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Sequences

Sequence NM_207297

GTTGGTACTAAGAAGTGCCTTTCCTGACGTCTCTGCTGCTTGGAACCGCTTCTAGAGCAGTCTCTGCTTTTGCCTTGCTTGCTGCCAGCTAGACTGTGAC
GACAGCACATCCACCCTCCACCTCTAGCCCAGACACCCCCATTTCTACTTATAATCAAGAGAAAAGCTCTAAGTATCTGGCATTGCCCTAGGCTGCTTTA
GTGTTAAAAGAAAAGTTTGCTGAAAAAGTAAGATATCTTCTGCCAGGAAATCAAGGAGGAAAAAAAAAATCATTTTCTCGATTTTGCTCTAAACTGCTGC
ATCTGTCTATGCCAAACTAATCAATACCGATTGCACCACCAAACTCCATTGCAAATTCAGCTGTGAGGAGATTCCCTTTCAGACAACTTTGCTGAAAGCA
GCTTGGAAATTCGGTGTCGAAGGGTCTGCCACGTTTTCATGCTTGCATTTTGGGCTCCAAATTGGCACTGGGAAGGGGTTACTGAGAGCACAAGGCTGAT
ACCAGGCCCTACTTTTAAACGTTCATCTACTTACAATCCTAGTATTTCTCTAAAAACCAAAACCTCTTTGAATTAACAGTTTCATGCTGTGAATTTCTAG
TGGGAGATCTTTTCCTTGATATTGACGACACAATTTTCCATGTACTTTTAAAGCAGGGAGTGGGGAAAAGTATTTTGAGGGGACATTTTCATCATCAGTT
CAGCTTTTTTTTTTTGGTTGTTGCTCTTTTTTGGGGGGGTTGGGTTTGTTGGTTTCACTGAAACATTTAACTACCTGTAAAATCTAAACATGGCTGTTAG
TGTCACACCAATTCGGGACACAAAATGGCTAACACTGGAAGTATGTAGAGAGTTCCAGAGGGGGACTTGCTCACGGCCAGACACGGAATGTAAATTTGCA
CATCCTTCGAAAAGCTGCCAAGTTGAAAATGGACGAGTAATCGCCTGCTTTGATTCATTGAAAGGCCGTTGCTCCAGGGAGAACTGCAAATATCTTCATC
CACCCCCACATTTAAAAACGCAGTTGGAGATAAATGGACGCAATAACTTGATTCAGCAGAAGAACATGGCCATGTTGGCCCAGCAAATGCAACTAGCCAA
TGCCATGATGCCTGGTGCCCCATTACAACCCGTGCCAATGTTTTCAGTTGCACCAAGCTTAGCCACCAATGCATCAGCAGCCGCCTTTAATCCCTATCTG
GGACCTGTTTCTCCAAGCCTGGTCCCGGCAGAGATCTTGCCGACTGCACCAATGTTGGTTACAGGGAATCCGGGTGTCCCTGTACCTGCAGCTGCTGCAG
CTGCTGCACAGAAATTAATGCGAACAGACAGACTTGAGGTATGTCGAGAGTACCAACGTGGCAATTGCAACCGAGGAGAAAATGATTGTCGGTTTGCTCA
TCCTGCTGACAGCACAATGATTGACACCAATGACAACACAGTCACTGTGTGTATGGATTACATCAAAGGGAGATGCTCTCGGGAAAAGTGCAAATACTTT
CATCCCCCTGCACATTTGCAAGCCAAGATCAAGGCTGCCCAATACCAGGTCAACCAGGCTGCAGCTGCACAGGCTGCAGCCACCGCAGCTGCCATGGGAA
TTCCTCAAGCTGTACTTCCCCCATTACCAAAGAGGCCTGCTCTTGAAAAAACCAACGGTGCCACCGCAGTCTTTAACACTGGTATTTTCCAATACCAACA
GGCTCTAGCCAACATGCAGTTACAACAGCATACAGCATTTCTCCCACCAGGCTCAATATTGTGCATGACACCCGCTACAAGTGTTGATACCCATAATATC
TGCCGAACATCTGACTAGCCACAAGTATGTTACCCAGATGTAGAATTTTCATCACTAAACAATCATGCTAAAGAGGAAAGGACAGTGTGCTTGGTTAGAG
TAAAGGACGAGGTCATTAGCCATATTGTATATATCGTCAAGCAACACACACAAAAGTTCCTCAGCCACAAGACATCCACATATTGCATGTTAACCAGAAG
AAAAGACAACATTTTCCGGAAATCCACTGCACACTGTTGCCTATACACTTTGTACATTTAATTGATATTTGTGCTGAGGTGATATTCCTGTCTAAAAGAA
CAACATTGTCTTTCTTTTCTAGCACAGAGTTATGCATTCAAAGATGCATACCTAGTTAGTTTCCTATATATTCATGCCATCTTGAAAAGACAGACTATGG
TGTAACCATGATTCTATTATGTATTGGTACGTCTGTAGACCAAGATATAATTTTTTAAAAATAAGTTTATTTCTTTCAAGGTTTACAAATAACAAAGGTG
CACCTTGTATTTAAAATTGCCATTATAGATGAGAGCGTGCATGCACAGTCATTTTTGTTTAAGAGTAATATTTTTAATGTAATAGATTGTAAGACGTGGT
GAGGGAGGGATCTGACAGAGATGAATGTGCCAAGCAAAACCACAACTGTGTATATTTTAAAGCACATCATGGCTTTAAGTACCATGTTGTTAAGGATTCT
CATGAAGTGCCATAGACTGTACATCAAATTAGAGTATTATTTCTTCAGTGTTATTGTTTTCAGAGCCACATTTTGTTGCATATTTGCTAGTACTAATCAG
TCAAAGGGCACCATTCTTTTTTTTTTTTTTTGAAACCAAAGCTGTCTCAGAAATGGCCAATTTAACTTTACAGTAACAATAGACAGCACAACACAAACTC
TCTCAATACAGATAAACTCACACATACTGGAGATATATATATAATAGATATATATAAAATTATTTTAATGCATTGTAGTGTAATATTTATGCATACTATA
CTGTATAACATGTTATTCAAAAGGGATTGCCATTTCTGAGACACAGTAACAAAAAAATGAGGAAATTATTTTGCTTCTATTTATAGCCTCTGTCAAAAGT
CAAAAGACTATAAATGCTTTGCAAAAATGGTTTCACGTTTGCTTAAATGCTTCATCACAGTCACATTCAAAATAGTGACTCTAAACAAAGAAGAAAGCAG
CACTGTCATCAGATGCATGATAAACCAAAATATGAAAATGGGAAATGTTTAATTAACCTAGTAATTGGGTGGGTTAAGTACATGGGTGAATTTTATATGT
GATTTTTGTTTTGTTTTGTTTTGTTCAGATTAACTGCTTATAGCCTTAGAAAGCCTTTTACAAAATTAAAAAAAAAATAGATGTGCATTCAGTTTTTAAG
AATGGAATCATCCAAAGGAATTCCTTTTTTTGAGGTTTGGATGTTGCAGCTAGTAAAGGATATTTTTGCTCTGTTCAGCAGTTCTAAAAATTGCTGAAGT
AGGGGCCAGGTCACTGGTAGTTATAGTATGGAATGGGAGAAGTGAAAGTTCAGTTATAGAACTTTCCATACTTCCAAGTTTACTGCAAGTTTTTATGCTT
GAGAGAGATGCTTTCTAATATAAGACTGATGTGTTGATTTTACTGATTGTACTGTACATCTATTAAAGCCTTAGATTATTACATTACGGGTTGGAACCCA
TACCAATGTAATTTCAATCGTGTTAAGAAAGTAATGGTGACTTCACATGTTATTGTAGTTAGTTACATTATAGAATATTACTTATTTTTCTTGTTAAAAT
GTAGTTTTTCATTTCCTACATTTATTAGATTTTCATTTTCTATTAACAATTGAATACCATTTCAGTTTATAGACTTGTTTTATTAGATTTTACCAATGAA
TTTTTCAAAATACAAAAAAAAGTAGTTTTTCCTTCATAACATACTCAGTTTTGAATTACATGTAGTGTCACATGAATATTCGTATTGTTAACTAAATGAT
TTATATTTTACTGATTTAATATTACAGTGTAAGAATGTCAGTCATTGTTAGTTCTTGTCTAGTTTTCATTAAAAGAACAAAGATCTTTTATATGGATATC
TTATAAATATATAATCATTGCTAAGTAAGAAGTTAAGTTGTTGCTATCGCAACAATCCTGGCAGACAATTGAGTAATATTTTGATGATTTATTTTGTTTG
TAATTAGTTATTATAAGAAGATCTAGATCCTAGATATTAGAATAAAATTTATTTTCTACTGTATCCATTTCAAATGTTAAAATATTGTTTAATATTTTTG
AAATCCCTGAGTATCAGGCCTTGTTATAAATAAGCTGCATAATCAATAAATAGAACAAGGGACTTTTTGTTGATAATCCAAATACTCAAAGTTTACGTAA
TGAAAATTATAGCGTGTGTGCAAACTCTTGAGGGTTGATTATGCTGCAATTTAGCATGTTGGAACGTCTAGGGAGAAGGTTGACTTTTTGCACTTCTGTA
TATAGTCAAAAGAGAGAAACCTGTATAATAGTAAGATCTTATTTTGAATAAAAACGTCTATAATTACAAGGAGTTTTGTTAAGGCTAATACAATGACAGA
CTGAGCAAAATTGCTTGCAAAAGTGGCACAGAGTTAGCACTCCATACCCCTTCAAACATGTTGCTTTGCTTTCTTGTGGACAGCTTGTAGTTTGCCAGGA
TTTTTTCAGCTGGAAAGATACGCCATCCTTTCAAACCCTCATGACTGACAAAAACTCCATGGGGCCAAATCTGCCTGAAGATCATTACCAAAAATAGCAG
GTACTTCTACCATTAAGGTGAAATCATGGATCAGATATTCCTTACATTTTTCAAAACTACTGCATGTTTAAAACTTCAACAAAAAAAGAGAGAAAGAACT
ATACTAAGAACATATATTATTCAGATCAGTTTCTGCCAATTTCAGTGGTTTATTGTTCACAAAAAAATCTTCAAAACAAGTATTGACTTTCACAAAATTT
AAATCATAAACAGGCAAACCAAACAGCACACTGTAGCTATAGTTGTTATGTGATTGTTTTTTAATTGCTGTAGGATCCTGTTCTTTCAGCAGGTGAAAAA
TAAAACGCAGTTCAAATTTCATGGTTTTAATTTTCAACTCAGAAGCACTCAAAAATGCAAAATGTGATAATGGGCACTTGTTTAAAAGAATTAGTGTATC
CAGCCTTCACTCCAGCTGGTTAAAAATGTTGCACTTATCAGCAACCCTACCACTTTCATCTGCTGAAAGGACAAATGTGCTTGGTTTTACTATTATGTAA
TCACAACTTACTTTCTGCTTGTAGTTGCTTAAAATTATGTATTTTGTCTTGGGCTGCAATTTGTTTTATGCTTATTTTATTATTACTGCAGTAGTTGACT
TTGCTGTATGGAAAAATAAAGTGAAATTGCCCTAATAAAACTTCTCTTTCTTAAGTA
  • refseq_MBNL1.F7 (forward primer)
  • refseq_MBNL1.R7 (reverse primer)
  • Single exon skipping

Frame 0

VGTKKCLS*RLCCLEPLLEQSLLLPCLLPARL*
RQHIHPPPLAQTPPFLLIIKRKALSIWHCPRLL*
C*KKSLLKK*DIFCQEIKEEKKNHFLDFALNCC
ICLCQTNQYRLHHQTPLQIQL*GDSLSDNFAES
SLEIRCRRVCHVFMLAFWAPNWHWEGVTESTRLI
PGPTFKRSSTYNPSISLKTKTSLN*QFHAVNF*
WEIFSLILTTQFSMYF*SREWGKVF*GDIFIIS
SAFFFWLLLFFGGVGFVGFTETFNYL*NLNMAVS
VTPIRDTKWLTLEVCREFQRGTCSRPDTECKFA
HPSKSCQVENGRVIACFDSLKGRCSRENCKYLH
PPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLAN
AMMPGAPLQPVPMFSVAPSLATNASAAAFNPYL
GPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAA
AAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAH
PADSTMIDTNDNTVTVCMDYIKGRCSREKCKYF
HPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMG
IPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQ
ALANMQLQQHTAFLPPGSILCMTPATSVDTHNI
CRTSD*PQVCYPDVEFSSLNNHAKEERTVCLVR
VKDEVISHIVYIVKQHTQKFLSHKTSTYCMLTRR
KDNIFRKSTAHCCLYTLYI*LIFVLR*YSCLKE
QHCLSFLAQSYAFKDAYLVSFLYIHAILKRQTM
V*P*FYYVLVRL*TKI*FFKNKFISFKVYK*QRC
TLYLKLPL*MRACMHSHFCLRVIFLM**IVRRG
EGGI*QR*MCQAKPQLCIF*STSWL*VPCC*GF
S*SAIDCTSN*SIISSVLLFSEPHFVAYLLVLIS
QRAPFFFFFFETKAVSEMANLTLQ*Q*TAQHKL
SQYR*THTYWRYIYNRYI*NYFNAL*CNIYAYY
TV*HVIQKGLPFLRHSNKKMRKLFCFYL*PLSKV
KRL*MLCKNGFTFA*MLHHSHIQNSDSKQRRKQ
HCHQMHDKPKYENGKCLINLVIGWVKYMGEFYM
*FLFCFVLFRLTAYSLRKPFTKLKKK*MCIQFLR
MESSKGIPFFEVWMLQLVKDIFALFSSSKNC*S
RGQVTGSYSMEWEK*KFSYRTFHTSKFTASFYA
*ERCFLI*D*CVDFTDCTVHLLKP*IITLRVGTH
TNVISIVLRK*W*LHMLL*LVTL*NITYFSC*N
VVFHFLHLLDFHFLLTIEYHFSL*TCFIRFYQ*
IFQNTKKSSFSFITYSVLNYM*CHMNIRIVN*MI
YILLI*YYSVRMSVIVSSCLVFIKRTKIFYMDI
L*IYNHC*VRS*VVAIATILADN*VIF**FILF
VISYYKKI*ILDIRIKFIFYCIHFKC*NIV*YF*
NP*VSGLVINKLHNQ*IEQGTFC**SKYSKFT*
*KL*RVCKLLRVDYAAI*HVGTSREKVDFLHFC
I*SKERNLYNSKILF*IKTSIITRSFVKANTMTD
*AKLLAKVAQS*HSIPLQTCCFAFLWTACSLPG
FFQLERYAILSNPHD*QKLHGAKSA*RSLPKIA
GTSTIKVKSWIRYSLHFSKLLHV*NFNKKREKEL
Y*EHILFRSVSANFSGLLFTKKSSKQVLTFTKF
KS*TGKPNSTL*L*LLCDCFLIAVGSCSFSR*K
IKRSSNFMVLIFNSEALKNAKCDNGHLFKRISVS
SLHSSWLKMLHLSATLPLSSAERTNVLGFTIM*
SQLTFCL*LLKIMYFVLGCNLFYAYFIITAVVD
FAVWKNKVKLP**NFSFLS

Frame 1

LVLRSAFPDVSAAWNRF*SSLCFCLACCQLDCD
DSTSTLHL*PRHPHFYL*SREKL*VSGIALGCF
SVKRKVC*KSKISSARKSRRKKKIIFSILL*TAA
SVYAKLINTDCTTKLHCKFSCEEIPFQTTLLKA
AWKFGVEGSATFSCLHFGLQIGTGKGLLRAQG*
YQALLLNVHLLTILVFL*KPKPL*INSFML*ISS
GRSFP*Y*RHNFPCTFKAGSGEKYFEGTFSSSV
QLFFFGCCSFLGGLGLLVSLKHLTTCKI*TWLL
VSHQFGTQNG*HWKYVESSRGGLAHGQTRNVNLH
ILRKAAKLKMDE*SPALIH*KAVAPGRTANIFI
HPHI*KRSWR*MDAIT*FSRRTWPCWPSKCN*P
MP*CLVPHYNPCQCFQLHQA*PPMHQQPPLIPIW
DLFLQAWSRQRSCRLHQCWLQGIRVSLYLQLLQ
LLHRN*CEQTDLRYVESTNVAIATEEKMIVGLL
ILLTAQ*LTPMTTQSLCVWITSKGDALGKSANTF
IPLHICKPRSRLPNTRSTRLQLHRLQPPQLPWE
FLKLYFPHYQRGLLLKKPTVPPQSLTLVFSNTN
RL*PTCSYNSIQHFSHQAQYCA*HPLQVLIPIIS
AEHLTSHKYVTQM*NFHH*TIMLKRKGQCAWLE
*RTRSLAILYISSSNTHKSSSATRHPHIAC*PE
EKTTFSGNPLHTVAYTLCTFN*YLC*GDIPV*KN
NIVFLF*HRVMHSKMHT*LVSYIFMPS*KDRLW
CNHDSIMYWYVCRPRYNFLKISLFLSRFTNNKG
APCI*NCHYR*ERACTVIFV*E*YF*CNRL*DVV
REGSDRDECAKQNHNCVYFKAHHGFKYHVVKDS
HEVP*TVHQIRVLFLQCYCFQSHILLHIC*Y*S
VKGHHSFFFFLKPKLSQKWPI*LYSNNRQHNTNS
LNTDKLTHTGDIYIIDIYKIILMHCSVIFMHTI
LYNMLFKRDCHF*DTVTKK*GNYFASIYSLCQK
SKDYKCFAKMVSRLLKCFITVTFKIVTLNKEESS
TVIRCMINQNMKMGNV*LT**LGGLSTWVNFIC
DFCFVLFCSD*LLIALESLLQN*KKNRCAFSF*
EWNHPKEFLFLRFGCCS**RIFLLCSAVLKIAEV
GARSLVVIVWNGRSESSVIELSILPSLLQVFML
ERDAF*YKTDVLILLIVLYIY*SLRLLHYGLEP
IPM*FQSC*ESNGDFTCYCS*LHYRILLIFLVKM
*FFISYIY*IFIFY*QLNTISVYRLVLLDFTNE
FFKIQKKVVFPS*HTQF*ITCSVT*IFVLLTK*
FIFY*FNITV*ECQSLLVLV*FSLKEQRSFIWIS
YKYIIIAK*EVKLLLSQQSWQTIE*YFDDLFCL
*LVIIRRSRS*ILE*NLFSTVSISNVKILFNIF
EIPEYQALL*ISCIINK*NKGLFVDNPNTQSLRN
ENYSVCANS*GLIMLQFSMLERLGRRLTFCTSV
YSQKRETCIIVRSYFE*KRL*LQGVLLRLIQ*Q
TEQNCLQKWHRVSTPYPFKHVALLSCGQLVVCQD
FFSWKDTPSFQTLMTDKNSMGPNLPEDHYQK*Q
VLLPLR*NHGSDIPYIFQNYCMFKTSTKKERKN
YTKNIYYSDQFLPISVVYCSQKNLQNKY*LSQNL
NHKQANQTAHCSYSCYVIVF*LL*DPVLSAGEK
*NAVQISWF*FSTQKHSKMQNVIMGTCLKELVY
PAFTPAG*KCCTYQQPYHFHLLKGQMCLVLLLCN
HNLLSACSCLKLCILSWAAICFMLILLLLQ*LT
LLYGKIK*NCPNKTSLS*V

Frame 2

WY*EVPFLTSLLLGTASRAVSAFALLAAS*TVT
TAHPPSTSSPDTPISTYNQEKSSKYLALP*AAL
VLKEKFAEKVRYLLPGNQGGKKKSFSRFCSKLL
HLSMPN*SIPIAPPNSIANSAVRRFPFRQLC*KQ
LGNSVSKGLPRFHACILGSKLALGRGY*EHKAD
TRPYF*TFIYLQS*YFSKNQNLFELTVSCCEFL
VGDLFLDIDDTIFHVLLKQGVGKSILRGHFHHQF
SFFFLVVALFWGGWVCWFH*NI*LPVKSKHGC*
CHTNSGHKMANTGSM*RVPEGDLLTARHGM*IC
TSFEKLPS*KWTSNRLL*FIERPLLQGELQISSS
TPTFKNAVGDKWTQ*LDSAEEHGHVGPANATSQ
CHDAWCPITTRANVFSCTKLSHQCISSRL*SLS
GTCFSKPGPGRDLADCTNVGYRESGCPCTCSCCS
CCTEINANRQT*GMSRVPTWQLQPRRK*LSVCS
SC*QHND*HQ*QHSHCVYGLHQREMLSGKVQIL
SSPCTFASQDQGCPIPGQPGCSCTGCSHRSCHGN
SSSCTSPITKEACS*KNQRCHRSL*HWYFPIPT
GSSQHAVTTAYSISPTRLNIVHDTRYKC*YP*Y
LPNI*LATSMLPRCRIFITKQSC*RGKDSVLG*S
KGRGH*PYCIYRQATHTKVPQPQDIHILHVNQK
KRQHFPEIHCTLLPIHFVHLIDICAEVIFLSKR
TTLSFFSSTELCIQRCIPS*FPIYSCHLEKTDYG
VTMILLCIGTSVDQDIIF*K*VYFFQGLQITKV
HLVFKIAIIDESVHAQSFLFKSNIFNVIDCKTW
*GRDLTEMNVPSKTTTVYILKHIMALSTMLLRIL
MKCHRLYIKLEYYFFSVIVFRATFCCIFASTNQ
SKGTILFFFF*NQSCLRNGQFNFTVTIDSTTQT
LSIQINSHILEIYI**IYIKLF*CIVV*YLCILY
CITCYSKGIAISETQ*QKNEEIILLLFIASVKS
QKTINALQKWFHVCLNASSQSHSK**L*TKKKA
ALSSDA**TKI*KWEMFN*PSNWVG*VHG*ILYV
IFVLFCFVQINCL*P*KAFYKIKKKIDVHSVFK
NGIIQRNSFF*GLDVAASKGYFCSVQQF*KLLK
*GPGHW*L*YGMGEVKVQL*NFPYFQVYCKFLCL
REMLSNIRLMC*FY*LYCTSIKALDYYITGWNP
YQCNFNRVKKVMVTSHVIVVSYIIEYYLFFLLK
CSFSFPTFIRFSFSINN*IPFQFIDLFY*ILPMN
FSKYKKK*FFLHNILSFELHVVSHEYSYC*LND
LYFTDLILQCKNVSHC*FLSSFH*KNKDLLYGY
LINI*SLLSKKLSCCYRNNPGRQLSNILMIYFVC
N*LL*EDLDPRY*NKIYFLLYPFQMLKYCLIFL
KSLSIRPCYK*AA*SINRTRDFLLIIQILKVYV
MKIIACVQTLEG*LCCNLACWNV*GEG*LFALLY
IVKREKPV***DLILNKNVYNYKEFC*G*YNDR
LSKIACKSGTELALHTPSNMLLCFLVDSL*FAR
IFSAGKIRHPFKPS*LTKTPWGQICLKIITKNSR
YFYH*GEIMDQIFLTFFKTTACLKLQQKKRERT
ILRTYIIQISFCQFQWFIVHKKIFKTSIDFHKI
*IINRQTKQHTVAIVVM*LFFNCCRILFFQQVKN
KTQFKFHGFNFQLRSTQKCKM**WALV*KN*CI
QPSLQLVKNVALISNPTTFIC*KDKCAWFYYYV
ITTYFLLVVA*NYVFCLGLQFVLCLFYYYCSS*L
CCMEK*SEIALIKLLFLK

Sequence NM_207295

GTTGGTACTAAGAAGTGCCTTTCCTGACGTCTCTGCTGCTTGGAACCGCTTCTAGAGCAGTCTCTGCTTTTGCCTTGCTTGCTGCCAGCTAGACTGTGAC
GACAGCACATCCACCCTCCACCTCTAGCCCAGACACCCCCATTTCTACTTATAATCAAGAGAAAAGCTCTAAGTATCTGGCATTGCCCTAGGCTGCTTTA
GTGTTAAAAGAAAAGTTTGCTGAAAAAGTAAGATATCTTCTGCCAGGAAATCAAGGAGGAAAAAAAAAATCATTTTCTCGATTTTGCTCTAAACTGCTGC
ATCTGTCTATGCCAAACTAATCAATACCGATTGCACCACCAAACTCCATTGCAAATTCAGCTGTGAGGAGATTCCCTTTCAGACAACTTTGCTGAAAGCA
GCTTGGAAATTCGGTGTCGAAGGGTCTGCCACGTTTTCATGCTTGCATTTTGGGCTCCAAATTGGCACTGGGAAGGGGTTACTGAGAGCACAAGGCTGAT
ACCAGGCCCTACTTTTAAACGTTCATCTACTTACAATCCTAGTATTTCTCTAAAAACCAAAACCTCTTTGAATTAACAGTTTCATGCTGTGAATTTCTAG
TGGGAGATCTTTTCCTTGATATTGACGACACAATTTTCCATGTACTTTTAAAGCAGGGAGTGGGGAAAAGTATTTTGAGGGGACATTTTCATCATCAGTT
CAGCTTTTTTTTTTTGGTTGTTGCTCTTTTTTGGGGGGGTTGGGTTTGTTGGTTTCACTGAAACATTTAACTACCTGTAAAATCTAAACATGGCTGTTAG
TGTCACACCAATTCGGGACACAAAATGGCTAACACTGGAAGTATGTAGAGAGTTCCAGAGGGGGACTTGCTCACGGCCAGACACGGAATGTAAATTTGCA
CATCCTTCGAAAAGCTGCCAAGTTGAAAATGGACGAGTAATCGCCTGCTTTGATTCATTGAAAGGCCGTTGCTCCAGGGAGAACTGCAAATATCTTCATC
CACCCCCACATTTAAAAACGCAGTTGGAGATAAATGGACGCAATAACTTGATTCAGCAGAAGAACATGGCCATGTTGGCCCAGCAAATGCAACTAGCCAA
TGCCATGATGCCTGGTGCCCCATTACAACCCGTGGTATGTCGAGAGTACCAACGTGGCAATTGCAACCGAGGAGAAAATGATTGTCGGTTTGCTCATCCT
GCTGACAGCACAATGATTGACACCAATGACAACACAGTCACTGTGTGTATGGATTACATCAAAGGGAGATGCTCTCGGGAAAAGTGCAAATACTTTCATC
CCCCTGCACATTTGCAAGCCAAGATCAAGGCTGCCCAATACCAGGTCAACCAGGCTGCAGCTGCACAGGCTGCAGCCACCGCAGCTGCCATGGGAATTCC
TCAAGCTGTACTTCCCCCATTACCAAAGAGGCCTGCTCTTGAAAAAACCAACGGTGCCACCGCAGTCTTTAACACTGGTATTTTCCAATACCAACAGGCT
CTAGCCAACATGCAGTTACAACAGCATACAGCATTTCTCCCACCAGGCTCAATATTGTGCATGACACCCGCTACAAGTGTTGTTCCCATGGTGCACGGTG
CTACGCCAGCCACTGTGTCCGCAGCAACAACATCTGCCACAAGTGTTCCCTTCGCTGCAACAGCCACAGCCAACCAGATACCCATAATATCTGCCGAACA
TCTGACTAGCCACAAGTATGTTACCCAGATGTAGAATTTTCATCACTAAACAATCATGCTAAAGAGGAAAGGACAGTGTGCTTGGTTAGAGTAAAGGACG
AGGTCATTAGCCATATTGTATATATCGTCAAGCAACACACACAAAAGTTCCTCAGCCACAAGACATCCACATATTGCATGTTAACCAGAAGAAAAGACAA
CATTTTCCGGAAATCCACTGCACACTGTTGCCTATACACTTTGTACATTTAATTGATATTTGTGCTGAGGTGATATTCCTGTCTAAAAGAACAACATTGT
CTTTCTTTTCTAGCACAGAGTTATGCATTCAAAGATGCATACCTAGTTAGTTTCCTATATATTCATGCCATCTTGAAAAGACAGACTATGGTGTAACCAT
GATTCTATTATGTATTGGTACGTCTGTAGACCAAGATATAATTTTTTAAAAATAAGTTTATTTCTTTCAAGGTTTACAAATAACAAAGGTGCACCTTGTA
TTTAAAATTGCCATTATAGATGAGAGCGTGCATGCACAGTCATTTTTGTTTAAGAGTAATATTTTTAATGTAATAGATTGTAAGACGTGGTGAGGGAGGG
ATCTGACAGAGATGAATGTGCCAAGCAAAACCACAACTGTGTATATTTTAAAGCACATCATGGCTTTAAGTACCATGTTGTTAAGGATTCTCATGAAGTG
CCATAGACTGTACATCAAATTAGAGTATTATTTCTTCAGTGTTATTGTTTTCAGAGCCACATTTTGTTGCATATTTGCTAGTACTAATCAGTCAAAGGGC
ACCATTCTTTTTTTTTTTTTTTGAAACCAAAGCTGTCTCAGAAATGGCCAATTTAACTTTACAGTAACAATAGACAGCACAACACAAACTCTCTCAATAC
AGATAAACTCACACATACTGGAGATATATATATAATAGATATATATAAAATTATTTTAATGCATTGTAGTGTAATATTTATGCATACTATACTGTATAAC
ATGTTATTCAAAAGGGATTGCCATTTCTGAGACACAGTAACAAAAAAATGAGGAAATTATTTTGCTTCTATTTATAGCCTCTGTCAAAAGTCAAAAGACT
ATAAATGCTTTGCAAAAATGGTTTCACGTTTGCTTAAATGCTTCATCACAGTCACATTCAAAATAGTGACTCTAAACAAAGAAGAAAGCAGCACTGTCAT
CAGATGCATGATAAACCAAAATATGAAAATGGGAAATGTTTAATTAACCTAGTAATTGGGTGGGTTAAGTACATGGGTGAATTTTATATGTGATTTTTGT
TTTGTTTTGTTTTGTTCAGATTAACTGCTTATAGCCTTAGAAAGCCTTTTACAAAATTAAAAAAAAAATAGATGTGCATTCAGTTTTTAAGAATGGAATC
ATCCAAAGGAATTCCTTTTTTTGAGGTTTGGATGTTGCAGCTAGTAAAGGATATTTTTGCTCTGTTCAGCAGTTCTAAAAATTGCTGAAGTAGGGGCCAG
GTCACTGGTAGTTATAGTATGGAATGGGAGAAGTGAAAGTTCAGTTATAGAACTTTCCATACTTCCAAGTTTACTGCAAGTTTTTATGCTTGAGAGAGAT
GCTTTCTAATATAAGACTGATGTGTTGATTTTACTGATTGTACTGTACATCTATTAAAGCCTTAGATTATTACATTACGGGTTGGAACCCATACCAATGT
AATTTCAATCGTGTTAAGAAAGTAATGGTGACTTCACATGTTATTGTAGTTAGTTACATTATAGAATATTACTTATTTTTCTTGTTAAAATGTAGTTTTT
CATTTCCTACATTTATTAGATTTTCATTTTCTATTAACAATTGAATACCATTTCAGTTTATAGACTTGTTTTATTAGATTTTACCAATGAATTTTTCAAA
ATACAAAAAAAAGTAGTTTTTCCTTCATAACATACTCAGTTTTGAATTACATGTAGTGTCACATGAATATTCGTATTGTTAACTAAATGATTTATATTTT
ACTGATTTAATATTACAGTGTAAGAATGTCAGTCATTGTTAGTTCTTGTCTAGTTTTCATTAAAAGAACAAAGATCTTTTATATGGATATCTTATAAATA
TATAATCATTGCTAAGTAAGAAGTTAAGTTGTTGCTATCGCAACAATCCTGGCAGACAATTGAGTAATATTTTGATGATTTATTTTGTTTGTAATTAGTT
ATTATAAGAAGATCTAGATCCTAGATATTAGAATAAAATTTATTTTCTACTGTATCCATTTCAAATGTTAAAATATTGTTTAATATTTTTGAAATCCCTG
AGTATCAGGCCTTGTTATAAATAAGCTGCATAATCAATAAATAGAACAAGGGACTTTTTGTTGATAATCCAAATACTCAAAGTTTACGTAATGAAAATTA
TAGCGTGTGTGCAAACTCTTGAGGGTTGATTATGCTGCAATTTAGCATGTTGGAACGTCTAGGGAGAAGGTTGACTTTTTGCACTTCTGTATATAGTCAA
AAGAGAGAAACCTGTATAATAGTAAGATCTTATTTTGAATAAAAACGTCTATAATTACAAGGAGTTTTGTTAAGGCTAATACAATGACAGACTGAGCAAA
ATTGCTTGCAAAAGTGGCACAGAGTTAGCACTCCATACCCCTTCAAACATGTTGCTTTGCTTTCTTGTGGACAGCTTGTAGTTTGCCAGGATTTTTTCAG
CTGGAAAGATACGCCATCCTTTCAAACCCTCATGACTGACAAAAACTCCATGGGGCCAAATCTGCCTGAAGATCATTACCAAAAATAGCAGGTACTTCTA
CCATTAAGGTGAAATCATGGATCAGATATTCCTTACATTTTTCAAAACTACTGCATGTTTAAAACTTCAACAAAAAAAGAGAGAAAGAACTATACTAAGA
ACATATATTATTCAGATCAGTTTCTGCCAATTTCAGTGGTTTATTGTTCACAAAAAAATCTTCAAAACAAGTATTGACTTTCACAAAATTTAAATCATAA
ACAGGCAAACCAAACAGCACACTGTAGCTATAGTTGTTATGTGATTGTTTTTTAATTGCTGTAGGATCCTGTTCTTTCAGCAGGTGAAAAATAAAACGCA
GTTCAAATTTCATGGTTTTAATTTTCAACTCAGAAGCACTCAAAAATGCAAAATGTGATAATGGGCACTTGTTTAAAAGAATTAGTGTATCCAGCCTTCA
CTCCAGCTGGTTAAAAATGTTGCACTTATCAGCAACCCTACCACTTTCATCTGCTGAAAGGACAAATGTGCTTGGTTTTACTATTATGTAATCACAACTT
ACTTTCTGCTTGTAGTTGCTTAAAATTATGTATTTTGTCTTGGGCTGCAATTTGTTTTATGCTTATTTTATTATTACTGCAGTAGTTGACTTTGCTGTAT
GGAAAAATAAAGTGAAATTGCCCTAATAAAACTTCTCTTTCTTAAGTA
  • refseq_MBNL1.F7 (forward primer)
  • refseq_MBNL1.R7 (reverse primer)
  • Single exon skipping

Frame 0

VGTKKCLS*RLCCLEPLLEQSLLLPCLLPARL*
RQHIHPPPLAQTPPFLLIIKRKALSIWHCPRLL*
C*KKSLLKK*DIFCQEIKEEKKNHFLDFALNCC
ICLCQTNQYRLHHQTPLQIQL*GDSLSDNFAES
SLEIRCRRVCHVFMLAFWAPNWHWEGVTESTRLI
PGPTFKRSSTYNPSISLKTKTSLN*QFHAVNF*
WEIFSLILTTQFSMYF*SREWGKVF*GDIFIIS
SAFFFWLLLFFGGVGFVGFTETFNYL*NLNMAVS
VTPIRDTKWLTLEVCREFQRGTCSRPDTECKFA
HPSKSCQVENGRVIACFDSLKGRCSRENCKYLH
PPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLAN
AMMPGAPLQPVVCREYQRGNCNRGENDCRFAHP
ADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFH
PPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIP
QAVLPPLPKRPALEKTNGATAVFNTGIFQYQQA
LANMQLQQHTAFLPPGSILCMTPATSVVPMVHG
ATPATVSAATTSATSVPFAATATANQIPIISAEH
LTSHKYVTQM*NFHH*TIMLKRKGQCAWLE*RT
RSLAILYISSSNTHKSSSATRHPHIAC*PEEKT
TFSGNPLHTVAYTLCTFN*YLC*GDIPV*KNNIV
FLF*HRVMHSKMHT*LVSYIFMPS*KDRLWCNH
DSIMYWYVCRPRYNFLKISLFLSRFTNNKGAPC
I*NCHYR*ERACTVIFV*E*YF*CNRL*DVVREG
SDRDECAKQNHNCVYFKAHHGFKYHVVKDSHEV
P*TVHQIRVLFLQCYCFQSHILLHIC*Y*SVKG
HHSFFFFLKPKLSQKWPI*LYSNNRQHNTNSLNT
DKLTHTGDIYIIDIYKIILMHCSVIFMHTILYN
MLFKRDCHF*DTVTKK*GNYFASIYSLCQKSKD
YKCFAKMVSRLLKCFITVTFKIVTLNKEESSTVI
RCMINQNMKMGNV*LT**LGGLSTWVNFICDFC
FVLFCSD*LLIALESLLQN*KKNRCAFSF*EWN
HPKEFLFLRFGCCS**RIFLLCSAVLKIAEVGAR
SLVVIVWNGRSESSVIELSILPSLLQVFMLERD
AF*YKTDVLILLIVLYIY*SLRLLHYGLEPIPM
*FQSC*ESNGDFTCYCS*LHYRILLIFLVKM*FF
ISYIY*IFIFY*QLNTISVYRLVLLDFTNEFFK
IQKKVVFPS*HTQF*ITCSVT*IFVLLTK*FIF
Y*FNITV*ECQSLLVLV*FSLKEQRSFIWISYKY
IIIAK*EVKLLLSQQSWQTIE*YFDDLFCL*LV
IIRRSRS*ILE*NLFSTVSISNVKILFNIFEIP
EYQALL*ISCIINK*NKGLFVDNPNTQSLRNENY
SVCANS*GLIMLQFSMLERLGRRLTFCTSVYSQ
KRETCIIVRSYFE*KRL*LQGVLLRLIQ*QTEQ
NCLQKWHRVSTPYPFKHVALLSCGQLVVCQDFFS
WKDTPSFQTLMTDKNSMGPNLPEDHYQK*QVLL
PLR*NHGSDIPYIFQNYCMFKTSTKKERKNYTK
NIYYSDQFLPISVVYCSQKNLQNKY*LSQNLNHK
QANQTAHCSYSCYVIVF*LL*DPVLSAGEK*NA
VQISWF*FSTQKHSKMQNVIMGTCLKELVYPAF
TPAG*KCCTYQQPYHFHLLKGQMCLVLLLCNHNL
LSACSCLKLCILSWAAICFMLILLLLQ*LTLLY
GKIK*NCPNKTSLS*V

Frame 1

LVLRSAFPDVSAAWNRF*SSLCFCLACCQLDCD
DSTSTLHL*PRHPHFYL*SREKL*VSGIALGCF
SVKRKVC*KSKISSARKSRRKKKIIFSILL*TAA
SVYAKLINTDCTTKLHCKFSCEEIPFQTTLLKA
AWKFGVEGSATFSCLHFGLQIGTGKGLLRAQG*
YQALLLNVHLLTILVFL*KPKPL*INSFML*ISS
GRSFP*Y*RHNFPCTFKAGSGEKYFEGTFSSSV
QLFFFGCCSFLGGLGLLVSLKHLTTCKI*TWLL
VSHQFGTQNG*HWKYVESSRGGLAHGQTRNVNLH
ILRKAAKLKMDE*SPALIH*KAVAPGRTANIFI
HPHI*KRSWR*MDAIT*FSRRTWPCWPSKCN*P
MP*CLVPHYNPWYVESTNVAIATEEKMIVGLLIL
LTAQ*LTPMTTQSLCVWITSKGDALGKSANTFI
PLHICKPRSRLPNTRSTRLQLHRLQPPQLPWEF
LKLYFPHYQRGLLLKKPTVPPQSLTLVFSNTNRL
*PTCSYNSIQHFSHQAQYCA*HPLQVLFPWCTV
LRQPLCPQQQHLPQVFPSLQQPQPTRYP*YLPN
I*LATSMLPRCRIFITKQSC*RGKDSVLG*SKGR
GH*PYCIYRQATHTKVPQPQDIHILHVNQKKRQ
HFPEIHCTLLPIHFVHLIDICAEVIFLSKRTTL
SFFSSTELCIQRCIPS*FPIYSCHLEKTDYGVTM
ILLCIGTSVDQDIIF*K*VYFFQGLQITKVHLV
FKIAIIDESVHAQSFLFKSNIFNVIDCKTW*GR
DLTEMNVPSKTTTVYILKHIMALSTMLLRILMKC
HRLYIKLEYYFFSVIVFRATFCCIFASTNQSKG
TILFFFF*NQSCLRNGQFNFTVTIDSTTQTLSI
QINSHILEIYI**IYIKLF*CIVV*YLCILYCIT
CYSKGIAISETQ*QKNEEIILLLFIASVKSQKT
INALQKWFHVCLNASSQSHSK**L*TKKKAALS
SDA**TKI*KWEMFN*PSNWVG*VHG*ILYVIFV
LFCFVQINCL*P*KAFYKIKKKIDVHSVFKNGI
IQRNSFF*GLDVAASKGYFCSVQQF*KLLK*GP
GHW*L*YGMGEVKVQL*NFPYFQVYCKFLCLREM
LSNIRLMC*FY*LYCTSIKALDYYITGWNPYQC
NFNRVKKVMVTSHVIVVSYIIEYYLFFLLKCSF
SFPTFIRFSFSINN*IPFQFIDLFY*ILPMNFSK
YKKK*FFLHNILSFELHVVSHEYSYC*LNDLYF
TDLILQCKNVSHC*FLSSFH*KNKDLLYGYLIN
I*SLLSKKLSCCYRNNPGRQLSNILMIYFVCN*L
L*EDLDPRY*NKIYFLLYPFQMLKYCLIFLKSL
SIRPCYK*AA*SINRTRDFLLIIQILKVYVMKI
IACVQTLEG*LCCNLACWNV*GEG*LFALLYIVK
REKPV***DLILNKNVYNYKEFC*G*YNDRLSK
IACKSGTELALHTPSNMLLCFLVDSL*FARIFS
AGKIRHPFKPS*LTKTPWGQICLKIITKNSRYFY
H*GEIMDQIFLTFFKTTACLKLQQKKRERTILR
TYIIQISFCQFQWFIVHKKIFKTSIDFHKI*II
NRQTKQHTVAIVVM*LFFNCCRILFFQQVKNKTQ
FKFHGFNFQLRSTQKCKM**WALV*KN*CIQPS
LQLVKNVALISNPTTFIC*KDKCAWFYYYVITT
YFLLVVA*NYVFCLGLQFVLCLFYYYCSS*LCCM
EK*SEIALIKLLFLK

Frame 2

WY*EVPFLTSLLLGTASRAVSAFALLAAS*TVT
TAHPPSTSSPDTPISTYNQEKSSKYLALP*AAL
VLKEKFAEKVRYLLPGNQGGKKKSFSRFCSKLL
HLSMPN*SIPIAPPNSIANSAVRRFPFRQLC*KQ
LGNSVSKGLPRFHACILGSKLALGRGY*EHKAD
TRPYF*TFIYLQS*YFSKNQNLFELTVSCCEFL
VGDLFLDIDDTIFHVLLKQGVGKSILRGHFHHQF
SFFFLVVALFWGGWVCWFH*NI*LPVKSKHGC*
CHTNSGHKMANTGSM*RVPEGDLLTARHGM*IC
TSFEKLPS*KWTSNRLL*FIERPLLQGELQISSS
TPTFKNAVGDKWTQ*LDSAEEHGHVGPANATSQ
CHDAWCPITTRGMSRVPTWQLQPRRK*LSVCSS
C*QHND*HQ*QHSHCVYGLHQREMLSGKVQILSS
PCTFASQDQGCPIPGQPGCSCTGCSHRSCHGNS
SSCTSPITKEACS*KNQRCHRSL*HWYFPIPTG
SSQHAVTTAYSISPTRLNIVHDTRYKCCSHGARC
YASHCVRSNNICHKCSLRCNSHSQPDTHNICRT
SD*PQVCYPDVEFSSLNNHAKEERTVCLVRVKD
EVISHIVYIVKQHTQKFLSHKTSTYCMLTRRKDN
IFRKSTAHCCLYTLYI*LIFVLR*YSCLKEQHC
LSFLAQSYAFKDAYLVSFLYIHAILKRQTMV*P
*FYYVLVRL*TKI*FFKNKFISFKVYK*QRCTLY
LKLPL*MRACMHSHFCLRVIFLM**IVRRGEGG
I*QR*MCQAKPQLCIF*STSWL*VPCC*GFS*S
AIDCTSN*SIISSVLLFSEPHFVAYLLVLISQRA
PFFFFFFETKAVSEMANLTLQ*Q*TAQHKLSQY
R*THTYWRYIYNRYI*NYFNAL*CNIYAYYTV*
HVIQKGLPFLRHSNKKMRKLFCFYL*PLSKVKRL
*MLCKNGFTFA*MLHHSHIQNSDSKQRRKQHCH
QMHDKPKYENGKCLINLVIGWVKYMGEFYM*FL
FCFVLFRLTAYSLRKPFTKLKKK*MCIQFLRMES
SKGIPFFEVWMLQLVKDIFALFSSSKNC*SRGQ
VTGSYSMEWEK*KFSYRTFHTSKFTASFYA*ER
CFLI*D*CVDFTDCTVHLLKP*IITLRVGTHTNV
ISIVLRK*W*LHMLL*LVTL*NITYFSC*NVVF
HFLHLLDFHFLLTIEYHFSL*TCFIRFYQ*IFQ
NTKKSSFSFITYSVLNYM*CHMNIRIVN*MIYIL
LI*YYSVRMSVIVSSCLVFIKRTKIFYMDIL*I
YNHC*VRS*VVAIATILADN*VIF**FILFVIS
YYKKI*ILDIRIKFIFYCIHFKC*NIV*YF*NP*
VSGLVINKLHNQ*IEQGTFC**SKYSKFT**KL
*RVCKLLRVDYAAI*HVGTSREKVDFLHFCI*S
KERNLYNSKILF*IKTSIITRSFVKANTMTD*AK
LLAKVAQS*HSIPLQTCCFAFLWTACSLPGFFQ
LERYAILSNPHD*QKLHGAKSA*RSLPKIAGTS
TIKVKSWIRYSLHFSKLLHV*NFNKKREKELY*E
HILFRSVSANFSGLLFTKKSSKQVLTFTKFKS*
TGKPNSTL*L*LLCDCFLIAVGSCSFSR*KIKR
SSNFMVLIFNSEALKNAKCDNGHLFKRISVSSLH
SSWLKMLHLSATLPLSSAERTNVLGFTIM*SQL
TFCL*LLKIMYFVLGCNLFYAYFIITAVVDFAV
WKNKVKLP**NFSFLS

Sequence NM_021038

TTACATCTTATAGCACCCAGTGAATTATGATATGGGGCTGCGGTTTATTTGCTCTGGCGACAATATGGCTTACTTGCCGTGGAATATCCCGGTATTTCAG
AAGTAACATATTATTTTTAAAGAGGGAGCTTTGCTTTCTCTAAATCACATGGTGCAAAGTTGGGAATACAGTGGCCTGTAAATTACAAATATTATTTACA
AACTAGAAGGAAAGCTGACATGTGTTTGTGCCTGTGTGACAGTTTCACTAAGGAATTCCAAAACTGTGGATAGCCTGTTACTTGAGAAAAATACACGGTG
GCAGTCTTGCAGATGTTTTTCCCGCCTGTTAGCCCTCCAGGTTCAAAAACTGTTTGGTGCATTTTAAGGCGGCAGTCTCACCAGATCGCAGGATTCTAGT
CTAATTGGCTTCTAACCTTCAATCTAACCTTGCCGGCTTCCTTGCAAAGCCCGGTGCAAGGGCCTCTTTCAAAATGAACCCACTGGTGTGCCTAGCAGTC
GGTAGAAGAAGCGGGAGGGCGTCCGGTCTGCACGCCCGCCGCGAGGTTACAATGCTGAACGCATGAGATGGAAGATACCAACGGGAGGCCGAGGGGATCC
ACGGCGCCCGCGCGGGCTCCGGCTTCCTCCTGCTCTCGGCGCCGCTGGGCGACCGCCCATGACCCGCTCTTGCGGGCTCTGTCCGGTTGACAGGCGACCC
TGTGGCCCGGGGAAGCGCGGGAGGGCGCCGGCGGAAAGTTGAAGAGCGTTTTTCTCGCCGCCGCGTGCATTAGGAGCTCGACGAGTCCGCCCTGGGCTTC
CTGGTGGGGCTGGGCGGGCGGGGGAGGGGCCGCGCAGCAGCAGCGGAAGCCAGACCTCGGCGATAAGAGGCTGCACAGCGACATGCAACAGTCTTTTCAC
TGCAGCTGAATGAGTTGTGGCGCCCACAATGCTCCCATGACAAGGAGCTGACAAGTTCCATTTTCCGTCGCGGGCATCTTGGAATCATGACTCCCACAAT
GCCTTGGGCACTTGGTCGACAGTGGGGCCGCCTCTGAAAAAAAAATGTGAGAGGTTGGTACTAAGAAGTGCCTTTCCTGACGTCTCTGCTGCTTGGAACC
GCTTCTAGAGCAGTCTCTGCTTTTGCCTTGCTTGCTGCCAGCTAGACTGTGACGACAGCACATCCACCCTCCACCTCTAGCCCAGACACCCCCATTTCTA
CTTATAATCAAGAGAAAAGCTCTAAGTATCTGGCATTGCCCTAGGCTGCTTTAGTGTTAAAAGAAAAGTTTGCTGAAAAAGTAAGATATCTTCTGCCAGG
AAATCAAGGAGGAAAAAAAAAATCATTTTCTCGATTTTGCTCTAAACTGCTGCATCTGTCTATGCCAAACTAATCAATACCGATTGCACCACCAAACTCC
ATTGCAAATTCAGCTGTGAGGAGATTCCCTTTCAGACAACTTTGCTGAAAGCAGCTTGGAAATTCGGTGTCGAAGGGTCTGCCACGTTTTCATGCTTGCA
TTTTGGGCTCCAAATTGGCACTGGGAAGGGGTTACTGAGAGCACAAGGCTGATACCAGGCCCTACTTTTAAACGTTCATCTACTTACAATCCTAGTATTT
CTCTAAAAACCAAAACCTCTTTGAATTAACAGTTTCATGCTGTGAATTTCTAGTGGGAGATCTTTTCCTTGATATTGACGACACAATTTTCCATGTACTT
TTAAAGCAGGGAGTGGGGAAAAGTATTTTGAGGGGACATTTTCATCATCAGTTCAGCTTTTTTTTTTTGGTTGTTGCTCTTTTTTGGGGGGGTTGGGTTT
GTTGGTTTCACTGAAACATTTAACTACCTGTAAAATCTAAACATGGCTGTTAGTGTCACACCAATTCGGGACACAAAATGGCTAACACTGGAAGTATGTA
GAGAGTTCCAGAGGGGGACTTGCTCACGGCCAGACACGGAATGTAAATTTGCACATCCTTCGAAAAGCTGCCAAGTTGAAAATGGACGAGTAATCGCCTG
CTTTGATTCATTGAAAGGCCGTTGCTCCAGGGAGAACTGCAAATATCTTCATCCACCCCCACATTTAAAAACGCAGTTGGAGATAAATGGACGCAATAAC
TTGATTCAGCAGAAGAACATGGCCATGTTGGCCCAGCAAATGCAACTAGCCAATGCCATGATGCCTGGTGCCCCATTACAACCCGTGCCAATGTTTTCAG
TTGCACCAAGCTTAGCCACCAATGCATCAGCAGCCGCCTTTAATCCCTATCTGGGACCTGTTTCTCCAAGCCTGGTCCCGGCAGAGATCTTGCCGACTGC
ACCAATGTTGGTTACAGGGAATCCGGGTGTCCCTGTACCTGCAGCTGCTGCAGCTGCTGCACAGAAATTAATGCGAACAGACAGACTTGAGGTATGTCGA
GAGTACCAACGTGGCAATTGCAACCGAGGAGAAAATGATTGTCGGTTTGCTCATCCTGCTGACAGCACAATGATTGACACCAATGACAACACAGTCACTG
TGTGTATGGATTACATCAAAGGGAGATGCTCTCGGGAAAAGTGCAAATACTTTCATCCCCCTGCACATTTGCAAGCCAAGATCAAGGCTGCCCAATACCA
GGTCAACCAGGCTGCAGCTGCACAGGCTGCAGCCACCGCAGCTGCCATGGGAATTCCTCAAGCTGTACTTCCCCCATTACCAAAGAGGCCTGCTCTTGAA
AAAACCAACGGTGCCACCGCAGTCTTTAACACTGGTATTTTCCAATACCAACAGGCTCTAGCCAACATGCAGTTACAACAGCATACAGCATTTCTCCCAC
CAGGCTCAATATTGTGCATGACACCCGCTACAAGTGTTGTTCCCATGGTGCACGGTGCTACGCCAGCCACTGTGTCCGCAGCAACAACATCTGCCACAAG
TGTTCCCTTCGCTGCAACAGCCACAGCCAACCAGATACCCATAATATCTGCCGAACATCTGACTAGCCACAAGTATGTTACCCAGATGTAGAATTTTCAT
CACTAAACAATCATGCTAAAGAGGAAAGGACAGTGTGCTTGGTTAGAGTAAAGGACGAGGTCATTAGCCATATTGTATATATCGTCAAGCAACACACACA
AAAGTTCCTCAGCCACAAGACATCCACATATTGCATGTTAACCAGAAGAAAAGACAACATTTTCCGGAAATCCACTGCACACTGTTGCCTATACACTTTG
TACATTTAATTGATATTTGTGCTGAGGTGATATTCCTGTCTAAAAGAACAACATTGTCTTTCTTTTCTAGCACAGAGTTATGCATTCAAAGATGCATACC
TAGTTAGTTTCCTATATATTCATGCCATCTTGAAAAGACAGACTATGGTGTAACCATGATTCTATTATGTATTGGTACGTCTGTAGACCAAGATATAATT
TTTTAAAAATAAGTTTATTTCTTTCAAGGTTTACAAATAACAAAGGTGCACCTTGTATTTAAAATTGCCATTATAGATGAGAGCGTGCATGCACAGTCAT
TTTTGTTTAAGAGTAATATTTTTAATGTAATAGATTGTAAGACGTGGTGAGGGAGGGATCTGACAGAGATGAATGTGCCAAGCAAAACCACAACTGTGTA
TATTTTAAAGCACATCATGGCTTTAAGTACCATGTTGTTAAGGATTCTCATGAAGTGCCATAGACTGTACATCAAATTAGAGTATTATTTCTTCAGTGTT
ATTGTTTTCAGAGCCACATTTTGTTGCATATTTGCTAGTACTAATCAGTCAAAGGGCACCATTCTTTTTTTTTTTTTTTGAAACCAAAGCTGTCTCAGAA
ATGGCCAATTTAACTTTACAGTAACAATAGACAGCACAACACAAACTCTCTCAATACAGATAAACTCACACATACTGGAGATATATATATAATAGATATA
TATAAAATTATTTTAATGCATTGTAGTGTAATATTTATGCATACTATACTGTATAACATGTTATTCAAAAGGGATTGCCATTTCTGAGACACAGTAACAA
AAAAATGAGGAAATTATTTTGCTTCTATTTATAGCCTCTGTCAAAAGTCAAAAGACTATAAATGCTTTGCAAAAATGGTTTCACGTTTGCTTAAATGCTT
CATCACAGTCACATTCAAAATAGTGACTCTAAACAAAGAAGAAAGCAGCACTGTCATCAGATGCATGATAAACCAAAATATGAAAATGGGAAATGTTTAA
TTAACCTAGTAATTGGGTGGGTTAAGTACATGGGTGAATTTTATATGTGATTTTTGTTTTGTTTTGTTTTGTTCAGATTAACTGCTTATAGCCTTAGAAA
GCCTTTTACAAAATTAAAAAAAAAATAGATGTGCATTCAGTTTTTAAGAATGGAATCATCCAAAGGAATTCCTTTTTTTGAGGTTTGGATGTTGCAGCTA
GTAAAGGATATTTTTGCTCTGTTCAGCAGTTCTAAAAATTGCTGAAGTAGGGGCCAGGTCACTGGTAGTTATAGTATGGAATGGGAGAAGTGAAAGTTCA
GTTATAGAACTTTCCATACTTCCAAGTTTACTGCAAGTTTTTATGCTTGAGAGAGATGCTTTCTAATATAAGACTGATGTGTTGATTTTACTGATTGTAC
TGTACATCTATTAAAGCCTTAGATTATTACATTACGGGTTGGAACCCATACCAATGTAATTTCAATCGTGTTAAGAAAGTAATGGTGACTTCACATGTTA
TTGTAGTTAGTTACATTATAGAATATTACTTATTTTTCTTGTTAAAATGTAGTTTTTCATTTCCTACATTTATTAGATTTTCATTTTCTATTAACAATTG
AATACCATTTCAGTTTATAGACTTGTTTTATTAGATTTTACCAATGAATTTTTCAAAATACAAAAAAAAGTAGTTTTTCCTTCATAACATACTCAGTTTT
GAATTACATGTAGTGTCACATGAATATTCGTATTGTTAACTAAATGATTTATATTTTACTGATTTAATATTACAGTGTAAGAATGTCAGTCATTGTTAGT
TCTTGTCTAGTTTTCATTAAAAGAACAAAGATCTTTTATATGGATATCTTATAAATATATAATCATTGCTAAGTAAGAAGTTAAGTTGTTGCTATCGCAA
CAATCCTGGCAGACAATTGAGTAATATTTTGATGATTTATTTTGTTTGTAATTAGTTATTATAAGAAGATCTAGATCCTAGATATTAGAATAAAATTTAT
TTTCTACTGTATCCATTTCAAATGTTAAAATATTGTTTAATATTTTTGAAATCCCTGAGTATCAGGCCTTGTTATAAATAAGCTGCATAATCAATAAATA
GAACAAGGGACTTTTTGTTGATAATCCAAATACTCAAAGTTTACGTAATGAAAATTATAGCGTGTGTGCAAACTCTTGAGGGTTGATTATGCTGCAATTT
AGCATGTTGGAACGTCTAGGGAGAAGGTTGACTTTTTGCACTTCTGTATATAGTCAAAAGAGAGAAACCTGTATAATAGTAAGATCTTATTTTGAATAAA
AACGTCTATAATTACAAGGAGTTTTGTTAAGGCTAATACAATGACAGACTGAGCAAAATTGCTTGCAAAAGTGGCACAGAGTTAGCACTCCATACCCCTT
CAAACATGTTGCTTTGCTTTCTTGTGGACAGCTTGTAGTTTGCCAGGATTTTTTCAGCTGGAAAGATACGCCATCCTTTCAAACCCTCATGACTGACAAA
AACTCCATGGGGCCAAATCTGCCTGAAGATCATTACCAAAAATAGCAGGTACTTCTACCATTAAGGTGAAATCATGGATCAGATATTCCTTACATTTTTC
AAAACTACTGCATGTTTAAAACTTCAACAAAAAAAGAGAGAAAGAACTATACTAAGAACATATATTATTCAGATCAGTTTCTGCCAATTTCAGTGGTTTA
TTGTTCACAAAAAAATCTTCAAAACAAGTATTGACTTTCACAAAATTTAAATCATAAACAGGCAAACCAAACAGCACACTGTAGCTATAGTTGTTATGTG
ATTGTTTTTTAATTGCTGTAGGATCCTGTTCTTTCAGCAGGTGAAAAATAAAACGCAGTTCAAATTTCATGGTTTTAATTTTCAACTCAGAAGCACTCAA
AAATGCAAAATGTGATAATGGGCACTTGTTTAAAAGAATTAGTGTATCCAGCCTTCACTCCAGCTGGTTAAAAATGTTGCACTTATCAGCAACCCTACCA
CTTTCATCTGCTGAAAGGACAAATGTGCTTGGTTTTACTATTATGTAATCACAACTTACTTTCTGCTTGTAGTTGCTTAAAATTATGTATTTTGTCTTGG
GCTGCAATTTGTTTTATGCTTATTTTATTATTACTGCAGTAGTTGACTTTGCTGTATGGAAAAATAAAGTGAAATTGCCCTAATAAAACTTCTCTTTCTT
AAGTA
  • refseq_MBNL1.F7 (forward primer)
  • refseq_MBNL1.R7 (reverse primer)
  • Single exon skipping

Frame 0

LHLIAPSEL*YGAAVYLLWRQYGLLAVEYPGIS
EVTYYF*RGSFAFSKSHGAKLGIQWPVNYKYYLQ
TRRKADMCLCLCDSFTKEFQNCG*PVT*EKYTV
AVLQMFFPPVSPPGSKTVWCILRRQSHQIAGF*
SNWLLTFNLTLPASLQSPVQGPLSK*THWCA*QS
VEEAGGRPVCTPAARLQC*THEMEDTNGRPRGS
TAPARAPASSCSRRRWATAHDPLLRALSG*QAT
LWPGEAREGAGGKLKSVFLAAACIRSSTSPPWAS
WWGWAGGGGAAQQQRKPDLGDKRLHSDMQQSFH
CS*MSCGAHNAPMTRS*QVPFSVAGILES*LPQ
CLGHLVDSGAASEKKM*EVGTKKCLS*RLCCLEP
LLEQSLLLPCLLPARL*RQHIHPPPLAQTPPFL
LIIKRKALSIWHCPRLL*C*KKSLLKK*DIFCQ
EIKEEKKNHFLDFALNCCICLCQTNQYRLHHQTP
LQIQL*GDSLSDNFAESSLEIRCRRVCHVFMLA
FWAPNWHWEGVTESTRLIPGPTFKRSSTYNPSI
SLKTKTSLN*QFHAVNF*WEIFSLILTTQFSMYF
*SREWGKVF*GDIFIISSAFFFWLLLFFGGVGF
VGFTETFNYL*NLNMAVSVTPIRDTKWLTLEVC
REFQRGTCSRPDTECKFAHPSKSCQVENGRVIAC
FDSLKGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFS
VAPSLATNASAAAFNPYLGPVSPSLVPAEILPTA
PMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCR
EYQRGNCNRGENDCRFAHPADSTMIDTNDNTVT
VCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQ
VNQAAAAQAAATAAAMGIPQAVLPPLPKRPALE
KTNGATAVFNTGIFQYQQALANMQLQQHTAFLP
PGSILCMTPATSVVPMVHGATPATVSAATTSATS
VPFAATATANQIPIISAEHLTSHKYVTQM*NFH
H*TIMLKRKGQCAWLE*RTRSLAILYISSSNTH
KSSSATRHPHIAC*PEEKTTFSGNPLHTVAYTLC
TFN*YLC*GDIPV*KNNIVFLF*HRVMHSKMHT
*LVSYIFMPS*KDRLWCNHDSIMYWYVCRPRYN
FLKISLFLSRFTNNKGAPCI*NCHYR*ERACTVI
FV*E*YF*CNRL*DVVREGSDRDECAKQNHNCV
YFKAHHGFKYHVVKDSHEVP*TVHQIRVLFLQC
YCFQSHILLHIC*Y*SVKGHHSFFFFLKPKLSQK
WPI*LYSNNRQHNTNSLNTDKLTHTGDIYIIDI
YKIILMHCSVIFMHTILYNMLFKRDCHF*DTVT
KK*GNYFASIYSLCQKSKDYKCFAKMVSRLLKCF
ITVTFKIVTLNKEESSTVIRCMINQNMKMGNV*
LT**LGGLSTWVNFICDFCFVLFCSD*LLIALE
SLLQN*KKNRCAFSF*EWNHPKEFLFLRFGCCS*
*RIFLLCSAVLKIAEVGARSLVVIVWNGRSESS
VIELSILPSLLQVFMLERDAF*YKTDVLILLIV
LYIY*SLRLLHYGLEPIPM*FQSC*ESNGDFTCY
CS*LHYRILLIFLVKM*FFISYIY*IFIFY*QL
NTISVYRLVLLDFTNEFFKIQKKVVFPS*HTQF
*ITCSVT*IFVLLTK*FIFY*FNITV*ECQSLLV
LV*FSLKEQRSFIWISYKYIIIAK*EVKLLLSQ
QSWQTIE*YFDDLFCL*LVIIRRSRS*ILE*NL
FSTVSISNVKILFNIFEIPEYQALL*ISCIINK*
NKGLFVDNPNTQSLRNENYSVCANS*GLIMLQF
SMLERLGRRLTFCTSVYSQKRETCIIVRSYFE*
KRL*LQGVLLRLIQ*QTEQNCLQKWHRVSTPYPF
KHVALLSCGQLVVCQDFFSWKDTPSFQTLMTDK
NSMGPNLPEDHYQK*QVLLPLR*NHGSDIPYIF
QNYCMFKTSTKKERKNYTKNIYYSDQFLPISVVY
CSQKNLQNKY*LSQNLNHKQANQTAHCSYSCYV
IVF*LL*DPVLSAGEK*NAVQISWF*FSTQKHS
KMQNVIMGTCLKELVYPAFTPAG*KCCTYQQPYH
FHLLKGQMCLVLLLCNHNLLSACSCLKLCILSW
AAICFMLILLLLQ*LTLLYGKIK*NCPNKTSLS
*V

Frame 1

YIL*HPVNYDMGLRFICSGDNMAYLPWNIPVFQ
K*HIIFKEGALLSLNHMVQSWEYSGL*ITNIIY
KLEGKLTCVCACVTVSLRNSKTVDSLLLEKNTRW
QSCRCFSRLLALQVQKLFGAF*GGSLTRSQDSS
LIGF*PSI*PCRLPCKARCKGLFQNEPTGVPSS
R*KKREGVRSARPPRGYNAERMRWKIPTGGRGDP
RRPRGLRLPPALGAAGRPPMTRSCGLCPVDRRP
CGPGKRGRAPAES*RAFFSPPRALGARRVRPGL
PGGAGRAGEGPRSSSGSQTSAIRGCTATCNSLFT
AAE*VVAPTMLP*QGADKFHFPSRASWNHDSHN
ALGTWSTVGPPLKKKCERLVLRSAFPDVSAAWN
RF*SSLCFCLACCQLDCDDSTSTLHL*PRHPHFY
L*SREKL*VSGIALGCFSVKRKVC*KSKISSAR
KSRRKKKIIFSILL*TAASVYAKLINTDCTTKL
HCKFSCEEIPFQTTLLKAAWKFGVEGSATFSCLH
FGLQIGTGKGLLRAQG*YQALLLNVHLLTILVF
L*KPKPL*INSFML*ISSGRSFP*Y*RHNFPCT
FKAGSGEKYFEGTFSSSVQLFFFGCCSFLGGLGL
LVSLKHLTTCKI*TWLLVSHQFGTQNG*HWKYV
ESSRGGLAHGQTRNVNLHILRKAAKLKMDE*SP
ALIH*KAVAPGRTANIFIHPHI*KRSWR*MDAIT
*FSRRTWPCWPSKCN*PMP*CLVPHYNPCQCFQ
LHQA*PPMHQQPPLIPIWDLFLQAWSRQRSCRL
HQCWLQGIRVSLYLQLLQLLHRN*CEQTDLRYVE
STNVAIATEEKMIVGLLILLTAQ*LTPMTTQSL
CVWITSKGDALGKSANTFIPLHICKPRSRLPNT
RSTRLQLHRLQPPQLPWEFLKLYFPHYQRGLLLK
KPTVPPQSLTLVFSNTNRL*PTCSYNSIQHFSH
QAQYCA*HPLQVLFPWCTVLRQPLCPQQQHLPQ
VFPSLQQPQPTRYP*YLPNI*LATSMLPRCRIFI
TKQSC*RGKDSVLG*SKGRGH*PYCIYRQATHT
KVPQPQDIHILHVNQKKRQHFPEIHCTLLPIHF
VHLIDICAEVIFLSKRTTLSFFSSTELCIQRCIP
S*FPIYSCHLEKTDYGVTMILLCIGTSVDQDII
F*K*VYFFQGLQITKVHLVFKIAIIDESVHAQS
FLFKSNIFNVIDCKTW*GRDLTEMNVPSKTTTVY
ILKHIMALSTMLLRILMKCHRLYIKLEYYFFSV
IVFRATFCCIFASTNQSKGTILFFFF*NQSCLR
NGQFNFTVTIDSTTQTLSIQINSHILEIYI**IY
IKLF*CIVV*YLCILYCITCYSKGIAISETQ*Q
KNEEIILLLFIASVKSQKTINALQKWFHVCLNA
SSQSHSK**L*TKKKAALSSDA**TKI*KWEMFN
*PSNWVG*VHG*ILYVIFVLFCFVQINCL*P*K
AFYKIKKKIDVHSVFKNGIIQRNSFF*GLDVAA
SKGYFCSVQQF*KLLK*GPGHW*L*YGMGEVKVQ
L*NFPYFQVYCKFLCLREMLSNIRLMC*FY*LY
CTSIKALDYYITGWNPYQCNFNRVKKVMVTSHV
IVVSYIIEYYLFFLLKCSFSFPTFIRFSFSINN*
IPFQFIDLFY*ILPMNFSKYKKK*FFLHNILSF
ELHVVSHEYSYC*LNDLYFTDLILQCKNVSHC*
FLSSFH*KNKDLLYGYLINI*SLLSKKLSCCYRN
NPGRQLSNILMIYFVCN*LL*EDLDPRY*NKIY
FLLYPFQMLKYCLIFLKSLSIRPCYK*AA*SIN
RTRDFLLIIQILKVYVMKIIACVQTLEG*LCCNL
ACWNV*GEG*LFALLYIVKREKPV***DLILNK
NVYNYKEFC*G*YNDRLSKIACKSGTELALHTP
SNMLLCFLVDSL*FARIFSAGKIRHPFKPS*LTK
TPWGQICLKIITKNSRYFYH*GEIMDQIFLTFF
KTTACLKLQQKKRERTILRTYIIQISFCQFQWF
IVHKKIFKTSIDFHKI*IINRQTKQHTVAIVVM*
LFFNCCRILFFQQVKNKTQFKFHGFNFQLRSTQ
KCKM**WALV*KN*CIQPSLQLVKNVALISNPT
TFIC*KDKCAWFYYYVITTYFLLVVA*NYVFCLG
LQFVLCLFYYYCSS*LCCMEK*SEIALIKLLFL
K

Frame 2

TSYSTQ*IMIWGCGLFALATIWLTCRGISRYFR
SNILFLKRELCFL*ITWCKVGNTVACKLQILFT
N*KES*HVFVPV*QFH*GIPKLWIACYLRKIHG
GSLADVFPAC*PSRFKNCLVHFKAAVSPDRRILV
*LASNLQSNLAGFLAKPGARASFKMNPLVCLAV
GRRSGRASGLHARREVTMLNA*DGRYQREAEGI
HGARAGSGFLLLSAPLGDRP*PALAGSVRLTGDP
VARGSAGGRRRKVEERFSRRRVH*ELDESALGF
LVGLGGRGRGRAAAAEARPRR*EAAQRHATVFS
LQLNELWRPQCSHDKELTSSIFRRGHLGIMTPTM
PWALGRQWGRL*KKNVRGWY*EVPFLTSLLLGT
ASRAVSAFALLAAS*TVTTAHPPSTSSPDTPIS
TYNQEKSSKYLALP*AALVLKEKFAEKVRYLLPG
NQGGKKKSFSRFCSKLLHLSMPN*SIPIAPPNS
IANSAVRRFPFRQLC*KQLGNSVSKGLPRFHAC
ILGSKLALGRGY*EHKADTRPYF*TFIYLQS*YF
SKNQNLFELTVSCCEFLVGDLFLDIDDTIFHVL
LKQGVGKSILRGHFHHQFSFFFLVVALFWGGWV
CWFH*NI*LPVKSKHGC*CHTNSGHKMANTGSM*
RVPEGDLLTARHGM*ICTSFEKLPS*KWTSNRL
L*FIERPLLQGELQISSSTPTFKNAVGDKWTQ*
LDSAEEHGHVGPANATSQCHDAWCPITTRANVFS
CTKLSHQCISSRL*SLSGTCFSKPGPGRDLADC
TNVGYRESGCPCTCSCCSCCTEINANRQT*GMS
RVPTWQLQPRRK*LSVCSSC*QHND*HQ*QHSHC
VYGLHQREMLSGKVQILSSPCTFASQDQGCPIP
GQPGCSCTGCSHRSCHGNSSSCTSPITKEACS*
KNQRCHRSL*HWYFPIPTGSSQHAVTTAYSISPT
RLNIVHDTRYKCCSHGARCYASHCVRSNNICHK
CSLRCNSHSQPDTHNICRTSD*PQVCYPDVEFS
SLNNHAKEERTVCLVRVKDEVISHIVYIVKQHTQ
KFLSHKTSTYCMLTRRKDNIFRKSTAHCCLYTL
YI*LIFVLR*YSCLKEQHCLSFLAQSYAFKDAY
LVSFLYIHAILKRQTMV*P*FYYVLVRL*TKI*F
FKNKFISFKVYK*QRCTLYLKLPL*MRACMHSH
FCLRVIFLM**IVRRGEGGI*QR*MCQAKPQLC
IF*STSWL*VPCC*GFS*SAIDCTSN*SIISSVL
LFSEPHFVAYLLVLISQRAPFFFFFFETKAVSE
MANLTLQ*Q*TAQHKLSQYR*THTYWRYIYNRY
I*NYFNAL*CNIYAYYTV*HVIQKGLPFLRHSNK
KMRKLFCFYL*PLSKVKRL*MLCKNGFTFA*ML
HHSHIQNSDSKQRRKQHCHQMHDKPKYENGKCL
INLVIGWVKYMGEFYM*FLFCFVLFRLTAYSLRK
PFTKLKKK*MCIQFLRMESSKGIPFFEVWMLQL
VKDIFALFSSSKNC*SRGQVTGSYSMEWEK*KF
SYRTFHTSKFTASFYA*ERCFLI*D*CVDFTDCT
VHLLKP*IITLRVGTHTNVISIVLRK*W*LHML
L*LVTL*NITYFSC*NVVFHFLHLLDFHFLLTI
EYHFSL*TCFIRFYQ*IFQNTKKSSFSFITYSVL
NYM*CHMNIRIVN*MIYILLI*YYSVRMSVIVS
SCLVFIKRTKIFYMDIL*IYNHC*VRS*VVAIA
TILADN*VIF**FILFVISYYKKI*ILDIRIKFI
FYCIHFKC*NIV*YF*NP*VSGLVINKLHNQ*I
EQGTFC**SKYSKFT**KL*RVCKLLRVDYAAI
*HVGTSREKVDFLHFCI*SKERNLYNSKILF*IK
TSIITRSFVKANTMTD*AKLLAKVAQS*HSIPL
QTCCFAFLWTACSLPGFFQLERYAILSNPHD*Q
KLHGAKSA*RSLPKIAGTSTIKVKSWIRYSLHFS
KLLHV*NFNKKREKELY*EHILFRSVSANFSGL
LFTKKSSKQVLTFTKFKS*TGKPNSTL*L*LLC
DCFLIAVGSCSFSR*KIKRSSNFMVLIFNSEALK
NAKCDNGHLFKRISVSSLHSSWLKMLHLSATLP
LSSAERTNVLGFTIM*SQLTFCL*LLKIMYFVL
GCNLFYAYFIITAVVDFAVWKNKVKLP**NFSFL
S

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