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Sequences

Sequence NM_020779

CAGGGCGACGGGAGCTTTCCGGAGCTGCTGGTACTCCCGATTGGAGACGTAGAACCGTTACTTGTCGAGGGCCTTAGCGGCCGCCGTGACCCTCTCGGGG ATCCCACGATGTTCTTCTACCTGAGCAAGAAAATTTCCATTCCCAATAACGTGAAGCTGCAGTGTGTATCCTGGAACAAGGAACAAGGGTTCATAGCATG CGGTGGTGAAGATGGATTACTGAAAGTTTTGAAATTAGAGACGCAGACAGATGATGCAAAATTGAGGGGCCTTGCAGCCCCCAGTAACCTTTCTATGAAT CAGACTCTTGAAGGTCATAGTGGTTCTGTTCAAGTTGTAACATGGAATGAGCAGTATCAGAAGTTGACTACCAGTGATGAAAACGGGCTTATCATTGTGT GGATGTTATATAAAGGCTCTTGGATTGAGGAGATGATCAACAATCGAAATAAATCAGTTGTTCGCAGTATGAGCTGGAATGCTGACGGACAGAAGATCTG CATTGTATATGAAGATGGGGCTGTGATAGTTGGTTCAGTGGATGGCAATCGTATTTGGGGAAAAGACCTGAAGGGTATACAGCTATCCCATGTAACATGG TCTGCGGACAGTAAAGTCTTACTTTTTGGAATGGCAAATGGGGAAATACACATTTACGATAATCAAGGAAATTTTATGATAAAAATGAAACTGAGTTGTT TGGTGAATGTCACTGGAGCTATCAGCATTGCTGGAATTCATTGGTACCATGGCACAGAAGGCTACGTGGAGCCTGATTGCCCTTGCCTTGCTGTTTGCTT TGATAATGGAAGATGCCAAATAATGAGACATGAGAATGACCAAAATCCCGTTTTGATTGACACTGGCATGTACGTAGTAGGCATCCAGTGGAACCACATG GGCAGCGTGTTAGCTGTGGCAGGCTTCCAGAAGGCAGCCATGCAGGACAAAGATGTGAACATTGTGCAGTTTTACACTCCGTTTGGTGAGCATCTGGGTA CTTTGAAAGTTCCTGGAAAGGAAATATCTGCACTATCTTGGGAAGGAGGTGGACTGAAAATTGCACTAGCTGTTGATTCCTTTATATATTTTGCAAACAT TCGACCTAATTATAAGTGGGGTTATTGCTCAAACACTGTAGTTTATGCATATACCAGACCTGATCGTCCAGAATATTGTGTTGTCTTCTGGGATACGAAA AACAATGAAAAATATGTTAAATATGTGAAGGGTCTCATTTCTATTACTACCTGTGGAGATTTCTGCATTTTGGCTACAAAAGCTGATGAAAATCATCCTC AGTTTGTACTAGTTCTTTGTAATTCTATTGGTACACCCTTGGATCCCAAATACATTGATATTGTACCATTGTTTGTTGCAATGACCAAAACCCATGTGAT AGCAGCCTCGAAAGAAGCATTTTATACCTGGCAATATCGTGTGGCAAAGAAGCTCACAGCATTGGAAATTAATCAGATCACACGGTCTCGAAAAGAAGGG AGAGAAAGAATTTATCATGTTGATGATACCCCTTCTGGATCAATGGATGGTGTGCTTGATTATAGTAAAACCATTCAAGGCACAAGGGATCCAATTTGTG CCATAACTGCATCAGATAAGATATTGATTGTGGGTCGTGAATCTGGCACCATTCAGAGATACAGTCTACCTAATGTTGGTTTGATTCAAAAATATTCCCT TAATTGTCGAGCCTACCAGTTATCCTTGAATTGCAACTCTAGCCGTCTTGCTATCATAGACATCTCAGGAGTTCTGACTTTCTTTGACTTGGATGCTCGA GTAACGGACAGTACGGGACAGCAAGTAGTTGGAGAGTTGTTAAAATTGGAACGAAGAGATGTCTGGGATATGAAGTGGGCCAAAGATAATCCTGATTTGT TTGCAATGATGGAGAAGACAAGAATGTATGTTTTCAGAAACTTGGATCCTGAGGAACCCATTCAGACCTCTGGATATATTTGTAATTTTGAGGATTTAGA AATTAAATCTGTTCTTTTGGATGAGATATTAAAGGATCCAGAACATCCAAACAAGGATTACCTAATTAACTTTGAGATTCGGTCTCTGCGAGATAGCCGA GCACTGATTGAGAAGGTTGGAATTAAAGATGCATCTCAGTTCATAGAGGACAATCCACACCCCCGACTTTGGCGCCTACTGGCTGAAGCAGCTCTTCAGA AACTGGATCTATACACTGCAGAGCAAGCATTTGTGCGCTGCAAAGATTACCAAGGCATTAAGTTTGTGAAGCGCTTGGGCAAACTACTGAGTGAGTCAAT GAAACAGGCTGAAGTTGTTGGCTACTTCGGCAGGTTTGAAGAGGCTGAAAGAACGTATCTCGAGATGGACAGAAGGGATCTTGCTATTGGCCTCCGGCTG AAATTGGGGGATTGGTTTAGAGTACTCCAGCTCCTGAAAACTGGATCTGGTGATGCAGATGACAGTCTCCTGGAACAAGCCAACAATGCCATTGGAGACT ACTTTGCTGATCGACAAAAGTGGTTGAATGCTGTACAATATTATGTACAAGGACGGAACCAGGAACGCTTAGCTGAATGTTACTATATGTTAGAGGATTA TGAAGGGTTAGAGAACCTTGCCATTTCACTTCCAGAAAACCACAAGTTACTTCCAGAAATAGCACAAATGTTTGTCAGAGTTGGAATGTGTGAACAAGCA GTGACTGCATTTTTGAAATGTAGTCAACCAAAGGCAGCAGTAGATACCTGCGTACATCTCAACCAATGGAACAAAGCTGTTGAATTGGCTAAAAATCATA GTATGAAAGAAATTGGATCTCTGTTAGCTAGGTATGCATCTCATTTACTGGAAAAGAATAAAACTCTTGATGCCATAGAACTCTATCGGAAAGCCAATTA CTTTTTTGATGCAGCTAAACTGATGTTTAAGATTGCAGATGAAGAGGCAAAGAAAGGAAGTAAACCTTTACGTGTCAAGAAGCTCTATGTACTGTCAGCC TTACTTATAGAGCAATACCATGAACAGATGAAGAATGCCCAGCGAGGAAAAGTTAAAGGAAAAAGTTCAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGG AAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGA GGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCACTCTGCGCA TGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTG CTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGC CACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTA TGCCATAGTCCAGTGGGATAAAGGAATGATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTT ATTTCTGTGAGTTTTGTATGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGT GAAATAATAAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATACCA TGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAAGCATGGGAGTGG GGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTCTCTATAGCCATATTTAATTAAA TAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTACAATCTGAATTGTTTCTAATAGCCCTATTCTTC TATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTTTCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAG ATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAACATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGA TTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAATTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAAT AATGTTCTCTGTTTATTTCTCATGAATTCCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACAT ATAGTAGAGGCAATACATAGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGT TCAGCATGTTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAGAG AAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGCCTCGCAAGCTAT TCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGCAATACACAGTGAGGAACAAGGA GAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAATCCTGGGTTTTGTAATGTTTTTATGTCCTGAC TCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTGGCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGA GGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTACACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTT TATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTGTCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCAT ACTTAGTGTATCATGAATATTTGGTATCTTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACA CATACACGCTCTATTAACTTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATA CCAGAATGGGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGGAC TTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCTGCCTGTCTGAAA GGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTTCCTGTCTCAGGAATCAGCTGAG AATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAGTTCTAGAATCACCTGTTGACTCCTCAGACTTC ACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGCCTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAG ATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGATATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCA TACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGCGCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGT ATCTATATCTGTGAAAGTTTTAATGATCTGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAA TCTAGTTGGTTTTATTCGACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAA AAACAATTACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATGTA CTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAAAATATTGAAATG ATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCACAAATGCTAATTTCATTATAAA TTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATGTAGTATTAAGTGAAAAAATACGAAAATAATAA ACATTGAAGAAAAAAA

refseq_WDR35.F1 (forward primer)
refseq_WDR35.R1 (reverse primer)
Single exon skipping

Frame 0

QGDGSFPELLVLPIGDVEPLLVEGLSGRRDPLG DPTMFFYLSKKISIPNNVKLQCVSWNKEQGFIAC GGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMN QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIV WMLYKGSWIEEMINNRNKSVVRSMSWNADGQKIC IVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTW SADSKVLLFGMANGEIHIYDNQGNFMIKMKLSC LVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCF DNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHM GSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLG TLKVPGKEISALSWEGGGLKIALAVDSFIYFANI RPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTK NNEKYVKYVKGLISITTCGDFCILATKADENHP QFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVI AASKEAFYTWQYRVAKKLTALEINQITRSRKEG RERIYHVDDTPSGSMDGVLDYSKTIQGTRDPIC AITASDKILIVGRESGTIQRYSLPNVGLIQKYSL NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDAR VTDSTGQQVVGELLKLERRDVWDMKWAKDNPDL FAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLE IKSVLLDEILKDPEHPNKDYLINFEIRSLRDSR ALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQ KLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESM KQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRL KLGDWFRVLQLLKTGSGDADDSLLEQANNAIGD YFADRQKWLNAVQYYVQGRNQERLAECYYMLEDY EGLENLAISLPENHKLLPEIAQMFVRVGMCEQA VTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNH SMKEIGSLLARYASHLLEKNKTLDAIELYRKANY FFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSA LLIEQYHEQMKNAQRGKVKGKSSEATSALAGLL EEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYE GCVDTALKTALHLKDYEDIIPPVEIYSLLALCA CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDL ALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVA TGSPITEYQFWMCSVCKHGVLAQEISHYSFCPL CHSPVG*RNDKLYITVKYM*HIYMAICCICNKV YFCEFCMKISLIIYS*IFAQNIC**NNFYGNTTV K**GRFSYKCMKINHVFSHPLSFVYLVFGYMIP WKYSK*IFFSQCQGN*IH*KILKGVGSGGSMGV GQS*I*RIFITHVTRKLNNCNNEMSFLYSHI*LN KCRMSSLLYFQK*GDGILRHFLQSELFLIALFF YFKTCPFSLI*EMAFGIYTFI*LCRKLASIYNE DNLNRNIHFVVIASVETLSLSWTVYLHKYC*GSD FFLICVCFHLLLI*KINSCDP*WIISYVFYIAN NVLCLFLMNSHFVAKDQTFALFHQDYFIEVWLT YSRGNT*RYATLFLQLQYTFSISYVFVL*RQRQV QHVADWE**AMRRDLEPR*A*DREWAHWPK*KE KTRSL*GLCLYSCASWKITLVQW*PLNRLPRKL FQRSWNRKPYKPNKNSQNTLVY*TNLQYTVRNKE KAMID*HC*CNVPVEWKDRNT*ILGFVMFLCPD SHSVTYAFP**SGYKKDQSGRLSQMTQSDEMCL RPTMYTCSIEGCQGQVHFTTAIACLLVC*AVMNF IVFLG*GQARMSVTSG*LNQLLTHTEGFICLMH T*CIMNIWYLCGFSYF*CFMNIWYLLLLSICGH TYTLY*LCLISLLGY*LTYLNVTQ*IPAFSFVLY QNGKFPQIRKSHPNKEVCLRQYISC*TCIFPQD FLFLGMRLFSASSRKEKCSGL*GWHTY*FCLSE RFLQDSLVRAAILSPWSNA*VSLLSLSCLRNQLR IHSIVMPLAPYCDLLVALSFALVLESPVDSSDF T*LWKLSFGGFSFPPNSVLPEP*NFPTNELFQV DPKLLDLVDI*TISS*YFSFSWIQKPVSLKTTSH TLWT*FCVRVCVRAYVYRQAHLFYFCKSLCLFG IYICESFNDLP*CLGDLCLLCKWY*RKHLYYES I*LVLFDMKEISR*QH*QTLP*LGGQRKAKLTIK NNYLVRSCINRIR*YIEDSIIKQLCCSPCKKHV LTSR*VMPSCFFYYKTCPSLHVSKWCGGPKY*N DGTD**SCTNKQCA*QATQ*C*HA*FTNANFIIN CFAKIHFETIFLYSKS*DLRFYVVLSEKIRK** TLKKK

Frame 1

RATGAFRSCWYSRLET*NRYLSRALAAAVTLSG IPRCSST*ARKFPFPIT*SCSVYPGTRNKGS*H AVVKMDY*KF*N*RRRQMMQN*GALQPPVTFL*I RLLKVIVVLFKL*HGMSSIRS*LPVMKTGLSLC GCYIKALGLRR*STIEINQLFAV*AGMLTDRRS ALYMKMGL**LVQWMAIVFGEKT*RVYSYPM*HG LRTVKSYFLEWQMGKYTFTIIKEIL**K*N*VV W*MSLELSALLEFIGTMAQKATWSLIALALLFA LIMEDAK**DMRMTKIPF*LTLACT**ASSGTTW AAC*LWQASRRQPCRTKM*TLCSFTLRLVSIWV L*KFLERKYLHYLGKEVD*KLH*LLIPLYILQT FDLIISGVIAQTL*FMHIPDLIVQNIVLSSGIRK TMKNMLNM*RVSFLLLPVEISAFWLQKLMKIIL SLY*FFVILLVHPWIPNTLILYHCLLQ*PKPM* *QPRKKHFIPGNIVWQRSSQHWKLIRSHGLEKKG EKEFIMLMIPLLDQWMVCLIIVKPFKAQGIQFV P*LHQIRY*LWVVNLAPFRDTVYLMLV*FKNIP LIVEPTSYP*IATLAVLLS*TSQEF*LSLTWMLE *RTVRDSK*LESC*NWNEEMSGI*SGPKIILIC LQ*WRRQECMFSETWILRNPFRPLDIFVILRI* KLNLFFWMRY*RIQNIQTRIT*LTLRFGLCEIAE H*LRRLELKMHLSS*RTIHTPDFGAYWLKQLFR NWIYTLQSKHLCAAKITKALSL*SAWANY*VSQ *NRLKLLATSAGLKRLKERISRWTEGILLLASG* NWGIGLEYSSS*KLDLVMQMTVSWNKPTMPLET TLLIDKSG*MLYNIMYKDGTRNA*LNVTIC*RI MKG*RTLPFHFQKTTSYFQK*HKCLSELECVNKQ *LHF*NVVNQRQQ*IPAYISTNGTKLLNWLKII V*KKLDLC*LGMHLIYWKRIKLLMP*NSIGKPI TFLMQLN*CLRLQMKRQRKEVNLYVSRSSMYCQP YL*SNTMNR*RMPSEEKLKEKVQRPLLPWLVCW KKKFCLQQIVSQIMHGEGQRLTTSLYLHRGSSM RDVWTLH*RQLFT*KTMKTSSLLWRSTLC*HSAH APAEPLGLVQKLSLNLNL*RPSVQNRNSSMKTL L*KSSPNILQKITENLNWTALWKVEKGNCQHAL PQEAQSLSINSGCAVYANTVSLLRK*ATTASAPY AIVQWDKGMINCI*L*NICSIYTWLYAVYVIRF ISVSFV*KSASLFIVEFLHKIYVNKIIFMAIQL *NNKADFHINV*KSTMFSLTLSLLFILFLVT*YH GNIPNKFFSHSVKVTEFIKKS*RE*GVGEAWEW GKVEFREFL*PMLQGS*TIVIMK*AFSIAIFN* ISVECLLYCIFRSEAMAF*DIFYNLNCF**PYSS ILKPVLLVSFKRWHLEFTLSYDCAENLPLFIMK IT*TEISIL*L*LLLKHCH*VGPFIYTSIVEGV IFS*YASVFIYY*FER*TVVIHNGSFLMSFT*LI MFSVYFS*IPILWLKTRPLHYFIKIILLRFGLH IVEAIHRDTQLCFCSYNTLSQSHMFLSCRDRDK FSMLQIGNSEL*EEI*SLDELRIESGLIGLNKKR RPEVFEVSVSIHAPRGKLPWYNGSL*IDCLASY SRGHGTESLINQIKILKIHWFIEPICNTQ*GTR RKQ**INTVSVTCQWSGKTATPESWVL*CFYVLT HILSHTLSPNSRVTKRTRVAA*AR*LNQMKCA* GQRCTLAL*KGVRGKYTSPQQ*LAY*SAEQS*I LLYFLGKDRPE*VSPVGN*INFSHILKALYVSCI LSVS*IFGIFVAFHIFSAS*IFGISCSFLSVVT HTRSINFA**VS*VTNLLT*M*HNEFQLSHLFY TRMGNFPKSENHILTKKSV*DSTSPVELASFHRT FCF*G*DYSLLHQGKRNVQGCRDGTLISSACLK GSCRTVWSELQFLVHGLMLEYLFFPFPVSGIS* EFIRLSCL*PLTVICWLHFHLL*F*NHLLTPQTS PNFGNSLLEASHFPLILCCLSPRIFPPTNYSR* ILSCWI*LIFKQYLVDISHSVGSRNQYL*KQPL IPCGPNFVCVCVCAHMYIDRHIFFTFVKAYASLV SISVKVLMICHNVLGTFVFCVNGTRENTYIMSQ SSWFYST*RKFPDNNTNKLSLD*GDKEKQN*P* KTITW*EVA*TELGSILKTASLNSYVVLLAKNMY *LPVE*CQVVFFIIKLALHYMFQSGVVGQNIEM MELTDKAVQISSVPNKQHSNVDMLNSQMLISL* IVLLKYTLKLFFCIPRAEILDFM*Y*VKKYENNK H*RKK

Frame 2

GRRELSGAAGTPDWRRRTVTCRGP*RPP*PSRG SHDVLLPEQENFHSQ*REAAVCILEQGTRVHSM RW*RWITESFEIRDADR*CKIEGPCSPQ*PFYE SDS*RS*WFCSSCNME*AVSEVDYQ**KRAYHCV DVI*RLLD*GDDQQSK*ISCSQYELEC*RTEDL HCI*RWGCDSWFSGWQSYLGKRPEGYTAIPCNM VCGQ*SLTFWNGKWGNTHLR*SRKFYDKNETELF GECHWSYQHCWNSLVPWHRRLRGA*LPLPCCLL **WKMPNNET*E*PKSRFD*HWHVRSRHPVEPH GQRVSCGRLPEGSHAGQRCEHCAVLHSVW*ASGY FESSWKGNICTILGRRWTENCTSC*FLYIFCKH ST*L*VGLLLKHCSLCIYQT*SSRILCCLLGYE KQ*KIC*ICEGSHFYYYLWRFLHFGYKS**KSSS VCTSSL*FYWYTLGSQIH*YCTIVCCNDQNPCD SSLERSILYLAISCGKEAHSIGN*SDHTVSKRR ERKNLSC**YPFWINGWCA*L**NHSRHKGSNLC HNCIR*DIDCGS*IWHHSEIQST*CWFDSKIFP *LSSLPVILELQL*PSCYHRHLRSSDFL*LGCS SNGQYGTASSWRVVKIGTKRCLGYEVGQR*S*FV CNDGEDKNVCFQKLGS*GTHSDLWIYL*F*GFR N*ICSFG*DIKGSRTSKQGLPN*L*DSVSAR*P STD*EGWN*RCISVHRGQSTPPTLAPTG*SSSSE TGSIHCRASICALQRLPRH*VCEALGQTTE*VN ETG*SCWLLRQV*RG*KNVSRDGQKGSCYWPPA EIGGLV*STPAPENWIW*CR*QSPGTSQQCHWRL LC*STKVVECCTILCTRTEPGTLS*MLLYVRGL *RVREPCHFTSRKPQVTSRNSTNVCQSWNV*TS SDCIFEM*STKGSSRYLRTSQPMEQSC*IG*KS* YERNWISVS*VCISFTGKE*NS*CHRTLSESQL LF*CS*TDV*DCR*RGKERK*TFTCQEALCTVS LTYRAIP*TDEECPARKS*RKKFRGHFCLGWFAG RRSSVYNRSFHR*CMERGRGLPLLYTCTEAAL* GMCGHCTEDSSSPERL*RHHPSCGDLLSASTLR MRQQSLWDLFKSFH*T*IFRDPQFRTETAV*RPC FRNLHQTYFKR*QKT*IGQPYGRWRRETANMRC HRKPNH*VSILDVQCMQTRCPCSGNKPLQLLPL MP*SSGIKE**TVYNCKIYVAYIHGYMLYM**GL FL*VLYENQPHYL*LNFCTKYMLIK*FLWQYNC EIIRPIFI*MYENQPCFLSPSLFCLSCFWLHDT MEIFQINFFLTVSR*LNSLKNLEGSREWGKHGSG AKLNLENFYNPCYKEVKQL***NELSL*PYLIK *VSNVFFIVFSEVRRWHFKTFFTI*IVSNSPIL LF*NLSF*SHLRDGIWNLHFHMIVQKTCLYL**R *LKQKYPFCSYSFC*NIVTKLDRLFTQVLLRE* FFLDMRLFSFIINLKDKQL*SIMDHFLCLLHS* *CSLFISHEFPFCG*RPDLCTISSRLFY*GLAYI **RQYIEIRNFVFAATIHFLNLICFCLVETETS SACCRLGIVSYEKRFRA*MSLG*RVGSLA*IKR EDQKSLRSLSLFMRLVENYLGTMVASK*TASQAI PEVMEQKAL*TK*KFSKYIGLLNQFAIHSEEQG ESNDRLTLLV*RASGVERPQHLNPGFCNVFMS* LTFCHIRFPLIVGLQKGPEWPLEPDDSIR*NVPE ANDVHLLYRRVSGASTLHHSNSLPISLLSSHEF YCISWVRTGQNECHQWVIESTSHTY*RLYMSHA YLVYHEYLVSLWLFIFLVLHEYLVSLAPFYLWSH IHALLTLPNKSPRLLTYLPKCNTMNSSFLICSI PEWEISPNQKITS*QRSLSKTVHLLLNLHLSTG LSVFRDETILCFIKEREMFRVVGMAHLLVLPV*K VPAGQFGQSCNS*SMV*CLSISSFPFLSQESAE NSFDCHASSPLL*FVGCTFICFSSRITC*LLRL HLTLETLFWRLLISP*FCAA*ALEFSHQRIIPGR S*VAGSS*YLNNI*LIFLIQLDPETSISKNNLS YLVDLILCACVCARICI*TGTSFLLL*KLMPLW YLYL*KF**SAIMSWGPLSSV*MVLEKTPIL*VN LVGFIRHEGNFQITTLTNSPLTRGTKKSKTDHK KQLPGEKLHKQN*VVY*RQHH*TVMLFSLQKTC TDFPLSNAKLFFLL*NLPFITCFKVVWWAKILK* WN*LIKLYK*AVCLTSNTVMLTCLIHKC*FHYK LFC*NTL*NYFSVFQELRS*ILCSIK*KNTKII NIEEK

Sequence NM_001006657

CAGGGCGACGGGAGCTTTCCGGAGCTGCTGGTACTCCCGATTGGAGACGTAGAACCGTTACTTGTCGAGGGCCTTAGCGGCCGCCGTGACCCTCTCGGGG ATCCCACGATGTTCTTCTACCTGAGCAAGAAAATTTCCATTCCCAATAACGTGAAGCTGCAGTGTGTATCCTGGAACAAGGAACAAGGGTTCATAGCATG CGGTGGTGAAGATGGATTACTGAAAGTTTTGAAATTAGAGACGCAGACAGATGATGCAAAATTGAGGGGCCTTGCAGCCCCCAGTAACCTTTCTATGAAT CAGACTCTTGAAGGTCATAGTGGTTCTGTTCAAGTTGTAACATGGAATGAGCAGTATCAGAAGTTGACTACCAGTGATGAAAACGGGCTTATCATTGTGT GGATGTTATATAAAGGCTCTTGGATTGAGGAGATGATCAACAATCGAAATAAATCAGTTGTTCGCAGTATGAGCTGGAATGCTGACGGACAGAAGATCTG CATTGTATATGAAGATGGGGCTGTGATAGTTGGTTCAGTGGATGGCAATCGTATTTGGGGAAAAGACCTGAAGGGTATACAGCTATCCCATGTAACATGG TCTGCGGACAGTAAAGTCTTACTTTTTGGAATGGCAAATGGGGAAATACACATTTACGATAATCAAGGAAATTTTATGATAAAAATGAAACTGAGTTGTT TGGTGAATGTCACTGGAGCTATCAGCATTGCTGGAATTCATTGGTACCATGGCACAGAAGGCTACGTGGAGCCTGATTGCCCTTGCCTTGCTGTTTGCTT TGATAATGGAAGATGCCAAATAATGAGACATGAGAATGACCAAAATCCCGTTTTGATTGACACTGGCATGTACGTAGTAGGCATCCAGTGGAACCACATG GGCAGCGTGTTAGCTGTGGCAGGCTTCCAGAAGGCAGCCATGCAGGACAAAGATGTGAACATTGTGCAGTTTTACACTCCGTTTGGTGAGCATCTGGGTA CTTTGAAAGTTCCTGGAAAGGAAATATCTGCACTATCTTGGGAAGGAGGTGGACTGAAAATTGCACTAGCTGTTGATTCCTTTATATATTTTGCAAACAT TCGACCTAATTATAAGTGGGGTTATTGCTCAAACACTGTAGTTTATGCATATACCAGACCTGATCGTCCAGAATATTGTGTTGTCTTCTGGGATACGAAA AACAATGAAAAATATGTTAAATATGTGAAGGGTCTCATTTCTATTACTACCTGTGGAGATTTCTGCATTTTGGCTACAAAAGCTGATGAAAATCATCCTC AGGAGGAGAACGAGATGGAGACATTTGGTGCAACGTTTGTACTAGTTCTTTGTAATTCTATTGGTACACCCTTGGATCCCAAATACATTGATATTGTACC ATTGTTTGTTGCAATGACCAAAACCCATGTGATAGCAGCCTCGAAAGAAGCATTTTATACCTGGCAATATCGTGTGGCAAAGAAGCTCACAGCATTGGAA ATTAATCAGATCACACGGTCTCGAAAAGAAGGGAGAGAAAGAATTTATCATGTTGATGATACCCCTTCTGGATCAATGGATGGTGTGCTTGATTATAGTA AAACCATTCAAGGCACAAGGGATCCAATTTGTGCCATAACTGCATCAGATAAGATATTGATTGTGGGTCGTGAATCTGGCACCATTCAGAGATACAGTCT ACCTAATGTTGGTTTGATTCAAAAATATTCCCTTAATTGTCGAGCCTACCAGTTATCCTTGAATTGCAACTCTAGCCGTCTTGCTATCATAGACATCTCA GGAGTTCTGACTTTCTTTGACTTGGATGCTCGAGTAACGGACAGTACGGGACAGCAAGTAGTTGGAGAGTTGTTAAAATTGGAACGAAGAGATGTCTGGG ATATGAAGTGGGCCAAAGATAATCCTGATTTGTTTGCAATGATGGAGAAGACAAGAATGTATGTTTTCAGAAACTTGGATCCTGAGGAACCCATTCAGAC CTCTGGATATATTTGTAATTTTGAGGATTTAGAAATTAAATCTGTTCTTTTGGATGAGATATTAAAGGATCCAGAACATCCAAACAAGGATTACCTAATT AACTTTGAGATTCGGTCTCTGCGAGATAGCCGAGCACTGATTGAGAAGGTTGGAATTAAAGATGCATCTCAGTTCATAGAGGACAATCCACACCCCCGAC TTTGGCGCCTACTGGCTGAAGCAGCTCTTCAGAAACTGGATCTATACACTGCAGAGCAAGCATTTGTGCGCTGCAAAGATTACCAAGGCATTAAGTTTGT GAAGCGCTTGGGCAAACTACTGAGTGAGTCAATGAAACAGGCTGAAGTTGTTGGCTACTTCGGCAGGTTTGAAGAGGCTGAAAGAACGTATCTCGAGATG GACAGAAGGGATCTTGCTATTGGCCTCCGGCTGAAATTGGGGGATTGGTTTAGAGTACTCCAGCTCCTGAAAACTGGATCTGGTGATGCAGATGACAGTC TCCTGGAACAAGCCAACAATGCCATTGGAGACTACTTTGCTGATCGACAAAAGTGGTTGAATGCTGTACAATATTATGTACAAGGACGGAACCAGGAACG CTTAGCTGAATGTTACTATATGTTAGAGGATTATGAAGGGTTAGAGAACCTTGCCATTTCACTTCCAGAAAACCACAAGTTACTTCCAGAAATAGCACAA ATGTTTGTCAGAGTTGGAATGTGTGAACAAGCAGTGACTGCATTTTTGAAATGTAGTCAACCAAAGGCAGCAGTAGATACCTGCGTACATCTCAACCAAT GGAACAAAGCTGTTGAATTGGCTAAAAATCATAGTATGAAAGAAATTGGATCTCTGTTAGCTAGGTATGCATCTCATTTACTGGAAAAGAATAAAACTCT TGATGCCATAGAACTCTATCGGAAAGCCAATTACTTTTTTGATGCAGCTAAACTGATGTTTAAGATTGCAGATGAAGAGGCAAAGAAAGGAAGTAAACCT TTACGTGTCAAGAAGCTCTATGTACTGTCAGCCTTACTTATAGAGCAATACCATGAACAGATGAAGAATGCCCAGCGAGGAAAAGTTAAAGGAAAAAGTT CAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCA CTTCTTTATACTTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCT GTGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCA GTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGA AGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTCCTTGCT CAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATGATAAACTGTATATAACTGTAAAATATATGTAGCATATAT ACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTATGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATG TTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAATAAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCT TTTGTTTATCTTGTTTTTGGTTACATGATACCATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGA AGGGAGTAGGGAGTGGGGGAAGCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGA AATGAGCTTTCTCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTA CAATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTTTCATATGAT TGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAACATTGTCACTAAGTTGGAC CGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAATTTGAAAGATAAACAGTTGTGATCCATAA TGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATTCCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTC ATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACATAGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTC ATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATGTTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGAT AGAGAGTGGGCTCATTGGCCTAAATAAAAAGAGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAAT GGTAGCCTCTAAATAGACTGCCTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTG AACCAATTTGCAATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGA ATCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTGGCCGCTTGA GCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTACACTTCACCACAGCAATAGC TTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTGTCACCAGTGGGTAATTGAATCAACTTCTC ACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATCTTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTT GGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAACTTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAAC ACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATGGGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTAC ATCTCCTGTTGAACTTGCATCTTTCCACAGGACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGG GATGGCACACTTATTAGTTCTGCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCT TCTTTCCCTTTCCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTA GTTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGCCTGAGCCCT AGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGATATTTCTCATTCAGTTGGAT CCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGCGCGCATATGTATATAGACAGGCACATCTT TTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATCTGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAAT GGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCGACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACT AGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATTACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAA CAGTTATGTTGTTCTCCTTGCAAAAAACATGTACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTT CAAAGTGGTGTGGTGGGCCAAAATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACA TGCTTAATTCACAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTAT GTAGTATTAAGTGAAAAAATACGAAAATAATAAACATTGAAGAAAAAAA

refseq_WDR35.F1 (forward primer)
refseq_WDR35.R1 (reverse primer)
Single exon skipping

Frame 0

QGDGSFPELLVLPIGDVEPLLVEGLSGRRDPLG DPTMFFYLSKKISIPNNVKLQCVSWNKEQGFIAC GGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMN QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIV WMLYKGSWIEEMINNRNKSVVRSMSWNADGQKIC IVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTW SADSKVLLFGMANGEIHIYDNQGNFMIKMKLSC LVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCF DNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHM GSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLG TLKVPGKEISALSWEGGGLKIALAVDSFIYFANI RPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTK NNEKYVKYVKGLISITTCGDFCILATKADENHP QEENEMETFGATFVLVLCNSIGTPLDPKYIDIVP LFVAMTKTHVIAASKEAFYTWQYRVAKKLTALE INQITRSRKEGRERIYHVDDTPSGSMDGVLDYS KTIQGTRDPICAITASDKILIVGRESGTIQRYSL PNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDIS GVLTFFDLDARVTDSTGQQVVGELLKLERRDVW DMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQT SGYICNFEDLEIKSVLLDEILKDPEHPNKDYLI NFEIRSLRDSRALIEKVGIKDASQFIEDNPHPR LWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEM DRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDS LLEQANNAIGDYFADRQKWLNAVQYYVQGRNQER LAECYYMLEDYEGLENLAISLPENHKLLPEIAQ MFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQ WNKAVELAKNHSMKEIGSLLARYASHLLEKNKTL DAIELYRKANYFFDAAKLMFKIADEEAKKGSKP LRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKS SEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYH FFILAQRQLYEGCVDTALKTALHLKDYEDIIPP VEIYSLLALCACASRAFGTCSKAFIKLKSLETL SSEQKQQYEDLALEIFTKHTSKDNRKPELDSLME GGEGKLPTCVATGSPITEYQFWMCSVCKHGVLA QEISHYSFCPLCHSPVG*RNDKLYITVKYM*HI YMAICCICNKVYFCEFCMKISLIIYS*IFAQNIC **NNFYGNTTVK**GRFSYKCMKINHVFSHPLS FVYLVFGYMIPWKYSK*IFFSQCQGN*IH*KIL KGVGSGGSMGVGQS*I*RIFITHVTRKLNNCNNE MSFLYSHI*LNKCRMSSLLYFQK*GDGILRHFL QSELFLIALFFYFKTCPFSLI*EMAFGIYTFI* LCRKLASIYNEDNLNRNIHFVVIASVETLSLSWT VYLHKYC*GSDFFLICVCFHLLLI*KINSCDP* WIISYVFYIANNVLCLFLMNSHFVAKDQTFALF HQDYFIEVWLTYSRGNT*RYATLFLQLQYTFSIS YVFVL*RQRQVQHVADWE**AMRRDLEPR*A*D REWAHWPK*KEKTRSL*GLCLYSCASWKITLVQ W*PLNRLPRKLFQRSWNRKPYKPNKNSQNTLVY* TNLQYTVRNKEKAMID*HC*CNVPVEWKDRNT* ILGFVMFLCPDSHSVTYAFP**SGYKKDQSGRL SQMTQSDEMCLRPTMYTCSIEGCQGQVHFTTAIA CLLVC*AVMNFIVFLG*GQARMSVTSG*LNQLL THTEGFICLMHT*CIMNIWYLCGFSYF*CFMNI WYLLLLSICGHTYTLY*LCLISLLGY*LTYLNVT Q*IPAFSFVLYQNGKFPQIRKSHPNKEVCLRQY ISC*TCIFPQDFLFLGMRLFSASSRKEKCSGL* GWHTY*FCLSERFLQDSLVRAAILSPWSNA*VSL LSLSCLRNQLRIHSIVMPLAPYCDLLVALSFAL VLESPVDSSDFT*LWKLSFGGFSFPPNSVLPEP *NFPTNELFQVDPKLLDLVDI*TISS*YFSFSWI QKPVSLKTTSHTLWT*FCVRVCVRAYVYRQAHL FYFCKSLCLFGIYICESFNDLP*CLGDLCLLCK WY*RKHLYYESI*LVLFDMKEISR*QH*QTLP*L GGQRKAKLTIKNNYLVRSCINRIR*YIEDSIIK QLCCSPCKKHVLTSR*VMPSCFFYYKTCPSLHV SKWCGGPKY*NDGTD**SCTNKQCA*QATQ*C*H A*FTNANFIINCFAKIHFETIFLYSKS*DLRFY VVLSEKIRK**TLKKK

Frame 1

RATGAFRSCWYSRLET*NRYLSRALAAAVTLSG IPRCSST*ARKFPFPIT*SCSVYPGTRNKGS*H AVVKMDY*KF*N*RRRQMMQN*GALQPPVTFL*I RLLKVIVVLFKL*HGMSSIRS*LPVMKTGLSLC GCYIKALGLRR*STIEINQLFAV*AGMLTDRRS ALYMKMGL**LVQWMAIVFGEKT*RVYSYPM*HG LRTVKSYFLEWQMGKYTFTIIKEIL**K*N*VV W*MSLELSALLEFIGTMAQKATWSLIALALLFA LIMEDAK**DMRMTKIPF*LTLACT**ASSGTTW AAC*LWQASRRQPCRTKM*TLCSFTLRLVSIWV L*KFLERKYLHYLGKEVD*KLH*LLIPLYILQT FDLIISGVIAQTL*FMHIPDLIVQNIVLSSGIRK TMKNMLNM*RVSFLLLPVEISAFWLQKLMKIIL RRRTRWRHLVQRLY*FFVILLVHPWIPNTLILY HCLLQ*PKPM**QPRKKHFIPGNIVWQRSSQHWK LIRSHGLEKKGEKEFIMLMIPLLDQWMVCLIIV KPFKAQGIQFVP*LHQIRY*LWVVNLAPFRDTV YLMLV*FKNIPLIVEPTSYP*IATLAVLLS*TSQ EF*LSLTWMLE*RTVRDSK*LESC*NWNEEMSG I*SGPKIILICLQ*WRRQECMFSETWILRNPFR PLDIFVILRI*KLNLFFWMRY*RIQNIQTRIT*L TLRFGLCEIAEH*LRRLELKMHLSS*RTIHTPD FGAYWLKQLFRNWIYTLQSKHLCAAKITKALSL *SAWANY*VSQ*NRLKLLATSAGLKRLKERISRW TEGILLLASG*NWGIGLEYSSS*KLDLVMQMTV SWNKPTMPLETTLLIDKSG*MLYNIMYKDGTRN A*LNVTIC*RIMKG*RTLPFHFQKTTSYFQK*HK CLSELECVNKQ*LHF*NVVNQRQQ*IPAYISTN GTKLLNWLKIIV*KKLDLC*LGMHLIYWKRIKL LMP*NSIGKPITFLMQLN*CLRLQMKRQRKEVNL YVSRSSMYCQPYL*SNTMNR*RMPSEEKLKEKV QRPLLPWLVCWKKKFCLQQIVSQIMHGEGQRLT TSLYLHRGSSMRDVWTLH*RQLFT*KTMKTSSLL WRSTLC*HSAHAPAEPLGLVQKLSLNLNL*RPS VQNRNSSMKTLL*KSSPNILQKITENLNWTALW KVEKGNCQHALPQEAQSLSINSGCAVYANTVSLL RK*ATTASAPYAIVQWDKGMINCI*L*NICSIY TWLYAVYVIRFISVSFV*KSASLFIVEFLHKIY VNKIIFMAIQL*NNKADFHINV*KSTMFSLTLSL LFILFLVT*YHGNIPNKFFSHSVKVTEFIKKS* RE*GVGEAWEWGKVEFREFL*PMLQGS*TIVIM K*AFSIAIFN*ISVECLLYCIFRSEAMAF*DIFY NLNCF**PYSSILKPVLLVSFKRWHLEFTLSYD CAENLPLFIMKIT*TEISIL*L*LLLKHCH*VG PFIYTSIVEGVIFS*YASVFIYY*FER*TVVIHN GSFLMSFT*LIMFSVYFS*IPILWLKTRPLHYF IKIILLRFGLHIVEAIHRDTQLCFCSYNTLSQS HMFLSCRDRDKFSMLQIGNSEL*EEI*SLDELRI ESGLIGLNKKRRPEVFEVSVSIHAPRGKLPWYN GSL*IDCLASYSRGHGTESLINQIKILKIHWFI EPICNTQ*GTRRKQ**INTVSVTCQWSGKTATPE SWVL*CFYVLTHILSHTLSPNSRVTKRTRVAA* AR*LNQMKCA*GQRCTLAL*KGVRGKYTSPQQ* LAY*SAEQS*ILLYFLGKDRPE*VSPVGN*INFS HILKALYVSCILSVS*IFGIFVAFHIFSAS*IF GISCSFLSVVTHTRSINFA**VS*VTNLLT*M* HNEFQLSHLFYTRMGNFPKSENHILTKKSV*DST SPVELASFHRTFCF*G*DYSLLHQGKRNVQGCR DGTLISSACLKGSCRTVWSELQFLVHGLMLEYL FFPFPVSGIS*EFIRLSCL*PLTVICWLHFHLL* F*NHLLTPQTSPNFGNSLLEASHFPLILCCLSP RIFPPTNYSR*ILSCWI*LIFKQYLVDISHSVG SRNQYL*KQPLIPCGPNFVCVCVCAHMYIDRHIF FTFVKAYASLVSISVKVLMICHNVLGTFVFCVN GTRENTYIMSQSSWFYST*RKFPDNNTNKLSLD *GDKEKQN*P*KTITW*EVA*TELGSILKTASLN SYVVLLAKNMY*LPVE*CQVVFFIIKLALHYMF QSGVVGQNIEMMELTDKAVQISSVPNKQHSNVD MLNSQMLISL*IVLLKYTLKLFFCIPRAEILDFM *Y*VKKYENNKH*RKK

Frame 2

GRRELSGAAGTPDWRRRTVTCRGP*RPP*PSRG SHDVLLPEQENFHSQ*REAAVCILEQGTRVHSM RW*RWITESFEIRDADR*CKIEGPCSPQ*PFYE SDS*RS*WFCSSCNME*AVSEVDYQ**KRAYHCV DVI*RLLD*GDDQQSK*ISCSQYELEC*RTEDL HCI*RWGCDSWFSGWQSYLGKRPEGYTAIPCNM VCGQ*SLTFWNGKWGNTHLR*SRKFYDKNETELF GECHWSYQHCWNSLVPWHRRLRGA*LPLPCCLL **WKMPNNET*E*PKSRFD*HWHVRSRHPVEPH GQRVSCGRLPEGSHAGQRCEHCAVLHSVW*ASGY FESSWKGNICTILGRRWTENCTSC*FLYIFCKH ST*L*VGLLLKHCSLCIYQT*SSRILCCLLGYE KQ*KIC*ICEGSHFYYYLWRFLHFGYKS**KSSS GGERDGDIWCNVCTSSL*FYWYTLGSQIH*YCT IVCCNDQNPCDSSLERSILYLAISCGKEAHSIG N*SDHTVSKRRERKNLSC**YPFWINGWCA*L** NHSRHKGSNLCHNCIR*DIDCGS*IWHHSEIQS T*CWFDSKIFP*LSSLPVILELQL*PSCYHRHL RSSDFL*LGCSSNGQYGTASSWRVVKIGTKRCLG YEVGQR*S*FVCNDGEDKNVCFQKLGS*GTHSD LWIYL*F*GFRN*ICSFG*DIKGSRTSKQGLPN *L*DSVSAR*PSTD*EGWN*RCISVHRGQSTPPT LAPTG*SSSSETGSIHCRASICALQRLPRH*VC EALGQTTE*VNETG*SCWLLRQV*RG*KNVSRD GQKGSCYWPPAEIGGLV*STPAPENWIW*CR*QS PGTSQQCHWRLLC*STKVVECCTILCTRTEPGT LS*MLLYVRGL*RVREPCHFTSRKPQVTSRNST NVCQSWNV*TSSDCIFEM*STKGSSRYLRTSQPM EQSC*IG*KS*YERNWISVS*VCISFTGKE*NS *CHRTLSESQLLF*CS*TDV*DCR*RGKERK*T FTCQEALCTVSLTYRAIP*TDEECPARKS*RKKF RGHFCLGWFAGRRSSVYNRSFHR*CMERGRGLP LLYTCTEAAL*GMCGHCTEDSSSPERL*RHHPS CGDLLSASTLRMRQQSLWDLFKSFH*T*IFRDPQ FRTETAV*RPCFRNLHQTYFKR*QKT*IGQPYG RWRRETANMRCHRKPNH*VSILDVQCMQTRCPC SGNKPLQLLPLMP*SSGIKE**TVYNCKIYVAYI HGYMLYM**GLFL*VLYENQPHYL*LNFCTKYM LIK*FLWQYNCEIIRPIFI*MYENQPCFLSPSL FCLSCFWLHDTMEIFQINFFLTVSR*LNSLKNLE GSREWGKHGSGAKLNLENFYNPCYKEVKQL*** NELSL*PYLIK*VSNVFFIVFSEVRRWHFKTFF TI*IVSNSPILLF*NLSF*SHLRDGIWNLHFHMI VQKTCLYL**R*LKQKYPFCSYSFC*NIVTKLD RLFTQVLLRE*FFLDMRLFSFIINLKDKQL*SI MDHFLCLLHS**CSLFISHEFPFCG*RPDLCTIS SRLFY*GLAYI**RQYIEIRNFVFAATIHFLNL ICFCLVETETSSACCRLGIVSYEKRFRA*MSLG *RVGSLA*IKREDQKSLRSLSLFMRLVENYLGTM VASK*TASQAIPEVMEQKAL*TK*KFSKYIGLL NQFAIHSEEQGESNDRLTLLV*RASGVERPQHL NPGFCNVFMS*LTFCHIRFPLIVGLQKGPEWPLE PDDSIR*NVPEANDVHLLYRRVSGASTLHHSNS LPISLLSSHEFYCISWVRTGQNECHQWVIESTS HTY*RLYMSHAYLVYHEYLVSLWLFIFLVLHEYL VSLAPFYLWSHIHALLTLPNKSPRLLTYLPKCN TMNSSFLICSIPEWEISPNQKITS*QRSLSKTV HLLLNLHLSTGLSVFRDETILCFIKEREMFRVVG MAHLLVLPV*KVPAGQFGQSCNS*SMV*CLSIS SFPFLSQESAENSFDCHASSPLL*FVGCTFICF SSRITC*LLRLHLTLETLFWRLLISP*FCAA*AL EFSHQRIIPGRS*VAGSS*YLNNI*LIFLIQLD PETSISKNNLSYLVDLILCACVCARICI*TGTS FLLL*KLMPLWYLYL*KF**SAIMSWGPLSSV*M VLEKTPIL*VNLVGFIRHEGNFQITTLTNSPLT RGTKKSKTDHKKQLPGEKLHKQN*VVY*RQHH* TVMLFSLQKTCTDFPLSNAKLFFLL*NLPFITCF KVVWWAKILK*WN*LIKLYK*AVCLTSNTVMLT CLIHKC*FHYKLFC*NTL*NYFSVFQELRS*IL CSIK*KNTKIINIEEK