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Sequences

Sequence NM_153051

GTGAGAAGGCGGCGGCGGCGGCGGAGTAGCAGCCGGACGAGACGTCCCAGCGGCTCAGGCGCTGCCCAGCGCCGGCCCTGGCAGGGAGCCTGGTGGGGTG GCGGAGGGGGAGACTGTGCCGTGGAGGGCCTCGCCATGTCCTGCTGCCCGACTTCCTTGTGAAACCTCCTAGTAGAAAAAGTTCTTGGGACAAACTTCAT TTGACTTCACCATAAGGGAAAGAAGAGAGCCTTGTTGGACACTGAAGAAGGGACGGGGATTTCTCCTCCTAATCTGGGCCTCTTGTCATGGATGAAGAGA CTCGGCACAGCCTTGAGTGCATCCAGGCCAATCAGATCTTTCCCAGGAAGCAGCTGATCCGGGAGGATGAGAATCTTCAGGTTCCTTTCCTTGAACTTCA TGGAGAGAGCACAGAGTTTGTGGGCCGTGCCGAGGATGCCATCATTGCCCTTTCCAATTACAGACTTCACATCAAGTTCAAGGAGTCTCTTGTTAATGTT CCATTACAGCTTATAGAAAGTGTTGAATGCCGAGATATATTTCAGCTTCATTTGACTTGCAAAGACTGCAAAGTTATCAGGTGTCAGTTTTCAACCTTTG AGCAGTGTCAAGAGTGGCTGAAGAGACTGAACAACGCAATCCGACCACCTGCTAAAATAGAAGATCTCTTCTCATTTGCATACCATGCTTGGTGCATGGA GGTCTATGCCAGTGAAAAAGAGCAACATGGAGACCTGTGCAGACCAGGGGAGCATGTAACTTCAAGGTTTAAAAACGAGGTGGAGAGGATGGGTTTTGAT ATGAACAACGCCTGGAGGATTTCCAACATCAATGAGAAGTACAAATTATGTGGTAGCTATCCTCAAGAGCTCATAGTGCCTGCCTGGATCACTGACAAAG AACTGGAAAGTGTATCAAGTTTCAGGTCCTGGAAGCGCATCCCTGCCGTCATCTACAGGCACCAGAGCAATGGAGCTGTCATTGCCCGCTGTGGACAGCC AGAGGTTAGCTGGTGGGGCTGGCGAAATGCAGATGATGAGCATCTGGTACAGTCAGTAGCCAAAGCTTGTGCCTCTGACTCCCGATCGAGTGGCAGCAAG CTGTCAACTAGGAACACTTCTCGAGACTTTCCCAATGGGGGAGACCTTTCTGACGTGGAGTTCGATTCTTCTCTGTCAAATGCTTCAGGAGCAGAGAGTT TAGCCATCCAACCGCAGAAGCTTTTGATCTTGGATGCACGCTCCTATGCAGCTGCTGTGGCAAACCGAGCCAAAGGAGGAGGCTGCGAATGCCCAGAGTA TTACCCAAACTGTGAAGTTGTGTTTATGGGGATGGCAAACATTCATTCTATTCGGAGGAGTTTTCAGTCTCTGCGGTTGCTGTGCACTCAGATGCCAGAT CCGGGAAATTGGCTATCAGCTCTTGAAAGCACAAAATGGCTCCATCACTTGTCTGTGCTTCTGAAATCAGCGCTTCTGGTAGTGCATGCTGTGGATCAGG ATCAGCGGCCGGTGCTAGTACACTGCTCAGATGGCTGGGACCGCACCCCCCAGATTGTGGCATTGGCTAAGCTCTTGCTGGACCCTTATTACCGAACCAT AGAGGGTTTCCAGGTCCTCGTGGAAATGGAGTGGCTGGATTTTGGCCATAAATTTGCTGACCGGTGTGGTCATGGGGAGAACTCGGATGATCTGAATGAA CGTTGCCCAGTGTTTCTGCAGTGGCTTGACTGTGTTCATCAGCTTCAGAGGCAATTTCCTTGCTCTTTTGAGTTCAATGAAGCATTCCTTGTGAAACTGG TGCAGCATACCTATTCCTGCCTGTTTGGAACATTCCTGTGCAACAACGCCAAGGAGAGAGGGGAAAAGCATACTCAGGAACGGACATGTTCCGTGTGGTC ACTTCTTCGGGCAGGCAACAAGGCTTTCAAAAACCTACTGTATTCCTCTCAGTCAGAAGCCGTGCTGTACCCTGTGTGCCATGTGCGTAACCTGATGCTG TGGAGTGCAGTGTACCTGCCCTGCCCATCCCCAACCACCCCTGTGGACGACAGCTGTGCACCATACCCAGCCCCAGGCACCAGCCCTGATGATCCCCCCC TGAGCCGGCTACCAAAGACTAGATCATACGACAATCTGACCACAGCCTGTGACAACACAGTGCCTCTGGCCAGCCGGCGCTGCAGCGACCCCAGCCTGAA CGAGAAGTGGCAGGAGCACCGGCGCTCACTAGAGCTGAGCAGCCTGGCTGGCCCTGGAGAGGATCCCCTTTCTGCCGACAGCCTAGGGAAGCCCACCAGA GTGCCGGGGGGTGCCGAGCTTTCTGTTGCAGCCGGAGTAGCTGAGGGGCAGATGGAGAACATCTTGCAGGAGGCCACCAAAGAGGAGAGTGGAGTAGAGG AACCTGCCCACAGGGCAGGCATTGAGATACAGGAGGGTAAAGAGGACCCTCTCTTAGAAAAGGAGAGCAGGAGGAAGACACCTGAGGCCTCAGCCATTGG ACTTCACCAAGACCCAGAACTGGGTGATGCTGCTCTGAGGAGCCATCTGGATATGAGCTGGCCTCTGTTCTCACAGGGCATTTCTGAACAGCAGAGTGGG CTCAGTGTTCTCCTCAGTTCTCTCCAGGTCCCCCCCAGGGGAGAGGATTCCCTGGAGGTCCCTGTGGAGCAGTTTCGAATAGAAGAGATTGCAGAGGGTA GGGAGGAAGCAGTTCTTCCAATCCCAGTAGATGCAAAAGTTGGCTATGGTACCTCACAGTCATGTTCTCTGCTACCTTCCCAAGTCCCTTTTGAGACCAG AGGACCAAACGTGGACAGTTCTACAGACATGTTAGTGGAAGATAAGGTGAAGTCAGTAAGTGGGCCCCAAGGTCATCATAGATCTTGCCTTGTAAATAGT GGCAAGGACAGGCTTCCTCAGACCATGGAACCCAGCCCTTCAGAGACAAGCCTGGTCGAGAGGCCCCAAGTGGGGTCTGTGGTGCATAGGACTTCCCTTG GCAGCACTCTCAGCCTGACACGTTCCCCTTGTGCCTTGCCTTTAGCCGAATGTAAAGAGGGGCTTGTGTGCAATGGTGCCCCAGAGACTGAAAACAGGGC CTCAGAGCAGCCCCCAGGTCTTAGCACCCTCCAGATGTACCCCACACCCAATGGGCATTGCGCCAATGGGGAGGCTGGTAGGAGCAAGGACTCACTGAGC CGTCAGCTGTCTGCTATGAGCTGCAGCTCTGCCCACTTACACTCAAGGAACTTGCACCACAAGTGGCTGCATAGCCACTCAGGAAGGCCATCTGCAACCA GCAGCCCCGACCAGCCTTCCCGCAGCCACCTGGACGATGATGGCATGTCAGTGTACACAGACACGATCCAACAGCGCCTGCGTCAGATTGAGTCAGGCCA CCAGCAGGAAGTAGAAACTTTGAAGAAACAAGTCCAGGAGCTGAAGAGTCGCCTGGAGAGCCAGTACCTGACCAGCTCCCTACACTTTAATGGAGACTTT GGGGATGAGGTGATGACCCGTTGGCTTCCTGACCACCTGGCCGCCCACTGCTATGCGTGCGACAGTGCCTTCTGGCTTGCCAGCAGGAAGCACCACTGCA GGAATTGTGGGAACGTATTCTGCTCCAGTTGTTGTAACCAGAAGGTTCCAGTTCCCAGCCAGCAGCTCTTTGAACCCAGTCGAGTATGCAAGTCTTGCTA TAGCAGCCTACATCCCACAAGCTCCAGCATTGACCTTGAACTGGATAAGCCCATTGCTGCCACTTCCAACTGAAGCTCAGTGACCTGGGTGGGCAGTGGC CAAGCTGCTGTTCCTATGACAGGCCCACTCAACCTGGGCAGACCGAGAGGCCCGTGCACTTTGGAATGGGAGCGTGGAACCACCTGTACAGAGTGACAGA TTTGGGATGCACCACTGGATTGTAGATTGATTTTTCTTTCCTGTCCCCCTACTCCCTCCCTACCTTTTCCATCCTCCTCCTCTGCCTTCAAAAAAGGAAA CTTTCCCTTGGTTGTCTTAATTTTTTTTTTTTTTGATGGAAGACCAAGGGTTGCCAGGCCCACTGTAACTGCCGAGCTGCCTGCTGTCACGTGACACTGA GGGATGGCTTGTTTCTTCCGGGTGGGAGGATGGTGGTCAGAGCCAGGAGTATGGAGATCTGAGACCGTGAGCAGGGAAGAAAGCCAGTGCTAACATGCAA CCATTCCTCACGCCACCGCCACATCAGAGCTGGTTGGGAACCCTTTGCTGCTGGGGAGGCTGGAAGCATATTCCCCAAGAGCACTGCCCTGGGCATCATC TCCCTCCTGCGAGGAGCTGAGCCAGTCCCCTCACAGATGGATAAATGAGGCTGATGTTTGGAGGGAGAGGCACACGGTAAATGGCATCCCCTTAGGCGCC TCTTTGGGAAAGGAAAGTGGATGCTCCTTTGAGGCAGGCGAGGGGCTGGGAGTGGGTAGCCGTCATGTTGTCCCCCGTGGGATCCCATTTTTAACTTGAC CCAGATTGTCTTGGGCTCCTTTTACTTTCAGGGGGCTGCTTTCCTGGGCCAGGCTGTGTAGCACTTCCCACCCTCAGGCATGAGTACAGACTGGTCAAAA TGTTTATGCAGTCAAGGCCAAAGCCTGCCCTGAGCCCAGACACACCTGGGTCCCCATTCTGGGGCCTGGTCCCCTAAACAATCTCTTCCTCAGCCAGCAC AGGGAAATCCAGACTCAGGGTTCCAGAAATCCCCCGTTCCCAAACCAAACCAATCATGGATCTTCCCTTTAAGGGGTAGAATCAGCCTTTAGAGTTACAA GCCCCTGGAAAAGGGAGCAGGTCCCATACAATCAGCCTTTCTCCTCTTCTCTTCTTGGGACAGGAATAACTGCTGAGCAGTCCCCCTTTGCCACTCCTGG CTGTCTGAGTGGGCACTTGTCTGGCTGCTGGCCAGCAGTGAAGGGCCACTTGGTGACTTCGTAGGGTTCCTTAGAGAAGTGACATGGCCTTGAGGAGATT CAGGGCACCTTTCCTCAGTGAGCTTTGATATGGTCCAAAAACAGCCTTAAATCAAGAATATTTGTGGAGGTAGGTGTGGGGAAGGTTGGAGAAGAGTTAG GTTTGTGCTTTGTAATCTTGGCATCCATGTTTTGTGCCTGCCCTCCCTCTTGGGGAGGCCATGCTTGACTCTGCTGAAAGCTGCTAACTGGTGACAGGGT GGATCATGGTGAGGACTAGGGGTAAGGTCAGGGAATGCTTAAGCTCTGGCCCTGCCCTGTATTCCTCTTCCCCTTGGTAGCAGTTCCCTGACCAAGGGCA AGGTGTGTCTCAGGAAGGTGGTTCTGTGCATGCCTGGGTGTGGTTAAGGCGTGGCCCAGAAGGCTTCCCTGGTGCTCTCAGTCCAGGCAAAGCCCAGAGC ATCTGAGCACGTCTCTGACTTCCAGTGGCAACACAGTTTGAACGTGGTGAAACAGGGTGTAGTTCTTTTCCACATTCTGTGTCATCTAGTCGTGCAGGTA GGGAAAAAGTTGGTCTAATTGAAGATTGTGCATTTCCTAGTGACAGGTGCCAAGAGGTTATGATACGGGTTTCTTGGGTCTGATGTACAGTGTGAATAAA TGCTTGCAGCTCTTAGCTCTTTTTTGATCGATGAAGCACTTTTTTATTAATATTTTCCTTTGTTAAAGGAGGAACCGTAACTCTCCATAGCTGTACATAT AACCCTTTTCTCCTAAAGAGGAGTCAGTCAGTGCTCCTATATTTTTCATTTTTTGTCAAAGCAAGAAGTAAATACTTTAGAATTGTTAAATATATAAATA AAGCAAATAAAGTTGAGTGTTCCACATGGTAGCATTTGCTAACACTTCCTAA

refseq_MTMR3.F1 (forward primer)
refseq_MTMR3.R1 (reverse primer)
Single exon skipping

Frame 0

VRRRRRRRSSSRTRRPSGSGAAQRRPWQGAWWG GGGGDCAVEGLAMSCCPTSL*NLLVEKVLGTNFI *LHHKGKKRALLDTEEGTGISPPNLGLLSWMKR LGTALSASRPIRSFPGSS*SGRMRIFRFLSLNF MERAQSLWAVPRMPSLPFPITDFTSSSRSLLLMF HYSL*KVLNAEIYFSFI*LAKTAKLSGVSFQPL SSVKSG*RD*TTQSDHLLK*KISSHLHTMLGAW RSMPVKKSNMETCADQGSM*LQGLKTRWRGWVLI *TTPGGFPTSMRSTNYVVAILKSS*CLPGSLTK NWKVYQVSGPGSASLPSSTGTRAMELSLPAVDS QRLAGGAGEMQMMSIWYSQ*PKLVPLTPDRVAAS CQLGTLLETFPMGETFLTWSSILLCQMLQEQRV *PSNRRSF*SWMHAPMQLLWQTEPKEEAANAQS ITQTVKLCLWGWQTFILFGGVFSLCGCCALRCQI REIGYQLLKAQNGSITCLCF*NQRFW*CMLWIR ISGRC*YTAQMAGTAPPRLWHWLSSCWTLITEP *RVSRSSWKWSGWILAINLLTGVVMGRTRMI*MN VAQCFCSGLTVFISFRGNFLALLSSMKHSL*NW CSIPIPACLEHSCATTPRREGKSILRNGHVPCG HFFGQATRLSKTYCIPLSQKPCCTLCAMCVT*CC GVQCTCPAHPQPPLWTTAVHHTQPQAPALMIPP *AGYQRLDHTTI*PQPVTTQCLWPAGAAATPA* TRSGRSTGAH*S*AAWLALERIPFLPTA*GSPPE CRGVPSFLLQPE*LRGRWRTSCRRPPKRRVE*R NLPTGQALRYRRVKRTLS*KRRAGGRHLRPQPL DFTKTQNWVMLL*GAIWI*AGLCSHRAFLNSRVG SVFSSVLSRSPPGERIPWRSLWSSFE*KRLQRV GRKQFFQSQ*MQKLAMVPHSHVLCYLPKSLLRP EDQTWTVLQTC*WKIR*SQ*VGPKVIIDLAL*IV ARTGFLRPWNPALQRQAWSRGPKWGLWCIGLPL AALSA*HVPLVPCL*PNVKRGLCAMVPQRLKTG PQSSPQVLAPSRCTPHPMGIAPMGRLVGARTH*A VSCLL*AAALPTYTQGTCTTSGCIATQEGHLQP AAPTSLPAATWTMMACQCTQTRSNSACVRLSQA TSRK*KL*RNKSRS*RVAWRAST*PAPYTLMETL GMR**PVGFLTTWPPTAMRATVPSGLPAGSTTA GIVGTYSAPVVVTRRFQFPASSSLNPVEYASLA IAAYIPQAPALTLNWISPLLPLPTEAQ*PGWAVA KLLFL*QAHSTWADREARALWNGSVEPPVQSDR FGMHHWIVD*FFFPVPLLPPYLFHPPPLPSKKE TFPWLS*FFFFLMEDQGLPGPL*LPSCLLSRDTE GWLVSSGWEDGGQSQEYGDLRP*AGKKASANMQ PFLTPPPHQSWLGTLCCWGGWKHIPQEHCPGHH LPPARS*ASPLTDG*MRLMFGGRGTR*MASP*AP LWERKVDAPLRQARGWEWVAVMLSPVGSHF*LD PDCLGLLLLSGGCFPGPGCVALPTLRHEYRLVK MFMQSRPKPALSPDTPGSPFWGLVP*TISSSAST GKSRLRVPEIPRSQTKPIMDLPFKG*NQPLELQ APGKGSRSHTISLSPLLFLGQE*LLSSPPLPLL AV*VGTCLAAGQQ*RATW*LRRVP*RSDMALRRF RAPFLSEL*YGPKTALNQEYLWR*VWGRLEKS* VCAL*SWHPCFVPALPLGEAMLDSAESC*LVTG WIMVRTRGKVRECLSSGPALYSSSPW*QFPDQGQ GVSQEGGSVHAWVWLRRGPEGFPGALSPGKAQS I*ARL*LPVATQFERGETGCSSFPHSVSSSRAG REKVGLIEDCAFPSDRCQEVMIRVSWV*CTV*IN ACSS*LFFDR*STFLLIFSFVKGGTVTLHSCTY NPFLLKRSQSVLLYFSFFVKARSKYFRIVKYIN KANKVECSTW*HLLTLP

Frame 1

*EGGGGGGVAAGRDVPAAQALPSAGPGREPGGV AEGETVPWRASPCPAARLPCETS**KKFLGQTS FDFTIRERREPCWTLKKGRGFLLLIWASCHG*RD SAQP*VHPGQSDLSQEAADPGG*ESSGSFP*TS WREHRVCGPCRGCHHCPFQLQTSHQVQGVSC*C SITAYRKC*MPRYISASFDLQRLQSYQVSVFNL* AVSRVAEETEQRNPTTC*NRRSLLICIPCLVHG GLCQ*KRATWRPVQTRGACNFKV*KRGGEDGF* YEQRLEDFQHQ*EVQIMW*LSSRAHSACLDH*QR TGKCIKFQVLEAHPCRHLQAPEQWSCHCPLWTA RG*LVGLAKCR**ASGTVSSQSLCL*LPIEWQQ AVN*EHFSRLSQWGRPF*RGVRFFSVKCFRSREF SHPTAEAFDLGCTLLCSCCGKPSQRRRLRMPRV LPKL*SCVYGDGKHSFYSEEFSVSAVAVHSDAR SGKLAISS*KHKMAPSLVCASEISASGSACCGSG SAAGASTLLRWLGPHPPDCGIG*ALAGPLLPNH RGFPGPRGNGVAGFWP*IC*PVWSWGELG*SE* TLPSVSAVA*LCSSASEAISLLF*VQ*SIPCETG AAYLFLPVWNIPVQQRQGERGKAYSGTDMFRVV TSSGRQQGFQKPTVFLSVRSRAVPCVPCA*PDA VECSVPALPIPNHPCGRQLCTIPSPRHQP**SPP EPATKD*IIRQSDHSL*QHSASGQPALQRPQPE REVAGAPALTRAEQPGWPWRGSPFCRQPREAHQ SAGGCRAFCCSRSS*GADGEHLAGGHQRGEWSRG TCPQGRH*DTGG*RGPSLRKGEQEEDT*GLSHW TSPRPRTG*CCSEEPSGYELASVLTGHF*TAEW AQCSPQFSPGPPQGRGFPGGPCGAVSNRRDCRG* GGSSSSNPSRCKSWLWYLTVMFSATFPSPF*DQ RTKRGQFYRHVSGR*GEVSKWAPRSS*ILPCK* WQGQASSDHGTQPFRDKPGREAPSGVCGA*DFPW QHSQPDTFPLCLAFSRM*RGACVQWCPRD*KQG LRAAPRS*HPPDVPHTQWALRQWGGW*EQGLTE PSAVCYELQLCPLTLKELAPQVAA*PLRKAICNQ QPRPAFPQPPGR*WHVSVHRHDPTAPASD*VRP PAGSRNFEETSPGAEESPGEPVPDQLPTL*WRL WG*GDDPLAS*PPGRPLLCVRQCLLACQQEAPLQ ELWERILLQLL*PEGSSSQPAAL*TQSSMQVLL *QPTSHKLQH*P*TG*AHCCHFQLKLSDLGGQW PSCCSYDRPTQPGQTERPVHFGMGAWNHLYRVTD LGCTTGL*IDFSFLSPYSLPTFSILLLCLQKRK LSLGCLNFFFF*WKTKGCQAHCNCRAACCHVTL RDGLFLPGGRMVVRARSMEI*DREQGRKPVLTCN HSSRHRHIRAGWEPFAAGEAGSIFPKSTALGII SLLRGAEPVPSQMDK*G*CLEGEAHGKWHPLRR LFGKGKWMLL*GRRGAGSG*PSCCPPWDPIFNLT QIVLGSFYFQGAAFLGQAV*HFPPSGMSTDWSK CLCSQGQSLP*AQTHLGPHSGAWSPKQSLPQPA QGNPDSGFQKSPVPKPNQSWIFPLRGRISL*SYK PLEKGAGPIQSAFLLFSSWDRNNC*AVPLCHSW LSEWALVWLLASSEGPLGDFVGFLREVTWP*GD SGHLSSVSFDMVQKQP*IKNICGGRCGEGWRRVR FVLCNLGIHVLCLPSLLGRPCLTLLKAANW*QG GSW*GLGVRSGNA*ALALPCIPLPLGSSSLTKG KVCLRKVVLCMPGCG*GVAQKASLVLSVQAKPRA SEHVSDFQWQHSLNVVKQGVVLFHILCHLVVQV GKKLV*LKIVHFLVTGAKRL*YGFLGSDVQCE* MLAALSSFLIDEALFY*YFPLLKEEP*LSIAVHI TLFS*RGVSQCSYIFHFLSKQEVNTLELLNI*I KQIKLSVPHGSIC*HFL

Frame 2

EKAAAAAE*QPDETSQRLRRCPAPALAGSLVGW RRGRLCRGGPRHVLLPDFLVKPPSRKSSWDKLH LTSP*GKEESLVGH*RRDGDFSS*SGPLVMDEE TRHSLECIQANQIFPRKQLIREDENLQVPFLELH GESTEFVGRAEDAIIALSNYRLHIKFKESLVNV PLQLIESVECRDIFQLHLTCKDCKVIRCQFSTF EQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCME VYASEKEQHGDLCRPGEHVTSRFKNEVERMGFD MNNAWRISNINEKYKLCGSYPQELIVPAWITDK ELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQP EVSWWGWRNADDEHLVQSVAKACASDSRSSGSK LSTRNTSRDFPNGGDLSDVEFDSSLSNASGAES LAIQPQKLLILDARSYAAAVANRAKGGGCECPEY YPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPD PGNWLSALESTKWLHHLSVLLKSALLVVHAVDQ DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTI EGFQVLVEMEWLDFGHKFADRCGHGENSDDLNE RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKL VQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWS LLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLML WSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPP LSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLN EKWQEHRRSLELSSLAGPGEDPLSADSLGKPTR VPGGAELSVAAGVAEGQMENILQEATKEESGVE EPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIG LHQDPELGDAALRSHLDMSWPLFSQGISEQQSG LSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEG REEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETR GPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNS GKDRLPQTMEPSPSETSLVERPQVGSVVHRTSL GSTLSLTRSPCALPLAECKEGLVCNGAPETENRA SEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLS RQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSAT SSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGH QQEVETLKKQVQELKSRLESQYLTSSLHFNGDF GDEVMTRWLPDHLAAHCYACDSAFWLASRKHHC RNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCY SSLHPTSSSIDLELDKPIAATSN*SSVTWVGSG QAAVPMTGPLNLGRPRGPCTLEWERGTTCTE*Q IWDAPLDCRLIFLSCPPTPSLPFPSSSSAFKKGN FPLVVLIFFFFDGRPRVARPTVTAELPAVT*H* GMACFFRVGGWWSEPGVWRSETVSREESQC*HA TIPHATATSELVGNPLLLGRLEAYSPRALPWASS PSCEELSQSPHRWINEADVWRERHTVNGIPLGA SLGKESGCSFEAGEGLGVGSRHVVPRGIPFLT* PRLSWAPFTFRGLLSWARLCSTSHPQA*VQTGQN VYAVKAKACPEPRHTWVPILGPGPLNNLFLSQH REIQTQGSRNPPFPNQTNHGSSL*GVESAFRVT SPWKREQVPYNQPFSSSLLGTGITAEQSPFATPG CLSGHLSGCWPAVKGHLVTS*GSLEK*HGLEEI QGTFPQ*ALIWSKNSLKSRIFVEVGVGKVGEEL GLCFVILASMFCACPPSWGGHA*LC*KLLTGDRV DHGED*G*GQGMLKLWPCPVFLFPLVAVP*PRA RCVSGRWFCACLGVVKAWPRRLPWCSQSRQSPE HLSTSLTSSGNTV*TW*NRV*FFSTFCVI*SCR* GKSWSN*RLCIS**QVPRGYDTGFLGLMYSVNK CLQLLALF*SMKHFFINIFLC*RRNRNSP*LYI *PFSPKEESVSAPIFFIFCQSKK*IL*NC*IYK* SK*S*VFHMVAFANTS*

Sequence NM_021090

GTGAGAAGGCGGCGGCGGCGGCGGAGTAGCAGCCGGACGAGACGTCCCAGCGGCTCAGGCGCTGCCCAGCGCCGGCCCTGGCAGGGAGCCTGGTGGGGTG GCGGAGGGGGAGACTGTGCCGTGGAGGGCCTCGCCATGTCCTGCTGCCCGACTTCCTTGTGAAACCTCCTAGTAGAAAAAGTTCTTGGGACAAACTTCAT TTGACTTCACCATAAGGGAAAGAAGAGAGCCTTGTTGGACACTGAAGAAGGGACGGGGATTTCTCCTCCTAATCTGGGCCTCTTGTCATGGATGAAGAGA CTCGGCACAGCCTTGAGTGCATCCAGGCCAATCAGATCTTTCCCAGGAAGCAGCTGATCCGGGAGGATGAGAATCTTCAGGTTCCTTTCCTTGAACTTCA TGGAGAGAGCACAGAGTTTGTGGGCCGTGCCGAGGATGCCATCATTGCCCTTTCCAATTACAGACTTCACATCAAGTTCAAGGAGTCTCTTGTTAATGTT CCATTACAGCTTATAGAAAGTGTTGAATGCCGAGATATATTTCAGCTTCATTTGACTTGCAAAGACTGCAAAGTTATCAGGTGTCAGTTTTCAACCTTTG AGCAGTGTCAAGAGTGGCTGAAGAGACTGAACAACGCAATCCGACCACCTGCTAAAATAGAAGATCTCTTCTCATTTGCATACCATGCTTGGTGCATGGA GGTCTATGCCAGTGAAAAAGAGCAACATGGAGACCTGTGCAGACCAGGGGAGCATGTAACTTCAAGGTTTAAAAACGAGGTGGAGAGGATGGGTTTTGAT ATGAACAACGCCTGGAGGATTTCCAACATCAATGAGAAGTACAAATTATGTGGTAGCTATCCTCAAGAGCTCATAGTGCCTGCCTGGATCACTGACAAAG AACTGGAAAGTGTATCAAGTTTCAGGTCCTGGAAGCGCATCCCTGCCGTCATCTACAGGCACCAGAGCAATGGAGCTGTCATTGCCCGCTGTGGACAGCC AGAGGTTAGCTGGTGGGGCTGGCGAAATGCAGATGATGAGCATCTGGTACAGTCAGTAGCCAAAGCTTGTGCCTCTGACTCCCGATCGAGTGGCAGCAAG CTGTCAACTAGGAACACTTCTCGAGACTTTCCCAATGGGGGAGACCTTTCTGACGTGGAGTTCGATTCTTCTCTGTCAAATGCTTCAGGAGCAGAGAGTT TAGCCATCCAACCGCAGAAGCTTTTGATCTTGGATGCACGCTCCTATGCAGCTGCTGTGGCAAACCGAGCCAAAGGAGGAGGCTGCGAATGCCCAGAGTA TTACCCAAACTGTGAAGTTGTGTTTATGGGGATGGCAAACATTCATTCTATTCGGAGGAGTTTTCAGTCTCTGCGGTTGCTGTGCACTCAGATGCCAGAT CCGGGAAATTGGCTATCAGCTCTTGAAAGCACAAAATGGCTCCATCACTTGTCTGTGCTTCTGAAATCAGCGCTTCTGGTAGTGCATGCTGTGGATCAGG ATCAGCGGCCGGTGCTAGTACACTGCTCAGATGGCTGGGACCGCACCCCCCAGATTGTGGCATTGGCTAAGCTCTTGCTGGACCCTTATTACCGAACCAT AGAGGGTTTCCAGGTCCTCGTGGAAATGGAGTGGCTGGATTTTGGCCATAAATTTGCTGACCGGTGTGGTCATGGGGAGAACTCGGATGATCTGAATGAA CGTTGCCCAGTGTTTCTGCAGTGGCTTGACTGTGTTCATCAGCTTCAGAGGCAATTTCCTTGCTCTTTTGAGTTCAATGAAGCATTCCTTGTGAAACTGG TGCAGCATACCTATTCCTGCCTGTTTGGAACATTCCTGTGCAACAACGCCAAGGAGAGAGGGGAAAAGCATACTCAGGAACGGACATGTTCCGTGTGGTC ACTTCTTCGGGCAGGCAACAAGGCTTTCAAAAACCTACTGTATTCCTCTCAGTCAGAAGCCGTGCTGTACCCTGTGTGCCATGTGCGTAACCTGATGCTG TGGAGTGCAGTGTACCTGCCCTGCCCATCCCCAACCACCCCTGTGGACGACAGCTGTGCACCATACCCAGCCCCAGGCACCAGCCCTGATGATCCCCCCC TGAGCCGGCTACCAAAGACTAGATCATACGACAATCTGACCACAGCCTGTGACAACACAGTGCCTCTGGCCAGCCGGCGCTGCAGCGACCCCAGCCTGAA CGAGAAGTGGCAGGAGCACCGGCGCTCACTAGAGCTGAGCAGCCTGGCTGGCCCTGGAGAGGATCCCCTTTCTGCCGACAGCCTAGGGAAGCCCACCAGA GTGCCGGGGGGTGCCGAGCTTTCTGTTGCAGCCGGAGTAGCTGAGGGGCAGATGGAGAACATCTTGCAGGAGGCCACCAAAGAGGAGAGTGGAGTAGAGG AACCTGCCCACAGGGCAGGCATTGAGATACAGGAGGGTAAAGAGGACCCTCTCTTAGAAAAGGAGAGCAGGAGGAAGACACCTGAGGCCTCAGCCATTGG ACTTCACCAAGACCCAGAACTGGGTGATGCTGCTCTGAGGAGCCATCTGGATATGAGCTGGCCTCTGTTCTCACAGGGCATTTCTGAACAGCAGAGTGGG CTCAGTGTTCTCCTCAGTTCTCTCCAGGTCCCCCCCAGGGGAGAGGATTCCCTGGAGGTCCCTGTGGAGCAGTTTCGAATAGAAGAGATTGCAGAGGGTA GGGAGGAAGCAGTTCTTCCAATCCCAGTAGATGCAAAAGTTGGCTATGGTACCTCACAGTCATGTTCTCTGCTACCTTCCCAAGTCCCTTTTGAGACCAG AGGACCAAACGTGGACAGTTCTACAGACATGTTAGTGGAAGATAAGGTGAAGTCAGTAAGTGGGCCCCAAGGTCATCATAGATCTTGCCTTGTAAATAGT GGCAAGGACAGGCTTCCTCAGACCATGGAACCCAGCCCTTCAGAGACAAGCCTGGTCGAGAGGCCCCAAGTGGGGTCTGTGGTGCATAGGACTTCCCTTG GCAGCACTCTCAGCCTGACACGTTCCCCTTGTGCCTTGCCTTTAGCCGAATGTAAAGAGGGGCTTGTGTGCAATGGTGCCCCAGAGACTGAAAACAGGGC CTCAGAGCAGCCCCCAGGTCTTAGCACCCTCCAGATGTACCCCACACCCAATGGGCATTGCGCCAATGGGGAGGCTGGTAGGAGCAAGGACTCACTGAGC CGTCAGCTGTCTGCTATGAGCTGCAGCTCTGCCCACTTACACTCAAGGAACTTGCACCACAAGTGGCTGCATAGCCACTCAGGAAGGCCATCTGCAACCA GCAGCCCCGACCAGCCTTCCCGCAGCCACCTGGACGATGATGGCATGTCAGTGTACACAGACACGATCCAACAGCGCCTGCGTCAGATTGAGTCAGGCCA CCAGCAGGAAGTAGAAACTTTGAAGAAACAAGTCCAGGAGCTGAAGAGTCGCCTGGAGAGCCAGTACCTGACCAGCTCCCTACACTTTAATGGAGACTTT GGGGATGAGGTGACTTCAATCCCCGACTCGGAAAGCAATCTGGATCAGAACTGTTTGTCTCGCTGCAGCACAGAGATTTTCTCTGAAGCCAGCTGGGAGC AGGTGGATAAACAGGACACAGAGATGACCCGTTGGCTTCCTGACCACCTGGCCGCCCACTGCTATGCGTGCGACAGTGCCTTCTGGCTTGCCAGCAGGAA GCACCACTGCAGGAATTGTGGGAACGTATTCTGCTCCAGTTGTTGTAACCAGAAGGTTCCAGTTCCCAGCCAGCAGCTCTTTGAACCCAGTCGAGTATGC AAGTCTTGCTATAGCAGCCTACATCCCACAAGCTCCAGCATTGACCTTGAACTGGATAAGCCCATTGCTGCCACTTCCAACTGAAGCTCAGTGACCTGGG TGGGCAGTGGCCAAGCTGCTGTTCCTATGACAGGCCCACTCAACCTGGGCAGACCGAGAGGCCCGTGCACTTTGGAATGGGAGCGTGGAACCACCTGTAC AGAGTGACAGATTTGGGATGCACCACTGGATTGTAGATTGATTTTTCTTTCCTGTCCCCCTACTCCCTCCCTACCTTTTCCATCCTCCTCCTCTGCCTTC AAAAAAGGAAACTTTCCCTTGGTTGTCTTAATTTTTTTTTTTTTTGATGGAAGACCAAGGGTTGCCAGGCCCACTGTAACTGCCGAGCTGCCTGCTGTCA CGTGACACTGAGGGATGGCTTGTTTCTTCCGGGTGGGAGGATGGTGGTCAGAGCCAGGAGTATGGAGATCTGAGACCGTGAGCAGGGAAGAAAGCCAGTG CTAACATGCAACCATTCCTCACGCCACCGCCACATCAGAGCTGGTTGGGAACCCTTTGCTGCTGGGGAGGCTGGAAGCATATTCCCCAAGAGCACTGCCC TGGGCATCATCTCCCTCCTGCGAGGAGCTGAGCCAGTCCCCTCACAGATGGATAAATGAGGCTGATGTTTGGAGGGAGAGGCACACGGTAAATGGCATCC CCTTAGGCGCCTCTTTGGGAAAGGAAAGTGGATGCTCCTTTGAGGCAGGCGAGGGGCTGGGAGTGGGTAGCCGTCATGTTGTCCCCCGTGGGATCCCATT TTTAACTTGACCCAGATTGTCTTGGGCTCCTTTTACTTTCAGGGGGCTGCTTTCCTGGGCCAGGCTGTGTAGCACTTCCCACCCTCAGGCATGAGTACAG ACTGGTCAAAATGTTTATGCAGTCAAGGCCAAAGCCTGCCCTGAGCCCAGACACACCTGGGTCCCCATTCTGGGGCCTGGTCCCCTAAACAATCTCTTCC TCAGCCAGCACAGGGAAATCCAGACTCAGGGTTCCAGAAATCCCCCGTTCCCAAACCAAACCAATCATGGATCTTCCCTTTAAGGGGTAGAATCAGCCTT TAGAGTTACAAGCCCCTGGAAAAGGGAGCAGGTCCCATACAATCAGCCTTTCTCCTCTTCTCTTCTTGGGACAGGAATAACTGCTGAGCAGTCCCCCTTT GCCACTCCTGGCTGTCTGAGTGGGCACTTGTCTGGCTGCTGGCCAGCAGTGAAGGGCCACTTGGTGACTTCGTAGGGTTCCTTAGAGAAGTGACATGGCC TTGAGGAGATTCAGGGCACCTTTCCTCAGTGAGCTTTGATATGGTCCAAAAACAGCCTTAAATCAAGAATATTTGTGGAGGTAGGTGTGGGGAAGGTTGG AGAAGAGTTAGGTTTGTGCTTTGTAATCTTGGCATCCATGTTTTGTGCCTGCCCTCCCTCTTGGGGAGGCCATGCTTGACTCTGCTGAAAGCTGCTAACT GGTGACAGGGTGGATCATGGTGAGGACTAGGGGTAAGGTCAGGGAATGCTTAAGCTCTGGCCCTGCCCTGTATTCCTCTTCCCCTTGGTAGCAGTTCCCT GACCAAGGGCAAGGTGTGTCTCAGGAAGGTGGTTCTGTGCATGCCTGGGTGTGGTTAAGGCGTGGCCCAGAAGGCTTCCCTGGTGCTCTCAGTCCAGGCA AAGCCCAGAGCATCTGAGCACGTCTCTGACTTCCAGTGGCAACACAGTTTGAACGTGGTGAAACAGGGTGTAGTTCTTTTCCACATTCTGTGTCATCTAG TCGTGCAGGTAGGGAAAAAGTTGGTCTAATTGAAGATTGTGCATTTCCTAGTGACAGGTGCCAAGAGGTTATGATACGGGTTTCTTGGGTCTGATGTACA GTGTGAATAAATGCTTGCAGCTCTTAGCTCTTTTTTGATCGATGAAGCACTTTTTTATTAATATTTTCCTTTGTTAAAGGAGGAACCGTAACTCTCCATA GCTGTACATATAACCCTTTTCTCCTAAAGAGGAGTCAGTCAGTGCTCCTATATTTTTCATTTTTTGTCAAAGCAAGAAGTAAATACTTTAGAATTGTTAA ATATATAAATAAAGCAAATAAAGTTGAGTGTTCCACATGGTAGCATTTGCTAACACTTCCTAA

refseq_MTMR3.F1 (forward primer)
refseq_MTMR3.R1 (reverse primer)
Single exon skipping

Frame 0

VRRRRRRRSSSRTRRPSGSGAAQRRPWQGAWWG GGGGDCAVEGLAMSCCPTSL*NLLVEKVLGTNFI *LHHKGKKRALLDTEEGTGISPPNLGLLSWMKR LGTALSASRPIRSFPGSS*SGRMRIFRFLSLNF MERAQSLWAVPRMPSLPFPITDFTSSSRSLLLMF HYSL*KVLNAEIYFSFI*LAKTAKLSGVSFQPL SSVKSG*RD*TTQSDHLLK*KISSHLHTMLGAW RSMPVKKSNMETCADQGSM*LQGLKTRWRGWVLI *TTPGGFPTSMRSTNYVVAILKSS*CLPGSLTK NWKVYQVSGPGSASLPSSTGTRAMELSLPAVDS QRLAGGAGEMQMMSIWYSQ*PKLVPLTPDRVAAS CQLGTLLETFPMGETFLTWSSILLCQMLQEQRV *PSNRRSF*SWMHAPMQLLWQTEPKEEAANAQS ITQTVKLCLWGWQTFILFGGVFSLCGCCALRCQI REIGYQLLKAQNGSITCLCF*NQRFW*CMLWIR ISGRC*YTAQMAGTAPPRLWHWLSSCWTLITEP *RVSRSSWKWSGWILAINLLTGVVMGRTRMI*MN VAQCFCSGLTVFISFRGNFLALLSSMKHSL*NW CSIPIPACLEHSCATTPRREGKSILRNGHVPCG HFFGQATRLSKTYCIPLSQKPCCTLCAMCVT*CC GVQCTCPAHPQPPLWTTAVHHTQPQAPALMIPP *AGYQRLDHTTI*PQPVTTQCLWPAGAAATPA* TRSGRSTGAH*S*AAWLALERIPFLPTA*GSPPE CRGVPSFLLQPE*LRGRWRTSCRRPPKRRVE*R NLPTGQALRYRRVKRTLS*KRRAGGRHLRPQPL DFTKTQNWVMLL*GAIWI*AGLCSHRAFLNSRVG SVFSSVLSRSPPGERIPWRSLWSSFE*KRLQRV GRKQFFQSQ*MQKLAMVPHSHVLCYLPKSLLRP EDQTWTVLQTC*WKIR*SQ*VGPKVIIDLAL*IV ARTGFLRPWNPALQRQAWSRGPKWGLWCIGLPL AALSA*HVPLVPCL*PNVKRGLCAMVPQRLKTG PQSSPQVLAPSRCTPHPMGIAPMGRLVGARTH*A VSCLL*AAALPTYTQGTCTTSGCIATQEGHLQP AAPTSLPAATWTMMACQCTQTRSNSACVRLSQA TSRK*KL*RNKSRS*RVAWRAST*PAPYTLMETL GMR*LQSPTRKAIWIRTVCLAAAQRFSLKPAGS RWINRTQR*PVGFLTTWPPTAMRATVPSGLPAG STTAGIVGTYSAPVVVTRRFQFPASSSLNPVEYA SLAIAAYIPQAPALTLNWISPLLPLPTEAQ*PG WAVAKLLFL*QAHSTWADREARALWNGSVEPPV QSDRFGMHHWIVD*FFFPVPLLPPYLFHPPPLPS KKETFPWLS*FFFFLMEDQGLPGPL*LPSCLLS RDTEGWLVSSGWEDGGQSQEYGDLRP*AGKKAS ANMQPFLTPPPHQSWLGTLCCWGGWKHIPQEHCP GHHLPPARS*ASPLTDG*MRLMFGGRGTR*MAS P*APLWERKVDAPLRQARGWEWVAVMLSPVGSH F*LDPDCLGLLLLSGGCFPGPGCVALPTLRHEYR LVKMFMQSRPKPALSPDTPGSPFWGLVP*TISS SASTGKSRLRVPEIPRSQTKPIMDLPFKG*NQP LELQAPGKGSRSHTISLSPLLFLGQE*LLSSPPL PLLAV*VGTCLAAGQQ*RATW*LRRVP*RSDMA LRRFRAPFLSEL*YGPKTALNQEYLWR*VWGRL EKS*VCAL*SWHPCFVPALPLGEAMLDSAESC*L VTGWIMVRTRGKVRECLSSGPALYSSSPW*QFP DQGQGVSQEGGSVHAWVWLRRGPEGFPGALSPG KAQSI*ARL*LPVATQFERGETGCSSFPHSVSSS RAGREKVGLIEDCAFPSDRCQEVMIRVSWV*CT V*INACSS*LFFDR*STFLLIFSFVKGGTVTLH SCTYNPFLLKRSQSVLLYFSFFVKARSKYFRIVK YINKANKVECSTW*HLLTLP

Frame 1

*EGGGGGGVAAGRDVPAAQALPSAGPGREPGGV AEGETVPWRASPCPAARLPCETS**KKFLGQTS FDFTIRERREPCWTLKKGRGFLLLIWASCHG*RD SAQP*VHPGQSDLSQEAADPGG*ESSGSFP*TS WREHRVCGPCRGCHHCPFQLQTSHQVQGVSC*C SITAYRKC*MPRYISASFDLQRLQSYQVSVFNL* AVSRVAEETEQRNPTTC*NRRSLLICIPCLVHG GLCQ*KRATWRPVQTRGACNFKV*KRGGEDGF* YEQRLEDFQHQ*EVQIMW*LSSRAHSACLDH*QR TGKCIKFQVLEAHPCRHLQAPEQWSCHCPLWTA RG*LVGLAKCR**ASGTVSSQSLCL*LPIEWQQ AVN*EHFSRLSQWGRPF*RGVRFFSVKCFRSREF SHPTAEAFDLGCTLLCSCCGKPSQRRRLRMPRV LPKL*SCVYGDGKHSFYSEEFSVSAVAVHSDAR SGKLAISS*KHKMAPSLVCASEISASGSACCGSG SAAGASTLLRWLGPHPPDCGIG*ALAGPLLPNH RGFPGPRGNGVAGFWP*IC*PVWSWGELG*SE* TLPSVSAVA*LCSSASEAISLLF*VQ*SIPCETG AAYLFLPVWNIPVQQRQGERGKAYSGTDMFRVV TSSGRQQGFQKPTVFLSVRSRAVPCVPCA*PDA VECSVPALPIPNHPCGRQLCTIPSPRHQP**SPP EPATKD*IIRQSDHSL*QHSASGQPALQRPQPE REVAGAPALTRAEQPGWPWRGSPFCRQPREAHQ SAGGCRAFCCSRSS*GADGEHLAGGHQRGEWSRG TCPQGRH*DTGG*RGPSLRKGEQEEDT*GLSHW TSPRPRTG*CCSEEPSGYELASVLTGHF*TAEW AQCSPQFSPGPPQGRGFPGGPCGAVSNRRDCRG* GGSSSSNPSRCKSWLWYLTVMFSATFPSPF*DQ RTKRGQFYRHVSGR*GEVSKWAPRSS*ILPCK* WQGQASSDHGTQPFRDKPGREAPSGVCGA*DFPW QHSQPDTFPLCLAFSRM*RGACVQWCPRD*KQG LRAAPRS*HPPDVPHTQWALRQWGGW*EQGLTE PSAVCYELQLCPLTLKELAPQVAA*PLRKAICNQ QPRPAFPQPPGR*WHVSVHRHDPTAPASD*VRP PAGSRNFEETSPGAEESPGEPVPDQLPTL*WRL WG*GDFNPRLGKQSGSELFVSLQHRDFL*SQLGA GG*TGHRDDPLAS*PPGRPLLCVRQCLLACQQE APLQELWERILLQLL*PEGSSSQPAAL*TQSSM QVLL*QPTSHKLQH*P*TG*AHCCHFQLKLSDLG GQWPSCCSYDRPTQPGQTERPVHFGMGAWNHLY RVTDLGCTTGL*IDFSFLSPYSLPTFSILLLCL QKRKLSLGCLNFFFF*WKTKGCQAHCNCRAACCH VTLRDGLFLPGGRMVVRARSMEI*DREQGRKPV LTCNHSSRHRHIRAGWEPFAAGEAGSIFPKSTA LGIISLLRGAEPVPSQMDK*G*CLEGEAHGKWHP LRRLFGKGKWMLL*GRRGAGSG*PSCCPPWDPI FNLTQIVLGSFYFQGAAFLGQAV*HFPPSGMST DWSKCLCSQGQSLP*AQTHLGPHSGAWSPKQSLP QPAQGNPDSGFQKSPVPKPNQSWIFPLRGRISL *SYKPLEKGAGPIQSAFLLFSSWDRNNC*AVPL CHSWLSEWALVWLLASSEGPLGDFVGFLREVTWP *GDSGHLSSVSFDMVQKQP*IKNICGGRCGEGW RRVRFVLCNLGIHVLCLPSLLGRPCLTLLKAAN W*QGGSW*GLGVRSGNA*ALALPCIPLPLGSSSL TKGKVCLRKVVLCMPGCG*GVAQKASLVLSVQA KPRASEHVSDFQWQHSLNVVKQGVVLFHILCHL VVQVGKKLV*LKIVHFLVTGAKRL*YGFLGSDVQ CE*MLAALSSFLIDEALFY*YFPLLKEEP*LSI AVHITLFS*RGVSQCSYIFHFLSKQEVNTLELL NI*IKQIKLSVPHGSIC*HFL

Frame 2

EKAAAAAE*QPDETSQRLRRCPAPALAGSLVGW RRGRLCRGGPRHVLLPDFLVKPPSRKSSWDKLH LTSP*GKEESLVGH*RRDGDFSS*SGPLVMDEE TRHSLECIQANQIFPRKQLIREDENLQVPFLELH GESTEFVGRAEDAIIALSNYRLHIKFKESLVNV PLQLIESVECRDIFQLHLTCKDCKVIRCQFSTF EQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCME VYASEKEQHGDLCRPGEHVTSRFKNEVERMGFD MNNAWRISNINEKYKLCGSYPQELIVPAWITDK ELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQP EVSWWGWRNADDEHLVQSVAKACASDSRSSGSK LSTRNTSRDFPNGGDLSDVEFDSSLSNASGAES LAIQPQKLLILDARSYAAAVANRAKGGGCECPEY YPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPD PGNWLSALESTKWLHHLSVLLKSALLVVHAVDQ DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTI EGFQVLVEMEWLDFGHKFADRCGHGENSDDLNE RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKL VQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWS LLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLML WSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPP LSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLN EKWQEHRRSLELSSLAGPGEDPLSADSLGKPTR VPGGAELSVAAGVAEGQMENILQEATKEESGVE EPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIG LHQDPELGDAALRSHLDMSWPLFSQGISEQQSG LSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEG REEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETR GPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNS GKDRLPQTMEPSPSETSLVERPQVGSVVHRTSL GSTLSLTRSPCALPLAECKEGLVCNGAPETENRA SEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLS RQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSAT SSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGH QQEVETLKKQVQELKSRLESQYLTSSLHFNGDF GDEVTSIPDSESNLDQNCLSRCSTEIFSEASWE QVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRK HHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVC KSCYSSLHPTSSSIDLELDKPIAATSN*SSVTW VGSGQAAVPMTGPLNLGRPRGPCTLEWERGTTCT E*QIWDAPLDCRLIFLSCPPTPSLPFPSSSSAF KKGNFPLVVLIFFFFDGRPRVARPTVTAELPAV T*H*GMACFFRVGGWWSEPGVWRSETVSREESQC *HATIPHATATSELVGNPLLLGRLEAYSPRALP WASSPSCEELSQSPHRWINEADVWRERHTVNGI PLGASLGKESGCSFEAGEGLGVGSRHVVPRGIPF LT*PRLSWAPFTFRGLLSWARLCSTSHPQA*VQ TGQNVYAVKAKACPEPRHTWVPILGPGPLNNLF LSQHREIQTQGSRNPPFPNQTNHGSSL*GVESAF RVTSPWKREQVPYNQPFSSSLLGTGITAEQSPF ATPGCLSGHLSGCWPAVKGHLVTS*GSLEK*HG LEEIQGTFPQ*ALIWSKNSLKSRIFVEVGVGKVG EELGLCFVILASMFCACPPSWGGHA*LC*KLLT GDRVDHGED*G*GQGMLKLWPCPVFLFPLVAVP *PRARCVSGRWFCACLGVVKAWPRRLPWCSQSRQ SPEHLSTSLTSSGNTV*TW*NRV*FFSTFCVI* SCR*GKSWSN*RLCIS**QVPRGYDTGFLGLMY SVNKCLQLLALF*SMKHFFINIFLC*RRNRNSP* LYI*PFSPKEESVSAPIFFIFCQSKK*IL*NC* IYK*SK*S*VFHMVAFANTS*

Sequence NM_153050

GTGAGAAGGCGGCGGCGGCGGCGGAGTAGCAGCCGGACGAGACGTCCCAGCGGCTCAGGCGCTGCCCAGCGCCGGCCCTGGCAGGGAGCCTGGTGGGGTG GCGGAGGGGGAGACTGTGCCGTGGAGGGCCTCGCCATGTCCTGCTGCCCGACTTCCTTGTGAAACCTCCTAGTAGAAAAAGTTCTTGGGACAAACTTCAT TTGACTTCACCATAAGGGAAAGAAGAGAGCCTTGTTGGACACTGAAGAAGGGACGGGGATTTCTCCTCCTAATCTGGGCCTCTTGTCATGGATGAAGAGA CTCGGCACAGCCTTGAGTGCATCCAGGCCAATCAGATCTTTCCCAGGAAGCAGCTGATCCGGGAGGATGAGAATCTTCAGGTTCCTTTCCTTGAACTTCA TGGAGAGAGCACAGAGTTTGTGGGCCGTGCCGAGGATGCCATCATTGCCCTTTCCAATTACAGACTTCACATCAAGTTCAAGGAGTCTCTTGTTAATGTT CCATTACAGCTTATAGAAAGTGTTGAATGCCGAGATATATTTCAGCTTCATTTGACTTGCAAAGACTGCAAAGTTATCAGGTGTCAGTTTTCAACCTTTG AGCAGTGTCAAGAGTGGCTGAAGAGACTGAACAACGCAATCCGACCACCTGCTAAAATAGAAGATCTCTTCTCATTTGCATACCATGCTTGGTGCATGGA GGTCTATGCCAGTGAAAAAGAGCAACATGGAGACCTGTGCAGACCAGGGGAGCATGTAACTTCAAGGTTTAAAAACGAGGTGGAGAGGATGGGTTTTGAT ATGAACAACGCCTGGAGGATTTCCAACATCAATGAGAAGTACAAATTATGTGGTAGCTATCCTCAAGAGCTCATAGTGCCTGCCTGGATCACTGACAAAG AACTGGAAAGTGTATCAAGTTTCAGGTCCTGGAAGCGCATCCCTGCCGTCATCTACAGGCACCAGAGCAATGGAGCTGTCATTGCCCGCTGTGGACAGCC AGAGGTTAGCTGGTGGGGCTGGCGAAATGCAGATGATGAGCATCTGGTACAGTCAGTAGCCAAAGCTTGTGCCTCTGACTCCCGATCGAGTGGCAGCAAG CTGTCAACTAGGAACACTTCTCGAGACTTTCCCAATGGGGGAGACCTTTCTGACGTGGAGTTCGATTCTTCTCTGTCAAATGCTTCAGGAGCAGAGAGTT TAGCCATCCAACCGCAGAAGCTTTTGATCTTGGATGCACGCTCCTATGCAGCTGCTGTGGCAAACCGAGCCAAAGGAGGAGGCTGCGAATGCCCAGAGTA TTACCCAAACTGTGAAGTTGTGTTTATGGGGATGGCAAACATTCATTCTATTCGGAGGAGTTTTCAGTCTCTGCGGTTGCTGTGCACTCAGATGCCAGAT CCGGGAAATTGGCTATCAGCTCTTGAAAGCACAAAATGGCTCCATCACTTGTCTGTGCTTCTGAAATCAGCGCTTCTGGTAGTGCATGCTGTGGATCAGG ATCAGCGGCCGGTGCTAGTACACTGCTCAGATGGCTGGGACCGCACCCCCCAGATTGTGGCATTGGCTAAGCTCTTGCTGGACCCTTATTACCGAACCAT AGAGGGTTTCCAGGTCCTCGTGGAAATGGAGTGGCTGGATTTTGGCCATAAATTTGCTGACCGGTGTGGTCATGGGGAGAACTCGGATGATCTGAATGAA CGTTGCCCAGTGTTTCTGCAGTGGCTTGACTGTGTTCATCAGCTTCAGAGGCAATTTCCTTGCTCTTTTGAGTTCAATGAAGCATTCCTTGTGAAACTGG TGCAGCATACCTATTCCTGCCTGTTTGGAACATTCCTGTGCAACAACGCCAAGGAGAGAGGGGAAAAGCATACTCAGGAACGGACATGTTCCGTGTGGTC ACTTCTTCGGGCAGGCAACAAGGCTTTCAAAAACCTACTGTATTCCTCTCAGTCAGAAGCCGTGCTGTACCCTGTGTGCCATGTGCGTAACCTGATGCTG TGGAGTGCAGTGTACCTGCCCTGCCCATCCCCAACCACCCCTGTGGACGACAGCTGTGCACCATACCCAGCCCCAGGCACCAGCCCTGATGATCCCCCCC TGAGCCGGCTACCAAAGACTAGATCATACGACAATCTGACCACAGCCTGTGACAACACAGTGCCTCTGGCCAGCCGGCGCTGCAGCGACCCCAGCCTGAA CGAGAAGTGGCAGGAGCACCGGCGCTCACTAGAGCTGAGCAGCCTGGCTGGCCCTGGAGAGGATCCCCTTTCTGCCGACAGCCTAGGGAAGCCCACCAGA GTGCCGGGGGGTGCCGAGCTTTCTGTTGCAGCCGGAGTAGCTGAGGGGCAGATGGAGAACATCTTGCAGGAGGCCACCAAAGAGGAGAGTGGAGTAGAGG AACCTGCCCACAGGGCAGGCATTGAGATACAGGAGGGTAAAGAGGACCCTCTCTTAGAAAAGGAGAGCAGGAGGAAGACACCTGAGGCCTCAGCCATTGG ACTTCACCAAGACCCAGAACTGGGTGATGCTGCTCTGAGGAGCCATCTGGATATGAGCTGGCCTCTGTTCTCACAGGGCATTTCTGAACAGCAGAGTGGG CTCAGTGTTCTCCTCAGTTCTCTCCAGGTCCCCCCCAGGGGAGAGGATTCCCTGGAGGTCCCTGTGGAGCAGTTTCGAATAGAAGAGATTGCAGAGGGTA GGGAGGAAGCAGTTCTTCCAATCCCAGTAGATGCAAAAGTTGGCTATGGTACCTCACAGTCATGTTCTCTGCTACCTTCCCAAGTCCCTTTTGAGACCAG AGGACCAAACGTGGACAGTTCTACAGACATGTTAGTGGAAGATAAGGTGAAGTCAGTAAGTGGGCCCCAAGGTCATCATAGATCTTGCCTTGTAAATAGT GGCAAGGACAGGCTTCCTCAGACCATGGAACCCAGCCCTTCAGAGACAAGCCTGGTCGAGAGGCCCCAAGTGGGGTCTGTGGTGCATAGGACTTCCCTTG GCAGCACTCTCAGCCTGACACGTTCCCCTTGTGCCTTGCCTTTAGCCGAATGTAAAGAGGGGCTTGTGTGCAATGGTGCCCCAGAGACTGAAAACAGGGC CTCAGAGCAGCCCCCAGGTCTTAGCACCCTCCAGATGTACCCCACACCCAATGGGCATTGCGCCAATGGGGAGGCTGGTAGGAGCAAGGACTCACTGAGC CGTCAGCTGTCTGCTATGAGCTGCAGCTCTGCCCACTTACACTCAAGGAACTTGCACCACAAGTGGCTGCATAGCCACTCAGGAAGGCCATCTGCAACCA GCAGCCCCGACCAGCCTTCCCGCAGCCACCTGGACGATGATGGCATGTCAGTGTACACAGACACGATCCAACAGCGCCTGCGTCAGATTGAGTCAGGCCA CCAGCAGGAAGTAGAAACTTTGAAGAAACAAGTCCAGGAGCTGAAGAGTCGCCTGGAGAGCCAGTACCTGACCAGCTCCCTACACTTTAATGGAGACTTT GGGGATGAGGTGATGACCCGTTGGCTTCCTGACCACCTGGCCGCCCACTGCTATGCGTGCGACAGTGCCTTCTGGCTTGCCAGCAGGAAGCACCACTGCA GGGACACTGACCGTGTTGATCAAACGTGGAATTGTGGGAACGTATTCTGCTCCAGTTGTTGTAACCAGAAGGTTCCAGTTCCCAGCCAGCAGCTCTTTGA ACCCAGTCGAGTATGCAAGTCTTGCTATAGCAGCCTACATCCCACAAGCTCCAGCATTGACCTTGAACTGGATAAGCCCATTGCTGCCACTTCCAACTGA AGCTCAGTGACCTGGGTGGGCAGTGGCCAAGCTGCTGTTCCTATGACAGGCCCACTCAACCTGGGCAGACCGAGAGGCCCGTGCACTTTGGAATGGGAGC GTGGAACCACCTGTACAGAGTGACAGATTTGGGATGCACCACTGGATTGTAGATTGATTTTTCTTTCCTGTCCCCCTACTCCCTCCCTACCTTTTCCATC CTCCTCCTCTGCCTTCAAAAAAGGAAACTTTCCCTTGGTTGTCTTAATTTTTTTTTTTTTTGATGGAAGACCAAGGGTTGCCAGGCCCACTGTAACTGCC GAGCTGCCTGCTGTCACGTGACACTGAGGGATGGCTTGTTTCTTCCGGGTGGGAGGATGGTGGTCAGAGCCAGGAGTATGGAGATCTGAGACCGTGAGCA GGGAAGAAAGCCAGTGCTAACATGCAACCATTCCTCACGCCACCGCCACATCAGAGCTGGTTGGGAACCCTTTGCTGCTGGGGAGGCTGGAAGCATATTC CCCAAGAGCACTGCCCTGGGCATCATCTCCCTCCTGCGAGGAGCTGAGCCAGTCCCCTCACAGATGGATAAATGAGGCTGATGTTTGGAGGGAGAGGCAC ACGGTAAATGGCATCCCCTTAGGCGCCTCTTTGGGAAAGGAAAGTGGATGCTCCTTTGAGGCAGGCGAGGGGCTGGGAGTGGGTAGCCGTCATGTTGTCC CCCGTGGGATCCCATTTTTAACTTGACCCAGATTGTCTTGGGCTCCTTTTACTTTCAGGGGGCTGCTTTCCTGGGCCAGGCTGTGTAGCACTTCCCACCC TCAGGCATGAGTACAGACTGGTCAAAATGTTTATGCAGTCAAGGCCAAAGCCTGCCCTGAGCCCAGACACACCTGGGTCCCCATTCTGGGGCCTGGTCCC CTAAACAATCTCTTCCTCAGCCAGCACAGGGAAATCCAGACTCAGGGTTCCAGAAATCCCCCGTTCCCAAACCAAACCAATCATGGATCTTCCCTTTAAG GGGTAGAATCAGCCTTTAGAGTTACAAGCCCCTGGAAAAGGGAGCAGGTCCCATACAATCAGCCTTTCTCCTCTTCTCTTCTTGGGACAGGAATAACTGC TGAGCAGTCCCCCTTTGCCACTCCTGGCTGTCTGAGTGGGCACTTGTCTGGCTGCTGGCCAGCAGTGAAGGGCCACTTGGTGACTTCGTAGGGTTCCTTA GAGAAGTGACATGGCCTTGAGGAGATTCAGGGCACCTTTCCTCAGTGAGCTTTGATATGGTCCAAAAACAGCCTTAAATCAAGAATATTTGTGGAGGTAG GTGTGGGGAAGGTTGGAGAAGAGTTAGGTTTGTGCTTTGTAATCTTGGCATCCATGTTTTGTGCCTGCCCTCCCTCTTGGGGAGGCCATGCTTGACTCTG CTGAAAGCTGCTAACTGGTGACAGGGTGGATCATGGTGAGGACTAGGGGTAAGGTCAGGGAATGCTTAAGCTCTGGCCCTGCCCTGTATTCCTCTTCCCC TTGGTAGCAGTTCCCTGACCAAGGGCAAGGTGTGTCTCAGGAAGGTGGTTCTGTGCATGCCTGGGTGTGGTTAAGGCGTGGCCCAGAAGGCTTCCCTGGT GCTCTCAGTCCAGGCAAAGCCCAGAGCATCTGAGCACGTCTCTGACTTCCAGTGGCAACACAGTTTGAACGTGGTGAAACAGGGTGTAGTTCTTTTCCAC ATTCTGTGTCATCTAGTCGTGCAGGTAGGGAAAAAGTTGGTCTAATTGAAGATTGTGCATTTCCTAGTGACAGGTGCCAAGAGGTTATGATACGGGTTTC TTGGGTCTGATGTACAGTGTGAATAAATGCTTGCAGCTCTTAGCTCTTTTTTGATCGATGAAGCACTTTTTTATTAATATTTTCCTTTGTTAAAGGAGGA ACCGTAACTCTCCATAGCTGTACATATAACCCTTTTCTCCTAAAGAGGAGTCAGTCAGTGCTCCTATATTTTTCATTTTTTGTCAAAGCAAGAAGTAAAT ACTTTAGAATTGTTAAATATATAAATAAAGCAAATAAAGTTGAGTGTTCCACATGGTAGCATTTGCTAACACTTCCTAA

refseq_MTMR3.F1 (forward primer)
refseq_MTMR3.R1 (reverse primer)
Single exon skipping

Frame 0

VRRRRRRRSSSRTRRPSGSGAAQRRPWQGAWWG GGGGDCAVEGLAMSCCPTSL*NLLVEKVLGTNFI *LHHKGKKRALLDTEEGTGISPPNLGLLSWMKR LGTALSASRPIRSFPGSS*SGRMRIFRFLSLNF MERAQSLWAVPRMPSLPFPITDFTSSSRSLLLMF HYSL*KVLNAEIYFSFI*LAKTAKLSGVSFQPL SSVKSG*RD*TTQSDHLLK*KISSHLHTMLGAW RSMPVKKSNMETCADQGSM*LQGLKTRWRGWVLI *TTPGGFPTSMRSTNYVVAILKSS*CLPGSLTK NWKVYQVSGPGSASLPSSTGTRAMELSLPAVDS QRLAGGAGEMQMMSIWYSQ*PKLVPLTPDRVAAS CQLGTLLETFPMGETFLTWSSILLCQMLQEQRV *PSNRRSF*SWMHAPMQLLWQTEPKEEAANAQS ITQTVKLCLWGWQTFILFGGVFSLCGCCALRCQI REIGYQLLKAQNGSITCLCF*NQRFW*CMLWIR ISGRC*YTAQMAGTAPPRLWHWLSSCWTLITEP *RVSRSSWKWSGWILAINLLTGVVMGRTRMI*MN VAQCFCSGLTVFISFRGNFLALLSSMKHSL*NW CSIPIPACLEHSCATTPRREGKSILRNGHVPCG HFFGQATRLSKTYCIPLSQKPCCTLCAMCVT*CC GVQCTCPAHPQPPLWTTAVHHTQPQAPALMIPP *AGYQRLDHTTI*PQPVTTQCLWPAGAAATPA* TRSGRSTGAH*S*AAWLALERIPFLPTA*GSPPE CRGVPSFLLQPE*LRGRWRTSCRRPPKRRVE*R NLPTGQALRYRRVKRTLS*KRRAGGRHLRPQPL DFTKTQNWVMLL*GAIWI*AGLCSHRAFLNSRVG SVFSSVLSRSPPGERIPWRSLWSSFE*KRLQRV GRKQFFQSQ*MQKLAMVPHSHVLCYLPKSLLRP EDQTWTVLQTC*WKIR*SQ*VGPKVIIDLAL*IV ARTGFLRPWNPALQRQAWSRGPKWGLWCIGLPL AALSA*HVPLVPCL*PNVKRGLCAMVPQRLKTG PQSSPQVLAPSRCTPHPMGIAPMGRLVGARTH*A VSCLL*AAALPTYTQGTCTTSGCIATQEGHLQP AAPTSLPAATWTMMACQCTQTRSNSACVRLSQA TSRK*KL*RNKSRS*RVAWRAST*PAPYTLMETL GMR**PVGFLTTWPPTAMRATVPSGLPAGSTTA GTLTVLIKRGIVGTYSAPVVVTRRFQFPASSSL NPVEYASLAIAAYIPQAPALTLNWISPLLPLPTE AQ*PGWAVAKLLFL*QAHSTWADREARALWNGS VEPPVQSDRFGMHHWIVD*FFFPVPLLPPYLFH PPPLPSKKETFPWLS*FFFFLMEDQGLPGPL*LP SCLLSRDTEGWLVSSGWEDGGQSQEYGDLRP*A GKKASANMQPFLTPPPHQSWLGTLCCWGGWKHI PQEHCPGHHLPPARS*ASPLTDG*MRLMFGGRGT R*MASP*APLWERKVDAPLRQARGWEWVAVMLS PVGSHF*LDPDCLGLLLLSGGCFPGPGCVALPT LRHEYRLVKMFMQSRPKPALSPDTPGSPFWGLVP *TISSSASTGKSRLRVPEIPRSQTKPIMDLPFK G*NQPLELQAPGKGSRSHTISLSPLLFLGQE*L LSSPPLPLLAV*VGTCLAAGQQ*RATW*LRRVP* RSDMALRRFRAPFLSEL*YGPKTALNQEYLWR* VWGRLEKS*VCAL*SWHPCFVPALPLGEAMLDS AESC*LVTGWIMVRTRGKVRECLSSGPALYSSSP W*QFPDQGQGVSQEGGSVHAWVWLRRGPEGFPG ALSPGKAQSI*ARL*LPVATQFERGETGCSSFP HSVSSSRAGREKVGLIEDCAFPSDRCQEVMIRVS WV*CTV*INACSS*LFFDR*STFLLIFSFVKGG TVTLHSCTYNPFLLKRSQSVLLYFSFFVKARSK YFRIVKYINKANKVECSTW*HLLTLP

Frame 1

*EGGGGGGVAAGRDVPAAQALPSAGPGREPGGV AEGETVPWRASPCPAARLPCETS**KKFLGQTS FDFTIRERREPCWTLKKGRGFLLLIWASCHG*RD SAQP*VHPGQSDLSQEAADPGG*ESSGSFP*TS WREHRVCGPCRGCHHCPFQLQTSHQVQGVSC*C SITAYRKC*MPRYISASFDLQRLQSYQVSVFNL* AVSRVAEETEQRNPTTC*NRRSLLICIPCLVHG GLCQ*KRATWRPVQTRGACNFKV*KRGGEDGF* YEQRLEDFQHQ*EVQIMW*LSSRAHSACLDH*QR TGKCIKFQVLEAHPCRHLQAPEQWSCHCPLWTA RG*LVGLAKCR**ASGTVSSQSLCL*LPIEWQQ AVN*EHFSRLSQWGRPF*RGVRFFSVKCFRSREF SHPTAEAFDLGCTLLCSCCGKPSQRRRLRMPRV LPKL*SCVYGDGKHSFYSEEFSVSAVAVHSDAR SGKLAISS*KHKMAPSLVCASEISASGSACCGSG SAAGASTLLRWLGPHPPDCGIG*ALAGPLLPNH RGFPGPRGNGVAGFWP*IC*PVWSWGELG*SE* TLPSVSAVA*LCSSASEAISLLF*VQ*SIPCETG AAYLFLPVWNIPVQQRQGERGKAYSGTDMFRVV TSSGRQQGFQKPTVFLSVRSRAVPCVPCA*PDA VECSVPALPIPNHPCGRQLCTIPSPRHQP**SPP EPATKD*IIRQSDHSL*QHSASGQPALQRPQPE REVAGAPALTRAEQPGWPWRGSPFCRQPREAHQ SAGGCRAFCCSRSS*GADGEHLAGGHQRGEWSRG TCPQGRH*DTGG*RGPSLRKGEQEEDT*GLSHW TSPRPRTG*CCSEEPSGYELASVLTGHF*TAEW AQCSPQFSPGPPQGRGFPGGPCGAVSNRRDCRG* GGSSSSNPSRCKSWLWYLTVMFSATFPSPF*DQ RTKRGQFYRHVSGR*GEVSKWAPRSS*ILPCK* WQGQASSDHGTQPFRDKPGREAPSGVCGA*DFPW QHSQPDTFPLCLAFSRM*RGACVQWCPRD*KQG LRAAPRS*HPPDVPHTQWALRQWGGW*EQGLTE PSAVCYELQLCPLTLKELAPQVAA*PLRKAICNQ QPRPAFPQPPGR*WHVSVHRHDPTAPASD*VRP PAGSRNFEETSPGAEESPGEPVPDQLPTL*WRL WG*GDDPLAS*PPGRPLLCVRQCLLACQQEAPLQ GH*PC*SNVELWERILLQLL*PEGSSSQPAAL* TQSSMQVLL*QPTSHKLQH*P*TG*AHCCHFQL KLSDLGGQWPSCCSYDRPTQPGQTERPVHFGMGA WNHLYRVTDLGCTTGL*IDFSFLSPYSLPTFSI LLLCLQKRKLSLGCLNFFFF*WKTKGCQAHCNC RAACCHVTLRDGLFLPGGRMVVRARSMEI*DREQ GRKPVLTCNHSSRHRHIRAGWEPFAAGEAGSIF PKSTALGIISLLRGAEPVPSQMDK*G*CLEGEA HGKWHPLRRLFGKGKWMLL*GRRGAGSG*PSCCP PWDPIFNLTQIVLGSFYFQGAAFLGQAV*HFPP SGMSTDWSKCLCSQGQSLP*AQTHLGPHSGAWS PKQSLPQPAQGNPDSGFQKSPVPKPNQSWIFPLR GRISL*SYKPLEKGAGPIQSAFLLFSSWDRNNC *AVPLCHSWLSEWALVWLLASSEGPLGDFVGFL REVTWP*GDSGHLSSVSFDMVQKQP*IKNICGGR CGEGWRRVRFVLCNLGIHVLCLPSLLGRPCLTL LKAANW*QGGSW*GLGVRSGNA*ALALPCIPLP LGSSSLTKGKVCLRKVVLCMPGCG*GVAQKASLV LSVQAKPRASEHVSDFQWQHSLNVVKQGVVLFH ILCHLVVQVGKKLV*LKIVHFLVTGAKRL*YGF LGSDVQCE*MLAALSSFLIDEALFY*YFPLLKEE P*LSIAVHITLFS*RGVSQCSYIFHFLSKQEVN TLELLNI*IKQIKLSVPHGSIC*HFL

Frame 2

EKAAAAAE*QPDETSQRLRRCPAPALAGSLVGW RRGRLCRGGPRHVLLPDFLVKPPSRKSSWDKLH LTSP*GKEESLVGH*RRDGDFSS*SGPLVMDEE TRHSLECIQANQIFPRKQLIREDENLQVPFLELH GESTEFVGRAEDAIIALSNYRLHIKFKESLVNV PLQLIESVECRDIFQLHLTCKDCKVIRCQFSTF EQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCME VYASEKEQHGDLCRPGEHVTSRFKNEVERMGFD MNNAWRISNINEKYKLCGSYPQELIVPAWITDK ELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQP EVSWWGWRNADDEHLVQSVAKACASDSRSSGSK LSTRNTSRDFPNGGDLSDVEFDSSLSNASGAES LAIQPQKLLILDARSYAAAVANRAKGGGCECPEY YPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPD PGNWLSALESTKWLHHLSVLLKSALLVVHAVDQ DQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTI EGFQVLVEMEWLDFGHKFADRCGHGENSDDLNE RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKL VQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWS LLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLML WSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPP LSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLN EKWQEHRRSLELSSLAGPGEDPLSADSLGKPTR VPGGAELSVAAGVAEGQMENILQEATKEESGVE EPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIG LHQDPELGDAALRSHLDMSWPLFSQGISEQQSG LSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEG REEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETR GPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNS GKDRLPQTMEPSPSETSLVERPQVGSVVHRTSL GSTLSLTRSPCALPLAECKEGLVCNGAPETENRA SEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLS RQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSAT SSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGH QQEVETLKKQVQELKSRLESQYLTSSLHFNGDF GDEVMTRWLPDHLAAHCYACDSAFWLASRKHHC RDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFE PSRVCKSCYSSLHPTSSSIDLELDKPIAATSN* SSVTWVGSGQAAVPMTGPLNLGRPRGPCTLEWE RGTTCTE*QIWDAPLDCRLIFLSCPPTPSLPFPS SSSAFKKGNFPLVVLIFFFFDGRPRVARPTVTA ELPAVT*H*GMACFFRVGGWWSEPGVWRSETVS REESQC*HATIPHATATSELVGNPLLLGRLEAYS PRALPWASSPSCEELSQSPHRWINEADVWRERH TVNGIPLGASLGKESGCSFEAGEGLGVGSRHVV PRGIPFLT*PRLSWAPFTFRGLLSWARLCSTSHP QA*VQTGQNVYAVKAKACPEPRHTWVPILGPGP LNNLFLSQHREIQTQGSRNPPFPNQTNHGSSL* GVESAFRVTSPWKREQVPYNQPFSSSLLGTGITA EQSPFATPGCLSGHLSGCWPAVKGHLVTS*GSL EK*HGLEEIQGTFPQ*ALIWSKNSLKSRIFVEV GVGKVGEELGLCFVILASMFCACPPSWGGHA*LC *KLLTGDRVDHGED*G*GQGMLKLWPCPVFLFP LVAVP*PRARCVSGRWFCACLGVVKAWPRRLPW CSQSRQSPEHLSTSLTSSGNTV*TW*NRV*FFST FCVI*SCR*GKSWSN*RLCIS**QVPRGYDTGF LGLMYSVNKCLQLLALF*SMKHFFINIFLC*RR NRNSP*LYI*PFSPKEESVSAPIFFIFCQSKK*I L*NC*IYK*SK*S*VFHMVAFANTS*