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Sequences

Sequence NM_003678

CTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTACTCCCGGTGCCAGGTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAA
TCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGAAGGTAAATACTACA
GTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGATCCAAGA
CCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTA
GCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAACCTGTTGTATGAGGTGA
TGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACC
AGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAG
TACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGC
AGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCT
CTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCA
GAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCA
AGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAA
CATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTG
TATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAG
GTCACCCCTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCA
CATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACC
AGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAG
ACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGTGTTGAACCC
TGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAA
GTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGG
AGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATT
TAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTT
CTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGG
TGGCTTTGCAGTCTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAA
AAAGATTCCAATTCTGCAGAGAGATGCTCA
  • refseq_THOC5.F2 (forward primer)
  • refseq_THOC5.R2 (reverse primer)
  • Single exon skipping

Frame 0

LYGARASFAPPPAVAYSRCQVLGAVRRNNHVIR
IEQKTEAQSDPKRWSPS*RKAESI*HRAGR*ILQ
*GGRGGSAGPWQRL*VIQVHLPGATEADG*DPR
PEEQGWQGCGNRNRRTEDPELCAFHDSKEA*PI
SPHQVEERKRSDPRG*AESRCLSSAAPEPVV*GD
APTEGDHQMFGV*VKA*RN*SGQFRGVL*GGST
RYQQGRSHHGRPSPANTGTSGLGAGAAEKAGRE
VPRVPI*QGEDSQGD*GEEGVPEQPPAPPQQHHA
GFPSGAGVPVYAIRPGSQAV*DSQTPAASPLCP
LCSGHCVWAGL**DVICGNRRQCG*SQGSVQTS
RGLPR*RE*LRCRGGADYEAPETHTGGSVGRQTQ
GDAEEAPTVCHARPEVQR*QCASPDFLLPHEPQ
HHDSKSQSDNCHGADHPHQCR*LAVS*LSPELL
VSWGSWKENSESSQSVSV**SWHPDFERLCT*AR
SPLFVGAEAGWPPLPQRAAPANSDC*PLAERQP
HGDHHETSEDQGAVPPGPPQTVCIPRTWHCASY
Q*LPVPLPCQGCLSPGEMGDSCP*GLHGAALHQR
HCGCGTGWGHQSLLHGAHRKGHSQTAGRCGVEP
WLLLHPTCFPALFELERGENQQQR*QHSGHGGR
SQCVLQGAVWPLAQPPAVDQPAAAAVCAAGCLPG
DREP*RQCGGAQGISPGEDVSAALQGS*QDEAI
*IQPSSGILQPSLISRADRCFPQGLTLSTGLLL
SALAHM*LLIFSKDTSQLKSVT*PVAFVCGSWQG
GFAVWKGRWEL*HSVKKHL*RDFFSAANKSRVE
KDSNSAERCS

Frame 1

SMVRGQALLRLRQWLTPGARFLEL*GGTTMSSE
SSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYY
SEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQD
LKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRL
AHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEV
MHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPP
DISKAEVTMGDPHQQTLARLDWELEQRKRLAEK
YRECLSNKEKILKEIEVKKEYLSSLQPRLNSIM
QASLPVQEYLFMPFDQAHKQYETARHLPPPLYVL
FVQATAYGQACDKTLSVAIEGSVDEAKALFKPP
EDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKR
KEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLN
IMTVKAKVTTAMELITPISAGDLLSPDSVLSCL
YPGDHGKKTPNPANQYQFDKVGILTLSDYVLEL
GHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASH
METTMKLLKTRVQSRLALHKQFASLEHGIVPVT
SDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTK
DIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNP
GYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGE
VNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYL
ETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPF
KYNHPQGFFSHR*SPAQTVVSPKASP*ALGFCF
LLWPTCDS*YSPKTPAN*KASPDQWPLSVVPGK
VALQSGRAGGSCDTV*KSICRETFSQQPIKAEWK
KIPILQRDA

Frame 2

LWCAGKLCSASGSGLLPVPGSWSCEEEQPCHQN
RAKNGSPK*SEAMEPQLKESGIDLTPSRKVNTT
VRRPRWICGTLAETMSYTSTPARSYRG*WLRSK
T*RAGVARMWQ*K*KNGGSRAVCIS*L*RSLTD*
PTSG*RKEEIRPTRLSRK*MPIICSSRTCCMR*
CTYRRRSPNVWSLSQSMKKLIWSV*RSFIRRLH
QISARPKSPWETLTSKHWHVWTGSWSSGKGWQRS
TESAYLTRRRFSRRLR*RRST*AASSPASTASC
RLPFRCRSTCLCHSTRLTSSMRQPDTCRLPSMS
SLFRPLRMGRPVIRRYLWQSKAVWMKPRLCSNLQ
RTPKMTRVTQMPRRSRLRSAGDPHWGFSWTTNA
RRC*RGTHCLSCST*SAKMTVCFT*LSTTS*TS
TS*Q*KPK*QLPWS*SPPSVQVTCCLLTQS*VAC
ILGIMERKLRIQPISISLIKLAS*L*ATMYLS*
VTPICGCRSWVASTSPKSSPSKQ*LLTTR*APA
TWRPP*NF*RPGCSPAWPSTNSLHP*NMALCQLP
VIASTSSLPRLSLAW*NG*QLPMRITWSCTSPK
TLWMRDWLGTPISTTWRSSKGAQPNCRPLWC*T
LATPPSHLFSSSV*TGKGRKPTATMTTFGPWRAK
SMCATRSCVALGPATSC*PTSCSGCVCCWMFTW
RPRAMTTVWRGPRNFPRRRCVCGSSGVLAG*SH
LNTTILRDSSAIADLPRRPLFPPRPHPEHWASAF
CSGPHVTLDILQRHQPIKKRHLTSGLCLWFLAR
WLCSLEGQVGAVTQCEKAFVERLFLSSQ*KQSG
KRFQFCREML

Sequence NM_001002877

CTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTACTCCCGGTGCCAGGTTCTTGGAGCTGTGAGGTGTTCAGCATTATTTAAGATCA
CCTATGCATCATCTGAAGCCACAGTCCCAGGTCATCTTCATCACCTTCCCCAGTGGAATGCCTCCTGTGTTAAAGCCCACAACAACCCCTGTGGAGGAAC
AACCATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAG
GAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGACTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGA
TGGCTGAGATCCAAGACCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAGAGCTGTGTGCATTTCATGACTCTAAA
GAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAAAGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGCAGCTCCAGAAC
CTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAAGTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTT
ATAAGGAGGCTCCACCAGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGGCACGTCTGGACTGGGAGCTGGAGCAGCGGAA
AAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGC
CTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGC
CTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAAGGC
TCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAG
TTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACT
ACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTC
AGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGAC
TATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACT
CGCTGAGCGCCAGCCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGG
CATTGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAG
CTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCG
CTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACATTCG
GGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTG
CTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTA
GCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGTTTCCCCCAAGGCCTCACCCTGAGC
ACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCT
GTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAGCTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAA
TAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAGAGATGCTCA
  • refseq_THOC5.F2 (forward primer)
  • refseq_THOC5.R2 (reverse primer)
  • Single exon skipping

Frame 0

LYGARASFAPPPAVAYSRCQVLGAVRCSALFKI
TYASSEATVPGHLHHLPQWNASCVKAHNNPCGGT
TMSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQ
EGKYYSEEAEVDLRDPGRDYELYKYTCQELQRL
MAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLK
KLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQN
LLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEF
YKEAPPDISKAEVTMGDPHQQTLARLDWELEQRK
RLAEKYRECLSNKEKILKEIEVKKEYLSSLQPR
LNSIMQASLPVQEYLFMPFDQAHKQYETARHLP
PPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKA
LFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQ
LDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFY
YLMNLNIMTVKAKVTTAMELITPISAGDLLSPDS
VLSCLYPGDHGKKTPNPANQYQFDKVGILTLSD
YVLELGHPYLWVQKLGGLHFPKEQPQQTVIADH
SLSASHMETTMKLLKTRVQSRLALHKQFASLEHG
IVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYME
LHFTKDIVDAGLAGDTNLYYMALIERGTAKLQA
AVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIR
AMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVL
LDVYLETESHDDSVEGPKEFPQEKMCLRLFRGP
SRMKPFKYNHPQGFFSHR*SPAQTVVSPKASP*A
LGFCFLLWPTCDS*YSPKTPAN*KASPDQWPLS
VVPGKVALQSGRAGGSCDTV*KSICRETFSQQP
IKAEWKKIPILQRDA

Frame 1

SMVRGQALLRLRQWLTPGARFLEL*GVQHYLRS
PMHHLKPQSQVIFITFPSGMPPVLKPTTTPVEE
QPCHQNRAKNGSPK*SEAMEPQLKESGIDLTPSR
KVNTTVRRPRWICGTLAETMSYTSTPARSYRG*
WLRSKT*RAGVARMWQ*K*KNGGSRAVCIS*L*
RSLTD*PTSG*RKEEIRPTRLSRK*MPIICSSRT
CCMR*CTYRRRSPNVWSLSQSMKKLIWSV*RSF
IRRLHQISARPKSPWETLTSKHWHVWTGSWSSG
KGWQRSTESAYLTRRRFSRRLR*RRST*AASSPA
STASCRLPFRCRSTCLCHSTRLTSSMRQPDTCR
LPSMSSLFRPLRMGRPVIRRYLWQSKAVWMKPR
LCSNLQRTPKMTRVTQMPRRSRLRSAGDPHWGFS
WTTNARRC*RGTHCLSCST*SAKMTVCFT*LST
TS*TSTS*Q*KPK*QLPWS*SPPSVQVTCCLLT
QS*VACILGIMERKLRIQPISISLIKLAS*L*AT
MYLS*VTPICGCRSWVASTSPKSSPSKQ*LLTT
R*APATWRPP*NF*RPGCSPAWPSTNSLHP*NM
ALCQLPVIASTSSLPRLSLAW*NG*QLPMRITWS
CTSPKTLWMRDWLGTPISTTWRSSKGAQPNCRP
LWC*TLATPPSHLFSSSV*TGKGRKPTATMTTF
GPWRAKSMCATRSCVALGPATSC*PTSCSGCVCC
WMFTWRPRAMTTVWRGPRNFPRRRCVCGSSGVL
AG*SHLNTTILRDSSAIADLPRRPLFPPRPHPE
HWASAFCSGPHVTLDILQRHQPIKKRHLTSGLCL
WFLARWLCSLEGQVGAVTQCEKAFVERLFLSSQ
*KQSGKRFQFCREML

Frame 2

LWCAGKLCSASGSGLLPVPGSWSCEVFSII*DH
LCII*SHSPRSSSSPSPVECLLC*SPQQPLWRN
NHVIRIEQKTEAQSDPKRWSPS*RKAESI*HRA
GR*ILQ*GGRGGSAGPWQRL*VIQVHLPGATEAD
G*DPRPEEQGWQGCGNRNRRTEDPELCAFHDSK
EA*PISPHQVEERKRSDPRG*AESRCLSSAAPE
PVV*GDAPTEGDHQMFGV*VKA*RN*SGQFRGVL
*GGSTRYQQGRSHHGRPSPANTGTSGLGAGAAE
KAGREVPRVPI*QGEDSQGD*GEEGVPEQPPAP
PQQHHAGFPSGAGVPVYAIRPGSQAV*DSQTPAA
SPLCPLCSGHCVWAGL**DVICGNRRQCG*SQG
SVQTSRGLPR*RE*LRCRGGADYEAPETHTGGS
VGRQTQGDAEEAPTVCHARPEVQR*QCASPDFLL
PHEPQHHDSKSQSDNCHGADHPHQCR*LAVS*L
SPELLVSWGSWKENSESSQSVSV**SWHPDFER
LCT*ARSPLFVGAEAGWPPLPQRAAPANSDC*PL
AERQPHGDHHETSEDQGAVPPGPPQTVCIPRTW
HCASYQ*LPVPLPCQGCLSPGEMGDSCP*GLHG
AALHQRHCGCGTGWGHQSLLHGAHRKGHSQTAGR
CGVEPWLLLHPTCFPALFELERGENQQQR*QHS
GHGGRSQCVLQGAVWPLAQPPAVDQPAAAAVCA
AGCLPGDREP*RQCGGAQGISPGEDVSAALQGS*
QDEAI*IQPSSGILQPSLISRADRCFPQGLTLS
TGLLLSALAHM*LLIFSKDTSQLKSVT*PVAFV
CGSWQGGFAVWKGRWEL*HSVKKHL*RDFFSAAN
KSRVEKDSNSAERCS

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