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Sequence NM_203446
GGGAGCTGCTGCGGCCAGACCCACGGGCAGCCGGGCGGGCGGACGCCTCCAAGACCAGTCTCTGCCTCCGCAGCGTCAGCGGGAGCGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGCCTCATAGTGGAAACTAGGCATAAGGAAGAATGTC
TCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTCATCTGCAGAAAAAGAGGCAATCAAGGGTACATACTCCAAAGTACTGGATGCATATGGACTCTTAGG
TGTTCTGCGGTTAAATCTTGGTGATACTATGTTACATTATCTGGTCCTAGTCACTGGATGTATGTCTGTTGGAAAAATTCAAGAATCTGAAGTTTTCCGA
GTTACTTCCACTGAGTTTATATCACTGCGAATCGATTCTTCAGATGAGGATCGCATTTCAGAAGTGCGGAAAGTTTTGAATTCAGGAAACTTTTATTTTG
CATGGTCTGCATCTGGCATCAGTTTAGATTTGAGTCTTAATGCGCATCGTAGCATGCAAGAACAGACAACTGATAATAGATTTTTCTGGAATCAGTCTTT
GCATTTGCATCTCAAACACTATGGCGTGAATTGTGATGACTGGTTATTACGTCTTATGTGTGGAGGAGTAGAAATCAGAACAATTTATGCTGCTCATAAA
CAGGCGAAGGCTTGCCTCATTTCAAGATTAAGCTGTGAACGAGCTGGGACCAGGTTTAATGTCCGGGGAACAAATGATGATGGTCATGTTGCCAATTTTG
TAGAAACAGAACAGGTTGTGTACTTAGATGACTCAGTTTCTTCCTTCATACAAATCCGAGGATCTGTTCCATTGTTCTGGGAGCAACCAGGGTTGCAAGT
GGGATCTCATCGTGTCCGTATGTCAAGGGGATTTGAAGCCAATGCACCTGCTTTTGACAGGCATTTTAGAACACTTAAGAACTTATATGGTAAACAAATA
ATAGTAAATTTGCTTGGATCTAAGGAAGGTGAACATATGCTAAGTAAAGCTTTCCAGAGTCATTTGAAAGCTTCTGAACATGCTGCTGATATCCAGATGG
TGAATTTTGACTATCATCAAATGGTTAAGGGAGGAAAGGCAGAAAAATTACATAGTGTTCTTAAACCTCAAGTCCAGAAGTTTCTAGATTATGGATTTTT
TTATTTCAATGGAAGTGAAGTTCAAAGATGCCAGAGTGGTACAGTTCGAACAAACTGCTTGGATTGTCTTGATAGAACAAATAGTGTGCAGGCATTTCTT
GGCTTAGAGATGCTAGCTAAACAGTTGGAAGCTCTTGGTTTAGCTGAAAAGCCTCAGTTGGTGACTCGCTTTCAAGAAGTTTTTCGGTCAATGTGGTCCG
TGAATGGTGATTCAATCAGTAAGATATATGCAGGAACTGGAGCTCTTGAAGGGAAAGCGAAGTTAAAAGATGGTGCTCGCTCTGTTACCCGAACAATTCA
GAATAACTTCTTTGACAGCTCCAAGCAAGAGGCCATTGATGTTTTGCTACTGGGAAATACTCTGAATAGTGATTTAGCTGACAAAGCTCGAGCACTTTTA
ACTACTGGAAGTTTGCGTGTTTCTGAGCAGACATTACAGTCAGCATCTTCTAAAGTACTAAAGAGCATGTGTGAGAATTTCTACAAATATTCAAAGCCTA
AGAAAATTCGAGTATGTGTCGGAACCTGGAATGTGAATGGTGGGAAGCAATTTCGCAGCATAGCTTTTAAGAATCAGACACTCACTGACTGGCTTCTTGA
TGCACCCAAGTTAGCTGGCATCCAGGAGTTTCAAGATAAAAGAAGTAAGCCAACTGATATATTTGCAATTGGTTTTGAAGAAATGGTAGAATTGAATGCT
GGAAACATTGTGAGTGCAAGCACAACAAATCAGAAGCTCTGGGCTGTAGAACTTCAGAAGACAATCTCCAGAGACAACAAGTATGTGCTGCTGGCTTCTG
AACAGTTGGTGGGCGTCTGTTTGTTTGTTTTTATCAGACCACAGCATGCTCCTTTTATCAGGGATGTTGCAGTTGATACTGTGAAGACTGGAATGGGAGG
TGCAACTGGAAATAAGGGAGCAGTTGCAATCCGAATGCTCTTCCATACAACCAGCCTTTGCTTCGTCTGTAGCCACTTTGCTGCAGGGCAGTCACAAGTC
AAAGAAAGAAATGAAGATTTTATAGAAATAGCACGAAAATTGAGTTTTCCTATGGGAAGGATGCTATTTTCCCATGACTATGTATTTTGGTGTGGTGATT
TCAACTATCGAATCGATCTCCCTAACGAAGAAGTTAAAGAGCTCATAAGACAGCAAAATTGGGATTCTCTTATAGCAGGAGATCAACTTATCAATCAGAA
AAATGCTGGACAGGTTTTTAGAGGATTTTTAGAAGGAAAGGTAACCTTTGCTCCGACATATAAGTATGACTTGTTTTCTGACGACTATGACACCAGTGAA
AAGTGCCGCACCCCTGCCTGGACAGACCGTGTCCTTTGGAGAAGGAGGAAATGGCCTTTTGATAGATCAGCTGAAGATCTAGATCTTCTAAATGCTAGTT
TTCAAGATGAAAGCAAAATTCTGTACACGTGGACTCCAGGCACTTTGCTGCACTATGGAAGAGCTGAGCTGAAGACTTCTGACCACAGGCCTGTCGTTGC
CCTGATTGATATAGATATATTTGAAGTTGAAGCTGAAGAGAGGCAAAACATTTATAAAGAAGTAATTGCAGTTCAGGGTCCACCAGATGGTACAGTATTG
GTCTCAATCAAAAGTTCTTTACCAGAAAATAATTTTTTTGATGATGCCTTGATTGATGAGCTTCTGCAGCAGTTTGCAAGTTTTGGTGAAGTTATACTTA
TAAGATTTGTAGAAGATAAAATGTGGGTTACATTTTTGGAGGGAAGCTCTGCCTTGAATGTTCTGAGCCTAAATGGTAAAGAGTTATTGAATCGGACTAT
AACTATTGCTTTAAAAAGTCCAGACTGGATCAAAAATTTGGAAGAAGAAATGAGTTTAGAGAAAATTAGCATTGCATTGCCATCATCAACAAGCTCTACC
CTGCTTGGTGAAGATGCAGAGGTTGCAGCAGATTTTGATATGGAAGGTGATGTTGATGACTATAGTGCTGAAGTGGAGGAACTTCTTCCTCAGCATCTCC
AGCCATCTTCAAGTTCCGGCCTTGGTACTTCCCCCAGCTCTTCACCCCGAACTAGTCCCTGCCAGTCACCTACAATATCAGAGGGTCCTGTACCTTCCCT
TCCCATCAGACCAAGCCGAGCACCGTCAAGAACTCCTGGGCCTCCCAGTGCACAGAGTTCTCCTATTGACGCGCAGCCAGCAACGCCGCTGCCGCAGAAA
GACCCCGCCCAGCCCTTGGAGCCCAAGCGGCCGCCGCCGCCCCGCCCGGTCGCCCCTCCCACACGCCCGGCTCCCCCACAGAGACCTCCTCCGCCTTCAG
GGGCTAGGAGTCCTGCACCCACTAGAAAGGAATTTGGAGCACCCAAAAGCCCTGGAACAACAAGGAAAGATAATATAGGACGCAGTCAGCCTTCACCTCA
AGCAGGACTTGCAGGCCCAGGACCTGCTGGATACAGTACAGCCAGACCGACGATTCCTCCTCGTGCTGGAGTTATCAGTGCCCCACAGAGCCACGCGCGG
GCATCTGCTGGAAGACTGACTCCTGAAAGCCAAAGCAAAACATCAGAAACGTCGAAAGGTTCAACTTTCCTTCCTGAACCACTGAAGCCTCAGGCTGCTT
TTCCTCCGCAGTCTTCTTTGCCCCCGCCTGCTCAAAGGTTGCAAGAGCCTCTTGTCCCTGTGGCAGCACCTATGCCTCAGTCTGGCCCCCAGCCAAATTT
GGAAACCCCACCACAACCACCACCTCGAAGCAGGTCATCCCATAGCTTGCCTTCAGAAGCTTCCTCACAACCGCAACAGGAGCAACCATCAGGGTAACAG
GTAAAAACAAATGGAATCTCTGATGGCAAAAGAGAATCACCATTAAAGATTGACCCATTTGAAGATCTGTCATTTAATCTGCTTGCTGTATCAAAGGCTC
AGCTATCTGTTCAAACGTCACCTGTTCCCACCCCAGACCCAAAGAGGTTGATTCAGTTGCCTTCTGCAACGCAAAGTAATGTTTTGAGTTCTGTAAGTTG
CATGCCAACAATGCCTCCAATTCCAGCTCGGAGTCAATCCCAGGAAAATATGCGAAGTTCTCCAAACCCATTTATTACTGGCTTGACCAGGACAAATCCT
TTCAGTGACAGGACTGCTGCTCCTGGAAACCCATTTAGAGCCAAGTCTGAAGAATCAGAGGCAACTTCATGGTTCTCCAAAGAAGAGCCCGTTACTATCA
GTCCTTTCCCTTCTCTGCAGCCTCTTGGTCATAACAAAAGCAGGGCTTCATCTTCACTTGATGGCTTTAAGGACAGTTTTGATCTACAGGGCCAGTCTAC
ATTAAAAATTAGCAACCCGAAAGGATGGGTAACCTTCGAGGAAGAAGAGGATTTTGGTGTGAAAGGGAAGTCAAAGTCAGCTTGTTCAGACTTACTGGGT
AATCAGCCAAGTTCATTTTCTGGCTCCAACCTGACATTGAATGATGACTGGAATAAAGGTACAAATGTCTCCTTCTGTGTGTTGCCGTCAAGAAGACCTC
CTCCACCTCCTGTCCCTCTGCTCCCGCCCGGCACCAGCCCTCCAGTAGATCCTTTCACGACCTTGGCCTCTAAGGCTTCACCCACACTGGACTTTACAGA
AAGATAACGCCATGCAATAGAAAACAGTGGGTACTTGCTTTTGGCAGGATAGAGCTAAGAGAATTGGGCATTAGTATTTCATTATGTGCAATAAGTCATT
GTAAGTGCACTGATATCTTCACAAAACACCACTATTTGATGTGTACAGAGTTGGACTATGTGTATATTGGAAATAAGGAAAAACCCTTCTCATTGTTAAC
TGGAGTTTTGATGTATTTCTCTTTGGATGAATAGGAGACAGTAGTAGCCATAAAAAGTACTTATACTTTAGAAAACAGTCCTTATTCAGAAACTTTTCGG
TCAGTCTTCTGAAGAATCTCAAAAAGCCCACCCAACTTTCAGCTGACATTTCCACCAGCCCTCTCATACTTGTTAACAATTGGTATCTTTGAGTATTTAC
CAAAGAGCTGCCAAGGTTACAGTGAACAGAGTTTTGAAAGGCATTGCTTTAAAGGAAAAAAGTATAGGTATGTGTACATATATAATACATACAAACACAT
GTACTTCTGTATACATTTACATATTTTTACAATTCATACTTTAATTTCTAGGCTATAACTCAGACCAAATTATACCTAAAAGTTCCAACAAAGTCCCTTT
TTCAATATCACATTACCAAAAAGATGGCTGCAAATGTAATTTGGACCTTTCATTAATTTTGTTTTCAAAACTAGAATAATCTCACCACAGAATCAGAATT
TTCTACCGTTCCACACCCAACCCCTTCAAATACACACAACCTTGTTACTTTTCACTCCAGCACCTTCATACGCTTTTCTCCAGGAGGAGGTTCTTGCAGC
TGGAAACAGCCTATTTTGTGGTCACTGTCAAGTGGATGGATATTCTAGCGCTCCCAAAAAAGCACTATGGCCTTATATGCAGGGAAGGCACATACCACCA
AGTTCAATGAGAAATATTAGAGCTAACCGTACTCTCTTCTCTGCGTACGTTCGAGTATACGTTGCCCATATCCCTCCCATATTTTCTTTTTGCTGCTTTT
GCTCTGGAACTTTGCTTTTAGCAGGGAAAGCAGCTGTCCCCTGAGTGCTTTGAATTGGGAATATACCCAGTGTGTGTTCTCCCCCCTCTTACGAGGCTAC
ATAACACATCTATGATGCTGCTTTAAGTTTTTAGAGGCTATACCTCAAAGTAGCTGCGGATTTTGTCTCCTGCACTGCCAATATGCAACTGATCCCGCTT
TTATTAATTTTTTGAAGAAGTACACAGAATTTTTACAGAATGTAGTATTTTGATATCATTAAGTAAACCAATCAGAAAACTCCTTGAGCAATAGTTGTTT
CTTTGTCAGTTTCAGTTACAATCATCTTTACCCATTAAGACTTACATTAACATTCCTTTTATATAAAGAGTTGTATATGTCCACCTAAATTCCTATGTCC
ACACTTAACCTTTAAAGATGTACATTGAGGGAATATCAAAAAATAGCGTTCATGGCTACGAATATGTAGAATGTTAAAAGCACAGCAAACTGCACTGCAC
TTATAAAGCAAATCTATTAGAAAAAAAGCATTTTTCTAAATGCTCAAATGTTATCAAAATACTATATTTATAGAAGTAATCTTCTCTGTTAACAGCCAAG
ATTTGCTGTTAGAAATAACTCTTGTGAGTTTTATATTGTGCTTTTTGGAGGTTCTAATCATTTCAGCAGTAGCGTCTTAAACAGCAGTATTACTATAAGC
AGTTGCTTCAAAATGTGAATTAACTTGTTGAAACTGTGGCTTTAACATCCATGTGACTAGTGTATATGGTATTTGCTCTCCATTAGCAAAATAATTCATT
GTTAGGTAAACTTCACTAGTGCAAATTGCAGATCTGTGAGCAATGTTTCCTATTGAATATAAACTACTGTCTAAAATATACATATCAGCAGCCCAGCCTT
TATCAGGAAAATTATACTTGGCAAGTTGCTGAAAATGCACAAAGTTATGAAAGTTAAAGGTATGCTGCAAATAACTAGCCATTATTCTATGTATTATTAA
ATATTTACTAGTTCTGTTAAAAGCAGAGCAGAAGTTAGACACTAAGGATCTCTTTGTGAACTCTGTGTTCTCTATATTAGATTGCTGTTTATATGTAAGA
ATTTTATTGCTTATGTGGCATACAATATTTATAACTATAAACTTTATAGAAGTACAGTATTAAAGTCAGTGGTACACAGACATTCTGTACATATCCTGTG
AAACGTGCTGTCATATGAAATAAATATATCTGTCTTTAC
- refseq_SYNJ1.F2 (forward primer)
- refseq_SYNJ1.R2 (reverse primer)
- Single exon skipping
Frame 0
GSCCGQTHGQPGGRTPPRPVSASAASAGAGCLRRKENGVQ*RIPDLSQIGSPTFQPHSGN*A*GRMS
HVRVWGCRCALICRKRGNQGYILQSTGCIWTLR
CSAVKSW*YYVTLSGPSHWMYVCWKNSRI*SFP
SYFH*VYITANRFFR*GSHFRSAESFEFRKLLFC
MVCIWHQFRFES*CAS*HARTDN***IFLESVF
AFASQTLWREL**LVITSYVWRSRNQNNLCCS*
TGEGLPHFKIKL*TSWDQV*CPGNK**WSCCQFC
RNRTGCVLR*LSFFLHTNPRICSIVLGATRVAS
GISSCPYVKGI*SQCTCF*QAF*NT*ELIW*TN
NSKFAWI*GR*TYAK*SFPESFESF*TCC*YPDG
EF*LSSNG*GRKGRKIT*CS*TSSPEVSRLWIF
LFQWK*SSKMPEWYSSNKLLGLS**NK*CAGIS
WLRDAS*TVGSSWFS*KASVGDSLSRSFSVNVVR
EW*FNQ*DICRNWSS*RESEVKRWCSLCYPNNS
E*LL*QLQARGH*CFATGKYSE**FS*QSSSTF
NYWKFACF*ADITVSIF*STKEHV*EFLQIFKA*
ENSSMCRNLECEWWEAISQHSF*ESDTH*LAS*
CTQVSWHPGVSR*KK*AN*YICNWF*RNGRIEC
WKHCECKHNKSEALGCRTSEDNLQRQQVCAAGF*
TVGGRLFVCFYQTTACSFYQGCCS*YCEDWNGR
CNWK*GSSCNPNALPYNQPLLRL*PLCCRAVTS
QRKK*RFYRNSTKIEFSYGKDAIFP*LCILVW*F
QLSNRSP*RRS*RAHKTAKLGFSYSRRSTYQSE
KCWTGF*RIFRRKGNLCSDI*V*LVF*RL*HQ*
KVPHPCLDRPCPLEKEEMAF**IS*RSRSSKC*F
SR*KQNSVHVDSRHFAALWKS*AEDF*PQACRC
PD*YRYI*S*S*REAKHL*RSNCSSGSTRWYSI
GLNQKFFTRK*FF**CLD**ASAAVCKFW*SYTY
KICRR*NVGYIFGGKLCLECSEPKW*RVIESDY
NYCFKKSRLDQKFGRRNEFREN*HCIAIINKLY
PAW*RCRGCSRF*YGR*C**L*C*SGGTSSSASP
AIFKFRPWYFPQLFTPN*SLPVTYNIRGSCTFP
SHQTKPSTVKNSWASQCTEFSY*RAASNAAAAE
RPRPALGAQAAAAAPPGRPSHTPGSPTETSSAFR
G*ESCTH*KGIWSTQKPWNNKER*YRTQSAFTS
SRTCRPRTCWIQYSQTDDSSSCWSYQCPTEPRA
GICWKTDS*KPKQNIRNVERFNFPS*TTEASGCF
SSAVFFAPACSKVARASCPCGSTYASVWPPAKF
GNPTTTTTSKQVIP*LAFRSFLTTATGATIRVT
GKNKWNL*WQKRITIKD*PI*RSVI*SACCIKGS
AICSNVTCSHPRPKEVDSVAFCNAK*CFEFCKL
HANNASNSSSESIPGKYAKFSKPIYYWLDQDKS
FQ*QDCCSWKPI*SQV*RIRGNFMVLQRRARYYQ
SFPFSAASWS*QKQGFIFT*WL*GQF*STGPVY
IKN*QPERMGNLRGRRGFWCEREVKVSLFRLTG
*SAKFIFWLQPDIE**LE*RYKCLLLCVAVKKTS
STSCPSAPARHQPSSRSFHDLGL*GFTHTGLYR
KITPCNRKQWVLAFGRIELRELGISISLCAISH
CKCTDIFTKHHYLMCTELDYVYIGNKEKPFSLLT
GVLMYFSLDE*ETVVAIKSTYTLENSPYSETFR
SVF*RISKSPPNFQLTFPPALSYLLTIGIFEYL
PKSCQGYSEQSFERHCFKGKKYRYVYIYNTYKHM
YFCIHLHIFTIHTLISRL*LRPNYT*KFQQSPF
FNITLPKRWLQM*FGPFINFVFKTRIISPQNQN
FLPFHTQPLQIHTTLLLFTPAPSYAFLQEEVLAA
GNSLFCGHCQVDGYSSAPKKALWPYMQGRHIPP
SSMRNIRANRTLFSAYVRVYVAHIPPIFSFCCF
CSGTLLLAGKAAVP*VL*IGNIPSVCSPPSYEAT
*HIYDAALSF*RLYLKVAADFVSCTANMQLIPL
LLIF*RSTQNFYRM*YFDIIK*TNQKTP*AIVV
SLSVSVTIIFTH*DLH*HSFYIKSCICPPKFLCP
HLTFKDVH*GNIKK*RSWLRICRMLKAQQTALH
L*SKSIRKKAFF*MLKCYQNTIFIEVIFSVNSQ
DLLLEITLVSFILCFLEVLIISAVAS*TAVLL*A
VASKCELTC*NCGFNIHVTSVYGICSPLAK*FI
VR*TSLVQIADL*AMFPIEYKLLSKIYISAAQP
LSGKLYLASC*KCTKL*KLKVCCK*LAIILCIIK
YLLVLLKAEQKLDTKDLFVNSVFSILDCCLYVR
ILLLMWHTIFITINFIEVQY*SQWYTDILYISC
ETCCHMK*IYLSL
Frame 1
GAAAARPTGSRAGGRLQDQSLPPQRQRERAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEEC
LMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLG
VLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFR
VTSTEFISLRIDSSDEDRISEVRKVLNSGNFYF
AWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSL
HLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHK
QAKACLISRLSCERAGTRFNVRGTNDDGHVANF
VETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQV
GSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQI
IVNLLGSKEGEHMLSKAFQSHLKASEHAADIQM
VNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFF
YFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFL
GLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWS
VNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQ
NNFFDSSKQEAIDVLLLGNTLNSDLADKARALL
TTGSLRVSEQTLQSASSKVLKSMCENFYKYSKP
KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLD
APKLAGIQEFQDKRSKPTDIFAIGFEEMVELNA
GNIVSASTTNQKLWAVELQKTISRDNKYVLLAS
EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGG
ATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQV
KERNEDFIEIARKLSFPMGRMLFSHDYVFWCGD
FNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQK
NAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSE
KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS
FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVA
LIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVL
VSIKSSLPENNFFDDALIDELLQQFASFGEVIL
IRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTI
TIALKSPDWIKNLEEEMSLEKISIALPSSTSST
LLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL
QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSL
PIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK
DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS
GARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQ
AGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR
ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAA
FPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNL
ETPPQPPPRSRSSHSLPSEASSQPQQEQPSG*Q
VKTNGISDGKRESPLKIDPFEDLSFNLLAVSKA
QLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSC
MPTMPPIPARSQSQENMRSSPNPFITGLTRTNP
FSDRTAAPGNPFRAKSEESEATSWFSKEEPVTI
SPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQST
LKISNPKGWVTFEEEEDFGVKGKSKSACSDLLG
NQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRP
PPPPVPLLPPGTSPPVDPFTTLASKASPTLDFTE
R*RHAIENSGYLLLAG*S*ENWALVFHYVQ*VI
VSALISSQNTTI*CVQSWTMCILEIRKNPSHC*
LEF*CISLWMNRRQ**P*KVLIL*KTVLIQKLFG
QSSEESQKAHPTFS*HFHQPSHTC*QLVSLSIY
QRAAKVTVNRVLKGIALKEKSIGMCTYIIHTNT
CTSVYIYIFLQFIL*FLGYNSDQIIPKSSNKVPF
SISHYQKDGCKCNLDLSLILFSKLE*SHHRIRI
FYRSTPNPFKYTQPCYFSLQHLHTLFSRRRFLQ
LETAYFVVTVKWMDILALPKKHYGLICREGTYHQ
VQ*EILELTVLSSLRTFEYTLPISLPYFLFAAF
ALELCF*QGKQLSPECFELGIYPVCVLPPLTRL
HNTSMMLL*VFRGYTSK*LRILSPALPICN*SRF
Y*FFEEVHRIFTECSILISLSKPIRKLLEQ*LF
LCQFQLQSSLPIKTYINIPFI*RVVYVHLNSYV
HT*PLKMYIEGISKNSVHGYEYVEC*KHSKLHCT
YKANLLEKKHFSKCSNVIKILYL*K*SSLLTAK
ICC*K*LL*VLYCAFWRF*SFQQ*RLKQQYYYK
QLLQNVN*LVETVALTSM*LVYMVFALH*QNNSL
LGKLH*CKLQICEQCFLLNINYCLKYTYQQPSL
YQENYTWQVAENAQSYES*RYAANN*PLFYVLL
NIY*FC*KQSRS*TLRISL*TLCSLY*IAVYM*E
FYCLCGIQYL*L*TL*KYSIKVSGTQTFCTYPV
KRAVI*NKYICLY
Frame 2
ELLRPDPRAAGRADASKTSLCLRSVSGSGLPPKKGEWRSVKDSGSITNWIPHLSAS*WKLGIRKNV
SCSSLGLSLCSHLQKKRQSRVHTPKYWMHMDS*
VFCG*ILVILCYIIWS*SLDVCLLEKFKNLKFSE
LLPLSLYHCESILQMRIAFQKCGKF*IQETFIL
HGLHLASV*I*VLMRIVACKNRQLIIDFSGISL
CICISNTMA*IVMTGYYVLCVEE*KSEQFMLLIN
RRRLASFQD*AVNELGPGLMSGEQMMMVMLPIL
*KQNRLCT*MTQFLPSYKSEDLFHCSGSNQGCK
WDLIVSVCQGDLKPMHLLLTGILEHLRTYMVNK*
**ICLDLRKVNIC*VKLSRVI*KLLNMLLISRW
*ILTIIKWLREERQKNYIVFLNLKSRSF*IMDF
FISMEVKFKDARVVQFEQTAWIVLIEQIVCRHFL
A*RC*LNSWKLLV*LKSLSW*LAFKKFFGQCGP
*MVIQSVRYMQELELLKGKRS*KMVLALLPEQF
RITSLTAPSKRPLMFCYWEIL*IVI*LTKLEHF*
LLEVCVFLSRHYSQHLLKY*RACVRISTNIQSL
RKFEYVSEPGM*MVGSNFAA*LLRIRHSLTGFL
MHPS*LASRSFKIKEVSQLIYLQLVLKKW*N*ML
ETL*VQAQQIRSSGL*NFRRQSPETTSMCCWLL
NSWWASVCLFLSDHSMLLLSGMLQLIL*RLEWE
VQLEIREQLQSECSSIQPAFASSVATLLQGSHKS
KKEMKIL*K*HEN*VFLWEGCYFPMTMYFGVVI
STIESISLTKKLKSS*DSKIGILL*QEINLSIR
KMLDRFLEDF*KER*PLLRHISMTCFLTTMTPVK
SAAPLPGQTVSFGEGGNGLLIDQLKI*IF*MLV
FKMKAKFCTRGLQALCCTMEELS*RLLTTGLSL
P*LI*IYLKLKLKRGKTFIKK*LQFRVHQMVQYW
SQSKVLYQKIIFLMMP*LMSFCSSLQVLVKLYL
*DL*KIKCGLHFWREALP*MF*A*MVKSY*IGL
*LLL*KVQTGSKIWKKK*V*RKLALHCHHQQALP
CLVKMQRLQQILIWKVMLMTIVLKWRNFFLSIS
SHLQVPALVLPPALHPELVPASHLQYQRVLYLP
FPSDQAEHRQELLGLPVHRVLLLTRSQQRRCRRK
TPPSPWSPSGRRRPARSPLPHARLPHRDLLRLQ
GLGVLHPLERNLEHPKALEQQGKII*DAVSLHL
KQDLQAQDLLDTVQPDRRFLLVLELSVPHRATRG
HLLED*LLKAKAKHQKRRKVQLSFLNH*SLRLL
FLRSLLCPRLLKGCKSLLSLWQHLCLSLAPSQI
WKPHHNHHLEAGHPIACLQKLPHNRNRSNHQGNR
*KQMESLMAKENHH*RLTHLKICHLICLLYQRL
SYLFKRHLFPPQTQRG*FSCLLQRKVMF*VL*V
ACQQCLQFQLGVNPRKICEVLQTHLLLA*PGQIL
SVTGLLLLETHLEPSLKNQRQLHGSPKKSPLLS
VLSLLCSLLVITKAGLHLHLMALRTVLIYRASL
H*KLATRKDG*PSRKKRILV*KGSQSQLVQTYWV
ISQVHFLAPT*H*MMTGIKVQMSPSVCCRQEDL
LHLLSLCSRPAPALQ*ILSRPWPLRLHPHWTLQ
KDNAMQ*KTVGTCFWQDRAKRIGH*YFIMCNKSL
*VH*YLHKTPLFDVYRVGLCVYWK*GKTLLIVN
WSFDVFLFG*IGDSSSHKKYLYFRKQSLFRNFS
VSLLKNLKKPTQLSADISTSPLILVNNWYL*VFT
KELPRLQ*TEF*KALL*RKKV*VCVHI*YIQTH
VLLYTFTYFYNSYFNF*AITQTKLYLKVPTKSL
FQYHITKKMAANVIWTFH*FCFQN*NNLTTESEF
STVPHPTPSNTHNLVTFHSSTFIRFSPGGGSCS
WKQPILWSLSSGWIF*RSQKSTMALYAGKAHTT
KFNEKY*S*PYSLLCVRSSIRCPYPSHIFFLLLL
LWNFAFSRESSCPLSALNWEYTQCVFSPLLRGY
ITHL*CCFKFLEAIPQSSCGFCLLHCQYATDPA
FINFLKKYTEFLQNVVF*YH*VNQSENSLSNSCF
FVSFSYNHLYPLRLTLTFLLYKELYMST*IPMS
TLNL*RCTLREYQKIAFMATNM*NVKSTANCTA
LIKQIY*KKSIFLNAQMLSKYYIYRSNLLC*QPR
FAVRNNSCEFYIVLFGGSNHFSSSVLNSSITIS
SCFKM*INLLKLWL*HPCD*CIWYLLSISKIIH
C*VNFTSANCRSVSNVSY*I*TTV*NIHISSPAF
IRKIILGKLLKMHKVMKVKGMLQITSHYSMYY*
IFTSSVKSRAEVRH*GSLCELCVLYIRLLFICK
NFIAYVAYNIYNYKLYRSTVLKSVVHRHSVHIL*
NVLSYEINISVF
Sequence NM_003895
GAGGAGGAGCCGGAGGAAGAGGGCTGCCTCCGAAGAAAGGAGAATGGCGTTCAGTAAAGGATTCCGGATCTATCACAAATTGGATCCCCCACCTTTCAGCCTCATAGTGGAAACTAGGCATAAGGAAGAATGTCTCATGTTCGAGTCTGGGGCTGTCGCTGTGCTCTCATCTGCAGAAAAAGAGGCAATCAAGGGTACAT
ACTCCAAAGTACTGGATGCATATGGACTCTTAGGTGTTCTGCGGTTAAATCTTGGTGATACTATGTTACATTATCTGGTCCTAGTCACTGGATGTATGTC
TGTTGGAAAAATTCAAGAATCTGAAGTTTTCCGAGTTACTTCCACTGAGTTTATATCACTGCGAATCGATTCTTCAGATGAGGATCGCATTTCAGAAGTG
CGGAAAGTTTTGAATTCAGGAAACTTTTATTTTGCATGGTCTGCATCTGGCATCAGTTTAGATTTGAGTCTTAATGCGCATCGTAGCATGCAAGAACAGA
CAACTGATAATAGATTTTTCTGGAATCAGTCTTTGCATTTGCATCTCAAACACTATGGCGTGAATTGTGATGACTGGTTATTACGTCTTATGTGTGGAGG
AGTAGAAATCAGAACAATTTATGCTGCTCATAAACAGGCGAAGGCTTGCCTCATTTCAAGATTAAGCTGTGAACGAGCTGGGACCAGGTTTAATGTCCGG
GGAACAAATGATGATGGTCATGTTGCCAATTTTGTAGAAACAGAACAGGTTGTGTACTTAGATGACTCAGTTTCTTCCTTCATACAAATCCGAGGATCTG
TTCCATTGTTCTGGGAGCAACCAGGGTTGCAAGTGGGATCTCATCGTGTCCGTATGTCAAGGGGATTTGAAGCCAATGCACCTGCTTTTGACAGGCATTT
TAGAACACTTAAGAACTTATATGGTAAACAAATAATAGTAAATTTGCTTGGATCTAAGGAAGGTGAACATATGCTAAGTAAAGCTTTCCAGAGTCATTTG
AAAGCTTCTGAACATGCTGCTGATATCCAGATGGTGAATTTTGACTATCATCAAATGGTTAAGGGAGGAAAGGCAGAAAAATTACATAGTGTTCTTAAAC
CTCAAGTCCAGAAGTTTCTAGATTATGGATTTTTTTATTTCAATGGAAGTGAAGTTCAAAGATGCCAGAGTGGTACAGTTCGAACAAACTGCTTGGATTG
TCTTGATAGAACAAATAGTGTGCAGGCATTTCTTGGCTTAGAGATGCTAGCTAAACAGTTGGAAGCTCTTGGTTTAGCTGAAAAGCCTCAGTTGGTGACT
CGCTTTCAAGAAGTTTTTCGGTCAATGTGGTCCGTGAATGGTGATTCAATCAGTAAGATATATGCAGGAACTGGAGCTCTTGAAGGGAAAGCGAAGTTAA
AAGATGGTGCTCGCTCTGTTACCCGAACAATTCAGAATAACTTCTTTGACAGCTCCAAGCAAGAGGCCATTGATGTTTTGCTACTGGGAAATACTCTGAA
TAGTGATTTAGCTGACAAAGCTCGAGCACTTTTAACTACTGGAAGTTTGCGTGTTTCTGAGCAGACATTACAGTCAGCATCTTCTAAAGTACTAAAGAGC
ATGTGTGAGAATTTCTACAAATATTCAAAGCCTAAGAAAATTCGAGTATGTGTCGGAACCTGGAATGTGAATGGTGGGAAGCAATTTCGCAGCATAGCTT
TTAAGAATCAGACACTCACTGACTGGCTTCTTGATGCACCCAAGTTAGCTGGCATCCAGGAGTTTCAAGATAAAAGAAGTAAGCCAACTGATATATTTGC
AATTGGTTTTGAAGAAATGGTAGAATTGAATGCTGGAAACATTGTGAGTGCAAGCACAACAAATCAGAAGCTCTGGGCTGTAGAACTTCAGAAGACAATC
TCCAGAGACAACAAGTATGTGCTGCTGGCTTCTGAACAGTTGGTGGGCGTCTGTTTGTTTGTTTTTATCAGACCACAGCATGCTCCTTTTATCAGGGATG
TTGCAGTTGATACTGTGAAGACTGGAATGGGAGGTGCAACTGGAAATAAGGGAGCAGTTGCAATCCGAATGCTCTTCCATACAACCAGCCTTTGCTTCGT
CTGTAGCCACTTTGCTGCAGGGCAGTCACAAGTCAAAGAAAGAAATGAAGATTTTATAGAAATAGCACGAAAATTGAGTTTTCCTATGGGAAGGATGCTA
TTTTCCCATGACTATGTATTTTGGTGTGGTGATTTCAACTATCGAATCGATCTCCCTAACGAAGAAGTTAAAGAGCTCATAAGACAGCAAAATTGGGATT
CTCTTATAGCAGGAGATCAACTTATCAATCAGAAAAATGCTGGACAGGTTTTTAGAGGATTTTTAGAAGGAAAGGTAACCTTTGCTCCGACATATAAGTA
TGACTTGTTTTCTGACGACTATGACACCAGTGAAAAGTGCCGCACCCCTGCCTGGACAGACCGTGTCCTTTGGAGAAGGAGGAAATGGCCTTTTGATAGA
TCAGCTGAAGATCTAGATCTTCTAAATGCTAGTTTTCAAGATGAAAGCAAAATTCTGTACACGTGGACTCCAGGCACTTTGCTGCACTATGGAAGAGCTG
AGCTGAAGACTTCTGACCACAGGCCTGTCGTTGCCCTGATTGATATAGATATATTTGAAGTTGAAGCTGAAGAGAGGCAAAACATTTATAAAGAAGTAAT
TGCAGTTCAGGGTCCACCAGATGGTACAGTATTGGTCTCAATCAAAAGTTCTTTACCAGAAAATAATTTTTTTGATGATGCCTTGATTGATGAGCTTCTG
CAGCAGTTTGCAAGTTTTGGTGAAGTTATACTTATAAGATTTGTAGAAGATAAAATGTGGGTTACATTTTTGGAGGGAAGCTCTGCCTTGAATGTTCTGA
GCCTAAATGGTAAAGAGTTATTGAATCGGACTATAACTATTGCTTTAAAAAGTCCAGACTGGATCAAAAATTTGGAAGAAGAAATGAGTTTAGAGAAAAT
TAGCATTGCATTGCCATCATCAACAAGCTCTACCCTGCTTGGTGAAGATGCAGAGGTTGCAGCAGATTTTGATATGGAAGGTGATGTTGATGACTATAGT
GCTGAAGTGGAGGAACTTCTTCCTCAGCATCTCCAGCCATCTTCAAGTTCCGGCCTTGGTACTTCCCCCAGCTCTTCACCCCGAACTAGTCCCTGCCAGT
CACCTACAATATCAGAGGGTCCTGTACCTTCCCTTCCCATCAGACCAAGCCGAGCACCGTCAAGAACTCCTGGGCCTCCCAGTGCACAGAGTTCTCCTAT
TGACGCGCAGCCAGCAACGCCGCTGCCGCAGAAAGACCCCGCCCAGCCCTTGGAGCCCAAGCGGCCGCCGCCGCCCCGCCCGGTCGCCCCTCCCACACGC
CCGGCTCCCCCACAGAGACCTCCTCCGCCTTCAGGGGCTAGGAGTCCTGCACCCACTAGAAAGGAATTTGGAGGTATTGGAGCCCCTCCCAGTCCTGGGG
TAGCTAGGAGAGAGATGGAAGCACCCAAAAGCCCTGGAACAACAAGGAAAGATAATATAGGACGCAGTCAGCCTTCACCTCAAGCAGGACTTGCAGGCCC
AGGACCTGCTGGATACAGTACAGCCAGACCGACGATTCCTCCTCGTGCTGGAGTTATCAGTGCCCCACAGAGCCACGCGCGGGCATCTGCTGGAAGACTG
ACTCCTGAAAGCCAAAGCAAAACATCAGAAACGTCGAAAGGTTCAACTTTCCTTCCTGAACCACTGAAGCCTCAGGCTGCTTTTCCTCCGCAGTCTTCTT
TGCCCCCGCCTGCTCAAAGGTTGCAAGAGCCTCTTGTCCCTGTGGCAGCACCTATGCCTCAGTCTGGCCCCCAGCCAAATTTGGAAACCCCACCACAACC
ACCACCTCGAAGCAGGTCATCCCATAGCTTGCCTTCAGAAGCTTCCTCACAACCGCAAGTAAAAACAAATGGAATCTCTGATGGCAAAAGAGAATCACCA
TTAAAGATTGACCCATTTGAAGATCTGTCATTTAATCTGCTTGCTGTATCAAAGGCTCAGCTATCTGTTCAAACGTCACCTGTTCCCACCCCAGACCCAA
AGAGGTTGATTCAGTTGCCTTCTGCAACGCAAAGTAATGTTTTGAGTTCTGTAAGTTGCATGCCAACAATGCCTCCAATTCCAGCTCGGAGTCAATCCCA
GGAAAATATGCGAAGTTCTCCAAACCCATTTATTACTGGCTTGACCAGGACAAATCCTTTCAGTGACAGGACTGCTGCTCCTGGAAACCCATTTAGAGCC
AAGTCTGAAGAATCAGAGGCAACTTCATGGTTCTCCAAAGAAGAGCCCGTTACTATCAGTCCTTTCCCTTCTCTGCAGCCTCTTGGTCATAACAAAAGCA
GGGCTTCATCTTCACTTGATGGCTTTAAGGACAGTTTTGATCTACAGGGCCAGTCTACATTAAAAATTAGCAACCCGAAAGGATGGGTAACCTTCGAGGA
AGAAGAGGATTTTGGTGTGAAAGGGAAGTCAAAGTCAGCTTGTTCAGACTTACTGGGTAATCAGCCAAGTTCATTTTCTGGCTCCAACCTGACATTGAAT
GATGACTGGAATAAAGGTACAAATGTCTCCTTCTGTGTGTTGCCGTCAAGAAGACCTCCTCCACCTCCTGTCCCTCTGCTCCCGCCCGGCACCAGCCCTC
CAGTAGATCCTTTCACGACCTTGGCCTCTAAGGCTTCACCCACACTGGACTTTACAGAAAGATAACGCCATGCAATAGAAAACAGTGGGTACTTGCTTTT
GGCAGGATAGAGCTAAGAGAATTGGGCATTAGTATTTCATTATGTGCAATAAGTCATTGTAAGTGCACTGATATCTTCACAAAACACCACTATTTGATGT
GTACAGAGTTGGACTATGTGTATATTGGAAATAAGGAAAAACCCTTCTCATTGTTAACTGGAGTTTTGATGTATTTCTCTTTGGATGAATAGGAGACAGT
AGTAGCCATAAAAAGTACTTATACTTTAGAAAACAGTCCTTATTCAGAAACTTTTCGGTCAGTCTTCTGAAGAATCTCAAAAAGCCCACCCAACTTTCAG
CTGACATTTCCACCAGCCCTCTCATACTTGTTAACAATTGGTATCTTTGAGTATTTACCAAAGAGCTGCCAAGGTTACAGTGAACAGAGTTTTGAAAGGC
ATTGCTTTAAAGGAAAAAAGTATAGGTATGTGTACATATATAATACATACAAACACATGTACTTCTGTATACATTTACATATTTTTACAATTCATACTTT
AATTTCTAGGCTATAACTCAGACCAAATTATACCTAAAAGTTCCAACAAAGTCCCTTTTTCAATATCACATTACCAAAAAGATGGCTGCAAATGTAATTT
GGACCTTTCATTAATTTTGTTTTCAAAACTAGAATAATCTCACCACAGAATCAGAATTTTCTACCGTTCCACACCCAACCCCTTCAAATACACACAACCT
TGTTACTTTTCACTCCAGCACCTTCATACGCTTTTCTCCAGGAGGAGGTTCTTGCAGCTGGAAACAGCCTATTTTGTGGTCACTGTCAAGTGGATGGATA
TTCTAGCGCTCCCAAAAAAGCACTATGGCCTTATATGCAGGGAAGGCACATACCACCAAGTTCAATGAGAAATATTAGAGCTAACCGTACTCTCTTCTCT
GCGTACGTTCGAGTATACGTTGCCCATATCCCTCCCATATTTTCTTTTTGCTGCTTTTGCTCTGGAACTTTGCTTTTAGCAGGGAAAGCAGCTGTCCCCT
GAGTGCTTTGAATTGGGAATATACCCAGTGTGTGTTCTCCCCCCTCTTACGAGGCTACATAACACATCTATGATGCTGCTTTAAGTTTTTAGAGGCTATA
CCTCAAAGTAGCTGCGGATTTTGTCTCCTGCACTGCCAATATGCAACTGATCCCGCTTTTATTAATTTTTTGAAGAAGTACACAGAATTTTTACAGAATG
TAGTATTTTGATATCATTAAGTAAACCAATCAGAAAACTCCTTGAGCAATAGTTGTTTCTTTGTCAGTTTCAGTTACAATCATCTTTACCCATTAAGACT
TACATTAACATTCCTTTTATATAAAGAGTTGTATATGTCCACCTAAATTCCTATGTCCACACTTAACCTTTAAAGATGTACATTGAGGGAATATCAAAAA
ATAGCGTTCATGGCTACGAATATGTAGAATGTTAAAAGCACAGCAAACTGCACTGCACTTATAAAGCAAATCTATTAGAAAAAAAGCATTTTTCTAAATG
CTCAAATGTTATCAAAATACTATATTTATAGAAGTAATCTTCTCTGTTAACAGCCAAGATTTGCTGTTAGAAATAACTCTTGTGAGTTTTATATTGTGCT
TTTTGGAGGTTCTAATCATTTCAGCAGTAGCGTCTTAAACAGCAGTATTACTATAAGCAGTTGCTTCAAAATGTGAATTAACTTGTTGAAACTGTGGCTT
TAACATCCATGTGACTAGTGTATATGGTATTTGCTCTCCATTAGCAAAATAATTCATTGTTAGGTAAACTTCACTAGTGCAAATTGCAGATCTGTGAGCA
ATGTTTCCTATTGAATATAAACTACTGTCTAAAATATACATATCAGCAGCCCAGCCTTTATCAGGAAAATTATACTTGGCAAGTTGCTGAAAATGCACAA
AGTTATGAAAGTTAAAGGTATGCTGCAAATAACTAGCCATTATTCTATGTATTATTAAATATTTACTAGTTCTGTTAAAAGCAGAGCAGAAGTTAGACAC
TAAGGATCTCTTTGTGAACTCTGTGTTCTCTATATTAGATTGCTGTTTATATGTAAGAATTTTATTGCTTATGTGGCATACAATATTTATAACTATAAAC
TTTATAGAAGTACAGTATTAAAGTCAGTGGTACACAGACATTCTGTACATATCCTGTGAAACGTGCTGTCATATGAAATAAATATATCTGTCTTTAC
- refseq_SYNJ1.F2 (forward primer)
- refseq_SYNJ1.R2 (reverse primer)
- Single exon skipping
Frame 0
EEEPEEEGCLRRKENGVQ*RIPDLSQIGSPTFQPHSGN*A*GRMSHVRVWGCRCALICRKRGNQGYI
LQSTGCIWTLRCSAVKSW*YYVTLSGPSHWMYV
CWKNSRI*SFPSYFH*VYITANRFFR*GSHFRS
AESFEFRKLLFCMVCIWHQFRFES*CAS*HARTD
N***IFLESVFAFASQTLWREL**LVITSYVWR
SRNQNNLCCS*TGEGLPHFKIKL*TSWDQV*CP
GNK**WSCCQFCRNRTGCVLR*LSFFLHTNPRIC
SIVLGATRVASGISSCPYVKGI*SQCTCF*QAF
*NT*ELIW*TNNSKFAWI*GR*TYAK*SFPESF
ESF*TCC*YPDGEF*LSSNG*GRKGRKIT*CS*T
SSPEVSRLWIFLFQWK*SSKMPEWYSSNKLLGL
S**NK*CAGISWLRDAS*TVGSSWFS*KASVGD
SLSRSFSVNVVREW*FNQ*DICRNWSS*RESEVK
RWCSLCYPNNSE*LL*QLQARGH*CFATGKYSE
**FS*QSSSTFNYWKFACF*ADITVSIF*STKE
HV*EFLQIFKA*ENSSMCRNLECEWWEAISQHSF
*ESDTH*LAS*CTQVSWHPGVSR*KK*AN*YIC
NWF*RNGRIECWKHCECKHNKSEALGCRTSEDN
LQRQQVCAAGF*TVGGRLFVCFYQTTACSFYQGC
CS*YCEDWNGRCNWK*GSSCNPNALPYNQPLLR
L*PLCCRAVTSQRKK*RFYRNSTKIEFSYGKDA
IFP*LCILVW*FQLSNRSP*RRS*RAHKTAKLGF
SYSRRSTYQSEKCWTGF*RIFRRKGNLCSDI*V
*LVF*RL*HQ*KVPHPCLDRPCPLEKEEMAF**
IS*RSRSSKC*FSR*KQNSVHVDSRHFAALWKS*
AEDF*PQACRCPD*YRYI*S*S*REAKHL*RSN
CSSGSTRWYSIGLNQKFFTRK*FF**CLD**AS
AAVCKFW*SYTYKICRR*NVGYIFGGKLCLECSE
PKW*RVIESDYNYCFKKSRLDQKFGRRNEFREN
*HCIAIINKLYPAW*RCRGCSRF*YGR*C**L*
C*SGGTSSSASPAIFKFRPWYFPQLFTPN*SLPV
TYNIRGSCTFPSHQTKPSTVKNSWASQCTEFSY
*RAASNAAAAERPRPALGAQAAAAAPPGRPSHT
PGSPTETSSAFRG*ESCTH*KGIWRYWSPSQSWG
S*ERDGSTQKPWNNKER*YRTQSAFTSSRTCRP
RTCWIQYSQTDDSSSCWSYQCPTEPRAGICWKT
DS*KPKQNIRNVERFNFPS*TTEASGCFSSAVFF
APACSKVARASCPCGSTYASVWPPAKFGNPTTT
TTSKQVIP*LAFRSFLTTASKNKWNL*WQKRIT
IKD*PI*RSVI*SACCIKGSAICSNVTCSHPRPK
EVDSVAFCNAK*CFEFCKLHANNASNSSSESIP
GKYAKFSKPIYYWLDQDKSFQ*QDCCSWKPI*S
QV*RIRGNFMVLQRRARYYQSFPFSAASWS*QKQ
GFIFT*WL*GQF*STGPVYIKN*QPERMGNLRG
RRGFWCEREVKVSLFRLTG*SAKFIFWLQPDIE
**LE*RYKCLLLCVAVKKTSSTSCPSAPARHQPS
SRSFHDLGL*GFTHTGLYRKITPCNRKQWVLAF
GRIELRELGISISLCAISHCKCTDIFTKHHYLM
CTELDYVYIGNKEKPFSLLTGVLMYFSLDE*ETV
VAIKSTYTLENSPYSETFRSVF*RISKSPPNFQ
LTFPPALSYLLTIGIFEYLPKSCQGYSEQSFER
HCFKGKKYRYVYIYNTYKHMYFCIHLHIFTIHTL
ISRL*LRPNYT*KFQQSPFFNITLPKRWLQM*F
GPFINFVFKTRIISPQNQNFLPFHTQPLQIHTT
LLLFTPAPSYAFLQEEVLAAGNSLFCGHCQVDGY
SSAPKKALWPYMQGRHIPPSSMRNIRANRTLFS
AYVRVYVAHIPPIFSFCCFCSGTLLLAGKAAVP
*VL*IGNIPSVCSPPSYEAT*HIYDAALSF*RLY
LKVAADFVSCTANMQLIPLLLIF*RSTQNFYRM
*YFDIIK*TNQKTP*AIVVSLSVSVTIIFTH*D
LH*HSFYIKSCICPPKFLCPHLTFKDVH*GNIKK
*RSWLRICRMLKAQQTALHL*SKSIRKKAFF*M
LKCYQNTIFIEVIFSVNSQDLLLEITLVSFILC
FLEVLIISAVAS*TAVLL*AVASKCELTC*NCGF
NIHVTSVYGICSPLAK*FIVR*TSLVQIADL*A
MFPIEYKLLSKIYISAAQPLSGKLYLASC*KCT
KL*KLKVCCK*LAIILCIIKYLLVLLKAEQKLDT
KDLFVNSVFSILDCCLYVRILLLMWHTIFITIN
FIEVQY*SQWYTDILYISCETCCHMK*IYLSL
Frame 1
RRSRRKRAASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGT
YSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMS
VGKIQESEVFRVTSTEFISLRIDSSDEDRISEV
RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQ
TTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGG
VEIRTIYAAHKQAKACLISRLSCERAGTRFNVR
GTNDDGHVANFVETEQVVYLDDSVSSFIQIRGS
VPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHF
RTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHL
KASEHAADIQMVNFDYHQMVKGGKAEKLHSVLK
PQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDC
LDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVT
RFQEVFRSMWSVNGDSISKIYAGTGALEGKAKL
KDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLN
SDLADKARALLTTGSLRVSEQTLQSASSKVLKS
MCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIA
FKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFA
IGFEEMVELNAGNIVSASTTNQKLWAVELQKTI
SRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRD
VAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFV
CSHFAAGQSQVKERNEDFIEIARKLSFPMGRML
FSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWD
SLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKY
DLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDR
SAEDLDLLNASFQDESKILYTWTPGTLLHYGRA
ELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI
AVQGPPDGTVLVSIKSSLPENNFFDDALIDELL
QQFASFGEVILIRFVEDKMWVTFLEGSSALNVL
SLNGKELLNRTITIALKSPDWIKNLEEEMSLEKI
SIALPSSTSSTLLGEDAEVAADFDMEGDVDDYS
AEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQ
SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI
DAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTR
PAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPG
VARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGP
GPAGYSTARPTIPPRAGVISAPQSHARASAGRL
TPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS
LPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQP
PPRSRSSHSLPSEASSQPQVKTNGISDGKRESP
LKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDP
KRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQ
ENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRA
KSEESEATSWFSKEEPVTISPFPSLQPLGHNKS
RASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEE
EEDFGVKGKSKSACSDLLGNQPSSFSGSNLTLN
DDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSP
PVDPFTTLASKASPTLDFTER*RHAIENSGYLLL
AG*S*ENWALVFHYVQ*VIVSALISSQNTTI*C
VQSWTMCILEIRKNPSHC*LEF*CISLWMNRRQ
**P*KVLIL*KTVLIQKLFGQSSEESQKAHPTFS
*HFHQPSHTC*QLVSLSIYQRAAKVTVNRVLKG
IALKEKSIGMCTYIIHTNTCTSVYIYIFLQFIL
*FLGYNSDQIIPKSSNKVPFSISHYQKDGCKCNL
DLSLILFSKLE*SHHRIRIFYRSTPNPFKYTQP
CYFSLQHLHTLFSRRRFLQLETAYFVVTVKWMD
ILALPKKHYGLICREGTYHQVQ*EILELTVLSSL
RTFEYTLPISLPYFLFAAFALELCF*QGKQLSP
ECFELGIYPVCVLPPLTRLHNTSMMLL*VFRGY
TSK*LRILSPALPICN*SRFY*FFEEVHRIFTEC
SILISLSKPIRKLLEQ*LFLCQFQLQSSLPIKT
YINIPFI*RVVYVHLNSYVHT*PLKMYIEGISK
NSVHGYEYVEC*KHSKLHCTYKANLLEKKHFSKC
SNVIKILYL*K*SSLLTAKICC*K*LL*VLYCA
FWRF*SFQQ*RLKQQYYYKQLLQNVN*LVETVA
LTSM*LVYMVFALH*QNNSLLGKLH*CKLQICEQ
CFLLNINYCLKYTYQQPSLYQENYTWQVAENAQ
SYES*RYAANN*PLFYVLLNIY*FC*KQSRS*T
LRISL*TLCSLY*IAVYM*EFYCLCGIQYL*L*T
L*KYSIKVSGTQTFCTYPVKRAVI*NKYICLY
Frame 2
GGAGGRGLPPKKGEWRSVKDSGSITNWIPHLSAS*WKLGIRKNVSCSSLGLSLCSHLQKKRQSRVH
TPKYWMHMDS*VFCG*ILVILCYIIWS*SLDVC
LLEKFKNLKFSELLPLSLYHCESILQMRIAFQKC
GKF*IQETFILHGLHLASV*I*VLMRIVACKNR
QLIIDFSGISLCICISNTMA*IVMTGYYVLCVE
E*KSEQFMLLINRRRLASFQD*AVNELGPGLMSG
EQMMMVMLPIL*KQNRLCT*MTQFLPSYKSEDL
FHCSGSNQGCKWDLIVSVCQGDLKPMHLLLTGI
LEHLRTYMVNK***ICLDLRKVNIC*VKLSRVI*
KLLNMLLISRW*ILTIIKWLREERQKNYIVFLN
LKSRSF*IMDFFISMEVKFKDARVVQFEQTAWI
VLIEQIVCRHFLA*RC*LNSWKLLV*LKSLSW*L
AFKKFFGQCGP*MVIQSVRYMQELELLKGKRS*
KMVLALLPEQFRITSLTAPSKRPLMFCYWEIL*
IVI*LTKLEHF*LLEVCVFLSRHYSQHLLKY*RA
CVRISTNIQSLRKFEYVSEPGM*MVGSNFAA*L
LRIRHSLTGFLMHPS*LASRSFKIKEVSQLIYL
QLVLKKW*N*MLETL*VQAQQIRSSGL*NFRRQS
PETTSMCCWLLNSWWASVCLFLSDHSMLLLSGM
LQLIL*RLEWEVQLEIREQLQSECSSIQPAFAS
SVATLLQGSHKSKKEMKIL*K*HEN*VFLWEGCY
FPMTMYFGVVISTIESISLTKKLKSS*DSKIGI
LL*QEINLSIRKMLDRFLEDF*KER*PLLRHIS
MTCFLTTMTPVKSAAPLPGQTVSFGEGGNGLLID
QLKI*IF*MLVFKMKAKFCTRGLQALCCTMEEL
S*RLLTTGLSLP*LI*IYLKLKLKRGKTFIKK*
LQFRVHQMVQYWSQSKVLYQKIIFLMMP*LMSFC
SSLQVLVKLYL*DL*KIKCGLHFWREALP*MF*
A*MVKSY*IGL*LLL*KVQTGSKIWKKK*V*RK
LALHCHHQQALPCLVKMQRLQQILIWKVMLMTIV
LKWRNFFLSISSHLQVPALVLPPALHPELVPAS
HLQYQRVLYLPFPSDQAEHRQELLGLPVHRVLL
LTRSQQRRCRRKTPPSPWSPSGRRRPARSPLPHA
RLPHRDLLRLQGLGVLHPLERNLEVLEPLPVLG
*LGERWKHPKALEQQGKII*DAVSLHLKQDLQA
QDLLDTVQPDRRFLLVLELSVPHRATRGHLLED*
LLKAKAKHQKRRKVQLSFLNH*SLRLLFLRSLL
CPRLLKGCKSLLSLWQHLCLSLAPSQIWKPHHN
HHLEAGHPIACLQKLPHNRK*KQMESLMAKENHH
*RLTHLKICHLICLLYQRLSYLFKRHLFPPQTQ
RG*FSCLLQRKVMF*VL*VACQQCLQFQLGVNP
RKICEVLQTHLLLA*PGQILSVTGLLLLETHLEP
SLKNQRQLHGSPKKSPLLSVLSLLCSLLVITKA
GLHLHLMALRTVLIYRASLH*KLATRKDG*PSR
KKRILV*KGSQSQLVQTYWVISQVHFLAPT*H*M
MTGIKVQMSPSVCCRQEDLLHLLSLCSRPAPAL
Q*ILSRPWPLRLHPHWTLQKDNAMQ*KTVGTCF
WQDRAKRIGH*YFIMCNKSL*VH*YLHKTPLFDV
YRVGLCVYWK*GKTLLIVNWSFDVFLFG*IGDS
SSHKKYLYFRKQSLFRNFSVSLLKNLKKPTQLS
ADISTSPLILVNNWYL*VFTKELPRLQ*TEF*KA
LL*RKKV*VCVHI*YIQTHVLLYTFTYFYNSYF
NF*AITQTKLYLKVPTKSLFQYHITKKMAANVI
WTFH*FCFQN*NNLTTESEFSTVPHPTPSNTHNL
VTFHSSTFIRFSPGGGSCSWKQPILWSLSSGWI
F*RSQKSTMALYAGKAHTTKFNEKY*S*PYSLL
CVRSSIRCPYPSHIFFLLLLLWNFAFSRESSCPL
SALNWEYTQCVFSPLLRGYITHL*CCFKFLEAI
PQSSCGFCLLHCQYATDPAFINFLKKYTEFLQN
VVF*YH*VNQSENSLSNSCFFVSFSYNHLYPLRL
TLTFLLYKELYMST*IPMSTLNL*RCTLREYQK
IAFMATNM*NVKSTANCTALIKQIY*KKSIFLN
AQMLSKYYIYRSNLLC*QPRFAVRNNSCEFYIVL
FGGSNHFSSSVLNSSITISSCFKM*INLLKLWL
*HPCD*CIWYLLSISKIIHC*VNFTSANCRSVS
NVSY*I*TTV*NIHISSPAFIRKIILGKLLKMHK
VMKVKGMLQITSHYSMYY*IFTSSVKSRAEVRH
*GSLCELCVLYIRLLFICKNFIAYVAYNIYNYK
LYRSTVLKSVVHRHSVHIL*NVLSYEINISVF
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