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Sequences

Sequence NM_016834

CCTCCCCTGGGGAGGCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAACGCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCG CCACCCACCAGCTCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGCCACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCG TCCTCGCCTCTGTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTG GGGGACAGGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGCTGAAGAAGCAGGCATTGGAGACACCC CCAGCCTGGAAGACGAAGCTGCTGGTCACGTGACCCAAGCTCGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAAAGCCAAGGGGGC TGATGGTAAAACGAAGATCGCCACACCGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCAGCAAAAACCCCGCCCGCT CCAAAGACACCACCCAGCTCTGGTGAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCAGGCACTCCCGGCAGCCGCTCCCGCA CCCCGTCCCTTCCAACCCCACCCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGTCGCCGTCTTCCGCCAAGAGCCGCCTGCAGAC AGCCCCCGTGCCCATGCCAGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAAGCACCAGCCGGGAGGCGGGAAGGTGCAGATAATT AATAAGAAGCTGGATCTTAGCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACACGTCCCGGGAGGCGGCAGTGTGCAAATAGTCTACAAAC CAGTTGACCTGAGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGA CTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTC CGCGAGAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCT CCTCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGATCAGGCCC CTGGGGCGGTCAATAATTGTGGAGAGGAGAGAATGAGAGAGTGTGGAAAAAAAAAGAATAATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGCTCCTCGC AGTTCGGTTAATTGGTTAATCACTTAACCTGCTTTTGTCACTCGGCTTTGGCTCGGGACTTCAAAATCAGTGATGGGAGTAAGAGCAAATTTCATCTTTC CAAATTGATGGGTGGGCTAGTAATAAAATATTTAAAAAAAAACATTCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGATTCTTTTT TCTTCCCCCTCCATGTAGAAGAGGGAGAAGGAGAGGCTCTGAAAGCTGCTTCTGGGGGATTTCAAGGGACTGGGGGTGCCAACCACCTCTGGCCCTGTTG TGGGGGTGTCACAGAGGCAGTGGCAGCAACAAAGGATTTGAAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATGTCAACCTTGTGTGAGTGTGACGG GGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCGAGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTGGGAGAGGAAGCCACGTG CTGGAGAGTAGACATCCCCCTCCTTGCCGCTGGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGCCTGTCCTTGGTGGCCGGGGGTGGGG GCCTGCTGTGGGTCAGTGTGCCACCCTCTGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGCAAGCTGGCAGGAGGGTGGCACTTCG TGGATGACCTCCTTAGAAAAGACTGACCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGTAGGGGGCCTGAGTTGAGGGGCTTCCCT CTGCTCCACAGAAACCCTGTTTTATTGAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGCAGACCTGGGACTTTAGGGCTAACCAGTTC TCTTTGTAAGGACTTGTGCCTCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTGGAGTGTGTGGGGGTCTGGGAGGCAGGTCCCG AGCCCCCTGTCCTTCCCACGGCCACTGCAGTCACCCCTGTCTGCGCCGCTGTGCTGTTGTCTGCCGTGAGAGCCCAATCACTGCCTATACCCCTCATCAC ACGTCACAATGTCCCGAATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAGGAGGTACCTACTCCATACTGAGGGTGAAATTAAG GGAAGGCAAAGTCCAGGCACAAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCAACTGGGACCCTCACCACGAATCTCATGATCTGATTCG GTTCCCTGTCTCCTCCTCCCGTCACAGATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAGGTGTTTCTGCCTTGTTGACATGGAGAGAGCCCTTTCCC CTGAGAAGGCCTGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTTGTCAGTGGTGGCACCAGGATGGAAGGGCAAGGCACCCAGG GCAGGCCCACAGTCCCGCTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTCCCAGACAGCCCAGCCCGCTGCTCAGCTCCACATGCATAGTATC AGCCCTCCACACCCGACAAAGGGGAACACACCCCCTTGGAAATGGTTCTTTTCCCCCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGGAGCAGCT GAACATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGTAGTTGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTGACTATGA TAGTGAAAAGAAAAAAAAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTTGTAAAGAGGTTTCTAACCCACCCTCACGAGGTGTCTCTCACCCCCACA CTGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCTGGGGCCTCCCAAGTTTTGAAAGGCTTTCCTCAGCACCTGGGACCCAACAGAGACCAGCTTCTAG CAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGATTAGGACTGAAGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCTCCCTGTG TCAGGGCACAGACTAGGTCTTGTGGCTGGTCTGGCTTGCGGCGCGAGGATGGTTCTCTCTGGTCATAGCCCGAAGTCTCATGGCAGTCCCAAAGGAGGCT TACAACTCCTGCATCACAAGAAAAAGGAAGCCACTGCCAGCTGGGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCACCCCTCAGACTGGGTT CCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCCACCAAGGGCCCTGCGACCACAGCAGGGATTGGGATGAATTGCCTGTCCTGGATCTGCTC TAGAGGCCCAAGCTGCCTGCCTGAGGAAGGATGACTTGACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAGAGCACCTCAGCCCGCTGACCTTGCA CAAACTCCATCTGCTGCCATGAGAAAAGGGAAGCCGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCCAATTCTGCCACTTCTGG TTTGGGTACAGTTAAAGGCAACCCTGAGGGACTTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTCGTGTGCAGCTAGAGCTTTACCTGAA AGGAAGTCTCTGGGCCCAGAACTCTCCACCAAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGTTGAAGGGATCTGAGAAGGAGAAGGA AATGTGGGGTAGATTTGGTGGTGGTTAGAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTCACGCACCTCGGTTCCTCTTCCTGAA GTTCTTGTGCCCTGCTCTTCAGCACCATGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGGCAGGCTCTTGGGGCCAGCCTAAGATCA TGGTTTAGGGTGATCAGTGCTGGCAGATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCCCCCAGGGCTGGGCACTCCTCCCCTC CCCTCACTTCTCCCACCTGCAGAGCCAGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTTCAAGCTGCTGACTCACTTTATCAATAG TTCCATTTAAATTGACTTCAGTGGTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGGGGGAGGAATGTGTAAGATAGTTAACATG GGCAAAGGGAGATCTTGGGGTGCAGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTTGCTAGAGGGAGGGAGCAGCCACGGAGTTAG AGGCCCTTGGGGTTTCTCTTTTCCACTGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCCAGCCAGGTGCAGGCGTAGGAATATGGACATCT GGTTGCTTTGGCCTGCTGCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTTGGCATCCTTCCCTCTAAGCCGTTGGCACCTCTGT GCCACCTCTCACACTGGCTCCAGACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCACCCTCCTCATCTTTGTTCTCCAAGTAAAGCCACGAG GTCGGGGCGAGGGCAGAGGTGATCACCTGCGTGTCCCATCTACAGACCTGCGGCTTCATAAAACTTCTGATTTCTCTTCAGCTTTGAAAAGGGTTACCCT GGGCACTGGCCTAGAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGCAGGACTATTTCTGGCACTTGCAAGTCCCATGATTTCTT CGGTAATTCTGAGGGTGGGGGGAGGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTGAATGTCTATATAGTGTATTGTGTGTTTTAACAAATGATT TACACTGACTGTTGCTGTAAAAGTGAATTTGGAAATAAAGTTATTACTCTGATTAAA

refseq_MAPT.F5 (forward primer)
refseq_MAPT.R5 (reverse primer)
Multiple exon skipping

Frame 0

PPLGRLAFPLLAPAPPAGLRNAPSSPARALAVT ATHQLRHQQQRRCHRPPSAAATTATFSSSAVLSR PRLCRLSGEL*TRMAEPRQEFEVMEDHAGTYGL GDRKDQGGYTMHQDQEGDTDAGLKAEEAGIGDT PSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGA DGKTKIATPRGAAPPGQKGQANATRIPAKTPPA PKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSR TPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQT APVPMPDLKNVKSKIGSTENLKHQPGGGKVQII NKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYK PVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLD FKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF RENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNV SSTGSIDMVDSPQLATLADEVSASLAKQGL*SGP WGGQ*LWRGENERVWKKKE**PGPRPLPPAAPR SSVNWLIT*PAFVTRLWLGTSKSVMGVRANFIF PN*WVG***NI*KKTFKNMATSNISSGNSF*FFF LPPPCRRGRRRGSESCFWGISRDWGCQPPLALL WGCHRGSGSNKGFETWCVRGATGRRCQPCVSVT GVGVGREATGEAEAGAGQRGEEAQEVGVGEEATC WRVDIPLLAAGRAKAYATCSV*AAACPWWPGVG ACCGSVCHPLQGSLWEKGQRVKREGKLAGGWHF VDDLLRKD*P*CLESAGLFLPPCRVGGLS*GASL CSTETLFY*VLKVGTAAMILATLQTWDFRANQF SL*GLVPLGRRPPVSKPGPLASLECVGVWEAGP EPPVLPTATAVTPVCAAVLLSAVRAQSLPIPLIT RHNVPNSQPHHPFSVMTLVGCRRYLLHTEGEIK GRQSPGTRVGPQPLTLSSTHPTGTLTTNLMI*F GSLSPPPVTDVSQGTAQL*P*VFLPC*HGESPFP *EGLAPSCAEPTAAGWVSWLSVVAPGWKGKAPR AGPQSRCPPLAP*LVAANLPDSPARCSAPHA*Y QPSTPDKGEHTPLEMVLFPQSQLEAMLSVLLEQL NIYIDVALPSPSAPC*VVVGFVCLCLDSPE*L* **KEKKKKKRTHVS*NACKEVSNPPSRGVSHPH TGTRVACVVPPCWGLPSFERLSSAPGTQQRPASS S*GGRSAVTKA*STGLGLKR*CPLPYFPLGLPV SGHRLGLVAGLACGARMVLSGHSPKSHGSPKGG LQLLHHKKKEATASWGDLQLPEAP*ASATPQTGF LSKLALWRGSAASHQGPCDHSRDWDELPVLDLL *RPKLPA*GRMT*QVRRHCSQSLDQSTSAR*PC TNSICCHEKREAAFAKHCCLKKLSSLRPNSATSG LGTVKGNPEGLGSRNPGPPLGLAASCAARALPE RKSLGPELSTKSLPAVR*VPAILLS*RDLRRRR KCGVDLVVVRDMPPSLLPTVSAAFLHAPRFLFLK FLCPALQHHGPSYTEGSGISPLWGQALGASLRS WFRVISAGR*IEKARWLVILNEDNPPRAGHSSP PLTSPTCRASVLGWAR*DILYAGSFKLLTHFINS SI*IDFSGETVSCLLLLVVLWGEGGGMCKIVNM GKGRSWGAALKLPRNPFHDFNHIC*REGAATEL EALGVSLFH*QAFPGSWLVHSLPSQVQA*EYGHL VALACCPLSGVLSPQSCLPKTLASFPLSRWHLC ATSHTGSRHTACAFGAEITRFTLLIFVLQVKPR GRGEGRGDHLRVPSTDLRLHKTSDFSSALKRVTL GTGLEPHLLIDLAP*VCHVEQDYFWHLQVP*FL R*F*GWGEGHEIILA*LSVCECLYSVLCVLTND LH*LLL*K*IWK*SYYSD*

Frame 1

LPWGGSRSRCSRLRRPPASGTRPLRRRAPSQSP PPTSSGTNSSAAATAHLLPPPPQPPSPPPLSSP VLASVDYQVNFEPGWLSPARSSK*WKITLGRTGW GTGKIRGATPCTKTKRVTRTLA*KLKKQALETP PAWKTKLLVT*PKLAWSVKAKTGLEAMTKKPRG LMVKRRSPHRGEQPLQARRARPTPPGFQQKPRPL QRHHPALVNLQNQGIAAATAAPAPQALPAAAPA PRPFQPHPPGSPRRWQWSVLHPSRRLPPRAACR QPPCPCQT*RMSSPRSAPLRT*STSREAGRCR*L IRSWILATSSPSVAQRIISNTSREAAVCK*STN QLT*AR*PPSVAH*ATSIINQEVARWK*NLRSL TSRTESSRRLGPWTISPTSLAEEIKRLKPTS*PS ARTPKPRQTTGRRSCTSRQWCLGTRLHGISAMS PPPAASTW*TRPSSPR*LTRCLPPWPSRVCDQA PGAVNNCGEERMRECGKKKNNDPAPALCPQLLLA VRLIG*SLNLLLSLGFGSGLQNQ*WE*EQISSF QIDGWASNKIFKKKHSKTWPHPTFPQAIPFDSF FFPLHVEEGEGEALKAASGGFQGTGGANHLWPCC GGVTEAVAATKDLKLGVFVEPQADDVNLV*V*R GLGWGGRPRGRPRQGLGRGERKHKKWEWERKPR AGE*TSPSLPLGEPRPMPPAASERPPVLGGRGWG PAVGQCATLCRAACGRRDSG*KEKASWQEGGTS WMTSLEKTDLDVLRALASSSLPAG*GA*VEGLP SAPQKPCFIEF*RLELLP*FWPLCRPGTLGLTSS LCKDLCLLGDVHPFPSLGHWHLWSVWGSGRQVP SPLSFPRPLQSPLSAPLCCCLP*EPNHCLYPSS HVTMSRIPSLTTPSQ**PWLVAGGTYSILRVKLR EGKVQAQEWDPSLSLSVPLIQLGPSPRIS*SDS VPCLLLPSQM*ARALLSCDPRCFCLVDMERALS PEKAWPLPVLSPQQQAGCLGCQWWHQDGRARHPG QAHSPAVPHLHPSL*LPTSQTAQPAAQLHMHSI SPPHPTKGNTPPWKWFFSPSPSWKPCCLFCWSS *TYT*MLPCPPHLHPVEL*LDLSVYAWIHQSDYD SEKKKKKKKGRMYLEMLVKRFLTHPHEVSLTPT LGLVWPVWCHPAGASQVLKGFPQHLGPNRDQLL AAKEAVQL*RRPEAQD*D*SDDVPFPTSPWGSLC QGTD*VLWLVWLAARGWFSLVIARSLMAVPKEA YNSCITRKRKPLPAGGICSSQKLREPQPPLRLG SSPSSPSGGAAQPPTKGPATTAGIGMNCLSWICS RGPSCLPEEG*LDKSGDTVPKALTRAPQPADLA QTPSAAMRKGKPPLQNIAA*RNSAASGPILPLL VWVQLKATLRDLAVEIQGLPWGWQLRVQLELYLK GSLWAQNSPPRASLPFAESQQFS*VEGI*EGEG NVG*IWWWLEICPPHYCQQFRLHFFTHLGSSS* SSCALLFSTMGLLIRKALGSPPCGGRLLGPA*DH GLG*SVLADKLKRHAGL*S*MRTIPPGLGTPPL PSLLPPAEPVSLGGLDRIYCMPAPSSC*LTLSI VPFKLTSVVRLYPVCYCLLCYGGRGEECVR*LTW AKGDLGVQHLNCLVTLFMISTTFARGREQPRS* RPLGFLFSTDRLSQAAG*FIPSPARCRRRNMDI WLLWPAALFQGS*AHNHASLRPWHPSL*AVGTSV PPLTLAPDTQPVLLELRSLASPSSSLFSK*SHE VGARAEVITCVSHLQTCGFIKLLISLQL*KGLP WALA*SLTS**T*PHEFAMLSRTISGTCKSHDFF GNSEGGGRDMKSS*LSFLSVNVYIVYCVF*QMI YTDCCCKSEFGNKVITLIK

Frame 2

SPGEARVPAARACAARRPQERALFAGARPRSHR HPPAPAPTAAPLPPPTFCRRHHSHLLLLRCPLP SSPLSTIR*TLNQDG*APPGVRSDGRSRWDVRV GGQERSGGLHHAPRPRG*HGRWPES*RSRHWRHP QPGRRSCWSRDPSSHGQ*KQRRDWKR*QKSQGG *W*NEDRHTAGSSPSRPEGPGQRHQDSSKNPAR SKDTTQLW*TSKIRGSQRLQQPRLPRHSRQPLPH PVPSNPTHPGAQEGGSGPYSTQVAVFRQEPPAD SPRAHARPEECQVQDRLH*EPEAPAGRREGADN **EAGS*QRPVQVWLKG*YQTRPGRRQCANSLQT S*PEQGDLQVWLIRQHPS*TRRWPGGSKI*EA* LQGQSPVEDWVPGQYHPRPWRRK*KD*NPQADL PRERQSQDRPRGGDRVQVASGVWGHVSTASQQCL LHRQHRHGRLAPARHAS*RGVCLPGQAGFVIRP LGRSIIVERRE*ESVEKKRIMTRPPPSAPSCSS QFG*LVNHLTCFCHSALARDFKISDGSKSKFHLS KLMGGLVIKYLKKNIQKHGHIQHFLRQFLLILF SSPSM*KREKERL*KLLLGDFKGLGVPTTSGPV VGVSQRQWQQQRI*NLVCSWSHRQTMSTLCECDG GWGGAGGHGGGRGRGWAEGRGSTRSGSGRGSHV LESRHPPPCRWESQGLCHLQRLSGRLSLVAGGG GLLWVSVPPSAGQPVGEGTAGKKRRQAGRRVALR G*PP*KRLTLMS*ERWPLPPSLQGRGPELRGFP LLHRNPVLLSSEGWNCCHDFGHFADLGL*G*PV LFVRTCASWETSTRFQAWATGISGVCGGLGGRSR APCPSHGHCSHPCLRRCAVVCRESPITAYTPHH TSQCPEFPASPPLLSNDPGWLQEVPTPY*G*N* GKAKSRHKSGTPASHSQFHSSNWDPHHESHDLIR FPVSSSRHRCEPGHCSAVTLGVSALLTWREPFP LRRPGPFLC*AHSSRLGVLVVSGGTRMEGQGTQ GRPTVPLSPTCTLACSCQPPRQPSPLLSSTCIVS ALHTRQRGTHPLGNGSFPPVPAGSHAVCSAGAA EHIHRCCPALPICTLLSCSWICLFMLGFTRVTM IVKRKKKKKKDACILKCL*RGF*PTLTRCLSPPH WDSCGLCGATLLGPPKF*KAFLSTWDPTETSF* QLRRPFSCDEGLKHRIRTEAMMSPSLLPLGAPC VRAQTRSCGWSGLRREDGSLWS*PEVSWQSQRRL TTPASQEKGSHCQLGGSAAPRSSVSLSHPSDWV PLQARPLEGQRSLPPRALRPQQGLG*IACPGSA LEAQAACLRKDDLTSQETLFPKP*PEHLSPLTLH KLHLLP*EKGSRLCKTLLPKETQQPQAQFCHFW FGYS*RQP*GTWQ*KSRASPGAGSFVCS*SFT* KEVSGPRTLHQEPPCRSLSPSNSPKLKGSEKEKE MWGRFGGG*RYAPLITANSFGCISSRTSVPLPE VLVPCSSAPWAFLYGRLWDLPLVGAGSWGQPKI MV*GDQCWQIN*KGTLACDLK*GQSPQGWALLPS PHFSHLQSQCPWVG*IGYTVCRLLQAADSLYQ* FHLN*LQW*DCILFAIACCAMGGGGRNV*DS*H GQREILGCST*TAS*PFS*FQPHLLEGGSSHGVR GPWGFSFPLTGFPRQLASSFPPQPGAGVGIWTS GCFGLLPSFRGPKPTIMPP*DLGILPSKPLAPL CHLSHWLQTHSLCFWS*DHSLHPPHLCSPSKATR SGRGQR*SPACPIYRPAAS*NF*FLFSFEKGYP GHWPRASPPNRLSPMSLPC*AGLFLALASPMIS SVILRVGGGT*NHLSLAFCL*MSI*CIVCFNK*F TLTVAVKVNLEIKLLL*L

Sequence NM_016841

CCTCCCCTGGGGAGGCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAACGCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCG CCACCCACCAGCTCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGCCACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCG TCCTCGCCTCTGTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTG GGGGACAGGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGCTGAAGAAGCAGGCATTGGAGACACCC CCAGCCTGGAAGACGAAGCTGCTGGTCACGTGACCCAAGCTCGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAAAGCCAAGGGGGC TGATGGTAAAACGAAGATCGCCACACCGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCAGCAAAAACCCCGCCCGCT CCAAAGACACCACCCAGCTCTGGTGAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCAGGCACTCCCGGCAGCCGCTCCCGCA CCCCGTCCCTTCCAACCCCACCCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGTCGCCGTCTTCCGCCAAGAGCCGCCTGCAGAC AGCCCCCGTGCCCATGCCAGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAAGCACCAGCCGGGAGGCGGGAAGGTGCAAATAGTC TACAAACCAGTTGACCTGAGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGA AGCTTGACTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCT GACCTTCCGCGAGAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGC AATGTCTCCTCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGAT CAGGCCCCTGGGGCGGTCAATAATTGTGGAGAGGAGAGAATGAGAGAGTGTGGAAAAAAAAAGAATAATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGC TCCTCGCAGTTCGGTTAATTGGTTAATCACTTAACCTGCTTTTGTCACTCGGCTTTGGCTCGGGACTTCAAAATCAGTGATGGGAGTAAGAGCAAATTTC ATCTTTCCAAATTGATGGGTGGGCTAGTAATAAAATATTTAAAAAAAAACATTCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGAT TCTTTTTTCTTCCCCCTCCATGTAGAAGAGGGAGAAGGAGAGGCTCTGAAAGCTGCTTCTGGGGGATTTCAAGGGACTGGGGGTGCCAACCACCTCTGGC CCTGTTGTGGGGGTGTCACAGAGGCAGTGGCAGCAACAAAGGATTTGAAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATGTCAACCTTGTGTGAGT GTGACGGGGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCGAGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTGGGAGAGGAAG CCACGTGCTGGAGAGTAGACATCCCCCTCCTTGCCGCTGGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGCCTGTCCTTGGTGGCCGGG GGTGGGGGCCTGCTGTGGGTCAGTGTGCCACCCTCTGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGCAAGCTGGCAGGAGGGTGG CACTTCGTGGATGACCTCCTTAGAAAAGACTGACCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGTAGGGGGCCTGAGTTGAGGGG CTTCCCTCTGCTCCACAGAAACCCTGTTTTATTGAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGCAGACCTGGGACTTTAGGGCTAA CCAGTTCTCTTTGTAAGGACTTGTGCCTCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTGGAGTGTGTGGGGGTCTGGGAGGCA GGTCCCGAGCCCCCTGTCCTTCCCACGGCCACTGCAGTCACCCCTGTCTGCGCCGCTGTGCTGTTGTCTGCCGTGAGAGCCCAATCACTGCCTATACCCC TCATCACACGTCACAATGTCCCGAATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAGGAGGTACCTACTCCATACTGAGGGTGA AATTAAGGGAAGGCAAAGTCCAGGCACAAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCAACTGGGACCCTCACCACGAATCTCATGATC TGATTCGGTTCCCTGTCTCCTCCTCCCGTCACAGATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAGGTGTTTCTGCCTTGTTGACATGGAGAGAGCC CTTTCCCCTGAGAAGGCCTGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTTGTCAGTGGTGGCACCAGGATGGAAGGGCAAGGC ACCCAGGGCAGGCCCACAGTCCCGCTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTCCCAGACAGCCCAGCCCGCTGCTCAGCTCCACATGCA TAGTATCAGCCCTCCACACCCGACAAAGGGGAACACACCCCCTTGGAAATGGTTCTTTTCCCCCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGG AGCAGCTGAACATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGTAGTTGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTG ACTATGATAGTGAAAAGAAAAAAAAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTTGTAAAGAGGTTTCTAACCCACCCTCACGAGGTGTCTCTCAC CCCCACACTGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCTGGGGCCTCCCAAGTTTTGAAAGGCTTTCCTCAGCACCTGGGACCCAACAGAGACCAG CTTCTAGCAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGATTAGGACTGAAGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCT CCCTGTGTCAGGGCACAGACTAGGTCTTGTGGCTGGTCTGGCTTGCGGCGCGAGGATGGTTCTCTCTGGTCATAGCCCGAAGTCTCATGGCAGTCCCAAA GGAGGCTTACAACTCCTGCATCACAAGAAAAAGGAAGCCACTGCCAGCTGGGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCACCCCTCAGA CTGGGTTCCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCCACCAAGGGCCCTGCGACCACAGCAGGGATTGGGATGAATTGCCTGTCCTGGA TCTGCTCTAGAGGCCCAAGCTGCCTGCCTGAGGAAGGATGACTTGACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAGAGCACCTCAGCCCGCTGA CCTTGCACAAACTCCATCTGCTGCCATGAGAAAAGGGAAGCCGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCCAATTCTGCCA CTTCTGGTTTGGGTACAGTTAAAGGCAACCCTGAGGGACTTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTCGTGTGCAGCTAGAGCTTT ACCTGAAAGGAAGTCTCTGGGCCCAGAACTCTCCACCAAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGTTGAAGGGATCTGAGAAGG AGAAGGAAATGTGGGGTAGATTTGGTGGTGGTTAGAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTCACGCACCTCGGTTCCTCT TCCTGAAGTTCTTGTGCCCTGCTCTTCAGCACCATGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGGCAGGCTCTTGGGGCCAGCCT AAGATCATGGTTTAGGGTGATCAGTGCTGGCAGATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCCCCCAGGGCTGGGCACTCC TCCCCTCCCCTCACTTCTCCCACCTGCAGAGCCAGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTTCAAGCTGCTGACTCACTTTA TCAATAGTTCCATTTAAATTGACTTCAGTGGTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGGGGGAGGAATGTGTAAGATAGT TAACATGGGCAAAGGGAGATCTTGGGGTGCAGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTTGCTAGAGGGAGGGAGCAGCCACG GAGTTAGAGGCCCTTGGGGTTTCTCTTTTCCACTGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCCAGCCAGGTGCAGGCGTAGGAATATG GACATCTGGTTGCTTTGGCCTGCTGCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTTGGCATCCTTCCCTCTAAGCCGTTGGCA CCTCTGTGCCACCTCTCACACTGGCTCCAGACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCACCCTCCTCATCTTTGTTCTCCAAGTAAAG CCACGAGGTCGGGGCGAGGGCAGAGGTGATCACCTGCGTGTCCCATCTACAGACCTGCGGCTTCATAAAACTTCTGATTTCTCTTCAGCTTTGAAAAGGG TTACCCTGGGCACTGGCCTAGAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGCAGGACTATTTCTGGCACTTGCAAGTCCCATG ATTTCTTCGGTAATTCTGAGGGTGGGGGGAGGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTGAATGTCTATATAGTGTATTGTGTGTTTTAACA AATGATTTACACTGACTGTTGCTGTAAAAGTGAATTTGGAAATAAAGTTATTACTCTGATTAAA

refseq_MAPT.F5 (forward primer)
refseq_MAPT.R5 (reverse primer)
Multiple exon skipping

Frame 0

PPLGRLAFPLLAPAPPAGLRNAPSSPARALAVT ATHQLRHQQQRRCHRPPSAAATTATFSSSAVLSR PRLCRLSGEL*TRMAEPRQEFEVMEDHAGTYGL GDRKDQGGYTMHQDQEGDTDAGLKAEEAGIGDT PSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGA DGKTKIATPRGAAPPGQKGQANATRIPAKTPPA PKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSR TPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQT APVPMPDLKNVKSKIGSTENLKHQPGGGKVQIV YKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSE KLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKL TFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLS NVSSTGSIDMVDSPQLATLADEVSASLAKQGL* SGPWGGQ*LWRGENERVWKKKE**PGPRPLPPAA PRSSVNWLIT*PAFVTRLWLGTSKSVMGVRANF IFPN*WVG***NI*KKTFKNMATSNISSGNSF* FFFLPPPCRRGRRRGSESCFWGISRDWGCQPPLA LLWGCHRGSGSNKGFETWCVRGATGRRCQPCVS VTGVGVGREATGEAEAGAGQRGEEAQEVGVGEE ATCWRVDIPLLAAGRAKAYATCSV*AAACPWWPG VGACCGSVCHPLQGSLWEKGQRVKREGKLAGGW HFVDDLLRKD*P*CLESAGLFLPPCRVGGLS*G ASLCSTETLFY*VLKVGTAAMILATLQTWDFRAN QFSL*GLVPLGRRPPVSKPGPLASLECVGVWEA GPEPPVLPTATAVTPVCAAVLLSAVRAQSLPIP LITRHNVPNSQPHHPFSVMTLVGCRRYLLHTEGE IKGRQSPGTRVGPQPLTLSSTHPTGTLTTNLMI *FGSLSPPPVTDVSQGTAQL*P*VFLPC*HGES PFP*EGLAPSCAEPTAAGWVSWLSVVAPGWKGKA PRAGPQSRCPPLAP*LVAANLPDSPARCSAPHA *YQPSTPDKGEHTPLEMVLFPQSQLEAMLSVLL EQLNIYIDVALPSPSAPC*VVVGFVCLCLDSPE* L***KEKKKKKRTHVS*NACKEVSNPPSRGVSH PHTGTRVACVVPPCWGLPSFERLSSAPGTQQRP ASSS*GGRSAVTKA*STGLGLKR*CPLPYFPLGL PVSGHRLGLVAGLACGARMVLSGHSPKSHGSPK GGLQLLHHKKKEATASWGDLQLPEAP*ASATPQ TGFLSKLALWRGSAASHQGPCDHSRDWDELPVLD LL*RPKLPA*GRMT*QVRRHCSQSLDQSTSAR* PCTNSICCHEKREAAFAKHCCLKKLSSLRPNSA TSGLGTVKGNPEGLGSRNPGPPLGLAASCAARAL PERKSLGPELSTKSLPAVR*VPAILLS*RDLRR RRKCGVDLVVVRDMPPSLLPTVSAAFLHAPRFL FLKFLCPALQHHGPSYTEGSGISPLWGQALGASL RSWFRVISAGR*IEKARWLVILNEDNPPRAGHS SPPLTSPTCRASVLGWAR*DILYAGSFKLLTHF INSSI*IDFSGETVSCLLLLVVLWGEGGGMCKIV NMGKGRSWGAALKLPRNPFHDFNHIC*REGAAT ELEALGVSLFH*QAFPGSWLVHSLPSQVQA*EY GHLVALACCPLSGVLSPQSCLPKTLASFPLSRWH LCATSHTGSRHTACAFGAEITRFTLLIFVLQVK PRGRGEGRGDHLRVPSTDLRLHKTSDFSSALKR VTLGTGLEPHLLIDLAP*VCHVEQDYFWHLQVP* FLR*F*GWGEGHEIILA*LSVCECLYSVLCVLT NDLH*LLL*K*IWK*SYYSD*

Frame 1

LPWGGSRSRCSRLRRPPASGTRPLRRRAPSQSP PPTSSGTNSSAAATAHLLPPPPQPPSPPPLSSP VLASVDYQVNFEPGWLSPARSSK*WKITLGRTGW GTGKIRGATPCTKTKRVTRTLA*KLKKQALETP PAWKTKLLVT*PKLAWSVKAKTGLEAMTKKPRG LMVKRRSPHRGEQPLQARRARPTPPGFQQKPRPL QRHHPALVNLQNQGIAAATAAPAPQALPAAAPA PRPFQPHPPGSPRRWQWSVLHPSRRLPPRAACR QPPCPCQT*RMSSPRSAPLRT*STSREAGRCK*S TNQLT*AR*PPSVAH*ATSIINQEVARWK*NLR SLTSRTESSRRLGPWTISPTSLAEEIKRLKPTS *PSARTPKPRQTTGRRSCTSRQWCLGTRLHGISA MSPPPAASTW*TRPSSPR*LTRCLPPWPSRVCD QAPGAVNNCGEERMRECGKKKNNDPAPALCPQL LLAVRLIG*SLNLLLSLGFGSGLQNQ*WE*EQIS SFQIDGWASNKIFKKKHSKTWPHPTFPQAIPFD SFFFPLHVEEGEGEALKAASGGFQGTGGANHLW PCCGGVTEAVAATKDLKLGVFVEPQADDVNLV*V *RGLGWGGRPRGRPRQGLGRGERKHKKWEWERK PRAGE*TSPSLPLGEPRPMPPAASERPPVLGGR GWGPAVGQCATLCRAACGRRDSG*KEKASWQEGG TSWMTSLEKTDLDVLRALASSSLPAG*GA*VEG LPSAPQKPCFIEF*RLELLP*FWPLCRPGTLGL TSSLCKDLCLLGDVHPFPSLGHWHLWSVWGSGRQ VPSPLSFPRPLQSPLSAPLCCCLP*EPNHCLYP SSHVTMSRIPSLTTPSQ**PWLVAGGTYSILRV KLREGKVQAQEWDPSLSLSVPLIQLGPSPRIS*S DSVPCLLLPSQM*ARALLSCDPRCFCLVDMERA LSPEKAWPLPVLSPQQQAGCLGCQWWHQDGRAR HPGQAHSPAVPHLHPSL*LPTSQTAQPAAQLHMH SISPPHPTKGNTPPWKWFFSPSPSWKPCCLFCW SS*TYT*MLPCPPHLHPVEL*LDLSVYAWIHQS DYDSEKKKKKKKGRMYLEMLVKRFLTHPHEVSLT PTLGLVWPVWCHPAGASQVLKGFPQHLGPNRDQ LLAAKEAVQL*RRPEAQD*D*SDDVPFPTSPWG SLCQGTD*VLWLVWLAARGWFSLVIARSLMAVPK EAYNSCITRKRKPLPAGGICSSQKLREPQPPLR LGSSPSSPSGGAAQPPTKGPATTAGIGMNCLSW ICSRGPSCLPEEG*LDKSGDTVPKALTRAPQPAD LAQTPSAAMRKGKPPLQNIAA*RNSAASGPILP LLVWVQLKATLRDLAVEIQGLPWGWQLRVQLEL YLKGSLWAQNSPPRASLPFAESQQFS*VEGI*EG EGNVG*IWWWLEICPPHYCQQFRLHFFTHLGSS S*SSCALLFSTMGLLIRKALGSPPCGGRLLGPA *DHGLG*SVLADKLKRHAGL*S*MRTIPPGLGTP PLPSLLPPAEPVSLGGLDRIYCMPAPSSC*LTL SIVPFKLTSVVRLYPVCYCLLCYGGRGEECVR* LTWAKGDLGVQHLNCLVTLFMISTTFARGREQPR S*RPLGFLFSTDRLSQAAG*FIPSPARCRRRNM DIWLLWPAALFQGS*AHNHASLRPWHPSL*AVG TSVPPLTLAPDTQPVLLELRSLASPSSSLFSK*S HEVGARAEVITCVSHLQTCGFIKLLISLQL*KG LPWALA*SLTS**T*PHEFAMLSRTISGTCKSH DFFGNSEGGGRDMKSS*LSFLSVNVYIVYCVF*Q MIYTDCCCKSEFGNKVITLIK

Frame 2

SPGEARVPAARACAARRPQERALFAGARPRSHR HPPAPAPTAAPLPPPTFCRRHHSHLLLLRCPLP SSPLSTIR*TLNQDG*APPGVRSDGRSRWDVRV GGQERSGGLHHAPRPRG*HGRWPES*RSRHWRHP QPGRRSCWSRDPSSHGQ*KQRRDWKR*QKSQGG *W*NEDRHTAGSSPSRPEGPGQRHQDSSKNPAR SKDTTQLW*TSKIRGSQRLQQPRLPRHSRQPLPH PVPSNPTHPGAQEGGSGPYSTQVAVFRQEPPAD SPRAHARPEECQVQDRLH*EPEAPAGRREGANS LQTS*PEQGDLQVWLIRQHPS*TRRWPGGSKI*E A*LQGQSPVEDWVPGQYHPRPWRRK*KD*NPQA DLPRERQSQDRPRGGDRVQVASGVWGHVSTASQ QCLLHRQHRHGRLAPARHAS*RGVCLPGQAGFVI RPLGRSIIVERRE*ESVEKKRIMTRPPPSAPSC SSQFG*LVNHLTCFCHSALARDFKISDGSKSKF HLSKLMGGLVIKYLKKNIQKHGHIQHFLRQFLLI LFSSPSM*KREKERL*KLLLGDFKGLGVPTTSG PVVGVSQRQWQQQRI*NLVCSWSHRQTMSTLCE CDGGWGGAGGHGGGRGRGWAEGRGSTRSGSGRGS HVLESRHPPPCRWESQGLCHLQRLSGRLSLVAG GGGLLWVSVPPSAGQPVGEGTAGKKRRQAGRRV ALRG*PP*KRLTLMS*ERWPLPPSLQGRGPELRG FPLLHRNPVLLSSEGWNCCHDFGHFADLGL*G* PVLFVRTCASWETSTRFQAWATGISGVCGGLGG RSRAPCPSHGHCSHPCLRRCAVVCRESPITAYTP HHTSQCPEFPASPPLLSNDPGWLQEVPTPY*G* N*GKAKSRHKSGTPASHSQFHSSNWDPHHESHD LIRFPVSSSRHRCEPGHCSAVTLGVSALLTWREP FPLRRPGPFLC*AHSSRLGVLVVSGGTRMEGQG TQGRPTVPLSPTCTLACSCQPPRQPSPLLSSTC IVSALHTRQRGTHPLGNGSFPPVPAGSHAVCSAG AAEHIHRCCPALPICTLLSCSWICLFMLGFTRV TMIVKRKKKKKKDACILKCL*RGF*PTLTRCLS PPHWDSCGLCGATLLGPPKF*KAFLSTWDPTETS F*QLRRPFSCDEGLKHRIRTEAMMSPSLLPLGA PCVRAQTRSCGWSGLRREDGSLWS*PEVSWQSQ RRLTTPASQEKGSHCQLGGSAAPRSSVSLSHPSD WVPLQARPLEGQRSLPPRALRPQQGLG*IACPG SALEAQAACLRKDDLTSQETLFPKP*PEHLSPL TLHKLHLLP*EKGSRLCKTLLPKETQQPQAQFCH FWFGYS*RQP*GTWQ*KSRASPGAGSFVCS*SF T*KEVSGPRTLHQEPPCRSLSPSNSPKLKGSEK EKEMWGRFGGG*RYAPLITANSFGCISSRTSVPL PEVLVPCSSAPWAFLYGRLWDLPLVGAGSWGQP KIMV*GDQCWQIN*KGTLACDLK*GQSPQGWAL LPSPHFSHLQSQCPWVG*IGYTVCRLLQAADSLY Q*FHLN*LQW*DCILFAIACCAMGGGGRNV*DS *HGQREILGCST*TAS*PFS*FQPHLLEGGSSH GVRGPWGFSFPLTGFPRQLASSFPPQPGAGVGIW TSGCFGLLPSFRGPKPTIMPP*DLGILPSKPLA PLCHLSHWLQTHSLCFWS*DHSLHPPHLCSPSK ATRSGRGQR*SPACPIYRPAAS*NF*FLFSFEKG YPGHWPRASPPNRLSPMSLPC*AGLFLALASPM ISSVILRVGGGT*NHLSLAFCL*MSI*CIVCFN K*FTLTVAVKVNLEIKLLL*L

Sequence NM_005910

CCTCCCCTGGGGAGGCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAACGCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCG CCACCCACCAGCTCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGCCACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCG TCCTCGCCTCTGTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTG GGGGACAGGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGAATCTCCCCTGCAGACCCCCACTGAGG ACGGATCTGAGGAACCGGGCTCTGAAACCTCTGATGCTAAGAGCACTCCAACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCGGCAA GCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACAGCTGAAGAAGCAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCTGCTGGT CACGTGACCCAAGCTCGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAAAGCCAAGGGGGCTGATGGTAAAACGAAGATCGCCACAC CGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCAGCAAAAACCCCGCCCGCTCCAAAGACACCACCCAGCTCTGGTGA ACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCAGGCACTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCACCCACC CGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGTCGCCGTCTTCCGCCAAGAGCCGCCTGCAGACAGCCCCCGTGCCCATGCCAGACCTGA AGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAAGCACCAGCCGGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGATCTTAGCAACGT CCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACACGTCCCGGGAGGCGGCAGTGTGCAAATAGTCTACAAACCAGTTGACCTGAGCAAGGTGACCTCC AAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGACTTCAAGGACAGAGTCCAGTCGAAGA TTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGAGAACGCCAAAGCCAAGACAGA CCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCTCCTCCACCGGCAGCATCGACATGGTA GACTCGCCCCAGCTCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGATCAGGCCCCTGGGGCGGTCAATAATTGTGGAGAG GAGAGAATGAGAGAGTGTGGAAAAAAAAAGAATAATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGCTCCTCGCAGTTCGGTTAATTGGTTAATCACTTA ACCTGCTTTTGTCACTCGGCTTTGGCTCGGGACTTCAAAATCAGTGATGGGAGTAAGAGCAAATTTCATCTTTCCAAATTGATGGGTGGGCTAGTAATAA AATATTTAAAAAAAAACATTCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGATTCTTTTTTCTTCCCCCTCCATGTAGAAGAGGGA GAAGGAGAGGCTCTGAAAGCTGCTTCTGGGGGATTTCAAGGGACTGGGGGTGCCAACCACCTCTGGCCCTGTTGTGGGGGTGTCACAGAGGCAGTGGCAG CAACAAAGGATTTGAAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATGTCAACCTTGTGTGAGTGTGACGGGGGTTGGGGTGGGGCGGGAGGCCACG GGGGAGGCCGAGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTGGGAGAGGAAGCCACGTGCTGGAGAGTAGACATCCCCCTCCTTG CCGCTGGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGCCTGTCCTTGGTGGCCGGGGGTGGGGGCCTGCTGTGGGTCAGTGTGCCACCC TCTGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGCAAGCTGGCAGGAGGGTGGCACTTCGTGGATGACCTCCTTAGAAAAGACTGA CCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGTAGGGGGCCTGAGTTGAGGGGCTTCCCTCTGCTCCACAGAAACCCTGTTTTATT GAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGCAGACCTGGGACTTTAGGGCTAACCAGTTCTCTTTGTAAGGACTTGTGCCTCTTGG GAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTGGAGTGTGTGGGGGTCTGGGAGGCAGGTCCCGAGCCCCCTGTCCTTCCCACGGCCACT GCAGTCACCCCTGTCTGCGCCGCTGTGCTGTTGTCTGCCGTGAGAGCCCAATCACTGCCTATACCCCTCATCACACGTCACAATGTCCCGAATTCCCAGC CTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAGGAGGTACCTACTCCATACTGAGGGTGAAATTAAGGGAAGGCAAAGTCCAGGCACAAGAGT GGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCAACTGGGACCCTCACCACGAATCTCATGATCTGATTCGGTTCCCTGTCTCCTCCTCCCGTCACA GATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAGGTGTTTCTGCCTTGTTGACATGGAGAGAGCCCTTTCCCCTGAGAAGGCCTGGCCCCTTCCTGTG CTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTTGTCAGTGGTGGCACCAGGATGGAAGGGCAAGGCACCCAGGGCAGGCCCACAGTCCCGCTGTCCCCC ACTTGCACCCTAGCTTGTAGCTGCCAACCTCCCAGACAGCCCAGCCCGCTGCTCAGCTCCACATGCATAGTATCAGCCCTCCACACCCGACAAAGGGGAA CACACCCCCTTGGAAATGGTTCTTTTCCCCCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGGAGCAGCTGAACATATACATAGATGTTGCCCTGC CCTCCCCATCTGCACCCTGTTGAGTTGTAGTTGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTGACTATGATAGTGAAAAGAAAAAAAAAAAAAAAA AAGGACGCATGTATCTTGAAATGCTTGTAAAGAGGTTTCTAACCCACCCTCACGAGGTGTCTCTCACCCCCACACTGGGACTCGTGTGGCCTGTGTGGTG CCACCCTGCTGGGGCCTCCCAAGTTTTGAAAGGCTTTCCTCAGCACCTGGGACCCAACAGAGACCAGCTTCTAGCAGCTAAGGAGGCCGTTCAGCTGTGA CGAAGGCCTGAAGCACAGGATTAGGACTGAAGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCTCCCTGTGTCAGGGCACAGACTAGGTCTTGTGGC TGGTCTGGCTTGCGGCGCGAGGATGGTTCTCTCTGGTCATAGCCCGAAGTCTCATGGCAGTCCCAAAGGAGGCTTACAACTCCTGCATCACAAGAAAAAG GAAGCCACTGCCAGCTGGGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCACCCCTCAGACTGGGTTCCTCTCCAAGCTCGCCCTCTGGAGGG GCAGCGCAGCCTCCCACCAAGGGCCCTGCGACCACAGCAGGGATTGGGATGAATTGCCTGTCCTGGATCTGCTCTAGAGGCCCAAGCTGCCTGCCTGAGG AAGGATGACTTGACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAGAGCACCTCAGCCCGCTGACCTTGCACAAACTCCATCTGCTGCCATGAGAAA AGGGAAGCCGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCCAATTCTGCCACTTCTGGTTTGGGTACAGTTAAAGGCAACCCTG AGGGACTTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTCGTGTGCAGCTAGAGCTTTACCTGAAAGGAAGTCTCTGGGCCCAGAACTCTC CACCAAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGTTGAAGGGATCTGAGAAGGAGAAGGAAATGTGGGGTAGATTTGGTGGTGGTT AGAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTCACGCACCTCGGTTCCTCTTCCTGAAGTTCTTGTGCCCTGCTCTTCAGCACC ATGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGGCAGGCTCTTGGGGCCAGCCTAAGATCATGGTTTAGGGTGATCAGTGCTGGCAG ATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCCCCCAGGGCTGGGCACTCCTCCCCTCCCCTCACTTCTCCCACCTGCAGAGCC AGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTTCAAGCTGCTGACTCACTTTATCAATAGTTCCATTTAAATTGACTTCAGTGGTG AGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGGGGGAGGAATGTGTAAGATAGTTAACATGGGCAAAGGGAGATCTTGGGGTGCAGC ACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTTGCTAGAGGGAGGGAGCAGCCACGGAGTTAGAGGCCCTTGGGGTTTCTCTTTTCCAC TGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCCAGCCAGGTGCAGGCGTAGGAATATGGACATCTGGTTGCTTTGGCCTGCTGCCCTCTTT CAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTTGGCATCCTTCCCTCTAAGCCGTTGGCACCTCTGTGCCACCTCTCACACTGGCTCCAGACA CACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCACCCTCCTCATCTTTGTTCTCCAAGTAAAGCCACGAGGTCGGGGCGAGGGCAGAGGTGATCAC CTGCGTGTCCCATCTACAGACCTGCGGCTTCATAAAACTTCTGATTTCTCTTCAGCTTTGAAAAGGGTTACCCTGGGCACTGGCCTAGAGCCTCACCTCC TAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGCAGGACTATTTCTGGCACTTGCAAGTCCCATGATTTCTTCGGTAATTCTGAGGGTGGGGGGAGGG ACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTGAATGTCTATATAGTGTATTGTGTGTTTTAACAAATGATTTACACTGACTGTTGCTGTAAAAGTGA ATTTGGAAATAAAGTTATTACTCTGATTAAA

refseq_MAPT.F5 (forward primer)
refseq_MAPT.R5 (reverse primer)
Multiple exon skipping

Frame 0

PPLGRLAFPLLAPAPPAGLRNAPSSPARALAVT ATHQLRHQQQRRCHRPPSAAATTATFSSSAVLSR PRLCRLSGEL*TRMAEPRQEFEVMEDHAGTYGL GDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTE DGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGK QAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG HVTQARMVSKSKDGTGSDDKKAKGADGKTKIAT PRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGE PPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPT REPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDL KNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNV QSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTS KCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSK IGSLDNITHVPGGGNKKIETHKLTFRENAKAKTD HGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV DSPQLATLADEVSASLAKQGL*SGPWGGQ*LWR GENERVWKKKE**PGPRPLPPAAPRSSVNWLIT* PAFVTRLWLGTSKSVMGVRANFIFPN*WVG*** NI*KKTFKNMATSNISSGNSF*FFFLPPPCRRG RRRGSESCFWGISRDWGCQPPLALLWGCHRGSGS NKGFETWCVRGATGRRCQPCVSVTGVGVGREAT GEAEAGAGQRGEEAQEVGVGEEATCWRVDIPLL AAGRAKAYATCSV*AAACPWWPGVGACCGSVCHP LQGSLWEKGQRVKREGKLAGGWHFVDDLLRKD* P*CLESAGLFLPPCRVGGLS*GASLCSTETLFY *VLKVGTAAMILATLQTWDFRANQFSL*GLVPLG RRPPVSKPGPLASLECVGVWEAGPEPPVLPTAT AVTPVCAAVLLSAVRAQSLPIPLITRHNVPNSQ PHHPFSVMTLVGCRRYLLHTEGEIKGRQSPGTRV GPQPLTLSSTHPTGTLTTNLMI*FGSLSPPPVT DVSQGTAQL*P*VFLPC*HGESPFP*EGLAPSC AEPTAAGWVSWLSVVAPGWKGKAPRAGPQSRCPP LAP*LVAANLPDSPARCSAPHA*YQPSTPDKGE HTPLEMVLFPQSQLEAMLSVLLEQLNIYIDVAL PSPSAPC*VVVGFVCLCLDSPE*L***KEKKKKK RTHVS*NACKEVSNPPSRGVSHPHTGTRVACVV PPCWGLPSFERLSSAPGTQQRPASSS*GGRSAV TKA*STGLGLKR*CPLPYFPLGLPVSGHRLGLVA GLACGARMVLSGHSPKSHGSPKGGLQLLHHKKK EATASWGDLQLPEAP*ASATPQTGFLSKLALWR GSAASHQGPCDHSRDWDELPVLDLL*RPKLPA*G RMT*QVRRHCSQSLDQSTSAR*PCTNSICCHEK REAAFAKHCCLKKLSSLRPNSATSGLGTVKGNP EGLGSRNPGPPLGLAASCAARALPERKSLGPELS TKSLPAVR*VPAILLS*RDLRRRRKCGVDLVVV RDMPPSLLPTVSAAFLHAPRFLFLKFLCPALQH HGPSYTEGSGISPLWGQALGASLRSWFRVISAGR *IEKARWLVILNEDNPPRAGHSSPPLTSPTCRA SVLGWAR*DILYAGSFKLLTHFINSSI*IDFSG ETVSCLLLLVVLWGEGGGMCKIVNMGKGRSWGAA LKLPRNPFHDFNHIC*REGAATELEALGVSLFH *QAFPGSWLVHSLPSQVQA*EYGHLVALACCPL SGVLSPQSCLPKTLASFPLSRWHLCATSHTGSRH TACAFGAEITRFTLLIFVLQVKPRGRGEGRGDH LRVPSTDLRLHKTSDFSSALKRVTLGTGLEPHL LIDLAP*VCHVEQDYFWHLQVP*FLR*F*GWGEG HEIILA*LSVCECLYSVLCVLTNDLH*LLL*K* IWK*SYYSD*

Frame 1

LPWGGSRSRCSRLRRPPASGTRPLRRRAPSQSP PPTSSGTNSSAAATAHLLPPPPQPPSPPPLSSP VLASVDYQVNFEPGWLSPARSSK*WKITLGRTGW GTGKIRGATPCTKTKRVTRTLA*KNLPCRPPLR TDLRNRALKPLMLRALQQRKM*QHP*WMRELPA SRLPRSPTRRSQKEPQLKKQALETPPAWKTKLLV T*PKLAWSVKAKTGLEAMTKKPRGLMVKRRSPH RGEQPLQARRARPTPPGFQQKPRPLQRHHPALV NLQNQGIAAATAAPAPQALPAAAPAPRPFQPHPP GSPRRWQWSVLHPSRRLPPRAACRQPPCPCQT* RMSSPRSAPLRT*STSREAGRCR*LIRSWILAT SSPSVAQRIISNTSREAAVCK*STNQLT*AR*PP SVAH*ATSIINQEVARWK*NLRSLTSRTESSRR LGPWTISPTSLAEEIKRLKPTS*PSARTPKPRQ TTGRRSCTSRQWCLGTRLHGISAMSPPPAASTW* TRPSSPR*LTRCLPPWPSRVCDQAPGAVNNCGE ERMRECGKKKNNDPAPALCPQLLLAVRLIG*SL NLLLSLGFGSGLQNQ*WE*EQISSFQIDGWASNK IFKKKHSKTWPHPTFPQAIPFDSFFFPLHVEEG EGEALKAASGGFQGTGGANHLWPCCGGVTEAVA ATKDLKLGVFVEPQADDVNLV*V*RGLGWGGRPR GRPRQGLGRGERKHKKWEWERKPRAGE*TSPSL PLGEPRPMPPAASERPPVLGGRGWGPAVGQCAT LCRAACGRRDSG*KEKASWQEGGTSWMTSLEKTD LDVLRALASSSLPAG*GA*VEGLPSAPQKPCFI EF*RLELLP*FWPLCRPGTLGLTSSLCKDLCLL GDVHPFPSLGHWHLWSVWGSGRQVPSPLSFPRPL QSPLSAPLCCCLP*EPNHCLYPSSHVTMSRIPS LTTPSQ**PWLVAGGTYSILRVKLREGKVQAQE WDPSLSLSVPLIQLGPSPRIS*SDSVPCLLLPSQ M*ARALLSCDPRCFCLVDMERALSPEKAWPLPV LSPQQQAGCLGCQWWHQDGRARHPGQAHSPAVP HLHPSL*LPTSQTAQPAAQLHMHSISPPHPTKGN TPPWKWFFSPSPSWKPCCLFCWSS*TYT*MLPC PPHLHPVEL*LDLSVYAWIHQSDYDSEKKKKKK KGRMYLEMLVKRFLTHPHEVSLTPTLGLVWPVWC HPAGASQVLKGFPQHLGPNRDQLLAAKEAVQL* RRPEAQD*D*SDDVPFPTSPWGSLCQGTD*VLW LVWLAARGWFSLVIARSLMAVPKEAYNSCITRKR KPLPAGGICSSQKLREPQPPLRLGSSPSSPSGG AAQPPTKGPATTAGIGMNCLSWICSRGPSCLPE EG*LDKSGDTVPKALTRAPQPADLAQTPSAAMRK GKPPLQNIAA*RNSAASGPILPLLVWVQLKATL RDLAVEIQGLPWGWQLRVQLELYLKGSLWAQNS PPRASLPFAESQQFS*VEGI*EGEGNVG*IWWWL EICPPHYCQQFRLHFFTHLGSSS*SSCALLFST MGLLIRKALGSPPCGGRLLGPA*DHGLG*SVLA DKLKRHAGL*S*MRTIPPGLGTPPLPSLLPPAEP VSLGGLDRIYCMPAPSSC*LTLSIVPFKLTSVV RLYPVCYCLLCYGGRGEECVR*LTWAKGDLGVQ HLNCLVTLFMISTTFARGREQPRS*RPLGFLFST DRLSQAAG*FIPSPARCRRRNMDIWLLWPAALF QGS*AHNHASLRPWHPSL*AVGTSVPPLTLAPD TQPVLLELRSLASPSSSLFSK*SHEVGARAEVIT CVSHLQTCGFIKLLISLQL*KGLPWALA*SLTS **T*PHEFAMLSRTISGTCKSHDFFGNSEGGGR DMKSS*LSFLSVNVYIVYCVF*QMIYTDCCCKSE FGNKVITLIK

Frame 2

SPGEARVPAARACAARRPQERALFAGARPRSHR HPPAPAPTAAPLPPPTFCRRHHSHLLLLRCPLP SSPLSTIR*TLNQDG*APPGVRSDGRSRWDVRV GGQERSGGLHHAPRPRG*HGRWPERISPADPH*G RI*GTGL*NL*C*EHSNSGRCDSTLSG*GSSRQ AGCRAAPHGDPRRNHS*RSRHWRHPQPGRRSCW SRDPSSHGQ*KQRRDWKR*QKSQGG*W*NEDRHT AGSSPSRPEGPGQRHQDSSKNPARSKDTTQLW* TSKIRGSQRLQQPRLPRHSRQPLPHPVPSNPTH PGAQEGGSGPYSTQVAVFRQEPPADSPRAHARPE ECQVQDRLH*EPEAPAGRREGADN**EAGS*QR PVQVWLKG*YQTRPGRRQCANSLQTS*PEQGDL QVWLIRQHPS*TRRWPGGSKI*EA*LQGQSPVED WVPGQYHPRPWRRK*KD*NPQADLPRERQSQDR PRGGDRVQVASGVWGHVSTASQQCLLHRQHRHG RLAPARHAS*RGVCLPGQAGFVIRPLGRSIIVER RE*ESVEKKRIMTRPPPSAPSCSSQFG*LVNHL TCFCHSALARDFKISDGSKSKFHLSKLMGGLVI KYLKKNIQKHGHIQHFLRQFLLILFSSPSM*KRE KERL*KLLLGDFKGLGVPTTSGPVVGVSQRQWQ QQRI*NLVCSWSHRQTMSTLCECDGGWGGAGGH GGGRGRGWAEGRGSTRSGSGRGSHVLESRHPPPC RWESQGLCHLQRLSGRLSLVAGGGGLLWVSVPP SAGQPVGEGTAGKKRRQAGRRVALRG*PP*KRL TLMS*ERWPLPPSLQGRGPELRGFPLLHRNPVLL SSEGWNCCHDFGHFADLGL*G*PVLFVRTCASW ETSTRFQAWATGISGVCGGLGGRSRAPCPSHGH CSHPCLRRCAVVCRESPITAYTPHHTSQCPEFPA SPPLLSNDPGWLQEVPTPY*G*N*GKAKSRHKS GTPASHSQFHSSNWDPHHESHDLIRFPVSSSRH RCEPGHCSAVTLGVSALLTWREPFPLRRPGPFLC *AHSSRLGVLVVSGGTRMEGQGTQGRPTVPLSP TCTLACSCQPPRQPSPLLSSTCIVSALHTRQRG THPLGNGSFPPVPAGSHAVCSAGAAEHIHRCCPA LPICTLLSCSWICLFMLGFTRVTMIVKRKKKKK KDACILKCL*RGF*PTLTRCLSPPHWDSCGLCG ATLLGPPKF*KAFLSTWDPTETSF*QLRRPFSCD EGLKHRIRTEAMMSPSLLPLGAPCVRAQTRSCG WSGLRREDGSLWS*PEVSWQSQRRLTTPASQEK GSHCQLGGSAAPRSSVSLSHPSDWVPLQARPLEG QRSLPPRALRPQQGLG*IACPGSALEAQAACLR KDDLTSQETLFPKP*PEHLSPLTLHKLHLLP*E KGSRLCKTLLPKETQQPQAQFCHFWFGYS*RQP* GTWQ*KSRASPGAGSFVCS*SFT*KEVSGPRTL HQEPPCRSLSPSNSPKLKGSEKEKEMWGRFGGG *RYAPLITANSFGCISSRTSVPLPEVLVPCSSAP WAFLYGRLWDLPLVGAGSWGQPKIMV*GDQCWQ IN*KGTLACDLK*GQSPQGWALLPSPHFSHLQS QCPWVG*IGYTVCRLLQAADSLYQ*FHLN*LQW* DCILFAIACCAMGGGGRNV*DS*HGQREILGCS T*TAS*PFS*FQPHLLEGGSSHGVRGPWGFSFP LTGFPRQLASSFPPQPGAGVGIWTSGCFGLLPSF RGPKPTIMPP*DLGILPSKPLAPLCHLSHWLQT HSLCFWS*DHSLHPPHLCSPSKATRSGRGQR*S PACPIYRPAAS*NF*FLFSFEKGYPGHWPRASPP NRLSPMSLPC*AGLFLALASPMISSVILRVGGG T*NHLSLAFCL*MSI*CIVCFNK*FTLTVAVKV NLEIKLLL*L

Sequence NM_016835

CCTCCCCTGGGGAGGCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAACGCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCG CCACCCACCAGCTCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGCCACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCG TCCTCGCCTCTGTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTG GGGGACAGGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGAATCTCCCCTGCAGACCCCCACTGAGG ACGGATCTGAGGAACCGGGCTCTGAAACCTCTGATGCTAAGAGCACTCCAACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCGGCAA GCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACAGCTGAAGAAGCAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCTGCTGGT CACGTGACCCAAGAGCCTGAAAGTGGTAAGGTGGTCCAGGAAGGCTTCCTCCGAGAGCCAGGCCCCCCAGGTCTGAGCCACCAGCTCATGTCCGGCATGC CTGGGGCTCCCCTCCTGCCTGAGGGCCCCAGAGAGGCCACACGCCAACCTTCGGGGACAGGACCTGAGGACACAGAGGGCGGCCGCCACGCCCCTGAGCT GCTCAAGCACCAGCTTCTAGGAGACCTGCACCAGGAGGGGCCGCCGCTGAAGGGGGCAGGGGGCAAAGAGAGGCCGGGGAGCAAGGAGGAGGTGGATGAA GACCGCGACGTCGATGAGTCCTCCCCCCAAGACTCCCCTCCCTCCAAGGCCTCCCCAGCCCAAGATGGGCGGCCTCCCCAGACAGCCGCCAGAGAAGCCA CCAGCATCCCAGGCTTCCCAGCGGAGGGTGCCATCCCCCTCCCTGTGGATTTCCTCTCCAAAGTTTCCACAGAGATCCCAGCCTCAGAGCCCGACGGGCC CAGTGTAGGGCGGGCCAAAGGGCAGGATGCCCCCCTGGAGTTCACGTTTCACGTGGAAATCACACCCAACGTGCAGAAGGAGCAGGCGCACTCGGAGGAG CATTTGGGAAGGGCTGCATTTCCAGGGGCCCCTGGAGAGGGGCCAGAGGCCCGGGGCCCCTCTTTGGGAGAGGACACAAAAGAGGCTGACCTTCCAGAGC CCTCTGAAAAGCAGCCTGCTGCTGCTCCGCGGGGGAAGCCCGTCAGCCGGGTCCCTCAACTCAAAGCTCGCATGGTCAGTAAAAGCAAAGACGGGACTGG AAGCGATGACAAAAAAGCCAAGACATCCACACGTTCCTCTGCTAAAACCTTGAAAAATAGGCCTTGCCTTAGCCCCAAACACCCCACTCCTGGTAGCTCA GACCCTCTGATCCAACCCTCCAGCCCTGCTGTGTGCCCAGAGCCACCTTCCTCTCCTAAACACGTCTCTTCTGTCACTTCCCGAACTGGCAGTTCTGGAG CAAAGGAGATGAAACTCAAGGGGGCTGATGGTAAAACGAAGATCGCCACACCGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAG GATTCCAGCAAAAACCCCGCCCGCTCCAAAGACACCACCCAGCTCTGGTGAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCA GGCACTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCACCCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGTCGCCGT CTTCCGCCAAGAGCCGCCTGCAGACAGCCCCCGTGCCCATGCCAGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAAGCACCAGCC GGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGATCTTAGCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACACGTCCCGGGAGGC GGCAGTGTGCAAATAGTCTACAAACCAGTTGACCTGAGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAACCAGGAGGTGGCCAGG TGGAAGTAAAATCTGAGAAGCTTGACTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCGGAGGAAATAAAAA GATTGAAACCCACAAGCTGACCTTCCGCGAGAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACG TCTCCACGGCATCTCAGCAATGTCTCCTCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGG CCAAGCAGGGTTTGTGATCAGGCCCCTGGGGCGGTCAATAATTGTGGAGAGGAGAGAATGAGAGAGTGTGGAAAAAAAAAGAATAATGACCCGGCCCCCG CCCTCTGCCCCCAGCTGCTCCTCGCAGTTCGGTTAATTGGTTAATCACTTAACCTGCTTTTGTCACTCGGCTTTGGCTCGGGACTTCAAAATCAGTGATG GGAGTAAGAGCAAATTTCATCTTTCCAAATTGATGGGTGGGCTAGTAATAAAATATTTAAAAAAAAACATTCAAAAACATGGCCACATCCAACATTTCCT CAGGCAATTCCTTTTGATTCTTTTTTCTTCCCCCTCCATGTAGAAGAGGGAGAAGGAGAGGCTCTGAAAGCTGCTTCTGGGGGATTTCAAGGGACTGGGG GTGCCAACCACCTCTGGCCCTGTTGTGGGGGTGTCACAGAGGCAGTGGCAGCAACAAAGGATTTGAAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGA TGTCAACCTTGTGTGAGTGTGACGGGGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCGAGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAG TGGGAGTGGGAGAGGAAGCCACGTGCTGGAGAGTAGACATCCCCCTCCTTGCCGCTGGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGC CTGTCCTTGGTGGCCGGGGGTGGGGGCCTGCTGTGGGTCAGTGTGCCACCCTCTGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGC AAGCTGGCAGGAGGGTGGCACTTCGTGGATGACCTCCTTAGAAAAGACTGACCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGTAG GGGGCCTGAGTTGAGGGGCTTCCCTCTGCTCCACAGAAACCCTGTTTTATTGAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGCAGAC CTGGGACTTTAGGGCTAACCAGTTCTCTTTGTAAGGACTTGTGCCTCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTGGAGTGT GTGGGGGTCTGGGAGGCAGGTCCCGAGCCCCCTGTCCTTCCCACGGCCACTGCAGTCACCCCTGTCTGCGCCGCTGTGCTGTTGTCTGCCGTGAGAGCCC AATCACTGCCTATACCCCTCATCACACGTCACAATGTCCCGAATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAGGAGGTACCT ACTCCATACTGAGGGTGAAATTAAGGGAAGGCAAAGTCCAGGCACAAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCAACTGGGACCCTC ACCACGAATCTCATGATCTGATTCGGTTCCCTGTCTCCTCCTCCCGTCACAGATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAGGTGTTTCTGCCTT GTTGACATGGAGAGAGCCCTTTCCCCTGAGAAGGCCTGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTTGTCAGTGGTGGCACC AGGATGGAAGGGCAAGGCACCCAGGGCAGGCCCACAGTCCCGCTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTCCCAGACAGCCCAGCCCGC TGCTCAGCTCCACATGCATAGTATCAGCCCTCCACACCCGACAAAGGGGAACACACCCCCTTGGAAATGGTTCTTTTCCCCCAGTCCCAGCTGGAAGCCA TGCTGTCTGTTCTGCTGGAGCAGCTGAACATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGTAGTTGGATTTGTCTGTTTATG CTTGGATTCACCAGAGTGACTATGATAGTGAAAAGAAAAAAAAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTTGTAAAGAGGTTTCTAACCCACCC TCACGAGGTGTCTCTCACCCCCACACTGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCTGGGGCCTCCCAAGTTTTGAAAGGCTTTCCTCAGCACCTG GGACCCAACAGAGACCAGCTTCTAGCAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGATTAGGACTGAAGCGATGATGTCCCCTTCC CTACTTCCCCTTGGGGCTCCCTGTGTCAGGGCACAGACTAGGTCTTGTGGCTGGTCTGGCTTGCGGCGCGAGGATGGTTCTCTCTGGTCATAGCCCGAAG TCTCATGGCAGTCCCAAAGGAGGCTTACAACTCCTGCATCACAAGAAAAAGGAAGCCACTGCCAGCTGGGGGGATCTGCAGCTCCCAGAAGCTCCGTGAG CCTCAGCCACCCCTCAGACTGGGTTCCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCCACCAAGGGCCCTGCGACCACAGCAGGGATTGGGA TGAATTGCCTGTCCTGGATCTGCTCTAGAGGCCCAAGCTGCCTGCCTGAGGAAGGATGACTTGACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAG AGCACCTCAGCCCGCTGACCTTGCACAAACTCCATCTGCTGCCATGAGAAAAGGGAAGCCGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCC TCAGGCCCAATTCTGCCACTTCTGGTTTGGGTACAGTTAAAGGCAACCCTGAGGGACTTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTC GTGTGCAGCTAGAGCTTTACCTGAAAGGAAGTCTCTGGGCCCAGAACTCTCCACCAAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGT TGAAGGGATCTGAGAAGGAGAAGGAAATGTGGGGTAGATTTGGTGGTGGTTAGAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTC ACGCACCTCGGTTCCTCTTCCTGAAGTTCTTGTGCCCTGCTCTTCAGCACCATGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGGCA GGCTCTTGGGGCCAGCCTAAGATCATGGTTTAGGGTGATCAGTGCTGGCAGATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCC CCCAGGGCTGGGCACTCCTCCCCTCCCCTCACTTCTCCCACCTGCAGAGCCAGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTTCA AGCTGCTGACTCACTTTATCAATAGTTCCATTTAAATTGACTTCAGTGGTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGGGGG AGGAATGTGTAAGATAGTTAACATGGGCAAAGGGAGATCTTGGGGTGCAGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTTGCTAG AGGGAGGGAGCAGCCACGGAGTTAGAGGCCCTTGGGGTTTCTCTTTTCCACTGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCCAGCCAGG TGCAGGCGTAGGAATATGGACATCTGGTTGCTTTGGCCTGCTGCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTTGGCATCCTT CCCTCTAAGCCGTTGGCACCTCTGTGCCACCTCTCACACTGGCTCCAGACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCACCCTCCTCATC TTTGTTCTCCAAGTAAAGCCACGAGGTCGGGGCGAGGGCAGAGGTGATCACCTGCGTGTCCCATCTACAGACCTGCGGCTTCATAAAACTTCTGATTTCT CTTCAGCTTTGAAAAGGGTTACCCTGGGCACTGGCCTAGAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGCAGGACTATTTCTG GCACTTGCAAGTCCCATGATTTCTTCGGTAATTCTGAGGGTGGGGGGAGGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTGAATGTCTATATAGT GTATTGTGTGTTTTAACAAATGATTTACACTGACTGTTGCTGTAAAAGTGAATTTGGAAATAAAGTTATTACTCTGATTAAA

refseq_MAPT.F5 (forward primer)
refseq_MAPT.R5 (reverse primer)
Multiple exon skipping

Frame 0

PPLGRLAFPLLAPAPPAGLRNAPSSPARALAVT ATHQLRHQQQRRCHRPPSAAATTATFSSSAVLSR PRLCRLSGEL*TRMAEPRQEFEVMEDHAGTYGL GDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTE DGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGK QAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGM PGAPLLPEGPREATRQPSGTGPEDTEGGRHAPEL LKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDE DRDVDESSPQDSPPSKASPAQDGRPPQTAAREA TSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGP SVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEE HLGRAAFPGAPGEGPEARGPSLGEDTKEADLPE PSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTG SDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS DPLIQPSSPAVCPEPPSSPKHVSSVTSRTGSSG AKEMKLKGADGKTKIATPRGAAPPGQKGQANATR IPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSP GTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSP SSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQP GGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGG GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQ VEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKK IETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT SPRHLSNVSSTGSIDMVDSPQLATLADEVSASL AKQGL*SGPWGGQ*LWRGENERVWKKKE**PGPR PLPPAAPRSSVNWLIT*PAFVTRLWLGTSKSVM GVRANFIFPN*WVG***NI*KKTFKNMATSNIS SGNSF*FFFLPPPCRRGRRRGSESCFWGISRDWG CQPPLALLWGCHRGSGSNKGFETWCVRGATGRR CQPCVSVTGVGVGREATGEAEAGAGQRGEEAQE VGVGEEATCWRVDIPLLAAGRAKAYATCSV*AAA CPWWPGVGACCGSVCHPLQGSLWEKGQRVKREG KLAGGWHFVDDLLRKD*P*CLESAGLFLPPCRV GGLS*GASLCSTETLFY*VLKVGTAAMILATLQT WDFRANQFSL*GLVPLGRRPPVSKPGPLASLEC VGVWEAGPEPPVLPTATAVTPVCAAVLLSAVRA QSLPIPLITRHNVPNSQPHHPFSVMTLVGCRRYL LHTEGEIKGRQSPGTRVGPQPLTLSSTHPTGTL TTNLMI*FGSLSPPPVTDVSQGTAQL*P*VFLP C*HGESPFP*EGLAPSCAEPTAAGWVSWLSVVAP GWKGKAPRAGPQSRCPPLAP*LVAANLPDSPAR CSAPHA*YQPSTPDKGEHTPLEMVLFPQSQLEA MLSVLLEQLNIYIDVALPSPSAPC*VVVGFVCLC LDSPE*L***KEKKKKKRTHVS*NACKEVSNPP SRGVSHPHTGTRVACVVPPCWGLPSFERLSSAP GTQQRPASSS*GGRSAVTKA*STGLGLKR*CPLP YFPLGLPVSGHRLGLVAGLACGARMVLSGHSPK SHGSPKGGLQLLHHKKKEATASWGDLQLPEAP* ASATPQTGFLSKLALWRGSAASHQGPCDHSRDWD ELPVLDLL*RPKLPA*GRMT*QVRRHCSQSLDQ STSAR*PCTNSICCHEKREAAFAKHCCLKKLSS LRPNSATSGLGTVKGNPEGLGSRNPGPPLGLAAS CAARALPERKSLGPELSTKSLPAVR*VPAILLS *RDLRRRRKCGVDLVVVRDMPPSLLPTVSAAFL HAPRFLFLKFLCPALQHHGPSYTEGSGISPLWGQ ALGASLRSWFRVISAGR*IEKARWLVILNEDNP PRAGHSSPPLTSPTCRASVLGWAR*DILYAGSF KLLTHFINSSI*IDFSGETVSCLLLLVVLWGEGG GMCKIVNMGKGRSWGAALKLPRNPFHDFNHIC* REGAATELEALGVSLFH*QAFPGSWLVHSLPSQ VQA*EYGHLVALACCPLSGVLSPQSCLPKTLASF PLSRWHLCATSHTGSRHTACAFGAEITRFTLLI FVLQVKPRGRGEGRGDHLRVPSTDLRLHKTSDF SSALKRVTLGTGLEPHLLIDLAP*VCHVEQDYFW HLQVP*FLR*F*GWGEGHEIILA*LSVCECLYS VLCVLTNDLH*LLL*K*IWK*SYYSD*

Frame 1

LPWGGSRSRCSRLRRPPASGTRPLRRRAPSQSP PPTSSGTNSSAAATAHLLPPPPQPPSPPPLSSP VLASVDYQVNFEPGWLSPARSSK*WKITLGRTGW GTGKIRGATPCTKTKRVTRTLA*KNLPCRPPLR TDLRNRALKPLMLRALQQRKM*QHP*WMRELPA SRLPRSPTRRSQKEPQLKKQALETPPAWKTKLLV T*PKSLKVVRWSRKASSESQAPQV*ATSSCPAC LGLPSCLRAPERPHANLRGQDLRTQRAAATPLS CSSTSF*ETCTRRGRR*RGQGAKRGRGARRRWMK TATSMSPPPKTPLPPRPPQPKMGGLPRQPPEKP PASQASQRRVPSPSLWISSPKFPQRSQPQSPTG PV*GGPKGRMPPWSSRFTWKSHPTCRRSRRTRRS IWEGLHFQGPLERGQRPGAPLWERTQKRLTFQS PLKSSLLLLRGGSPSAGSLNSKLAWSVKAKTGL EAMTKKPRHPHVPLLKP*KIGLALAPNTPLLVAQ TL*SNPPALLCAQSHLPLLNTSLLSLPELAVLE QRR*NSRGLMVKRRSPHRGEQPLQARRARPTPP GFQQKPRPLQRHHPALVNLQNQGIAAATAAPAPQ ALPAAAPAPRPFQPHPPGSPRRWQWSVLHPSRR LPPRAACRQPPCPCQT*RMSSPRSAPLRT*STS REAGRCR*LIRSWILATSSPSVAQRIISNTSREA AVCK*STNQLT*AR*PPSVAH*ATSIINQEVAR WK*NLRSLTSRTESSRRLGPWTISPTSLAEEIK RLKPTS*PSARTPKPRQTTGRRSCTSRQWCLGTR LHGISAMSPPPAASTW*TRPSSPR*LTRCLPPW PSRVCDQAPGAVNNCGEERMRECGKKKNNDPAP ALCPQLLLAVRLIG*SLNLLLSLGFGSGLQNQ*W E*EQISSFQIDGWASNKIFKKKHSKTWPHPTFP QAIPFDSFFFPLHVEEGEGEALKAASGGFQGTG GANHLWPCCGGVTEAVAATKDLKLGVFVEPQADD VNLV*V*RGLGWGGRPRGRPRQGLGRGERKHKK WEWERKPRAGE*TSPSLPLGEPRPMPPAASERP PVLGGRGWGPAVGQCATLCRAACGRRDSG*KEKA SWQEGGTSWMTSLEKTDLDVLRALASSSLPAG* GA*VEGLPSAPQKPCFIEF*RLELLP*FWPLCR PGTLGLTSSLCKDLCLLGDVHPFPSLGHWHLWSV WGSGRQVPSPLSFPRPLQSPLSAPLCCCLP*EP NHCLYPSSHVTMSRIPSLTTPSQ**PWLVAGGT YSILRVKLREGKVQAQEWDPSLSLSVPLIQLGPS PRIS*SDSVPCLLLPSQM*ARALLSCDPRCFCL VDMERALSPEKAWPLPVLSPQQQAGCLGCQWWH QDGRARHPGQAHSPAVPHLHPSL*LPTSQTAQPA AQLHMHSISPPHPTKGNTPPWKWFFSPSPSWKP CCLFCWSS*TYT*MLPCPPHLHPVEL*LDLSVY AWIHQSDYDSEKKKKKKKGRMYLEMLVKRFLTHP HEVSLTPTLGLVWPVWCHPAGASQVLKGFPQHL GPNRDQLLAAKEAVQL*RRPEAQD*D*SDDVPF PTSPWGSLCQGTD*VLWLVWLAARGWFSLVIARS LMAVPKEAYNSCITRKRKPLPAGGICSSQKLRE PQPPLRLGSSPSSPSGGAAQPPTKGPATTAGIG MNCLSWICSRGPSCLPEEG*LDKSGDTVPKALTR APQPADLAQTPSAAMRKGKPPLQNIAA*RNSAA SGPILPLLVWVQLKATLRDLAVEIQGLPWGWQL RVQLELYLKGSLWAQNSPPRASLPFAESQQFS*V EGI*EGEGNVG*IWWWLEICPPHYCQQFRLHFF THLGSSS*SSCALLFSTMGLLIRKALGSPPCGG RLLGPA*DHGLG*SVLADKLKRHAGL*S*MRTIP PGLGTPPLPSLLPPAEPVSLGGLDRIYCMPAPS SC*LTLSIVPFKLTSVVRLYPVCYCLLCYGGRG EECVR*LTWAKGDLGVQHLNCLVTLFMISTTFAR GREQPRS*RPLGFLFSTDRLSQAAG*FIPSPAR CRRRNMDIWLLWPAALFQGS*AHNHASLRPWHP SL*AVGTSVPPLTLAPDTQPVLLELRSLASPSSS LFSK*SHEVGARAEVITCVSHLQTCGFIKLLIS LQL*KGLPWALA*SLTS**T*PHEFAMLSRTIS GTCKSHDFFGNSEGGGRDMKSS*LSFLSVNVYIV YCVF*QMIYTDCCCKSEFGNKVITLIK

Frame 2

SPGEARVPAARACAARRPQERALFAGARPRSHR HPPAPAPTAAPLPPPTFCRRHHSHLLLLRCPLP SSPLSTIR*TLNQDG*APPGVRSDGRSRWDVRV GGQERSGGLHHAPRPRG*HGRWPERISPADPH*G RI*GTGL*NL*C*EHSNSGRCDSTLSG*GSSRQ AGCRAAPHGDPRRNHS*RSRHWRHPQPGRRSCW SRDPRA*KW*GGPGRLPPRARPPRSEPPAHVRHA WGSPPA*GPQRGHTPTFGDRT*GHRGRPPRP*A AQAPASRRPAPGGAAAEGGRGQREAGEQGGGG* RPRRR*VLPPRLPSLQGLPSPRWAASPDSRQRSH QHPRLPSGGCHPPPCGFPLQSFHRDPSLRARRA QCRAGQRAGCPPGVHVSRGNHTQRAEGAGALGG AFGKGCISRGPWRGARGPGPLFGRGHKRG*PSRA L*KAACCCSAGEARQPGPSTQSSHGQ*KQRRDW KR*QKSQDIHTFLC*NLEK*ALP*PQTPHSW*L RPSDPTLQPCCVPRATFLS*TRLFCHFPNWQFWS KGDETQGG*W*NEDRHTAGSSPSRPEGPGQRHQ DSSKNPARSKDTTQLW*TSKIRGSQRLQQPRLP RHSRQPLPHPVPSNPTHPGAQEGGSGPYSTQVAV FRQEPPADSPRAHARPEECQVQDRLH*EPEAPA GRREGADN**EAGS*QRPVQVWLKG*YQTRPGR RQCANSLQTS*PEQGDLQVWLIRQHPS*TRRWPG GSKI*EA*LQGQSPVEDWVPGQYHPRPWRRK*K D*NPQADLPRERQSQDRPRGGDRVQVASGVWGH VSTASQQCLLHRQHRHGRLAPARHAS*RGVCLPG QAGFVIRPLGRSIIVERRE*ESVEKKRIMTRPP PSAPSCSSQFG*LVNHLTCFCHSALARDFKISD GSKSKFHLSKLMGGLVIKYLKKNIQKHGHIQHFL RQFLLILFSSPSM*KREKERL*KLLLGDFKGLG VPTTSGPVVGVSQRQWQQQRI*NLVCSWSHRQT MSTLCECDGGWGGAGGHGGGRGRGWAEGRGSTRS GSGRGSHVLESRHPPPCRWESQGLCHLQRLSGR LSLVAGGGGLLWVSVPPSAGQPVGEGTAGKKRR QAGRRVALRG*PP*KRLTLMS*ERWPLPPSLQGR GPELRGFPLLHRNPVLLSSEGWNCCHDFGHFAD LGL*G*PVLFVRTCASWETSTRFQAWATGISGV CGGLGGRSRAPCPSHGHCSHPCLRRCAVVCRESP ITAYTPHHTSQCPEFPASPPLLSNDPGWLQEVP TPY*G*N*GKAKSRHKSGTPASHSQFHSSNWDP HHESHDLIRFPVSSSRHRCEPGHCSAVTLGVSAL LTWREPFPLRRPGPFLC*AHSSRLGVLVVSGGT RMEGQGTQGRPTVPLSPTCTLACSCQPPRQPSP LLSSTCIVSALHTRQRGTHPLGNGSFPPVPAGSH AVCSAGAAEHIHRCCPALPICTLLSCSWICLFM LGFTRVTMIVKRKKKKKKDACILKCL*RGF*PT LTRCLSPPHWDSCGLCGATLLGPPKF*KAFLSTW DPTETSF*QLRRPFSCDEGLKHRIRTEAMMSPS LLPLGAPCVRAQTRSCGWSGLRREDGSLWS*PE VSWQSQRRLTTPASQEKGSHCQLGGSAAPRSSVS LSHPSDWVPLQARPLEGQRSLPPRALRPQQGLG *IACPGSALEAQAACLRKDDLTSQETLFPKP*P EHLSPLTLHKLHLLP*EKGSRLCKTLLPKETQQP QAQFCHFWFGYS*RQP*GTWQ*KSRASPGAGSF VCS*SFT*KEVSGPRTLHQEPPCRSLSPSNSPK LKGSEKEKEMWGRFGGG*RYAPLITANSFGCISS RTSVPLPEVLVPCSSAPWAFLYGRLWDLPLVGA GSWGQPKIMV*GDQCWQIN*KGTLACDLK*GQS PQGWALLPSPHFSHLQSQCPWVG*IGYTVCRLLQ AADSLYQ*FHLN*LQW*DCILFAIACCAMGGGG RNV*DS*HGQREILGCST*TAS*PFS*FQPHLL EGGSSHGVRGPWGFSFPLTGFPRQLASSFPPQPG AGVGIWTSGCFGLLPSFRGPKPTIMPP*DLGIL PSKPLAPLCHLSHWLQTHSLCFWS*DHSLHPPH LCSPSKATRSGRGQR*SPACPIYRPAAS*NF*FL FSFEKGYPGHWPRASPPNRLSPMSLPC*AGLFL ALASPMISSVILRVGGGT*NHLSLAFCL*MSI* CIVCFNK*FTLTVAVKVNLEIKLLL*L