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Sequences

Sequence NM_175610

CGGGCATGCTCAGTGGGCCGGGCCGGCAGGTTTGCGTGGCCGCTGAGTTGCCGGCGCCGGCTGAGCCAGCGGACGCCGCGTTCCTTGGCGGCCGCCGGTT CCCGGGAAGTTACGTGGCGAAGCCGGCTTCCGAGGAGACGCCGGGAGGCCACGGGTGCTGCTGACGGGCGGGCGACCGGGCGAGGCCGACGTGGCCGGGC TGCGAAAGCTGCGGGAGGCCGAGTGGGTGGCCGCGCTCGGAGGGAGGTGCCGGTCGGGCGCGCCCCGTGGAGAAGACCCGGGCGGGGCGGGCGCTTCCCG GACTTTTGTCCGAGTTGAATTCCCTCCCCCTGGGCCGGGCCCTTCCGGCCGCCCCCGCCCGTGCCCCGCTCGCTCTCGGGAGATGTTTATTTGGGCTGTG GCGTGAGGAGCGGGCGGGCCAGCGCCGCGGAGTTTCGGGTCCGAGGAGCCTCGCGCGGCGCTGGAGAGAGACAAGATGTCCGCCAGAGCTGCGGCCGCCA AGAGCACAGCAATGGAGGAAACAGCTATATGGGAACAACATACAGTGACGCTTCACAGGGCTCCTGGATTTGGATTTGGAATTGCAATATCTGGTGGACG AGATAATCCTCATTTTCAGAGTGGGGAAACGTCAATAGTGATTTCAGATGTGCTGAAAGGAGGACCAGCTGAAGGACAGCTACAGGAAAATGACCGAGTT GCAATGGTTAACGGAGTTTCAATGGATAATGTTGAACATGCTTTTGCTGTTCAGCAACTAAGGAAAAGTGGGAAAAATGCAAAAATTACAATTAGAAGGA AGAAGAAAGTTCAAATACCAGTAAGTCGTCCTGATCCTGAACCAGTATCTGATAATGAAGAAGATAGTTATGATGAGGAAATACATGATCCAAGAAGTGG CCGGAGTGGTGTGGTTAACAGAAGGAGTGAGAAGATTTGGCCGAGGGATAGAAGTGCAAGTAGAGAGAGGAGCTTGTCCCCGCGGTCAGACAGGCGGTCA GTGGCTTCCAGCCAGCCTGCTAAACCTACTAAAGTCACACTGGTGAAATCCCGGAAAAATGAAGAATATGGTCTTCGATTGGCAAGCCATATATTTGTTA AGGAAATTTCACAAGATAGTTTGGCAGCAAGAGATGGCAATATTCAAGAAGGTGATGTTGTATTGAAGATAAATGGTACTGTGACAGAAAATATGTCATT GACAGATGCAAAGACATTGATAGAAAGGTCTAAAGGCAAATTAAAAATGGTAGTTCAAAGAGATGAACGGGCTACGCTATTGAATGTCCCTGATCTTTCT GACAGCATCCACTCTGCTAATGCCTCTGAGAGAGACGACATTTCAGAAATTCAGTCACTGGCATCAGATCATTCTGGTCGATCACACGATAGGCCTCCCC GCCGCAGCCGGTCACGATCTCCTGACCAGCGGTCAGAGCCTTCTGATCATTCCAGGCACTCGCCGCAGCAGCCAAGCAATGGCAGTCTCCGGAGTAGAGA TGAAGAGAGAATTTCTAAACCTGGGGCTGTCTCAACTCCTGTAAAGCATGCTGATGATCACACACCTAAAACAGTGGAAGAAGTTACAGTTGAAAGAAAT GAGAAACAAACACCTTCTCTTCCAGAACCAAAGCCTGTGTATGCCCAAGTTGGGCAACCAGATGTGGATTTACCTGTCAGTCCATCTGATGGTGTCCTAC CTAATTCAACTCATGAAGATGGGATTCTTCGGCCCAGCATGAAATTGGTAAAATTCAGAAAAGGAGATAGTGTGGGTTTGCGGCTGGCTGGTGGAAATGA TGTTGGAATATTTGTAGCTGGCGTTCTAGAAGATAGCCCTGCAGCCAAGGAAGGCTTAGAGGAAGGTGATCAAATTCTCAGGGTAAACAACGTAGATTTT ACAAATATCATAAGAGAAGAAGCCGTCCTTTTCCTGCTTGACCTCCCTAAAGGAGAAGAAGTGACCATATTGGCTCAGAAGAAGAAGGATGTTTATCGTC GCATTGTAGAATCAGATGTAGGAGATTCTTTCTATATTAGAACCCATTTTGAATATGAAAAGGAATCTCCCTATGGACTTAGTTTTAACAAAGGAGAGGT GTTCCGTGTTGTGGATACCTTGTACAATGGAAAACTGGGCTCTTGGCTTGCTATTCGAATTGGTAAAAATCATAAGGAGGTAGAACGAGGCATCATCCCT AATAAGAACAGAGCTGAGCAGCTAGCCAGTGTACAGTATACACTTCCAAAAACAGCAGGCGGAGACCGTGCTGACTTCTGGAGATTCAGAGGTCTTCGCA GCTCCAAGAGAAATCTTCGAAAAAGCAGAGAGGATTTGTCCGCTCAGCCTGTTCAAACAAAGTTTCCAGCTTATGAAAGAGTGGTTCTTCGAGAAGCTGG ATTTCTGAGGCCTGTAACCATTTTTGGACCAATAGCTGATGTTGCCAGAGAAAAGCTGGCAAGAGAAGAACCAGATATTTATCAAATTGCAAAGAGTGAA CCACGAGACGCTGGAACTGACCAACGTAGCTCTGGCATTATTCGCCTGCATACAATAAAGCAAATCATAGATCAAGACAAACATGCTTTATTAGATGTAA CACCAAATGCAGTTGATCGTCTTAACTATGCCCAGTGGTATCCAATTGTTGTATTTCTTAACCCTGATTCTAAGCAAGGAGTAAAAACAATGAGAATGAG GTTATGTCCAGAATCTCGGAAAAGTGCCAGGAAGTTATACGAGCGATCTCATAAACTTCGTAAAAATAATCACCATCTTTTTACAACTACAATTAACTTA AATTCAATGAATGATGGTTGGTATGGTGCGCTGAAAGAAGCAATTCAACAACAGCAAAACCAGCTGGTATGGGTTTCCGAGGGAAAGGCGGATGGTGCTA CAAGTGATGACCTTGATTTGCATGATGATCGTCTGTCCTACCTGTCAGCTCCAGGTAGTGAATACTCAATGTATAGCACGGACAGTAGACACACTTCTGA CTATGAAGACACAGACACAGAAGGCGGGGCCTACACTGATCAAGAACTAGATGAAACTCTTAATGATGAGGTTGGGACTCCACCGGAGTCTGCCATTACA CGGTCCTCTGAGCCTGTAAGAGAGGACTCCTCTGGAATGCATCATGAAAACCAAACATATCCTCCTTACTCACCACAAGCGCAGCCACAACCAATTCATA GAATAGACTCCCCTGGATTTAAGCCAGCCTCTCAACAGGTGTATAGAAAGGATCCATATCCCGAGGAAATGATGAGGCAGAACCATGTTTTGAAACAGCC AGCCGTTAGTCACCCAGGGCACAGGCCAGACAAAGAGCCTAATCTGACCTATGAACCCCAACTCCCATACGTAGAGAAACAAGCCAGCAGAGACCTCGAG CAGCCCACATACAGATACGAGTCCTCAAGCTATACGGACCAGTTTTCTCGAAACTATGAACATCGTCTGCGATACGAAGATCGCGTCCCCATGTATGAAG AACAGTGGTCATATTATGATGACAAACAGCCCTACCCATCTCGGCCACCTTTTGATAATCAGCACTCTCAAGACCTTGACTCCAGACAGCATCCCGAAGA GTCCTCAGAACGAGGGTACTTTCCACGTTTTGAAGAGCCAGCCCCTCTGTCTTACGACAGCAGACCACGTTACGAACAGGCACCTAGAGCATCCGCCCTG CGGCACGAAGAGCAGCCAGCTCCTGGGTATGACACACATGGTAGACTCAGACCGGAAGCCCAGCCCCACCCTTCAGCAGGGCCCAAGCCTGCAGAGTCCA AGCAGTATTTTGAGCAATATTCACGCAGTTACGAGCAAGTACCACCCCAAGGATTTACCTCTAGAGCAGGTCATTTTGAGCCTCTCCATGGTGCTGCAGC TGTCCCTCCGCTGATACCTTCATCTCAGCATAAGCCAGAAGCTCTGCCTTCAAACACCAAACCACTGCCTCCACCCCCAACTCAAACCGAAGAAGAGGAA GATCCAGCAATGAAGCCACAGTCTGTACTCACCAGAGTTAAGATGTTTGAAAACAAAAGATCTGCATCCTTAGAGACCAAGAAGGATGTAAATGACACTG GCAGTTTTAAGCCTCCAGAAGTAGCATCTAAACCTTCAGGTGCTCCCATCATTGGTCCCAAACCCACTTCTCAGAATCAATTCAGTGAACATGACAAAAC TCTGTACAGGATCCCAGAACCTCAAAAACCTCAACTGAAGCCACCTGAAGATATTGTTCGGTCCAATCATTATGACCCTGAAGAAGATGAAGAATATTAT CGAAAACAGCTGTCATACTTTGACCGAAGAAGTTTTGAGAATAAGCCTCCTGCACACATTGCCGCCAGCCATCTCTCCGAGCCTGCAAAGCCAGCGCATT CTCAGAATCAATCAAATTTTTCTAGTTATTCTTCAAAGGGAAAGCCTCCTGAAGCTGATGGTGTGGATAGATCATTTGGCGAGAAACGCTATGAACCCAT CCAGGCCACTCCCCCTCCTCCTCCATTGCCCTCGCAGTATGCCCAGCCATCTCAGCCTGTCACCAGCGCGTCTCTCCACATACATTCTAAGGGAGCACAT GGTGAAGGTAATTCAGTGTCATTGGATTTTCAGAATTCCTTAGTGTCCAAACCAGACCCACCTCCATCTCAGAATAAGCCAGCAACTTTCAGACCACCAA ACCGAGAAGATACTGCTCAGGCAGCTTTCTATCCCCAGAAAAGTTTTCCAGATAAAGCCCCAGTTAATGGAACTGAACAGACTCAGAAAACAGTCACTCC AGCATACAATCGATTCACACCAAAACCATATACAAGTTCTGCCCGACCATTTGAACGCAAGTTTGAAAGTCCTAAATTCAATCACAATCTTCTGCCAAGT GAAACTGCACATAAACCTGACTTGTCTTCAAAAACTCCCACTTCTCCAAAAACTCTTGTGAAATCGCACAGTTTGGCACAGCCTCCTGAGTTTGACAGTG GAGTTGAAACTTTCTCTATCCATGCAGAGAAGCCTAAATATCAAATAAATAATATCAGCACAGTGCCTAAAGCTATTCCTGTGAGTCCTTCAGCTGTGGA AGAGGATGAAGATGAAGATGGTCATACTGTGGTGGCCACAGCCCGAGGCATATTTAACAGCAATGGGGGCGTGCTGAGTTCCATAGAAACTGGTGTTAGT ATAATTATCCCTCAAGGAGCCATTCCCGAAGGAGTTGAGCAGGAAATCTATTTCAAGGTCTGCCGGGACAACAGCATCCTTCCACCTTTAGATAAAGAGA AAGGTGAAACACTGCTGAGTCCTTTGGTGATGTGTGGTCCCCATGGCCTCAAGTTCCTGAAGCCTGTGGAGCTGCGCTTACCACACTGTGATCCTAAAAC CTGGCAAAACAAGTGTCTTCCCGGAGATCCAAATTATCTCGTTGGAGCAAACTGTGTTTCTGTCCTTATTGACCACTTTTAACTCTTGAAATATAGGAAC TTAAATAATGTGAAACTGGATTAAACTTAATCTAAATGGAACCACTCTATCAAGTATTATACCTTTTTTAGAGTTGATACTACAGTTTGTTAGTATGAGG CATTTGTTTGAACTGATAAAGATGAGTGAGCATGCCCCTGAACCATGGTCGGAAAACATGCTACACACTGCATGTTTGTGATTGACGGGACTGTTGGTAT TGGCTAGAGGTTCAAAGATATTTTGCTTTGTGATTTTTGTAATTTTTTTATCGTCACTGCTTAACTTCACATATTGATTTCCGTTAAAATACCAGCCAGT AAATGGGGGTGCATTTGAGGTCTGTTCTTTCCAAAGTACACTGTTTCAAACTTTACTATGGCCCTGGCCTAGCATACGTACACATTTTATTTTATTATGC ATGAAGTAATATGCACACATTTTTTAAATGCACCTGGAATATATAACCAGTGTTGTGGATTTAACAGAAATGTACAGCAAGGAGATTTACAACTGGGGGA GGGTGAAGTGAAGACAATGACTTACTGTACATGAAAACACATTTTTCTTAGGGAAGGATACAAAAGCATGTGAGACTGGTTCCATGGCCTCTTCAGATCT CTAACTTCACCATATTACCACAGACATACTAACCAGCAGAAATGCCTTACCCTCATGTTCTTAATTCTTAGCTCATTCTCCTTGTGTTACTAAGTTTTTA TGGCTTTTGTGCATTATCTAGATACTGTATCATGACAAAGACTGAGTACGTTGTGCATTTGGTGGTTTCAGAAATGTGTTATCACCCAGAAGAAAATAGT GGTGTGATTTGGGGATATTTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTTTGACAAGGGGCAGTGGTGGTTTTCTGTTCTTTCTGGCTATGCATTT GAAAATTTTGATGTTTTAAGGATGCTTGTACATAATGCGTGCATACCACTTTTGTTCTTGGTTTGTAAATTAACTTTTATAAACTTTACCTTTTTTATAC ATAAACAAGACCACGTTTCTAAAGGCTACCTTTGTATTCTCTCCTGTACCTCTTGAGCCTTGAACTTTGACCTCTGCAGCAATAAAGCAGCGTTTCTATG ACACATGCAAGGTCATTTTTTTTAAGAAAAAGGATGCACAGAGTTGTTACATTTTTAAGTGCTGCATTTAAAAGATACAGTTACTCAGAATTCTCTAGTT TGATTAAATTCTTGCAAAGTATCCCTACTGTAATTTGTGATACAATGCTGTGCCCTAAAGTGTATTTTTTTACTAATAGACAATTTATTATGGCACATCA GCACGATTTCTGTTTAGATAATACACCACTACATTCTGTTAATCATTAGGTGTGACTGAATTTCTTTTGCCGTTATTAAAAATCTCAAATTTCTAAATCT CCAAAATAAAACTTTTTAAAATAAA

refseq_TJP1.F1 (forward primer)
refseq_TJP1.R1 (reverse primer)
Single exon skipping

Frame 0

RACSVGRAGRFAWPLSCRRRLSQRTPRSLAAAG SREVTWRSRLPRRRREATGAADGRATGRGRRGRA AKAAGGRVGGRARREVPVGRAPWRRPGRGGRFP DFCPS*IPSPWAGPFRPPPPVPRSLSGDVYLGC GVRSGRASAAEFRVRGASRGAGERQDVRQSCGRQ EHSNGGNSYMGTTYSDASQGSWIWIWNCNIWWT R*SSFSEWGNVNSDFRCAERRTS*RTATGK*PS CNG*RSFNG*C*TCFCCSATKEKWEKCKNYN*KE EESSNTSKSS*S*TSI***RR*L**GNT*SKKW PEWCG*QKE*EDLAEG*KCK*REELVPAVRQAV SGFQPAC*TY*SHTGEIPEK*RIWSSIGKPYIC* GNFTR*FGSKRWQYSRR*CCIEDKWYCDRKYVI DRCKDIDRKV*RQIKNGSSKR*TGYAIECP*SF *QHPLC*CL*ERRHFRNSVTGIRSFWSITR*ASP PQPVTIS*PAVRAF*SFQALAAAAKQWQSPE*R *RENF*TWGCLNSCKAC**SHT*NSGRSYS*KK *ETNTFSSRTKACVCPSWATRCGFTCQSI*WCPT *FNS*RWDSSAQHEIGKIQKRR*CGFAAGWWK* CWNICSWRSRR*PCSQGRLRGR*SNSQGKQRRF YKYHKRRSRPFPA*PP*RRRSDHIGSEEEGCLSS HCRIRCRRFFLY*NPF*I*KGISLWT*F*QRRG VPCCGYLVQWKTGLLACYSNW*KS*GGRTRHHP **EQS*AASQCTVYTSKNSRRRPC*LLEIQRSSQ LQEKSSKKQRGFVRSACSNKVSSL*KSGSSRSW ISEACNHFWTNS*CCQRKAGKRRTRYLSNCKE* TTRRWN*PT*LWHYSPAYNKANHRSRQTCFIRCN TKCS*SS*LCPVVSNCCIS*P*F*ARSKNNENE VMSRISEKCQEVIRAIS*TS*K*SPSFYNYN*L KFNE*WLVWCAERSNSTTAKPAGMGFRGKGGWCY K**P*FA**SSVLPVSSR**ILNV*HGQ*THF* L*RHRHRRRGLH*SRTR*NS***GWDSTGVCHY TVL*ACKRGLLWNAS*KPNISSLLTTSAATTNS* NRLPWI*ASLSTGV*KGSISRGNDEAEPCFETA SR*SPRAQARQRA*SDL*TPTPIRRETSQQRPR AAHIQIRVLKLYGPVFSKL*TSSAIRRSRPHV*R TVVIL**QTALPISATF**SALSRP*LQTASRR VLRTRVLSTF*RASPSVLRQQTTLRTGT*SIRP AARRAASSWV*HTW*TQTGSPAPPFSRAQACRVQ AVF*AIFTQLRASTTPRIYL*SRSF*ASPWCCS CPSADTFISA*ARSSAFKHQTTASTPNSNRRRG RSSNEATVCTHQS*DV*KQKICILRDQEGCK*HW QF*ASRSSI*TFRCSHHWSQTHFSESIQ*T*QN SVQDPRTSKTSTEAT*RYCSVQSL*P*RR*RIL SKTAVIL*PKKF*E*ASCTHCRQPSLRACKASAF SESIKFF*LFFKGKAS*S*WCG*IIWRETL*TH PGHSPSSSIALAVCPAISACHQRVSPHTF*GST W*R*FSVIGFSEFLSVQTRPTSISE*ASNFQTTK PRRYCSGSFLSPEKFSR*SPS*WN*TDSENSHS SIQSIHTKTIYKFCPTI*TQV*KS*IQSQSSAK *NCT*T*LVFKNSHFSKNSCEIAQFGTAS*V*QW S*NFLYPCREA*ISNK*YQHSA*SYSCESFSCG RG*R*RWSYCGGHSPRHI*QQWGRAEFHRNWC* YNYPSRSHSRRS*AGNLFQGLPGQQHPSTFR*RE R*NTAESFGDVWSPWPQVPEACGAALTTL*S*N LAKQVSSRRSKLSRWSKLCFCPY*PLLTLEI*E LK*CETGLNLI*MEPLYQVLYLF*S*YYSLLV*G ICLN**R*VSMPLNHGRKTCYTLHVCD*RDCWY WLEVQRYFAL*FL*FFYRHCLTSHIDFR*NTSQ *MGVHLRSVLSKVHCFKLYYGPGLAYVHILFYYA *SNMHTFFKCTWNI*PVLWI*QKCTARRFTTGG G*SEDNDLLYMKTHFS*GRIQKHVRLVPWPLQI SNFTILPQTY*PAEMPYPHVLNS*LILLVLLSFY GFCALSRYCIMTKTEYVVHLVVSEMCYHPEENS GVIWGYFFLFFSFLFFFF*QGAVVVFCSFWLCI *KF*CFKDACT*CVHTTFVLGL*INFYKLYLFYT *TRPRF*RLPLYSLLYLLSLEL*PLQQ*SSVSM THARSFFLRKRMHRVVTFLSAAFKRYSYSEFSS LIKFLQSIPTVICDTMLCPKVYFFTNRQFIMAHQ HDFCLDNTPLHSVNH*V*LNFFCRY*KSQISKS PK*NFLK*

Frame 1

GHAQWAGPAGLRGR*VAGAG*ASGRRVPWRPPV PGKLRGEAGFRGDAGRPRVLLTGGRPGEADVAG LRKLREAEWVAALGGRCRSGAPRGEDPGGAGASR TFVRVEFPPPGPGPSGRPRPCPARSREMFIWAV A*GAGGPAPRSFGSEEPRAALERDKMSARAAAA KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR DNPHFQSGETSIVISDVLKGGPAEGQLQENDRV AMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRR KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSG RSGVVNRRSEKIWPRDRSASRERSLSPRSDRRS VASSQPAKPTKVTLVKSRKNEEYGLRLASHIFV KEISQDSLAARDGNIQEGDVVLKINGTVTENMSL TDAKTLIERSKGKLKMVVQRDERATLLNVPDLS DSIHSANASERDDISEIQSLASDHSGRSHDRPP RRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD EERISKPGAVSTPVKHADDHTPKTVEEVTVERN EKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVL PNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND VGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDF TNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIP NKNRAEQLASVQYTLPKTAGGDRADFWRFRGLR SSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG FLRPVTIFGPIADVAREKLAREEPDIYQIAKSE PRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDV TPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMR LCPESRKSARKLYERSHKLRKNNHHLFTTTINL NSMNDGWYGALKEAIQQQQNQLVWVSEGKADGA TSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD YEDTDTEGGAYTDQELDETLNDEVGTPPESAIT RSSEPVREDSSGMHHENQTYPPYSPQAQPQPIH RIDSPGFKPASQQVYRKDPYPEEMMRQNHVLKQP AVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLE QPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYE EQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE SSERGYFPRFEEPAPLSYDSRPRYEQAPRASAL RHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAES KQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAA VPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEE DPAMKPQSVLTRVKMFENKRSASLETKKDVNDT GSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYY RKQLSYFDRRSFENKPPAHIAASHLSEPAKPAH SQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAH GEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPP NREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTP AYNRFTPKPYTSSARPFERKFESPKFNHNLLPS ETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDS GVETFSIHAEKPKYQINNISTVPKAIPVSPSAVE EDEDEDGHTVVATARGIFNSNGGVLSSIETGVS IIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKE KGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKT WQNKCLPGDPNYLVGANCVSVLIDHF*LLKYRN LNNVKLD*T*SKWNHSIKYYTFFRVDTTVC*YE AFV*TDKDE*ACP*TMVGKHATHCMFVIDGTVGI G*RFKDILLCDFCNFFIVTA*LHILISVKIPAS KWGCI*GLFFPKYTVSNFTMALA*HTYTFYFIM HEVICTHFLNAPGIYNQCCGFNRNVQQGDLQLGE GEVKTMTYCT*KHIFLREGYKSM*DWFHGLFRS LTSPYYHRHTNQQKCLTLMFLILSSFSLCY*VF MAFVHYLDTVS*QRLSTLCIWWFQKCVITQKKIV V*FGDIFFFSFLFFFFFFDKGQWWFSVLSGYAF ENFDVLRMLVHNACIPLLFLVCKLTFINFTFFI HKQDHVSKGYLCILSCTS*ALNFDLCSNKAAFL* HMQGHFF*EKGCTELLHF*VLHLKDTVTQNSLV *LNSCKVSLL*FVIQCCALKCIFLLIDNLLWHI STISV*IIHHYILLIIRCD*ISFAVIKNLKFLNL QNKTF*NK

Frame 2

GMLSGPGRQVCVAAELPAPAEPADAAFLGGRRF PGSYVAKPASEETPGGHGCC*RAGDRARPTWPG CESCGRPSGWPRSEGGAGRARPVEKTRAGRALP GLLSELNSLPLGRALPAAPARAPLALGRCLFGLW REERAGQRRGVSGPRSLARRWRETRCPPELRPP RAQQWRKQLYGNNIQ*RFTGLLDLDLELQYLVD EIILIFRVGKRQ**FQMC*KEDQLKDSYRKMTEL QWLTEFQWIMLNMLLLFSN*GKVGKMQKLQLEG RRKFKYQ*VVLILNQYLIMKKIVMMRKYMIQEV AGVVWLTEGVRRFGRGIEVQVERGACPRGQTGGQ WLPASLLNLLKSHW*NPGKMKNMVFDWQAIYLL RKFHKIVWQQEMAIFKKVMLY*R*MVL*QKICH *QMQRH**KGLKAN*KW*FKEMNGLRY*MSLIFL TASTLLMPLRETTFQKFSHWHQIILVDHTIGLP AAAGHDLLTSGQSLLIIPGTRRSSQAMAVSGVE MKREFLNLGLSQLL*SMLMITHLKQWKKLQLKEM RNKHLLFQNQSLCMPKLGNQMWIYLSVHLMVSY LIQLMKMGFFGPA*NW*NSEKEIVWVCGWLVEM MLEYL*LAF*KIALQPRKA*RKVIKFSG*TT*IL QIS*EKKPSFSCLTSLKEKK*PYWLRRRRMFIV AL*NQM*EILSILEPILNMKRNLPMDLVLTKER CSVLWIPCTMENWALGLLFELVKIIRR*NEASSL IRTELSS*PVYSIHFQKQQAETVLTSGDSEVFA APREIFEKAERICPLSLFKQSFQLMKEWFFEKL DF*GL*PFLDQ*LMLPEKSWQEKNQIFIKLQRVN HETLELTNVALALFACIQ*SKS*IKTNMLY*M* HQMQLIVLTMPSGIQLLYFLTLILSKE*KQ*E* GYVQNLGKVPGSYTSDLINFVKIITIFLQLQLT* IQ*MMVGMVR*KKQFNNSKTSWYGFPRERRMVL QVMTLICMMIVCPTCQLQVVNTQCIARTVDTLL TMKTQTQKAGPTLIKN*MKLLMMRLGLHRSLPLH GPLSL*ERTPLECIMKTKHILLTHHKRSHNQFI E*TPLDLSQPLNRCIERIHIPRK**GRTMF*NS QPLVTQGTGQTKSLI*PMNPNSHT*RNKPAETSS SPHTDTSPQAIRTSFLETMNIVCDTKIASPCMK NSGHIMMTNSPTHLGHLLIISTLKTLTPDSIPK SPQNEGTFHVLKSQPLCLTTADHVTNRHLEHPPC GTKSSQLLGMTHMVDSDRKPSPTLQQGPSLQSP SSILSNIHAVTSKYHPKDLPLEQVILSLSMVLQ LSLR*YLHLSISQKLCLQTPNHCLHPQLKPKKRK IQQ*SHSLYSPELRCLKTKDLHP*RPRRM*MTL AVLSLQK*HLNLQVLPSLVPNPLLRINSVNMTK LCTGSQNLKNLN*SHLKILFGPIIMTLKKMKNII ENSCHTLTEEVLRISLLHTLPPAISPSLQSQRI LRINQIFLVILQRESLLKLMVWIDHLARNAMNP SRPLPLLLHCPRSMPSHLSLSPARLSTYILREHM VKVIQCHWIFRIP*CPNQTHLHLRISQQLSDHQ TEKILLRQLSIPRKVFQIKPQLMELNRLRKQSL QHTIDSHQNHIQVLPDHLNASLKVLNSITIFCQV KLHINLTCLQKLPLLQKLL*NRTVWHSLLSLTV ELKLSLSMQRSLNIK*IISAQCLKLFL*VLQLW KRMKMKMVILWWPQPEAYLTAMGAC*VP*KLVLV *LSLKEPFPKELSRKSISRSAGTTASFHL*IKR KVKHC*VLW*CVVPMASSS*SLWSCAYHTVILK PGKTSVFPEIQIISLEQTVFLSLLTTFNS*NIGT *IM*NWIKLNLNGTTLSSIIPFLELILQFVSMR HLFELIKMSEHAPEPWSENMLHTACL*LTGLLV LARGSKIFCFVIFVIFLSSLLNFTY*FPLKYQPV NGGAFEVCSFQSTLFQTLLWPWPSIRTHFILLC MK*YAHIF*MHLEYITSVVDLTEMYSKEIYNWG RVK*RQ*LTVHENTFFLGKDTKACETGSMASSDL *LHHITTDILTSRNALPSCS*FLAHSPCVTKFL WLLCII*ILYHDKD*VRCAFGGFRNVLSPRRK* WCDLGIFFSFLFFSFFFFLTRGSGGFLFFLAMHL KILMF*GCLYIMRAYHFCSWFVN*LL*TLPFLY INKTTFLKATFVFSPVPLEP*TLTSAAIKQRFY DTCKVIFFKKKDAQSCYIFKCCI*KIQLLRIL*F D*ILAKYPYCNL*YNAVP*SVFFY**TIYYGTS ARFLFR*YTTTFC*SLGVTEFLLPLLKISNF*I SKIKLFKI

Sequence NM_003257

CGGGCATGCTCAGTGGGCCGGGCCGGCAGGTTTGCGTGGCCGCTGAGTTGCCGGCGCCGGCTGAGCCAGCGGACGCCGCGTTCCTTGGCGGCCGCCGGTT CCCGGGAAGTTACGTGGCGAAGCCGGCTTCCGAGGAGACGCCGGGAGGCCACGGGTGCTGCTGACGGGCGGGCGACCGGGCGAGGCCGACGTGGCCGGGC TGCGAAAGCTGCGGGAGGCCGAGTGGGTGGCCGCGCTCGGAGGGAGGTGCCGGTCGGGCGCGCCCCGTGGAGAAGACCCGGGCGGGGCGGGCGCTTCCCG GACTTTTGTCCGAGTTGAATTCCCTCCCCCTGGGCCGGGCCCTTCCGGCCGCCCCCGCCCGTGCCCCGCTCGCTCTCGGGAGATGTTTATTTGGGCTGTG GCGTGAGGAGCGGGCGGGCCAGCGCCGCGGAGTTTCGGGTCCGAGGAGCCTCGCGCGGCGCTGGAGAGAGACAAGATGTCCGCCAGAGCTGCGGCCGCCA AGAGCACAGCAATGGAGGAAACAGCTATATGGGAACAACATACAGTGACGCTTCACAGGGCTCCTGGATTTGGATTTGGAATTGCAATATCTGGTGGACG AGATAATCCTCATTTTCAGAGTGGGGAAACGTCAATAGTGATTTCAGATGTGCTGAAAGGAGGACCAGCTGAAGGACAGCTACAGGAAAATGACCGAGTT GCAATGGTTAACGGAGTTTCAATGGATAATGTTGAACATGCTTTTGCTGTTCAGCAACTAAGGAAAAGTGGGAAAAATGCAAAAATTACAATTAGAAGGA AGAAGAAAGTTCAAATACCAGTAAGTCGTCCTGATCCTGAACCAGTATCTGATAATGAAGAAGATAGTTATGATGAGGAAATACATGATCCAAGAAGTGG CCGGAGTGGTGTGGTTAACAGAAGGAGTGAGAAGATTTGGCCGAGGGATAGAAGTGCAAGTAGAGAGAGGAGCTTGTCCCCGCGGTCAGACAGGCGGTCA GTGGCTTCCAGCCAGCCTGCTAAACCTACTAAAGTCACACTGGTGAAATCCCGGAAAAATGAAGAATATGGTCTTCGATTGGCAAGCCATATATTTGTTA AGGAAATTTCACAAGATAGTTTGGCAGCAAGAGATGGCAATATTCAAGAAGGTGATGTTGTATTGAAGATAAATGGTACTGTGACAGAAAATATGTCATT GACAGATGCAAAGACATTGATAGAAAGGTCTAAAGGCAAATTAAAAATGGTAGTTCAAAGAGATGAACGGGCTACGCTATTGAATGTCCCTGATCTTTCT GACAGCATCCACTCTGCTAATGCCTCTGAGAGAGACGACATTTCAGAAATTCAGTCACTGGCATCAGATCATTCTGGTCGATCACACGATAGGCCTCCCC GCCGCAGCCGGTCACGATCTCCTGACCAGCGGTCAGAGCCTTCTGATCATTCCAGGCACTCGCCGCAGCAGCCAAGCAATGGCAGTCTCCGGAGTAGAGA TGAAGAGAGAATTTCTAAACCTGGGGCTGTCTCAACTCCTGTAAAGCATGCTGATGATCACACACCTAAAACAGTGGAAGAAGTTACAGTTGAAAGAAAT GAGAAACAAACACCTTCTCTTCCAGAACCAAAGCCTGTGTATGCCCAAGTTGGGCAACCAGATGTGGATTTACCTGTCAGTCCATCTGATGGTGTCCTAC CTAATTCAACTCATGAAGATGGGATTCTTCGGCCCAGCATGAAATTGGTAAAATTCAGAAAAGGAGATAGTGTGGGTTTGCGGCTGGCTGGTGGAAATGA TGTTGGAATATTTGTAGCTGGCGTTCTAGAAGATAGCCCTGCAGCCAAGGAAGGCTTAGAGGAAGGTGATCAAATTCTCAGGGTAAACAACGTAGATTTT ACAAATATCATAAGAGAAGAAGCCGTCCTTTTCCTGCTTGACCTCCCTAAAGGAGAAGAAGTGACCATATTGGCTCAGAAGAAGAAGGATGTTTATCGTC GCATTGTAGAATCAGATGTAGGAGATTCTTTCTATATTAGAACCCATTTTGAATATGAAAAGGAATCTCCCTATGGACTTAGTTTTAACAAAGGAGAGGT GTTCCGTGTTGTGGATACCTTGTACAATGGAAAACTGGGCTCTTGGCTTGCTATTCGAATTGGTAAAAATCATAAGGAGGTAGAACGAGGCATCATCCCT AATAAGAACAGAGCTGAGCAGCTAGCCAGTGTACAGTATACACTTCCAAAAACAGCAGGCGGAGACCGTGCTGACTTCTGGAGATTCAGAGGTCTTCGCA GCTCCAAGAGAAATCTTCGAAAAAGCAGAGAGGATTTGTCCGCTCAGCCTGTTCAAACAAAGTTTCCAGCTTATGAAAGAGTGGTTCTTCGAGAAGCTGG ATTTCTGAGGCCTGTAACCATTTTTGGACCAATAGCTGATGTTGCCAGAGAAAAGCTGGCAAGAGAAGAACCAGATATTTATCAAATTGCAAAGAGTGAA CCACGAGACGCTGGAACTGACCAACGTAGCTCTGGCATTATTCGCCTGCATACAATAAAGCAAATCATAGATCAAGACAAACATGCTTTATTAGATGTAA CACCAAATGCAGTTGATCGTCTTAACTATGCCCAGTGGTATCCAATTGTTGTATTTCTTAACCCTGATTCTAAGCAAGGAGTAAAAACAATGAGAATGAG GTTATGTCCAGAATCTCGGAAAAGTGCCAGGAAGTTATACGAGCGATCTCATAAACTTCGTAAAAATAATCACCATCTTTTTACAACTACAATTAACTTA AATTCAATGAATGATGGTTGGTATGGTGCGCTGAAAGAAGCAATTCAACAACAGCAAAACCAGCTGGTATGGGTTTCCGAGGGAAAGGCGGATGGTGCTA CAAGTGATGACCTTGATTTGCATGATGATCGTCTGTCCTACCTGTCAGCTCCAGGTAGTGAATACTCAATGTATAGCACGGACAGTAGACACACTTCTGA CTATGAAGACACAGACACAGAAGGCGGGGCCTACACTGATCAAGAACTAGATGAAACTCTTAATGATGAGGTTGGGACTCCACCGGAGTCTGCCATTACA CGGTCCTCTGAGCCTGTAAGAGAGGACTCCTCTGGAATGCATCATGAAAACCAAACATATCCTCCTTACTCACCACAAGCGCAGCCACAACCAATTCATA GAATAGACTCCCCTGGATTTAAGCCAGCCTCTCAACAGAAAGCAGAAGCTTCATCTCCAGTCCCTTACCTTTCGCCTGAAACAAACCCAGCATCATCAAC CTCTGCTGTTAATCATAATGTAAATTTAACTAATGTCAGACTGGAGGAGCCCACCCCAGCTCCTTCCACCTCTTACTCACCACAAGCTGATTCTTTAAGA ACACCAAGTACTGAGGCAGCTCACATAATGCTAAGAGATCAAGAACCATCATTGTCGTCGCATGTAGATCCAACAAAGGTGTATAGAAAGGATCCATATC CCGAGGAAATGATGAGGCAGAACCATGTTTTGAAACAGCCAGCCGTTAGTCACCCAGGGCACAGGCCAGACAAAGAGCCTAATCTGACCTATGAACCCCA ACTCCCATACGTAGAGAAACAAGCCAGCAGAGACCTCGAGCAGCCCACATACAGATACGAGTCCTCAAGCTATACGGACCAGTTTTCTCGAAACTATGAA CATCGTCTGCGATACGAAGATCGCGTCCCCATGTATGAAGAACAGTGGTCATATTATGATGACAAACAGCCCTACCCATCTCGGCCACCTTTTGATAATC AGCACTCTCAAGACCTTGACTCCAGACAGCATCCCGAAGAGTCCTCAGAACGAGGGTACTTTCCACGTTTTGAAGAGCCAGCCCCTCTGTCTTACGACAG CAGACCACGTTACGAACAGGCACCTAGAGCATCCGCCCTGCGGCACGAAGAGCAGCCAGCTCCTGGGTATGACACACATGGTAGACTCAGACCGGAAGCC CAGCCCCACCCTTCAGCAGGGCCCAAGCCTGCAGAGTCCAAGCAGTATTTTGAGCAATATTCACGCAGTTACGAGCAAGTACCACCCCAAGGATTTACCT CTAGAGCAGGTCATTTTGAGCCTCTCCATGGTGCTGCAGCTGTCCCTCCGCTGATACCTTCATCTCAGCATAAGCCAGAAGCTCTGCCTTCAAACACCAA ACCACTGCCTCCACCCCCAACTCAAACCGAAGAAGAGGAAGATCCAGCAATGAAGCCACAGTCTGTACTCACCAGAGTTAAGATGTTTGAAAACAAAAGA TCTGCATCCTTAGAGACCAAGAAGGATGTAAATGACACTGGCAGTTTTAAGCCTCCAGAAGTAGCATCTAAACCTTCAGGTGCTCCCATCATTGGTCCCA AACCCACTTCTCAGAATCAATTCAGTGAACATGACAAAACTCTGTACAGGATCCCAGAACCTCAAAAACCTCAACTGAAGCCACCTGAAGATATTGTTCG GTCCAATCATTATGACCCTGAAGAAGATGAAGAATATTATCGAAAACAGCTGTCATACTTTGACCGAAGAAGTTTTGAGAATAAGCCTCCTGCACACATT GCCGCCAGCCATCTCTCCGAGCCTGCAAAGCCAGCGCATTCTCAGAATCAATCAAATTTTTCTAGTTATTCTTCAAAGGGAAAGCCTCCTGAAGCTGATG GTGTGGATAGATCATTTGGCGAGAAACGCTATGAACCCATCCAGGCCACTCCCCCTCCTCCTCCATTGCCCTCGCAGTATGCCCAGCCATCTCAGCCTGT CACCAGCGCGTCTCTCCACATACATTCTAAGGGAGCACATGGTGAAGGTAATTCAGTGTCATTGGATTTTCAGAATTCCTTAGTGTCCAAACCAGACCCA CCTCCATCTCAGAATAAGCCAGCAACTTTCAGACCACCAAACCGAGAAGATACTGCTCAGGCAGCTTTCTATCCCCAGAAAAGTTTTCCAGATAAAGCCC CAGTTAATGGAACTGAACAGACTCAGAAAACAGTCACTCCAGCATACAATCGATTCACACCAAAACCATATACAAGTTCTGCCCGACCATTTGAACGCAA GTTTGAAAGTCCTAAATTCAATCACAATCTTCTGCCAAGTGAAACTGCACATAAACCTGACTTGTCTTCAAAAACTCCCACTTCTCCAAAAACTCTTGTG AAATCGCACAGTTTGGCACAGCCTCCTGAGTTTGACAGTGGAGTTGAAACTTTCTCTATCCATGCAGAGAAGCCTAAATATCAAATAAATAATATCAGCA CAGTGCCTAAAGCTATTCCTGTGAGTCCTTCAGCTGTGGAAGAGGATGAAGATGAAGATGGTCATACTGTGGTGGCCACAGCCCGAGGCATATTTAACAG CAATGGGGGCGTGCTGAGTTCCATAGAAACTGGTGTTAGTATAATTATCCCTCAAGGAGCCATTCCCGAAGGAGTTGAGCAGGAAATCTATTTCAAGGTC TGCCGGGACAACAGCATCCTTCCACCTTTAGATAAAGAGAAAGGTGAAACACTGCTGAGTCCTTTGGTGATGTGTGGTCCCCATGGCCTCAAGTTCCTGA AGCCTGTGGAGCTGCGCTTACCACACTGTGATCCTAAAACCTGGCAAAACAAGTGTCTTCCCGGAGATCCAAATTATCTCGTTGGAGCAAACTGTGTTTC TGTCCTTATTGACCACTTTTAACTCTTGAAATATAGGAACTTAAATAATGTGAAACTGGATTAAACTTAATCTAAATGGAACCACTCTATCAAGTATTAT ACCTTTTTTAGAGTTGATACTACAGTTTGTTAGTATGAGGCATTTGTTTGAACTGATAAAGATGAGTGAGCATGCCCCTGAACCATGGTCGGAAAACATG CTACACACTGCATGTTTGTGATTGACGGGACTGTTGGTATTGGCTAGAGGTTCAAAGATATTTTGCTTTGTGATTTTTGTAATTTTTTTATCGTCACTGC TTAACTTCACATATTGATTTCCGTTAAAATACCAGCCAGTAAATGGGGGTGCATTTGAGGTCTGTTCTTTCCAAAGTACACTGTTTCAAACTTTACTATG GCCCTGGCCTAGCATACGTACACATTTTATTTTATTATGCATGAAGTAATATGCACACATTTTTTAAATGCACCTGGAATATATAACCAGTGTTGTGGAT TTAACAGAAATGTACAGCAAGGAGATTTACAACTGGGGGAGGGTGAAGTGAAGACAATGACTTACTGTACATGAAAACACATTTTTCTTAGGGAAGGATA CAAAAGCATGTGAGACTGGTTCCATGGCCTCTTCAGATCTCTAACTTCACCATATTACCACAGACATACTAACCAGCAGAAATGCCTTACCCTCATGTTC TTAATTCTTAGCTCATTCTCCTTGTGTTACTAAGTTTTTATGGCTTTTGTGCATTATCTAGATACTGTATCATGACAAAGACTGAGTACGTTGTGCATTT GGTGGTTTCAGAAATGTGTTATCACCCAGAAGAAAATAGTGGTGTGATTTGGGGATATTTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTTTGACAA GGGGCAGTGGTGGTTTTCTGTTCTTTCTGGCTATGCATTTGAAAATTTTGATGTTTTAAGGATGCTTGTACATAATGCGTGCATACCACTTTTGTTCTTG GTTTGTAAATTAACTTTTATAAACTTTACCTTTTTTATACATAAACAAGACCACGTTTCTAAAGGCTACCTTTGTATTCTCTCCTGTACCTCTTGAGCCT TGAACTTTGACCTCTGCAGCAATAAAGCAGCGTTTCTATGACACATGCAAGGTCATTTTTTTTAAGAAAAAGGATGCACAGAGTTGTTACATTTTTAAGT GCTGCATTTAAAAGATACAGTTACTCAGAATTCTCTAGTTTGATTAAATTCTTGCAAAGTATCCCTACTGTAATTTGTGATACAATGCTGTGCCCTAAAG TGTATTTTTTTACTAATAGACAATTTATTATGGCACATCAGCACGATTTCTGTTTAGATAATACACCACTACATTCTGTTAATCATTAGGTGTGACTGAA TTTCTTTTGCCGTTATTAAAAATCTCAAATTTCTAAATCTCCAAAATAAAACTTTTTAAAATAAA

refseq_TJP1.F1 (forward primer)
refseq_TJP1.R1 (reverse primer)
Single exon skipping

Frame 0

RACSVGRAGRFAWPLSCRRRLSQRTPRSLAAAG SREVTWRSRLPRRRREATGAADGRATGRGRRGRA AKAAGGRVGGRARREVPVGRAPWRRPGRGGRFP DFCPS*IPSPWAGPFRPPPPVPRSLSGDVYLGC GVRSGRASAAEFRVRGASRGAGERQDVRQSCGRQ EHSNGGNSYMGTTYSDASQGSWIWIWNCNIWWT R*SSFSEWGNVNSDFRCAERRTS*RTATGK*PS CNG*RSFNG*C*TCFCCSATKEKWEKCKNYN*KE EESSNTSKSS*S*TSI***RR*L**GNT*SKKW PEWCG*QKE*EDLAEG*KCK*REELVPAVRQAV SGFQPAC*TY*SHTGEIPEK*RIWSSIGKPYIC* GNFTR*FGSKRWQYSRR*CCIEDKWYCDRKYVI DRCKDIDRKV*RQIKNGSSKR*TGYAIECP*SF *QHPLC*CL*ERRHFRNSVTGIRSFWSITR*ASP PQPVTIS*PAVRAF*SFQALAAAAKQWQSPE*R *RENF*TWGCLNSCKAC**SHT*NSGRSYS*KK *ETNTFSSRTKACVCPSWATRCGFTCQSI*WCPT *FNS*RWDSSAQHEIGKIQKRR*CGFAAGWWK* CWNICSWRSRR*PCSQGRLRGR*SNSQGKQRRF YKYHKRRSRPFPA*PP*RRRSDHIGSEEEGCLSS HCRIRCRRFFLY*NPF*I*KGISLWT*F*QRRG VPCCGYLVQWKTGLLACYSNW*KS*GGRTRHHP **EQS*AASQCTVYTSKNSRRRPC*LLEIQRSSQ LQEKSSKKQRGFVRSACSNKVSSL*KSGSSRSW ISEACNHFWTNS*CCQRKAGKRRTRYLSNCKE* TTRRWN*PT*LWHYSPAYNKANHRSRQTCFIRCN TKCS*SS*LCPVVSNCCIS*P*F*ARSKNNENE VMSRISEKCQEVIRAIS*TS*K*SPSFYNYN*L KFNE*WLVWCAERSNSTTAKPAGMGFRGKGGWCY K**P*FA**SSVLPVSSR**ILNV*HGQ*THF* L*RHRHRRRGLH*SRTR*NS***GWDSTGVCHY TVL*ACKRGLLWNAS*KPNISSLLTTSAATTNS* NRLPWI*ASLSTESRSFISSPLPFA*NKPSIIN LCC*S*CKFN*CQTGGAHPSSFHLLLTTS*FFK NTKY*GSSHNAKRSRTIIVVACRSNKGV*KGSIS RGNDEAEPCFETASR*SPRAQARQRA*SDL*TP TPIRRETSQQRPRAAHIQIRVLKLYGPVFSKL* TSSAIRRSRPHV*RTVVIL**QTALPISATF**S ALSRP*LQTASRRVLRTRVLSTF*RASPSVLRQ QTTLRTGT*SIRPAARRAASSWV*HTW*TQTGS PAPPFSRAQACRVQAVF*AIFTQLRASTTPRIYL *SRSF*ASPWCCSCPSADTFISA*ARSSAFKHQ TTASTPNSNRRRGRSSNEATVCTHQS*DV*KQK ICILRDQEGCK*HWQF*ASRSSI*TFRCSHHWSQ THFSESIQ*T*QNSVQDPRTSKTSTEAT*RYCS VQSL*P*RR*RILSKTAVIL*PKKF*E*ASCTH CRQPSLRACKASAFSESIKFF*LFFKGKAS*S*W CG*IIWRETL*THPGHSPSSSIALAVCPAISAC HQRVSPHTF*GSTW*R*FSVIGFSEFLSVQTRP TSISE*ASNFQTTKPRRYCSGSFLSPEKFSR*SP S*WN*TDSENSHSSIQSIHTKTIYKFCPTI*TQ V*KS*IQSQSSAK*NCT*T*LVFKNSHFSKNSC EIAQFGTAS*V*QWS*NFLYPCREA*ISNK*YQH SA*SYSCESFSCGRG*R*RWSYCGGHSPRHI*Q QWGRAEFHRNWC*YNYPSRSHSRRS*AGNLFQG LPGQQHPSTFR*RER*NTAESFGDVWSPWPQVPE ACGAALTTL*S*NLAKQVSSRRSKLSRWSKLCF CPY*PLLTLEI*ELK*CETGLNLI*MEPLYQVL YLF*S*YYSLLV*GICLN**R*VSMPLNHGRKTC YTLHVCD*RDCWYWLEVQRYFAL*FL*FFYRHC LTSHIDFR*NTSQ*MGVHLRSVLSKVHCFKLYY GPGLAYVHILFYYA*SNMHTFFKCTWNI*PVLWI *QKCTARRFTTGGG*SEDNDLLYMKTHFS*GRI QKHVRLVPWPLQISNFTILPQTY*PAEMPYPHV LNS*LILLVLLSFYGFCALSRYCIMTKTEYVVHL VVSEMCYHPEENSGVIWGYFFLFFSFLFFFF*Q GAVVVFCSFWLCI*KF*CFKDACT*CVHTTFVL GL*INFYKLYLFYT*TRPRF*RLPLYSLLYLLSL EL*PLQQ*SSVSMTHARSFFLRKRMHRVVTFLS AAFKRYSYSEFSSLIKFLQSIPTVICDTMLCPK VYFFTNRQFIMAHQHDFCLDNTPLHSVNH*V*LN FFCRY*KSQISKSPK*NFLK*

Frame 1

GHAQWAGPAGLRGR*VAGAG*ASGRRVPWRPPV PGKLRGEAGFRGDAGRPRVLLTGGRPGEADVAG LRKLREAEWVAALGGRCRSGAPRGEDPGGAGASR TFVRVEFPPPGPGPSGRPRPCPARSREMFIWAV A*GAGGPAPRSFGSEEPRAALERDKMSARAAAA KSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR DNPHFQSGETSIVISDVLKGGPAEGQLQENDRV AMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRR KKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSG RSGVVNRRSEKIWPRDRSASRERSLSPRSDRRS VASSQPAKPTKVTLVKSRKNEEYGLRLASHIFV KEISQDSLAARDGNIQEGDVVLKINGTVTENMSL TDAKTLIERSKGKLKMVVQRDERATLLNVPDLS DSIHSANASERDDISEIQSLASDHSGRSHDRPP RRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD EERISKPGAVSTPVKHADDHTPKTVEEVTVERN EKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVL PNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND VGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDF TNIIREEAVLFLLDLPKGEEVTILAQKKKDVYR RIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIP NKNRAEQLASVQYTLPKTAGGDRADFWRFRGLR SSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG FLRPVTIFGPIADVAREKLAREEPDIYQIAKSE PRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDV TPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMR LCPESRKSARKLYERSHKLRKNNHHLFTTTINL NSMNDGWYGALKEAIQQQQNQLVWVSEGKADGA TSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD YEDTDTEGGAYTDQELDETLNDEVGTPPESAIT RSSEPVREDSSGMHHENQTYPPYSPQAQPQPIH RIDSPGFKPASQQKAEASSPVPYLSPETNPASST SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLR TPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPY PEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQ LPYVEKQASRDLEQPTYRYESSSYTDQFSRNYE HRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDN QHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDS RPRYEQAPRASALRHEEQPAPGYDTHGRLRPEA QPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFT SRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKR SASLETKKDVNDTGSFKPPEVASKPSGAPIIGP KPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVR SNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHI AASHLSEPAKPAHSQNQSNFSSYSSKGKPPEAD GVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPV TSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDP PPSQNKPATFRPPNREDTAQAAFYPQKSFPDKA PVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLV KSHSLAQPPEFDSGVETFSIHAEKPKYQINNIS TVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNS NGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKV CRDNSILPPLDKEKGETLLSPLVMCGPHGLKFL KPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVS VLIDHF*LLKYRNLNNVKLD*T*SKWNHSIKYY TFFRVDTTVC*YEAFV*TDKDE*ACP*TMVGKH ATHCMFVIDGTVGIG*RFKDILLCDFCNFFIVTA *LHILISVKIPASKWGCI*GLFFPKYTVSNFTM ALA*HTYTFYFIMHEVICTHFLNAPGIYNQCCG FNRNVQQGDLQLGEGEVKTMTYCT*KHIFLREGY KSM*DWFHGLFRSLTSPYYHRHTNQQKCLTLMF LILSSFSLCY*VFMAFVHYLDTVS*QRLSTLCI WWFQKCVITQKKIVV*FGDIFFFSFLFFFFFFDK GQWWFSVLSGYAFENFDVLRMLVHNACIPLLFL VCKLTFINFTFFIHKQDHVSKGYLCILSCTS*A LNFDLCSNKAAFL*HMQGHFF*EKGCTELLHF*V LHLKDTVTQNSLV*LNSCKVSLL*FVIQCCALK CIFLLIDNLLWHISTISV*IIHHYILLIIRCD* ISFAVIKNLKFLNLQNKTF*NK

Frame 2

GMLSGPGRQVCVAAELPAPAEPADAAFLGGRRF PGSYVAKPASEETPGGHGCC*RAGDRARPTWPG CESCGRPSGWPRSEGGAGRARPVEKTRAGRALP GLLSELNSLPLGRALPAAPARAPLALGRCLFGLW REERAGQRRGVSGPRSLARRWRETRCPPELRPP RAQQWRKQLYGNNIQ*RFTGLLDLDLELQYLVD EIILIFRVGKRQ**FQMC*KEDQLKDSYRKMTEL QWLTEFQWIMLNMLLLFSN*GKVGKMQKLQLEG RRKFKYQ*VVLILNQYLIMKKIVMMRKYMIQEV AGVVWLTEGVRRFGRGIEVQVERGACPRGQTGGQ WLPASLLNLLKSHW*NPGKMKNMVFDWQAIYLL RKFHKIVWQQEMAIFKKVMLY*R*MVL*QKICH *QMQRH**KGLKAN*KW*FKEMNGLRY*MSLIFL TASTLLMPLRETTFQKFSHWHQIILVDHTIGLP AAAGHDLLTSGQSLLIIPGTRRSSQAMAVSGVE MKREFLNLGLSQLL*SMLMITHLKQWKKLQLKEM RNKHLLFQNQSLCMPKLGNQMWIYLSVHLMVSY LIQLMKMGFFGPA*NW*NSEKEIVWVCGWLVEM MLEYL*LAF*KIALQPRKA*RKVIKFSG*TT*IL QIS*EKKPSFSCLTSLKEKK*PYWLRRRRMFIV AL*NQM*EILSILEPILNMKRNLPMDLVLTKER CSVLWIPCTMENWALGLLFELVKIIRR*NEASSL IRTELSS*PVYSIHFQKQQAETVLTSGDSEVFA APREIFEKAERICPLSLFKQSFQLMKEWFFEKL DF*GL*PFLDQ*LMLPEKSWQEKNQIFIKLQRVN HETLELTNVALALFACIQ*SKS*IKTNMLY*M* HQMQLIVLTMPSGIQLLYFLTLILSKE*KQ*E* GYVQNLGKVPGSYTSDLINFVKIITIFLQLQLT* IQ*MMVGMVR*KKQFNNSKTSWYGFPRERRMVL QVMTLICMMIVCPTCQLQVVNTQCIARTVDTLL TMKTQTQKAGPTLIKN*MKLLMMRLGLHRSLPLH GPLSL*ERTPLECIMKTKHILLTHHKRSHNQFI E*TPLDLSQPLNRKQKLHLQSLTFRLKQTQHHQ PLLLIIM*I*LMSDWRSPPQLLPPLTHHKLIL*E HQVLRQLT*C*EIKNHHCRRM*IQQRCIERIHI PRK**GRTMF*NSQPLVTQGTGQTKSLI*PMNP NSHT*RNKPAETSSSPHTDTSPQAIRTSFLETMN IVCDTKIASPCMKNSGHIMMTNSPTHLGHLLII STLKTLTPDSIPKSPQNEGTFHVLKSQPLCLTT ADHVTNRHLEHPPCGTKSSQLLGMTHMVDSDRKP SPTLQQGPSLQSPSSILSNIHAVTSKYHPKDLP LEQVILSLSMVLQLSLR*YLHLSISQKLCLQTP NHCLHPQLKPKKRKIQQ*SHSLYSPELRCLKTKD LHP*RPRRM*MTLAVLSLQK*HLNLQVLPSLVP NPLLRINSVNMTKLCTGSQNLKNLN*SHLKILF GPIIMTLKKMKNIIENSCHTLTEEVLRISLLHTL PPAISPSLQSQRILRINQIFLVILQRESLLKLM VWIDHLARNAMNPSRPLPLLLHCPRSMPSHLSL SPARLSTYILREHMVKVIQCHWIFRIP*CPNQTH LHLRISQQLSDHQTEKILLRQLSIPRKVFQIKP QLMELNRLRKQSLQHTIDSHQNHIQVLPDHLNA SLKVLNSITIFCQVKLHINLTCLQKLPLLQKLL* NRTVWHSLLSLTVELKLSLSMQRSLNIK*IISA QCLKLFL*VLQLWKRMKMKMVILWWPQPEAYLT AMGAC*VP*KLVLV*LSLKEPFPKELSRKSISRS AGTTASFHL*IKRKVKHC*VLW*CVVPMASSS* SLWSCAYHTVILKPGKTSVFPEIQIISLEQTVF LSLLTTFNS*NIGT*IM*NWIKLNLNGTTLSSII PFLELILQFVSMRHLFELIKMSEHAPEPWSENM LHTACL*LTGLLVLARGSKIFCFVIFVIFLSSL LNFTY*FPLKYQPVNGGAFEVCSFQSTLFQTLLW PWPSIRTHFILLCMK*YAHIF*MHLEYITSVVD LTEMYSKEIYNWGRVK*RQ*LTVHENTFFLGKD TKACETGSMASSDL*LHHITTDILTSRNALPSCS *FLAHSPCVTKFLWLLCII*ILYHDKD*VRCAF GGFRNVLSPRRK*WCDLGIFFSFLFFSFFFFLT RGSGGFLFFLAMHLKILMF*GCLYIMRAYHFCSW FVN*LL*TLPFLYINKTTFLKATFVFSPVPLEP *TLTSAAIKQRFYDTCKVIFFKKKDAQSCYIFK CCI*KIQLLRIL*FD*ILAKYPYCNL*YNAVP*S VFFY**TIYYGTSARFLFR*YTTTFC*SLGVTE FLLPLLKISNF*ISKIKLFKI