGGTGATCCT TGGTGCCTTTGTTTCCACAAGGCCTTTTCCTGCCCCCTGCCTTGCCAAAGACATTTAATCAGCACACAGCTGCCAGACTATTCCCACAGTGCTCCAAATG CACATGAACAACAGTGACGGCTCCAGCCTTCGACCCAGAGCCCCGTGCCCAGTGCGTCAGTGGGCCTGGGGTTCCAGGCTACATCAAGCACTGATGGTGT CAGGGCTGGTAGTTACCAAATCAGGGTTAAGAAACATCAGGGCCACATTTCACTACCTTCACAGATCAAACTCAGCAGCAGTCATGACTGTCTGTCACTA CACTGGGGATCCCAATTCCACATAAGCACTTTTGGAAGAAAACAGCCAAAGTTGGCCTAAAATTGGCGCTGGAATTTGGGCTGGGAAAAATCTTGTGGTT ATTTCCTTTAAAAAGGAACAAAACTTTAGTATTTAATTAGTTGATTTATTTAATGTAATTTCAAACAATTAAATTATGAATAATGCAATGTA

refseq_MYOHD1.F2 (forward primer)
refseq_MYOHD1.R2 (reverse primer)
Single exon skipping

Frame 0

SFPHCTLLPLLFSLLPVFFPPPDLARPPFQSGR AGA*STAARAVGPCSHPFQKFLAGNRETDWSRSW ENWRKLL*SHLTPARS*CCIVITFAERFHRRWS DLSEIPPELSPLLEPYPSPWSHD*VDSTPCTSC NPEPWLTTLKEDAPAGQWPQSGV*WPSQGVPQRR PAGVPGWGGPAVQTG*PHQGESCDTRDSPEVPA GPVHGRHILHQCWLHPGSLEPLQACSSALLARA NERVPCCASAPETEAPCVHCG*TDLQECQEPD*T SQPVYCCQWREWCWKDMDVSLPNEVLCCGGHLT CILGEPQDCREDRTEDPELQPCHGSFWECVYTE E*QQQSLWEVHPAPAEQGSANDWSRSPDLPPREN SSGLPGFQ*EELPHLLSDLQRSQ*GREAPVAPS *GSCLLLAAQPREELRRGLF*GDQRGHAPFGH* HPYPEQHL*GPSWTAAPWQYPVCCLRG*SPALPA DG*CQVLCQDGSLAAGAPRGRAAGDGAD*NHQG RQTAAGVPEALRPSRV*HP*RLPGQTDLCAVV* LAGISDQQQHLCRHRLVDHFHRPAGCVWI*IIS* QQSGTVVHQLRQ*EAAAAFCGSLPKGPAGGIRS *GPGVVIHQLPGQPALFGSH*GKPHQHLLPHK* GMPPQSTQQRSPAPDTH*DCPGRQPLPGPQ*AQP GAQLHCGALCGACAVPHSRPGGEEQGPYPT*AD QAPAAIPGPPAHGAVSY*PQREDPGGTPWPEQG PCVDRGVQVQGLTGAASAGPTQHHAPLHSLHQAQ QPGPGADLSPRGGPEPAGGLWPRGDHPYQCCWL PHPGLSPKLCRTIQVTKKASSLHILWPRQPISC QRAPCLCLQRGTGHLRWSEPSEWCPHSEEATLEP LIQDILHTLPVLTQAAAITGDSAEAMPAPMHCG RTKVFMTDSMLELLECGRARVLEQCARCIQGGW RRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRL HAAATVIKRAWQKWRIRMACLAAKELDGVEEKH FSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLAN TAMGVGSFQRKLVVWACLQLPRGSPSSYTVQTAQ DQAGVTSIRALPQGSIKFHCRKSPLRYADICPE PSPYSITGFNQILLERHRLIHVTSSAFTGLG*S LVPLFPQGLFLPPALPKTFNQHTAARLFPQCSKC T*TTVTAPAFDPEPRAQCVSGPGVPGYIKH*WC QGW*LPNQG*ETSGPHFTTFTDQTQQQS*LSVT TLGIPIPHKHFWKKTAKVGLKLALEFGLGKILWL FPLKRNKTLVFN*LIYLM*FQTIKL*IMQC

Frame 1

PFLTARSCPSSFLSCPCSSRRLTWPARLSSLAG RGPEARRLGPWDRVHTLSRNSWLVTAKPTGAGA GRTGENCSNLT*LQLGADAAS**HLQSAFTGAGV TCLRFLQN*ALCWNHTPAHGPMTRWIVLLVPPA TQNPG*PL*RRMLQQVNGHNPGSDGQAREYLRE DLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQ ARYMADTFYTNAGCTLVALNPFKPVPQLYSPEL MREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIE PVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSP ASWESHKIAERIEQRILNSNPVMEAFGNACTLR NNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEK TRVACQASSERNFHIFYQICKGASEDERLQWHLP EGAAFSWLPNPERSLEEDCFEVTREAMLHLGID TPTQNNIFKVLAGLLHLGNIQFAASEDEAQPCQ PMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRA GRQQQVFRKPCARAECDTRRDCLAKLIYARLFD WLVSVINSSICADTDSWTTFIGLLDVYGFESFP DNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAV EGLEWSFINYQDNQPCLDLIEGSPISICSLINE ECRLNRPSSAAQLQTRIETALAGSPCLGHNKLS REPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELT RLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRA PVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKP NSQGQAQTFLQEEVLSQLEACGLVETIHISAAGF PIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPA KGLPASVFREALGI*GGQSPQNGVHTARKPRLN LSSRTFSTLCRS*LRQQP*LVTRLRPCQPPCTVA GPRCS*LTLCWSFWNVGVPGCWSSVPAASRVAG GDTGTESRSGSGGPSCSSRQPFVPG*LGNTSRG CMQLPQSSSVHGRSGESEWPALLLKSWMVWKKNT SLKLPVP*APRRCRPGSWRQ*SASGPWDWSWPI RLWV*AAFRGN*WSGLASSSPGAAPVATLSRQH KTRLVSRPSERCLRDR*SFTAESLHCGMLTSALN LHPTALQALIRFCWKDTG*ST*PLLPSLGWGDP WCLCFHKAFSCPLPCQRHLISTQLPDYSHSAPN AHEQQ*RLQPSTQSPVPSASVGLGFQATSSTDGV RAGSYQIRVKKHQGHISLPSQIKLSSSHDCLSL HWGSQFHISTFGRKQPKLA*NWRWNLGWEKSCG YFL*KGTKL*YLIS*FI*CNFKQLNYE*CNV

Frame 2

LSSLHALAPPLFSPARVLPAA*PGPPAFPVWPG GGLKHGGSGRGTVFTPFPEILGW*PRNRLEQEL GELEKTALISLDSS*ELMLHRNNICRALSQALE *LV*DSSRTEPFVGTIPQPMVP*LGG*YSLYLLQ PRTLADHFEGGCSSRSMATIRGLMAKPGSTSEK TCRSSWVGRSCCTNWMTSPG*IL*H*RQS*GAC RPGTWQTHSTPMLAAPW*P*TPSSLFLSSTRPS* *ESTMLRLSPRN*SPMCSLWVNRPTGMSRA*LN QSTSLLLSVERVVLERHGRLAA**SSMLWWPPH LHLGRATRLQRG*NRGS*TPTLSWKLLGMRVH*G ITTAVALGSSSSSS*TGLSK*LEPQSRPTS*RK LEWPARLPVRGTSTSSIRFAKEPVRTRGSSGTF LRELPSPGCPTQRGA*KRIVLR*PERPCSIWALT PLPRTTSLRS*LDCCTLAISSLLPPRMKPSPAS RWMMPSTLSGRQPRCWGSQRTCCWRWCRLEPSG QADSSRCSGSPAPEPSVTPVETAWPN*SMRGCLT GWYQ*STAASVQTPTRGPLS*ACWMCMDLNHFL TTVWNSCASTTPMRSCSSILWLTT*GPSRRNTQ LRAWSGHSSTTRTTSPVWISLREAPSASAPS*MR NAASIDPAAQPSSRHALRLPWQAAPAWATISSA GSPASLWCIMRGLCGTTQQAWWRRTRTLSHLS* PGSCSNPRTPCSWGCFLLTPKRRPRRNPLARAGP LC*PWCPSSRPHWSSFCRSYTAPRPTTFAASSP TARARRRPFSKRRS*ASWRPVASWRPSISVLLA SPSGSLTETL*NDTSY*EGFILAHPLAPTAHILP KGSLPLSSERHWASKVVRALRMVSTQRGSHA*T SHPGHSPHSAGPNSGSSHNW*LG*GHASPHALW QDQGVHD*LYAGASGMWACPGAGAVCPLHPGWLE ATPAPRAGAAVAGRHAHPGSHSFLVNSETHPEA ACSCHSHQACMAEVENQNGLPCC*RAGWCGRKT LLSSSLFPEHLAAADQAPGGNNPPLAPGTGPGQY GYGCRQLSEEISGLGLPPAPQGQPQ*LHCPDST RPGWCHVHPSAASGIDKVSLQKVSTAVC*HLP* TFTLQHYRL*SDSAGKTQADPRDLFCLHWAGVIL GAFVSTRPFPAPCLAKDI*SAHSCQTIPTVLQM HMNNSDGSSLRPRAPCPVRQWAWGSRLHQALMV SGLVVTKSGLRNIRATFHYLHRSNSAAVMTVCHY TGDPNST*ALLEENSQSWPKIGAGIWAGKNLVV ISFKKEQNFSI*LVDLFNVISNN*IMNNAM