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Sequences

Sequence NM_018703

GCCAGGCCGCGTCCGCCATAGTACCTGGCTTGGAGGTGTCGCCGCCGCTCGGTGAGAGCCCCCGAGCGGCAGGGGGCCAACACAAAAAGGGAGCCGGAGA AGCCCTAGCCGCTGCCCAGCAGCTTGCGGGCGTGTTCTCGCGGTTCCGGGCCTCAAGGCGACGGAAACGAAAGGCGAGCGAAGCGCGGAGGATCCGGCGA GAAGAAGCGTCAGGGAGCCTCGGCGGTGTCCCCGGGGTCCGCCGAAGCCACCCGGCCGCCGGCTGGGGCCCGGGGTGGTGAGGAAGTGCTCCGAGGCCTC GCCGAGGCCTAGCGCCGGCTTTGTGTCCGAGGCGGCGGCGGCGGCGGGGGGAGGCGGAGCCGGGGGCGGCCTGCGGGAAGGCCTCTCCTCCGCCGACCGC GCGTTTTCGGCCTAGGCCGTGGGGCCGCTCGTGGCCTCCGGGGAGCAGGCGCCAGGGGTTTGTGTGCGGTGGGGGCCTGGGCCTGGGCCTGGGGAAGCTG ACGCCGGTCGTCCGGAAGCCAGGAGGAGGCGTGAGGCCGCTCGTGGACTCCGGGCCTAGGCCCTCTCCCCTCAACCTTCTCCCGGGGCCTGGGTCACCCC AATCCACGGAGAGAGAGACCCGCCGGGAGGTGCGGCCGCGCTATGGACCCCTGACCCCGTGGGGTCGCTCGGACTCTTAACGTGTGGACTGACCGCTACT GACTGCACCGCCAATCCCCCCGTCTCTGCCGGCCCCTTAGCATGAGCGAGGGGGACCCAGCCGGGTGACATTGTGCCCGTTGGCGGATTCTCGATTTCCC CTCTTCCCCGTCCTCGTCCTCCTCCTCCCCCATGAAGTGATTCTGAGTATCGGGGGGTCTCTGGATTATTGTTCTGACGAACCCCTGCTTGTGGTTGGGG GGTATTTAATCTGAGGCCTTAGGGTCCTTCGGTGTCTTTGAGTGTTTTGTGTGTACATATTTTGCTCTTAAAGTTTATAAATATACGTATATTGAGAGTG TCCACGTCTCCTCGCTGAACCTTAGGAATCCCTTGGCACCATGTCCTGTGTGCATTATAAATTTTCCTCTAAACTCAACTATGATACCGTCACCTTTGAT GGGCTCCACATCTCCCTCTGCGACTTAAAGAAGCAGATTATGGGGAGAGAGAAGCTGAAAGCTGCCGACTGCGACCTGCAGATCACCAATGCGCAGACGA AAGAAGAATATACTGATGATAATGCTCTGATTCCTAAGAATTCTTCTGTAATTGTTAGAAGAATTCCTATTGGAGGTGTTAAATCTACAAGCAAGACATA TGTTATAAGTCGAACTGAACCAGCGATGGCAACTACAAAAGCAATTGATGACTCTTCCGCGTCTATTTCTCTGGCCCAGCTTACAAAGACTGCCAATCTG GCTGAAGCCAATGCTTCTGAAGAAGATAAAATTAAAGCAATGATGTCGCAATCTGGCCATGAATACGACCCAATCAATTACATGAAGAAACCTCTAGGTC CACCACCTCCATCTTACACGTGTTTCCGTTGTGGTAAACCTGGACATTATATTAAGAATTGCCCAACAAATGGGGATAAAAACTTTGAATCTGGTCCTAG GATTAAAAAGAGCACTGGAATTCCCAGAAGTTTCATGATGGAAGTGAAAGATCCTAATATGAAAGGTGCAATGCTTACCAACACTGGAAAATATGCAATA CCAACTATAGATGCAGAAGCATATGCAATTGGGAAGAAAGAGAAACCTCCCTTCTTACCAGAGGAGCCATCTTCTTCCTCAGAAGAAGATGATCCTATCC CAGATGAATTGTTGTGTCTCATCTGCAAGGATATTATGACTGATGCTGTTGTGATTCCCTGCTGTGGAAACAGTTACTGTGATGAATGTATAAGAACAGC ACTCCTGGAATCAGATGAGCACACATGTCCGACGTGTCATCAAAATGATGTTTCTCCTGATGCTTTAATTGCCAATAAATTTTTACGACAGGCTGTAAAT AACTTCAAAAATGAAACTGGCTATACAAAAAGACTACGAAAACAGTTACCTCCTCCACCACCCCCAATACCACCTCCGAGACCACTGATTCAGAGGAACC TACAACCTCTGATGAGATCTCCGATATCAAGACAACAAGATCCTCTTATGATTCCAGTGACATCTTCATCAACTCACCCAGCTCCGTCTATATCTTCATT AACTTCTAATCAGTCTTCCTTGGCCCCTCCTGTGTCTGGAAATCCGTCTTCTGCTCCAGCTCCTGTACCTGATATAACTGCAACAGTATCCATATCAGTT CATTCAGAAAAATCAGATGGACCTTTTCGGGATTCTGATAATAAAATATTGCCAGCTGCAGCTCTTGCATCAGAGCACTCAAAGGGAACCTCCTCAATTG CAATTACCGCTCTTATGGAAGAGAAGGGTTACCAGGTGCCTGTTCTTGGAACCCCATCTTTGCTTGGACAGTCATTATTGCATGGACAGTTGATCCCCAC AACTGGTCCAGTAAGAATAAATACTGCTCGTCCAGGTGGTGGTCGACCAGGCTGGGAACATTCCAACAAACTTGGCTATCTGGTTTCTCCACCACAACAA ATTAGAAGAGGGGAGAGGAGCTGCTACAGAAGTATAAACCGTGGGCGACACCACAGCGAAAGATCACAGAGGACTCAAGGCCCGTCACTACCAGCAACTC CAGTCTTTGTACCTGTTCCACCACCTCCTTTGTATCCGCCTCCTCCCCATACACTTCCTCTCCCTCCGGGTGTTCCTCCTCCACAGTTTTCTCCTCAGTT TCCTCCTGGCCAGCCACCACCCGCTGGGTATAGTGTCCCTCCTCCAGGGTTTCCTCCAGCTCCTGCCAATTTATCAACACCTTGGGTATCATCAGGAGTG CAGACAGCTCATTCAAATACCATCCCAACAACACAAGCACCACCTTTGTCCAGGGAAGAATTCTATAGAGAGCAGCGACGACTAAAAGAAGAGTCTAAAT CTCCCTATAGTGGTTCTTCGTATTCAAGAAGTTCATATACTTATTCTAAATCAAGATCTGGTTCAACACGTTCACGCTCTTATTCTCGATCATTCAGCCG CTCACATTCTCGTTCCTATTCACGGTCACCTCCATACCCCAGAAGAGGCAGAGGCAAGAGCCGCAATTACCGTTCACGGTCTAGATCTCATGGATATCAT CGATCTAGGTCAAGGTCACCCCCTTACAGACGCTATCATTCACGATCAAGATCTCCTCAAGCGTTTAGGGGACAGTCTCCTAATAAACGTAATGTACCTC AAGGGGAAACAGAACGTGAATATTTTAATAGATACAGAGAAGTTCCACCACCATATGACATGAAAGCATATTATGGGAGAAGTGTTGACTTTAGAGACCC ATTTGAAAAAGAACGCTACCGAGAATGGGAGAGAAAATATAGAGAGTGGTATGAAAAATATTATAAAGGTTATGCTGCTGGAGCACAGCCTAGACCCTCA GCAAATAGAGAGAACTTTTCTCCAGAGAGATTTTTGCCACTTAACATCAGGAATTCTCCCTTCACAAGAGGCCGCAGAGAAGACTATGTTGGTGGGCAAA GTCATAGAAGTCGAAACATAGGTAGCAACTATCCAGAAAAGCTTTCAGCAAGAGATGGTCACAATCAGAAGGATAATACAAAGTCAAAAGAGAAGGAGAG TGAAAACGCTCCAGGAGATGGTAAAGGAAATAAGCATAAGAAACACAGAAAAAGAAGAAAAGGGGAGGAAAGTGAGGGTTTTCTGAACCCAGAGTTATTA GAGACTTCTAGGAAATCAAGAGAACCTACAGGTGTTGAAGAAAATAAAACAGACTCATTGTTTGTTCTCCCAAGTAGAGATGATGCCACACCTGTTAGAG ATGAACCAATGGATGCAGAATCAATCACTTTTAAATCAGTGTCTGAAAAAGACAAGAGAGAAAGGGATAAACCAAAAGCAAAGGGTGATAAAACCAAACG GAAGAATGATGGATCTGCTGTGTCCAAAAAAGAAAATATTGTAAAACCTGCTAAAGGACCCCAAGAAAAAGTAGATGGAGAACGTGAGAGATCTCCTCGA TCTGAACCTCCAATTAAAAAAGCCAAAGAGGAGACTCCGAAGACTGACAATACTAAATCATCATCTTCCTCTCAGAAGGATGAAAAAATCACTGGAACCC CCAGAAAAGCTCACTCTAAATCAGCAAAAGAACACCAAGAAACAAAACCAGTCAAAGAGGAAAAAGTGAAGAAGGACTATTCCAAAGATGTCAAATCAGA AAAGCTAACAACTAAGGAAGAAAAGGCCAAGAAGCCTAATGAGAAAAACAAACCACTTGATAATAAGGGAGAAAAAAGAAAAAGAAAAACTGAAGAAAAA GGCGTAGATAAAGATTTTGAGTCTTCTTCAATGAAAATCTCGAAACTAGAAGTGACTGAAATAGTGAAACCATCACCAAAGCGCAAAATGGAACCTGATA CTGAAAAAATGGATAGGACCCCTGAAAAGGACAAAATTTCTTTAAGTGCGCCAGCCAAAAAAATCAAACTCAACAGAGAAACTGGGAAGAAAATTGGAAG TACAGAAAATATATCAAACACAAAAGAACCCTCTGAAAAATTGGAGTCAACATCTAGCAAAGTTAAACAAGAAAAAGTCAAAGGAAAGGTCAGACGAAAA GTGACTGGAACTGAAGGATCCAGCTCAACTCTGGTGGATTACACCAGTACGAGCTCAACTGGAGGCAGTCCTGTGCGGAAATCTGAAGAAAAAACAGATA CAAAGCGAACTGTGATTAAAACGATGGAAGAATATAATAATGACAATACCGCGCCAGCTGAAGATGTTATCATTATGATTCAGGTTCCTCAATCCAAATG GGATAAAGATGACTTTGAATCTGAAGAAGAAGATGTTAAATCCACACAGCCTATATCAAGTGTAGGAAAACCTGCTAGTGTTATAAAAAATGTTAGTACA AAGCCATCAAATATAGTCAAGTATCCTGAGAAAGAAAGTGAGCCATCCGAGAAAATTCAGAAATTCACCAAGGACGTGAGCCATGAAATCATACAACATG AGGTTAAAAGTTCAAAAAACTCTGCATCTAGTGAAAAAGGGAAAACCAAAGATCGAGATTATTCAGTGTTGGAAAAGGAGAACCCTGAAAAGAGGAAGAA CAGCACTCAGCCAGAGAAAGAGAGTAATTTGGACCGTCTGAATGAACAAGGAAATTTTAAAAGTCTGTCTCAATCTTCCAAAGAGGCTAGAACGTCAGAT AAACATGATTCCACTCGTGCTTCCTCAAATAAAGACTTCACTCCCAATAGAGACAAAAAAACTGACTATGACACCAGAGAGTATTCAAGTTCCAAACGTA GAGATGAAAAGAATGAATTAACAAGACGAAAAGACTCTCCTTCTCGGAATAAAGATTCTGCATCTGGACAGAAAAATAAACCAAGGGAAGAGAGAGATTT GCCTAAAAAAGGAACAGGAGATTCCAAAAAAAGTAATTCTAGTCCCTCAAGAGACAGAAAACCTCATGATCACAAAGCCACTTATGATACTAAACGGCCA AATGAAGAGACAAAATCTGTAGATAAAAATCCTTGTAAGGATCGTGAGAAGCATGTATTAGAAGCAAGGAACAATAAAGAGTCAAGTGGCAATAAACTAC TTTATATACTTAACCCACCAGAGACACAGGTTGAAAAAGAGCAAATTACTGGGCAAATTGACAAGAGTACTGTCAAGCCTAAACCCCAGTTAAGTCATTC CTCTAGACTTTCCTCTGACTTAACTAGAGAAACTGATGAAGCTGCTTTTGAACCAGACTATAATGAAAGTGACAGTGAAAGTAATGTTTCTGTAAAAGAA GAGGAATCTTCAGGAAACATTTCTAAGGACCTGAAAGATAAAATAGTGGAGAAAGCAAAAGAGAGCCTGGACACAGCAGCAGTTGTCCAGGTGGGCATAA GCAGGAATCAGAGCCACAGCAGCCCCAGCGTCAGCCCCAGCAGAAGCCACAGTCCTTCTGGAAGCCAGACCCGAAGCCACAGTAGCAGTGCCAGCTCAGC AGAAAGTCAGGACAGCAAGAAGAAGAAGAAAAAGAAGGAAAAGAAAAAACACAAGAAACATAAAAAGCATAAGAAGCATAAGAAACATGCAGGCACTGAA GTGGAATTGGAAAAAAGCCAAAAACACAAACACAAGAAAAAGAAGTCAAAGAAGAACAAAGATAAAGAGAAGGAGAAGGAGAAAGATGACCAAAAAGTGA AATCTGTCACTGTGTAAAAAGACAGATTTTTTAAATTGACTTAATTACTAAGTCATCTGTATTAAATTTTGTTATAATGTAAAGAGATTCAAGCCTTGTA AATAATGACATGGAAGACCCTGTGCTGCACTTAAAATATTGCTGCTTGATTATTTGATTTTTACATCAGAGCTTTATAACACGAACTTTTGTACAGAATT GTGAGTTGTGACCATGTAACATGAGAGGTTTTGCTAGGGCCTATTATTTTTAACCACCATTAATTAGTTGGGGTGGAGTTTACTGTAATGTGAAATTTTC ACATTTGAATTTTTTAATTGCCTGGCAAAAGCTGATATAAGTTCTAAAATATCAGCAGAATGATTTGCTGAATTCATTACAACCCTGTTATGTCACTTTT TGATTACAATAAAAGTTTTCAGTAAACTTTTCAAA

refseq_RBBP6.F2 (forward primer)
refseq_RBBP6.R2 (reverse primer)
Single exon skipping

Frame 0

ARPRPP*YLAWRCRRRSVRAPERQGANTKREPE KP*PLPSSLRACSRGSGPQGDGNERRAKRGGSGE KKRQGASAVSPGSAEATRPPAGARGGEEVLRGL AEA*RRLCVRGGGGGGGRRSRGRPAGRPLLRRP RVFGLGRGAARGLRGAGARGLCAVGAWAWAWGS* RRSSGSQEEA*GRSWTPGLGPLPSTFSRGLGHP NPRRERPAGRCGRAMDP*PRGVARTLNVWTDRY *LHRQSPRLCRPLSMSEGDPAG*HCARWRILDFP SSPSSSSSSPMK*F*VSGGLWIIVLTNPCLWLG GI*SEALGSFGVFECFVCTYFALKVYKYTYIES VHVSSLNLRNPLAPCPVCIINFPLNSTMIPSPLM GSTSPSAT*RSRLWGERS*KLPTATCRSPMRRR KKNILMIML*FLRILL*LLEEFLLEVLNLQARH ML*VELNQRWQLQKQLMTLPRLFLWPSLQRLPIW LKPMLLKKIKLKQ*CRNLAMNTTQSIT*RNL*V HHLHLTRVSVVVNLDIILRIAQQMGIKTLNLVL GLKRALEFPEVS*WK*KILI*KVQCLPTLENMQY QL*MQKHMQLGRKRNLPSYQRSHLLPQKKMILS QMNCCVSSARIL*LMLL*FPAVETVTVMNV*EQ HSWNQMSTHVRRVIKMMFLLML*LPINFYDRL*I TSKMKLAIQKDYENSYLLHHPQYHLRDH*FRGT YNL**DLRYQDNKILL*FQ*HLHQLTQLRLYLH *LLISLPWPLLCLEIRLLLQLLYLI*LQQYPYQF IQKNQMDLFGILIIKYCQLQLLHQSTQREPPQL QLPLLWKRRVTRCLFLEPHLCLDSHYCMDS*SP QLVQ*E*ILLVQVVVDQAGNIPTNLAIWFLHHNK LEEGRGAATEV*TVGDTTAKDHRGLKARHYQQL QSLYLFHHLLCIRLLPIHFLSLRVFLLHSFLLS FLLASHHPLGIVSLLQGFLQLLPIYQHLGYHQEC RQLIQIPSQQHKHHLCPGKNSIESSDD*KKSLN LPIVVLRIQEVHILILNQDLVQHVHALILDHSA AHILVPIHGHLHTPEEAEARAAITVHGLDLMDII DLGQGHPLTDAIIHDQDLLKRLGDSLLINVMYL KGKQNVNILIDTEKFHHHMT*KHIMGEVLTLET HLKKNATENGRENIESGMKNIIKVMLLEHSLDPQ QIERTFLQRDFCHLTSGILPSQEAAEKTMLVGK VIEVET*VATIQKSFQQEMVTIRRIIQSQKRRR VKTLQEMVKEISIRNTEKEEKGRKVRVF*TQSY* RLLGNQENLQVLKKIKQTHCLFSQVEMMPHLLE MNQWMQNQSLLNQCLKKTREKGINQKQRVIKPN GRMMDLLCPKKKIL*NLLKDPKKK*MENVRDLLD LNLQLKKPKRRLRRLTILNHHLPLRRMKKSLEP PEKLTLNQQKNTKKQNQSKRKK*RRTIPKMSNQ KS*QLRKKRPRSLMRKTNHLIIREKKEKEKLKKK A*IKILSLLQ*KSRN*K*LK**NHHQSAKWNLI LKKWIGPLKRTKFL*VRQPKKSNSTEKLGRKLE VQKIYQTQKNPLKNWSQHLAKLNKKKSKERSDEK *LELKDPAQLWWITPVRAQLEAVLCGNLKKKQI QSEL*LKRWKNIIMTIPRQLKMLSL*FRFLNPN GIKMTLNLKKKMLNPHSLYQV*ENLLVL*KMLVQ SHQI*SSILRKKVSHPRKFRNSPRT*AMKSYNM RLKVQKTLHLVKKGKPKIEIIQCWKRRTLKRGR TALSQRKRVIWTV*MNKEILKVCLNLPKRLERQI NMIPLVLPQIKTSLPIETKKLTMTPESIQVPNV EMKRMN*QDEKTLLLGIKILHLDRKINQGKREI CLKKEQEIPKKVILVPQETENLMITKPLMILNGQ MKRQNL*IKILVRIVRSMY*KQGTIKSQVAINY FIYLTHQRHRLKKSKLLGKLTRVLSSLNPS*VI PLDFPLT*LEKLMKLLLNQTIMKVTVKVMFL*KK RNLQETFLRT*KIK*WRKQKRAWTQQQLSRWA* AGIRATAAPASAPAEATVLLEARPEATVAVPAQ QKVRTARRRRKRRKRKNTRNIKSIRSIRNMQALK WNWKKAKNTNTRKRSQRRTKIKRRRRRKMTKK* NLSLCKKTDFLN*LNY*VICIKFCYNVKRFKPC K**HGRPCAALKILLLDYLIFTSELYNTNFCTEL *VVTM*HERFC*GLLFLTTIN*LGWSLL*CEIF TFEFFNCLAKADISSKISAE*FAEFITTLLCHF LITIKVFSKLFK

Frame 1

PGRVRHSTWLGGVAAAR*EPPSGRGPTQKGSRR SPSRCPAACGRVLAVPGLKATETKGERSAEDPA RRSVREPRRCPRGPPKPPGRRLGPGVVRKCSEAS PRPSAGFVSEAAAAAGGGGAGGGLREGLSSADR AFSA*AVGPLVASGEQAPGVCVRWGPGPGPGEA DAGRPEARRRREAARGLRA*ALSPQPSPGAWVTP IHGERDPPGGAAALWTPDPVGSLGLLTCGLTAT DCTANPPVSAGPLA*ARGTQPGDIVPVGGFSIS PLPRPRPPPPP*SDSEYRGVSGLLF*RTPACGWG VFNLRP*GPSVSLSVLCVHILLLKFINIRILRV STSPR*TLGIPWHHVLCAL*IFL*TQL*YRHL* WAPHLPLRLKEADYGEREAESCRLRPADHQCADE RRIY***CSDS*EFFCNC*KNSYWRC*IYKQDI CYKSN*TSDGNYKSN**LFRVYFSGPAYKDCQS G*SQCF*RR*N*SNDVAIWP*IRPNQLHEETSRS TTSILHVFPLW*TWTLY*ELPNKWG*KL*IWS* D*KEHWNSQKFHDGSERS*YERCNAYQHWKICN TNYRCRSICNWEERETSLLTRGAIFFLRRR*SYP R*IVVSHLQGYYD*CCCDSLLWKQLL**MYKNS TPGIR*AHMSDVSSK*CFS*CFNCQ*IFTTGCK *LQK*NWLYKKTTKTVTSSTTPNTTSETTDSEEP TTSDEISDIKTTRSSYDSSDIFINSPSSVYIFI NF*SVFLGPSCVWKSVFCSSSCT*YNCNSIHIS SFRKIRWTFSGF***NIASCSSCIRALKGNLLNC NYRSYGREGLPGACSWNPIFAWTVIIAWTVDPH NWSSKNKYCSSRWWSTRLGTFQQTWLSGFSTTT N*KRGEELLQKYKPWATPQRKITEDSRPVTTSNS SLCTCSTTSFVSASSPYTSSPSGCSSSTVFSSV SSWPATTRWV*CPSSRVSSSSCQFINTLGIIRS ADSSFKYHPNNTSTTFVQGRIL*RAATTKRRV*I SL*WFFVFKKFIYLF*IKIWFNTFTLLFSIIQP LTFSFLFTVTSIPQKRQRQEPQLPFTV*ISWIS SI*VKVTPLQTLSFTIKISSSV*GTVS**T*CTS RGNRT*IF**IQRSSTTI*HESILWEKC*L*RP I*KRTLPRMGEKI*RVV*KIL*RLCCWSTA*TL SK*RELFSREIFAT*HQEFSLHKRPQRRLCWWAK S*KSKHR*QLSRKAFSKRWSQSEG*YKVKREGE *KRSRRW*RK*A*ETQKKKKRGGK*GFSEPRVI RDF*EIKRTYRC*RK*NRLIVCSPK*R*CHTC*R *TNGCRINHF*ISV*KRQERKG*TKSKG**NQT EE*WICCVQKRKYCKTC*RTPRKSRWRT*EISS I*TSN*KSQRGDSED*QY*IIIFLSEG*KNHWNP QKSSL*ISKRTPRNKTSQRGKSEEGLFQRCQIR KANN*GRKGQEA**EKQTT***GRKKKKKN*RK RRR*RF*VFFNENLETRSD*NSETITKAQNGT*Y *KNG*DP*KGQNFFKCASQKNQTQQRNWEENWK YRKYIKHKRTL*KIGVNI*QS*TRKSQRKGQTK SDWN*RIQLNSGGLHQYELNWRQSCAEI*RKNRY KANCD*NDGRI***QYRAS*RCYHYDSGSSIQM G*R*L*I*RRRC*IHTAYIKCRKTC*CYKKC*Y KAIKYSQVS*ERK*AIRENSEIHQGREP*NHTT* G*KFKKLCI**KRENQRSRLFSVGKGEP*KEEE QHSARERE*FGPSE*TRKF*KSVSIFQRG*NVR *T*FHSCFLK*RLHSQ*RQKN*L*HQRVFKFQT* R*KE*INKTKRLSFSE*RFCIWTEK*TKGRERF A*KRNRRFQKK*F*SLKRQKTS*SQSHL*Y*TA K*RDKICR*KSL*GS*EACIRSKEQ*RVKWQ*TT LYT*PTRDTG*KRANYWAN*QEYCQA*TPVKSF L*TFL*LN*RN**SCF*TRL**K*Q*K*CFCKR RGIFRKHF*GPER*NSGESKREPGHSSSCPGGHK QESEPQQPQRQPQQKPQSFWKPDPKPQ*QCQLS RKSGQQEEEEKEGKEKTQET*KA*EA*ETCRH* SGIGKKPKTQTQEKEVKEEQR*REGEGER*PKSE ICHCVKRQIF*IDLITKSSVLNFVIM*RDSSLV NNDMEDPVLHLKYCCLII*FLHQSFITRTFVQN CEL*PCNMRGFARAYYF*PPLISWGGVYCNVKFS HLNFLIAWQKLI*VLKYQQNDLLNSLQPCYVTF *LQ*KFSVNFS

Frame 2

QAASAIVPGLEVSPPLGESPRAAGGQHKKGAGE ALAAAQQLAGVFSRFRASRRRKRKASEARRIRR EEASGSLGGVPGVRRSHPAAGWGPGW*GSAPRP RRGLAPALCPRRRRRRGEAEPGAACGKASPPPTA RFRPRPWGRSWPPGSRRQGFVCGGGLGLGLGKL TPVVRKPGGGVRPLVDSGPRPSPLNLLPGPGSP QSTERETRREVRPRYGPLTPWGRSDS*RVD*PLL TAPPIPPSLPAP*HERGGPSRVTLCPLADSRFP LFPVLVLLLPHEVILSIGGSLDYCSDEPLLVVG GYLI*GLRVLRCL*VFCVYIFCS*SL*IYVY*EC PRLLAEP*ESLGTMSCVHYKFSSKLNYDTVTFD GLHISLCDLKKQIMGREKLKAADCDLQITNAQT KEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTY VISRTEPAMATTKAIDDSSASISLAQLTKTANL AEANASEEDKIKAMMSQSGHEYDPINYMKKPLG PPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPR IKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAI PTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPI PDELLCLICKDIMTDAVVIPCCGNSYCDECIRTA LLESDEHTCPTCHQNDVSPDALIANKFLRQAVN NFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRN LQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSL TSNQSSLAPPVSGNPSSAPAPVPDITATVSISV HSEKSDGPFRDSDNKILPAAALASEHSKGTSSI AITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPT TGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQ IRRGERSCYRSINRGRHHSERSQRTQGPSLPAT PVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQF PPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGV QTAHSNTIPTTQAPPLSREEFYREQRRLKEESK SPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSR SHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYH RSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVP QGETEREYFNRYREVPPPYDMKAYYGRSVDFRDP FEKERYREWERKYREWYEKYYKGYAAGAQPRPS ANRENFSPERFLPLNIRNSPFTRGRREDYVGGQ SHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKES ENAPGDGKGNKHKKHRKRRKGEESEGFLNPELL ETSRKSREPTGVEENKTDSLFVLPSRDDATPVR DEPMDAESITFKSVSEKDKRERDKPKAKGDKTKR KNDGSAVSKKENIVKPAKGPQEKVDGERERSPR SEPPIKKAKEETPKTDNTKSSSSSQKDEKITGT PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE KLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPD TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS TENISNTKEPSEKLESTSSKVKQEKVKGKVRRK VTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKW DKDDFESEEEDVKSTQPISSVGKPASVIKNVST KPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH EVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN STQPEKESNLDRLNEQGNFKSLSQSSKEARTSD KHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR RDEKNELTRRKDSPSRNKDSASGQKNKPREERDL PKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP NEETKSVDKNPCKDREKHVLEARNNKESSGNKL LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS SRLSSDLTRETDEAAFEPDYNESDSESNVSVKE EESSGNISKDLKDKIVEKAKESLDTAAVVQVGI SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSA ESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTE VELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV KSVTV*KDRFFKLT*LLSHLY*ILL*CKEIQAL* IMTWKTLCCT*NIAA*LFDFYIRAL*HELLYRI VSCDHVT*EVLLGPIIFNHH*LVGVEFTVM*NF HI*IF*LPGKS*YKF*NISRMIC*IHYNPVMSLF DYNKSFQ*TFQ

Sequence NM_006910

GCCAGGCCGCGTCCGCCATAGTACCTGGCTTGGAGGTGTCGCCGCCGCTCGGTGAGAGCCCCCGAGCGGCAGGGGGCCAACACAAAAAGGGAGCCGGAGA AGCCCTAGCCGCTGCCCAGCAGCTTGCGGGCGTGTTCTCGCGGTTCCGGGCCTCAAGGCGACGGAAACGAAAGGCGAGCGAAGCGCGGAGGATCCGGCGA GAAGAAGCGTCAGGGAGCCTCGGCGGTGTCCCCGGGGTCCGCCGAAGCCACCCGGCCGCCGGCTGGGGCCCGGGGTGGTGAGGAAGTGCTCCGAGGCCTC GCCGAGGCCTAGCGCCGGCTTTGTGTCCGAGGCGGCGGCGGCGGCGGGGGGAGGCGGAGCCGGGGGCGGCCTGCGGGAAGGCCTCTCCTCCGCCGACCGC GCGTTTTCGGCCTAGGCCGTGGGGCCGCTCGTGGCCTCCGGGGAGCAGGCGCCAGGGGTTTGTGTGCGGTGGGGGCCTGGGCCTGGGCCTGGGGAAGCTG ACGCCGGTCGTCCGGAAGCCAGGAGGAGGCGTGAGGCCGCTCGTGGACTCCGGGCCTAGGCCCTCTCCCCTCAACCTTCTCCCGGGGCCTGGGTCACCCC AATCCACGGAGAGAGAGACCCGCCGGGAGGTGCGGCCGCGCTATGGACCCCTGACCCCGTGGGGTCGCTCGGACTCTTAACGTGTGGACTGACCGCTACT GACTGCACCGCCAATCCCCCCGTCTCTGCCGGCCCCTTAGCATGAGCGAGGGGGACCCAGCCGGGTGACATTGTGCCCGTTGGCGGATTCTCGATTTCCC CTCTTCCCCGTCCTCGTCCTCCTCCTCCCCCATGAAGTGATTCTGAGTATCGGGGGGTCTCTGGATTATTGTTCTGACGAACCCCTGCTTGTGGTTGGGG GGTATTTAATCTGAGGCCTTAGGGTCCTTCGGTGTCTTTGAGTGTTTTGTGTGTACATATTTTGCTCTTAAAGTTTATAAATATACGTATATTGAGAGTG TCCACGTCTCCTCGCTGAACCTTAGGAATCCCTTGGCACCATGTCCTGTGTGCATTATAAATTTTCCTCTAAACTCAACTATGATACCGTCACCTTTGAT GGGCTCCACATCTCCCTCTGCGACTTAAAGAAGCAGATTATGGGGAGAGAGAAGCTGAAAGCTGCCGACTGCGACCTGCAGATCACCAATGCGCAGACGA AAGAAGAATATACTGATGATAATGCTCTGATTCCTAAGAATTCTTCTGTAATTGTTAGAAGAATTCCTATTGGAGGTGTTAAATCTACAAGCAAGACATA TGTTATAAGTCGAACTGAACCAGCGATGGCAACTACAAAAGCAATTGATGACTCTTCCGCGTCTATTTCTCTGGCCCAGCTTACAAAGACTGCCAATCTG GCTGAAGCCAATGCTTCTGAAGAAGATAAAATTAAAGCAATGATGTCGCAATCTGGCCATGAATACGACCCAATCAATTACATGAAGAAACCTCTAGGTC CACCACCTCCATCTTACACGTGTTTCCGTTGTGGTAAACCTGGACATTATATTAAGAATTGCCCAACAAATGGGGATAAAAACTTTGAATCTGGTCCTAG GATTAAAAAGAGCACTGGAATTCCCAGAAGTTTCATGATGGAAGTGAAAGATCCTAATATGAAAGGTGCAATGCTTACCAACACTGGAAAATATGCAATA CCAACTATAGATGCAGAAGCATATGCAATTGGGAAGAAAGAGAAACCTCCCTTCTTACCAGAGGAGCCATCTTCTTCCTCAGAAGAAGATGATCCTATCC CAGATGAATTGTTGTGTCTCATCTGCAAGGATATTATGACTGATGCTGTTGTGATTCCCTGCTGTGGAAACAGTTACTGTGATGAATGTATAAGAACAGC ACTCCTGGAATCAGATGAGCACACATGTCCGACGTGTCATCAAAATGATGTTTCTCCTGATGCTTTAATTGCCAATAAATTTTTACGACAGGCTGTAAAT AACTTCAAAAATGAAACTGGCTATACAAAAAGACTACGAAAACAGTTACCTCCTCCACCACCCCCAATACCACCTCCGAGACCACTGATTCAGAGGAACC TACAACCTCTGATGAGATCTCCGATATCAAGACAACAAGATCCTCTTATGATTCCAGTGACATCTTCATCAACTCACCCAGCTCCGTCTATATCTTCATT AACTTCTAATCAGTCTTCCTTGGCCCCTCCTGTGTCTGGAAATCCGTCTTCTGCTCCAGCTCCTGTACCTGATATAACTGCAACAGTATCCATATCAGTT CATTCAGAAAAATCAGATGGACCTTTTCGGGATTCTGATAATAAAATATTGCCAGCTGCAGCTCTTGCATCAGAGCACTCAAAGGGAACCTCCTCAATTG CAATTACCGCTCTTATGGAAGAGAAGGGTTACCAGGTGCCTGTTCTTGGAACCCCATCTTTGCTTGGACAGTCATTATTGCATGGACAGTTGATCCCCAC AACTGGTCCAGTAAGAATAAATACTGCTCGTCCAGGTGGTGGTCGACCAGGCTGGGAACATTCCAACAAACTTGGCTATCTGGTTTCTCCACCACAACAA ATTAGAAGAGGGGAGAGGAGCTGCTACAGAAGTATAAACCGTGGGCGACACCACAGCGAAAGATCACAGAGGACTCAAGGCCCGTCACTACCAGCAACTC CAGTCTTTGTACCTGTTCCACCACCTCCTTTGTATCCGCCTCCTCCCCATACACTTCCTCTCCCTCCGGGTGTTCCTCCTCCACAGTTTTCTCCTCAGTT TCCTCCTGGCCAGCCACCACCCGCTGGGTATAGTGTCCCTCCTCCAGGGTTTCCTCCAGCTCCTGCCAATTTATCAACACCTTGGGTATCATCAGGAGTG CAGACAGCTCATTCAAATACCATCCCAACAACACAAGCACCACCTTTGTCCAGGGAAGAATTCTATAGAGAGCAGCGACGACTAAAAGAAGAGGAAAAGA AAAAGTCCAAGCTAGATGAGTTTACAAATGATTTTGCTAAGGAATTGATGGAATACAAAAAGATTCAAAAGGAGCGTAGGCGCTCATTTTCCAGGTCTAA ATCTCCCTATAGTGGTTCTTCGTATTCAAGAAGTTCATATACTTATTCTAAATCAAGATCTGGTTCAACACGTTCACGCTCTTATTCTCGATCATTCAGC CGCTCACATTCTCGTTCCTATTCACGGTCACCTCCATACCCCAGAAGAGGCAGAGGCAAGAGCCGCAATTACCGTTCACGGTCTAGATCTCATGGATATC ATCGATCTAGGTCAAGGTCACCCCCTTACAGACGCTATCATTCACGATCAAGATCTCCTCAAGCGTTTAGGGGACAGTCTCCTAATAAACGTAATGTACC TCAAGGGGAAACAGAACGTGAATATTTTAATAGATACAGAGAAGTTCCACCACCATATGACATGAAAGCATATTATGGGAGAAGTGTTGACTTTAGAGAC CCATTTGAAAAAGAACGCTACCGAGAATGGGAGAGAAAATATAGAGAGTGGTATGAAAAATATTATAAAGGTTATGCTGCTGGAGCACAGCCTAGACCCT CAGCAAATAGAGAGAACTTTTCTCCAGAGAGATTTTTGCCACTTAACATCAGGAATTCTCCCTTCACAAGAGGCCGCAGAGAAGACTATGTTGGTGGGCA AAGTCATAGAAGTCGAAACATAGGTAGCAACTATCCAGAAAAGCTTTCAGCAAGAGATGGTCACAATCAGAAGGATAATACAAAGTCAAAAGAGAAGGAG AGTGAAAACGCTCCAGGAGATGGTAAAGGAAATAAGCATAAGAAACACAGAAAAAGAAGAAAAGGGGAGGAAAGTGAGGGTTTTCTGAACCCAGAGTTAT TAGAGACTTCTAGGAAATCAAGAGAACCTACAGGTGTTGAAGAAAATAAAACAGACTCATTGTTTGTTCTCCCAAGTAGAGATGATGCCACACCTGTTAG AGATGAACCAATGGATGCAGAATCAATCACTTTTAAATCAGTGTCTGAAAAAGACAAGAGAGAAAGGGATAAACCAAAAGCAAAGGGTGATAAAACCAAA CGGAAGAATGATGGATCTGCTGTGTCCAAAAAAGAAAATATTGTAAAACCTGCTAAAGGACCCCAAGAAAAAGTAGATGGAGAACGTGAGAGATCTCCTC GATCTGAACCTCCAATTAAAAAAGCCAAAGAGGAGACTCCGAAGACTGACAATACTAAATCATCATCTTCCTCTCAGAAGGATGAAAAAATCACTGGAAC CCCCAGAAAAGCTCACTCTAAATCAGCAAAAGAACACCAAGAAACAAAACCAGTCAAAGAGGAAAAAGTGAAGAAGGACTATTCCAAAGATGTCAAATCA GAAAAGCTAACAACTAAGGAAGAAAAGGCCAAGAAGCCTAATGAGAAAAACAAACCACTTGATAATAAGGGAGAAAAAAGAAAAAGAAAAACTGAAGAAA AAGGCGTAGATAAAGATTTTGAGTCTTCTTCAATGAAAATCTCGAAACTAGAAGTGACTGAAATAGTGAAACCATCACCAAAGCGCAAAATGGAACCTGA TACTGAAAAAATGGATAGGACCCCTGAAAAGGACAAAATTTCTTTAAGTGCGCCAGCCAAAAAAATCAAACTCAACAGAGAAACTGGGAAGAAAATTGGA AGTACAGAAAATATATCAAACACAAAAGAACCCTCTGAAAAATTGGAGTCAACATCTAGCAAAGTTAAACAAGAAAAAGTCAAAGGAAAGGTCAGACGAA AAGTGACTGGAACTGAAGGATCCAGCTCAACTCTGGTGGATTACACCAGTACGAGCTCAACTGGAGGCAGTCCTGTGCGGAAATCTGAAGAAAAAACAGA TACAAAGCGAACTGTGATTAAAACGATGGAAGAATATAATAATGACAATACCGCGCCAGCTGAAGATGTTATCATTATGATTCAGGTTCCTCAATCCAAA TGGGATAAAGATGACTTTGAATCTGAAGAAGAAGATGTTAAATCCACACAGCCTATATCAAGTGTAGGAAAACCTGCTAGTGTTATAAAAAATGTTAGTA CAAAGCCATCAAATATAGTCAAGTATCCTGAGAAAGAAAGTGAGCCATCCGAGAAAATTCAGAAATTCACCAAGGACGTGAGCCATGAAATCATACAACA TGAGGTTAAAAGTTCAAAAAACTCTGCATCTAGTGAAAAAGGGAAAACCAAAGATCGAGATTATTCAGTGTTGGAAAAGGAGAACCCTGAAAAGAGGAAG AACAGCACTCAGCCAGAGAAAGAGAGTAATTTGGACCGTCTGAATGAACAAGGAAATTTTAAAAGTCTGTCTCAATCTTCCAAAGAGGCTAGAACGTCAG ATAAACATGATTCCACTCGTGCTTCCTCAAATAAAGACTTCACTCCCAATAGAGACAAAAAAACTGACTATGACACCAGAGAGTATTCAAGTTCCAAACG TAGAGATGAAAAGAATGAATTAACAAGACGAAAAGACTCTCCTTCTCGGAATAAAGATTCTGCATCTGGACAGAAAAATAAACCAAGGGAAGAGAGAGAT TTGCCTAAAAAAGGAACAGGAGATTCCAAAAAAAGTAATTCTAGTCCCTCAAGAGACAGAAAACCTCATGATCACAAAGCCACTTATGATACTAAACGGC CAAATGAAGAGACAAAATCTGTAGATAAAAATCCTTGTAAGGATCGTGAGAAGCATGTATTAGAAGCAAGGAACAATAAAGAGTCAAGTGGCAATAAACT ACTTTATATACTTAACCCACCAGAGACACAGGTTGAAAAAGAGCAAATTACTGGGCAAATTGACAAGAGTACTGTCAAGCCTAAACCCCAGTTAAGTCAT TCCTCTAGACTTTCCTCTGACTTAACTAGAGAAACTGATGAAGCTGCTTTTGAACCAGACTATAATGAAAGTGACAGTGAAAGTAATGTTTCTGTAAAAG AAGAGGAATCTTCAGGAAACATTTCTAAGGACCTGAAAGATAAAATAGTGGAGAAAGCAAAAGAGAGCCTGGACACAGCAGCAGTTGTCCAGGTGGGCAT AAGCAGGAATCAGAGCCACAGCAGCCCCAGCGTCAGCCCCAGCAGAAGCCACAGTCCTTCTGGAAGCCAGACCCGAAGCCACAGTAGCAGTGCCAGCTCA GCAGAAAGTCAGGACAGCAAGAAGAAGAAGAAAAAGAAGGAAAAGAAAAAACACAAGAAACATAAAAAGCATAAGAAGCATAAGAAACATGCAGGCACTG AAGTGGAATTGGAAAAAAGCCAAAAACACAAACACAAGAAAAAGAAGTCAAAGAAGAACAAAGATAAAGAGAAGGAGAAGGAGAAAGATGACCAAAAAGT GAAATCTGTCACTGTGTAAAAAGACAGATTTTTTAAATTGACTTAATTACTAAGTCATCTGTATTAAATTTTGTTATAATGTAAAGAGATTCAAGCCTTG TAAATAATGACATGGAAGACCCTGTGCTGCACTTAAAATATTGCTGCTTGATTATTTGATTTTTACATCAGAGCTTTATAACACGAACTTTTGTACAGAA TTGTGAGTTGTGACCATGTAACATGAGAGGTTTTGCTAGGGCCTATTATTTTTAACCACCATTAATTAGTTGGGGTGGAGTTTACTGTAATGTGAAATTT TCACATTTGAATTTTTTAATTGCCTGGCAAAAGCTGATATAAGTTCTAAAATATCAGCAGAATGATTTGCTGAATTCATTACAACCCTGTTATGTCACTT TTTGATTACAATAAAAGTTTTCAGTAAACTTTTCAAA

refseq_RBBP6.F2 (forward primer)
refseq_RBBP6.R2 (reverse primer)
Single exon skipping

Frame 0

ARPRPP*YLAWRCRRRSVRAPERQGANTKREPE KP*PLPSSLRACSRGSGPQGDGNERRAKRGGSGE KKRQGASAVSPGSAEATRPPAGARGGEEVLRGL AEA*RRLCVRGGGGGGGRRSRGRPAGRPLLRRP RVFGLGRGAARGLRGAGARGLCAVGAWAWAWGS* RRSSGSQEEA*GRSWTPGLGPLPSTFSRGLGHP NPRRERPAGRCGRAMDP*PRGVARTLNVWTDRY *LHRQSPRLCRPLSMSEGDPAG*HCARWRILDFP SSPSSSSSSPMK*F*VSGGLWIIVLTNPCLWLG GI*SEALGSFGVFECFVCTYFALKVYKYTYIES VHVSSLNLRNPLAPCPVCIINFPLNSTMIPSPLM GSTSPSAT*RSRLWGERS*KLPTATCRSPMRRR KKNILMIML*FLRILL*LLEEFLLEVLNLQARH ML*VELNQRWQLQKQLMTLPRLFLWPSLQRLPIW LKPMLLKKIKLKQ*CRNLAMNTTQSIT*RNL*V HHLHLTRVSVVVNLDIILRIAQQMGIKTLNLVL GLKRALEFPEVS*WK*KILI*KVQCLPTLENMQY QL*MQKHMQLGRKRNLPSYQRSHLLPQKKMILS QMNCCVSSARIL*LMLL*FPAVETVTVMNV*EQ HSWNQMSTHVRRVIKMMFLLML*LPINFYDRL*I TSKMKLAIQKDYENSYLLHHPQYHLRDH*FRGT YNL**DLRYQDNKILL*FQ*HLHQLTQLRLYLH *LLISLPWPLLCLEIRLLLQLLYLI*LQQYPYQF IQKNQMDLFGILIIKYCQLQLLHQSTQREPPQL QLPLLWKRRVTRCLFLEPHLCLDSHYCMDS*SP QLVQ*E*ILLVQVVVDQAGNIPTNLAIWFLHHNK LEEGRGAATEV*TVGDTTAKDHRGLKARHYQQL QSLYLFHHLLCIRLLPIHFLSLRVFLLHSFLLS FLLASHHPLGIVSLLQGFLQLLPIYQHLGYHQEC RQLIQIPSQQHKHHLCPGKNSIESSDD*KKRKR KSPS*MSLQMILLRN*WNTKRFKRSVGAHFPGL NLPIVVLRIQEVHILILNQDLVQHVHALILDHSA AHILVPIHGHLHTPEEAEARAAITVHGLDLMDI IDLGQGHPLTDAIIHDQDLLKRLGDSLLINVMY LKGKQNVNILIDTEKFHHHMT*KHIMGEVLTLET HLKKNATENGRENIESGMKNIIKVMLLEHSLDP QQIERTFLQRDFCHLTSGILPSQEAAEKTMLVG KVIEVET*VATIQKSFQQEMVTIRRIIQSQKRRR VKTLQEMVKEISIRNTEKEEKGRKVRVF*TQSY *RLLGNQENLQVLKKIKQTHCLFSQVEMMPHLL EMNQWMQNQSLLNQCLKKTREKGINQKQRVIKPN GRMMDLLCPKKKIL*NLLKDPKKK*MENVRDLL DLNLQLKKPKRRLRRLTILNHHLPLRRMKKSLE PPEKLTLNQQKNTKKQNQSKRKK*RRTIPKMSNQ KS*QLRKKRPRSLMRKTNHLIIREKKEKEKLKK KA*IKILSLLQ*KSRN*K*LK**NHHQSAKWNL ILKKWIGPLKRTKFL*VRQPKKSNSTEKLGRKLE VQKIYQTQKNPLKNWSQHLAKLNKKKSKERSDE K*LELKDPAQLWWITPVRAQLEAVLCGNLKKKQ IQSEL*LKRWKNIIMTIPRQLKMLSL*FRFLNPN GIKMTLNLKKKMLNPHSLYQV*ENLLVL*KMLV QSHQI*SSILRKKVSHPRKFRNSPRT*AMKSYN MRLKVQKTLHLVKKGKPKIEIIQCWKRRTLKRGR TALSQRKRVIWTV*MNKEILKVCLNLPKRLERQ INMIPLVLPQIKTSLPIETKKLTMTPESIQVPN VEMKRMN*QDEKTLLLGIKILHLDRKINQGKREI CLKKEQEIPKKVILVPQETENLMITKPLMILNG QMKRQNL*IKILVRIVRSMY*KQGTIKSQVAIN YFIYLTHQRHRLKKSKLLGKLTRVLSSLNPS*VI PLDFPLT*LEKLMKLLLNQTIMKVTVKVMFL*K KRNLQETFLRT*KIK*WRKQKRAWTQQQLSRWA *AGIRATAAPASAPAEATVLLEARPEATVAVPAQ QKVRTARRRRKRRKRKNTRNIKSIRSIRNMQAL KWNWKKAKNTNTRKRSQRRTKIKRRRRRKMTKK *NLSLCKKTDFLN*LNY*VICIKFCYNVKRFKPC K**HGRPCAALKILLLDYLIFTSELYNTNFCTE L*VVTM*HERFC*GLLFLTTIN*LGWSLL*CEI FTFEFFNCLAKADISSKISAE*FAEFITTLLCHF LITIKVFSKLFK

Frame 1

PGRVRHSTWLGGVAAAR*EPPSGRGPTQKGSRR SPSRCPAACGRVLAVPGLKATETKGERSAEDPA RRSVREPRRCPRGPPKPPGRRLGPGVVRKCSEAS PRPSAGFVSEAAAAAGGGGAGGGLREGLSSADR AFSA*AVGPLVASGEQAPGVCVRWGPGPGPGEA DAGRPEARRRREAARGLRA*ALSPQPSPGAWVTP IHGERDPPGGAAALWTPDPVGSLGLLTCGLTAT DCTANPPVSAGPLA*ARGTQPGDIVPVGGFSIS PLPRPRPPPPP*SDSEYRGVSGLLF*RTPACGWG VFNLRP*GPSVSLSVLCVHILLLKFINIRILRV STSPR*TLGIPWHHVLCAL*IFL*TQL*YRHL* WAPHLPLRLKEADYGEREAESCRLRPADHQCADE RRIY***CSDS*EFFCNC*KNSYWRC*IYKQDI CYKSN*TSDGNYKSN**LFRVYFSGPAYKDCQS G*SQCF*RR*N*SNDVAIWP*IRPNQLHEETSRS TTSILHVFPLW*TWTLY*ELPNKWG*KL*IWS* D*KEHWNSQKFHDGSERS*YERCNAYQHWKICN TNYRCRSICNWEERETSLLTRGAIFFLRRR*SYP R*IVVSHLQGYYD*CCCDSLLWKQLL**MYKNS TPGIR*AHMSDVSSK*CFS*CFNCQ*IFTTGCK *LQK*NWLYKKTTKTVTSSTTPNTTSETTDSEEP TTSDEISDIKTTRSSYDSSDIFINSPSSVYIFI NF*SVFLGPSCVWKSVFCSSSCT*YNCNSIHIS SFRKIRWTFSGF***NIASCSSCIRALKGNLLNC NYRSYGREGLPGACSWNPIFAWTVIIAWTVDPH NWSSKNKYCSSRWWSTRLGTFQQTWLSGFSTTT N*KRGEELLQKYKPWATPQRKITEDSRPVTTSNS SLCTCSTTSFVSASSPYTSSPSGCSSSTVFSSV SSWPATTRWV*CPSSRVSSSSCQFINTLGIIRS ADSSFKYHPNNTSTTFVQGRIL*RAATTKRRGKE KVQAR*VYK*FC*GIDGIQKDSKGA*ALIFQV* ISL*WFFVFKKFIYLF*IKIWFNTFTLLFSIIQ PLTFSFLFTVTSIPQKRQRQEPQLPFTV*ISWIS SI*VKVTPLQTLSFTIKISSSV*GTVS**T*CT SRGNRT*IF**IQRSSTTI*HESILWEKC*L*R PI*KRTLPRMGEKI*RVV*KIL*RLCCWSTA*TL SK*RELFSREIFAT*HQEFSLHKRPQRRLCWWA KS*KSKHR*QLSRKAFSKRWSQSEG*YKVKREG E*KRSRRW*RK*A*ETQKKKKRGGK*GFSEPRVI RDF*EIKRTYRC*RK*NRLIVCSPK*R*CHTC* R*TNGCRINHF*ISV*KRQERKG*TKSKG**NQ TEE*WICCVQKRKYCKTC*RTPRKSRWRT*EISS I*TSN*KSQRGDSED*QY*IIIFLSEG*KNHWN PQKSSL*ISKRTPRNKTSQRGKSEEGLFQRCQI RKANN*GRKGQEA**EKQTT***GRKKKKKN*RK RRR*RF*VFFNENLETRSD*NSETITKAQNGT* Y*KNG*DP*KGQNFFKCASQKNQTQQRNWEENW KYRKYIKHKRTL*KIGVNI*QS*TRKSQRKGQTK SDWN*RIQLNSGGLHQYELNWRQSCAEI*RKNR YKANCD*NDGRI***QYRAS*RCYHYDSGSSIQ MG*R*L*I*RRRC*IHTAYIKCRKTC*CYKKC*Y KAIKYSQVS*ERK*AIRENSEIHQGREP*NHTT *G*KFKKLCI**KRENQRSRLFSVGKGEP*KEE EQHSARERE*FGPSE*TRKF*KSVSIFQRG*NVR *T*FHSCFLK*RLHSQ*RQKN*L*HQRVFKFQT *R*KE*INKTKRLSFSE*RFCIWTEK*TKGRER FA*KRNRRFQKK*F*SLKRQKTS*SQSHL*Y*TA K*RDKICR*KSL*GS*EACIRSKEQ*RVKWQ*T TLYT*PTRDTG*KRANYWAN*QEYCQA*TPVKS FL*TFL*LN*RN**SCF*TRL**K*Q*K*CFCKR RGIFRKHF*GPER*NSGESKREPGHSSSCPGGH KQESEPQQPQRQPQQKPQSFWKPDPKPQ*QCQL SRKSGQQEEEEKEGKEKTQET*KA*EA*ETCRH* SGIGKKPKTQTQEKEVKEEQR*REGEGER*PKS EICHCVKRQIF*IDLITKSSVLNFVIM*RDSSL VNNDMEDPVLHLKYCCLII*FLHQSFITRTFVQN CEL*PCNMRGFARAYYF*PPLISWGGVYCNVKF SHLNFLIAWQKLI*VLKYQQNDLLNSLQPCYVT F*LQ*KFSVNFS

Frame 2

QAASAIVPGLEVSPPLGESPRAAGGQHKKGAGE ALAAAQQLAGVFSRFRASRRRKRKASEARRIRR EEASGSLGGVPGVRRSHPAAGWGPGW*GSAPRP RRGLAPALCPRRRRRRGEAEPGAACGKASPPPTA RFRPRPWGRSWPPGSRRQGFVCGGGLGLGLGKL TPVVRKPGGGVRPLVDSGPRPSPLNLLPGPGSP QSTERETRREVRPRYGPLTPWGRSDS*RVD*PLL TAPPIPPSLPAP*HERGGPSRVTLCPLADSRFP LFPVLVLLLPHEVILSIGGSLDYCSDEPLLVVG GYLI*GLRVLRCL*VFCVYIFCS*SL*IYVY*EC PRLLAEP*ESLGTMSCVHYKFSSKLNYDTVTFD GLHISLCDLKKQIMGREKLKAADCDLQITNAQT KEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTY VISRTEPAMATTKAIDDSSASISLAQLTKTANL AEANASEEDKIKAMMSQSGHEYDPINYMKKPLG PPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPR IKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAI PTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPI PDELLCLICKDIMTDAVVIPCCGNSYCDECIRTA LLESDEHTCPTCHQNDVSPDALIANKFLRQAVN NFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRN LQPLMRSPISRQQDPLMIPVTSSSTHPAPSISSL TSNQSSLAPPVSGNPSSAPAPVPDITATVSISV HSEKSDGPFRDSDNKILPAAALASEHSKGTSSI AITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPT TGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQ IRRGERSCYRSINRGRHHSERSQRTQGPSLPAT PVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQF PPGQPPPAGYSVPPPGFPPAPANLSTPWVSSGV QTAHSNTIPTTQAPPLSREEFYREQRRLKEEEK KKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSK SPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGY HRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVP QGETEREYFNRYREVPPPYDMKAYYGRSVDFRD PFEKERYREWERKYREWYEKYYKGYAAGAQPRP SANRENFSPERFLPLNIRNSPFTRGRREDYVGGQ SHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKE SENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL LETSRKSREPTGVEENKTDSLFVLPSRDDATPVR DEPMDAESITFKSVSEKDKRERDKPKAKGDKTK RKNDGSAVSKKENIVKPAKGPQEKVDGERERSP RSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGT PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKS EKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEE KGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPD TEKMDRTPEKDKISLSAPAKKIKLNRETGKKIG STENISNTKEPSEKLESTSSKVKQEKVKGKVRR KVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK WDKDDFESEEEDVKSTQPISSVGKPASVIKNVS TKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH EVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK NSTQPEKESNLDRLNEQGNFKSLSQSSKEARTS DKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR RDEKNELTRRKDSPSRNKDSASGQKNKPREERD LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR PNEETKSVDKNPCKDREKHVLEARNNKESSGNKL LYILNPPETQVEKEQITGQIDKSTVKPKPQLSH SSRLSSDLTRETDEAAFEPDYNESDSESNVSVK EEESSGNISKDLKDKIVEKAKESLDTAAVVQVGI SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGT EVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKV KSVTV*KDRFFKLT*LLSHLY*ILL*CKEIQAL *IMTWKTLCCT*NIAA*LFDFYIRAL*HELLYR IVSCDHVT*EVLLGPIIFNHH*LVGVEFTVM*NF HI*IF*LPGKS*YKF*NISRMIC*IHYNPVMSL FDYNKSFQ*TFQ