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Sequences

Sequence NM_021055

GGTGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATC CCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGAT AGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCG CTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCA AGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGC TGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTAC ATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCG GAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGA GCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGGCCATGG CATGTCCGAACGAGGTGGTGTCCTATGAGATCGTCCTGTCCATCACCAGGCTCATCAAGAAGTATAGGAAGGAGCTCCAGGTGGTGGCGTGGGACATTCT GCTGAACATCATCGAACGGCTCCTTCAGCAGCTCCAGACCTTGGACAGCCCGGAGCTCAGGACCATCGTCCATGACCTGTTGACCACGGTGGAGGAGCTG TGTGACCAGAACGAGTTCCACGGGTCTCAGGAGAGATACTTTGAACTGGTGGAGAGATGTGCGGACCAGAGGCCTGAGTCCTCCCTCCTGAACCTGATCT CCTATAGAGCGCAGTCCATCCACCCGGCCAAGGACGGCTGGATTCAGAACCTGCAGGCGCTGATGGAGAGATTCTTCAGGAGCGAGTCCCGAGGCGCCGT GCGCATCAAGGTGCTGGACGTGCTGTCCTTTGTGCTGCTCATCAACAGGCAGTTCTATGAGGAGGAGCTGATTAACTCAGTGGTCATCTCGCAGCTCTCC CACATCCCCGAGGATAAAGACCACCAGGTCCGAAAGCTGGCCACCCAGTTGCTGGTGGACCTGGCAGAGGGCTGCCACACACACCACTTCAACAGCCTGC TGGACATCATCGAGAAGGTGATGGCCCGCTCCCTCTCCCCACCCCCGGAGCTGGAAGAAAGGGATGTGGCCGCATACTCGGCCTCCTTGGAGGATGTGAA GACAGCCGTCCTGGGGCTTCTGGTCATCCTTCAGACCAAGCTGTACACCCTGCCTGCAAGCCACGCCACGCGTGTGTATGAGATGCTGGTCAGCCACATT CAGCTCCACTACAAGCACAGCTACACCCTGCCAATCGCGAGCAGCATCCGGCTGCAGGCCTTTGACTTCCTGTTGCTGCTGCGGGCCGACTCACTGCACC GCCTGGGCCTGCCCAACAAGGATGGAGTCGTGCGGTTCAGCCCCTACTGCGTCTGCGACTACATGGAGCCAGAGAGAGGCTCTGAGAAGAAGACCAGCGG CCCCCTTTCTCCTCCCACAGGGCCTCCTGGCCCGGCGCCTGCAGGCCCCGCCGTGCGGCTGGGGTCCGTGCCCTACTCCCTGCTCTTCCGCGTCCTGCTG CAGTGCTTGAAGCAGGAGTCTGACTGGAAGGTGCTGAAGCTGGTTCTGGGCAGGCTGCCTGAGTCCCTGCGCTATAAAGTGCTCATCTTTACTTCCCCTT GCAGTGTGGACCAGCTGTGCTCTGCTCTCTGCTCCATGCTTTCAGGCCCAAAGACACTGGAGCGGCTCCGAGGCGCCCCAGAAGGCTTCTCCAGAACTGA CTTGCACCTGGCCGTGGTTCCAGTGCTGACAGCATTAATCTCTTACCATAACTACCTGGACAAAACCAAACAGCGCGAGATGGTCTACTGCCTGGAGCAG GGCCTCATCCACCGCTGTGCCAGCCAGTGCGTCGTGGCCTTGTCCATCTGCAGCGTGGAGATGCCTGACATCATCATCAAGGCGCTGCCTGTTCTGGTGG TGAAGCTCACGCACATCTCAGCCACAGCCAGCATGGCCGTCCCACTGCTGGAGTTCCTGTCCACTCTGGCCAGGCTGCCGCACCTCTACAGGAACTTTGC CGCGGAGCAGTATGCCAGTGTGTTCGCCATCTCCCTGCCGTACACCAACCCCTCCAAGTTTAATCAGTACATCGTGTGTCTGGCCCATCACGTCATAGCC ATGTGGTTCATCAGGTGCCGCCTGCCCTTCCGGAAGGATTTTGTCCCTTTCATCACTAAGGGCCTGCGGTCCAATGTCCTCTTGTCTTTTGATGACACCC CCGAGAAGGACAGCTTCAGGGCCCGGAGTACTAGTCTCAACGAGAGACCCAAGAGCAGGATACAGACGTCCCTCACCAGTGCCAGCTTGGGGTCTGCAGA TGAGAACTCCGTGGCCCAGGCTGACGATAGCCTGAAAAACCTCCACCTGGAGCTCACGGAAACCTGTCTGGACATGATGGCTCGATACGTCTTCTCCAAC TTCACGGCTGTCCCGAAGAGGTCTCCTGTGGGCGAGTTCCTCCTAGCGGGTGGCAGGACCAAAACCTGGCTGGTTGGGAACAAGCTTGTCACTGTGACGA CAAGCGTGGGAACCGGGACCCGGTCGTTACTAGGCCTGGACTCGGGGGAGCTGCAGTCCGGCCCGGAGTCGAGCTCCAGCCCCGGGGTGCATGTGAGACA GACCAAGGAGGCGCCGGCCAAGCTGGAGTCCCAGGCTGGGCAGCAGGTGTCCCGTGGGGCCCGGGATCGGGTCCGTTCCATGTCGGGGGGCCATGGTCTT CGAGTTGGCGCCCTGGACGTGCCGGCCTCCCAGTTCCTGGGCAGTGCCACTTCTCCAGGACCACGGACTGCACCAGCCGCGAAACCTGAGAAGGCCTCAG CTGGCACCCGGGTTCCTGTGCAGGAGAAGACGAACCTGGCGGCCTATGTGCCCCTGCTGACCCAGGGCTGGGCGGAGATCCTGGTCCGGAGGCCCACAGG GAACACCAGCTGGCTGATGAGCCTGGAGAACCCGCTCAGCCCTTTCTCCTCGGACATCAACAACATGCCCCTGCAGGAGCTGTCTAACGCCCTCATGGCG GCTGAGCGCTTCAAGGAGCACCGGGACACAGCCCTGTACAAGTCACTGTCGGTGCCGGCAGCCAGCACGGCCAAACCCCCTCCTCTGCCTCGCTCCAACA CAGTGGCCTCTTTCTCCTCCCTGTACCAGTCCAGCTGCCAAGGACAGCTGCACAGGAGCGTTTCCTGGGCAGACTCCGCCGTGGTCATGGAGGAGGGAAG TCCGGGCGAGGTTCCTGTGCTGGTGGAGCCCCCAGGGTTGGAGGACGTTGAGGCAGCGCTAGGCATGGACAGGCGCACGGATGCCTACAGCAGGTCGTCC TCAGTCTCCAGCCAGGAGGAGAAGTCGCTCCACGCGGAGGAGCTGGTTGGCAGGGGCATCCCCATCGAGCGAGTCGTCTCCTCGGAGGGTGGCCGGCCCT CTGTGGACCTCTCCTTCCAGCCCTCGCAGCCCCTGAGCAAGTCCAGCTCCTCTCCCGAGCTGCAGACTCTGCAGGACATCCTCGGGGACCCTGGGGACAA GGCCGACGTGGGCCGGCTGAGCCCTGAGGTTAAGGCCCGGTCACAGTCAGGGACCCTGGACGGGGAAAGTGCTGCCTGGTCGGCCTCGGGCGAAGACAGT CGGGGCCAGCCCGAGGGTCCCTTGCCTTCCAGCTCCCCCCGCTCGCCCAGTGGCCTCCGGCCCCGAGGTTACACCATCTCCGACTCGGCCCCATCACGCA GGGGCAAGAGAGTAGAGAGGGACGCCTTAAAGAGCAGAGCCACAGCCTCCAATGCAGAGAAAGTGCCAGGCATCAACCCCAGTTTCGTGTTCCTGCAGCT CTACCATTCCCCCTTCTTTGGCGACGAGTCAAACAAGCCAATCCTGCTGCCCAATGAGTCACAGTCCTTTGAGCGGTCGGTGCAGCTCCTCGACCAGATC CCATCATACGACACCCACAAGATCGCCGTCCTGTATGTTGGAGAAGGCCAGAGCAACAGCGAGCTCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGT ACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGCCGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGG CCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAG AAGCGCCACCTGGGCAACGACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACG TGATCGTCACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTC TGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCC TCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGCACCCTC CGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCTCGGTGGAGGACTTCAC CGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAAAGTCCTGACCCCAGTGCACAGACATA GAGGCACAGATTGC

refseq_TSC2.F2 (forward primer)
refseq_TSC2.R2 (reverse primer)
Single exon skipping

Frame 0

GASWSTMAKPTSKDSGLKEKFKILLGLGTPRPN PRSAEGKQTEFIITAEILRELSMECGLNNRIRMI GQICEVAKTKKFEEHAVEALWKAVADLLQPERP LEARHAVLALLKAIVQGQGERLGVLRALFFKVI KDYPSNEDLHERLEVFKALTDNGRHITYLEEELA DFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEY IARMVQMICLLCVRTASSVDIEVSLQVLDAVVC YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMR NLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRG AVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAM ACPNEVVSYEIVLSITRLIKKYRKELQVVAWDIL LNIIERLLQQLQTLDSPELRTIVHDLLTTVEEL CDQNEFHGSQERYFELVERCADQRPESSLLNLI SYRAQSIHPAKDGWIQNLQALMERFFRSESRGAV RIKVLDVLSFVLLINRQFYEEELINSVVISQLS HIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSL LDIIEKVMARSLSPPPELEERDVAAYSASLEDVK TAVLGLLVILQTKLYTLPASHATRVYEMLVSHI QLHYKHSYTLPIASSIRLQAFDFLLLLRADSLH RLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSG PLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLL QCLKQESDWKVLKLVLGRLPESLRYKVLIFTSP CSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTD LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQ GLIHRCASQCVVALSICSVEMPDIIIKALPVLV VKLTHISATASMAVPLLEFLSTLARLPHLYRNFA AEQYASVFAISLPYTNPSKFNQYIVCLAHHVIA MWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDT PEKDSFRARSTSLNERPKSRIQTSLTSASLGSAD ENSVAQADDSLKNLHLELTETCLDMMARYVFSN FTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVT TSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQ TKEAPAKLESQAGQQVSRGARDRVRSMSGGHGL RVGALDVPASQFLGSATSPGPRTAPAAKPEKAS AGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTG NTSWLMSLENPLSPFSSDINNMPLQELSNALMA AERFKEHRDTALYKSLSVPAASTAKPPPLPRSN TVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGS PGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSS SVSSQEEKSLHAEELVGRGIPIERVVSSEGGRP SVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDK ADVGRLSPEVKARSQSGTLDGESAAWSASGEDS RGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSR RGKRVERDALKSRATASNAEKVPGINPSFVFLQL YHSPFFGDESNKPILLPNESQSFERSVQLLDQI PSYDTHKIAVLYVGEGQSNSELAILSNEHGSYR YTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDG QFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDK KRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVH VIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVS DRNLPFVARQMALHANMASQVHHSRSNPTDIYP SKWIARLRHIKRLRQRICEEAAYSNPSLPLVHP PSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFT EFV*GRGPPSCTGLGRYCLSVK*IKS*PQCTDI EAQI

Frame 1

VRPGPPWPNQQAKIQA*RRSLRFCWDWEHRGQI PGLQRVNRRSLSSPRKY*EN*AWNVASTIASG* *GRFVKSQKPRNLKSTQWKHSGRRSRICCSRSGR WRPGTRCWLC*RPSCRGRASVWGSSEPSSLRSS RITLPTKTFTKGWRFSRPSQTMGDTSPTWRKSW LTLSCSGWMLACPRNSFWCW*TWSNSIAVTSTST SQGWFR*SVCCASGPRPLWT*RSPCRCWTPWSA TTACRLRASRCSSLPSVAPSTSRSSASLAGS*C GTSLAPTWATAPSTTCATSWRTEPTWRTRPC*EE PCFLWAWLSGEPTGSILSGTRRHLCCHHFTRPW HVRTRWCPMRSSCPSPGSSRSIGRSSRWWRGTF C*TSSNGSFSSSRPWTARSSGPSSMTC*PRWRSC VTRTSSTGLRRDTLNWWRDVRTRGLSPPS*T*S PIERSPSTRPRTAGFRTCRR*WRDSSGASPEAP CASRCWTCCPLCCSSTGSSMRRS*LTQWSSRSSP TSPRIKTTRSESWPPSCWWTWQRAATHTTSTAC WTSSRR*WPAPSPHPRSWKKGMWPHTRPPWRM* RQPSWGFWSSFRPSCTPCLQATPRVCMRCWSATF SSTTSTATPCQSRAASGCRPLTSCCCCGPTHCT AWACPTRMESCGSAPTASATTWSQREALRRRPA APFLLPQGLLARRLQAPPCGWGPCPTPCSSASCC SA*SRSLTGRC*SWFWAGCLSPCAIKCSSLLPL AVWTSCALLSAPCFQAQRHWSGSEAPQKASPEL TCTWPWFQC*QH*SLTITTWTKPNSARWSTAWSR ASSTAVPASASWPCPSAAWRCLTSSSRRCLFWW *SSRTSQPQPAWPSHCWSSCPLWPGCRTSTGTL PRSSMPVCSPSPCRTPTPPSLISTSCVWPITS*P CGSSGAACPSGRILSLSSLRACGPMSSCLLMTP PRRTASGPGVLVSTRDPRAGYRRPSPVPAWGLQ MRTPWPRLTIA*KTSTWSSRKPVWT*WLDTSSPT SRLSRRGLLWASSS*RVAGPKPGWLGTSLSL*R QAWEPGPGRY*AWTRGSCSPARSRAPAPGCM*D RPRRRRPSWSPRLGSRCPVGPGIGSVPCRGAMVF ELAPWTCRPPSSWAVPLLQDHGLHQPRNLRRPQ LAPGFLCRRRRTWRPMCPC*PRAGRRSWSGGPQ GTPAG**AWRTRSALSPRTSTTCPCRSCLTPSWR LSASRSTGTQPCTSHCRCRQPARPNPLLCLAPT QWPLSPPCTSPAAKDSCTGAFPGQTPPWSWRRE VRARFLCWWSPQGWRTLRQR*AWTGARMPTAGRP QSPARRRSRSTRRSWLAGASPSSESSPRRVAGP LWTSPSSPRSP*ASPAPLPSCRLCRTSSGTLGT RPTWAG*ALRLRPGHSQGPWTGKVLPGRPRAKTV GASPRVPCLPAPPARPVASGPEVTPSPTRPHHA GARE*RGTP*RAEPQPPMQRKCQASTPVSCSCS STIPPSLATSQTSQSCCPMSHSPLSGRCSSSTRS HHTTPTRSPSCMLEKARATASSPSCPMSMAPTG TRSS*RAWAGSSS*RTASRTRCTWEAWTCVVRT ASSPTAGTMTSCKPSSTSPP*CPPRTWTSTAATR SATWATTLCPLSTMTPVRTSSLAPSRASSTLST *SSPRWTTSATWCPCSAGKTWRALWTPAWPRSC LTATCPSWPARWPCTQIWPHRCIIAAPTPPISTP PSGLPGSATSSGSASGSARKPPTPTPAYLWCTL RPIAKPLHRLQPSPHLAMRWASGSASSPRWRTS PSLCEAGALPPALALDGIACQ*NK*SPDPSAQT* RHRL

Frame 2

CVLVHHGQTNKQRFRLEGEV*DSVGTGNTEAKS QVCRG*TDGVYHHRGNTERTEHGMWPQQSHPDD RADL*SRKNQEI*RARSGSTLEGGRGSVAAGAA AGGPARGAGSAEGHRAGAGRAFGGPQSPLL*GHQ GLPFQRRPSRKAGGFQGPHRQWETHHLLGGRAG *LCPAVDGCWLVLGIPSGAGELGQIQ*LLPRRV HRKDGSDDLSAVRPDRVLCGHRGLPAGAGRRGLL QLPAG*EPPAVHRYPLSHHQRQGALRALLEADA EPPWHPPGPQRHLQHVPPHGGQSLHGGRAPAER SRVFCGHGSLGSPPALFSQELADICVAIILPGHG MSERGGVL*DRPVHHQAHQEV*EGAPGGGVGHS AEHHRTAPSAAPDLGQPGAQDHRP*PVDHGGGA V*PERVPRVSGEIL*TGGEMCGPEA*VLPPEPDL L*SAVHPPGQGRLDSEPAGADGEILQERVPRRR AHQGAGRAVLCAAHQQAVL*GGAD*LSGHLAAL PHPRG*RPPGPKAGHPVAGGPGRGLPHTPLQQPA GHHREGDGPLPLPTPGAGRKGCGRILGLLGGCE DSRPGASGHPSDQAVHPACKPRHACV*DAGQPH SAPLQAQLHPANREQHPAAGL*LPVAAAGRLTAP PGPAQQGWSRAVQPLLRLRLHGARERL*EEDQR PPFSSHRASWPGACRPRRAAGVRALLPALPRPA AVLEAGV*LEGAEAGSGQAA*VPAL*SAHLYFPL QCGPAVLCSLLHAFRPKDTGAAPRRPRRLLQN* LAPGRGSSADSINLLP*LPGQNQTARDGLLPGA GPHPPLCQPVRRGLVHLQRGDA*HHHQGAACSGG EAHAHLSHSQHGRPTAGVPVHSGQAAAPLQELC RGAVCQCVRHLPAVHQPLQV*SVHRVSGPSRHS HVVHQVPPALPEGFCPFHH*GPAVQCPLVF**HP REGQLQGPEY*SQRETQEQDTDVPHQCQLGVCR *ELRGPG*R*PEKPPPGAHGNLSGHDGSIRLLQ LHGCPEEVSCGRVPPSGWQDQNLAGWEQACHCDD KRGNRDPVVTRPGLGGAAVRPGVELQPRGACET DQGGAGQAGVPGWAAGVPWGPGSGPFHVGGPWS SSWRPGRAGLPVPGQCHFSRTTDCTSRET*EGLS WHPGSCAGEDEPGGLCAPADPGLGGDPGPEAHR EHQLADEPGEPAQPFLLGHQQHAPAGAV*RPHG G*ALQGAPGHSPVQVTVGAGSQHGQTPSSASLQH SGLFLLPVPVQLPRTAAQERFLGRLRRGHGGGK SGRGSCAGGAPRVGGR*GSARHGQAHGCLQQVV LSLQPGGEVAPRGGAGWQGHPHRASRLLGGWPAL CGPLLPALAAPEQVQLLSRAADSAGHPRGPWGQ GRRGPAEP*G*GPVTVRDPGRGKCCLVGLGRRQ SGPARGSLAFQLPPLAQWPPAPRLHHLRLGPITQ GQESREGRLKEQSHSLQCRESARHQPQFRVPAA LPFPLLWRRVKQANPAAQ*VTVL*AVGAAPRPD PIIRHPQDRRPVCWRRPEQQRARHPVQ*AWLLQV HGVPDGPGPAHRAEGLPAGQGVPGRPGRVW*GR PVHLLLAR*HHASRLPHRHPDAHQGRGQAPLRQ EAPPGQRLCVHCLQ*LR*GLQAWHHQGPVQLCPR DRHPAGLRVQPGVPAVQERHGGPCGHQRGQDRV *PQPALRGPPDGPARKYGLTGAS*PLQPHRYLP LQVDCPAPPHQAAPPADLRGSRLLQPQPTSGAPS VP*QSPCTDSSRAHTWL*GGPAEAPHLLGGGLH RVCVRPGPSLLHWPWTVLPVSEINKVLTPVHRH RGTDC

Sequence NM_000548

GGTGCGTCCTGGTCCACCATGGCCAAACCAACAAGCAAAGATTCAGGCTTGAAGGAGAAGTTTAAGATTCTGTTGGGACTGGGAACACCGAGGCCAAATC CCAGGTCTGCAGAGGGTAAACAGACGGAGTTTATCATCACCGCGGAAATACTGAGAGAACTGAGCATGGAATGTGGCCTCAACAATCGCATCCGGATGAT AGGGCAGATTTGTGAAGTCGCAAAAACCAAGAAATTTGAAGAGCACGCAGTGGAAGCACTCTGGAAGGCGGTCGCGGATCTGTTGCAGCCGGAGCGGCCG CTGGAGGCCCGGCACGCGGTGCTGGCTCTGCTGAAGGCCATCGTGCAGGGGCAGGGCGAGCGTTTGGGGGTCCTCAGAGCCCTCTTCTTTAAGGTCATCA AGGATTACCCTTCCAACGAAGACCTTCACGAAAGGCTGGAGGTTTTCAAGGCCCTCACAGACAATGGGAGACACATCACCTACTTGGAGGAAGAGCTGGC TGACTTTGTCCTGCAGTGGATGGATGTTGGCTTGTCCTCGGAATTCCTTCTGGTGCTGGTGAACTTGGTCAAATTCAATAGCTGTTACCTCGACGAGTAC ATCGCAAGGATGGTTCAGATGATCTGTCTGCTGTGCGTCCGGACCGCGTCCTCTGTGGACATAGAGGTCTCCCTGCAGGTGCTGGACGCCGTGGTCTGCT ACAACTGCCTGCCGGCTGAGAGCCTCCCGCTGTTCATCGTTACCCTCTGTCGCACCATCAACGTCAAGGAGCTCTGCGAGCCTTGCTGGAAGCTGATGCG GAACCTCCTTGGCACCCACCTGGGCCACAGCGCCATCTACAACATGTGCCACCTCATGGAGGACAGAGCCTACATGGAGGACGCGCCCCTGCTGAGAGGA GCCGTGTTTTTTGTGGGCATGGCTCTCTGGGGAGCCCACCGGCTCTATTCTCTCAGGAACTCGCCGACATCTGTGTTGCCATCATTTTACCAGGCCATGG CATGTCCGAACGAGGTGGTGTCCTATGAGATCGTCCTGTCCATCACCAGGCTCATCAAGAAGTATAGGAAGGAGCTCCAGGTGGTGGCGTGGGACATTCT GCTGAACATCATCGAACGGCTCCTTCAGCAGCTCCAGACCTTGGACAGCCCGGAGCTCAGGACCATCGTCCATGACCTGTTGACCACGGTGGAGGAGCTG TGTGACCAGAACGAGTTCCACGGGTCTCAGGAGAGATACTTTGAACTGGTGGAGAGATGTGCGGACCAGAGGCCTGAGTCCTCCCTCCTGAACCTGATCT CCTATAGAGCGCAGTCCATCCACCCGGCCAAGGACGGCTGGATTCAGAACCTGCAGGCGCTGATGGAGAGATTCTTCAGGAGCGAGTCCCGAGGCGCCGT GCGCATCAAGGTGCTGGACGTGCTGTCCTTTGTGCTGCTCATCAACAGGCAGTTCTATGAGGAGGAGCTGATTAACTCAGTGGTCATCTCGCAGCTCTCC CACATCCCCGAGGATAAAGACCACCAGGTCCGAAAGCTGGCCACCCAGTTGCTGGTGGACCTGGCAGAGGGCTGCCACACACACCACTTCAACAGCCTGC TGGACATCATCGAGAAGGTGATGGCCCGCTCCCTCTCCCCACCCCCGGAGCTGGAAGAAAGGGATGTGGCCGCATACTCGGCCTCCTTGGAGGATGTGAA GACAGCCGTCCTGGGGCTTCTGGTCATCCTTCAGACCAAGCTGTACACCCTGCCTGCAAGCCACGCCACGCGTGTGTATGAGATGCTGGTCAGCCACATT CAGCTCCACTACAAGCACAGCTACACCCTGCCAATCGCGAGCAGCATCCGGCTGCAGGCCTTTGACTTCCTGTTGCTGCTGCGGGCCGACTCACTGCACC GCCTGGGCCTGCCCAACAAGGATGGAGTCGTGCGGTTCAGCCCCTACTGCGTCTGCGACTACATGGAGCCAGAGAGAGGCTCTGAGAAGAAGACCAGCGG CCCCCTTTCTCCTCCCACAGGGCCTCCTGGCCCGGCGCCTGCAGGCCCCGCCGTGCGGCTGGGGTCCGTGCCCTACTCCCTGCTCTTCCGCGTCCTGCTG CAGTGCTTGAAGCAGGAGTCTGACTGGAAGGTGCTGAAGCTGGTTCTGGGCAGGCTGCCTGAGTCCCTGCGCTATAAAGTGCTCATCTTTACTTCCCCTT GCAGTGTGGACCAGCTGTGCTCTGCTCTCTGCTCCATGCTTTCAGGCCCAAAGACACTGGAGCGGCTCCGAGGCGCCCCAGAAGGCTTCTCCAGAACTGA CTTGCACCTGGCCGTGGTTCCAGTGCTGACAGCATTAATCTCTTACCATAACTACCTGGACAAAACCAAACAGCGCGAGATGGTCTACTGCCTGGAGCAG GGCCTCATCCACCGCTGTGCCAGCCAGTGCGTCGTGGCCTTGTCCATCTGCAGCGTGGAGATGCCTGACATCATCATCAAGGCGCTGCCTGTTCTGGTGG TGAAGCTCACGCACATCTCAGCCACAGCCAGCATGGCCGTCCCACTGCTGGAGTTCCTGTCCACTCTGGCCAGGCTGCCGCACCTCTACAGGAACTTTGC CGCGGAGCAGTATGCCAGTGTGTTCGCCATCTCCCTGCCGTACACCAACCCCTCCAAGTTTAATCAGTACATCGTGTGTCTGGCCCATCACGTCATAGCC ATGTGGTTCATCAGGTGCCGCCTGCCCTTCCGGAAGGATTTTGTCCCTTTCATCACTAAGGGCCTGCGGTCCAATGTCCTCTTGTCTTTTGATGACACCC CCGAGAAGGACAGCTTCAGGGCCCGGAGTACTAGTCTCAACGAGAGACCCAAGAGTCTGAGGATAGCCAGACCCCCCAAACAAGGCTTGAATAACTCTCC ACCCGTGAAAGAATTCAAGGAGAGCTCTGCAGCCGAGGCCTTCCGGTGCCGCAGCATCAGTGTGTCTGAACATGTGGTCCGCAGCAGGATACAGACGTCC CTCACCAGTGCCAGCTTGGGGTCTGCAGATGAGAACTCCGTGGCCCAGGCTGACGATAGCCTGAAAAACCTCCACCTGGAGCTCACGGAAACCTGTCTGG ACATGATGGCTCGATACGTCTTCTCCAACTTCACGGCTGTCCCGAAGAGGTCTCCTGTGGGCGAGTTCCTCCTAGCGGGTGGCAGGACCAAAACCTGGCT GGTTGGGAACAAGCTTGTCACTGTGACGACAAGCGTGGGAACCGGGACCCGGTCGTTACTAGGCCTGGACTCGGGGGAGCTGCAGTCCGGCCCGGAGTCG AGCTCCAGCCCCGGGGTGCATGTGAGACAGACCAAGGAGGCGCCGGCCAAGCTGGAGTCCCAGGCTGGGCAGCAGGTGTCCCGTGGGGCCCGGGATCGGG TCCGTTCCATGTCGGGGGGCCATGGTCTTCGAGTTGGCGCCCTGGACGTGCCGGCCTCCCAGTTCCTGGGCAGTGCCACTTCTCCAGGACCACGGACTGC ACCAGCCGCGAAACCTGAGAAGGCCTCAGCTGGCACCCGGGTTCCTGTGCAGGAGAAGACGAACCTGGCGGCCTATGTGCCCCTGCTGACCCAGGGCTGG GCGGAGATCCTGGTCCGGAGGCCCACAGGGAACACCAGCTGGCTGATGAGCCTGGAGAACCCGCTCAGCCCTTTCTCCTCGGACATCAACAACATGCCCC TGCAGGAGCTGTCTAACGCCCTCATGGCGGCTGAGCGCTTCAAGGAGCACCGGGACACAGCCCTGTACAAGTCACTGTCGGTGCCGGCAGCCAGCACGGC CAAACCCCCTCCTCTGCCTCGCTCCAACACAGTGGCCTCTTTCTCCTCCCTGTACCAGTCCAGCTGCCAAGGACAGCTGCACAGGAGCGTTTCCTGGGCA GACTCCGCCGTGGTCATGGAGGAGGGAAGTCCGGGCGAGGTTCCTGTGCTGGTGGAGCCCCCAGGGTTGGAGGACGTTGAGGCAGCGCTAGGCATGGACA GGCGCACGGATGCCTACAGCAGGTCGTCCTCAGTCTCCAGCCAGGAGGAGAAGTCGCTCCACGCGGAGGAGCTGGTTGGCAGGGGCATCCCCATCGAGCG AGTCGTCTCCTCGGAGGGTGGCCGGCCCTCTGTGGACCTCTCCTTCCAGCCCTCGCAGCCCCTGAGCAAGTCCAGCTCCTCTCCCGAGCTGCAGACTCTG CAGGACATCCTCGGGGACCCTGGGGACAAGGCCGACGTGGGCCGGCTGAGCCCTGAGGTTAAGGCCCGGTCACAGTCAGGGACCCTGGACGGGGAAAGTG CTGCCTGGTCGGCCTCGGGCGAAGACAGTCGGGGCCAGCCCGAGGGTCCCTTGCCTTCCAGCTCCCCCCGCTCGCCCAGTGGCCTCCGGCCCCGAGGTTA CACCATCTCCGACTCGGCCCCATCACGCAGGGGCAAGAGAGTAGAGAGGGACGCCTTAAAGAGCAGAGCCACAGCCTCCAATGCAGAGAAAGTGCCAGGC ATCAACCCCAGTTTCGTGTTCCTGCAGCTCTACCATTCCCCCTTCTTTGGCGACGAGTCAAACAAGCCAATCCTGCTGCCCAATGAGTCACAGTCCTTTG AGCGGTCGGTGCAGCTCCTCGACCAGATCCCATCATACGACACCCACAAGATCGCCGTCCTGTATGTTGGAGAAGGCCAGAGCAACAGCGAGCTCGCCAT CCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGCCGGACAAGGTGTACCTG GGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCTTCCACATCGCCACCCTGATGCCCACCA AGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTGTCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCAC CATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACGAGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTT GTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGCCCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATA GCCGCTCCAACCCCACCGATATCTACCCCTCCAAGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTC CAACCCCAGCCTACCTCTGGTGCACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAG CGCCTCATCTCCTCGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAA TAAAGTCCTGACCCCAGTGCACAGACATAGAGGCACAGATTGC

refseq_TSC2.F2 (forward primer)
refseq_TSC2.R2 (reverse primer)
Single exon skipping

Frame 0

GASWSTMAKPTSKDSGLKEKFKILLGLGTPRPN PRSAEGKQTEFIITAEILRELSMECGLNNRIRMI GQICEVAKTKKFEEHAVEALWKAVADLLQPERP LEARHAVLALLKAIVQGQGERLGVLRALFFKVI KDYPSNEDLHERLEVFKALTDNGRHITYLEEELA DFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEY IARMVQMICLLCVRTASSVDIEVSLQVLDAVVC YNCLPAESLPLFIVTLCRTINVKELCEPCWKLMR NLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRG AVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAM ACPNEVVSYEIVLSITRLIKKYRKELQVVAWDIL LNIIERLLQQLQTLDSPELRTIVHDLLTTVEEL CDQNEFHGSQERYFELVERCADQRPESSLLNLI SYRAQSIHPAKDGWIQNLQALMERFFRSESRGAV RIKVLDVLSFVLLINRQFYEEELINSVVISQLS HIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSL LDIIEKVMARSLSPPPELEERDVAAYSASLEDVK TAVLGLLVILQTKLYTLPASHATRVYEMLVSHI QLHYKHSYTLPIASSIRLQAFDFLLLLRADSLH RLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSG PLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLL QCLKQESDWKVLKLVLGRLPESLRYKVLIFTSP CSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTD LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQ GLIHRCASQCVVALSICSVEMPDIIIKALPVLV VKLTHISATASMAVPLLEFLSTLARLPHLYRNFA AEQYASVFAISLPYTNPSKFNQYIVCLAHHVIA MWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDT PEKDSFRARSTSLNERPKSLRIARPPKQGLNNSP PVKEFKESSAAEAFRCRSISVSEHVVRSRIQTS LTSASLGSADENSVAQADDSLKNLHLELTETCL DMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWL VGNKLVTVTTSVGTGTRSLLGLDSGELQSGPES SSSPGVHVRQTKEAPAKLESQAGQQVSRGARDR VRSMSGGHGLRVGALDVPASQFLGSATSPGPRTA PAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGW AEILVRRPTGNTSWLMSLENPLSPFSSDINNMP LQELSNALMAAERFKEHRDTALYKSLSVPAASTA KPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWA DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIER VVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL QDILGDPGDKADVGRLSPEVKARSQSGTLDGES AAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGY TISDSAPSRRGKRVERDALKSRATASNAEKVPG INPSFVFLQLYHSPFFGDESNKPILLPNESQSF ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAI LSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYL GGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGT IKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGL VDTSVAKIVSDRNLPFVARQMALHANMASQVHH SRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYS NPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRK RLISSVEDFTEFV*GRGPPSCTGLGRYCLSVK* IKS*PQCTDIEAQI

Frame 1

VRPGPPWPNQQAKIQA*RRSLRFCWDWEHRGQI PGLQRVNRRSLSSPRKY*EN*AWNVASTIASG* *GRFVKSQKPRNLKSTQWKHSGRRSRICCSRSGR WRPGTRCWLC*RPSCRGRASVWGSSEPSSLRSS RITLPTKTFTKGWRFSRPSQTMGDTSPTWRKSW LTLSCSGWMLACPRNSFWCW*TWSNSIAVTSTST SQGWFR*SVCCASGPRPLWT*RSPCRCWTPWSA TTACRLRASRCSSLPSVAPSTSRSSASLAGS*C GTSLAPTWATAPSTTCATSWRTEPTWRTRPC*EE PCFLWAWLSGEPTGSILSGTRRHLCCHHFTRPW HVRTRWCPMRSSCPSPGSSRSIGRSSRWWRGTF C*TSSNGSFSSSRPWTARSSGPSSMTC*PRWRSC VTRTSSTGLRRDTLNWWRDVRTRGLSPPS*T*S PIERSPSTRPRTAGFRTCRR*WRDSSGASPEAP CASRCWTCCPLCCSSTGSSMRRS*LTQWSSRSSP TSPRIKTTRSESWPPSCWWTWQRAATHTTSTAC WTSSRR*WPAPSPHPRSWKKGMWPHTRPPWRM* RQPSWGFWSSFRPSCTPCLQATPRVCMRCWSATF SSTTSTATPCQSRAASGCRPLTSCCCCGPTHCT AWACPTRMESCGSAPTASATTWSQREALRRRPA APFLLPQGLLARRLQAPPCGWGPCPTPCSSASCC SA*SRSLTGRC*SWFWAGCLSPCAIKCSSLLPL AVWTSCALLSAPCFQAQRHWSGSEAPQKASPEL TCTWPWFQC*QH*SLTITTWTKPNSARWSTAWSR ASSTAVPASASWPCPSAAWRCLTSSSRRCLFWW *SSRTSQPQPAWPSHCWSSCPLWPGCRTSTGTL PRSSMPVCSPSPCRTPTPPSLISTSCVWPITS*P CGSSGAACPSGRILSLSSLRACGPMSSCLLMTP PRRTASGPGVLVSTRDPRV*G*PDPPNKA*ITL HP*KNSRRALQPRPSGAAASVCLNMWSAAGYRRP SPVPAWGLQMRTPWPRLTIA*KTSTWSSRKPVW T*WLDTSSPTSRLSRRGLLWASSS*RVAGPKPG WLGTSLSL*RQAWEPGPGRY*AWTRGSCSPARSR APAPGCM*DRPRRRRPSWSPRLGSRCPVGPGIG SVPCRGAMVFELAPWTCRPPSSWAVPLLQDHGL HQPRNLRRPQLAPGFLCRRRRTWRPMCPC*PRAG RRSWSGGPQGTPAG**AWRTRSALSPRTSTTCP CRSCLTPSWRLSASRSTGTQPCTSHCRCRQPAR PNPLLCLAPTQWPLSPPCTSPAAKDSCTGAFPGQ TPPWSWRREVRARFLCWWSPQGWRTLRQR*AWT GARMPTAGRPQSPARRRSRSTRRSWLAGASPSS ESSPRRVAGPLWTSPSSPRSP*ASPAPLPSCRLC RTSSGTLGTRPTWAG*ALRLRPGHSQGPWTGKV LPGRPRAKTVGASPRVPCLPAPPARPVASGPEV TPSPTRPHHAGARE*RGTP*RAEPQPPMQRKCQA STPVSCSCSSTIPPSLATSQTSQSCCPMSHSPL SGRCSSSTRSHHTTPTRSPSCMLEKARATASSP SCPMSMAPTGTRSS*RAWAGSSS*RTASRTRCTW EAWTCVVRTASSPTAGTMTSCKPSSTSPP*CPP RTWTSTAATRSATWATTLCPLSTMTPVRTSSLA PSRASSTLST*SSPRWTTSATWCPCSAGKTWRAL WTPAWPRSCLTATCPSWPARWPCTQIWPHRCII AAPTPPISTPPSGLPGSATSSGSASGSARKPPT PTPAYLWCTLRPIAKPLHRLQPSPHLAMRWASGS ASSPRWRTSPSLCEAGALPPALALDGIACQ*NK *SPDPSAQT*RHRL

Frame 2

CVLVHHGQTNKQRFRLEGEV*DSVGTGNTEAKS QVCRG*TDGVYHHRGNTERTEHGMWPQQSHPDD RADL*SRKNQEI*RARSGSTLEGGRGSVAAGAA AGGPARGAGSAEGHRAGAGRAFGGPQSPLL*GHQ GLPFQRRPSRKAGGFQGPHRQWETHHLLGGRAG *LCPAVDGCWLVLGIPSGAGELGQIQ*LLPRRV HRKDGSDDLSAVRPDRVLCGHRGLPAGAGRRGLL QLPAG*EPPAVHRYPLSHHQRQGALRALLEADA EPPWHPPGPQRHLQHVPPHGGQSLHGGRAPAER SRVFCGHGSLGSPPALFSQELADICVAIILPGHG MSERGGVL*DRPVHHQAHQEV*EGAPGGGVGHS AEHHRTAPSAAPDLGQPGAQDHRP*PVDHGGGA V*PERVPRVSGEIL*TGGEMCGPEA*VLPPEPDL L*SAVHPPGQGRLDSEPAGADGEILQERVPRRR AHQGAGRAVLCAAHQQAVL*GGAD*LSGHLAAL PHPRG*RPPGPKAGHPVAGGPGRGLPHTPLQQPA GHHREGDGPLPLPTPGAGRKGCGRILGLLGGCE DSRPGASGHPSDQAVHPACKPRHACV*DAGQPH SAPLQAQLHPANREQHPAAGL*LPVAAAGRLTAP PGPAQQGWSRAVQPLLRLRLHGARERL*EEDQR PPFSSHRASWPGACRPRRAAGVRALLPALPRPA AVLEAGV*LEGAEAGSGQAA*VPAL*SAHLYFPL QCGPAVLCSLLHAFRPKDTGAAPRRPRRLLQN* LAPGRGSSADSINLLP*LPGQNQTARDGLLPGA GPHPPLCQPVRRGLVHLQRGDA*HHHQGAACSGG EAHAHLSHSQHGRPTAGVPVHSGQAAAPLQELC RGAVCQCVRHLPAVHQPLQV*SVHRVSGPSRHS HVVHQVPPALPEGFCPFHH*GPAVQCPLVF**HP REGQLQGPEY*SQRETQESEDSQTPQTRLE*LS TRERIQGELCSRGLPVPQHQCV*TCGPQQDTDV PHQCQLGVCR*ELRGPG*R*PEKPPPGAHGNLSG HDGSIRLLQLHGCPEEVSCGRVPPSGWQDQNLA GWEQACHCDDKRGNRDPVVTRPGLGGAAVRPGV ELQPRGACETDQGGAGQAGVPGWAAGVPWGPGSG PFHVGGPWSSSWRPGRAGLPVPGQCHFSRTTDC TSRET*EGLSWHPGSCAGEDEPGGLCAPADPGL GGDPGPEAHREHQLADEPGEPAQPFLLGHQQHAP AGAV*RPHGG*ALQGAPGHSPVQVTVGAGSQHG QTPSSASLQHSGLFLLPVPVQLPRTAAQERFLG RLRRGHGGGKSGRGSCAGGAPRVGGR*GSARHGQ AHGCLQQVVLSLQPGGEVAPRGGAGWQGHPHRA SRLLGGWPALCGPLLPALAAPEQVQLLSRAADS AGHPRGPWGQGRRGPAEP*G*GPVTVRDPGRGKC CLVGLGRRQSGPARGSLAFQLPPLAQWPPAPRL HHLRLGPITQGQESREGRLKEQSHSLQCRESAR HQPQFRVPAALPFPLLWRRVKQANPAAQ*VTVL* AVGAAPRPDPIIRHPQDRRPVCWRRPEQQRARH PVQ*AWLLQVHGVPDGPGPAHRAEGLPAGQGVP GRPGRVW*GRPVHLLLAR*HHASRLPHRHPDAHQ GRGQAPLRQEAPPGQRLCVHCLQ*LR*GLQAWH HQGPVQLCPRDRHPAGLRVQPGVPAVQERHGGP CGHQRGQDRV*PQPALRGPPDGPARKYGLTGAS* PLQPHRYLPLQVDCPAPPHQAAPPADLRGSRLL QPQPTSGAPSVP*QSPCTDSSRAHTWL*GGPAE APHLLGGGLHRVCVRPGPSLLHWPWTVLPVSEIN KVLTPVHRHRGTDC