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Sequences

Sequence NM_001005619

GGAAGAGGATGGCAGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAACCGCTGCAA GAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAG GCGGAGCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGAGGAGACCCAGATTGACACCACCCTGCGGC GCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGA CCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAACCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACC AGCGACTACACTATTGGATTTGGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTGGCCCAACAGTG ACCCCCCCTTCTCCTTCAAGAACGTCATCAGCCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGC TCCTGAGGGCGGCTTCGATGCCATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAG TCAGCCTTCCACTATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCC AGTACAGGACACAGGACTACCCGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTACTCCTATAG CTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAAT CGGATCCGCTCCAACCTGGACATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGATGTTCCAGAAGACGAGGACTGGGTCCT TTCACATCCGGCGGGGGGAAGTGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAA GGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCCTCAAGATGGACGCGGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGG TCAGCTCGCTGCAGCTTCAACGGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCTCCACCGGCTCTCTGA GTGACATTCAGCCCTGCCTGCGGGAGGGCGAGGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTA CGAGGGTCAGTTCTGCGAGTATGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGT GAGCCTGGTTGGACAGGCCCAAGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGT GTGGCCGCTGCCACTGCCACCAGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGACCTACGCTC CTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGTGGACGAGCTTAAGAGAGCC GAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTG TCCTGGTGCACAAGAAGAAGGACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCT ATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCCGTGCTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTG CGGGAGAACCTGATGGCCTCTGACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACA TGCAGCGGCCTGGCTTTGCCACTCATGCCGCCAGCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAA CCTGCTGAAGCCTGACACTCGGGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTC CAGCAGACCAAGTTCCGGCAGCAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCC TGCTGAAGCTTACAGAGAAGCAGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGACGCCCGGGG CATGGTGGAGTTCCAGGAGGGCGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGTGGAGGCC ATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGCCAGAGACGTGGTGTCCTTTGAGCAGCCTG AGTTCTCGGTCAGCCGCGGGGACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTACCGCACACAGGATGG CACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTGTTCCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTG CAAGAAGTTGACTCCCTCCTGCGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTCCA CCACCATCATCATCAGGGACCCAGATGAACTGGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCA GAACCCCAATGCTAAGGCCGCTGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAG GGTGACTCCGAATCCGAAGCCCACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCG CCTACGGGGCTCAGGGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGT CTCCTCCACGGTGACCCAGCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGGCCTGGTCAACGATGACAAC CGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGG TGAAGGCGCGCAACGGGGCCGGCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCTGA CATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTTCCTTATGTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGC GTCTCCGATGACACTGAGCACCTGGTGAATGGCCGGATGGACTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTG CCTATGGCACCCACCTGAGCCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTGACCCGCTCAGAACACTC ACACTCGACCACACTGCCCAGGGACTACTCCACCCTCACCTCCGTCTCCTCCCACGGCCTCCCTCCCATCTGGGAACACGGGAGGAGCAGGCTTCCGCTG TCCTGGGCCCTGGGGTCCCGGAGTCGGGCTCAGATGAAAGGGTTCCCCCCTTCCAGGGGCCCACGAGACTCTATAATCCTGGCTGGGAGGCCAGCAGCGC CCTCCTGGGGCCCAGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCCACATCTCTCAGAGTGAGCTG GCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAGCTGCATCGGCTCAACATCCCCAACCCTGCC CAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCAGGAAGGCTGGGGCCGAGAGCGTGAGGGTG TCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGCCTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGT GTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATGGGGATATCGTCGGCTACCTGGTGACCTGTGAGATGGCC CAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGAACGTGCCCTACAAGTTCA AGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCG TGCCGGGCTCTTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCTTCCTAGTGGATGGGCTGACCCTG GGGGCCCAGCACCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACA TGGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCCCGACTCCTCTCCCGGAGCCTCCTCAGCTAC TCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGGGGCAAGGTCCGTCCTCTGTG GGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAAATGGTTTTGCTACTGCTA

refseq_ITGB4.F3 (forward primer)
refseq_ITGB4.R3 (reverse primer)
Single exon skipping

Frame 0

GRGWQGHAPAHGPGCSWQP*SASASLGPWQTAA RRPQ*RAARSVSVWIRTAPTAQTRCSGTGAATPR RSCWPRAASGRASWSWRAASKSQRRPRLTPPCG AARCPPKACGSVCGPVRSGILSWRCLSHWRAPW TCTSSWTSPTPCPMIWTTSRRWGRTWLGS*ASSP ATTLLDLASLWTKSASRRRT*GLRS*RSPGPTV TPPSPSRTSSA*QKMWMSSGINCRESGSQATWM LLRAASMPSCRQLCARGTLAGARTAPTCWSSPPS QPSTMRLMAPTCWLAS*AATMNGATWTPRAPTP STGHRTTRRCPPWCACSPSTTSSPSLLSPTTPI ATTRSFTPISLSPHWGCCRRTRPTSWSCWRRPSI GSAPTWTSGP*TAPEAFGQRSPPRCSRRRGLGP FTSGGGKWVYTRCSCGPLSTWMGRTCASCRRTR RATSI*NLPSPTASRWTRASSVMCAPASCKKRCG QLAAASTETSCADSVCAARAGVARPATAPPAL* VTFSPACGRARTSRAPAVGSASAGTVCATAKAA TRVSSASMTTSSVPALPGSSAMTEDAAPWASVCV SLVGQAQAVTVPSAMPPASTAMGASVMDVATVS VAAATATSSRSTRTPSARSTTRRSTRASARTYA PACSARRGAPARRRGARVRNATSRSRWWTSLREP RRWWCAAPSGTRMTTAPTATPWKVTAPLGPTAL SWCTRRRTALRAPSGGSSPCSSSSCRSWPCYCC YAGSTVPAARPAWHFSRAATEVTWWALRKTTTCC GRT*WPLTTWTRPCCAAGTSRAVTWSAGRSPTT CSGLALPLMPPASTPQSWCPTGCPCAWPAFAPR TC*SLTLGSAPSCARRWRRT*TRSTGRSPVYTSS SRPSSGSSPMPGKSKTTPLWTQC*WRPARPSRP C*SLQRSRWNRGPSTTSRWPPATTPSLQTRTPG AWWSSRRAWSWWTYGCPSLSGLRMTTRSSCWWRP STCPQALPPSAAAW*TSPSSRSKPETWCPLSSL SSRSAAGTRWPASLSSGVSWTAGSPRSPTAHRM APRRATGTTSPWRVSCCSSLGRPGKSCR*SSWSC KKLTPSCGAARSAVSTSSSATLSLGPTWASPTP PPSSSGTQMNWTGASRVRCCHHSHPLTATWAPR RTPMLRPLGPGRSISTGCPLLASQWGTG*STGFR VTPNPKPTCSTARCPQWSSPTCTRIATMR*RCA PTGLRARDPTAPWCPAAPTRKCPASQGVWPSMS SPPR*PS*AGLSRLRPTVRSQPTRSAMAWSTMTT DLLGP*RKCWLTTLRTGCCLLRTFGSPSPTATR *RRATGPAGGLSGRPSSTWPPSPRGPCPSPSSL TSLSWTPRAGRTTTASLCTAMTFYALHRAARGPA SPMTLSTW*MAGWTLPSRAAPTPCTG*PRPVLL PMAPT*AHTCPTAC*AHPPPSHGTTTH*PAQNT HTRPHCPGTTPPSPPSPPTASLPSGNTGGAGFRC PGPWGPGVGLR*KGSPLPGAHETL*SWLGGQQR PPGAQTLA*LLVCPTRPPAWCSLPWGPHLSE*A GRSRGASGRCRATVWSTSC*TAVSCIGSTSPTLP RPRWWWKTSCPTTPTCSACGPRARKAGAESVRV SSPLNPRCTRRAHCVPCQAPPSL*ALPVPQARW CSLP*AQTRCS*AGSGHGGPMGISSATW*PVRWP KEEGQPPHSGWMETAPRAG*PCRASARTCPTSS RCRPGPLRASGQSARASSP*SPRMEDPSRSWAA VPGSSSTRCKASTAASPPPTPAPPSPS*WMG*PW GPSTWRQAAPSPGM*PRSL*AGH*PPAEPLAPT WTNSSSKLDRTLPHPRHVPLGVLPTPLPEPPQL LHPCTPGGPAHPHAQSRG*VSPGRHEGGKVRPLW AQTYL*PKSWEQHKDPAFVLHLINGFATA

Frame 1

EEDGRATPQPMGQAAPGSLDQRQPLWDLGKPLQ EGPSEELHGVCPCG*GLRLLHRRDVQGPALQHP GGAAGRGLPAGEHRGHGEQLPNHRGDPD*HHPAA QPDVPPRPAGPSAAR*GAAF*AGGV*ATGEPRG PVHPHGLLQLHVR*SGQPQEDGAEPGSGPEPAH QRLHYWIWQVCGQSQRPADGHEA*EAEGALAQQ* PPLLLQERHQPDRRCG*VPE*TAGRADLRQPGC S*GRLRCHPADSCVHEGHWLAPGQHPPAGLLHR VSLPL*G*WRQRAGWHHEPQR*TVPPGHHGHLHP VQDTGLPVGAHPGAPARQAQHHPHLCCHQLLL* LLREASHLFPCLLTGGAAGGLVQHRGAAGGGLQ SDPLQPGHPGPRQPPRPSDRGHLQDVPEDEDWVL SHPAGGSGYIPGAAAGP*ARGWDARVPAAGGPE GQHPSETFLLRRPQDGRGHHL*CVHLRAAKRGA VSSLQLQRRLRVRTVCVQRGLEWPDLQLLHRLSE *HSALPAGGRGQAVLRPWGVPVRALCVLRRRPL RGSVLRV*QLPVSPHFRVPLQ*PRTLLHGPVCV *AWLDRPKL*LSPQQCHLHRQQWGHL*WTWPL*V WPLPLPPAVALHGHHLRDQLLGDPPGPLRGPTL LRAVPGVGHRREEGAHV*GMQLQGQDGGRA*ES RGGGGALLLPGRG*RLHLQLHHGR*RRPWAQQHC PGAQEEGLPSGLLLVAHPPAPPPPAAPGPATAA MLEVLCLLQGLPGTSPVLQPRSHGGL*GRPLHA AGEPDGL*PLGHAHAAQREPQGP*RGPLEGHQQH AAAWLCHSCRQHQPHRAGALRAVLAPGPPLHRE PAEA*HSGVRPAAPGGGGEPERGLQADLRCTQA PADQVPAAAQCREKARPHHCGHSADGAPLGQAGP AEAYREAGGTEGLPRPQGGPRLLHPHCRPGRPG HGGVPGGRGAGGRTGAPLYPA*G*RREAAAGGG HRRARRHCHPRPPPGKHHHHQGASQRRGVL*AA* VLGQPRGPGGPHPCHPACPGRREVPGLLPHTGW HRAGQPGLHPRGG*AAVPAWGGLERAAGEAPGA ARS*LPPAGPPGPPFPRPAQQP*VWGPPGPAPLH HHHHQGPR*TGPELHESDVVITATPSRRPGRPA EPQC*GRWVQEDPFQLAAPFWQANGVQGKVLDS G*LRIRSPPARQQGALSGAHQPVPVLRL*DEGVR LRGSGRGTLQLPGVLPHPPGSAQRARASGLQCR LLHGDPAELG*AG*DQR*DHSLRGLLWPGQR*Q PTYWAHEESAG*QP*EPDAAY*EPSGVPALPLHG EGAQRGRLGA*AGGHHQPGHPAQEAHVHPHHP* HPYRGRPERGGLRQLPYVQR*RSTLSIGQPEAQ RLR*H*APGEWPDGLCLPGQHQLPAQDDHDQCCC LWHPPEPTRAPPRAKHILHPHTGLQLTDPLRTL TLDHTAQGLLHPHLRLLPRPPSHLGTREEQASA VLGPGVPESGSDERVPPFQGPTRLYNPGWEASSA LLGPRLSPDCWCARHAHPPGVLCPGAHISQSEL AGAAVRAAAAGLQCGVPAAERR*AASAQHPQPC PDLGGGGRPPAQPLLRVPRAGPEPGRLGPRA*GC HHH*IPGAPAEPTVSPARLRLHFEHSQCPRPAG VHCPEPRLAAAELGAATEAQWGYRRLPGDL*DG PRRRASHRIPGGWRQPREPADRAGPQRERALQVQ GAGQDH*GLRARARGHHHHRVPGWRTLPAAGQP CRALPAPAAKRVQQHHHHPHQRHRALPSGWADP GGPAPGGRRLPHPACDPGVCEPDTDHQRNP*HPH GPTVLPNLTAPCPTPATSH*ASSRLLSRSLLSY SILAPLGAQPTRMHRAGARCLLGGMKGARSVLC GPKPICNQRAGSSTRTQPLFCT**MVLLLL

Frame 2

KRMAGPRPSPWARLLLAALISVSLSGTLANRCK KAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQ AELLAAGCQRESIVVMESSFQITEETQIDTTLR RSQMSPQGLRVRLRPGEERHFELEVFEPLESPVD LYILMDFSNSMSDDLDNLKKMGQNLARVLSQLT SDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS DPPFSFKNVISLTEDVDEFRNKLQGERISGNLDA PEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTE SAFHYEADGANVLAGIMSRNDERCHLDTTGTYT QYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYS YYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFN RIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGS FHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQK GNIHLKPSFSDGLKMDAGIICDVCTCELQKEVR SARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSL SDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRY EGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVC EPGWTGPSCDCPLSNATCIDSNGGICNGRGHCE CGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRS CVQCQAWGTGEKKGRTCEECNFKVKMVDELKRA EEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNST VLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLL CWKYCACCKACLALLPCCNRGHMVGFKEDHYML RENLMASDHLDTPMLRSGNLKGRDVVRWKVTNN MQRPGFATHAASINPTELVPYGLSLRLARLCTEN LLKPDTRECAQLRQEVEENLNEVYRQISGVHKL QQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPA LLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARG MVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEA IDVPAGTATLGRRLVNITIIKEQARDVVSFEQP EFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDG TAQGNRDYIPVEGELLFQPGEAWKELQVKLLEL QEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHS TTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQ NPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQ GDSESEAHLLDSKVPSVELTNLYPYCDYEMKVC AYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVV SSTVTQLSWAEPAETNGEITAYEVCYGLVNDDN RPIGPMKKVLVDNPKNRMLLIENLRESQPYRYT VKARNGAGWGPEREAIINLATQPKRPMSIPIIPD IPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPS VSDDTEHLVNGRMDFAFPGSTNSLHRMTTTSAA AYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHS HSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPL SWALGSRSRAQMKGFPPSRGPRDSIILAGRPAA PSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSW QEPRCERPLQGYSVEYQLLNGGELHRLNIPNPA QTSVVVEDLLPNHSYVFRVRAQSQEGWGREREG VITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLV FTALSPDSLQLSWERPRRPNGDIVGYLVTCEMA QGGGPATAFRVDGDSPESRLTVPGLSENVPYKF KVQARTTEGFGPEREGIITIESQDGGPFPQLGSR AGLFQHPLQSEYSSITTTHTSATEPFLVDGLTL GAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTH MDQQFFQT*PHPAPPPPRPTRRPPDSSPGASSAT PSLHPWGPSPPACTEQGLGVSWEA*RGQGPSSV GPNLFVTKELGAAQGPSLCSALNKWFCYC

Sequence NM_001005731

GCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAGCGGCAGCCCA GGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAGGAAGAGGATGGCAGGGCCAC GCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAACCGCTGCAAGAAGGCCCCAGTGAAGAGCTG CACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGAGCTGCTGGCCGCGGGC TGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGAGGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAG GCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCTGTACATCCTCATGGACTT CTCCAACTCCATGTCCGATGATCTGGACAACCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTATTGGATTT GGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGA ACGTCATCAGCCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGGGCGGCTTCGATGC CATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCACTATGAGGCT GATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCAGTACAGGACACAGGACTACC CGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTACTCCTATAGCTACTACGAGAAGCTTCACAC CTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAATCGGATCCGCTCCAACCTGGAC ATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGATGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAG TGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACC TTCCTTCTCCGACGGCCTCAAGATGGACGCGGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCAGCTTCAAC GGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGC GGGAGGGCGAGGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGAGTA TGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTGGACAGGCCCA AGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTGTGGCCGCTGCCACTGCCACC AGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGACCTACGCTCCTGCGTGCAGTGCCAGGCGTG GGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGTGGACGAGCTTAAGAGAGCCGAGGAGGTGGTGGTGCGCTGC TCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGG ACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTG CTGCAAGGCCTGCCTGGCACTTCTCCCGTGCTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCCTCT GACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCA CTCATGCCGCCAGCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCG GGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAAGTTCCGGCAG CAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCTGCTGAAGCTTACAGAGAAGC AGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGACGCCCGGGGCATGGTGGAGTTCCAGGAGGG CGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGTGGAGGCCATCGACGTGCCCGCAGGCACT GCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGCCAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGG ACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTACCGCACACAGGATGGCACCGCGCAGGGCAACCGGGA CTACATCCCCGTGGAGGGTGAGCTGCTGTTCCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACTCCCTCCTG CGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACC CAGATGAACTGGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACCCCAATGCTAAGGCCGC TGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGAATCCGAAGCC CACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCGCCTACGGGGCTCAGGGCGAGG GACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGTCTCCTCCACGGTGACCCAGCT GAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGGCCTGGTCAACGATGACAACCGACCTATTGGGCCCATGAAG AAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCG GCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCTGACATCCCTATCGTGGACGCCCA GAGCGGGGAGGACTACGACAGCTTCCTTATGTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACACTGAGCAC CTGGTGAATGGCCGGATGGACTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGCACCCACCTGAGCC CACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCCAG GGACTACTCCACCCTCACCTCCGTCTCCTCCCACGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCC ACATCTCTCAGAGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAGCTGCATCGGC TCAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCAGGAAGGCTG GGGCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGCCTTCACTTTGAGCACTCCC AGTGCCCCAGGCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATGGGGATATCGTCGGCTACC TGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGA GAACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCC TTCCCGCAGCTGGGCAGCCGTGCCGGGCTCTTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCTTCC TAGTGGATGGGCTGACCCTGGGGGCCCAGCACCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAG CGGAACCCTTAGCACCCACATGGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCCCGACTCCTCT CCCGGAGCCTCCTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGG GGCAAGGTCCGTCCTCTGTGGGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAAATGGTTTTG CTACTGCTA

refseq_ITGB4.F3 (forward primer)
refseq_ITGB4.R3 (reverse primer)
Single exon skipping

Frame 0

ALPASSPPPQPPRPPSDSPCSPARCSPIS*RQP RRGGSESAPR*VQDGRTAAAEAGREREEEDGRAT PQPMGQAAPGSLDQRQPLWDLGKPLQEGPSEEL HGVCPCG*GLRLLHRRDVQGPALQHPGGAAGRG LPAGEHRGHGEQLPNHRGDPD*HHPAAQPDVPPR PAGPSAAR*GAAF*AGGV*ATGEPRGPVHPHGL LQLHVR*SGQPQEDGAEPGSGPEPAHQRLHYWI WQVCGQSQRPADGHEA*EAEGALAQQ*PPLLLQE RHQPDRRCG*VPE*TAGRADLRQPGCS*GRLRC HPADSCVHEGHWLAPGQHPPAGLLHRVSLPL*G *WRQRAGWHHEPQR*TVPPGHHGHLHPVQDTGLP VGAHPGAPARQAQHHPHLCCHQLLL*LLREASH LFPCLLTGGAAGGLVQHRGAAGGGLQSDPLQPG HPGPRQPPRPSDRGHLQDVPEDEDWVLSHPAGGS GYIPGAAAGP*ARGWDARVPAAGGPEGQHPSET FLLRRPQDGRGHHL*CVHLRAAKRGAVSSLQLQ RRLRVRTVCVQRGLEWPDLQLLHRLSE*HSALPA GGRGQAVLRPWGVPVRALCVLRRRPLRGSVLRV *QLPVSPHFRVPLQ*PRTLLHGPVCV*AWLDRP KL*LSPQQCHLHRQQWGHL*WTWPL*VWPLPLPP AVALHGHHLRDQLLGDPPGPLRGPTLLRAVPGV GHRREEGAHV*GMQLQGQDGGRA*ESRGGGGAL LLPGRG*RLHLQLHHGR*RRPWAQQHCPGAQEEG LPSGLLLVAHPPAPPPPAAPGPATAAMLEVLCL LQGLPGTSPVLQPRSHGGL*GRPLHAAGEPDGL *PLGHAHAAQREPQGP*RGPLEGHQQHAAAWLCH SCRQHQPHRAGALRAVLAPGPPLHREPAEA*HS GVRPAAPGGGGEPERGLQADLRCTQAPADQVPA AAQCREKARPHHCGHSADGAPLGQAGPAEAYREA GGTEGLPRPQGGPRLLHPHCRPGRPGHGGVPGG RGAGGRTGAPLYPA*G*RREAAAGGGHRRARRH CHPRPPPGKHHHHQGASQRRGVL*AA*VLGQPRG PGGPHPCHPACPGRREVPGLLPHTGWHRAGQPG LHPRGG*AAVPAWGGLERAAGEAPGAARS*LPP AGPPGPPFPRPAQQP*VWGPPGPAPLHHHHHQGP R*TGPELHESDVVITATPSRRPGRPAEPQC*GR WVQEDPFQLAAPFWQANGVQGKVLDSG*LRIRS PPARQQGALSGAHQPVPVLRL*DEGVRLRGSGRG TLQLPGVLPHPPGSAQRARASGLQCRLLHGDPA ELG*AG*DQR*DHSLRGLLWPGQR*QPTYWAHE ESAG*QP*EPDAAY*EPSGVPALPLHGEGAQRGR LGA*AGGHHQPGHPAQEAHVHPHHP*HPYRGRP ERGGLRQLPYVQR*RSTLSIGQPEAQRLR*H*A PGEWPDGLCLPGQHQLPAQDDHDQCCCLWHPPEP TRAPPRAKHILHPHTGLQLTDPLRTLTLDHTAQ GLLHPHLRLLPRLSPDCWCARHAHPPGVLCPGA HISQSELAGAAVRAAAAGLQCGVPAAERR*AASA QHPQPCPDLGGGGRPPAQPLLRVPRAGPEPGRL GPRA*GCHHH*IPGAPAEPTVSPARLRLHFEHS QCPRPAGVHCPEPRLAAAELGAATEAQWGYRRLP GDL*DGPRRRASHRIPGGWRQPREPADRAGPQR ERALQVQGAGQDH*GLRARARGHHHHRVPGWRT LPAAGQPCRALPAPAAKRVQQHHHHPHQRHRALP SGWADPGGPAPGGRRLPHPACDPGVCEPDTDHQ RNP*HPHGPTVLPNLTAPCPTPATSH*ASSRLL SRSLLSYSILAPLGAQPTRMHRAGARCLLGGMKG ARSVLCGPKPICNQRAGSSTRTQPLFCT**MVL LLL

Frame 1

RCPPRPHPPNPRARPRTVPARPRAAAPSPSGSP GAEGASPPRGRSRTGAQQQPRLAGRGRKRMAGP RPSPWARLLLAALISVSLSGTLANRCKKAPVKSC TECVRVDKDCAYCTDEMFRDRRCNTQAELLAAG CQRESIVVMESSFQITEETQIDTTLRRSQMSPQ GLRVRLRPGEERHFELEVFEPLESPVDLYILMDF SNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGF GKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFK NVISLTEDVDEFRNKLQGERISGNLDAPEGGFDA ILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEA DGANVLAGIMSRNDERCHLDTTGTYTQYRTQDY PSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHT YFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLD IRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGE VGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKP SFSDGLKMDAGIICDVCTCELQKEVRSARCSFN GDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCL REGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEY DNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGP SCDCPLSNATCIDSNGGICNGRGHCECGRCHCH QQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAW GTGEKKGRTCEECNFKVKMVDELKRAEEVVVRC SFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKK DCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCAC CKACLALLPCCNRGHMVGFKEDHYMLRENLMAS DHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFA THAASINPTELVPYGLSLRLARLCTENLLKPDTR ECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQ QPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEK QVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEG VELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGT ATLGRRLVNITIIKEQARDVVSFEQPEFSVSRG DQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRD YIPVEGELLFQPGEAWKELQVKLLELQEVDSLL RGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRD PDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAA GSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEA HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGE GPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQL SWAEPAETNGEITAYEVCYGLVNDDNRPIGPMK KVLVDNPKNRMLLIENLRESQPYRYTVKARNGA GWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQ SGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEH LVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLS PHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPR DYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGP TSLRVSWQEPRCERPLQGYSVEYQLLNGGELHR LNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGW GREREGVITIESQVHPQSPLCPLPGSAFTLSTP SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGY LVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSE NVPYKFKVQARTTEGFGPEREGIITIESQDGGP FPQLGSRAGLFQHPLQSEYSSITTTHTSATEPF LVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTS GTLSTHMDQQFFQT*PHPAPPPPRPTRRPPDSS PGASSATPSLHPWGPSPPACTEQGLGVSWEA*R GQGPSSVGPNLFVTKELGAAQGPSLCSALNKWFC YC

Frame 2

AARLVPTPPTPAPALGQSLLARALQPHLLAAAQ ARRERVRPEVGPGRAHSSSRGWPGEGGRGWQGH APAHGPGCSWQP*SASASLGPWQTAARRPQ*RA ARSVSVWIRTAPTAQTRCSGTGAATPRRSCWPRA ASGRASWSWRAASKSQRRPRLTPPCGAARCPPK ACGSVCGPVRSGILSWRCLSHWRAPWTCTSSWT SPTPCPMIWTTSRRWGRTWLGS*ASSPATTLLDL ASLWTKSASRRRT*GLRS*RSPGPTVTPPSPSR TSSA*QKMWMSSGINCRESGSQATWMLLRAASM PSCRQLCARGTLAGARTAPTCWSSPPSQPSTMRL MAPTCWLAS*AATMNGATWTPRAPTPSTGHRTT RRCPPWCACSPSTTSSPSLLSPTTPIATTRSFT PISLSPHWGCCRRTRPTSWSCWRRPSIGSAPTWT SGP*TAPEAFGQRSPPRCSRRRGLGPFTSGGGK WVYTRCSCGPLSTWMGRTCASCRRTRRATSI*N LPSPTASRWTRASSVMCAPASCKKRCGQLAAAST ETSCADSVCAARAGVARPATAPPAL*VTFSPAC GRARTSRAPAVGSASAGTVCATAKAATRVSSAS MTTSSVPALPGSSAMTEDAAPWASVCVSLVGQAQ AVTVPSAMPPASTAMGASVMDVATVSVAAATAT SSRSTRTPSARSTTRRSTRASARTYAPACSARR GAPARRRGARVRNATSRSRWWTSLREPRRWWCAA PSGTRMTTAPTATPWKVTAPLGPTALSWCTRRR TALRAPSGGSSPCSSSSCRSWPCYCCYAGSTVP AARPAWHFSRAATEVTWWALRKTTTCCGRT*WPL TTWTRPCCAAGTSRAVTWSAGRSPTTCSGLALP LMPPASTPQSWCPTGCPCAWPAFAPRTC*SLTL GSAPSCARRWRRT*TRSTGRSPVYTSSSRPSSGS SPMPGKSKTTPLWTQC*WRPARPSRPC*SLQRS RWNRGPSTTSRWPPATTPSLQTRTPGAWWSSRR AWSWWTYGCPSLSGLRMTTRSSCWWRPSTCPQAL PPSAAAW*TSPSSRSKPETWCPLSSLSSRSAAG TRWPASLSSGVSWTAGSPRSPTAHRMAPRRATG TTSPWRVSCCSSLGRPGKSCR*SSWSCKKLTPSC GAARSAVSTSSSATLSLGPTWASPTPPPSSSGT QMNWTGASRVRCCHHSHPLTATWAPRRTPMLRP LGPGRSISTGCPLLASQWGTG*STGFRVTPNPKP TCSTARCPQWSSPTCTRIATMR*RCAPTGLRAR DPTAPWCPAAPTRKCPASQGVWPSMSSPPR*PS *AGLSRLRPTVRSQPTRSAMAWSTMTTDLLGP*R KCWLTTLRTGCCLLRTFGSPSPTATR*RRATGP AGGLSGRPSSTWPPSPRGPCPSPSSLTSLSWTP RAGRTTTASLCTAMTFYALHRAARGPASPMTLST W*MAGWTLPSRAAPTPCTG*PRPVLLPMAPT*A HTCPTAC*AHPPPSHGTTTH*PAQNTHTRPHCP GTTPPSPPSPPTTLA*LLVCPTRPPAWCSLPWGP HLSE*AGRSRGASGRCRATVWSTSC*TAVSCIG STSPTLPRPRWWWKTSCPTTPTCSACGPRARKA GAESVRVSSPLNPRCTRRAHCVPCQAPPSL*ALP VPQARWCSLP*AQTRCS*AGSGHGGPMGISSAT W*PVRWPKEEGQPPHSGWMETAPRAG*PCRASA RTCPTSSRCRPGPLRASGQSARASSP*SPRMEDP SRSWAAVPGSSSTRCKASTAASPPPTPAPPSPS *WMG*PWGPSTWRQAAPSPGM*PRSL*AGH*PP AEPLAPTWTNSSSKLDRTLPHPRHVPLGVLPTPL PEPPQLLHPCTPGGPAHPHAQSRG*VSPGRHEG GKVRPLWAQTYL*PKSWEQHKDPAFVLHLINGF ATA

Sequence NM_000213

GCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAGCGGCAGCCCA GGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAGGAAGAGGATGGCAGGGCCAC GCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAACCGCTGCAAGAAGGCCCCAGTGAAGAGCTG CACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGAGCTGCTGGCCGCGGGC TGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGAGGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAG GCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCTGTACATCCTCATGGACTT CTCCAACTCCATGTCCGATGATCTGGACAACCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTATTGGATTT GGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGA ACGTCATCAGCCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGGGCGGCTTCGATGC CATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCACTATGAGGCT GATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCAGTACAGGACACAGGACTACC CGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTACTCCTATAGCTACTACGAGAAGCTTCACAC CTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAATCGGATCCGCTCCAACCTGGAC ATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGATGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAG TGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACC TTCCTTCTCCGACGGCCTCAAGATGGACGCGGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCAGCTTCAAC GGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGC GGGAGGGCGAGGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGAGTA TGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTGGACAGGCCCA AGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTGTGGCCGCTGCCACTGCCACC AGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGACCTACGCTCCTGCGTGCAGTGCCAGGCGTG GGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGTGGACGAGCTTAAGAGAGCCGAGGAGGTGGTGGTGCGCTGC TCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGGTGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGG ACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTG CTGCAAGGCCTGCCTGGCACTTCTCCCGTGCTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCCTCT GACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCA CTCATGCCGCCAGCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCG GGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAAGTTCCGGCAG CAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCTGCTGAAGCTTACAGAGAAGC AGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGACGCCCGGGGCATGGTGGAGTTCCAGGAGGG CGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGTGGAGGCCATCGACGTGCCCGCAGGCACT GCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGCCAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGG ACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTACCGCACACAGGATGGCACCGCGCAGGGCAACCGGGA CTACATCCCCGTGGAGGGTGAGCTGCTGTTCCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACTCCCTCCTG CGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACC CAGATGAACTGGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACCCCAATGCTAAGGCCGC TGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGAATCCGAAGCC CACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCGCCTACGGGGCTCAGGGCGAGG GACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCAATGTCGTCTCCTCCACGGTGACCCAGCT GAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGGCCTGGTCAACGATGACAACCGACCTATTGGGCCCATGAAG AAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCTTCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCG GCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCTGACATCCCTATCGTGGACGCCCA GAGCGGGGAGGACTACGACAGCTTCCTTATGTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACACTGGCTGC GGCTGGAAGTTCGAGCCCCTGCTGGGGGAGGAGCTGGACCTGCGGCGCGTCACGTGGCGGCTGCCCCCGGAGCTCATCCCGCGCCTGTCGGCCAGCAGCG GGCGCTCCTCCGACGCCGAGGCGCCCCACGGGCCCCCGGACGACGGCGGCGCGGGCGGGAAGGGCGGCAGCCTGCCCCGCAGTGCGACACCCGGGCCCCC CGGAGAGCACCTGGTGAATGGCCGGATGGACTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGCACC CACCTGAGCCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTGACCCGCTCAGAACACTCACACTCGACCA CACTGCCCAGGGACTACTCCACCCTCACCTCCGTCTCCTCCCACGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGC CCTGGGGCCCACATCTCTCAGAGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAG CTGCATCGGCTCAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCC AGGAAGGCTGGGGCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGCCTTCACTTT GAGCACTCCCAGTGCCCCAGGCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATGGGGATATC GTCGGCTACCTGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGCCGG GCCTCAGCGAGAACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGA TGGAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGGCTCTTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACC GAGCCCTTCCTAGTGGATGGGCTGACCCTGGGGGCCCAGCACCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACAC TGACCACCAGCGGAACCCTTAGCACCCACATGGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCC CGACTCCTCTCCCGGAGCCTCCTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAG GCATGAAGGGGGCAAGGTCCGTCCTCTGTGGGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATA AATGGTTTTGCTACTGCTA

refseq_ITGB4.F3 (forward primer)
refseq_ITGB4.R3 (reverse primer)
Single exon skipping

Frame 0

ALPASSPPPQPPRPPSDSPCSPARCSPIS*RQP RRGGSESAPR*VQDGRTAAAEAGREREEEDGRAT PQPMGQAAPGSLDQRQPLWDLGKPLQEGPSEEL HGVCPCG*GLRLLHRRDVQGPALQHPGGAAGRG LPAGEHRGHGEQLPNHRGDPD*HHPAAQPDVPPR PAGPSAAR*GAAF*AGGV*ATGEPRGPVHPHGL LQLHVR*SGQPQEDGAEPGSGPEPAHQRLHYWI WQVCGQSQRPADGHEA*EAEGALAQQ*PPLLLQE RHQPDRRCG*VPE*TAGRADLRQPGCS*GRLRC HPADSCVHEGHWLAPGQHPPAGLLHRVSLPL*G *WRQRAGWHHEPQR*TVPPGHHGHLHPVQDTGLP VGAHPGAPARQAQHHPHLCCHQLLL*LLREASH LFPCLLTGGAAGGLVQHRGAAGGGLQSDPLQPG HPGPRQPPRPSDRGHLQDVPEDEDWVLSHPAGGS GYIPGAAAGP*ARGWDARVPAAGGPEGQHPSET FLLRRPQDGRGHHL*CVHLRAAKRGAVSSLQLQ RRLRVRTVCVQRGLEWPDLQLLHRLSE*HSALPA GGRGQAVLRPWGVPVRALCVLRRRPLRGSVLRV *QLPVSPHFRVPLQ*PRTLLHGPVCV*AWLDRP KL*LSPQQCHLHRQQWGHL*WTWPL*VWPLPLPP AVALHGHHLRDQLLGDPPGPLRGPTLLRAVPGV GHRREEGAHV*GMQLQGQDGGRA*ESRGGGGAL LLPGRG*RLHLQLHHGR*RRPWAQQHCPGAQEEG LPSGLLLVAHPPAPPPPAAPGPATAAMLEVLCL LQGLPGTSPVLQPRSHGGL*GRPLHAAGEPDGL *PLGHAHAAQREPQGP*RGPLEGHQQHAAAWLCH SCRQHQPHRAGALRAVLAPGPPLHREPAEA*HS GVRPAAPGGGGEPERGLQADLRCTQAPADQVPA AAQCREKARPHHCGHSADGAPLGQAGPAEAYREA GGTEGLPRPQGGPRLLHPHCRPGRPGHGGVPGG RGAGGRTGAPLYPA*G*RREAAAGGGHRRARRH CHPRPPPGKHHHHQGASQRRGVL*AA*VLGQPRG PGGPHPCHPACPGRREVPGLLPHTGWHRAGQPG LHPRGG*AAVPAWGGLERAAGEAPGAARS*LPP AGPPGPPFPRPAQQP*VWGPPGPAPLHHHHHQGP R*TGPELHESDVVITATPSRRPGRPAEPQC*GR WVQEDPFQLAAPFWQANGVQGKVLDSG*LRIRS PPARQQGALSGAHQPVPVLRL*DEGVRLRGSGRG TLQLPGVLPHPPGSAQRARASGLQCRLLHGDPA ELG*AG*DQR*DHSLRGLLWPGQR*QPTYWAHE ESAG*QP*EPDAAY*EPSGVPALPLHGEGAQRGR LGA*AGGHHQPGHPAQEAHVHPHHP*HPYRGRP ERGGLRQLPYVQR*RSTLSIGQPEAQRLR*HWL RLEVRAPAGGGAGPAARHVAAAPGAHPAPVGQQR ALLRRRGAPRAPGRRRRGREGRQPAPQCDTRAP RRAPGEWPDGLCLPGQHQLPAQDDHDQCCCLWH PPEPTRAPPRAKHILHPHTGLQLTDPLRTLTLDH TAQGLLHPHLRLLPRLSPDCWCARHAHPPGVLC PGAHISQSELAGAAVRAAAAGLQCGVPAAERR* AASAQHPQPCPDLGGGGRPPAQPLLRVPRAGPEP GRLGPRA*GCHHH*IPGAPAEPTVSPARLRLHF EHSQCPRPAGVHCPEPRLAAAELGAATEAQWGY RRLPGDL*DGPRRRASHRIPGGWRQPREPADRAG PQRERALQVQGAGQDH*GLRARARGHHHHRVPG WRTLPAAGQPCRALPAPAAKRVQQHHHHPHQRH RALPSGWADPGGPAPGGRRLPHPACDPGVCEPDT DHQRNP*HPHGPTVLPNLTAPCPTPATSH*ASS RLLSRSLLSYSILAPLGAQPTRMHRAGARCLLG GMKGARSVLCGPKPICNQRAGSSTRTQPLFCT** MVLLLL

Frame 1

RCPPRPHPPNPRARPRTVPARPRAAAPSPSGSP GAEGASPPRGRSRTGAQQQPRLAGRGRKRMAGP RPSPWARLLLAALISVSLSGTLANRCKKAPVKSC TECVRVDKDCAYCTDEMFRDRRCNTQAELLAAG CQRESIVVMESSFQITEETQIDTTLRRSQMSPQ GLRVRLRPGEERHFELEVFEPLESPVDLYILMDF SNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGF GKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFK NVISLTEDVDEFRNKLQGERISGNLDAPEGGFDA ILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEA DGANVLAGIMSRNDERCHLDTTGTYTQYRTQDY PSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHT YFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLD IRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGE VGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKP SFSDGLKMDAGIICDVCTCELQKEVRSARCSFN GDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCL REGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEY DNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGP SCDCPLSNATCIDSNGGICNGRGHCECGRCHCH QQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAW GTGEKKGRTCEECNFKVKMVDELKRAEEVVVRC SFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKK DCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCAC CKACLALLPCCNRGHMVGFKEDHYMLRENLMAS DHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFA THAASINPTELVPYGLSLRLARLCTENLLKPDTR ECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQ QPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEK QVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEG VELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGT ATLGRRLVNITIIKEQARDVVSFEQPEFSVSRG DQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRD YIPVEGELLFQPGEAWKELQVKLLELQEVDSLL RGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRD PDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAA GSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEA HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGE GPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQL SWAEPAETNGEITAYEVCYGLVNDDNRPIGPMK KVLVDNPKNRMLLIENLRESQPYRYTVKARNGA GWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQ SGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGC GWKFEPLLGEELDLRRVTWRLPPELIPRLSASS GRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPP GEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGT HLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHST TLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSA LGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGE LHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQS QEGWGREREGVITIESQVHPQSPLCPLPGSAFTL STPSAPGPLVFTALSPDSLQLSWERPRRPNGDI VGYLVTCEMAQGGGPATAFRVDGDSPESRLTVP GLSENVPYKFKVQARTTEGFGPEREGIITIESQD GGPFPQLGSRAGLFQHPLQSEYSSITTTHTSAT EPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRT LTTSGTLSTHMDQQFFQT*PHPAPPPPRPTRRPP DSSPGASSATPSLHPWGPSPPACTEQGLGVSWE A*RGQGPSSVGPNLFVTKELGAAQGPSLCSALN KWFCYC

Frame 2

AARLVPTPPTPAPALGQSLLARALQPHLLAAAQ ARRERVRPEVGPGRAHSSSRGWPGEGGRGWQGH APAHGPGCSWQP*SASASLGPWQTAARRPQ*RA ARSVSVWIRTAPTAQTRCSGTGAATPRRSCWPRA ASGRASWSWRAASKSQRRPRLTPPCGAARCPPK ACGSVCGPVRSGILSWRCLSHWRAPWTCTSSWT SPTPCPMIWTTSRRWGRTWLGS*ASSPATTLLDL ASLWTKSASRRRT*GLRS*RSPGPTVTPPSPSR TSSA*QKMWMSSGINCRESGSQATWMLLRAASM PSCRQLCARGTLAGARTAPTCWSSPPSQPSTMRL MAPTCWLAS*AATMNGATWTPRAPTPSTGHRTT RRCPPWCACSPSTTSSPSLLSPTTPIATTRSFT PISLSPHWGCCRRTRPTSWSCWRRPSIGSAPTWT SGP*TAPEAFGQRSPPRCSRRRGLGPFTSGGGK WVYTRCSCGPLSTWMGRTCASCRRTRRATSI*N LPSPTASRWTRASSVMCAPASCKKRCGQLAAAST ETSCADSVCAARAGVARPATAPPAL*VTFSPAC GRARTSRAPAVGSASAGTVCATAKAATRVSSAS MTTSSVPALPGSSAMTEDAAPWASVCVSLVGQAQ AVTVPSAMPPASTAMGASVMDVATVSVAAATAT SSRSTRTPSARSTTRRSTRASARTYAPACSARR GAPARRRGARVRNATSRSRWWTSLREPRRWWCAA PSGTRMTTAPTATPWKVTAPLGPTALSWCTRRR TALRAPSGGSSPCSSSSCRSWPCYCCYAGSTVP AARPAWHFSRAATEVTWWALRKTTTCCGRT*WPL TTWTRPCCAAGTSRAVTWSAGRSPTTCSGLALP LMPPASTPQSWCPTGCPCAWPAFAPRTC*SLTL GSAPSCARRWRRT*TRSTGRSPVYTSSSRPSSGS SPMPGKSKTTPLWTQC*WRPARPSRPC*SLQRS RWNRGPSTTSRWPPATTPSLQTRTPGAWWSSRR AWSWWTYGCPSLSGLRMTTRSSCWWRPSTCPQAL PPSAAAW*TSPSSRSKPETWCPLSSLSSRSAAG TRWPASLSSGVSWTAGSPRSPTAHRMAPRRATG TTSPWRVSCCSSLGRPGKSCR*SSWSCKKLTPSC GAARSAVSTSSSATLSLGPTWASPTPPPSSSGT QMNWTGASRVRCCHHSHPLTATWAPRRTPMLRP LGPGRSISTGCPLLASQWGTG*STGFRVTPNPKP TCSTARCPQWSSPTCTRIATMR*RCAPTGLRAR DPTAPWCPAAPTRKCPASQGVWPSMSSPPR*PS *AGLSRLRPTVRSQPTRSAMAWSTMTTDLLGP*R KCWLTTLRTGCCLLRTFGSPSPTATR*RRATGP AGGLSGRPSSTWPPSPRGPCPSPSSLTSLSWTP RAGRTTTASLCTAMTFYALHRAARGPASPMTLAA AGSSSPCWGRSWTCGASRGGCPRSSSRACRPAA GAPPTPRRPTGPRTTAARAGRAAACPAVRHPGP PESTW*MAGWTLPSRAAPTPCTG*PRPVLLPMAP T*AHTCPTAC*AHPPPSHGTTTH*PAQNTHTRP HCPGTTPPSPPSPPTTLA*LLVCPTRPPAWCSL PWGPHLSE*AGRSRGASGRCRATVWSTSC*TAVS CIGSTSPTLPRPRWWWKTSCPTTPTCSACGPRA RKAGAESVRVSSPLNPRCTRRAHCVPCQAPPSL *ALPVPQARWCSLP*AQTRCS*AGSGHGGPMGIS SATW*PVRWPKEEGQPPHSGWMETAPRAG*PCR ASARTCPTSSRCRPGPLRASGQSARASSP*SPR MEDPSRSWAAVPGSSSTRCKASTAASPPPTPAPP SPS*WMG*PWGPSTWRQAAPSPGM*PRSL*AGH *PPAEPLAPTWTNSSSKLDRTLPHPRHVPLGVL PTPLPEPPQLLHPCTPGGPAHPHAQSRG*VSPGR HEGGKVRPLWAQTYL*PKSWEQHKDPAFVLHLI NGFATA