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Sequence NM_134259
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATTGGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCGGTGCGCCGGGCTCTTTTCGG
CCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGCCGCCACAGTTGCGCTGCTAGCGACGAGGTG
TTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTCCCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTT
GTAAGGTGCTAAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTGGATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAA
AGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGAGGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTC
CAGGAGTCAGGTTTTTCTCACTCGGCTTTCACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCA
TCTCCATTCTCCAGAAGGGACTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCT
GATAGTTGCTGTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCA
GCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAGAATGGAGCAC
ATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGGGGCCACGAGTCTGAGGTGTT
CATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGGAACCTGAATGAGAATAGCAACGGGGGCTCC
ACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAAGATGTCACCTCACTGGACTGGAACAGTGATGGAACACTAT
TGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGTAACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAA
ATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTAGACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTT
CATTCAGCCCCCGCCCTTGATGTGGACTGGCAGAACAACATGACCTTTGCCTCCTGTAGCACAGACATGTGTATCCATGTGTGCAGGCTCGGCTGTGACC
ACCCAGTCAAAACCTTCCAGGGACACACAAACGAGGTCAATGCCATCAAATGGGATCCTTCTGGAATGTTGCTGGCGTCCTGCTCGGATGACATGACATT
GAAGATCTGGAGTATGAAGCAGGATGCATGCGTCCACGATCTTCAGGCTCACAGCAAAGAGATCTACACCATCAAGTGGAGCCCCACCGGGCCTGCCACC
AGCAACCCAAACTCCAGCATCATGTTGGCAAGTGCTTCATTTGATTCTACAGTGCGACTGTGGGATGTGGAGCAAGGTGTCTGCACCCACACACTCATGA
AGCATCAAGAGCCTGTCTACAGTGTAGCTTTCAGCCCCGATGGAAAGTACTTGGCTAGTGGATCCTTTGACAAGTATGTTCATATCTGGAATACTCAGAG
TGGAAGTCTCGTCCACAGCTACCAAGGCACTGGCGGTATCTTCGAGGTGTGCTGGAACGCCCGAGGAGATAAAGTGGGCGCCAGCGCGTCTGATGGCTCT
GTGTGTGTTCTGGATCTGTGAAAGTAAACACAAAATATAGAAAAAAAGAAAAGAATTCTAATGACCTGCCTTGAATGCATGGGGTTGCAGCTCTGTTCAA
ACACAATTCTATCAGCTCCAAAATGTGTGAACTTGACTTGTGTTAGAGTATATTCTGAAACCAACTTGTCCCAGGCCACAGGAGTGTATATGTTTCATAA
TCTTTATCAAGA
- refseq_TBL1Y.F1 (forward primer)
- refseq_TBL1Y.R1 (reverse primer)
- Single exon skipping
Frame 0
PVPPIRARE*GAANTPAPLLPPPQCSLVAIGYLNFPVPATFPGLRGGGAEAAQGRHAAAPVRRALFG
RRTAGPHRLPS*ERLRTRPGTRRRHSCAASDEV
FSSAGTPESLVQPGRRGAGLPRQWPQCGIDVLG
CKVLRLVPTDGLPFL*LDAEKPAGSEVHT*SYHK
EGGSNFINTSSP*GEAKMSITSDEVNFLVYRYL
QESGFSHSAFTFGIESHISQSNINGTLVPPSAL
ISILQKGLQYVEAEISINKDGTVFDSRPIESLSL
IVAVIPDVVQMRQQAFGEKLTQQQASAAATEAS
AMAKAATMTPAAISQQNPPKNREATVNGEENGA
HEINNHSKPMEIDGDVEIPPNKATVLRGHESEVF
ICAWNPVSDLLASGSGDSTARIWNLNENSNGGS
TQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTL
LAMGSYDGFARIWTENGNLASTLGQHKGPIFALK
WNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPF
HSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD
HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL
KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT
SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLM
KHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQS
GSLVHSYQGTGGIFEVCWNARGDKVGASASDGS
VCVLDL*K*TQNIEKKKRILMTCLECMGLQLCS
NTILSAPKCVNLTCVRVYSETNLSQATGVYMFHN
LYQ
Frame 1
QCPQFALGSEEPPTPQLRCCRHRSAL*SPLVT*TFQYPRPFRDSAAAGQRRPRGGTRLLRCAGLFS
AAARPGLTGCPPERGSEHGQVRAAATVALLATRC
FPLLARQNPWFSLEGEGQDSPDSGLSVALMS*V
VRC*GWSPQTACHFYDWMLRSLLVQRSTHEVTI
KRVVPTSSIPHRHEVRLR*A*PVTR*TFWFIGIS
RSQVFLTRLSRLGSRATSASPTSMGH*CHRLPS
SPFSRRDCSM*RLR*ASTRMAQCSTAAL*SPCP
**LL*FLMWCRCGSRHLERSSLSSKPVQQPQRHQ
QWQRRQP*PQLLFPSKILQRTERPQ*TGKRMEH
MKSIITQSQWK*MGMLRFHPTKPQSFGATSLRC
SFVPGTLSVIC*PLDLETQLQGYGT*MRIATGAP
PSSC*DIVYEKGGTTSQVIKMSPHWTGTVMEHY
WLWVHMMVSQEYGQKMVTWPAP*ANIKAPSSL*
NGTKRGIMF*VLV*TKQQ*FGMLTQEKPNSSFLF
IQPPPLMWTGRTT*PLPPVAQTCVSMCAGSAVT
TQSKPSRDTQTRSMPSNGILLECCWRPARMT*H
*RSGV*SRMHASTIFRLTAKRSTPSSGAPPGLPP
ATQTPASCWQVLHLILQCDCGMWSKVSAPTHS*
SIKSLSTV*LSAPMESTWLVDPLTSMFISGILR
VEVSSTATKALAVSSRCAGTPEEIKWAPARLMAL
CVFWICESKHKI*KKRKEF**PALNAWGCSSVQ
TQFYQLQNV*T*LVLEYILKPTCPRPQECICFI
IFIK
Frame 2
SAPNSRSGVRSRQHPSSAAAATAVLSSRHWLPKLSSTRDLSGTPRRRGRGGPGAARGCSGAPGSFR
PPHGRASQAALLREAQNTARYAPPPQLRC*RRG
VFLCWHARIPGSAWKARGRTPQTVASVWH*CPRL
*GAKAGPHRRLAISMTGC*EACWFRGPHMKLP*
RGWFQLHQYLIAMR*G*DEHNQ*RGELSGLSVS
PGVRFFSLGFHVWDREPHQPVQHQWDTSATVCPH
LHSPEGTAVCRG*DKHQQGWHSVRQPPYRVPVP
DSCCDS*CGADAAAGIWREAHSAASQCSSHRGI
SNGKGGNHDPSCYFPAKSSKEPRGHSERGREWST
*NQ*SLKANGNRWGC*DSTQQSHSPSGPRV*GV
HLCLEPCQ*FASLWIWRLNCKDMEPE*E*QRGL
HPARVETLYTRRGARRPK**RCHLTGLEQ*WNTI
GYGFI*WFRKNMDRKW*PGQHLRPT*RPHLRSE
MEQKGELCFECWCRQNNNNLGCSHRRSQTAVSF
SFSPRP*CGLAEQHDLCLL*HRHVYPCVQARL*P
PSQNLPGTHKRGQCHQMGSFWNVAGVLLG*HDI
EDLEYEAGCMRPRSSGSQQRDLHHQVEPHRACH
QQPKLQHHVGKCFI*FYSATVGCGARCLHPHTHE
ASRACLQCSFQPRWKVLG*WIL*QVCSYLEYSE
WKSRPQLPRHWRYLRGVLERPRR*SGRQRV*WL
CVCSGSVKVNTKYRKKEKNSNDLP*MHGVAALFK
HNSISSKMCELDLC*SIF*NQLVPGHRSVYVS*
SLSR
Sequence NM_033284
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATTGGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCGGTGCGCCGGGCTCTTTTCGG
CCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGCCGCCACAGTTGCGCTGCTAGCGACGAGGTG
TTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTCCCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTT
GTAAGGTGCTAAGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTTTTGAAGAAATGAAGCAGGACTTGATGTGGATTGTCATAAACTGTTTCTCC
CTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTGGATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGG
GTGGTTCCAACTTCATCAATACCTCATCGCCATGAGGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGA
GTCAGGTTTTTCTCACTCGGCTTTCACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCC
ATTCTCCAGAAGGGACTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAG
TTGCTGTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCAGCAAT
GGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAGAATGGAGCACATGAA
ATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGGGGCCACGAGTCTGAGGTGTTCATTT
GTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGGAACCTGAATGAGAATAGCAACGGGGGCTCCACCCA
GCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAAGATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCT
ATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGTAACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGA
ACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTAGACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTC
AGCCCCCGCCCTTGATGTGGACTGGCAGAACAACATGACCTTTGCCTCCTGTAGCACAGACATGTGTATCCATGTGTGCAGGCTCGGCTGTGACCACCCA
GTCAAAACCTTCCAGGGACACACAAACGAGGTCAATGCCATCAAATGGGATCCTTCTGGAATGTTGCTGGCGTCCTGCTCGGATGACATGACATTGAAGA
TCTGGAGTATGAAGCAGGATGCATGCGTCCACGATCTTCAGGCTCACAGCAAAGAGATCTACACCATCAAGTGGAGCCCCACCGGGCCTGCCACCAGCAA
CCCAAACTCCAGCATCATGTTGGCAAGTGCTTCATTTGATTCTACAGTGCGACTGTGGGATGTGGAGCAAGGTGTCTGCACCCACACACTCATGAAGCAT
CAAGAGCCTGTCTACAGTGTAGCTTTCAGCCCCGATGGAAAGTACTTGGCTAGTGGATCCTTTGACAAGTATGTTCATATCTGGAATACTCAGAGTGGAA
GTCTCGTCCACAGCTACCAAGGCACTGGCGGTATCTTCGAGGTGTGCTGGAACGCCCGAGGAGATAAAGTGGGCGCCAGCGCGTCTGATGGCTCTGTGTG
TGTTCTGGATCTGTGAAAGTAAACACAAAATATAGAAAAAAAGAAAAGAATTCTAATGACCTGCCTTGAATGCATGGGGTTGCAGCTCTGTTCAAACACA
ATTCTATCAGCTCCAAAATGTGTGAACTTGACTTGTGTTAGAGTATATTCTGAAACCAACTTGTCCCAGGCCACAGGAGTGTATATGTTTCATAATCTTT
ATCAAGA
- refseq_TBL1Y.F1 (forward primer)
- refseq_TBL1Y.R1 (reverse primer)
- Single exon skipping
Frame 0
PVPPIRARE*GAANTPAPLLPPPQCSLVAIGYLNFPVPATFPGLRGGGAEAAQGRHAAAPVRRALFG
RRTAGPHRLPS*ERLRTRPGTRRRHSCAASDEV
FSSAGTPESLVQPGRRGAGLPRQWPQCGIDVLG
CKVLRGMPAVLLTEGQFLKK*SRT*CGLS*TVSP
*RGWSPQTACHFYDWMLRSLLVQRSTHEVTIKR
VVPTSSIPHRHEVRLR*A*PVTR*TFWFIGISR
SQVFLTRLSRLGSRATSASPTSMGH*CHRLPSSP
FSRRDCSM*RLR*ASTRMAQCSTAAL*SPCP**
LL*FLMWCRCGSRHLERSSLSSKPVQQPQRHQQ
WQRRQP*PQLLFPSKILQRTERPQ*TGKRMEHMK
SIITQSQWK*MGMLRFHPTKPQSFGATSLRCSF
VPGTLSVIC*PLDLETQLQGYGT*MRIATGAPP
SSC*DIVYEKGGTTSQVIKMSPHWTGTVMEHYWL
WVHMMVSQEYGQKMVTWPAP*ANIKAPSSL*NG
TKRGIMF*VLV*TKQQ*FGMLTQEKPNSSFLFI
QPPPLMWTGRTT*PLPPVAQTCVSMCAGSAVTTQ
SKPSRDTQTRSMPSNGILLECCWRPARMT*H*R
SGV*SRMHASTIFRLTAKRSTPSSGAPPGLPPA
TQTPASCWQVLHLILQCDCGMWSKVSAPTHS*SI
KSLSTV*LSAPMESTWLVDPLTSMFISGILRVE
VSSTATKALAVSSRCAGTPEEIKWAPARLMALC
VFWICESKHKI*KKRKEF**PALNAWGCSSVQTQ
FYQLQNV*T*LVLEYILKPTCPRPQECICFIIF
IK
Frame 1
QCPQFALGSEEPPTPQLRCCRHRSAL*SPLVT*TFQYPRPFRDSAAAGQRRPRGGTRLLRCAGLFS
AAARPGLTGCPPERGSEHGQVRAAATVALLATRC
FPLLARQNPWFSLEGEGQDSPDSGLSVALMS*V
VRC*GECQLFS*QKGSF*RNEAGLDVDCHKLFL
PKEAGPHRRLAISMTGC*EACWFRGPHMKLP*RG
WFQLHQYLIAMR*G*DEHNQ*RGELSGLSVSPG
VRFFSLGFHVWDREPHQPVQHQWDTSATVCPHL
HSPEGTAVCRG*DKHQQGWHSVRQPPYRVPVPDS
CCDS*CGADAAAGIWREAHSAASQCSSHRGISN
GKGGNHDPSCYFPAKSSKEPRGHSERGREWST*
NQ*SLKANGNRWGC*DSTQQSHSPSGPRV*GVHL
CLEPCQ*FASLWIWRLNCKDMEPE*E*QRGLHP
ARVETLYTRRGARRPK**RCHLTGLEQ*WNTIG
YGFI*WFRKNMDRKW*PGQHLRPT*RPHLRSEME
QKGELCFECWCRQNNNNLGCSHRRSQTAVSFSF
SPRP*CGLAEQHDLCLL*HRHVYPCVQARL*PP
SQNLPGTHKRGQCHQMGSFWNVAGVLLG*HDIED
LEYEAGCMRPRSSGSQQRDLHHQVEPHRACHQQ
PKLQHHVGKCFI*FYSATVGCGARCLHPHTHEA
SRACLQCSFQPRWKVLG*WIL*QVCSYLEYSEWK
SRPQLPRHWRYLRGVLERPRR*SGRQRV*WLCV
CSGSVKVNTKYRKKEKNSNDLP*MHGVAALFKH
NSISSKMCELDLC*SIF*NQLVPGHRSVYVS*SL
SR
Frame 2
SAPNSRSGVRSRQHPSSAAAATAVLSSRHWLPKLSSTRDLSGTPRRRGRGGPGAARGCSGAPGSFR
PPHGRASQAALLREAQNTARYAPPPQLRC*RRG
VFLCWHARIPGSAWKARGRTPQTVASVWH*CPRL
*GAKGNASCSLNRRAVFEEMKQDLMWIVINCFS
LKRLVPTDGLPFL*LDAEKPAGSEVHT*SYHKE
GGSNFINTSSP*GEAKMSITSDEVNFLVYRYLQE
SGFSHSAFTFGIESHISQSNINGTLVPPSALIS
ILQKGLQYVEAEISINKDGTVFDSRPIESLSLI
VAVIPDVVQMRQQAFGEKLTQQQASAAATEASAM
AKAATMTPAAISQQNPPKNREATVNGEENGAHE
INNHSKPMEIDGDVEIPPNKATVLRGHESEVFI
CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQ
LVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLA
MGSYDGFARIWTENGNLASTLGQHKGPIFALKW
NKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHS
APALDVDWQNNMTFASCSTDMCIHVCRLGCDHP
VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK
IWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN
PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH
QEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG
SLVHSYQGTGGIFEVCWNARGDKVGASASDGSVC
VLDL*K*TQNIEKKKRILMTCLECMGLQLCSNT
ILSAPKCVNLTCVRVYSETNLSQATGVYMFHNL
YQ
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