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Sequences

Sequence NM_020847

TCAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGCAGGGATTTAGTGCAAGAAGAAGAACAGTTGATGGAAGAAAAGAAAAAGAA AAAAGACGACAAGAAAAAGAAGGAAGCTGCTCAAAAGAAGGCCACTGAACAAAAAATCAAAGTGCCAGAACAGATAAAGCCCAGTGTAAGCCAGCCTCAG CCTGCCAACTCTAATAACGGCACTTCCACAGCAACCAGCACTAATAATAATGCCAAGCGAGCTACAGCCAACAATCAGCAGCCACAGCAGCAGCAGCAAC AGCAGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGCCGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGGCCTTGCCTCGGTATCCTCG TGAAGTACCTCCACGATTTCGCCACCAGGAACACAAACAGCTTCTAAAGAGGGGTCAGCATTTTCCTGTTATAGCAGCAAACCTTGGATCTGCTGTTAAG GTGTTAAACAGCCAGTCAGAAAGCAGTGCTTTAACAAATCAACAGCCACAAAATAACGGAGAGGTGCAGAACAGCAAAAACCAGTCAGATATAAACCACA GTACTTCAGGATCCCATTATGAAAATTCCCAGCGGGGACCTGTGTCTTCTACAAGTGATTCTAGCACAAACTGTAAGAATGCTGTTGTAAGTGACTTGTC GGAAAAAGAAGCATGGCCCTCAGCCCCTGGCAGTGATCCGGAGTTGGCTTCAGAATGTATGGATGCTGATTCTGCCTCCAGTTCTGAATCAGAGAGAAAC ATCACTATCATGGCTTCAGGGAACACAGGTGGTGAAAAAGATGGCCTTCGGAATAGCACTGGACTTGGTTCCCAAAACAAGTTTGTAGTTGGTAGCAGCA GCAATAATGTGGGCCATGGAAGTAGTACTGGGCCATGGGGTTTTTCCCATGGAGCCATAATAAGCACATGTCAGGTCTCTGTGGATGCTCCTGAAAGCAA ATCTGAAAGTAGCAACAATAGAATGAATGCTTGGGGCACTGTAAGTTCTTCATCAAATGGAGGGTTAAATCCAAGCACTTTGAATTCAGCTAGCAACCAT GGTGCCTGGCCAGTATTAGAGAACAATGGACTTGCCCTAAAAGGGCCTGTAGGGAGTGGTAGTTCTGGCATTAATATTCAGTGCAGTACTATAGGCCAGA TGCCTAACAATCAGAGTATTAACTCTAAAGTGAGTGGTGGTTCTACCCATGGTACCTGGGGAAGCCTTCAGGAAACTTGTGAATCTGAAGTAAGTGGTAC ACAGAAGGTTTCATTCAGTGGTCAACCTCAAAATATTACCACTGAAATGACTGGACCAAATAACACTACTAACTTTATGACCTCTAGTTTACCAAACTCC GGTTCAGTGCAGAATAATGAGCTGCCTAGTAGTAACACAGGGGCCTGGCGTGTGAGCACAATGAATCATCCTCAGATGCAGGCTCCATCAGGTATGAATG GCACTTCCCTTTCTCACCTTAGCAATGGAGAGTCAAAAAGTGGAGGCTCTTATGGTACTACATGGGGTGCCTATGGTTCTAATTACTCTGGAGACAAATG TTCAGGCCCTAATGGCCAAGCTAATGGTGACACTGTGAATGCAACTCTAATGCAGCCTGGCGTAAATGGTCCTATGGGCACTAACTTTCAAGTTAACACA AACAAAGGAGGTGGTGTGTGGGAATCTGGTGCAGCAAACTCCCAGAGTACATCATGGGGAAGTGGAAATGGCGCAAATTCTGGAGGAAGTCGAAGAGGAT GGGGAACCCCTGCACAAAACACTGGCACTAATTTACCCAGCGTTGAGTGGAACAAACTGCCTAGCAATCAGCATTCCAATGATAGTGCAAATGGCAATGG TAAGACGTTTACAAATGGATGGAAATCTACTGAGGAAGAGGATCAGGGTTCTGCCACATCTCAGACAAATGAGCAAAGCAGTGTGTGGGCCAAAACAGGA GGTACAGTGGAGAGCGATGGTAGTACAGAAAGCACTGGACGCCTTGAGGAAAAAGGAACTGGGGAAAGTCAGAGTAGAGACAGAAGAAAAATTGATCAGC ACACATTACTCCAAAGCATTGTAAACAGAACTGACTTAGATCCACGTGTCCTGTCCAACTCTGGTTGGGGACAGACTCCTATTAAGCAGAATACTGCCTG GGATACAGAAACATCACCTAGAGGGGAACGAAAGACTGACAATGGGACAGAGGCCTGGGGAAGCTCTGCAACACAGACTTTTAACTCAGGGGCATGTATA GATAAGACTAGCCCTAATGGTAATGATACCTCATCTGTATCAGGGTGGGGCGATCCCAAACCTGCTCTGAGGTGGGGAGATTCCAAAGGCTCAAACTGCC AGGGGGGGTGGGAAGATGATTCTGCTGCTACAGGAATGGTCAAGAGCAATCAGTGGGGGAATTGCAAAGAGGAGAAGGCTGCATGGAATGACTCGCAAAA GAATAAACAGGGATGGGGTGATGGACAAAAATCAAGCCAAGGGTGGTCTGTTTCTGCCAGTGATAACTGGGGAGAAACTTCAAGGAATAACCATTGGGGT GAGGCCAATAAGAAATCCAGCTCAGGAGGTAGTGACAGTGACAGGTCCGTTTCCGGTTGGAACGAACTTGGTAAAACTAGTTCTTTCACTTGGGGAAACA ACATAAATCCAAATAATTCATCAGGATGGGATGAATCTTCTAAACCTACTCCTTCCCAGGGATGGGGAGACCCTCCAAAGTCTAATCAGTCTCTAGGTTG GGGAGATTCGTCAAAGCCAGTCAGCTCTCCAGACTGGAACAAGCAACAAGACATTGTTGGATCTTGGGGAATCCCACCAGCTACAGGCAAACCTCCTGGT ACAGGCTGGCTGGGGGGACCTATACCAGCCCCAGCAAAAGAAGAAGAACCCACAGGCTGGGAGGAACCATCCCCAGAATCTATACGTCGCAAAATGGAGA TTGATGATGGAACTTCAGCTTGGGGAGATCCAAGCAAATACAACTACAAAAATGTGAACATGTGGAACAAAAACGTCCCAAATGGCAACAGCCGTTCAGA CCAGCAAGCACAGGTACATCAGCTGCTAACGCCTGCAAGTGCCATCTCAAACAAAGAGGCAAGCAGTGGCTCTGGCTGGGGTGAGCCCTGGGGGGAGCCT TCTACTCCAGCCACAACTGTGGATAATGGTACTTCAGCATGGGGTAAGCCCATAGACAGTGGTCCCAGCTGGGGGGAACCCATTGCTGCGGCATCCAGCA CATCCACGTGGGGCTCCAGCTCTGTTGGTCCACAAGCATTAAGCAAATCTGGGCCAAAATCTATGCAAGATGGCTGGTGTGGTGATGATATGCCATTGCC TGGAAATCGCCCCACTGGCTGGGAAGAGGAAGAGGATGTGGAGATTGGAATGTGGAATAGTAATTCATCTCAAGAGCTTAACTCATCTTTAAATTGGCCA CCATATACAAAGAAAATGTCATCGAAGGGTCTGAGTGGCAAAAAAAGGAGAAGGGAAAGGGGAATGATGAAAGGTGGAAACAAACAAGAAGAAGCGTGGA TAAATCCATTTGTTAAACAGTTTTCAAACATCAGTTTTTCGAGAGACTCACCAGAGGAAAATGTACAAAGCAATAAGATGGACCTTTCTGGAGGAATGTT ACAAGACAAACGAATGGAGATAGATAAACATAGCCTAAATATTGGTGATTACAATCGAACGGTCGGGAAAGGCCCTGGTTCTCGGCCTCAGATTTCCAAA GAGTCTTCCATGGAGCGCAATCCTTATTTTGATAAGGATGGCATTGTAGCAGATGAATCCCAAAACATGCAGTTTATGTCCAGTCAAAGCATGAAGCTTC CCCCTTCAAATAGTGCACTACCTAACCAGGCCCTTGGCTCCATAGCAGGGCTGGGTATGCAAAACTTGAATTCTGTTAGACAGAATGGCAATCCCAGTAT GTTTGGTGTTGGAAACACAGCAGCACAACCCCGGGGCATGCAGCAGCCTCCAGCACAACCTCTTAGTTCATCTCAGCCTAATCTCCGTGCTCAAGTGCCT CCTCCATTACTCTCCCCTCAGGTTCCAGTTTCATTGCTGAAGTATGCACCAAACAACGGTGGCCTGAATCCACTCTTTGGCCCTCAACAGGTAGCCATGC TGAACCAGCTATCCCAGCTAAACCAGCTTTCTCAGATCTCCCAGTTACAGCGATTGTTAGCGCAGCAGCAAAGGGCGCAGAGTCAGAGAAGCGTGCCTTC TGGGAACCGGCCGCAGCAAGACCAGCAGGGTCGACCTCTTAGTGTGCAGCAGCAAATGATGCAACAATCTCGTCAACTTGATCCAAACCTGTTGGTGAAG CAGCAGACTCCACCATCTCAGCAGCAGCCACTCCATCAGCCAGCCATGAAGTCTTTCCTTGACAATGTCATGCCCCACACTACACCTGAGCTGCAAAAAG GGCCATCACCAATAAATGCTTTCAGCAACTTCCCTATAGGCTTGAACTCAAACTTGAATGTAAATATGGATATGAACAGTATTAAAGAGCCACAGTCAAG ACTAAGGAAGTGGACGACAGTGGACAGCATTTCTGTGAACACATCTTTGGATCAAAACTCCAGCAAACATGGTGCTATTTCAAGTGGTTTCAGGCTGGAA GAGTCTCCATTTGTTCCCTATGACTTTATGAACAGCAGTACTTCACCAGCCAGTCCTCCAGGTTCAATAGGAGATGGCTGGCCACGTGCCAAATCGCCTA ACGGCTCTAGCAGTGTTAATTGGCCACCAGAATTTCGTCCTGGTGAGCCATGGAAAGGTTATCCAAACATTGACCCTGAAACTGACCCTTACGTCACTCC TGGCAGTGTCATAAACAATCTTTCAATTAATACTGTGCGGGAAGTTGACCACCTCAGGGACAGGAACAGTGGGTCATCCTCATCCTTGAACACCACGCTG CCTTCAACTAGTGCCTGGTCATCCATTCGTGCCTCCAACTACAACGTTCCCCTCAGCAGTACAGCACAAAGCACTTCAGCCAGAAATAGTGATTCCAAAT TGACATGGTCTCCTGGTTCAGTTACAAACACCTCTCTGGCTCATGAGCTGTGGAAGGTCCCTTTGCCACCTAAAAACATCACTGCTCCGTCCCGCCCACC TCCGGGACTGACTGGTCAGAAGCCACCCTTGTCTACGTGGGATAATTCTCCCCTTCGTATAGGTGGAGGATGGGGAAATTCTGACGCCAGATATACCCCA GGTTCCAGCTGGGGTGAGAGCAGCTCAGGGAGAATAACAAATTGGCTTGTTCTAAAAAACCTTACACCTCAGATCGATGGCTCAACTCTGCGCACTCTGT GCATGCAGCACGGCCCGCTGATCACATTCCACCTGAACCTCCCTCACGGAAATGCTCTGGTCCGCTACAGTTCAAAAGAAGAGGTAGTGAAGGCACAAAA GTCTCTGCACATGTGTGTACTGGGGAACACTACTATTCTTGCTGAGTTTGCCAGTGAAGAGGAGATCAGTCGTTTCTTTGCACAAAGCCAGTCTCTGACC CCTTCTCCCGGCTGGCAGTCTCTCGGGTCCAGCCAGAGCCGGCTGGGCTCCCTCGACTGTTCCCACTCATTCTCCAGCCGGACCGATCTCAATCACTGGA ATGGTGCTGGGCTGTCGGGAACTAACTGTGGAGACCTTCACGGCACTTCACTCTGGGGGACCCCGCATTATTCCACAAGCCTGTGGGGTCCCCCAAGCAG CAGCGACCCCCGAGGAATTAGCAGCCCATCTCCCATTAACGCTTTTCTTTCTGTTGACCACCTGGGTGGGGGTGGAGAGTCCATGTAACAGTGTAGATGC AGACTCACCGACCGGGACCTCAGACGCGAGGGAAAGGAGCACTAAGTGGGGCTCGCCGCCTGCAGCCAGGGGCCGCCTGTGGGAACAGCTATTCTCTGCA CATTTTCCACTTTGTTTTCCCCAAAACATATCAGTTTGAATACTTGAATCATGCAGGCCAATATTATAATGTGAAAAGGTATCTACTCTATTTACACTCC CAAATAGCGCCATACATGCTAAACCGTAGAGAATGAGCTCGCTTGTGTCTATTCATCATGTTTAGCCTTTGGATTCTTTTTTTTTTTTTCCTTCTATTCC TCCCCAACCCCCCCCCCCGCCCCTTTTTTTCTCTCTTGCAAAACCATTTTTTGGGCTGATAACGTATGAGCTTTTCCCTTTGCACTGAATGATGTTCTCT CCGTCTCATCGGCAGTATGGGGGGCAGCTGTCCCAGTGTCAATGTTTACTCAAGGGTGTTCTTAGGAGGCGTGCGCTCTCTACTATGCCTTGATGTTGCC TACCTTATTGTGGTATCGTGGAGTTTAAAAGATCAAGTTAGGATGCTGACTTAGGATTATTAATGAAAGTGTTGCACCAGTTTTTTCATGTTGTAAAACT AAAGAATTTCGCTCTGCAGTTTGAAAAACTGTGGCCACAGCTGTGACTTGCAGCCCACCTGCCACCCAGGACGGGCCCTGCACTTTGAATAGGCTTTCCA TTTTGTTTTGGAGGTTCTCACTTTGAACCTTCTTGTTTACAGATTTTTTTGTTTGTTTTTTGAGAAAAAAAAATGTTTACTCTTCCATCATTTAAAAAAA ATGTAAAAGACAAAAAAAAAATGGAGGATGATTTAAAAGATGCTTTCTATCTCTGGGAAAAAGGAGCAGCATTTGGCCATGTTCTTTTGTTTTTCTATTC CTGTCCCAAATCAAAGAGCATGGTTCTCAGGAAAACCAGTTCCCCAGTTTAAAAAAAAAAAAAAAAATTCCTTGTAGTTTCTTAGAGGAAAAAAAGAAAA ACCCCAACTTTTAGCACTGATACTACATATTGCTCTGTTAAAGAATTTTCTCTGCC

refseq_TNRC6A.F1 (forward primer)
refseq_TNRC6A.R1 (reverse primer)
Single exon skipping

Frame 0

SENWKLKLPKT*KEILAGI*CKKKNS*WKKRKR KKTTRKRRKLLKRRPLNKKSKCQNR*SPV*ASLS LPTLITALPQQPALIIMPSELQPTISSHSSSSN SSSRSSSSHSSSHSRSRSSSSHSSSHRPCLGIL VKYLHDFATRNTNSF*RGVSIFLL*QQTLDLLLR C*TASQKAVL*QINSHKITERCRTAKTSQI*TT VLQDPIMKIPSGDLCLLQVILAQTVRMLL*VTC RKKKHGPQPLAVIRSWLQNVWMLILPPVLNQRET SLSWLQGTQVVKKMAFGIALDLVPKTSL*LVAA AIMWAMEVVLGHGVFPMEP**AHVRSLWMLLKA NLKVATIE*MLGAL*VLHQMEG*IQAL*IQLATM VPGQY*RTMDLP*KGL*GVVVLALIFSAVL*AR CLTIRVLTLK*VVVLPMVPGEAFRKLVNLK*VV HRRFHSVVNLKILPLK*LDQITLLTL*PLVYQTP VQCRIMSCLVVTQGPGV*AQ*IILRCRLHQV*M ALPFLTLAMESQKVEALMVLHGVPMVLITLETN VQALMAKLMVTL*MQL*CSLA*MVLWALTFKLTQ TKEVVCGNLVQQTPRVHHGEVEMAQILEEVEED GEPLHKTLALIYPALSGTNCLAISIPMIVQMAM VRRLQMDGNLLRKRIRVLPHLRQMSKAVCGPKQE VQWRAMVVQKALDALRKKELGKVRVETEEKLIS THYSKAL*TELT*IHVSCPTLVGDRLLLSRILP GIQKHHLEGNERLTMGQRPGEALQHRLLTQGHV* IRLALMVMIPHLYQGGAIPNLL*GGEIPKAQTA RGGGKMILLLQEWSRAISGGIAKRRRLHGMTRK RINRDGVMDKNQAKGGLFLPVITGEKLQGITIGV RPIRNPAQEVVTVTGPFPVGTNLVKLVLSLGET T*IQIIHQDGMNLLNLLLPRDGETLQSLISL*V GEIRQSQSALQTGTSNKTLLDLGESHQLQANLLV QAGWGDLYQPQQKKKNPQAGRNHPQNLYVAKWR LMMELQLGEIQANTTTKM*TCGTKTSQMATAVQ TSKHRYISC*RLQVPSQTKRQAVALAGVSPGGSL LLQPQLWIMVLQHGVSP*TVVPAGGNPLLRHPA HPRGAPALLVHKH*ANLGQNLCKMAGVVMICHC LEIAPLAGKRKRMWRLECGIVIHLKSLTHL*IGH HIQRKCHRRV*VAKKGEGKGE**KVETNKKKRG *IHLLNSFQTSVFRETHQRKMYKAIRWTFLEEC YKTNEWR*INIA*ILVITIERSGKALVLGLRFPK SLPWSAILILIRMAL*QMNPKTCSLCPVKA*SF PLQIVHYLTRPLAP*QGWVCKT*ILLDRMAIPV CLVLETQQHNPGACSSLQHNLLVHLSLISVLKCL LHYSPLRFQFHC*SMHQTTVA*IHSLALNR*PC *TSYPS*TSFLRSPSYSDC*RSSKGRRVREACL LGTGRSKTSRVDLLVCSSK*CNNLVNLIQTCW*S SRLHHLSSSHSISQP*SLSLTMSCPTLHLSCKK GHHQ*MLSATSL*A*TQT*M*IWI*TVLKSHSQ D*GSGRQWTAFL*THLWIKTPANMVLFQVVSGWK SLHLFPMTL*TAVLHQPVLQVQ*EMAGHVPNRL TALAVLIGHQNFVLVSHGKVIQTLTLKLTLTSL LAVS*TIFQLILCGKLTTSGTGTVGHPHP*TPRC LQLVPGHPFVPPTTTFPSAVQHKALQPEIVIPN *HGLLVQLQTPLWLMSCGRSLCHLKTSLLRPAH LRD*LVRSHPCLRGIILPFV*VEDGEILTPDIPQ VPAGVRAAQGE*QIGLF*KTLHLRSMAQLCALC ACSTAR*SHST*TSLTEMLWSATVQKKR**RHK SLCTCVYWGTLLFLLSLPVKRRSVVSLHKASL*P LLPAGSLSGPARAGWAPSTVPTHSPAGPISITG MVLGCRELTVETFTALHSGGPRIIPQACGVPQA AATPEELAAHLPLTLFFLLTTWVGVESPCNSVDA DSPTGTSDARERSTKWGSPPAARGRLWEQLFSA HFPLCFPQNISV*ILESCRPIL*CEKVSTLFTL PNSAIHAKP*RMSSLVSIHHV*PLDSFFFFPSIP PQPPPPPLFFSLAKPFFGLITYELFPLH*MMFS PSHRQYGGQLSQCQCLLKGVLRRRALSTMP*CC LPYCGIVEFKRSS*DADLGLLMKVLHQFFHVVKL KNFALQFEKLWPQL*LAAHLPPRTGPAL*IGFP FCFGGSHFEPSCLQIFLFVF*EKKMFTLPSFKK NVKDKKKMEDDLKDAFYLWEKGAAFGHVLLFFYS CPKSKSMVLRKTSSPV*KKKKKFLVVS*RKKRK TPTFSTDTTYCSVKEFSL

Frame 1

QRIGS*SYQRRRKKS*QGFSARRRTVDGRKEKE KRRQEKEGSCSKEGH*TKNQSARTDKAQCKPAS ACQL**RHFHSNQH***CQASYSQQSAATAAAAT AAAAAAAATAAATAAAAAAAATAAATGLASVSS *STSTISPPGTQTASKEGSAFSCYSSKPWICC* GVKQPVRKQCFNKSTATK*RRGAEQQKPVRYKPQ YFRIPL*KFPAGTCVFYK*F*HKL*ECCCK*LV GKRSMALSPWQ*SGVGFRMYGC*FCLQF*IREK HHYHGFREHRW*KRWPSE*HWTWFPKQVCSW*QQ Q*CGPWK*YWAMGFFPWSHNKHMSGLCGCS*KQ I*K*QQ*NECLGHCKFFIKWRVKSKHFEFS*QP WCLASIREQWTCPKRACREW*FWH*YSVQYYRPD A*QSEY*L*SEWWFYPWYLGKPSGNL*I*SKWY TEGFIQWSTSKYYH*NDWTK*HY*LYDL*FTKL RFSAE**AA***HRGLACEHNESSSDAGSIRYEW HFPFSP*QWRVKKWRLLWYYMGCLWF*LLWRQM FRP*WPS*W*HCECNSNAAWRKWSYGH*LSS*H KQRRWCVGIWCSKLPEYIMGKWKWRKFWRKSKRM GNPCTKHWH*FTQR*VEQTA*QSAFQ**CKWQW *DVYKWMEIY*GRGSGFCHISDK*AKQCVGQNR RYSGERW*YRKHWTP*GKRNWGKSE*RQKKN*SA HITPKHCKQN*LRSTCPVQLWLGTDSY*AEYCL GYRNIT*RGTKD*QWDRGLGKLCNTDF*LRGMY R*D*P*W**YLICIRVGRSQTCSEVGRFQRLKLP GGVGR*FCCYRNGQEQSVGELQRGEGCME*LAK E*TGMG*WTKIKPRVVCFCQ**LGRNFKE*PLG *GQ*EIQLRR**Q*QVRFRLERTW*N*FFHLGKQ HKSK*FIRMG*IF*TYSFPGMGRPSKV*SVSRL GRFVKASQLSRLEQATRHCWILGNPTSYRQTSW YRLAGGTYTSPSKRRRTHRLGGTIPRIYTSQNGD **WNFSLGRSKQIQLQKCEHVEQKRPKWQQPFR PASTGTSAANACKCHLKQRGKQWLWLG*ALGGA FYSSHNCG*WYFSMG*AHRQWSQLGGTHCCGIQH IHVGLQLCWSTSIKQIWAKIYARWLVW**YAIA WKSPHWLGRGRGCGDWNVE**FISRA*LIFKLA TIYKENVIEGSEWQKKEKGKGNDERWKQTRRSVD KSIC*TVFKHQFFERLTRGKCTKQ*DGPFWRNV TRQTNGDR*T*PKYW*LQSNGRERPWFSASDFQ RVFHGAQSLF**GWHCSR*IPKHAVYVQSKHEAS PFK*CTT*PGPWLHSRAGYAKLEFC*TEWQSQY VWCWKHSSTTPGHAAASSTTS*FISA*SPCSSA SSITLPSGSSFIAEVCTKQRWPESTLWPSTGSHA EPAIPAKPAFSDLPVTAIVSAAAKGAESEKRAF WEPAAARPAGSTS*CAAANDATISST*SKPVGE AADSTISAAATPSASHEVFP*QCHAPHYT*AAKR AITNKCFQQLPYRLELKLECKYGYEQY*RATVK TKEVDDSGQHFCEHIFGSKLQQTWCYFKWFQAG RVSICSL*LYEQQYFTSQSSRFNRRWLATCQIA* RL*QC*LATRISSW*AMERLSKH*P*N*PLRHS WQCHKQSFN*YCAGS*PPQGQEQWVILILEHHA AFN*CLVIHSCLQLQRSPQQYSTKHFSQK**FQI DMVSWFSYKHLSGS*AVEGPFAT*KHHCSVPPT SGTDWSEATLVYVG*FSPSYRWRMGKF*RQIYP RFQLG*EQLRENNKLACSKKPYTSDRWLNSAHSV HAARPADHIPPEPPSRKCSGPLQFKRRGSEGTK VSAHVCTGEHYYSC*VCQ*RGDQSFLCTKPVSD PFSRLAVSRVQPEPAGLPRLFPLILQPDRSQSLE WCWAVGN*LWRPSRHFTLGDPALFHKPVGSPKQ QRPPRN*QPISH*RFSFC*PPGWGWRVHVTV*M QTHRPGPQTRGKGALSGARRLQPGAACGNSYSLH IFHFVFPKTYQFEYLNHAGQYYNVKRYLLYLHS QIAPYMLNRRE*ARLCLFIMFSLWILFFFFLLF LPNPPPRPFFSLLQNHFLG**RMSFSLCTE*CSL RLIGSMGGSCPSVNVYSRVFLGGVRSLLCLDVA YLIVVSWSLKDQVRMLT*DY**KCCTSFFML*N *RISLCSLKNCGHSCDLQPTCHPGRALHFE*AFH FVLEVLTLNLLVYRFFCLFFEKKKCLLFHHLKK M*KTKKKWRMI*KMLSISGKKEQHLAMFFCFSI PVPNQRAWFSGKPVPQFKKKKKNSL*FLRGKKEK PQLLALILHIALLKNFLC

Frame 2

RELEAKATKDVERNLSRDLVQEEEQLMEEKKKK KDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQ PANSNNGTSTATSTNNNAKRATANNQQPQQQQQ QQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPR EVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVK VLNSQSESSALTNQQPQNNGEVQNSKNQSDINH STSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLS EKEAWPSAPGSDPELASECMDADSASSSESERN ITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSS SNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESK SESSNNRMNAWGTVSSSSNGGLNPSTLNSASNH GAWPVLENNGLALKGPVGSGSSGINIQCSTIGQ MPNNQSINSKVSGGSTHGTWGSLQETCESEVSGT QKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNS GSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMN GTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKC SGPNGQANGDTVNATLMQPGVNGPMGTNFQVNT NKGGGVWESGAANSQSTSWGSGNGANSGGSRRG WGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNG KTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTG GTVESDGSTESTGRLEEKGTGESQSRDRRKIDQ HTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAW DTETSPRGERKTDNGTEAWGSSATQTFNSGACI DKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNC QGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQK NKQGWGDGQKSSQGWSVSASDNWGETSRNNHWG EANKKSSSGGSDSDRSVSGWNELGKTSSFTWGN NINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGW GDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPG TGWLGGPIPAPAKEEEPTGWEEPSPESIRRKME IDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSD QQAQVHQLLTPASAISNKEASSGSGWGEPWGEP STPATTVDNGTSAWGKPIDSGPSWGEPIAAASS TSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLP GNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWP PYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAW INPFVKQFSNISFSRDSPEENVQSNKMDLSGGML QDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISK ESSMERNPYFDKDGIVADESQNMQFMSSQSMKL PPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSM FGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVP PPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAM LNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPS GNRPQQDQQGRPLSVQQQMMQQSRQLDPNLLVK QQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQK GPSPINAFSNFPIGLNSNLNVNMDMNSIKEPQSR LRKWTTVDSISVNTSLDQNSSKHGAISSGFRLE ESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSP NGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTP GSVINNLSINTVREVDHLRDRNSGSSSSLNTTL PSTSAWSSIRASNYNVPLSSTAQSTSARNSDSK LTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPP PGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTP GSSWGESSSGRITNWLVLKNLTPQIDGSTLRTL CMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQK SLHMCVLGNTTILAEFASEEEISRFFAQSQSLT PSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHW NGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSS SDPRGISSPSPINAFLSVDHLGGGGESM*QCRC RLTDRDLRREGKEH*VGLAACSQGPPVGTAILC TFSTLFSPKHISLNT*IMQANIIM*KGIYSIYTP K*RHTC*TVENELACVYSSCLAFGFFFFFSFYS SPTPPPAPFFLSCKTIFWADNV*AFPFALNDVL SVSSAVWGAAVPVSMFTQGCS*EACALYYALMLP TLLWYRGV*KIKLGC*LRIINESVAPVFSCCKT KEFRSAV*KTVATAVTCSPPATQDGPCTLNRLS ILFWRFSL*TFLFTDFFVCFLRKKNVYSSII*KK CKRQKKNGG*FKRCFLSLGKRSSIWPCSFVFLF LSQIKEHGSQENQFPSLKKKKKIPCSFLEEKKK NPNF*H*YYILLC*RIFSA

Sequence NM_014494

CAAACCTTGGATCTGCTGTTAAGGTGTTAAACAGCCAGTCAGAAAGCAGTGCTTTAACAAATCAACAGCCACAAAATAACGGAGAGGTGCAGAACAGCAA AAACCAGTCAGTGAATAAGTAGCAGATCCTGGACTCACATCAAGATCTGTCTGACTCCAAAGATATGCTTGTAACCACCATGCTGTGCTTTGGCAACATA CAGGATGTGATTGGTAATGAGGAAGAGGACACAAATATATAAACCACAGTACTTCAGGATCCCATTATGAAAATTCCCAGCGGGGACCTGTGTCTTCTAC AAGTGATTCTAGCACAAACTGTAAGAATGCTGTTGTAAGTGACTTGTCGGAAAAAGAAGCATGGCCCTCAGCCCCTGGCAGTGATCCGGAGTTGGCTTCA GAATGTATGGATGCTGATTCTGCCTCCAGTTCTGAATCAGAGAGAAACATCACTATCATGGCTTCAGGGAACACAGGTGGTGAAAAAGATGGCCTTCGGA ATAGCACTGGACTTGGTTCCCAAAACAAGTTTGTAGTTGGTAGCAGCAGCAATAATGTGGGCCATGGAAGTAGTACTGGGCCATGGGGTTTTTCCCATGG AGCCATAATAAGCACATGTCAGGTCTCTGTGGATGCTCCTGAAAGCAAATCTGAAAGTAGCAACAATAGAATGAATGCTTGGGGCACTGTAAGTTCTTCA TCAAATGGAGGGTTAAATCCAAGCACTTTGAATTCAGCTAGCAACCATGGTGCCTGGCCAGTATTAGAGAACAATGGACTTGCCCTAAAAGGGCCTGTAG GGAGTGGTAGTTCTGGCATTAATATTCAGTGCAGTACTATAGGCCAGATGCCTAACAATCAGAGTATTAACTCTAAAGTGAGTGGTGGTTCTACCCATGG TACCTGGGGAAGCCTTCAGGAAACTTGTGAATCTGAAGTAAGTGGTACACAGAAGGTTTCATTCAGTGGTCAACCTCAAAATATTACCACTGAAATGACT GGACCAAATAACACTACTAACTTTATGACCTCTAGTTTACCAAACTCCGGTTCAGTGCAGAATAATGAGCTGCCTAGTAGTAACACAGGGGCCTGGCGTG TGAGCACAATGAATCATCCTCAGATGCAGGCTCCATCAGGTATGAATGGCACTTCCCTTTCTCACCTTAGCAATGGAGAGTCAAAAAGTGGAGGCTCTTA TGGTACTACATGGGGTGCCTATGGTTCTAATTACTCTGGAGACAAATGTTCAGGCCCTAATGGCCAAGCTAATGGTGACACTGTGAATGCAACTCTAATG CAGCCTGGCGTAAATGGTCCTATGGGCACTAACTTTCAAGTTAACACAAACAAAGGAGGTGGTGTGTGGGAATCTGGTGCAGCAAACTCCCAGAGTACAT CATGGGGAAGTGGAAATGGCGCAAATTCTGGAGGAAGTCGAAGAGGATGGGGAACCCCTGCACAAAACACTGGCACTAATTTACCCAGCGTTGAGTGGAA CAAACTGCCTAGCAATCAGCATTCCAATGATAGTGCAAATGGCAATGGTAAGACGTTTACAAATGGATGGAAATCTACTGAGGAAGAGGATCAGGGTTCT GCCACATCTCAGACAAATGAGCAAAGCAGTGTGTGGGCCAAAACAGGAGGTACAGTGGAGAGCGATGGTAGTACAGAAAGCACTGGACGCCTTGAGGAAA AAGGAACTGGGGAAAGTCAGAGTAGAGACAGAAGAAAAATTGATCAGCACACATTACTCCAAAGCATTGTAAACAGAACTGACTTAGATCCACGTGTCCT GTCCAACTCTGGTTGGGGACAGACTCCTATTAAGCAGAATACTGCCTGGGATACAGAAACATCACCTAGAGGGGAACGAAAGACTGACAATGGGACAGAG GCCTGGGGAAGCTCTGCAACACAGACTTTTAACTCAGGGGCATGTATAGATAAGACTAGCCCTAATGGTAATGATACCTCATCTGTATCAGGGTGGGGCG ATCCCAAACCTGCTCTGAGGTGGGGAGATTCCAAAGGCTCAAACTGCCAGGGGGGGTGGGAAGATGATTCTGCTGCTACAGGAATGGTCAAGAGCAATCA GTGGGGGAATTGCAAAGAGGAGAAGGCTGCATGGAATGACTCGCAAAAGAATAAACAGGGATGGGGTGATGGACAAAAATCAAGCCAAGGGTGGTCTGTT TCTGCCAGTGATAACTGGGGAGAAACTTCAAGGAATAACCATTGGGGTGAGGCCAATAAGAAATCCAGCTCAGGAGGTAGTGACAGTGACAGGTCCGTTT CCGGTTGGAACGAACTTGGTAAAACTAGTTCTTTCACTTGGGGAAACAACATAAATCCAAATAATTCATCAGGATGGGATGAATCTTCTAAACCTACTCC TTCCCAGGGATGGGGAGACCCTCCAAAGTCTAATCAGTCTCTAGGTTGGGGAGATTCGTCAAAGCCAGTCAGCTCTCCAGACTGGAACAAGCAACAAGAC ATTGTTGGATCTTGGGGAATCCCACCAGCTACAGGCAAACCTCCTGGTACAGGCTGGCTGGGGGGACCTATACCAGCCCCAGCAAAAGAAGAAGAACCCA CAGGCTGGGAGGAACCATCCCCAGAATCTATACGTCGCAAAATGGAGATTGATGATGGAACTTCAGCTTGGGGAGATCCAAGCAAATACAACTACAAAAA TGTGAACATGTGGAACAAAAACGTCCCAAATGGCAACAGCCGTTCAGACCAGCAAGCACAGGTACATCAGCTGCTAACGCCTGCAAGTGCCATCTCAAAC AAAGAGGCAAGCAGTGGCTCTGGCTGGGGTGAGCCCTGGGGGGAGCCTTCTACTCCAGCCACAACTGTGGATAATGGTACTTCAGCATGGGGTAAGCCCA TAGACAGTGGTCCCAGCTGGGGGGAACCCATTGCTGCGGCATCCAGCACATCCACGTGGGGCTCCAGCTCTGTTGGTCCACAAGCATTAAGCAAATCTGG GCCAAAATCTATGCAAGATGGCTGGTGTGGTGATGATATGCCATTGCCTGGAAATCGCCCCACTGGCTGGGAAGAGGAAGAGGATGTGGAGATTGGAATG TGGAATAGTAATTCATCTCAAGAGCTTAACTCATCTTTAAATTGGCCACCATATACAAAGAAAATGTCATCGAAGGGTCTGAGTGGCAAAAAAAGGAGAA GGGAAAGGGGAATGATGAAAGGTGGAAACAAACAAGAAGAAGCGTGGATAAATCCATTTGTTAAACAGTTTTCAAACATCAGTTTTTCGAGAGACTCACC AGAGGAAAATGTACAAAGCAATAAGATGGACCTTTCTGGAGGAATGTTACAAGACAAACGAATGGAGATAGATAAACATAGCCTAAATATTGGTGATTAC AATCGAACGGTCGGGAAAGGCCCTGGTTCTCGGCCTCAGATTTCCAAAGAGTCTTCCATGGAGCGCAATCCTTATTTTGATAAGGATGGCATTGTAGCAG ATGAATCCCAAAACATGCAGTTTATGTCCAGTCAAAGCATGAAGCTTCCCCCTTCAAATAGTGCACTACCTAACCAGGCCCTTGGCTCCATAGCAGGGCT GGGTATGCAAAACTTGAATTCTGTTAGACAGAATGGCAATCCCAGTATGTTTGGTGTTGGAAACACAGCAGCACAACCCCGGGGCATGCAGCAGCCTCCA GCACAACCTCTTAGTTCATCTCAGCCTAATCTCCGTGCTCAAGTGCCTCCTCCATTACTCTCCCCTCAGGTTCCAGTTTCATTGCTGAAGTATGCACCAA ACAACGGTGGCCTGAATCCACTCTTTGGCCCTCAACAGGTAGCCATGCTGAACCAGCTATCCCAGCTAAACCAGCTTTCTCAGATCTCCCAGTTACAGCG ATTGTTAGCGCAGCAGCAAAGGGCGCAGAGTCAGAGAAGCGTGCCTTCTGGGAACCGGCCGCAGCAAGACCAGCAGGGTCGACCTCTTAGTGTGCAGCAG CAAATGATGCAACAATCTCGTCAACTTGATCCAAACCTGTTGGTGAAGCAGCAGACTCCACCATCTCAGCAGCAGCCACTCCATCAGCCAGCCATGAAGT CTTTCCTTGACAATGTCATGCCCCACACTACACCTGAGCTGCAAAAAGGGCCATCACCAATAAATGCTTTCAGCAACTTCCCTATAGGCTTGAACTCAAA CTTGAATGTAAATATGGATATGAACAGTATTAAAGAGCCACAGTCAAGACTAAGGAAGTGGACGACAGTGGACAGCATTTCTGTGAACACATCTTTGGAT CAAAACTCCAGCAAACATGGTGCTATTTCAAGTGGTTTCAGGCTGGAAGAGTCTCCATTTGTTCCCTATGACTTTATGAACAGCAGTACTTCACCAGCCA GTCCTCCAGGTTCAATAGGAGATGGCTGGCCACGTGCCAAATCGCCTAACGGCTCTAGCAGTGTTAATTGGCCACCAGAATTTCGTCCTGGTGAGCCATG GAAAGGTTATCCAAACATTGACCCTGAAACTGACCCTTACGTCACTCCTGGCAGTGTCATAAACAATCTTTCAATTAATACTGTGCGGGAAGTTGACCAC CTCAGGGACAGGAACAGTGGGTCATCCTCATCCTTGAACACCACGCTGCCTTCAACTAGTGCCTGGTCATCCATTCGTGCCTCCAACTACAACGTTCCCC TCAGCAGTACAGCACAAAGCACTTCAGCCAGAAATAGTGATTCCAAATTGACATGGTCTCCTGGTTCAGTTACAAACACCTCTCTGGCTCATGAGCTGTG GAAGGTCCCTTTGCCACCTAAAAACATCACTGCTCCGTCCCGCCCACCTCCGGGACTGACTGGTCAGAAGCCACCCTTGTCTACGTGGGATAATTCTCCC CTTCGTATAGGTGGAGGATGGGGAAATTCTGACGCCAGATATACCCCAGGTTCCAGCTGGGGTGAGAGCAGCTCAGGGAGAATAACAAATTGGCTTGTTC TAAAAAACCTTACACCTCAGATCGATGGCTCAACTCTGCGCACTCTGTGCATGCAGCACGGCCCGCTGATCACATTCCACCTGAACCTCCCTCACGGAAA TGCTCTGGTCCGCTACAGTTCAAAAGAAGAGGTAGTGAAGGCACAAAAGTCTCTGCACATGTGTGTACTGGGGAACACTACTATTCTTGCTGAGTTTGCC AGTGAAGAGGAGATCAGTCGTTTCTTTGCACAAAGCCAGTCTCTGACCCCTTCTCCCGGCTGGCAGTCTCTCGGGTCCAGCCAGAGCCGGCTGGGCTCCC TCGACTGTTCCCACTCATTCTCCAGCCGGACCGATCTCAATCACTGGAATGGTGCTGGGCTGTCGGGAACTAACTGTGGAGACCTTCACGGCACTTCACT CTGGGGGACCCCGCATTATTCCACAAGCCTGTGGGGTCCCCCAAGCAGCAGCGACCCCCGAGGAATTAGCAGCCCATCTCCCATTAACGCTTTTCTTTCT GTTGACCACCTGGGTGGGGGTGGAGAGTCCATGTAACAGTGTAGATGCAGACTCACCGACCGGGACCTCAGACGCGAGGGAAAGGAGCACTAAGTGGGGC TCGCCGCCTGCAGCCAGGGGCCGCCTGTGGGAACAGCTATTCTCTGCACATTTTCCACTTTGTTTTCCCCAAAACATATCAGTTTGAATACTTGAATCAT GCAGGCCAATATTATAATGTGAAAAGGTATCTACTCTATTTACACTCCCAAATAGCGCCATACATGCTAAACCGTAGAGAATGAGCTCGCTTGTGTCTAT TCATCATGTTTAGCCTTTGGATTCTTTTTTTTTTTTTCCTTCTATTCCTCCCCAACCCCCCCCCCCGCCCCTTTTTTTCTCTCTTGCAAAACCATTTTTT GGGCTGATAACGTATGAGCTTTTCCCTTTGCACTGAATGATGTTCTCTCCGTCTCATCGGCAGTATGGGGGGCAGCTGTCCCAGTGTCAATGTTTACTCA AGGGTGTTCTTAGGAGGCGTGCGCTCTCTACTATGCCTTGATGTTGCCTACCTTATTGTGGTATCGTGGAGTTTAAAAGATCAAGTTAGGATGCTGACTT AGGATTATTAATGAAAGTGTTGCACCAGTTTTTTCATGTTGTAAAACTAAAGAATTTCGCTCTGCAGTTTGAAAAACTGTGGCCACAGCTGTGACTTGCA GCCCACCTGCCACCCAGGACGGGCCCTGCACTTTGAATAGGCTTTCCATTTTGTTTTGGAGGTTCTCACTTTGAACCTTCTTGTTTACAGATTTTTTTGT TTGTTTTTTGAGAAAAAAAAATGTTTACTCTTCCATCATTTAAAAAAAATGTAAAAGACAAAAAAAAAATGGAGGATGATTTAAAAGATGCTTTCTATCT CTGGGAAAAAGGAGCAGCATTTGGCCATGTTCTTTTGTTTTTCTATTCCTGTCCCAAATCAAAGAGCATGGTTCTCAGGAAAACCAGTTCCCCAGTTTAA AAAAAAAAAAAAAAATTCCTTGTAGTTTCTTAGAGGAAAAAAAGAAAAACCCCAACTTTTAGCACTGATACTACATATTGCTCTGTTAAAGAATTTTCTC TGCC

refseq_TNRC6A.F1 (forward primer)
refseq_TNRC6A.R1 (reverse primer)
Single exon skipping

Frame 0

QTLDLLLRC*TASQKAVL*QINSHKITERCRTA KTSQ*ISSRSWTHIKICLTPKICL*PPCCALATY RM*LVMRKRTQIYKPQYFRIPL*KFPAGTCVFY K*F*HKL*ECCCK*LVGKRSMALSPWQ*SGVGF RMYGC*FCLQF*IREKHHYHGFREHRW*KRWPSE *HWTWFPKQVCSW*QQQ*CGPWK*YWAMGFFPW SHNKHMSGLCGCS*KQI*K*QQ*NECLGHCKFF IKWRVKSKHFEFS*QPWCLASIREQWTCPKRACR EW*FWH*YSVQYYRPDA*QSEY*L*SEWWFYPW YLGKPSGNL*I*SKWYTEGFIQWSTSKYYH*ND WTK*HY*LYDL*FTKLRFSAE**AA***HRGLAC EHNESSSDAGSIRYEWHFPFSP*QWRVKKWRLL WYYMGCLWF*LLWRQMFRP*WPS*W*HCECNSN AAWRKWSYGH*LSS*HKQRRWCVGIWCSKLPEYI MGKWKWRKFWRKSKRMGNPCTKHWH*FTQR*VE QTA*QSAFQ**CKWQW*DVYKWMEIY*GRGSGF CHISDK*AKQCVGQNRRYSGERW*YRKHWTP*GK RNWGKSE*RQKKN*SAHITPKHCKQN*LRSTCP VQLWLGTDSY*AEYCLGYRNIT*RGTKD*QWDR GLGKLCNTDF*LRGMYR*D*P*W**YLICIRVGR SQTCSEVGRFQRLKLPGGVGR*FCCYRNGQEQS VGELQRGEGCME*LAKE*TGMG*WTKIKPRVVC FCQ**LGRNFKE*PLG*GQ*EIQLRR**Q*QVRF RLERTW*N*FFHLGKQHKSK*FIRMG*IF*TYS FPGMGRPSKV*SVSRLGRFVKASQLSRLEQATR HCWILGNPTSYRQTSWYRLAGGTYTSPSKRRRTH RLGGTIPRIYTSQNGD**WNFSLGRSKQIQLQK CEHVEQKRPKWQQPFRPASTGTSAANACKCHLK QRGKQWLWLG*ALGGAFYSSHNCG*WYFSMG*AH RQWSQLGGTHCCGIQHIHVGLQLCWSTSIKQIW AKIYARWLVW**YAIAWKSPHWLGRGRGCGDWN VE**FISRA*LIFKLATIYKENVIEGSEWQKKEK GKGNDERWKQTRRSVDKSIC*TVFKHQFFERLT RGKCTKQ*DGPFWRNVTRQTNGDR*T*PKYW*L QSNGRERPWFSASDFQRVFHGAQSLF**GWHCSR *IPKHAVYVQSKHEASPFK*CTT*PGPWLHSRA GYAKLEFC*TEWQSQYVWCWKHSSTTPGHAAAS STTS*FISA*SPCSSASSITLPSGSSFIAEVCTK QRWPESTLWPSTGSHAEPAIPAKPAFSDLPVTA IVSAAAKGAESEKRAFWEPAAARPAGSTS*CAA ANDATISST*SKPVGEAADSTISAAATPSASHEV FP*QCHAPHYT*AAKRAITNKCFQQLPYRLELK LECKYGYEQY*RATVKTKEVDDSGQHFCEHIFG SKLQQTWCYFKWFQAGRVSICSL*LYEQQYFTSQ SSRFNRRWLATCQIA*RL*QC*LATRISSW*AM ERLSKH*P*N*PLRHSWQCHKQSFN*YCAGS*P PQGQEQWVILILEHHAAFN*CLVIHSCLQLQRSP QQYSTKHFSQK**FQIDMVSWFSYKHLSGS*AV EGPFAT*KHHCSVPPTSGTDWSEATLVYVG*FS PSYRWRMGKF*RQIYPRFQLG*EQLRENNKLACS KKPYTSDRWLNSAHSVHAARPADHIPPEPPSRK CSGPLQFKRRGSEGTKVSAHVCTGEHYYSC*VC Q*RGDQSFLCTKPVSDPFSRLAVSRVQPEPAGLP RLFPLILQPDRSQSLEWCWAVGN*LWRPSRHFT LGDPALFHKPVGSPKQQRPPRN*QPISH*RFSF C*PPGWGWRVHVTV*MQTHRPGPQTRGKGALSGA RRLQPGAACGNSYSLHIFHFVFPKTYQFEYLNH AGQYYNVKRYLLYLHSQIAPYMLNRRE*ARLCL FIMFSLWILFFFFLLFLPNPPPRPFFSLLQNHFL G**RMSFSLCTE*CSLRLIGSMGGSCPSVNVYS RVFLGGVRSLLCLDVAYLIVVSWSLKDQVRMLT *DY**KCCTSFFML*N*RISLCSLKNCGHSCDLQ PTCHPGRALHFE*AFHFVLEVLTLNLLVYRFFC LFFEKKKCLLFHHLKKM*KTKKKWRMI*KMLSI SGKKEQHLAMFFCFSIPVPNQRAWFSGKPVPQFK KKKKNSL*FLRGKKEKPQLLALILHIALLKNFL C

Frame 1

KPWICC*GVKQPVRKQCFNKSTATK*RRGAEQQ KPVSE*VADPGLTSRSV*LQRYACNHHAVLWQH TGCDW**GRGHKYINHSTSGSHYENSQRGPVSST SDSSTNCKNAVVSDLSEKEAWPSAPGSDPELAS ECMDADSASSSESERNITIMASGNTGGEKDGLR NSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHG AIISTCQVSVDAPESKSESSNNRMNAWGTVSSS SNGGLNPSTLNSASNHGAWPVLENNGLALKGPV GSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHG TWGSLQETCESEVSGTQKVSFSGQPQNITTEMT GPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWR VSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSY GTTWGAYGSNYSGDKCSGPNGQANGDTVNATLM QPGVNGPMGTNFQVNTNKGGGVWESGAANSQST SWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWN KLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGS ATSQTNEQSSVWAKTGGTVESDGSTESTGRLEE KGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVL SNSGWGQTPIKQNTAWDTETSPRGERKTDNGTE AWGSSATQTFNSGACIDKTSPNGNDTSSVSGWG DPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQ WGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSV SASDNWGETSRNNHWGEANKKSSSGGSDSDRSV SGWNELGKTSSFTWGNNINPNNSSGWDESSKPTP SQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQD IVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEP TGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKN VNMWNKNVPNGNSRSDQQAQVHQLLTPASAISN KEASSGSGWGEPWGEPSTPATTVDNGTSAWGKP IDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSG PKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGM WNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRR RERGMMKGGNKQEEAWINPFVKQFSNISFSRDSP EENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDY NRTVGKGPGSRPQISKESSMERNPYFDKDGIVA DESQNMQFMSSQSMKLPPSNSALPNQALGSIAGL GMQNLNSVRQNGNPSMFGVGNTAAQPRGMQQPP AQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAP NNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQR LLAQQQRAQSQRSVPSGNRPQQDQQGRPLSVQQ QMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMK SFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSN LNVNMDMNSIKEPQSRLRKWTTVDSISVNTSLD QNSSKHGAISSGFRLEESPFVPYDFMNSSTSPA SPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPW KGYPNIDPETDPYVTPGSVINNLSINTVREVDH LRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVP LSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELW KVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSP LRIGGGWGNSDARYTPGSSWGESSSGRITNWLV LKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGN ALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFA SEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGS LDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSL WGTPHYSTSLWGPPSSSDPRGISSPSPINAFLS VDHLGGGGESM*QCRCRLTDRDLRREGKEH*VG LAACSQGPPVGTAILCTFSTLFSPKHISLNT*IM QANIIM*KGIYSIYTPK*RHTC*TVENELACVY SSCLAFGFFFFFSFYSSPTPPPAPFFLSCKTIF WADNV*AFPFALNDVLSVSSAVWGAAVPVSMFTQ GCS*EACALYYALMLPTLLWYRGV*KIKLGC*L RIINESVAPVFSCCKTKEFRSAV*KTVATAVTC SPPATQDGPCTLNRLSILFWRFSL*TFLFTDFFV CFLRKKNVYSSII*KKCKRQKKNGG*FKRCFLS LGKRSSIWPCSFVFLFLSQIKEHGSQENQFPSL KKKKKIPCSFLEEKKKNPNF*H*YYILLC*RIFS A

Frame 2

NLGSAVKVLNSQSESSALTNQQPQNNGEVQNSK NQSVNK*QILDSHQDLSDSKDMLVTTMLCFGNI QDVIGNEEEDTNI*TTVLQDPIMKIPSGDLCLL QVILAQTVRMLL*VTCRKKKHGPQPLAVIRSWLQ NVWMLILPPVLNQRETSLSWLQGTQVVKKMAFG IALDLVPKTSL*LVAAAIMWAMEVVLGHGVFPM EP**AHVRSLWMLLKANLKVATIE*MLGAL*VLH QMEG*IQAL*IQLATMVPGQY*RTMDLP*KGL* GVVVLALIFSAVL*ARCLTIRVLTLK*VVVLPM VPGEAFRKLVNLK*VVHRRFHSVVNLKILPLK*L DQITLLTL*PLVYQTPVQCRIMSCLVVTQGPGV *AQ*IILRCRLHQV*MALPFLTLAMESQKVEAL MVLHGVPMVLITLETNVQALMAKLMVTL*MQL*C SLA*MVLWALTFKLTQTKEVVCGNLVQQTPRVH HGEVEMAQILEEVEEDGEPLHKTLALIYPALSG TNCLAISIPMIVQMAMVRRLQMDGNLLRKRIRVL PHLRQMSKAVCGPKQEVQWRAMVVQKALDALRK KELGKVRVETEEKLISTHYSKAL*TELT*IHVS CPTLVGDRLLLSRILPGIQKHHLEGNERLTMGQR PGEALQHRLLTQGHV*IRLALMVMIPHLYQGGA IPNLL*GGEIPKAQTARGGGKMILLLQEWSRAI SGGIAKRRRLHGMTRKRINRDGVMDKNQAKGGLF LPVITGEKLQGITIGVRPIRNPAQEVVTVTGPF PVGTNLVKLVLSLGETT*IQIIHQDGMNLLNLL LPRDGETLQSLISL*VGEIRQSQSALQTGTSNKT LLDLGESHQLQANLLVQAGWGDLYQPQQKKKNP QAGRNHPQNLYVAKWRLMMELQLGEIQANTTTK M*TCGTKTSQMATAVQTSKHRYISC*RLQVPSQT KRQAVALAGVSPGGSLLLQPQLWIMVLQHGVSP *TVVPAGGNPLLRHPAHPRGAPALLVHKH*ANL GQNLCKMAGVVMICHCLEIAPLAGKRKRMWRLEC GIVIHLKSLTHL*IGHHIQRKCHRRV*VAKKGE GKGE**KVETNKKKRG*IHLLNSFQTSVFRETH QRKMYKAIRWTFLEECYKTNEWR*INIA*ILVIT IERSGKALVLGLRFPKSLPWSAILILIRMAL*Q MNPKTCSLCPVKA*SFPLQIVHYLTRPLAP*QG WVCKT*ILLDRMAIPVCLVLETQQHNPGACSSLQ HNLLVHLSLISVLKCLLHYSPLRFQFHC*SMHQ TTVA*IHSLALNR*PC*TSYPS*TSFLRSPSYS DC*RSSKGRRVREACLLGTGRSKTSRVDLLVCSS K*CNNLVNLIQTCW*SSRLHHLSSSHSISQP*S LSLTMSCPTLHLSCKKGHHQ*MLSATSL*A*TQ T*M*IWI*TVLKSHSQD*GSGRQWTAFL*THLWI KTPANMVLFQVVSGWKSLHLFPMTL*TAVLHQP VLQVQ*EMAGHVPNRLTALAVLIGHQNFVLVSH GKVIQTLTLKLTLTSLLAVS*TIFQLILCGKLTT SGTGTVGHPHP*TPRCLQLVPGHPFVPPTTTFP SAVQHKALQPEIVIPN*HGLLVQLQTPLWLMSC GRSLCHLKTSLLRPAHLRD*LVRSHPCLRGIILP FV*VEDGEILTPDIPQVPAGVRAAQGE*QIGLF *KTLHLRSMAQLCALCACSTAR*SHST*TSLTE MLWSATVQKKR**RHKSLCTCVYWGTLLFLLSLP VKRRSVVSLHKASL*PLLPAGSLSGPARAGWAP STVPTHSPAGPISITGMVLGCRELTVETFTALH SGGPRIIPQACGVPQAAATPEELAAHLPLTLFFL LTTWVGVESPCNSVDADSPTGTSDARERSTKWG SPPAARGRLWEQLFSAHFPLCFPQNISV*ILES CRPIL*CEKVSTLFTLPNSAIHAKP*RMSSLVSI HHV*PLDSFFFFPSIPPQPPPPPLFFSLAKPFF GLITYELFPLH*MMFSPSHRQYGGQLSQCQCLL KGVLRRRALSTMP*CCLPYCGIVEFKRSS*DADL GLLMKVLHQFFHVVKLKNFALQFEKLWPQL*LA AHLPPRTGPAL*IGFPFCFGGSHFEPSCLQIFL FVF*EKKMFTLPSFKKNVKDKKKMEDDLKDAFYL WEKGAAFGHVLLFFYSCPKSKSMVLRKTSSPV* KKKKKFLVVS*RKKRKTPTFSTDTTYCSVKEFS L