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Sequences

Sequence NM_001018056

CTCTCCGGCCGCCGCCGGTGCGGGTGCTCCGCTACCGGCTCCTCTCCGTTCTGTGCTCTCTTCTGCTCTCGGCTCCCCACCCCCTCTCCCTTCCCTCCTC TCCCCTTGCCTCCCCTCCTCTGCAGCGCCTGCATTATTTTCTGCCCGCAGGCTCGGCTTGCACTGCTGCTGCAGCCCGGGGAGGTGGCTGGGTGGGTGGG GAGGAGACTGTGCAAGTTGTAGGGGAGGGGGTGCCCTCTTCTTCCCCGCTCCCTTCCCCCGCCAACTCCTTCCCCTCCTTCTCCCCCTTTCCCCTCCCCG CCCCCACCTTCTTCCTCCTTTCGGAAGGACTGGTAACTTGTCGTGCGGAGCGAACGGCGGCGGCGGCGGCGGCGGCGGCACCATCCAGGCGGGCACCATG GGCACGTCCGCGCTCTGGGCGCTCTGGCTGCTGCTCGCGCTGTGCTGGGCGCCCCGGGAGAGCGGCGCCACCGGAACCGGGAGAAAAGCCAAATGTGAAC CCTCCCAATTCCAGTGCACAAATGGTCGCTGTATTACGCTGTTGTGGAAATGTGATGGGGATGAAGACTGTGTTGACGGCAGTGATGAAAAGAACTGTGT AAAGAAGACGTGTGCTGAATCTGACTTCGTGTGCAACAATGGCCAGTGTGTTCCCAGCCGATGGAAGTGTGATGGAGATCCTGACTGCGAAGATGGTTCA GATGAAAGCCCAGAACAGTGCCATATGAGAACATGCCGCATACATGAAATCAGCTGTGGCGCCCATTCTACTCAGTGTATCCCAGTGTCCTGGAGATGTG ATGGTGAAAATGATTGTGACAGTGGAGAAGATGAAGAAAACTGTGGCAATATAACATGTAGTCCCGACGAGTTCACCTGCTCCAGTGGCCGCTGCATCTC CAGGAACTTTGTATGCAATGGCCAGGATGACTGCAGCGATGGCAGTGATGAGCTGGACTGTGCCCCGCCAACCTGTGGCGCCCATGAGTTCCAGTGCAGC ACCTCCTCCTGCATCCCCATCAGCTGGGTATGCGACGATGATGCAGACTGCTCCGACCAATCTGATGAGTCCCTGGAGCAGTGTGGCCGTCAGCCAGTCA TACACACCAAGTGTCCAGCCAGCGAAATCCAGTGCGGCTCTGGCGAGTGCATCCATAAGAAGTGGCGATGTGATGGGGACCCTGACTGCAAGGATGGCAG TGATGAGGTCAACTGTCCCTCTCGAACTTGCCGACCTGACCAATTTGAATGTGAGGATGGCAGCTGCATCCATGGCAGCAGGCAGTGTAATGGTATCCGA GACTGTGTCGATGGTTCCGATGAAGTCAACTGCAAAAATGTCAATCAGTGCTTGGGCCCTGGAAAATTCAAGTGCAGAAGTGGAGAATGCATAGATATCA GCAAAGTATGTAACCAGGAGCAGGACTGCAGGGACTGGAGTGATGAGCCCCTGAAAGAGTGTCATATAAACGAATGCTTGGTAAATAATGGTGGATGTTC TCATATCTGCAAAGACCTAGTTATAGGCTACGAGTGTGACTGTGCAGCTGGGTTTGAACTGATAGATAGGAAAACCTGTGGAGATATTGATGAATGCCAA AATCCAGGAATCTGCAGTCAAATTTGTATCAACTTAAAAGGCGGTTACAAGTGTGAATGTAGTCGTGGCTATCAAATGGATCTTGCTACTGGCGTGTGCA AGGCAGTAGGCAAAGAGCCAAGTCTGATCTTCACTAATCGAAGAGACATCAGGAAGATTGGCTTAGAGAGGAAAGAATATATCCAACTAGTTGAACAGCT AAGAAACACTGTGGCTCTCGATGCTGACATTGCTGCCCAGAAACTATTCTGGGCCGATCTAAGCCAAAAGGCTATCTTCAGTGCCTCAATTGATGACAAG GTTGGTAGACATGTTAAAATGATCGACAATGTCTATAATCCTGCAGCCATTGCTGTTGATTGGGTGTACAAGACCATCTACTGGACTGATGCGGCTTCTA AGACTATTTCAGTAGCTACCCTAGATGGAACCAAGAGGAAGTTCCTGTTTAACTCTGACTTGCGAGAGCCTGCCTCCATAGCTGTGGACCCACTGTCTGG CTTTGTTTACTGGTCAGACTGGGGTGAACCAGCTAAAATAGAAAAAGCAGGAATGAATGGATTCGATAGACGTCCACTGGTGACAGCGGATATCCAGTGG CCTAACGGAATTACACTTGACCTTATAAAAAGTCGCCTCTATTGGCTTGATTCTAAGTTGCACATGTTATCCAGCGTGGACTTGAATGGCCAAGATCGTA GGATAGTACTAAAGTCTCTGGAGTTCCTAGCTCATCCTCTTGCACTAACAATATTTGAGGATCGTGTCTACTGGATAGATGGGGAAAATGAAGCAGTCTA TGGTGCCAATAAATTCACTGGATCAGAGCTAGCCACTCTAGTCAACAACCTGAATGATGCCCAAGACATCATTGTCTATCATGAACTTGTACAGCCATCA GGTAAAAATTGGTGTGAAGAAGACATGGAGAATGGAGGATGTGAATACCTATGCCTGCCAGCACCACAGATTAATGATCACTCTCCAAAATATACCTGTT CCTGTCCCAGTGGGTACAATGTAGAGGAAAATGGCCGAGACTGTCAAAGGATCAATGTGACCACAGCAGTATCAGAGGTCAGTGTTCCCCCAAAAGGGAC TTCTGCCGCATGGGCCATTCTTCCTCTCTTGCTCTTAGTGATGGCAGCAGTAGGTGGCTACTTGATGTGGCGGAATTGGCAACACAAGAACATGAAAAGC ATGAACTTTGACAATCCTGTGTACTTGAAAACCACTGAAGAGGACCTCTCCATAGACATTGGTAGACACAGTGCTTCTGTTGGACACACGTACCCAGCAA TATCAGTTGTAAGCACAGATGATGATCTAGCTTGACTTCTGTGACAAATGTTGACCTTTGAGGTCTAAACAAATAATACCCCCGTCGGAATGGTAACCGA GCCAGCAGCTGAAGTCTCTTTTTCTTCCTCTCGGCTGGAAGAACATCAAGATACCTTTGCGTGGATCAAGCTTGTGTACTTGACCGTTTTTATATTACTT TTGTAAATATTCTTGTCCACATTCTACTTCAGCTTTGGATGTGGTTACCGAGTATCTGTAACCCTTGAATTTCTAGACAGTATTGCCACCTCTGGCCAAA TATGCACTTTCCCTAGAAAGCCATATTCCAGCAGTGAAACTTGTGCTATAGTGTATACCACCTGTACATACATTGTATAGGCCATCTGTAAATATCCCAG AGAACAATCACTATTCTTAAGCACTTTGAAAATATTTCTATGTAAATTATTGTAAACTTTTTCAATGGTTGGGACAATGGCAATAGGACAAAACGGGTTA CTAAGATGAAATTGCCAAAAAAATTTATAAACTAATTTTGTACGTATGAATGATATCTTTGACCTCAATGGAGGTTTGCAAAGACTGAGTGTTCAAACTA CTGTACATTTTTTTTCAAGTGCTAAAAAATTAAACCAAGCAGCTTAACCATG

refseq_VLDLR.F1 (forward primer)
refseq_VLDLR.R1 (reverse primer)
Single exon skipping

Frame 0

LSGRRRCGCSATGSSPFCALFCSRLPTPSPFPP LPLPPLLCSACIIFCPQARLALLLQPGEVAGWVG RRLCKL*GRGCPLLPRSLPPPTPSPPSPPFPSP PPPSSSFRKDW*LVVRSERRRRRRRRHHPGGHH GHVRALGALAAARAVLGAPGERRHRNREKSQM*T LPIPVHKWSLYYAVVEM*WG*RLC*RQ**KELC KEDVC*I*LRVQQWPVCSQPMEV*WRS*LRRWF R*KPRTVPYENMPHT*NQLWRPFYSVYPSVLEM* W*K*L*QWRR*RKLWQYNM*SRRVHLLQWPLHL QELCMQWPG*LQRWQ**AGLCPANLWRP*VPVQ HLLLHPHQLGMRR*CRLLRPI**VPGAVWPSASH THQVSSQRNPVRLWRVHP*EVAM*WGP*LQGWQ **GQLSLSNLPT*PI*M*GWQLHPWQQAV*WYP RLCRWFR*SQLQKCQSVLGPWKIQVQKWRMHRYQ QSM*PGAGLQGLE**APERVSYKRMLGK*WWMF SYLQRPSYRLRV*LCSWV*TDR*ENLWRY**MP KSRNLQSNLYQLKRRLQV*M*SWLSNGSCYWRVQ GSRQRAKSDLH*SKRHQEDWLREERIYPTS*TA KKHCGSRC*HCCPETILGRSKPKGYLQCLN**Q GW*TC*NDRQCL*SCSHCC*LGVQDHLLD*CGF* DYFSSYPRWNQEEVPV*L*LARACLHSCGPTVW LCLLVRLG*TS*NRKSRNEWIR*TSTGDSGYPV A*RNYT*PYKKSPLLA*F*VAHVIQRGLEWPRS* DSTKVSGVPSSSSCTNNI*GSCLLDRWGK*SSL WCQ*IHWIRASHSSQQPE*CPRHHCLS*TCTAI R*KLV*RRHGEWRM*IPMPASTTD**SLSKIYLF LSQWVQCRGKWPRLSKDQCDHSSIRGQCSPKRD FCRMGHSSSLALSDGSSRWLLDVAELATQEHEK HEL*QSCVLENH*RGPLHRHW*TQCFCWTHVPSN ISCKHR**SSLTSVTNVDL*GLNK*YPRRNGNR ASS*SLFFFLSAGRTSRYLCVDQACVLDRFYIT FVNILVHILLQLWMWLPSICNP*ISRQYCHLWPN MHFP*KAIFQQ*NLCYSVYHLYIHCIGHL*ISQ RTITILKHFENISM*IIVNFFNGWDNGNRTKRV TKMKLPKKFIN*FCTYE*YL*PQWRFAKTECSNY CTFFFKC*KIKPSSLTM

Frame 1

SPAAAGAGAPLPAPLRSVLSSALGSPPPLPSLL SPCLPSSAAPALFSARRLGLHCCCSPGRWLGGW GGDCASCRGGGALFFPAPFPRQLLPLLLPLSPPR PHLLPPFGRTGNLSCGANGGGGGGGGTIQAGTM GTSALWALWLLLALCWAPRESGATGTGRKAKCE PSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV KKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGS DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC DGENDCDSGEDEENCGNITCSPDEFTCSSGRCIS RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS TSSCIPISWVCDDDADCSDQSDESLEQCGRQPV IHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIR DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS HICKDLVIGYECDCAAGFELIDRKTCGDIDECQ NPGICSQICINLKGGYKCECSRGYQMDLATGVC KAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL RNTVALDADIAAQKLFWADLSQKAIFSASIDDK VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS KTISVATLDGTKRKFLFNSDLREPASIAVDPLSG FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQW PNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVY GANKFTGSELATLVNNLNDAQDIIVYHELVQPS GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTC SCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGT SAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKS MNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPA ISVVSTDDDLA*LL*QMLTFEV*TNNTPVGMVTE PAAEVSFSSSRLEEHQDTFAWIKLVYLTVFILL L*IFLSTFYFSFGCGYRVSVTLEFLDSIATSGQ ICTFPRKPYSSSETCAIVYTTCTYIV*AICKYPR EQSLFLSTLKIFLCKLL*TFSMVGTMAIGQNGL LR*NCQKNL*TNFVRMNDIFDLNGGLQRLSVQT TVHFFSSAKKLNQAA*P

Frame 2

LRPPPVRVLRYRLLSVLCSLLLSAPHPLSLPSS PLASPPLQRLHYFLPAGSACTAAAARGGGWVGG EETVQVVGEGVPSSSPLPSPANSFPSFSPFPLP APTFFLLSEGLVTCRAERTAAAAAAAAPSRRAPW ARPRSGRSGCCSRCAGRPGRAAPPEPGEKPNVN PPNSSAQMVAVLRCCGNVMGMKTVLTAVMKRTV *RRRVLNLTSCATMASVFPADGSVMEILTAKMVQ MKAQNSAI*EHAAYMKSAVAPILLSVSQCPGDV MVKMIVTVEKMKKTVAI*HVVPTSSPAPVAAAS PGTLYAMARMTAAMAVMSWTVPRQPVAPMSSSAA PPPASPSAGYATMMQTAPTNLMSPWSSVAVSQS YTPSVQPAKSSAALASASIRSGDVMGTLTARMA VMRSTVPLELADLTNLNVRMAAASMAAGSVMVSE TVSMVPMKSTAKMSISAWALENSSAEVENA*IS AKYVTRSRTAGTGVMSP*KSVI*TNAW*IMVDV LISAKT*L*ATSVTVQLGLN**IGKPVEILMNAK IQESAVKFVST*KAVTSVNVVVAIKWILLLACA RQ*AKSQV*SSLIEETSGRLA*RGKNISN*LNS *ETLWLSMLTLLPRNYSGPI*AKRLSSVPQLMTR LVDMLK*STMSIILQPLLLIGCTRPSTGLMRLL RLFQ*LP*MEPRGSSCLTLTCESLPP*LWTHCL ALFTGQTGVNQLK*KKQE*MDSIDVHW*QRISSG LTELHLTL*KVASIGLILSCTCYPAWT*MAKIV G*Y*SLWSS*LILLH*QYLRIVSTG*MGKMKQS MVPINSLDQS*PL*STT*MMPKTSLSIMNLYSHQ VKIGVKKTWRMEDVNTYACQHHRLMITLQNIPV PVPVGTM*RKMAETVKGSM*PQQYQRSVFPQKG LLPHGPFFLSCS**WQQ*VAT*CGGIGNTRT*KA *TLTILCT*KPLKRTSP*TLVDTVLLLDTRTQQ YQL*AQMMI*LDFCDKC*PLRSKQIIPPSEW*P SQQLKSLFLPLGWKNIKIPLRGSSLCT*PFLYYF CKYSCPHSTSALDVVTEYL*PLNF*TVLPPLAK YALSLESHIPAVKLVL*CIPPVHTLYRPSVNIP ENNHYS*AL*KYFYVNYCKLFQWLGQWQ*DKTGY *DEIAKKIYKLILYV*MISLTSMEVCKD*VFKL LYIFFQVLKN*TKQLNH

Sequence NM_003383

CTCTCCGGCCGCCGCCGGTGCGGGTGCTCCGCTACCGGCTCCTCTCCGTTCTGTGCTCTCTTCTGCTCTCGGCTCCCCACCCCCTCTCCCTTCCCTCCTC TCCCCTTGCCTCCCCTCCTCTGCAGCGCCTGCATTATTTTCTGCCCGCAGGCTCGGCTTGCACTGCTGCTGCAGCCCGGGGAGGTGGCTGGGTGGGTGGG GAGGAGACTGTGCAAGTTGTAGGGGAGGGGGTGCCCTCTTCTTCCCCGCTCCCTTCCCCCGCCAACTCCTTCCCCTCCTTCTCCCCCTTTCCCCTCCCCG CCCCCACCTTCTTCCTCCTTTCGGAAGGACTGGTAACTTGTCGTGCGGAGCGAACGGCGGCGGCGGCGGCGGCGGCGGCACCATCCAGGCGGGCACCATG GGCACGTCCGCGCTCTGGGCGCTCTGGCTGCTGCTCGCGCTGTGCTGGGCGCCCCGGGAGAGCGGCGCCACCGGAACCGGGAGAAAAGCCAAATGTGAAC CCTCCCAATTCCAGTGCACAAATGGTCGCTGTATTACGCTGTTGTGGAAATGTGATGGGGATGAAGACTGTGTTGACGGCAGTGATGAAAAGAACTGTGT AAAGAAGACGTGTGCTGAATCTGACTTCGTGTGCAACAATGGCCAGTGTGTTCCCAGCCGATGGAAGTGTGATGGAGATCCTGACTGCGAAGATGGTTCA GATGAAAGCCCAGAACAGTGCCATATGAGAACATGCCGCATACATGAAATCAGCTGTGGCGCCCATTCTACTCAGTGTATCCCAGTGTCCTGGAGATGTG ATGGTGAAAATGATTGTGACAGTGGAGAAGATGAAGAAAACTGTGGCAATATAACATGTAGTCCCGACGAGTTCACCTGCTCCAGTGGCCGCTGCATCTC CAGGAACTTTGTATGCAATGGCCAGGATGACTGCAGCGATGGCAGTGATGAGCTGGACTGTGCCCCGCCAACCTGTGGCGCCCATGAGTTCCAGTGCAGC ACCTCCTCCTGCATCCCCATCAGCTGGGTATGCGACGATGATGCAGACTGCTCCGACCAATCTGATGAGTCCCTGGAGCAGTGTGGCCGTCAGCCAGTCA TACACACCAAGTGTCCAGCCAGCGAAATCCAGTGCGGCTCTGGCGAGTGCATCCATAAGAAGTGGCGATGTGATGGGGACCCTGACTGCAAGGATGGCAG TGATGAGGTCAACTGTCCCTCTCGAACTTGCCGACCTGACCAATTTGAATGTGAGGATGGCAGCTGCATCCATGGCAGCAGGCAGTGTAATGGTATCCGA GACTGTGTCGATGGTTCCGATGAAGTCAACTGCAAAAATGTCAATCAGTGCTTGGGCCCTGGAAAATTCAAGTGCAGAAGTGGAGAATGCATAGATATCA GCAAAGTATGTAACCAGGAGCAGGACTGCAGGGACTGGAGTGATGAGCCCCTGAAAGAGTGTCATATAAACGAATGCTTGGTAAATAATGGTGGATGTTC TCATATCTGCAAAGACCTAGTTATAGGCTACGAGTGTGACTGTGCAGCTGGGTTTGAACTGATAGATAGGAAAACCTGTGGAGATATTGATGAATGCCAA AATCCAGGAATCTGCAGTCAAATTTGTATCAACTTAAAAGGCGGTTACAAGTGTGAATGTAGTCGTGGCTATCAAATGGATCTTGCTACTGGCGTGTGCA AGGCAGTAGGCAAAGAGCCAAGTCTGATCTTCACTAATCGAAGAGACATCAGGAAGATTGGCTTAGAGAGGAAAGAATATATCCAACTAGTTGAACAGCT AAGAAACACTGTGGCTCTCGATGCTGACATTGCTGCCCAGAAACTATTCTGGGCCGATCTAAGCCAAAAGGCTATCTTCAGTGCCTCAATTGATGACAAG GTTGGTAGACATGTTAAAATGATCGACAATGTCTATAATCCTGCAGCCATTGCTGTTGATTGGGTGTACAAGACCATCTACTGGACTGATGCGGCTTCTA AGACTATTTCAGTAGCTACCCTAGATGGAACCAAGAGGAAGTTCCTGTTTAACTCTGACTTGCGAGAGCCTGCCTCCATAGCTGTGGACCCACTGTCTGG CTTTGTTTACTGGTCAGACTGGGGTGAACCAGCTAAAATAGAAAAAGCAGGAATGAATGGATTCGATAGACGTCCACTGGTGACAGCGGATATCCAGTGG CCTAACGGAATTACACTTGACCTTATAAAAAGTCGCCTCTATTGGCTTGATTCTAAGTTGCACATGTTATCCAGCGTGGACTTGAATGGCCAAGATCGTA GGATAGTACTAAAGTCTCTGGAGTTCCTAGCTCATCCTCTTGCACTAACAATATTTGAGGATCGTGTCTACTGGATAGATGGGGAAAATGAAGCAGTCTA TGGTGCCAATAAATTCACTGGATCAGAGCTAGCCACTCTAGTCAACAACCTGAATGATGCCCAAGACATCATTGTCTATCATGAACTTGTACAGCCATCA GGTAAAAATTGGTGTGAAGAAGACATGGAGAATGGAGGATGTGAATACCTATGCCTGCCAGCACCACAGATTAATGATCACTCTCCAAAATATACCTGTT CCTGTCCCAGTGGGTACAATGTAGAGGAAAATGGCCGAGACTGTCAAAGTACTGCAACTACTGTGACTTACAGTGAGACAAAAGATACGAACACAACAGA AATTTCAGCAACTAGTGGACTAGTTCCTGGAGGGATCAATGTGACCACAGCAGTATCAGAGGTCAGTGTTCCCCCAAAAGGGACTTCTGCCGCATGGGCC ATTCTTCCTCTCTTGCTCTTAGTGATGGCAGCAGTAGGTGGCTACTTGATGTGGCGGAATTGGCAACACAAGAACATGAAAAGCATGAACTTTGACAATC CTGTGTACTTGAAAACCACTGAAGAGGACCTCTCCATAGACATTGGTAGACACAGTGCTTCTGTTGGACACACGTACCCAGCAATATCAGTTGTAAGCAC AGATGATGATCTAGCTTGACTTCTGTGACAAATGTTGACCTTTGAGGTCTAAACAAATAATACCCCCGTCGGAATGGTAACCGAGCCAGCAGCTGAAGTC TCTTTTTCTTCCTCTCGGCTGGAAGAACATCAAGATACCTTTGCGTGGATCAAGCTTGTGTACTTGACCGTTTTTATATTACTTTTGTAAATATTCTTGT CCACATTCTACTTCAGCTTTGGATGTGGTTACCGAGTATCTGTAACCCTTGAATTTCTAGACAGTATTGCCACCTCTGGCCAAATATGCACTTTCCCTAG AAAGCCATATTCCAGCAGTGAAACTTGTGCTATAGTGTATACCACCTGTACATACATTGTATAGGCCATCTGTAAATATCCCAGAGAACAATCACTATTC TTAAGCACTTTGAAAATATTTCTATGTAAATTATTGTAAACTTTTTCAATGGTTGGGACAATGGCAATAGGACAAAACGGGTTACTAAGATGAAATTGCC AAAAAAATTTATAAACTAATTTTGTACGTATGAATGATATCTTTGACCTCAATGGAGGTTTGCAAAGACTGAGTGTTCAAACTACTGTACATTTTTTTTC AAGTGCTAAAAAATTAAACCAAGCAGCTTAACCATG

refseq_VLDLR.F1 (forward primer)
refseq_VLDLR.R1 (reverse primer)
Single exon skipping

Frame 0

LSGRRRCGCSATGSSPFCALFCSRLPTPSPFPP LPLPPLLCSACIIFCPQARLALLLQPGEVAGWVG RRLCKL*GRGCPLLPRSLPPPTPSPPSPPFPSP PPPSSSFRKDW*LVVRSERRRRRRRRHHPGGHH GHVRALGALAAARAVLGAPGERRHRNREKSQM*T LPIPVHKWSLYYAVVEM*WG*RLC*RQ**KELC KEDVC*I*LRVQQWPVCSQPMEV*WRS*LRRWF R*KPRTVPYENMPHT*NQLWRPFYSVYPSVLEM* W*K*L*QWRR*RKLWQYNM*SRRVHLLQWPLHL QELCMQWPG*LQRWQ**AGLCPANLWRP*VPVQ HLLLHPHQLGMRR*CRLLRPI**VPGAVWPSASH THQVSSQRNPVRLWRVHP*EVAM*WGP*LQGWQ **GQLSLSNLPT*PI*M*GWQLHPWQQAV*WYP RLCRWFR*SQLQKCQSVLGPWKIQVQKWRMHRYQ QSM*PGAGLQGLE**APERVSYKRMLGK*WWMF SYLQRPSYRLRV*LCSWV*TDR*ENLWRY**MP KSRNLQSNLYQLKRRLQV*M*SWLSNGSCYWRVQ GSRQRAKSDLH*SKRHQEDWLREERIYPTS*TA KKHCGSRC*HCCPETILGRSKPKGYLQCLN**Q GW*TC*NDRQCL*SCSHCC*LGVQDHLLD*CGF* DYFSSYPRWNQEEVPV*L*LARACLHSCGPTVW LCLLVRLG*TS*NRKSRNEWIR*TSTGDSGYPV A*RNYT*PYKKSPLLA*F*VAHVIQRGLEWPRS* DSTKVSGVPSSSSCTNNI*GSCLLDRWGK*SSL WCQ*IHWIRASHSSQQPE*CPRHHCLS*TCTAI R*KLV*RRHGEWRM*IPMPASTTD**SLSKIYLF LSQWVQCRGKWPRLSKYCNYCDLQ*DKRYEHNR NFSN*WTSSWRDQCDHSSIRGQCSPKRDFCRMG HSSSLALSDGSSRWLLDVAELATQEHEKHEL*QS CVLENH*RGPLHRHW*TQCFCWTHVPSNISCKH R**SSLTSVTNVDL*GLNK*YPRRNGNRASS*S LFFFLSAGRTSRYLCVDQACVLDRFYITFVNILV HILLQLWMWLPSICNP*ISRQYCHLWPNMHFP* KAIFQQ*NLCYSVYHLYIHCIGHL*ISQRTITI LKHFENISM*IIVNFFNGWDNGNRTKRVTKMKLP KKFIN*FCTYE*YL*PQWRFAKTECSNYCTFFF KC*KIKPSSLTM

Frame 1

SPAAAGAGAPLPAPLRSVLSSALGSPPPLPSLL SPCLPSSAAPALFSARRLGLHCCCSPGRWLGGW GGDCASCRGGGALFFPAPFPRQLLPLLLPLSPPR PHLLPPFGRTGNLSCGANGGGGGGGGTIQAGTM GTSALWALWLLLALCWAPRESGATGTGRKAKCE PSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV KKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGS DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC DGENDCDSGEDEENCGNITCSPDEFTCSSGRCIS RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS TSSCIPISWVCDDDADCSDQSDESLEQCGRQPV IHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIR DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS HICKDLVIGYECDCAAGFELIDRKTCGDIDECQ NPGICSQICINLKGGYKCECSRGYQMDLATGVC KAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL RNTVALDADIAAQKLFWADLSQKAIFSASIDDK VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS KTISVATLDGTKRKFLFNSDLREPASIAVDPLSG FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQW PNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR RIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVY GANKFTGSELATLVNNLNDAQDIIVYHELVQPS GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTC SCPSGYNVEENGRDCQSTATTVTYSETKDTNTTE ISATSGLVPGGINVTTAVSEVSVPPKGTSAAWA ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDN PVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST DDDLA*LL*QMLTFEV*TNNTPVGMVTEPAAEV SFSSSRLEEHQDTFAWIKLVYLTVFILLL*IFL STFYFSFGCGYRVSVTLEFLDSIATSGQICTFPR KPYSSSETCAIVYTTCTYIV*AICKYPREQSLF LSTLKIFLCKLL*TFSMVGTMAIGQNGLLR*NC QKNL*TNFVRMNDIFDLNGGLQRLSVQTTVHFFS SAKKLNQAA*P

Frame 2

LRPPPVRVLRYRLLSVLCSLLLSAPHPLSLPSS PLASPPLQRLHYFLPAGSACTAAAARGGGWVGG EETVQVVGEGVPSSSPLPSPANSFPSFSPFPLP APTFFLLSEGLVTCRAERTAAAAAAAAPSRRAPW ARPRSGRSGCCSRCAGRPGRAAPPEPGEKPNVN PPNSSAQMVAVLRCCGNVMGMKTVLTAVMKRTV *RRRVLNLTSCATMASVFPADGSVMEILTAKMVQ MKAQNSAI*EHAAYMKSAVAPILLSVSQCPGDV MVKMIVTVEKMKKTVAI*HVVPTSSPAPVAAAS PGTLYAMARMTAAMAVMSWTVPRQPVAPMSSSAA PPPASPSAGYATMMQTAPTNLMSPWSSVAVSQS YTPSVQPAKSSAALASASIRSGDVMGTLTARMA VMRSTVPLELADLTNLNVRMAAASMAAGSVMVSE TVSMVPMKSTAKMSISAWALENSSAEVENA*IS AKYVTRSRTAGTGVMSP*KSVI*TNAW*IMVDV LISAKT*L*ATSVTVQLGLN**IGKPVEILMNAK IQESAVKFVST*KAVTSVNVVVAIKWILLLACA RQ*AKSQV*SSLIEETSGRLA*RGKNISN*LNS *ETLWLSMLTLLPRNYSGPI*AKRLSSVPQLMTR LVDMLK*STMSIILQPLLLIGCTRPSTGLMRLL RLFQ*LP*MEPRGSSCLTLTCESLPP*LWTHCL ALFTGQTGVNQLK*KKQE*MDSIDVHW*QRISSG LTELHLTL*KVASIGLILSCTCYPAWT*MAKIV G*Y*SLWSS*LILLH*QYLRIVSTG*MGKMKQS MVPINSLDQS*PL*STT*MMPKTSLSIMNLYSHQ VKIGVKKTWRMEDVNTYACQHHRLMITLQNIPV PVPVGTM*RKMAETVKVLQLL*LTVRQKIRTQQ KFQQLVD*FLEGSM*PQQYQRSVFPQKGLLPHGP FFLSCS**WQQ*VAT*CGGIGNTRT*KA*TLTI LCT*KPLKRTSP*TLVDTVLLLDTRTQQYQL*A QMMI*LDFCDKC*PLRSKQIIPPSEW*PSQQLKS LFLPLGWKNIKIPLRGSSLCT*PFLYYFCKYSC PHSTSALDVVTEYL*PLNF*TVLPPLAKYALSL ESHIPAVKLVL*CIPPVHTLYRPSVNIPENNHYS *AL*KYFYVNYCKLFQWLGQWQ*DKTGY*DEIA KKIYKLILYV*MISLTSMEVCKD*VFKLLYIFF QVLKN*TKQLNH