Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence NM_003895

GAGGAGGAGCCGGAGGAAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGC CTCATAGTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTCATCTGCAGAAAAAGAGGCAATCAAGGGTACAT ACTCCAAAGTACTGGATGCATATGGACTCTTAGGTGTTCTGCGGTTAAATCTTGGTGATACTATGTTACATTATCTGGTCCTAGTCACTGGATGTATGTC TGTTGGAAAAATTCAAGAATCTGAAGTTTTCCGAGTTACTTCCACTGAGTTTATATCACTGCGAATCGATTCTTCAGATGAGGATCGCATTTCAGAAGTG CGGAAAGTTTTGAATTCAGGAAACTTTTATTTTGCATGGTCTGCATCTGGCATCAGTTTAGATTTGAGTCTTAATGCGCATCGTAGCATGCAAGAACAGA CAACTGATAATAGATTTTTCTGGAATCAGTCTTTGCATTTGCATCTCAAACACTATGGCGTGAATTGTGATGACTGGTTATTACGTCTTATGTGTGGAGG AGTAGAAATCAGAACAATTTATGCTGCTCATAAACAGGCGAAGGCTTGCCTCATTTCAAGATTAAGCTGTGAACGAGCTGGGACCAGGTTTAATGTCCGG GGAACAAATGATGATGGTCATGTTGCCAATTTTGTAGAAACAGAACAGGTTGTGTACTTAGATGACTCAGTTTCTTCCTTCATACAAATCCGAGGATCTG TTCCATTGTTCTGGGAGCAACCAGGGTTGCAAGTGGGATCTCATCGTGTCCGTATGTCAAGGGGATTTGAAGCCAATGCACCTGCTTTTGACAGGCATTT TAGAACACTTAAGAACTTATATGGTAAACAAATAATAGTAAATTTGCTTGGATCTAAGGAAGGTGAACATATGCTAAGTAAAGCTTTCCAGAGTCATTTG AAAGCTTCTGAACATGCTGCTGATATCCAGATGGTGAATTTTGACTATCATCAAATGGTTAAGGGAGGAAAGGCAGAAAAATTACATAGTGTTCTTAAAC CTCAAGTCCAGAAGTTTCTAGATTATGGATTTTTTTATTTCAATGGAAGTGAAGTTCAAAGATGCCAGAGTGGTACAGTTCGAACAAACTGCTTGGATTG TCTTGATAGAACAAATAGTGTGCAGGCATTTCTTGGCTTAGAGATGCTAGCTAAACAGTTGGAAGCTCTTGGTTTAGCTGAAAAGCCTCAGTTGGTGACT CGCTTTCAAGAAGTTTTTCGGTCAATGTGGTCCGTGAATGGTGATTCAATCAGTAAGATATATGCAGGAACTGGAGCTCTTGAAGGGAAAGCGAAGTTAA AAGATGGTGCTCGCTCTGTTACCCGAACAATTCAGAATAACTTCTTTGACAGCTCCAAGCAAGAGGCCATTGATGTTTTGCTACTGGGAAATACTCTGAA TAGTGATTTAGCTGACAAAGCTCGAGCACTTTTAACTACTGGAAGTTTGCGTGTTTCTGAGCAGACATTACAGTCAGCATCTTCTAAAGTACTAAAGAGC ATGTGTGAGAATTTCTACAAATATTCAAAGCCTAAGAAAATTCGAGTATGTGTCGGAACCTGGAATGTGAATGGTGGGAAGCAATTTCGCAGCATAGCTT TTAAGAATCAGACACTCACTGACTGGCTTCTTGATGCACCCAAGTTAGCTGGCATCCAGGAGTTTCAAGATAAAAGAAGTAAGCCAACTGATATATTTGC AATTGGTTTTGAAGAAATGGTAGAATTGAATGCTGGAAACATTGTGAGTGCAAGCACAACAAATCAGAAGCTCTGGGCTGTAGAACTTCAGAAGACAATC TCCAGAGACAACAAGTATGTGCTGCTGGCTTCTGAACAGTTGGTGGGCGTCTGTTTGTTTGTTTTTATCAGACCACAGCATGCTCCTTTTATCAGGGATG TTGCAGTTGATACTGTGAAGACTGGAATGGGAGGTGCAACTGGAAATAAGGGAGCAGTTGCAATCCGAATGCTCTTCCATACAACCAGCCTTTGCTTCGT CTGTAGCCACTTTGCTGCAGGGCAGTCACAAGTCAAAGAAAGAAATGAAGATTTTATAGAAATAGCACGAAAATTGAGTTTTCCTATGGGAAGGATGCTA TTTTCCCATGACTATGTATTTTGGTGTGGTGATTTCAACTATCGAATCGATCTCCCTAACGAAGAAGTTAAAGAGCTCATAAGACAGCAAAATTGGGATT CTCTTATAGCAGGAGATCAACTTATCAATCAGAAAAATGCTGGACAGGTTTTTAGAGGATTTTTAGAAGGAAAGGTAACCTTTGCTCCGACATATAAGTA TGACTTGTTTTCTGACGACTATGACACCAGTGAAAAGTGCCGCACCCCTGCCTGGACAGACCGTGTCCTTTGGAGAAGGAGGAAATGGCCTTTTGATAGA TCAGCTGAAGATCTAGATCTTCTAAATGCTAGTTTTCAAGATGAAAGCAAAATTCTGTACACGTGGACTCCAGGCACTTTGCTGCACTATGGAAGAGCTG AGCTGAAGACTTCTGACCACAGGCCTGTCGTTGCCCTGATTGATATAGATATATTTGAAGTTGAAGCTGAAGAGAGGCAAAACATTTATAAAGAAGTAAT TGCAGTTCAGGGTCCACCAGATGGTACAGTATTGGTCTCAATCAAAAGTTCTTTACCAGAAAATAATTTTTTTGATGATGCCTTGATTGATGAGCTTCTG CAGCAGTTTGCAAGTTTTGGTGAAGTTATACTTATAAGATTTGTAGAAGATAAAATGTGGGTTACATTTTTGGAGGGAAGCTCTGCCTTGAATGTTCTGA GCCTAAATGGTAAAGAGTTATTGAATCGGACTATAACTATTGCTTTAAAAAGTCCAGACTGGATCAAAAATTTGGAAGAAGAAATGAGTTTAGAGAAAAT TAGCATTGCATTGCCATCATCAACAAGCTCTACCCTGCTTGGTGAAGATGCAGAGGTTGCAGCAGATTTTGATATGGAAGGTGATGTTGATGACTATAGT GCTGAAGTGGAGGAACTTCTTCCTCAGCATCTCCAGCCATCTTCAAGTTCCGGCCTTGGTACTTCCCCCAGCTCTTCACCCCGAACTAGTCCCTGCCAGT CACCTACAATATCAGAGGGTCCTGTACCTTCCCTTCCCATCAGACCAAGCCGAGCACCGTCAAGAACTCCTGGGCCTCCCAGTGCACAGAGTTCTCCTAT TGACGCGCAGCCAGCAACGCCGCTGCCGCAGAAAGACCCCGCCCAGCCCTTGGAGCCCAAGCGGCCGCCGCCGCCCCGCCCGGTCGCCCCTCCCACACGC CCGGCTCCCCCACAGAGACCTCCTCCGCCTTCAGGGGCTAGGAGTCCTGCACCCACTAGAAAGGAATTTGGAGGTATTGGAGCCCCTCCCAGTCCTGGGG TAGCTAGGAGAGAGATGGAAGCACCCAAAAGCCCTGGAACAACAAGGAAAGATAATATAGGACGCAGTCAGCCTTCACCTCAAGCAGGACTTGCAGGCCC AGGACCTGCTGGATACAGTACAGCCAGACCGACGATTCCTCCTCGTGCTGGAGTTATCAGTGCCCCACAGAGCCACGCGCGGGCATCTGCTGGAAGACTG ACTCCTGAAAGCCAAAGCAAAACATCAGAAACGTCGAAAGGTTCAACTTTCCTTCCTGAACCACTGAAGCCTCAGGCTGCTTTTCCTCCGCAGTCTTCTT TGCCCCCGCCTGCTCAAAGGTTGCAAGAGCCTCTTGTCCCTGTGGCAGCACCTATGCCTCAGTCTGGCCCCCAGCCAAATTTGGAAACCCCACCACAACC ACCACCTCGAAGCAGGTCATCCCATAGCTTGCCTTCAGAAGCTTCCTCACAACCGCAAGTAAAAACAAATGGAATCTCTGATGGCAAAAGAGAATCACCA TTAAAGATTGACCCATTTGAAGATCTGTCATTTAATCTGCTTGCTGTATCAAAGGCTCAGCTATCTGTTCAAACGTCACCTGTTCCCACCCCAGACCCAA AGAGGTTGATTCAGTTGCCTTCTGCAACGCAAAGTAATGTTTTGAGTTCTGTAAGTTGCATGCCAACAATGCCTCCAATTCCAGCTCGGAGTCAATCCCA GGAAAATATGCGAAGTTCTCCAAACCCATTTATTACTGGCTTGACCAGGACAAATCCTTTCAGTGACAGGACTGCTGCTCCTGGAAACCCATTTAGAGCC AAGTCTGAAGAATCAGAGGCAACTTCATGGTTCTCCAAAGAAGAGCCCGTTACTATCAGTCCTTTCCCTTCTCTGCAGCCTCTTGGTCATAACAAAAGCA GGGCTTCATCTTCACTTGATGGCTTTAAGGACAGTTTTGATCTACAGGGCCAGTCTACATTAAAAATTAGCAACCCGAAAGGATGGGTAACCTTCGAGGA AGAAGAGGATTTTGGTGTGAAAGGGAAGTCAAAGTCAGCTTGTTCAGACTTACTGGGTAATCAGCCAAGTTCATTTTCTGGCTCCAACCTGACATTGAAT GATGACTGGAATAAAGGTACAAATGTCTCCTTCTGTGTGTTGCCGTCAAGAAGACCTCCTCCACCTCCTGTCCCTCTGCTCCCGCCCGGCACCAGCCCTC CAGTAGATCCTTTCACGACCTTGGCCTCTAAGGCTTCACCCACACTGGACTTTACAGAAAGATAACGCCATGCAATAGAAAACAGTGGGTACTTGCTTTT GGCAGGATAGAGCTAAGAGAATTGGGCATTAGTATTTCATTATGTGCAATAAGTCATTGTAAGTGCACTGATATCTTCACAAAACACCACTATTTGATGT GTACAGAGTTGGACTATGTGTATATTGGAAATAAGGAAAAACCCTTCTCATTGTTAACTGGAGTTTTGATGTATTTCTCTTTGGATGAATAGGAGACAGT AGTAGCCATAAAAAGTACTTATACTTTAGAAAACAGTCCTTATTCAGAAACTTTTCGGTCAGTCTTCTGAAGAATCTCAAAAAGCCCACCCAACTTTCAG CTGACATTTCCACCAGCCCTCTCATACTTGTTAACAATTGGTATCTTTGAGTATTTACCAAAGAGCTGCCAAGGTTACAGTGAACAGAGTTTTGAAAGGC ATTGCTTTAAAGGAAAAAAGTATAGGTATGTGTACATATATAATACATACAAACACATGTACTTCTGTATACATTTACATATTTTTACAATTCATACTTT AATTTCTAGGCTATAACTCAGACCAAATTATACCTAAAAGTTCCAACAAAGTCCCTTTTTCAATATCACATTACCAAAAAGATGGCTGCAAATGTAATTT GGACCTTTCATTAATTTTGTTTTCAAAACTAGAATAATCTCACCACAGAATCAGAATTTTCTACCGTTCCACACCCAACCCCTTCAAATACACACAACCT TGTTACTTTTCACTCCAGCACCTTCATACGCTTTTCTCCAGGAGGAGGTTCTTGCAGCTGGAAACAGCCTATTTTGTGGTCACTGTCAAGTGGATGGATA TTCTAGCGCTCCCAAAAAAGCACTATGGCCTTATATGCAGGGAAGGCACATACCACCAAGTTCAATGAGAAATATTAGAGCTAACCGTACTCTCTTCTCT GCGTACGTTCGAGTATACGTTGCCCATATCCCTCCCATATTTTCTTTTTGCTGCTTTTGCTCTGGAACTTTGCTTTTAGCAGGGAAAGCAGCTGTCCCCT GAGTGCTTTGAATTGGGAATATACCCAGTGTGTGTTCTCCCCCCTCTTACGAGGCTACATAACACATCTATGATGCTGCTTTAAGTTTTTAGAGGCTATA CCTCAAAGTAGCTGCGGATTTTGTCTCCTGCACTGCCAATATGCAACTGATCCCGCTTTTATTAATTTTTTGAAGAAGTACACAGAATTTTTACAGAATG TAGTATTTTGATATCATTAAGTAAACCAATCAGAAAACTCCTTGAGCAATAGTTGTTTCTTTGTCAGTTTCAGTTACAATCATCTTTACCCATTAAGACT TACATTAACATTCCTTTTATATAAAGAGTTGTATATGTCCACCTAAATTCCTATGTCCACACTTAACCTTTAAAGATGTACATTGAGGGAATATCAAAAA ATAGCGTTCATGGCTACGAATATGTAGAATGTTAAAAGCACAGCAAACTGCACTGCACTTATAAAGCAAATCTATTAGAAAAAAAGCATTTTTCTAAATG CTCAAATGTTATCAAAATACTATATTTATAGAAGTAATCTTCTCTGTTAACAGCCAAGATTTGCTGTTAGAAATAACTCTTGTGAGTTTTATATTGTGCT TTTTGGAGGTTCTAATCATTTCAGCAGTAGCGTCTTAAACAGCAGTATTACTATAAGCAGTTGCTTCAAAATGTGAATTAACTTGTTGAAACTGTGGCTT TAACATCCATGTGACTAGTGTATATGGTATTTGCTCTCCATTAGCAAAATAATTCATTGTTAGGTAAACTTCACTAGTGCAAATTGCAGATCTGTGAGCA ATGTTTCCTATTGAATATAAACTACTGTCTAAAATATACATATCAGCAGCCCAGCCTTTATCAGGAAAATTATACTTGGCAAGTTGCTGAAAATGCACAA AGTTATGAAAGTTAAAGGTATGCTGCAAATAACTAGCCATTATTCTATGTATTATTAAATATTTACTAGTTCTGTTAAAAGCAGAGCAGAAGTTAGACAC TAAGGATCTCTTTGTGAACTCTGTGTTCTCTATATTAGATTGCTGTTTATATGTAAGAATTTTATTGCTTATGTGGCATACAATATTTATAACTATAAAC TTTATAGAAGTACAGTATTAAAGTCAGTGGTACACAGACATTCTGTACATATCCTGTGAAACGTGCTGTCATATGAAATAAATATATCTGTCTTTAC

refseq_SYNJ1.F4 (forward primer)
refseq_SYNJ1.R4 (reverse primer)
Single exon skipping

Frame 0

EEEPEEEGCLRRKENGVQ*RIPDLSQIGSPTFQ PHSGN*A*GRMSHVRVWGCRCALICRKRGNQGYI LQSTGCIWTLRCSAVKSW*YYVTLSGPSHWMYV CWKNSRI*SFPSYFH*VYITANRFFR*GSHFRS AESFEFRKLLFCMVCIWHQFRFES*CAS*HARTD N***IFLESVFAFASQTLWREL**LVITSYVWR SRNQNNLCCS*TGEGLPHFKIKL*TSWDQV*CP GNK**WSCCQFCRNRTGCVLR*LSFFLHTNPRIC SIVLGATRVASGISSCPYVKGI*SQCTCF*QAF *NT*ELIW*TNNSKFAWI*GR*TYAK*SFPESF ESF*TCC*YPDGEF*LSSNG*GRKGRKIT*CS*T SSPEVSRLWIFLFQWK*SSKMPEWYSSNKLLGL S**NK*CAGISWLRDAS*TVGSSWFS*KASVGD SLSRSFSVNVVREW*FNQ*DICRNWSS*RESEVK RWCSLCYPNNSE*LL*QLQARGH*CFATGKYSE **FS*QSSSTFNYWKFACF*ADITVSIF*STKE HV*EFLQIFKA*ENSSMCRNLECEWWEAISQHSF *ESDTH*LAS*CTQVSWHPGVSR*KK*AN*YIC NWF*RNGRIECWKHCECKHNKSEALGCRTSEDN LQRQQVCAAGF*TVGGRLFVCFYQTTACSFYQGC CS*YCEDWNGRCNWK*GSSCNPNALPYNQPLLR L*PLCCRAVTSQRKK*RFYRNSTKIEFSYGKDA IFP*LCILVW*FQLSNRSP*RRS*RAHKTAKLGF SYSRRSTYQSEKCWTGF*RIFRRKGNLCSDI*V *LVF*RL*HQ*KVPHPCLDRPCPLEKEEMAF** IS*RSRSSKC*FSR*KQNSVHVDSRHFAALWKS* AEDF*PQACRCPD*YRYI*S*S*REAKHL*RSN CSSGSTRWYSIGLNQKFFTRK*FF**CLD**AS AAVCKFW*SYTYKICRR*NVGYIFGGKLCLECSE PKW*RVIESDYNYCFKKSRLDQKFGRRNEFREN *HCIAIINKLYPAW*RCRGCSRF*YGR*C**L* C*SGGTSSSASPAIFKFRPWYFPQLFTPN*SLPV TYNIRGSCTFPSHQTKPSTVKNSWASQCTEFSY *RAASNAAAAERPRPALGAQAAAAAPPGRPSHT PGSPTETSSAFRG*ESCTH*KGIWRYWSPSQSWG S*ERDGSTQKPWNNKER*YRTQSAFTSSRTCRP RTCWIQYSQTDDSSSCWSYQCPTEPRAGICWKT DS*KPKQNIRNVERFNFPS*TTEASGCFSSAVFF APACSKVARASCPCGSTYASVWPPAKFGNPTTT TTSKQVIP*LAFRSFLTTASKNKWNL*WQKRIT IKD*PI*RSVI*SACCIKGSAICSNVTCSHPRPK EVDSVAFCNAK*CFEFCKLHANNASNSSSESIP GKYAKFSKPIYYWLDQDKSFQ*QDCCSWKPI*S QV*RIRGNFMVLQRRARYYQSFPFSAASWS*QKQ GFIFT*WL*GQF*STGPVYIKN*QPERMGNLRG RRGFWCEREVKVSLFRLTG*SAKFIFWLQPDIE **LE*RYKCLLLCVAVKKTSSTSCPSAPARHQPS SRSFHDLGL*GFTHTGLYRKITPCNRKQWVLAF GRIELRELGISISLCAISHCKCTDIFTKHHYLM CTELDYVYIGNKEKPFSLLTGVLMYFSLDE*ETV VAIKSTYTLENSPYSETFRSVF*RISKSPPNFQ LTFPPALSYLLTIGIFEYLPKSCQGYSEQSFER HCFKGKKYRYVYIYNTYKHMYFCIHLHIFTIHTL ISRL*LRPNYT*KFQQSPFFNITLPKRWLQM*F GPFINFVFKTRIISPQNQNFLPFHTQPLQIHTT LLLFTPAPSYAFLQEEVLAAGNSLFCGHCQVDGY SSAPKKALWPYMQGRHIPPSSMRNIRANRTLFS AYVRVYVAHIPPIFSFCCFCSGTLLLAGKAAVP *VL*IGNIPSVCSPPSYEAT*HIYDAALSF*RLY LKVAADFVSCTANMQLIPLLLIF*RSTQNFYRM *YFDIIK*TNQKTP*AIVVSLSVSVTIIFTH*D LH*HSFYIKSCICPPKFLCPHLTFKDVH*GNIKK *RSWLRICRMLKAQQTALHL*SKSIRKKAFF*M LKCYQNTIFIEVIFSVNSQDLLLEITLVSFILC FLEVLIISAVAS*TAVLL*AVASKCELTC*NCGF NIHVTSVYGICSPLAK*FIVR*TSLVQIADL*A MFPIEYKLLSKIYISAAQPLSGKLYLASC*KCT KL*KLKVCCK*LAIILCIIKYLLVLLKAEQKLDT KDLFVNSVFSILDCCLYVRILLLMWHTIFITIN FIEVQY*SQWYTDILYISCETCCHMK*IYLSL

Frame 1

RRSRRKRAASEERRMAFSKGFRIYHKLDPPPFS LIVETRHKEECLMFESGAVAVLSSAEKEAIKGT YSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMS VGKIQESEVFRVTSTEFISLRIDSSDEDRISEV RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQ TTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGG VEIRTIYAAHKQAKACLISRLSCERAGTRFNVR GTNDDGHVANFVETEQVVYLDDSVSSFIQIRGS VPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHF RTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHL KASEHAADIQMVNFDYHQMVKGGKAEKLHSVLK PQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDC LDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVT RFQEVFRSMWSVNGDSISKIYAGTGALEGKAKL KDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLN SDLADKARALLTTGSLRVSEQTLQSASSKVLKS MCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIA FKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFA IGFEEMVELNAGNIVSASTTNQKLWAVELQKTI SRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRD VAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFV CSHFAAGQSQVKERNEDFIEIARKLSFPMGRML FSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWD SLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKY DLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDR SAEDLDLLNASFQDESKILYTWTPGTLLHYGRA ELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI AVQGPPDGTVLVSIKSSLPENNFFDDALIDELL QQFASFGEVILIRFVEDKMWVTFLEGSSALNVL SLNGKELLNRTITIALKSPDWIKNLEEEMSLEKI SIALPSSTSSTLLGEDAEVAADFDMEGDVDDYS AEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQ SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI DAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTR PAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPG VARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGP GPAGYSTARPTIPPRAGVISAPQSHARASAGRL TPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS LPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQP PPRSRSSHSLPSEASSQPQVKTNGISDGKRESP LKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDP KRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQ ENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRA KSEESEATSWFSKEEPVTISPFPSLQPLGHNKS RASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEE EEDFGVKGKSKSACSDLLGNQPSSFSGSNLTLN DDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSP PVDPFTTLASKASPTLDFTER*RHAIENSGYLLL AG*S*ENWALVFHYVQ*VIVSALISSQNTTI*C VQSWTMCILEIRKNPSHC*LEF*CISLWMNRRQ **P*KVLIL*KTVLIQKLFGQSSEESQKAHPTFS *HFHQPSHTC*QLVSLSIYQRAAKVTVNRVLKG IALKEKSIGMCTYIIHTNTCTSVYIYIFLQFIL *FLGYNSDQIIPKSSNKVPFSISHYQKDGCKCNL DLSLILFSKLE*SHHRIRIFYRSTPNPFKYTQP CYFSLQHLHTLFSRRRFLQLETAYFVVTVKWMD ILALPKKHYGLICREGTYHQVQ*EILELTVLSSL RTFEYTLPISLPYFLFAAFALELCF*QGKQLSP ECFELGIYPVCVLPPLTRLHNTSMMLL*VFRGY TSK*LRILSPALPICN*SRFY*FFEEVHRIFTEC SILISLSKPIRKLLEQ*LFLCQFQLQSSLPIKT YINIPFI*RVVYVHLNSYVHT*PLKMYIEGISK NSVHGYEYVEC*KHSKLHCTYKANLLEKKHFSKC SNVIKILYL*K*SSLLTAKICC*K*LL*VLYCA FWRF*SFQQ*RLKQQYYYKQLLQNVN*LVETVA LTSM*LVYMVFALH*QNNSLLGKLH*CKLQICEQ CFLLNINYCLKYTYQQPSLYQENYTWQVAENAQ SYES*RYAANN*PLFYVLLNIY*FC*KQSRS*T LRISL*TLCSLY*IAVYM*EFYCLCGIQYL*L*T L*KYSIKVSGTQTFCTYPVKRAVI*NKYICLY

Frame 2

GGAGGRGLPPKKGEWRSVKDSGSITNWIPHLSA S*WKLGIRKNVSCSSLGLSLCSHLQKKRQSRVH TPKYWMHMDS*VFCG*ILVILCYIIWS*SLDVC LLEKFKNLKFSELLPLSLYHCESILQMRIAFQKC GKF*IQETFILHGLHLASV*I*VLMRIVACKNR QLIIDFSGISLCICISNTMA*IVMTGYYVLCVE E*KSEQFMLLINRRRLASFQD*AVNELGPGLMSG EQMMMVMLPIL*KQNRLCT*MTQFLPSYKSEDL FHCSGSNQGCKWDLIVSVCQGDLKPMHLLLTGI LEHLRTYMVNK***ICLDLRKVNIC*VKLSRVI* KLLNMLLISRW*ILTIIKWLREERQKNYIVFLN LKSRSF*IMDFFISMEVKFKDARVVQFEQTAWI VLIEQIVCRHFLA*RC*LNSWKLLV*LKSLSW*L AFKKFFGQCGP*MVIQSVRYMQELELLKGKRS* KMVLALLPEQFRITSLTAPSKRPLMFCYWEIL* IVI*LTKLEHF*LLEVCVFLSRHYSQHLLKY*RA CVRISTNIQSLRKFEYVSEPGM*MVGSNFAA*L LRIRHSLTGFLMHPS*LASRSFKIKEVSQLIYL QLVLKKW*N*MLETL*VQAQQIRSSGL*NFRRQS PETTSMCCWLLNSWWASVCLFLSDHSMLLLSGM LQLIL*RLEWEVQLEIREQLQSECSSIQPAFAS SVATLLQGSHKSKKEMKIL*K*HEN*VFLWEGCY FPMTMYFGVVISTIESISLTKKLKSS*DSKIGI LL*QEINLSIRKMLDRFLEDF*KER*PLLRHIS MTCFLTTMTPVKSAAPLPGQTVSFGEGGNGLLID QLKI*IF*MLVFKMKAKFCTRGLQALCCTMEEL S*RLLTTGLSLP*LI*IYLKLKLKRGKTFIKK* LQFRVHQMVQYWSQSKVLYQKIIFLMMP*LMSFC SSLQVLVKLYL*DL*KIKCGLHFWREALP*MF* A*MVKSY*IGL*LLL*KVQTGSKIWKKK*V*RK LALHCHHQQALPCLVKMQRLQQILIWKVMLMTIV LKWRNFFLSISSHLQVPALVLPPALHPELVPAS HLQYQRVLYLPFPSDQAEHRQELLGLPVHRVLL LTRSQQRRCRRKTPPSPWSPSGRRRPARSPLPHA RLPHRDLLRLQGLGVLHPLERNLEVLEPLPVLG *LGERWKHPKALEQQGKII*DAVSLHLKQDLQA QDLLDTVQPDRRFLLVLELSVPHRATRGHLLED* LLKAKAKHQKRRKVQLSFLNH*SLRLLFLRSLL CPRLLKGCKSLLSLWQHLCLSLAPSQIWKPHHN HHLEAGHPIACLQKLPHNRK*KQMESLMAKENHH *RLTHLKICHLICLLYQRLSYLFKRHLFPPQTQ RG*FSCLLQRKVMF*VL*VACQQCLQFQLGVNP RKICEVLQTHLLLA*PGQILSVTGLLLLETHLEP SLKNQRQLHGSPKKSPLLSVLSLLCSLLVITKA GLHLHLMALRTVLIYRASLH*KLATRKDG*PSR KKRILV*KGSQSQLVQTYWVISQVHFLAPT*H*M MTGIKVQMSPSVCCRQEDLLHLLSLCSRPAPAL Q*ILSRPWPLRLHPHWTLQKDNAMQ*KTVGTCF WQDRAKRIGH*YFIMCNKSL*VH*YLHKTPLFDV YRVGLCVYWK*GKTLLIVNWSFDVFLFG*IGDS SSHKKYLYFRKQSLFRNFSVSLLKNLKKPTQLS ADISTSPLILVNNWYL*VFTKELPRLQ*TEF*KA LL*RKKV*VCVHI*YIQTHVLLYTFTYFYNSYF NF*AITQTKLYLKVPTKSLFQYHITKKMAANVI WTFH*FCFQN*NNLTTESEFSTVPHPTPSNTHNL VTFHSSTFIRFSPGGGSCSWKQPILWSLSSGWI F*RSQKSTMALYAGKAHTTKFNEKY*S*PYSLL CVRSSIRCPYPSHIFFLLLLLWNFAFSRESSCPL SALNWEYTQCVFSPLLRGYITHL*CCFKFLEAI PQSSCGFCLLHCQYATDPAFINFLKKYTEFLQN VVF*YH*VNQSENSLSNSCFFVSFSYNHLYPLRL TLTFLLYKELYMST*IPMSTLNL*RCTLREYQK IAFMATNM*NVKSTANCTALIKQIY*KKSIFLN AQMLSKYYIYRSNLLC*QPRFAVRNNSCEFYIVL FGGSNHFSSSVLNSSITISSCFKM*INLLKLWL *HPCD*CIWYLLSISKIIHC*VNFTSANCRSVS NVSY*I*TTV*NIHISSPAFIRKIILGKLLKMHK VMKVKGMLQITSHYSMYY*IFTSSVKSRAEVRH *GSLCELCVLYIRLLFICKNFIAYVAYNIYNYK LYRSTVLKSVVHRHSVHIL*NVLSYEINISVF

Sequence NM_203446

GGGAGCTGCTGCGGCCAGACCCACGGGCAGCCGGGCGGGCGGACGCCTCCAAGACCAGTCTCTGCCTCCGCAGCGTCAGCGGGAGCGGGCTGCCTCCGAA GAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGCCTCATAGTGGAAACTAGGCATAAGGAAGAATGTC TCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTCATCTGCAGAAAAAGAGGCAATCAAGGGTACATACTCCAAAGTACTGGATGCATATGGACTCTTAGG TGTTCTGCGGTTAAATCTTGGTGATACTATGTTACATTATCTGGTCCTAGTCACTGGATGTATGTCTGTTGGAAAAATTCAAGAATCTGAAGTTTTCCGA GTTACTTCCACTGAGTTTATATCACTGCGAATCGATTCTTCAGATGAGGATCGCATTTCAGAAGTGCGGAAAGTTTTGAATTCAGGAAACTTTTATTTTG CATGGTCTGCATCTGGCATCAGTTTAGATTTGAGTCTTAATGCGCATCGTAGCATGCAAGAACAGACAACTGATAATAGATTTTTCTGGAATCAGTCTTT GCATTTGCATCTCAAACACTATGGCGTGAATTGTGATGACTGGTTATTACGTCTTATGTGTGGAGGAGTAGAAATCAGAACAATTTATGCTGCTCATAAA CAGGCGAAGGCTTGCCTCATTTCAAGATTAAGCTGTGAACGAGCTGGGACCAGGTTTAATGTCCGGGGAACAAATGATGATGGTCATGTTGCCAATTTTG TAGAAACAGAACAGGTTGTGTACTTAGATGACTCAGTTTCTTCCTTCATACAAATCCGAGGATCTGTTCCATTGTTCTGGGAGCAACCAGGGTTGCAAGT GGGATCTCATCGTGTCCGTATGTCAAGGGGATTTGAAGCCAATGCACCTGCTTTTGACAGGCATTTTAGAACACTTAAGAACTTATATGGTAAACAAATA ATAGTAAATTTGCTTGGATCTAAGGAAGGTGAACATATGCTAAGTAAAGCTTTCCAGAGTCATTTGAAAGCTTCTGAACATGCTGCTGATATCCAGATGG TGAATTTTGACTATCATCAAATGGTTAAGGGAGGAAAGGCAGAAAAATTACATAGTGTTCTTAAACCTCAAGTCCAGAAGTTTCTAGATTATGGATTTTT TTATTTCAATGGAAGTGAAGTTCAAAGATGCCAGAGTGGTACAGTTCGAACAAACTGCTTGGATTGTCTTGATAGAACAAATAGTGTGCAGGCATTTCTT GGCTTAGAGATGCTAGCTAAACAGTTGGAAGCTCTTGGTTTAGCTGAAAAGCCTCAGTTGGTGACTCGCTTTCAAGAAGTTTTTCGGTCAATGTGGTCCG TGAATGGTGATTCAATCAGTAAGATATATGCAGGAACTGGAGCTCTTGAAGGGAAAGCGAAGTTAAAAGATGGTGCTCGCTCTGTTACCCGAACAATTCA GAATAACTTCTTTGACAGCTCCAAGCAAGAGGCCATTGATGTTTTGCTACTGGGAAATACTCTGAATAGTGATTTAGCTGACAAAGCTCGAGCACTTTTA ACTACTGGAAGTTTGCGTGTTTCTGAGCAGACATTACAGTCAGCATCTTCTAAAGTACTAAAGAGCATGTGTGAGAATTTCTACAAATATTCAAAGCCTA AGAAAATTCGAGTATGTGTCGGAACCTGGAATGTGAATGGTGGGAAGCAATTTCGCAGCATAGCTTTTAAGAATCAGACACTCACTGACTGGCTTCTTGA TGCACCCAAGTTAGCTGGCATCCAGGAGTTTCAAGATAAAAGAAGTAAGCCAACTGATATATTTGCAATTGGTTTTGAAGAAATGGTAGAATTGAATGCT GGAAACATTGTGAGTGCAAGCACAACAAATCAGAAGCTCTGGGCTGTAGAACTTCAGAAGACAATCTCCAGAGACAACAAGTATGTGCTGCTGGCTTCTG AACAGTTGGTGGGCGTCTGTTTGTTTGTTTTTATCAGACCACAGCATGCTCCTTTTATCAGGGATGTTGCAGTTGATACTGTGAAGACTGGAATGGGAGG TGCAACTGGAAATAAGGGAGCAGTTGCAATCCGAATGCTCTTCCATACAACCAGCCTTTGCTTCGTCTGTAGCCACTTTGCTGCAGGGCAGTCACAAGTC AAAGAAAGAAATGAAGATTTTATAGAAATAGCACGAAAATTGAGTTTTCCTATGGGAAGGATGCTATTTTCCCATGACTATGTATTTTGGTGTGGTGATT TCAACTATCGAATCGATCTCCCTAACGAAGAAGTTAAAGAGCTCATAAGACAGCAAAATTGGGATTCTCTTATAGCAGGAGATCAACTTATCAATCAGAA AAATGCTGGACAGGTTTTTAGAGGATTTTTAGAAGGAAAGGTAACCTTTGCTCCGACATATAAGTATGACTTGTTTTCTGACGACTATGACACCAGTGAA AAGTGCCGCACCCCTGCCTGGACAGACCGTGTCCTTTGGAGAAGGAGGAAATGGCCTTTTGATAGATCAGCTGAAGATCTAGATCTTCTAAATGCTAGTT TTCAAGATGAAAGCAAAATTCTGTACACGTGGACTCCAGGCACTTTGCTGCACTATGGAAGAGCTGAGCTGAAGACTTCTGACCACAGGCCTGTCGTTGC CCTGATTGATATAGATATATTTGAAGTTGAAGCTGAAGAGAGGCAAAACATTTATAAAGAAGTAATTGCAGTTCAGGGTCCACCAGATGGTACAGTATTG GTCTCAATCAAAAGTTCTTTACCAGAAAATAATTTTTTTGATGATGCCTTGATTGATGAGCTTCTGCAGCAGTTTGCAAGTTTTGGTGAAGTTATACTTA TAAGATTTGTAGAAGATAAAATGTGGGTTACATTTTTGGAGGGAAGCTCTGCCTTGAATGTTCTGAGCCTAAATGGTAAAGAGTTATTGAATCGGACTAT AACTATTGCTTTAAAAAGTCCAGACTGGATCAAAAATTTGGAAGAAGAAATGAGTTTAGAGAAAATTAGCATTGCATTGCCATCATCAACAAGCTCTACC CTGCTTGGTGAAGATGCAGAGGTTGCAGCAGATTTTGATATGGAAGGTGATGTTGATGACTATAGTGCTGAAGTGGAGGAACTTCTTCCTCAGCATCTCC AGCCATCTTCAAGTTCCGGCCTTGGTACTTCCCCCAGCTCTTCACCCCGAACTAGTCCCTGCCAGTCACCTACAATATCAGAGGGTCCTGTACCTTCCCT TCCCATCAGACCAAGCCGAGCACCGTCAAGAACTCCTGGGCCTCCCAGTGCACAGAGTTCTCCTATTGACGCGCAGCCAGCAACGCCGCTGCCGCAGAAA GACCCCGCCCAGCCCTTGGAGCCCAAGCGGCCGCCGCCGCCCCGCCCGGTCGCCCCTCCCACACGCCCGGCTCCCCCACAGAGACCTCCTCCGCCTTCAG GGGCTAGGAGTCCTGCACCCACTAGAAAGGAATTTGGAGCACCCAAAAGCCCTGGAACAACAAGGAAAGATAATATAGGACGCAGTCAGCCTTCACCTCA AGCAGGACTTGCAGGCCCAGGACCTGCTGGATACAGTACAGCCAGACCGACGATTCCTCCTCGTGCTGGAGTTATCAGTGCCCCACAGAGCCACGCGCGG GCATCTGCTGGAAGACTGACTCCTGAAAGCCAAAGCAAAACATCAGAAACGTCGAAAGGTTCAACTTTCCTTCCTGAACCACTGAAGCCTCAGGCTGCTT TTCCTCCGCAGTCTTCTTTGCCCCCGCCTGCTCAAAGGTTGCAAGAGCCTCTTGTCCCTGTGGCAGCACCTATGCCTCAGTCTGGCCCCCAGCCAAATTT GGAAACCCCACCACAACCACCACCTCGAAGCAGGTCATCCCATAGCTTGCCTTCAGAAGCTTCCTCACAACCGCAACAGGAGCAACCATCAGGGTAACAG GTAAAAACAAATGGAATCTCTGATGGCAAAAGAGAATCACCATTAAAGATTGACCCATTTGAAGATCTGTCATTTAATCTGCTTGCTGTATCAAAGGCTC AGCTATCTGTTCAAACGTCACCTGTTCCCACCCCAGACCCAAAGAGGTTGATTCAGTTGCCTTCTGCAACGCAAAGTAATGTTTTGAGTTCTGTAAGTTG CATGCCAACAATGCCTCCAATTCCAGCTCGGAGTCAATCCCAGGAAAATATGCGAAGTTCTCCAAACCCATTTATTACTGGCTTGACCAGGACAAATCCT TTCAGTGACAGGACTGCTGCTCCTGGAAACCCATTTAGAGCCAAGTCTGAAGAATCAGAGGCAACTTCATGGTTCTCCAAAGAAGAGCCCGTTACTATCA GTCCTTTCCCTTCTCTGCAGCCTCTTGGTCATAACAAAAGCAGGGCTTCATCTTCACTTGATGGCTTTAAGGACAGTTTTGATCTACAGGGCCAGTCTAC ATTAAAAATTAGCAACCCGAAAGGATGGGTAACCTTCGAGGAAGAAGAGGATTTTGGTGTGAAAGGGAAGTCAAAGTCAGCTTGTTCAGACTTACTGGGT AATCAGCCAAGTTCATTTTCTGGCTCCAACCTGACATTGAATGATGACTGGAATAAAGGTACAAATGTCTCCTTCTGTGTGTTGCCGTCAAGAAGACCTC CTCCACCTCCTGTCCCTCTGCTCCCGCCCGGCACCAGCCCTCCAGTAGATCCTTTCACGACCTTGGCCTCTAAGGCTTCACCCACACTGGACTTTACAGA AAGATAACGCCATGCAATAGAAAACAGTGGGTACTTGCTTTTGGCAGGATAGAGCTAAGAGAATTGGGCATTAGTATTTCATTATGTGCAATAAGTCATT GTAAGTGCACTGATATCTTCACAAAACACCACTATTTGATGTGTACAGAGTTGGACTATGTGTATATTGGAAATAAGGAAAAACCCTTCTCATTGTTAAC TGGAGTTTTGATGTATTTCTCTTTGGATGAATAGGAGACAGTAGTAGCCATAAAAAGTACTTATACTTTAGAAAACAGTCCTTATTCAGAAACTTTTCGG TCAGTCTTCTGAAGAATCTCAAAAAGCCCACCCAACTTTCAGCTGACATTTCCACCAGCCCTCTCATACTTGTTAACAATTGGTATCTTTGAGTATTTAC CAAAGAGCTGCCAAGGTTACAGTGAACAGAGTTTTGAAAGGCATTGCTTTAAAGGAAAAAAGTATAGGTATGTGTACATATATAATACATACAAACACAT GTACTTCTGTATACATTTACATATTTTTACAATTCATACTTTAATTTCTAGGCTATAACTCAGACCAAATTATACCTAAAAGTTCCAACAAAGTCCCTTT TTCAATATCACATTACCAAAAAGATGGCTGCAAATGTAATTTGGACCTTTCATTAATTTTGTTTTCAAAACTAGAATAATCTCACCACAGAATCAGAATT TTCTACCGTTCCACACCCAACCCCTTCAAATACACACAACCTTGTTACTTTTCACTCCAGCACCTTCATACGCTTTTCTCCAGGAGGAGGTTCTTGCAGC TGGAAACAGCCTATTTTGTGGTCACTGTCAAGTGGATGGATATTCTAGCGCTCCCAAAAAAGCACTATGGCCTTATATGCAGGGAAGGCACATACCACCA AGTTCAATGAGAAATATTAGAGCTAACCGTACTCTCTTCTCTGCGTACGTTCGAGTATACGTTGCCCATATCCCTCCCATATTTTCTTTTTGCTGCTTTT GCTCTGGAACTTTGCTTTTAGCAGGGAAAGCAGCTGTCCCCTGAGTGCTTTGAATTGGGAATATACCCAGTGTGTGTTCTCCCCCCTCTTACGAGGCTAC ATAACACATCTATGATGCTGCTTTAAGTTTTTAGAGGCTATACCTCAAAGTAGCTGCGGATTTTGTCTCCTGCACTGCCAATATGCAACTGATCCCGCTT TTATTAATTTTTTGAAGAAGTACACAGAATTTTTACAGAATGTAGTATTTTGATATCATTAAGTAAACCAATCAGAAAACTCCTTGAGCAATAGTTGTTT CTTTGTCAGTTTCAGTTACAATCATCTTTACCCATTAAGACTTACATTAACATTCCTTTTATATAAAGAGTTGTATATGTCCACCTAAATTCCTATGTCC ACACTTAACCTTTAAAGATGTACATTGAGGGAATATCAAAAAATAGCGTTCATGGCTACGAATATGTAGAATGTTAAAAGCACAGCAAACTGCACTGCAC TTATAAAGCAAATCTATTAGAAAAAAAGCATTTTTCTAAATGCTCAAATGTTATCAAAATACTATATTTATAGAAGTAATCTTCTCTGTTAACAGCCAAG ATTTGCTGTTAGAAATAACTCTTGTGAGTTTTATATTGTGCTTTTTGGAGGTTCTAATCATTTCAGCAGTAGCGTCTTAAACAGCAGTATTACTATAAGC AGTTGCTTCAAAATGTGAATTAACTTGTTGAAACTGTGGCTTTAACATCCATGTGACTAGTGTATATGGTATTTGCTCTCCATTAGCAAAATAATTCATT GTTAGGTAAACTTCACTAGTGCAAATTGCAGATCTGTGAGCAATGTTTCCTATTGAATATAAACTACTGTCTAAAATATACATATCAGCAGCCCAGCCTT TATCAGGAAAATTATACTTGGCAAGTTGCTGAAAATGCACAAAGTTATGAAAGTTAAAGGTATGCTGCAAATAACTAGCCATTATTCTATGTATTATTAA ATATTTACTAGTTCTGTTAAAAGCAGAGCAGAAGTTAGACACTAAGGATCTCTTTGTGAACTCTGTGTTCTCTATATTAGATTGCTGTTTATATGTAAGA ATTTTATTGCTTATGTGGCATACAATATTTATAACTATAAACTTTATAGAAGTACAGTATTAAAGTCAGTGGTACACAGACATTCTGTACATATCCTGTG AAACGTGCTGTCATATGAAATAAATATATCTGTCTTTAC

refseq_SYNJ1.F4 (forward primer)
refseq_SYNJ1.R4 (reverse primer)
Single exon skipping

Frame 0

GSCCGQTHGQPGGRTPPRPVSASAASAGAGCLR RKENGVQ*RIPDLSQIGSPTFQPHSGN*A*GRMS HVRVWGCRCALICRKRGNQGYILQSTGCIWTLR CSAVKSW*YYVTLSGPSHWMYVCWKNSRI*SFP SYFH*VYITANRFFR*GSHFRSAESFEFRKLLFC MVCIWHQFRFES*CAS*HARTDN***IFLESVF AFASQTLWREL**LVITSYVWRSRNQNNLCCS* TGEGLPHFKIKL*TSWDQV*CPGNK**WSCCQFC RNRTGCVLR*LSFFLHTNPRICSIVLGATRVAS GISSCPYVKGI*SQCTCF*QAF*NT*ELIW*TN NSKFAWI*GR*TYAK*SFPESFESF*TCC*YPDG EF*LSSNG*GRKGRKIT*CS*TSSPEVSRLWIF LFQWK*SSKMPEWYSSNKLLGLS**NK*CAGIS WLRDAS*TVGSSWFS*KASVGDSLSRSFSVNVVR EW*FNQ*DICRNWSS*RESEVKRWCSLCYPNNS E*LL*QLQARGH*CFATGKYSE**FS*QSSSTF NYWKFACF*ADITVSIF*STKEHV*EFLQIFKA* ENSSMCRNLECEWWEAISQHSF*ESDTH*LAS* CTQVSWHPGVSR*KK*AN*YICNWF*RNGRIEC WKHCECKHNKSEALGCRTSEDNLQRQQVCAAGF* TVGGRLFVCFYQTTACSFYQGCCS*YCEDWNGR CNWK*GSSCNPNALPYNQPLLRL*PLCCRAVTS QRKK*RFYRNSTKIEFSYGKDAIFP*LCILVW*F QLSNRSP*RRS*RAHKTAKLGFSYSRRSTYQSE KCWTGF*RIFRRKGNLCSDI*V*LVF*RL*HQ* KVPHPCLDRPCPLEKEEMAF**IS*RSRSSKC*F SR*KQNSVHVDSRHFAALWKS*AEDF*PQACRC PD*YRYI*S*S*REAKHL*RSNCSSGSTRWYSI GLNQKFFTRK*FF**CLD**ASAAVCKFW*SYTY KICRR*NVGYIFGGKLCLECSEPKW*RVIESDY NYCFKKSRLDQKFGRRNEFREN*HCIAIINKLY PAW*RCRGCSRF*YGR*C**L*C*SGGTSSSASP AIFKFRPWYFPQLFTPN*SLPVTYNIRGSCTFP SHQTKPSTVKNSWASQCTEFSY*RAASNAAAAE RPRPALGAQAAAAAPPGRPSHTPGSPTETSSAFR G*ESCTH*KGIWSTQKPWNNKER*YRTQSAFTS SRTCRPRTCWIQYSQTDDSSSCWSYQCPTEPRA GICWKTDS*KPKQNIRNVERFNFPS*TTEASGCF SSAVFFAPACSKVARASCPCGSTYASVWPPAKF GNPTTTTTSKQVIP*LAFRSFLTTATGATIRVT GKNKWNL*WQKRITIKD*PI*RSVI*SACCIKGS AICSNVTCSHPRPKEVDSVAFCNAK*CFEFCKL HANNASNSSSESIPGKYAKFSKPIYYWLDQDKS FQ*QDCCSWKPI*SQV*RIRGNFMVLQRRARYYQ SFPFSAASWS*QKQGFIFT*WL*GQF*STGPVY IKN*QPERMGNLRGRRGFWCEREVKVSLFRLTG *SAKFIFWLQPDIE**LE*RYKCLLLCVAVKKTS STSCPSAPARHQPSSRSFHDLGL*GFTHTGLYR KITPCNRKQWVLAFGRIELRELGISISLCAISH CKCTDIFTKHHYLMCTELDYVYIGNKEKPFSLLT GVLMYFSLDE*ETVVAIKSTYTLENSPYSETFR SVF*RISKSPPNFQLTFPPALSYLLTIGIFEYL PKSCQGYSEQSFERHCFKGKKYRYVYIYNTYKHM YFCIHLHIFTIHTLISRL*LRPNYT*KFQQSPF FNITLPKRWLQM*FGPFINFVFKTRIISPQNQN FLPFHTQPLQIHTTLLLFTPAPSYAFLQEEVLAA GNSLFCGHCQVDGYSSAPKKALWPYMQGRHIPP SSMRNIRANRTLFSAYVRVYVAHIPPIFSFCCF CSGTLLLAGKAAVP*VL*IGNIPSVCSPPSYEAT *HIYDAALSF*RLYLKVAADFVSCTANMQLIPL LLIF*RSTQNFYRM*YFDIIK*TNQKTP*AIVV SLSVSVTIIFTH*DLH*HSFYIKSCICPPKFLCP HLTFKDVH*GNIKK*RSWLRICRMLKAQQTALH L*SKSIRKKAFF*MLKCYQNTIFIEVIFSVNSQ DLLLEITLVSFILCFLEVLIISAVAS*TAVLL*A VASKCELTC*NCGFNIHVTSVYGICSPLAK*FI VR*TSLVQIADL*AMFPIEYKLLSKIYISAAQP LSGKLYLASC*KCTKL*KLKVCCK*LAIILCIIK YLLVLLKAEQKLDTKDLFVNSVFSILDCCLYVR ILLLMWHTIFITINFIEVQY*SQWYTDILYISC ETCCHMK*IYLSL

Frame 1

GAAAARPTGSRAGGRLQDQSLPPQRQRERAASE ERRMAFSKGFRIYHKLDPPPFSLIVETRHKEEC LMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLG VLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFR VTSTEFISLRIDSSDEDRISEVRKVLNSGNFYF AWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSL HLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHK QAKACLISRLSCERAGTRFNVRGTNDDGHVANF VETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQV GSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQI IVNLLGSKEGEHMLSKAFQSHLKASEHAADIQM VNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFF YFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFL GLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWS VNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQ NNFFDSSKQEAIDVLLLGNTLNSDLADKARALL TTGSLRVSEQTLQSASSKVLKSMCENFYKYSKP KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLD APKLAGIQEFQDKRSKPTDIFAIGFEEMVELNA GNIVSASTTNQKLWAVELQKTISRDNKYVLLAS EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGG ATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQV KERNEDFIEIARKLSFPMGRMLFSHDYVFWCGD FNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQK NAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSE KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVA LIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVL VSIKSSLPENNFFDDALIDELLQQFASFGEVIL IRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTI TIALKSPDWIKNLEEEMSLEKISIALPSSTSST LLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSL PIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS GARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQ AGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAA FPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNL ETPPQPPPRSRSSHSLPSEASSQPQQEQPSG*Q VKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA QLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSC MPTMPPIPARSQSQENMRSSPNPFITGLTRTNP FSDRTAAPGNPFRAKSEESEATSWFSKEEPVTI SPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQST LKISNPKGWVTFEEEEDFGVKGKSKSACSDLLG NQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRP PPPPVPLLPPGTSPPVDPFTTLASKASPTLDFTE R*RHAIENSGYLLLAG*S*ENWALVFHYVQ*VI VSALISSQNTTI*CVQSWTMCILEIRKNPSHC* LEF*CISLWMNRRQ**P*KVLIL*KTVLIQKLFG QSSEESQKAHPTFS*HFHQPSHTC*QLVSLSIY QRAAKVTVNRVLKGIALKEKSIGMCTYIIHTNT CTSVYIYIFLQFIL*FLGYNSDQIIPKSSNKVPF SISHYQKDGCKCNLDLSLILFSKLE*SHHRIRI FYRSTPNPFKYTQPCYFSLQHLHTLFSRRRFLQ LETAYFVVTVKWMDILALPKKHYGLICREGTYHQ VQ*EILELTVLSSLRTFEYTLPISLPYFLFAAF ALELCF*QGKQLSPECFELGIYPVCVLPPLTRL HNTSMMLL*VFRGYTSK*LRILSPALPICN*SRF Y*FFEEVHRIFTECSILISLSKPIRKLLEQ*LF LCQFQLQSSLPIKTYINIPFI*RVVYVHLNSYV HT*PLKMYIEGISKNSVHGYEYVEC*KHSKLHCT YKANLLEKKHFSKCSNVIKILYL*K*SSLLTAK ICC*K*LL*VLYCAFWRF*SFQQ*RLKQQYYYK QLLQNVN*LVETVALTSM*LVYMVFALH*QNNSL LGKLH*CKLQICEQCFLLNINYCLKYTYQQPSL YQENYTWQVAENAQSYES*RYAANN*PLFYVLL NIY*FC*KQSRS*TLRISL*TLCSLY*IAVYM*E FYCLCGIQYL*L*TL*KYSIKVSGTQTFCTYPV KRAVI*NKYICLY

Frame 2

ELLRPDPRAAGRADASKTSLCLRSVSGSGLPPK KGEWRSVKDSGSITNWIPHLSAS*WKLGIRKNV SCSSLGLSLCSHLQKKRQSRVHTPKYWMHMDS* VFCG*ILVILCYIIWS*SLDVCLLEKFKNLKFSE LLPLSLYHCESILQMRIAFQKCGKF*IQETFIL HGLHLASV*I*VLMRIVACKNRQLIIDFSGISL CICISNTMA*IVMTGYYVLCVEE*KSEQFMLLIN RRRLASFQD*AVNELGPGLMSGEQMMMVMLPIL *KQNRLCT*MTQFLPSYKSEDLFHCSGSNQGCK WDLIVSVCQGDLKPMHLLLTGILEHLRTYMVNK* **ICLDLRKVNIC*VKLSRVI*KLLNMLLISRW *ILTIIKWLREERQKNYIVFLNLKSRSF*IMDF FISMEVKFKDARVVQFEQTAWIVLIEQIVCRHFL A*RC*LNSWKLLV*LKSLSW*LAFKKFFGQCGP *MVIQSVRYMQELELLKGKRS*KMVLALLPEQF RITSLTAPSKRPLMFCYWEIL*IVI*LTKLEHF* LLEVCVFLSRHYSQHLLKY*RACVRISTNIQSL RKFEYVSEPGM*MVGSNFAA*LLRIRHSLTGFL MHPS*LASRSFKIKEVSQLIYLQLVLKKW*N*ML ETL*VQAQQIRSSGL*NFRRQSPETTSMCCWLL NSWWASVCLFLSDHSMLLLSGMLQLIL*RLEWE VQLEIREQLQSECSSIQPAFASSVATLLQGSHKS KKEMKIL*K*HEN*VFLWEGCYFPMTMYFGVVI STIESISLTKKLKSS*DSKIGILL*QEINLSIR KMLDRFLEDF*KER*PLLRHISMTCFLTTMTPVK SAAPLPGQTVSFGEGGNGLLIDQLKI*IF*MLV FKMKAKFCTRGLQALCCTMEELS*RLLTTGLSL P*LI*IYLKLKLKRGKTFIKK*LQFRVHQMVQYW SQSKVLYQKIIFLMMP*LMSFCSSLQVLVKLYL *DL*KIKCGLHFWREALP*MF*A*MVKSY*IGL *LLL*KVQTGSKIWKKK*V*RKLALHCHHQQALP CLVKMQRLQQILIWKVMLMTIVLKWRNFFLSIS SHLQVPALVLPPALHPELVPASHLQYQRVLYLP FPSDQAEHRQELLGLPVHRVLLLTRSQQRRCRRK TPPSPWSPSGRRRPARSPLPHARLPHRDLLRLQ GLGVLHPLERNLEHPKALEQQGKII*DAVSLHL KQDLQAQDLLDTVQPDRRFLLVLELSVPHRATRG HLLED*LLKAKAKHQKRRKVQLSFLNH*SLRLL FLRSLLCPRLLKGCKSLLSLWQHLCLSLAPSQI WKPHHNHHLEAGHPIACLQKLPHNRNRSNHQGNR *KQMESLMAKENHH*RLTHLKICHLICLLYQRL SYLFKRHLFPPQTQRG*FSCLLQRKVMF*VL*V ACQQCLQFQLGVNPRKICEVLQTHLLLA*PGQIL SVTGLLLLETHLEPSLKNQRQLHGSPKKSPLLS VLSLLCSLLVITKAGLHLHLMALRTVLIYRASL H*KLATRKDG*PSRKKRILV*KGSQSQLVQTYWV ISQVHFLAPT*H*MMTGIKVQMSPSVCCRQEDL LHLLSLCSRPAPALQ*ILSRPWPLRLHPHWTLQ KDNAMQ*KTVGTCFWQDRAKRIGH*YFIMCNKSL *VH*YLHKTPLFDVYRVGLCVYWK*GKTLLIVN WSFDVFLFG*IGDSSSHKKYLYFRKQSLFRNFS VSLLKNLKKPTQLSADISTSPLILVNNWYL*VFT KELPRLQ*TEF*KALL*RKKV*VCVHI*YIQTH VLLYTFTYFYNSYFNF*AITQTKLYLKVPTKSL FQYHITKKMAANVIWTFH*FCFQN*NNLTTESEF STVPHPTPSNTHNLVTFHSSTFIRFSPGGGSCS WKQPILWSLSSGWIF*RSQKSTMALYAGKAHTT KFNEKY*S*PYSLLCVRSSIRCPYPSHIFFLLLL LWNFAFSRESSCPLSALNWEYTQCVFSPLLRGY ITHL*CCFKFLEAIPQSSCGFCLLHCQYATDPA FINFLKKYTEFLQNVVF*YH*VNQSENSLSNSCF FVSFSYNHLYPLRLTLTFLLYKELYMST*IPMS TLNL*RCTLREYQKIAFMATNM*NVKSTANCTA LIKQIY*KKSIFLNAQMLSKYYIYRSNLLC*QPR FAVRNNSCEFYIVLFGGSNHFSSSVLNSSITIS SCFKM*INLLKLWL*HPCD*CIWYLLSISKIIH C*VNFTSANCRSVSNVSY*I*TTV*NIHISSPAF IRKIILGKLLKMHKVMKVKGMLQITSHYSMYY* IFTSSVKSRAEVRH*GSLCELCVLYIRLLFICK NFIAYVAYNIYNYKLYRSTVLKSVVHRHSVHIL* NVLSYEINISVF