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Sequences

Sequence NM_004518

CGCGGAGCGAGGTGGCCGCAGCGTCTCCGCGCGCGGCCCAAGCCCGGCAGGAGTGCGGAACCGCCGCCTCGGCCATGCGGCTCCCGGCCGGGGGGCCTGG
GCTGGGGCCCGCGCCGCCCCCCGCGCTCCGCCCCCGCTGAGCCTGAGCCCGACCCGGGGCGCCTCCCGCCAGGCACCATGGTGCAGAAGTCGCGCAACGG
CGGCGTATACCCCGGCCCGAGCGGGGAGAAGAAGCTGAAGGTGGGCTTCGTGGGGCTGGACCCCGGCGCGCCCGACTCCACCCGGGACGGGGCGCTGCTG
ATCGCCGGCTCCGAGGCCCCCAAGCGCGGCAGCATCCTCAGCAAACCTCGCGCGGGCGGCGCGGGCGCCGGGAAGCCCCCCAAGCGCAACGCCTTCTACC
GCAAGCTGCAGAATTTCCTCTACAACGTGCTGGAGCGGCCGCGCGGCTGGGCGTTCATCTACCACGCCTACGTGTTCCTCCTGGTTTTCTCCTGCCTCGT
GCTGTCTGTGTTTTCCACCATCAAGGAGTATGAGAAGAGCTCGGAGGGGGCCCTCTACATCCTGGAAATCGTGACTATCGTGGTGTTTGGCGTGGAGTAC
TTCGTGCGGATCTGGGCCGCAGGCTGCTGCTGCCGGTACCGTGGCTGGAGGGGGCGGCTCAAGTTTGCCCGGAAACCGTTCTGTGTGATTGACATCATGG
TGCTCATCGCCTCCATTGCGGTGCTGGCCGCCGGCTCCCAGGGCAACGTCTTTGCCACATCTGCGCTCCGGAGCCTGCGCTTCCTGCAGATTCTGCGGAT
GATCCGCATGGACCGGCGGGGAGGCACCTGGAAGCTGCTGGGCTCTGTGGTCTATGCCCACAGCAAGGAGCTGGTCACTGCCTGGTACATCGGCTTCCTT
TGTCTCATCCTGGCCTCGTTCCTGGTGTACTTGGCAGAGAAGGGGGAGAACGACCACTTTGACACCTACGCGGATGCACTCTGGTGGGGCCTGATCACGC
TGACCACCATTGGCTACGGGGACAAGTACCCCCAGACCTGGAACGGCAGGCTCCTTGCGGCAACCTTCACCCTCATCGGTGTCTCCTTCTTCGCGCTGCC
TGCAGGCATCTTGGGGTCTGGGTTTGCCCTGAAGGTTCAGGAGCAGCACAGGCAGAAGCACTTTGAGAAGAGGCGGAACCCGGCAGCAGGCCTGATCCAG
TCGGCCTGGAGATTCTACGCCACCAACCTCTCGCGCACAGACCTGCACTCCACGTGGCAGTACTACGAGCGAACGGTCACCGTGCCCATGTACAGACTTA
TCCCCCCGCTGAACCAGCTGGAGCTGCTGAGGAACCTCAAGAGTAAATCTGGACTCGCTTTCAGGAAGGACCCCCCGCCGGAGCCGTCTCCAAGCCAGAA
GGTCAGTTTGAAAGATCGTGTCTTCTCCAGCCCCCGAGGCGTGGCTGCCAAGGGGAAGGGGTCCCCGCAGGCCCAGACTGTGAGGCGGTCACCCAGCGCC
GACCAGAGCCTCGAGGACAGCCCCAGCAAGGTGCCCAAGAGCTGGAGCTTCGGGGACCGCAGCCGGGCACGCCAGGCTTTCCGCATCAAGGGTGCCGCGT
CACGGCAGAACTCAGAAGAAGCAAGCCTCCCCGGAGAGGACATTGTGGATGACAAGAGCTGCCCCTGCGAGTTTGTGACCGAGGACCTGACCCCGGGCCT
CAAAGTCAGCATCAGAGCCGTGTGTGTCATGCGGTTCCTGGTGTCCAAGCGGAAGTTCAAGGAGAGCCTGCGGCCCTACGACGTGATGGACGTCATCGAG
CAGTACTCAGCCGGCCACCTGGACATGCTGTCCCGAATTAAGAGCCTGCAGTCCAGAGTGGACCAGATCGTGGGGCGGGGCCCAGCGATCACGGACAAGG
ACCGCACCAAGGGCCCGGCCGAGGCGGAGCTGCCCGAGGACCCCAGCATGATGGGACGGCTCGGGAAGGTGGAGAAGCAGGTCTTGTCCATGGAGAAGAA
GCTGGACTTCCTGGTGAATATCTACATGCAGCGGATGGGCATCCCCCCGACAGAGACCGAGGCCTACTTTGGGGCCAAAGAGCCGGAGCCGGCGCCGCCG
TACCACAGCCCGGAAGACAGCCGGGAGCATGTCGACAGGCACGGCTGCATTGTCAAGATCGTGCGCTCCAGCAGCTCCACGGGCCAGAAGAACTTCTCGG
CGCCCCCGGCCGCGCCCCCTGTCCAGTGTCCGCCCTCCACCTCCTGGCAGCCACAGAGCCACCCGCGCCAGGGCCACGGCACCTCCCCCGTGGGGGACCA
CGGCTCCCTGGTGCGCATCCCGCCGCCGCCTGCCCACGAGCGGTCGCTGTCCGCCTACGGCGGGGGCAACCGCGCCAGCATGGAGTTCCTGCGGCAGGAG
GACACCCCGGGCTGCAGGCCCCCCGAGGGGAACCTGCGGGACAGCGACACGTCCATCTCCATCCCGTCCGTGGACCACGAGGAGCTGGAGCGTTCCTTCA
GCGGCTTCAGCATCTCCCAGTCCAAGGAGAACCTGGATGCTCTCAACAGCTGCTACGCGGCCGTGGCGCCTTGTGCCAAAGTCAGGCCCTACATTGCGGA
GGGAGAGTCAGACACCGACTCCGACCTCTGTACCCCGTGCGGGCCCCCGCCACGCTCGGCCACCGGCGAGGGTCCCTTTGGTGACGTGGGCTGGGCCGGG
CCCAGGAAGTGAGGCGGCGCTGGGCCAGTGGACCCGCCCGCGGCCCTCCTCAGCACGGTGCCTCCGAGGTTTTGAGGCGGGAACCCTCTGGGGCCCTTTT
CTTACAGTAACTGAGTGTGGCGGGAAGGGTGGGCCCTGGAGGGGCCCATGTGGGCTGAAGGATGGGGGCTCCTGGCAGTGACCTTTTACAAAAGTTATTT
TCCAACAGGGGCTGGAGGGCTGGGCAGGGCCCTGTGGCTCCAGGAGCAGCGTGCAGGAGCAAGGCTGCCCTGTCCACTCTGCTCAGGGCCGCGGCCGACA
TCAGCCCGGTGTGAGGAGGGGCGGGAGTGATGACGGGGTGTTGCCAGCGTGGCAACAGGCGGGGGGTTGTCTCAGCCGAGCCCAGGGGAGGCACAAAGGG
CAGGCCTGTTCCCTGAGGACCTGCGCAAAGGGCGGGCCTGTTTGGTGAGGACCTGCGGCCTTGGGTC
  • refseq_KCNQ2.F3 (forward primer)
  • refseq_KCNQ2.R3 (reverse primer)
  • Single exon skipping

Frame 0

RGARWPQRLRARPKPGRSAEPPPRPCGSRPGGL
GWGPRRPPRSAPAEPEPDPGRLPPGTMVQKSRNG
GVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALL
IAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFY
RKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLV
LSVFSTIKEYEKSSEGALYILEIVTIVVFGVEY
FVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIM
VLIASIAVLAAGSQGNVFATSALRSLRFLQILRM
IRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFL
CLILASFLVYLAEKGENDHFDTYADALWWGLIT
LTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP
AGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQ
SAWRFYATNLSRTDLHSTWQYYERTVTVPMYRL
IPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQK
VSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSA
DQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAA
SRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGL
KVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIE
QYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDK
DRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKK
LDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPP
YHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFS
APPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDH
GSLVRIPPPPAHERSLSAYGGGNRASMEFLRQE
DTPGCRPPEGNLRDSDTSISIPSVDHEELERSF
SGFSISQSKENLDALNSCYAAVAPCAKVRPYIAE
GESDTDSDLCTPCGPPPRSATGEGPFGDVGWAG
PRK*GGAGPVDPPAALLSTVPPRF*GGNPLGPF
SYSN*VWREGWALEGPMWAEGWGLLAVTFYKSYF
PTGAGGLGRALWLQEQRAGARLPCPLCSGPRPT
SARCEEGRE**RGVASVATGGGLSQPSPGEAQR
AGLFPEDLRKGRACLVRTCGLG

Frame 1

AERGGRSVSARGPSPAGVRNRRLGHAAPGRGAW
AGARAAPRAPPPLSLSPTRGASRQAPWCRSRAT
AAYTPARAGRRS*RWASWGWTPARPTPPGTGRC*
SPAPRPPSAAASSANLARAARAPGSPPSATPST
ASCRISSTTCWSGRAAGRSSTTPTCSSWFSPAS
CCLCFPPSRSMRRARRGPSTSWKS*LSWCLAWST
SCGSGPQAAAAGTVAGGGGSSLPGNRSV*LTSW
CSSPPLRCWPPAPRATSLPHLRSGACASCRFCG
*SAWTGGEAPGSCWALWSMPTARSWSLPGTSASF
VSSWPRSWCTWQRRGRTTTLTPTRMHSGGA*SR
*PPLATGTSTPRPGTAGSLRQPSPSSVSPSSRC
LQASWGLGLP*RFRSSTGRSTLRRGGTRQQA*SS
RPGDSTPPTSRAQTCTPRGSTTSERSPCPCTDL
SPR*TSWSC*GTSRVNLDSLSGRTPRRSRLQAR
RSV*KIVSSPAPEAWLPRGRGPRRPRL*GGHPAP
TRASRTAPARCPRAGASGTAAGHARLSASRVPR
HGRTQKKQASPERTLWMTRAAPASL*PRT*PRA
SKSASEPCVSCGSWCPSGSSRRACGPTT*WTSSS
STQPATWTCCPELRACSPEWTRSWGGAQRSRTR
TAPRARPRRSCPRTPA*WDGSGRWRSRSCPWRR
SWTSW*ISTCSGWASPRQRPRPTLGPKSRSRRRR
TTARKTAGSMSTGTAALSRSCAPAAPRARRTSR
RPRPRPLSSVRPPPPGSHRATRARATAPPPWGT
TAPWCASRRRLPTSGRCPPTAGATAPAWSSCGRR
TPRAAGPPRGTCGTATRPSPSRPWTTRSWSVPS
AASASPSPRRTWMLSTAATRPWRLVPKSGPTLR
RESQTPTPTSVPRAGPRHARPPARVPLVTWAGPG
PGSEAALGQWTRPRPSSARCLRGFEAGTLWGPF
LTVTECGGKGGPWRGPCGLKDGGSWQ*PFTKVI
FQQGLEGWAGPCGSRSSVQEQGCPVHSAQGRGRH
QPGVRRGGSDDGVLPAWQQAGGCLSRAQGRHKG
QACSLRTCAKGGPVW*GPAALG

Frame 2

RSEVAAASPRAAQARQECGTAASAMRLPAGGPG
LGPAPPPALRPR*A*ARPGAPPARHHGAEVAQR
RRIPRPERGEEAEGGLRGAGPRRARLHPGRGAA
DRRLRGPQARQHPQQTSRGRRGRREAPQAQRLLP
QAAEFPLQRAGAAARLGVHLPRLRVPPGFLLPR
AVCVFHHQGV*EELGGGPLHPGNRDYRGVWRGV
LRADLGRRLLLPVPWLEGAAQVCPETVLCD*HHG
AHRLHCGAGRRLPGQRLCHICAPEPALPADSAD
DPHGPAGRHLEAAGLCGLCPQQGAGHCLVHRLP
LSHPGLVPGVLGREGGERPL*HLRGCTLVGPDHA
DHHWLRGQVPPDLERQAPCGNLHPHRCLLLRAA
CRHLGVWVCPEGSGAAQAEAL*EEAEPGSRPDP
VGLEILRHQPLAHRPALHVAVLRANGHRAHVQTY
PPAEPAGAAEEPQE*IWTRFQEGPPAGAVSKPE
GQFERSCLLQPPRRGCQGEGVPAGPDCEAVTQR
RPEPRGQPQQGAQELELRGPQPGTPGFPHQGCRV
TAELRRSKPPRRGHCG*QELPLRVCDRGPDPGP
QSQHQSRVCHAVPGVQAEVQGEPAALRRDGRHR
AVLSRPPGHAVPN*EPAVQSGPDRGAGPSDHGQG
PHQGPGRGGAARGPQHDGTAREGGEAGLVHGEE
AGLPGEYLHAADGHPPDRDRGLLWGQRAGAGAA
VPQPGRQPGACRQARLHCQDRALQQLHGPEELLG
APGRAPCPVSALHLLAATEPPAPGPRHLPRGGP
RLPGAHPAAACPRAVAVRLRRGQPRQHGVPAAG
GHPGLQAPRGEPAGQRHVHLHPVRGPRGAGAFLQ
RLQHLPVQGEPGCSQQLLRGRGALCQSQALHCG
GRVRHRLRPLYPVRAPATLGHRRGSLW*RGLGR
AQEVRRRWASGPARGPPQHGASEVLRREPSGALF
LQ*LSVAGRVGPGGAHVG*RMGAPGSDLLQKLF
SNRGWRAGQGPVAPGAACRSKAALSTLLRAAAD
ISPV*GGAGVMTGCCQRGNRRGVVSAEPRGGTKG
RPVP*GPAQRAGLFGEDLRPWV

Sequence NM_172106

CGCGGAGCGAGGTGGCCGCAGCGTCTCCGCGCGCGGCCCAAGCCCGGCAGGAGTGCGGAACCGCCGCCTCGGCCATGCGGCTCCCGGCCGGGGGGCCTGG
GCTGGGGCCCGCGCCGCCCCCCGCGCTCCGCCCCCGCTGAGCCTGAGCCCGACCCGGGGCGCCTCCCGCCAGGCACCATGGTGCAGAAGTCGCGCAACGG
CGGCGTATACCCCGGCCCGAGCGGGGAGAAGAAGCTGAAGGTGGGCTTCGTGGGGCTGGACCCCGGCGCGCCCGACTCCACCCGGGACGGGGCGCTGCTG
ATCGCCGGCTCCGAGGCCCCCAAGCGCGGCAGCATCCTCAGCAAACCTCGCGCGGGCGGCGCGGGCGCCGGGAAGCCCCCCAAGCGCAACGCCTTCTACC
GCAAGCTGCAGAATTTCCTCTACAACGTGCTGGAGCGGCCGCGCGGCTGGGCGTTCATCTACCACGCCTACGTGTTCCTCCTGGTTTTCTCCTGCCTCGT
GCTGTCTGTGTTTTCCACCATCAAGGAGTATGAGAAGAGCTCGGAGGGGGCCCTCTACATCCTGGAAATCGTGACTATCGTGGTGTTTGGCGTGGAGTAC
TTCGTGCGGATCTGGGCCGCAGGCTGCTGCTGCCGGTACCGTGGCTGGAGGGGGCGGCTCAAGTTTGCCCGGAAACCGTTCTGTGTGATTGACATCATGG
TGCTCATCGCCTCCATTGCGGTGCTGGCCGCCGGCTCCCAGGGCAACGTCTTTGCCACATCTGCGCTCCGGAGCCTGCGCTTCCTGCAGATTCTGCGGAT
GATCCGCATGGACCGGCGGGGAGGCACCTGGAAGCTGCTGGGCTCTGTGGTCTATGCCCACAGCAAGGAGCTGGTCACTGCCTGGTACATCGGCTTCCTT
TGTCTCATCCTGGCCTCGTTCCTGGTGTACTTGGCAGAGAAGGGGGAGAACGACCACTTTGACACCTACGCGGATGCACTCTGGTGGGGCCTGATCACGC
TGACCACCATTGGCTACGGGGACAAGTACCCCCAGACCTGGAACGGCAGGCTCCTTGCGGCAACCTTCACCCTCATCGGTGTCTCCTTCTTCGCGCTGCC
TGCAGGCATCTTGGGGTCTGGGTTTGCCCTGAAGGTTCAGGAGCAGCACAGGCAGAAGCACTTTGAGAAGAGGCGGAACCCGGCAGCAGGCCTGATCCAG
TCGGCCTGGAGATTCTACGCCACCAACCTCTCGCGCACAGACCTGCACTCCACGTGGCAGTACTACGAGCGAACGGTCACCGTGCCCATGTACAGTTCGC
AAACTCAAACCTACGGGGCCTCCAGACTTATCCCCCCGCTGAACCAGCTGGAGCTGCTGAGGAACCTCAAGAGTAAATCTGGACTCGCTTTCAGGAAGGA
CCCCCCGCCGGAGCCGTCTCCAAGCCAGAAGGTCAGTTTGAAAGATCGTGTCTTCTCCAGCCCCCGAGGCGTGGCTGCCAAGGGGAAGGGGTCCCCGCAG
GCCCAGACTGTGAGGCGGTCACCCAGCGCCGACCAGAGCCTCGAGGACAGCCCCAGCAAGGTGCCCAAGAGCTGGAGCTTCGGGGACCGCAGCCGGGCAC
GCCAGGCTTTCCGCATCAAGGGTGCCGCGTCACGGCAGAACTCAGAAGAAGCAAGCCTCCCCGGAGAGGACATTGTGGATGACAAGAGCTGCCCCTGCGA
GTTTGTGACCGAGGACCTGACCCCGGGCCTCAAAGTCAGCATCAGAGCCGTGTGTGTCATGCGGTTCCTGGTGTCCAAGCGGAAGTTCAAGGAGAGCCTG
CGGCCCTACGACGTGATGGACGTCATCGAGCAGTACTCAGCCGGCCACCTGGACATGCTGTCCCGAATTAAGAGCCTGCAGTCCAGAGTGGACCAGATCG
TGGGGCGGGGCCCAGCGATCACGGACAAGGACCGCACCAAGGGCCCGGCCGAGGCGGAGCTGCCCGAGGACCCCAGCATGATGGGACGGCTCGGGAAGGT
GGAGAAGCAGGTCTTGTCCATGGAGAAGAAGCTGGACTTCCTGGTGAATATCTACATGCAGCGGATGGGCATCCCCCCGACAGAGACCGAGGCCTACTTT
GGGGCCAAAGAGCCGGAGCCGGCGCCGCCGTACCACAGCCCGGAAGACAGCCGGGAGCATGTCGACAGGCACGGCTGCATTGTCAAGATCGTGCGCTCCA
GCAGCTCCACGGGCCAGAAGAACTTCTCGGCGCCCCCGGCCGCGCCCCCTGTCCAGTGTCCGCCCTCCACCTCCTGGCAGCCACAGAGCCACCCGCGCCA
GGGCCACGGCACCTCCCCCGTGGGGGACCACGGCTCCCTGGTGCGCATCCCGCCGCCGCCTGCCCACGAGCGGTCGCTGTCCGCCTACGGCGGGGGCAAC
CGCGCCAGCATGGAGTTCCTGCGGCAGGAGGACACCCCGGGCTGCAGGCCCCCCGAGGGGAACCTGCGGGACAGCGACACGTCCATCTCCATCCCGTCCG
TGGACCACGAGGAGCTGGAGCGTTCCTTCAGCGGCTTCAGCATCTCCCAGTCCAAGGAGAACCTGGATGCTCTCAACAGCTGCTACGCGGCCGTGGCGCC
TTGTGCCAAAGTCAGGCCCTACATTGCGGAGGGAGAGTCAGACACCGACTCCGACCTCTGTACCCCGTGCGGGCCCCCGCCACGCTCGGCCACCGGCGAG
GGTCCCTTTGGTGACGTGGGCTGGGCCGGGCCCAGGAAGTGAGGCGGCGCTGGGCCAGTGGACCCGCCCGCGGCCCTCCTCAGCACGGTGCCTCCGAGGT
TTTGAGGCGGGAACCCTCTGGGGCCCTTTTCTTACAGTAACTGAGTGTGGCGGGAAGGGTGGGCCCTGGAGGGGCCCATGTGGGCTGAAGGATGGGGGCT
CCTGGCAGTGACCTTTTACAAAAGTTATTTTCCAACAGGGGCTGGAGGGCTGGGCAGGGCCCTGTGGCTCCAGGAGCAGCGTGCAGGAGCAAGGCTGCCC
TGTCCACTCTGCTCAGGGCCGCGGCCGACATCAGCCCGGTGTGAGGAGGGGCGGGAGTGATGACGGGGTGTTGCCAGCGTGGCAACAGGCGGGGGGTTGT
CTCAGCCGAGCCCAGGGGAGGCACAAAGGGCAGGCCTGTTCCCTGAGGACCTGCGCAAAGGGCGGGCCTGTTTGGTGAGGACCTGCGGCCTTGGGTC
  • refseq_KCNQ2.F3 (forward primer)
  • refseq_KCNQ2.R3 (reverse primer)
  • Single exon skipping

Frame 0

RGARWPQRLRARPKPGRSAEPPPRPCGSRPGGL
GWGPRRPPRSAPAEPEPDPGRLPPGTMVQKSRNG
GVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALL
IAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFY
RKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLV
LSVFSTIKEYEKSSEGALYILEIVTIVVFGVEY
FVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIM
VLIASIAVLAAGSQGNVFATSALRSLRFLQILRM
IRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFL
CLILASFLVYLAEKGENDHFDTYADALWWGLIT
LTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP
AGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQ
SAWRFYATNLSRTDLHSTWQYYERTVTVPMYSS
QTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKD
PPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQ
AQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRA
RQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCE
FVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESL
RPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQI
VGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKV
EKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYF
GAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRS
SSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQ
GHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGN
RASMEFLRQEDTPGCRPPEGNLRDSDTSISIPS
VDHEELERSFSGFSISQSKENLDALNSCYAAVAP
CAKVRPYIAEGESDTDSDLCTPCGPPPRSATGE
GPFGDVGWAGPRK*GGAGPVDPPAALLSTVPPR
F*GGNPLGPFSYSN*VWREGWALEGPMWAEGWGL
LAVTFYKSYFPTGAGGLGRALWLQEQRAGARLP
CPLCSGPRPTSARCEEGRE**RGVASVATGGGL
SQPSPGEAQRAGLFPEDLRKGRACLVRTCGLG

Frame 1

AERGGRSVSARGPSPAGVRNRRLGHAAPGRGAW
AGARAAPRAPPPLSLSPTRGASRQAPWCRSRAT
AAYTPARAGRRS*RWASWGWTPARPTPPGTGRC*
SPAPRPPSAAASSANLARAARAPGSPPSATPST
ASCRISSTTCWSGRAAGRSSTTPTCSSWFSPAS
CCLCFPPSRSMRRARRGPSTSWKS*LSWCLAWST
SCGSGPQAAAAGTVAGGGGSSLPGNRSV*LTSW
CSSPPLRCWPPAPRATSLPHLRSGACASCRFCG
*SAWTGGEAPGSCWALWSMPTARSWSLPGTSASF
VSSWPRSWCTWQRRGRTTTLTPTRMHSGGA*SR
*PPLATGTSTPRPGTAGSLRQPSPSSVSPSSRC
LQASWGLGLP*RFRSSTGRSTLRRGGTRQQA*SS
RPGDSTPPTSRAQTCTPRGSTTSERSPCPCTVR
KLKPTGPPDLSPR*TSWSC*GTSRVNLDSLSGR
TPRRSRLQARRSV*KIVSSPAPEAWLPRGRGPRR
PRL*GGHPAPTRASRTAPARCPRAGASGTAAGH
ARLSASRVPRHGRTQKKQASPERTLWMTRAAPA
SL*PRT*PRASKSASEPCVSCGSWCPSGSSRRAC
GPTT*WTSSSSTQPATWTCCPELRACSPEWTRS
WGGAQRSRTRTAPRARPRRSCPRTPA*WDGSGR
WRSRSCPWRRSWTSW*ISTCSGWASPRQRPRPTL
GPKSRSRRRRTTARKTAGSMSTGTAALSRSCAP
AAPRARRTSRRPRPRPLSSVRPPPPGSHRATRA
RATAPPPWGTTAPWCASRRRLPTSGRCPPTAGAT
APAWSSCGRRTPRAAGPPRGTCGTATRPSPSRP
WTTRSWSVPSAASASPSPRRTWMLSTAATRPWR
LVPKSGPTLRRESQTPTPTSVPRAGPRHARPPAR
VPLVTWAGPGPGSEAALGQWTRPRPSSARCLRG
FEAGTLWGPFLTVTECGGKGGPWRGPCGLKDGG
SWQ*PFTKVIFQQGLEGWAGPCGSRSSVQEQGCP
VHSAQGRGRHQPGVRRGGSDDGVLPAWQQAGGC
LSRAQGRHKGQACSLRTCAKGGPVW*GPAALG

Frame 2

RSEVAAASPRAAQARQECGTAASAMRLPAGGPG
LGPAPPPALRPR*A*ARPGAPPARHHGAEVAQR
RRIPRPERGEEAEGGLRGAGPRRARLHPGRGAA
DRRLRGPQARQHPQQTSRGRRGRREAPQAQRLLP
QAAEFPLQRAGAAARLGVHLPRLRVPPGFLLPR
AVCVFHHQGV*EELGGGPLHPGNRDYRGVWRGV
LRADLGRRLLLPVPWLEGAAQVCPETVLCD*HHG
AHRLHCGAGRRLPGQRLCHICAPEPALPADSAD
DPHGPAGRHLEAAGLCGLCPQQGAGHCLVHRLP
LSHPGLVPGVLGREGGERPL*HLRGCTLVGPDHA
DHHWLRGQVPPDLERQAPCGNLHPHRCLLLRAA
CRHLGVWVCPEGSGAAQAEAL*EEAEPGSRPDP
VGLEILRHQPLAHRPALHVAVLRANGHRAHVQFA
NSNLRGLQTYPPAEPAGAAEEPQE*IWTRFQEG
PPAGAVSKPEGQFERSCLLQPPRRGCQGEGVPA
GPDCEAVTQRRPEPRGQPQQGAQELELRGPQPGT
PGFPHQGCRVTAELRRSKPPRRGHCG*QELPLR
VCDRGPDPGPQSQHQSRVCHAVPGVQAEVQGEP
AALRRDGRHRAVLSRPPGHAVPN*EPAVQSGPDR
GAGPSDHGQGPHQGPGRGGAARGPQHDGTAREG
GEAGLVHGEEAGLPGEYLHAADGHPPDRDRGLL
WGQRAGAGAAVPQPGRQPGACRQARLHCQDRALQ
QLHGPEELLGAPGRAPCPVSALHLLAATEPPAP
GPRHLPRGGPRLPGAHPAAACPRAVAVRLRRGQ
PRQHGVPAAGGHPGLQAPRGEPAGQRHVHLHPVR
GPRGAGAFLQRLQHLPVQGEPGCSQQLLRGRGA
LCQSQALHCGGRVRHRLRPLYPVRAPATLGHRR
GSLW*RGLGRAQEVRRRWASGPARGPPQHGASEV
LRREPSGALFLQ*LSVAGRVGPGGAHVG*RMGA
PGSDLLQKLFSNRGWRAGQGPVAPGAACRSKAA
LSTLLRAAADISPV*GGAGVMTGCCQRGNRRGVV
SAEPRGGTKGRPVP*GPAQRAGLFGEDLRPWV

Sequence NM_172107

CGCGGAGCGAGGTGGCCGCAGCGTCTCCGCGCGCGGCCCAAGCCCGGCAGGAGTGCGGAACCGCCGCCTCGGCCATGCGGCTCCCGGCCGGGGGGCCTGG
GCTGGGGCCCGCGCCGCCCCCCGCGCTCCGCCCCCGCTGAGCCTGAGCCCGACCCGGGGCGCCTCCCGCCAGGCACCATGGTGCAGAAGTCGCGCAACGG
CGGCGTATACCCCGGCCCGAGCGGGGAGAAGAAGCTGAAGGTGGGCTTCGTGGGGCTGGACCCCGGCGCGCCCGACTCCACCCGGGACGGGGCGCTGCTG
ATCGCCGGCTCCGAGGCCCCCAAGCGCGGCAGCATCCTCAGCAAACCTCGCGCGGGCGGCGCGGGCGCCGGGAAGCCCCCCAAGCGCAACGCCTTCTACC
GCAAGCTGCAGAATTTCCTCTACAACGTGCTGGAGCGGCCGCGCGGCTGGGCGTTCATCTACCACGCCTACGTGTTCCTCCTGGTTTTCTCCTGCCTCGT
GCTGTCTGTGTTTTCCACCATCAAGGAGTATGAGAAGAGCTCGGAGGGGGCCCTCTACATCCTGGAAATCGTGACTATCGTGGTGTTTGGCGTGGAGTAC
TTCGTGCGGATCTGGGCCGCAGGCTGCTGCTGCCGGTACCGTGGCTGGAGGGGGCGGCTCAAGTTTGCCCGGAAACCGTTCTGTGTGATTGACATCATGG
TGCTCATCGCCTCCATTGCGGTGCTGGCCGCCGGCTCCCAGGGCAACGTCTTTGCCACATCTGCGCTCCGGAGCCTGCGCTTCCTGCAGATTCTGCGGAT
GATCCGCATGGACCGGCGGGGAGGCACCTGGAAGCTGCTGGGCTCTGTGGTCTATGCCCACAGCAAGGAGCTGGTCACTGCCTGGTACATCGGCTTCCTT
TGTCTCATCCTGGCCTCGTTCCTGGTGTACTTGGCAGAGAAGGGGGAGAACGACCACTTTGACACCTACGCGGATGCACTCTGGTGGGGCCTGATCACGC
TGACCACCATTGGCTACGGGGACAAGTACCCCCAGACCTGGAACGGCAGGCTCCTTGCGGCAACCTTCACCCTCATCGGTGTCTCCTTCTTCGCGCTGCC
TGCAGGCATCTTGGGGTCTGGGTTTGCCCTGAAGGTTCAGGAGCAGCACAGGCAGAAGCACTTTGAGAAGAGGCGGAACCCGGCAGCAGGCCTGATCCAG
TCGGCCTGGAGATTCTACGCCACCAACCTCTCGCGCACAGACCTGCACTCCACGTGGCAGTACTACGAGCGAACGGTCACCGTGCCCATGTACAGTTCGC
AAACTCAAACCTACGGGGCCTCCAGACTTATCCCCCCGCTGAACCAGCTGGAGCTGCTGAGGAACCTCAAGAGTAAATCTGGACTCGCTTTCAGGAAGGA
CCCCCCGCCGGAGCCGTCTCCAAGTAAAGGCAGCCCGTGCAGAGGGCCCCTGTGTGGATGCTGCCCCGGACGCTCTAGCCAGAAGGTCAGTTTGAAAGAT
CGTGTCTTCTCCAGCCCCCGAGGCGTGGCTGCCAAGGGGAAGGGGTCCCCGCAGGCCCAGACTGTGAGGCGGTCACCCAGCGCCGACCAGAGCCTCGAGG
ACAGCCCCAGCAAGGTGCCCAAGAGCTGGAGCTTCGGGGACCGCAGCCGGGCACGCCAGGCTTTCCGCATCAAGGGTGCCGCGTCACGGCAGAACTCAGA
AGAAGCAAGCCTCCCCGGAGAGGACATTGTGGATGACAAGAGCTGCCCCTGCGAGTTTGTGACCGAGGACCTGACCCCGGGCCTCAAAGTCAGCATCAGA
GCCGTGTGTGTCATGCGGTTCCTGGTGTCCAAGCGGAAGTTCAAGGAGAGCCTGCGGCCCTACGACGTGATGGACGTCATCGAGCAGTACTCAGCCGGCC
ACCTGGACATGCTGTCCCGAATTAAGAGCCTGCAGTCCAGAGTGGACCAGATCGTGGGGCGGGGCCCAGCGATCACGGACAAGGACCGCACCAAGGGCCC
GGCCGAGGCGGAGCTGCCCGAGGACCCCAGCATGATGGGACGGCTCGGGAAGGTGGAGAAGCAGGTCTTGTCCATGGAGAAGAAGCTGGACTTCCTGGTG
AATATCTACATGCAGCGGATGGGCATCCCCCCGACAGAGACCGAGGCCTACTTTGGGGCCAAAGAGCCGGAGCCGGCGCCGCCGTACCACAGCCCGGAAG
ACAGCCGGGAGCATGTCGACAGGCACGGCTGCATTGTCAAGATCGTGCGCTCCAGCAGCTCCACGGGCCAGAAGAACTTCTCGGCGCCCCCGGCCGCGCC
CCCTGTCCAGTGTCCGCCCTCCACCTCCTGGCAGCCACAGAGCCACCCGCGCCAGGGCCACGGCACCTCCCCCGTGGGGGACCACGGCTCCCTGGTGCGC
ATCCCGCCGCCGCCTGCCCACGAGCGGTCGCTGTCCGCCTACGGCGGGGGCAACCGCGCCAGCATGGAGTTCCTGCGGCAGGAGGACACCCCGGGCTGCA
GGCCCCCCGAGGGGAACCTGCGGGACAGCGACACGTCCATCTCCATCCCGTCCGTGGACCACGAGGAGCTGGAGCGTTCCTTCAGCGGCTTCAGCATCTC
CCAGTCCAAGGAGAACCTGGATGCTCTCAACAGCTGCTACGCGGCCGTGGCGCCTTGTGCCAAAGTCAGGCCCTACATTGCGGAGGGAGAGTCAGACACC
GACTCCGACCTCTGTACCCCGTGCGGGCCCCCGCCACGCTCGGCCACCGGCGAGGGTCCCTTTGGTGACGTGGGCTGGGCCGGGCCCAGGAAGTGAGGCG
GCGCTGGGCCAGTGGACCCGCCCGCGGCCCTCCTCAGCACGGTGCCTCCGAGGTTTTGAGGCGGGAACCCTCTGGGGCCCTTTTCTTACAGTAACTGAGT
GTGGCGGGAAGGGTGGGCCCTGGAGGGGCCCATGTGGGCTGAAGGATGGGGGCTCCTGGCAGTGACCTTTTACAAAAGTTATTTTCCAACAGGGGCTGGA
GGGCTGGGCAGGGCCCTGTGGCTCCAGGAGCAGCGTGCAGGAGCAAGGCTGCCCTGTCCACTCTGCTCAGGGCCGCGGCCGACATCAGCCCGGTGTGAGG
AGGGGCGGGAGTGATGACGGGGTGTTGCCAGCGTGGCAACAGGCGGGGGGTTGTCTCAGCCGAGCCCAGGGGAGGCACAAAGGGCAGGCCTGTTCCCTGA
GGACCTGCGCAAAGGGCGGGCCTGTTTGGTGAGGACCTGCGGCCTTGGGTC
  • refseq_KCNQ2.F3 (forward primer)
  • refseq_KCNQ2.R3 (reverse primer)
  • Single exon skipping

Frame 0

RGARWPQRLRARPKPGRSAEPPPRPCGSRPGGL
GWGPRRPPRSAPAEPEPDPGRLPPGTMVQKSRNG
GVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALL
IAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFY
RKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLV
LSVFSTIKEYEKSSEGALYILEIVTIVVFGVEY
FVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIM
VLIASIAVLAAGSQGNVFATSALRSLRFLQILRM
IRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFL
CLILASFLVYLAEKGENDHFDTYADALWWGLIT
LTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP
AGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQ
SAWRFYATNLSRTDLHSTWQYYERTVTVPMYSS
QTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKD
PPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKD
RVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLE
DSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSE
EASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIR
AVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAG
HLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGP
AEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLV
NIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPE
DSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAP
PVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVR
IPPPPAHERSLSAYGGGNRASMEFLRQEDTPGC
RPPEGNLRDSDTSISIPSVDHEELERSFSGFSIS
QSKENLDALNSCYAAVAPCAKVRPYIAEGESDT
DSDLCTPCGPPPRSATGEGPFGDVGWAGPRK*G
GAGPVDPPAALLSTVPPRF*GGNPLGPFSYSN*V
WREGWALEGPMWAEGWGLLAVTFYKSYFPTGAG
GLGRALWLQEQRAGARLPCPLCSGPRPTSARCE
EGRE**RGVASVATGGGLSQPSPGEAQRAGLFPE
DLRKGRACLVRTCGLG

Frame 1

AERGGRSVSARGPSPAGVRNRRLGHAAPGRGAW
AGARAAPRAPPPLSLSPTRGASRQAPWCRSRAT
AAYTPARAGRRS*RWASWGWTPARPTPPGTGRC*
SPAPRPPSAAASSANLARAARAPGSPPSATPST
ASCRISSTTCWSGRAAGRSSTTPTCSSWFSPAS
CCLCFPPSRSMRRARRGPSTSWKS*LSWCLAWST
SCGSGPQAAAAGTVAGGGGSSLPGNRSV*LTSW
CSSPPLRCWPPAPRATSLPHLRSGACASCRFCG
*SAWTGGEAPGSCWALWSMPTARSWSLPGTSASF
VSSWPRSWCTWQRRGRTTTLTPTRMHSGGA*SR
*PPLATGTSTPRPGTAGSLRQPSPSSVSPSSRC
LQASWGLGLP*RFRSSTGRSTLRRGGTRQQA*SS
RPGDSTPPTSRAQTCTPRGSTTSERSPCPCTVR
KLKPTGPPDLSPR*TSWSC*GTSRVNLDSLSGR
TPRRSRLQVKAARAEGPCVDAAPDALARRSV*KI
VSSPAPEAWLPRGRGPRRPRL*GGHPAPTRASR
TAPARCPRAGASGTAAGHARLSASRVPRHGRTQ
KKQASPERTLWMTRAAPASL*PRT*PRASKSASE
PCVSCGSWCPSGSSRRACGPTT*WTSSSSTQPA
TWTCCPELRACSPEWTRSWGGAQRSRTRTAPRA
RPRRSCPRTPA*WDGSGRWRSRSCPWRRSWTSW*
ISTCSGWASPRQRPRPTLGPKSRSRRRRTTARK
TAGSMSTGTAALSRSCAPAAPRARRTSRRPRPR
PLSSVRPPPPGSHRATRARATAPPPWGTTAPWCA
SRRRLPTSGRCPPTAGATAPAWSSCGRRTPRAA
GPPRGTCGTATRPSPSRPWTTRSWSVPSAASAS
PSPRRTWMLSTAATRPWRLVPKSGPTLRRESQTP
TPTSVPRAGPRHARPPARVPLVTWAGPGPGSEA
ALGQWTRPRPSSARCLRGFEAGTLWGPFLTVTE
CGGKGGPWRGPCGLKDGGSWQ*PFTKVIFQQGLE
GWAGPCGSRSSVQEQGCPVHSAQGRGRHQPGVR
RGGSDDGVLPAWQQAGGCLSRAQGRHKGQACSL
RTCAKGGPVW*GPAALG

Frame 2

RSEVAAASPRAAQARQECGTAASAMRLPAGGPG
LGPAPPPALRPR*A*ARPGAPPARHHGAEVAQR
RRIPRPERGEEAEGGLRGAGPRRARLHPGRGAA
DRRLRGPQARQHPQQTSRGRRGRREAPQAQRLLP
QAAEFPLQRAGAAARLGVHLPRLRVPPGFLLPR
AVCVFHHQGV*EELGGGPLHPGNRDYRGVWRGV
LRADLGRRLLLPVPWLEGAAQVCPETVLCD*HHG
AHRLHCGAGRRLPGQRLCHICAPEPALPADSAD
DPHGPAGRHLEAAGLCGLCPQQGAGHCLVHRLP
LSHPGLVPGVLGREGGERPL*HLRGCTLVGPDHA
DHHWLRGQVPPDLERQAPCGNLHPHRCLLLRAA
CRHLGVWVCPEGSGAAQAEAL*EEAEPGSRPDP
VGLEILRHQPLAHRPALHVAVLRANGHRAHVQFA
NSNLRGLQTYPPAEPAGAAEEPQE*IWTRFQEG
PPAGAVSK*RQPVQRAPVWMLPRTL*PEGQFER
SCLLQPPRRGCQGEGVPAGPDCEAVTQRRPEPRG
QPQQGAQELELRGPQPGTPGFPHQGCRVTAELR
RSKPPRRGHCG*QELPLRVCDRGPDPGPQSQHQ
SRVCHAVPGVQAEVQGEPAALRRDGRHRAVLSRP
PGHAVPN*EPAVQSGPDRGAGPSDHGQGPHQGP
GRGGAARGPQHDGTAREGGEAGLVHGEEAGLPG
EYLHAADGHPPDRDRGLLWGQRAGAGAAVPQPGR
QPGACRQARLHCQDRALQQLHGPEELLGAPGRA
PCPVSALHLLAATEPPAPGPRHLPRGGPRLPGA
HPAAACPRAVAVRLRRGQPRQHGVPAAGGHPGLQ
APRGEPAGQRHVHLHPVRGPRGAGAFLQRLQHL
PVQGEPGCSQQLLRGRGALCQSQALHCGGRVRH
RLRPLYPVRAPATLGHRRGSLW*RGLGRAQEVRR
RWASGPARGPPQHGASEVLRREPSGALFLQ*LS
VAGRVGPGGAHVG*RMGAPGSDLLQKLFSNRGW
RAGQGPVAPGAACRSKAALSTLLRAAADISPV*G
GAGVMTGCCQRGNRRGVVSAEPRGGTKGRPVP*
GPAQRAGLFGEDLRPWV

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