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Sequences

Sequence NM_199443

ATAGCACGCCGCGCGCGGGGCGGATGTCCGGGCCGGCTGGGCCGGGGCCGCGGAGGAGATGGCGGAAGGTGGAGGCTGCCGTGAGCGACCGGATGCGGAG ACTCAGAAGTCCGAGCTTGGACCCTTAATGAGGACCACACTCCAACGCGGGGCGCAGTGGTATCTTATTGACAGCCGGTGGTTCAAGCAGTGGAAGAAGT ATGTGGGCTTTGACAGCTGGGACATGTACAATGTGGGTGAACATAACCTATTTCCTGGCCCAATAGACAACTCTGGGCTATTTTCAGATCCTGAGAGTCA GACCTTGAAAGAACACTTAATTGATGAATTGGACTATGTATTGGTCCCTACCGAGGCGTGGAATAAACTACTAAACTGGTACGGCTGTGTAGAAGGCCAG CAACCCATCGTCAGAAAAGTTGTGGAGCATGGCCTGTTTGTCAAGCACTGCAAAGTCGAGGTGTATTTGCTGGAACTGAAGCTCTGTGAGAACAGTGACC CCACCAATGTGCTGAGTTGCCATTTCAGCAAGGCAGACACCATTGCAACCATCGAGAAAGAGATGCGGAAGCTATTCAACATCCCTGCGGAGCGTGAAAC ACGGCTCTGGAACAAATACATGAGCAACACCTACGAGCAGTTGAGCAAGCTAGACAACACTGTCCAGGATGCTGGGCTATACCAGGGTCAGGTGCTAGTA ATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTTGCAGTCAAATGGATCTGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCT CTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAACTCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGA CTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAG ATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACGTTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTC AGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAAAAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGA TGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTGTGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGC CCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACTGCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTC CTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCTGTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCAT TGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCCAAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGAC ATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCCAGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTT CCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTAACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAG CCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGGCCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAG GAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGGGGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAA AGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCCTATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAA ACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGAGACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAG CATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTGCATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATG ACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTATGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTT CTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAGGGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGG CCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCACTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGT ATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCAGCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTA TAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCTCTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGAC ACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGGAGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCT AAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAAGAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAGGCTGAA TTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAGGGGGTGGGATGGGGGTACTCAATGGAGTATGTCTGATGGAT CCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCACCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTGAT GCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACCCAAACCTCAAGTAAACTCCCCTTTCCCTCGCTATGTGCACTGATATGGGTTTATAATTTT CTGAAAGTTACCCACTGAAGCCCATTTCTCCGTTGAGTCATCTTGTAATTTCCAGCTTTCTCCCCGCTAAGGAAGATATCTAGTGTTGGGGATCCTGGCC CCTCAACCTCCTGTGGAACCCAGCAGTTCTGTTATATCCCCTGCTACCCTAGATGAATTAAGACGGTTAAATACTGTGTGGAACTTTTATTAGATAACAC ACTTTTTATTAGATAACGCTTAAAGGAAGTCAGTACATAAAA

refseq_USP4.F1 (forward primer)
refseq_USP4.R1 (reverse primer)
Single exon skipping

Frame 0

IARRARGGCPGRLGRGRGGDGGRWRLP*ATGCG DSEVRAWTLNEDHTPTRGAVVSY*QPVVQAVEEV CGL*QLGHVQCG*T*PISWPNRQLWAIFRS*ES DLERTLN**IGLCIGPYRGVE*TTKLVRLCRRP ATHRQKSCGAWPVCQALQSRGVFAGTEAL*EQ*P HQCAELPFQQGRHHCNHRERDAEAIQHPCGA*N TALEQIHEQHLRAVEQARQHCPGCWAIPGSGAS N*ASK*RWHMAQADLAVKWIWLFCFV*LSGATIL SYTTWALWTWKPGKHLLHELRFAVFEQHCTTD* LLSQR*V*SRNQQRQPSGDERGNCRSLC*TH*A DVVWKGRPCGTSHVQNSSRTFCSSIFWLPATRFS GAAGLSSRWIA*RSEPGKEKALLGAEGCQWAAR CGGGKGSLGESQVEE*FCDCGYFPWPLQIYFGL PRMC*GFCDL*PILLSNAATALEERSSYGGFPGS C*PSLQTYSVPCDCAADGGCVRPVRGSLQAVWH CCRKYGGRRCV*SPIPQNFPNG*RFKPHHASG* HFRVRGLQHFRGWLGMCHASSLLQGEEVQAIKHF LRISAIWAATIAFCPQAQVNP*VFVPGCL*SYQ PLCETAFT**VWQLTLGARGLQWLQEQL*RRR* GRNGASGRRQRAAFRNRRQWGR*ARK*PQ*DHPK EDQRPALPKKAFYLQSCELLWNS*HKFTCS*WK TT*TQLSIYTGHGLGQ*NSETLL**ARI*GLRE ACEHVAASEEEEDHSGPERLHRALHHHGDPWGA* PLVLSQL*EASTGHKKV*PMVLAQDPGGPPQTF LLQQILEG*ARHSRRIPNQRAEHVRVCL*PVSK ALCVRPHCRVQSLWSHGGWPLHCICEEQTEW*MV LL***QRVPGL*GSDSD*SSLCAILPTSR**IL *DTFT*QFWFL*WRDTTKQLSAGLWG**GLQHG HQLMLTPRSCHPVAPV*SPRRTSLTLCRLLVFCL KTRQGNTLLL*AEGNKKKKRRPFT*KKLCQEAE LFLFLNRW*EISVKPVKLKRGWDGGTQWSMSDG SRRMERNTGAEYGAAWRPTPPAGLP*APGFLVLM PILVTPSSLLTVTQTSSKLPFPSLCALIWVYNF LKVTH*SPFLR*VIL*FPAFSPLRKISSVGDPG PSTSCGTQQFCYIPCYPR*IKTVKYCVELLLDNT LFIR*RLKEVST*

Frame 1

*HAARGADVRAGWAGAAEEMAEGGGCRERPDAE TQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKK YVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQ TLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQ QPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD PTNVLSCHFSKADTIATIEKEMRKLFNIPAERET RLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLV IEPQNEDGTWPRQTLQSNGSGFSASYNCQEPPS SHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTD YFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQ MWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDS QELLAFLLDGLHEDLNRVKKKPYLELKDANGRPD AVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVC PECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLV PADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGI AAENMVVADVYNHRFHKIFQMDEGLNHIMPRDD IFVYEVCSTSVDGSECVTLPVYFRERKSRPSST SSASALYGQPLLLSVPKHKLTLESLYQAVCDRIS RYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDE EEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQ KKIKGQPCPKRLFTFSLVNSYGTADINSLAADGK LLKLNSRSTLAMDWDSETRRLYYDEQESEAYEK HVSMLQPQKKKKTTVALRDCIELFTTMETLGEH DPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRF SYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSAR PYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKW YYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFY KTPSLSSSGSSDGGTRPSSSQQGFGDDEACSMD TN*C*LHDPATL*RQCNPPGEHL*HSADC*CSV *KPDKEIPFFYEQKETKKKKEDRLPRRSYVKRLN YFYF*TGGEKFL*NL*S*KGGGMGVLNGVCLMD PEEWRGTQALSMEQPGDPPHLQGCPERLDFWF* CQY*SPQVVCSQ*PKPQVNSPFPRYVH*YGFIIF *KLPTEAHFSVESSCNFQLSPR*GRYLVLGILA PQPPVEPSSSVISPATLDELRRLNTVWNFY*IT HFLLDNA*RKSVHK

Frame 2

STPRAGRMSGPAGPGPRRRWRKVEAAVSDRMRR LRSPSLDP**GPHSNAGRSGILLTAGGSSSGRS MWALTAGTCTMWVNITYFLAQ*TTLGYFQILRV RP*KNT*LMNWTMYWSLPRRGINY*TGTAV*KAS NPSSEKLWSMACLSSTAKSRCICWN*SSVRTVT PPMC*VAISARQTPLQPSRKRCGSYSTSLRSVK HGSGTNT*ATPTSS*AS*TTLSRMLGYTRVRC** LSLKMKMAHGPGRPCSQMDLAFLLRIIVRSHHP LIYNLGSVDLETWETPAS*TPLCSV*ATLHH*L TTFSKMSMKPKSTETTLWG*KGKLQKPMLNSLSR CGLEGTPMWHLACSKLK*DVLLLNFLATSNKIL RSCWPFF*MDCMKI*TG*RKSPTWS*RMPMGGQ MRWWQRKPGRITG*GMIL*LWILSMASSNLLWFA QNVLRFL*PLTHFAI*RCHCP*RKIELWRFSWF LLTLTADLLSTV*LCR*WGLCPTCARLSPGCLA LLQKIWWSQMCIITDSTKFSKWMKV*TTSCLGMT FSCTRSAALPWMARNVSRFQSTSGRGSPGHQAL PPHQRYMGSHYCFLSPSTS*PLSLCTRLFVIVS AAM*NSLYLMSLAAHPWSQGPAMAPGTAVKEKMR KKWSIRKKAKSSFQKQKAVGKMSQEMTPVRPPK RRSKASPAQKGFLPSVL*TPMEQLT*IHLQLME NYLNSTLDLHWPWIGTVKLGDFTMMSKNLRPTRS M*ACCSLRRRRRPQWP*ETASSSSPPWRPLGSM TPGTVPTVRSINRPQKSLTYGPCPRSWWSTSNV SPTTDTGGISSTQS*NSQSEG*TCPSLSVTCQQG LMCTTSLPCPIIMEPWGLATTLHMRRTN*MVNG ITLMIATCPWPLRIR**LKQLMCYFTNVEMMNF IRHLHLAVLVPLMEGHDQAALSRALGMMRLAAWT PTNADSTILPPCSASVIPQENIFDTLQTASVLS KNQTRKYPSFMSRRKQKKKKKTVYLEEAMSRG* IIFIFKQVVRNFCETCEAEKGVGWGYSMEYV*WI PKNGEEHRR*VWSSLETHPTCRAALSAWISGSD ANTSHPK*SAHSNPNLK*TPLSLAMCTDMGL*F SESYPLKPISPLSHLVISSFLPAKEDI*CWGSWP LNLLWNPAVLLYPLLP*MN*DG*ILCGTFIR*H TFY*ITLKGSQYIK

Sequence NM_003363

ATAGCACGCCGCGCGCGGGGCGGATGTCCGGGCCGGCTGGGCCGGGGCCGCGGAGGAGATGGCGGAAGGTGGAGGCTGCCGTGAGCGACCGGATGCGGAG ACTCAGAAGTCCGAGCTTGGACCCTTAATGAGGACCACACTCCAACGCGGGGCGCAGTGGTATCTTATTGACAGCCGGTGGTTCAAGCAGTGGAAGAAGT ATGTGGGCTTTGACAGCTGGGACATGTACAATGTGGGTGAACATAACCTATTTCCTGGCCCAATAGACAACTCTGGGCTATTTTCAGATCCTGAGAGTCA GACCTTGAAAGAACACTTAATTGATGAATTGGACTATGTATTGGTCCCTACCGAGGCGTGGAATAAACTACTAAACTGGTACGGCTGTGTAGAAGGCCAG CAACCCATCGTCAGAAAAGTTGTGGAGCATGGCCTGTTTGTCAAGCACTGCAAAGTCGAGGTGTATTTGCTGGAACTGAAGCTCTGTGAGAACAGTGACC CCACCAATGTGCTGAGTTGCCATTTCAGCAAGGCAGACACCATTGCAACCATCGAGAAAGAGATGCGGAAGCTATTCAACATCCCTGCGGAGCGTGAAAC ACGGCTCTGGAACAAATACATGAGCAACACCTACGAGCAGTTGAGCAAGCTAGACAACACTGTCCAGGATGCTGGGCTATACCAGGGTCAGGTGCTAGTA ATTGAGCCTCAAAATGAAGATGGCACATGGCCCAGGCAGACCTTGCAGTCAAAATCAAGCACTGCGCCTAGCAGAAATTTTACTACCTCTCCAAAATCAT CAGCAAGTCCCTATTCCTCAGTGTCTGCCTCTCTCATTGCAAATGGTGATAGCACTAGCACCTGTGGGATGCACAGTTCCGGTGTCAGCAGGGGTGGATC TGGCTTTTCTGCTTCGTATAATTGTCAGGAGCCACCATCCTCTCATATACAACCTGGGCTCTGTGGACTTGGAAACCTGGGAAACACCTGCTTCATGAAC TCCGCTTTGCAGTGTTTGAGCAACACTGCACCACTGACTGACTACTTTCTCAAAGATGAGTATGAAGCCGAAATCAACAGAGACAACCCTCTGGGGATGA AAGGGGAAATTGCAGAAGCCTATGCTGAACTCATTAAGCAGATGTGGTCTGGAAGGGACGCCCATGTGGCACCTCGCATGTTCAAAACTCAAGTAGGACG TTTTGCTCCTCAATTTTCTGGCTACCAGCAACAAGATTCTCAGGAGCTGCTGGCCTTTCTTCTAGATGGATTGCATGAAGATCTGAACCGGGTAAAGAAA AAGCCCTACTTGGAGCTGAAGGATGCCAATGGGCGGCCAGATGCGGTGGTGGCAAAGGAAGCCTGGGAGAATCACAGGTTGAGGAATGATTCTGTGATTG TGGATACTTTCCATGGCCTCTTCAAATCTACTTTGGTTTGCCCAGAATGTGCTAAGGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACGCTGCCACT GCCCTTGAAGAAAGATCGAGTTATGGAGGTTTTCCTGGTTCCTGCTGACCCTCACTGCAGACCTACTCAGTACCGTGTGACTGTGCCGCTGATGGGGGCT GTGTCCGACCTGTGCGAGGCTCTCTCCAGGCTGTCTGGCATTGCTGCAGAAAATATGGTGGTCGCAGATGTGTATAATCACCGATTCCACAAAATTTTCC AAATGGATGAAGGTTTAAACCACATCATGCCTCGGGATGACATTTTCGTGTACGAGGTCTGCAGCACTTCCGTGGATGGCTCGGAATGTGTCACGCTTCC AGTCTACTTCAGGGAGAGGAAGTCCAGGCCATCAAGCACTTCCTCCGCATCAGCGCTATATGGGCAGCCACTATTGCTTTCTGTCCCCAAGCACAAGTTA ACCCTTGAGTCTTTGTACCAGGCTGTTTGTGATCGTATCAGCCGCTATGTGAAACAGCCTTTACCTGATGAGTTTGGCAGCTCACCCTTGGAGCCAGGGG CCTGCAATGGCTCCAGGAACAGCTGTGAAGGAGAAGATGAGGAAGAAATGGAGCATCAGGAAGAAGGCAAAGAGCAGCTTTCAGAAACAGAAGGCAGTGG GGAAGATGAGCCAGGAAATGACCCCAGTGAGACCACCCAAAAGAAGATCAAAGGCCAGCCCTGCCCAAAAAGGCTTTTTACCTTCAGTCTTGTGAACTCC TATGGAACAGCTGACATAAATTCACTTGCAGCTGATGGAAAACTACTTAAACTCAACTCTCGATCTACACTGGCCATGGATTGGGACAGTGAAACTCGGA GACTTTACTATGATGAGCAAGAATCTGAGGCCTACGAGAAGCATGTGAGCATGTTGCAGCCTCAGAAGAAGAAGAAGACCACAGTGGCCCTGAGAGACTG CATCGAGCTCTTCACCACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCAACTGTAAGAAGCATCAACAGGCCACAAAAAAGTTTGACCTA TGGTCCTTGCCCAAGATCCTGGTGGTCCACCTCAAACGTTTCTCCTACAACAGATACTGGAGGGATAAGCTCGACACAGTCGTAGAATTCCCAATCAGAG GGCTGAACATGTCCGAGTTTGTCTGTAACCTGTCAGCAAGGCCTTATGTGTACGACCTCATTGCCGTGTCCAATCATTATGGAGCCATGGGGGTTGGCCA CTACACTGCATATGCGAAGAACAAACTGAATGGTAAATGGTATTACTTTGATGATAGCAACGTGTCCCTGGCCTCTGAGGATCAGATAGTGACTAAAGCA GCTTATGTGCTATTTTACCAACGTCGAGATGATGAATTTTATAAGACACCTTCACTTAGCAGTTCTGGTTCCTCTGATGGAGGGACACGACCAAGCAGCT CTCAGCAGGGCTTTGGGGATGATGAGGCTTGCAGCATGGACACCAACTAATGCTGACTCCACGATCCTGCCACCCTGTAGCGCCAGTGTAATCCCCCAGG AGAACATCTTTGACACTCTGCAGACTGCTAGTGTTCTGTCTAAAAACCAGACAAGGAAATACCCTTCTTTTATGAGCAGAAGGAAACAAAAAAAAAAAAA GAAGACCGTTTACCTAGAAGAAGCTATGTCAAGAGGCTGAATTATTTTTATTTTTAAACAGGTGGTGAGAAATTTCTGTGAAACCTGTGAAGCTGAAAAG GGGGTGGGATGGGGGTACTCAATGGAGTATGTCTGATGGATCCCGAAGAATGGAGAGGAACACAGGCGCTGAGTATGGAGCAGCCTGGAGACCCACCCCA CCTGCAGGGCTGCCCTGAGCGCCTGGATTTCTGGTTCTGATGCCAATACTAGTCACCCCAAGTAGTCTGCTCACAGTAACCCAAACCTCAAGTAAACTCC CCTTTCCCTCGCTATGTGCACTGATATGGGTTTATAATTTTCTGAAAGTTACCCACTGAAGCCCATTTCTCCGTTGAGTCATCTTGTAATTTCCAGCTTT CTCCCCGCTAAGGAAGATATCTAGTGTTGGGGATCCTGGCCCCTCAACCTCCTGTGGAACCCAGCAGTTCTGTTATATCCCCTGCTACCCTAGATGAATT AAGACGGTTAAATACTGTGTGGAACTTTTATTAGATAACACACTTTTTATTAGATAACGCTTAAAGGAAGTCAGTACATAAAA

refseq_USP4.F1 (forward primer)
refseq_USP4.R1 (reverse primer)
Single exon skipping

Frame 0

IARRARGGCPGRLGRGRGGDGGRWRLP*ATGCG DSEVRAWTLNEDHTPTRGAVVSY*QPVVQAVEEV CGL*QLGHVQCG*T*PISWPNRQLWAIFRS*ES DLERTLN**IGLCIGPYRGVE*TTKLVRLCRRP ATHRQKSCGAWPVCQALQSRGVFAGTEAL*EQ*P HQCAELPFQQGRHHCNHRERDAEAIQHPCGA*N TALEQIHEQHLRAVEQARQHCPGCWAIPGSGAS N*ASK*RWHMAQADLAVKIKHCA*QKFYYLSKII SKSLFLSVCLSHCKW**H*HLWDAQFRCQQGWI WLFCFV*LSGATILSYTTWALWTWKPGKHLLHE LRFAVFEQHCTTD*LLSQR*V*SRNQQRQPSGDE RGNCRSLC*TH*ADVVWKGRPCGTSHVQNSSRT FCSSIFWLPATRFSGAAGLSSRWIA*RSEPGKE KALLGAEGCQWAARCGGGKGSLGESQVEE*FCDC GYFPWPLQIYFGLPRMC*GFCDL*PILLSNAAT ALEERSSYGGFPGSC*PSLQTYSVPCDCAADGG CVRPVRGSLQAVWHCCRKYGGRRCV*SPIPQNFP NG*RFKPHHASG*HFRVRGLQHFRGWLGMCHAS SLLQGEEVQAIKHFLRISAIWAATIAFCPQAQV NP*VFVPGCL*SYQPLCETAFT**VWQLTLGARG LQWLQEQL*RRR*GRNGASGRRQRAAFRNRRQW GR*ARK*PQ*DHPKEDQRPALPKKAFYLQSCEL LWNS*HKFTCS*WKTT*TQLSIYTGHGLGQ*NSE TLL**ARI*GLREACEHVAASEEEEDHSGPERL HRALHHHGDPWGA*PLVLSQL*EASTGHKKV*P MVLAQDPGGPPQTFLLQQILEG*ARHSRRIPNQR AEHVRVCL*PVSKALCVRPHCRVQSLWSHGGWP LHCICEEQTEW*MVLL***QRVPGL*GSDSD*S SLCAILPTSR**IL*DTFT*QFWFL*WRDTTKQL SAGLWG**GLQHGHQLMLTPRSCHPVAPV*SPR RTSLTLCRLLVFCLKTRQGNTLLL*AEGNKKKK RRPFT*KKLCQEAELFLFLNRW*EISVKPVKLKR GWDGGTQWSMSDGSRRMERNTGAEYGAAWRPTP PAGLP*APGFLVLMPILVTPSSLLTVTQTSSKL PFPSLCALIWVYNFLKVTH*SPFLR*VIL*FPAF SPLRKISSVGDPGPSTSCGTQQFCYIPCYPR*I KTVKYCVELLLDNTLFIR*RLKEVST*

Frame 1

*HAARGADVRAGWAGAAEEMAEGGGCRERPDAE TQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKK YVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQ TLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQ QPIVRKVVEHGLFVKHCKVEVYLLELKLCENSD PTNVLSCHFSKADTIATIEKEMRKLFNIPAERET RLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLV IEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKS SASPYSSVSASLIANGDSTSTCGMHSSGVSRGGS GFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMN SALQCLSNTAPLTDYFLKDEYEAEINRDNPLGM KGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGR FAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKK KPYLELKDANGRPDAVVAKEAWENHRLRNDSVI VDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPL PLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGA VSDLCEALSRLSGIAAENMVVADVYNHRFHKIF QMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLP VYFRERKSRPSSTSSASALYGQPLLLSVPKHKL TLESLYQAVCDRISRYVKQPLPDEFGSSPLEPG ACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSG EDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNS YGTADINSLAADGKLLKLNSRSTLAMDWDSETR RLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDC IELFTTMETLGEHDPWYCPNCKKHQQATKKFDL WSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIR GLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGH YTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKA AYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSS SQQGFGDDEACSMDTN*C*LHDPATL*RQCNPPG EHL*HSADC*CSV*KPDKEIPFFYEQKETKKKK EDRLPRRSYVKRLNYFYF*TGGEKFL*NL*S*K GGGMGVLNGVCLMDPEEWRGTQALSMEQPGDPPH LQGCPERLDFWF*CQY*SPQVVCSQ*PKPQVNS PFPRYVH*YGFIIF*KLPTEAHFSVESSCNFQL SPR*GRYLVLGILAPQPPVEPSSSVISPATLDEL RRLNTVWNFY*ITHFLLDNA*RKSVHK

Frame 2

STPRAGRMSGPAGPGPRRRWRKVEAAVSDRMRR LRSPSLDP**GPHSNAGRSGILLTAGGSSSGRS MWALTAGTCTMWVNITYFLAQ*TTLGYFQILRV RP*KNT*LMNWTMYWSLPRRGINY*TGTAV*KAS NPSSEKLWSMACLSSTAKSRCICWN*SSVRTVT PPMC*VAISARQTPLQPSRKRCGSYSTSLRSVK HGSGTNT*ATPTSS*AS*TTLSRMLGYTRVRC** LSLKMKMAHGPGRPCSQNQALRLAEILLPLQNH QQVPIPQCLPLSLQMVIALAPVGCTVPVSAGVD LAFLLRIIVRSHHPLIYNLGSVDLETWETPAS*T PLCSV*ATLHH*LTTFSKMSMKPKSTETTLWG* KGKLQKPMLNSLSRCGLEGTPMWHLACSKLK*D VLLLNFLATSNKILRSCWPFF*MDCMKI*TG*RK SPTWS*RMPMGGQMRWWQRKPGRITG*GMIL*L WILSMASSNLLWFAQNVLRFL*PLTHFAI*RCH CP*RKIELWRFSWFLLTLTADLLSTV*LCR*WGL CPTCARLSPGCLALLQKIWWSQMCIITDSTKFS KWMKV*TTSCLGMTFSCTRSAALPWMARNVSRF QSTSGRGSPGHQALPPHQRYMGSHYCFLSPSTS* PLSLCTRLFVIVSAAM*NSLYLMSLAAHPWSQG PAMAPGTAVKEKMRKKWSIRKKAKSSFQKQKAV GKMSQEMTPVRPPKRRSKASPAQKGFLPSVL*TP MEQLT*IHLQLMENYLNSTLDLHWPWIGTVKLG DFTMMSKNLRPTRSM*ACCSLRRRRRPQWP*ET ASSSSPPWRPLGSMTPGTVPTVRSINRPQKSLTY GPCPRSWWSTSNVSPTTDTGGISSTQS*NSQSE G*TCPSLSVTCQQGLMCTTSLPCPIIMEPWGLA TTLHMRRTN*MVNGITLMIATCPWPLRIR**LKQ LMCYFTNVEMMNFIRHLHLAVLVPLMEGHDQAA LSRALGMMRLAAWTPTNADSTILPPCSASVIPQ ENIFDTLQTASVLSKNQTRKYPSFMSRRKQKKKK KTVYLEEAMSRG*IIFIFKQVVRNFCETCEAEK GVGWGYSMEYV*WIPKNGEEHRR*VWSSLETHP TCRAALSAWISGSDANTSHPK*SAHSNPNLK*TP LSLAMCTDMGL*FSESYPLKPISPLSHLVISSF LPAKEDI*CWGSWPLNLLWNPAVLLYPLLP*MN *DG*ILCGTFIR*HTFY*ITLKGSQYIK