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Sequences

Sequence NM_012309

ATGATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTA TTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACC AACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGGTT AACAATGAGAATGTTGTCAAAGTCGGCCACAGGCAGGTGGTGAACATGATCCGGCAGGGAGGGAATCACCTGGTCCTTAAGGTGGTCACGGTGACCAGGA ATCTGGACCCCGACGACACCGCCAGGAAGAAAGCTCCCCCGCCTCCAAAGCGGGCACCGACCACAGCCCTCACCCTGCGCTCCAAGTCCATGACCTCGGA GCTGGAGGAGCTCGTGGATAAAGATAAACCCGAGGAGATAGTCCCGGCCTCCAAGCCCTCCCGCGCTGCTGAGAACATGGCTGTGGAACCGAGGGTGGCG ACCATCAAGCAGCGGCCCAGCAGCCGGTGCTTCCCGGCGGGCTCAGACATGAACTCTGTGTACGAACGCCAAGGAATCGCCGTGATGACGCCCACTGTTC CTGGGAGCCCAAAAGCCCCGTTTCTGGGCATCCCTCGAGGTACGATGCGAAGGCAGAAATCAATAGACAGCAGAATCTTTCTATCAGGAATAACAGAGGA AGAGCGGCAGTTTCTGGCTCCTCCAATGCTGAAGTTCACCAGAAGCCTGTCCATGCCGGACACCTCTGAGGACATCCCCCCTCCACCGCAGTCTGTGCCC CCGTCCCCACCACCACCTTCCCCAACCACTTACAACTGCCCCAAGTCCCCAACTCCAAGAGTCTACGGGACGATTAAGCCTGCGTTCAATCAGAATTCTG CCGCCAAGGTGTCCCCCGCCACCAGGTCCGACACCGTGGCCACCATGATGAGGGAGAAGGGGATGTACTTCAGGAGAGAGCTGGACCGCTACTCCTTGGA CTCTGAAGACCTCTACAGTCGGAATGCCGGCCCGCAAGCCAACTTCCGCAACAAGAGAGGCCAGATGCCAGAAAACCCATACTCAGAGGTGGGGAAGATC GCCAGCAAAGCCGTCTACGTCCCCGCCAAGCCCGCCAGGCGGAAGGGGATGCTGGTGAAGCAGTCCAACGTGGAGGACAGCCCCGAGAAGACGTGCTCCA TCCCTATCCCGACCATCATCGTGAAGGAGCCGTCCACCAGCAGCAGCGGCAAGAGCAGCCAGGGCAGCAGCATGGAGATCGACCCCCAGGCCCCGGAGCC ACCGAGCCAGCTGCGGCCTGACGAAAGCCTGACCGTCAGCAGCCCCTTTGCCGCCGCCATCGCCGGAGCCGTCCGCGACCGTGAGAAGCGGCTGGAAGCC AGGAGGAACTCCCCGGCCTTCCTCTCCACAGACCTGGGGGATGAGGATGTGGGCCTGGGGCCACCCGCCCCCAGGACGCGGCCCTCCATGTTCCCCGAGG AGGGGGATTTTGCTGACGAGGACAGCGCTGAGCAGCTGTCATCCCCCATGCCGAGTGCCACGCCCAGGGAGCCCGAAAACCATTTCGTGGGTGGCGCCGA GGCCAGTGCTCCGGGTGAGGCTGGGAGGCCGCTGAATTCCACGTCCAAAGCCCAGGGGCCCGAGAGCAGCCCAGCAGTGCCCTCCGCGAGCAGCGGCACA GCCGGCCCCGGGAATTATGTCCACCCACTCACAGGGCGGCTGCTTGATCCCAGCTCCCCGCTGGCCCTGGCACTCTCCGCAAGGGACCGAGCCATGAAGG AGTCTCAACAGGGACCCAAAGGGGAGGCCCCCAAGGCCGACCTCAACAAACCTCTTTACATTGATACCAAAATGCGGCCCAGCCTGGATGCCGGCTTCCC TACGGTCACCAGGCAGAACACCCGGGGACCCCTGAGGCGGCAGGAGACGGAGAACAAGTACGAGACCGACCTGGGCCGAGACCGGAAAGGCGATGACAAG AAGAACATGCTGATCGACATCATGGACACGTCCCAGCAGAAGTCGGCTGGCCTGCTGATGGTGCACACCGTGGACGCCACTAAGCTGGACAACGCCCTGC AGGAAGAGGACGAGAAGGCAGAGGTGGAGATGAAGCCAGACAGCTCGCCGTCCGAGGTGCCAGAAGGTGTTTCCGAAACCGAAGGTGCTTTACAGATCTC CGCTGCCCCCGAGCCCACCACCGTGCCCGGCAGAACCATCGTCGCGGTGGGCTCCATGGAAGAGGCGGTGATTTTGCCATTCCGCATCCCTCCTCCCCCT CTGGCATCCGTGGACTTGGATGAGGATTTTATTTTTACAGAGCCATTGCCTCCTCCCCTGGAATTTGCAAATAGTTTTGATATCCCCGATGACCGGGCAG CTTCTGTCCCGGCTCTCTCAGACTTAGTGAAGCAGAAGAAAAGCGACACCCCTCAGTCCCCTTCGTTGAACTCCAGCCAACCAACCAACTCTGCAGACAG CAAGAAGCCAGCCAGTCTTTCAAACTGTCTGCCTGCCTCATTCCTGCCACCCCCTGAAAGCTTTGACGCCGTCGCCGACTCTGGGATCGAGGAGGTGGAC AGCCGGAGTAGCAGCGACCACCACCTCGAGACGACCAGCACTATCTCCACCGTGTCTAGCATCTCCACCCTGTCTTCCGAAGGTGGAGAGAATGTGGACA CCTGCACAGTCTATGCAGATGGGCAAGCATTTATGGTTGACAAACCCCCAGTACCTCCTAAGCCAAAAATGAAGCCCATCATTCACAAAAGCAATGCACT TTATCAAGACGCGCTCGTGGAAGAAGATGTAGATAGCTTTGTTATCCCCCCGCCCGCTCCCCCGCCCCCGCCGGGCAGTGCCCAGCCTGGGATGGCCAAG GTTCTCCAGCCAAGGACCTCCAAGTTGTGGGGCGACGTCACAGAGATCAAAAGCCCGATTCTCTCAGGCCCAAAGGCAAACGTTATTAGTGAATTGAACT CTATCCTACAGCAAATGAACCGAGAGAAATTGGCAAAGCCGGGGGAAGGACTGGATTCACCAATGGGAGCCAAGTCCGCCAGCCTCGCTCCAAGAAGCCC GGAGATCATGAGCACCATCTCAGGTACACGGAGCACGACGGTCACCTTCACTGTTCGCCCCGGCACCTCCCAGCCCATCACCCTGCAGAGCCGGCCCCCC GACTATGAAAGCAGGACCTCAGGAACAAGACGTGCCCCAAGCCCTGTGGTCTCGCCAACAGAGATGAACAAAGAGACCCTGCCCGCCCCCCTGTCTGCTG CCACCGCCTCTCCTTCTCCCGCTCTCTCAGATGTCTTTAGCCTTCCAAGCCAGCCCCCTTCTGGGGATCTATTTGGCTTGAACCCAGCGGGACGCAGTAG GTCGCCATCCCCCTCGATACTGCAACAGCCAATCTCAAATAAGCCTTTTACAACTAAACCTGTCCACCTGTGGACTAAACCAGATGTGGCCGATTGGCTG GAAAGTCTAAACTTGGGTGAACATAAAGAGGCCTTCATGGACAATGAGATCGATGGCAGTCACTTACCAAACCTGCAGAAGGAGGACCTCATCGATCTTG GGGTAACTCGAGTCGGGCACAGAATGAACATAGAAAGGGCTTTGAAACAGCTGCTGGACAGATAAGGACGGCTGCTCTCCACCTCGCAGACTGCTCTTGT TATAAGTAGAGATGGGCTCGTGCTGAAACATCTGAATGCCAAGCGAAGTCTGTGAGCATCAACCCCACTCCATGGGTTTGTCTCCTGGTACCCAAAGAAA TACTGAGTTGTGTCCACAACATGGCTGGGTCTTCAGACCCCTGGCTCACCATGTGGGTGTCTTGGGCAGTTTCTATCACACATGGGACAAGGGGAGGGAG TTTTTCTAACATGGAAAAAGATTCTCAGCCTGCCGCCCAGCATGCAGGTGGCCTCGCTTTGCCGGGTCCGAGAGGCTCCCCGTCAATTTTGCACGGGATC CTAGCTCTTGTAGGCAGACACCAGTGCACTCTAGATACCTCCTGAGACCTCCGTCCTCTGCTTTCCGGGCAGCTCTCACCACCCCAGGCCCCGGCATGAG GCCTTTCCTCAGTCCTGTGGCCTCTCAGAGGACACCTGATGCTCACCTGCCCCTCTTTCTCCTGCACTTGGCTTGCAGTGAGATGCTCCCAGATGCATTT GTCCAGTGCCCCATCATGGGCCTGAAAGGCAGAGAAACTTTTTCCTACACAGATTCTTTTCCCCATCTCCTCCTGTGGTTTGCATCCATGGCTCTTTGGC CATGAGGTTCCTGGCAGTGCTGGGAGTTTGGATGGGATCGTGCCCAGCTTTGCTTAGCTTTCTTTATTTCTGCAAATCTGTTAGCATAATTCCAAGGTGG CCAAGCAGATGTCACATGGAGTTAGTCAAAGCACAAAGTCACGATTCCACAATGGAGGGGAGACCTGGCCAAGGGAGCCAGCCAGCGTGCAACTGCCCAA GCTCCAGGTCTCCAGGACAAGAGCAGTTGTCTGCCATGAGCACCCATCCAGGATGGAGAATAAGGGCTTCTCTGCCTCTCAGAATTCTTTTTAATTGAAG ATGTCTTGAGCTCTGCAAAGATCAGAGCAGGTGAGCATCCACTTTGACATGAAGGACAAGAAGACGCATGGCTCATGGCGGGCACATGCGGCTGCCAGTG AGACAGCGTCTCCTCTGGGAGCTGGGCGGGCACAGCATCCTCAGTTCTGTGCCCAGCCAAGGGTGAGCATCTCTGCTGAGACAGTCCTTTTGCTCTCGGA GGCCAGGGAAGATGGTACTTAGAGGCTTTTCCCCTATCGCTCTGGGTGTCTAGGAATCCCACCAGCTTGTCTTAACAGTACAACAGCTTCTTTGAGGACC CAGTGGGTATGGAGTATAGACAGAACCCAGGGTTGAGAACAGAAGGTGGGCGGCAGGATCAGAGTGAAAGCAGAGGCGTGAGGAGAGGAAAGCAGGGAGG TCTCCTGGGCTGCCAGGTCAGCCTCTCTGGCAAGGCTTTCTTGAGCCCCGCCCCTTTCTTTCCCCGGAGTCCCTCCACCCCATAACAATACCTCGAATTT CCAAAAGAGGTCACCAGATGCACATGGGCCGCAAAACACACAGTCAGGCTTCCAGCACATTCTCCCCCATTTGGAGGATACTCGAATGTCAGGTTTTTGG TTTTATTATTATTTCAGAACTAGCTCAGCCCATCTCTAATTATAAAACATGGTTTTGTTTTTTTTTTTTCCTTTTTTTCTTGATTAGGTCTGGAACAGCT CTAGAATGAACACATAAAATTTAGCAATTTAAAATCTTTCTTTACTGCAAGTTTAAATAGTTGTACAGATAGTTTATAAGCACAATATTTTAAGAAAAAA AAGTGGCTGGTCTACTAGGCAGCCTTTGTGCCACTTCAGTGCTAGAAAGTTAAAGAAAAAAAAACTTTTGTGATTTAATAATACTATTTCTGTGGAATAA TTATAAAAGTATGACCTTTTTAAATCAACCTTATTTGGATGCATCTGAACCAGCAGAGCTGTGTTATATTTTCTATCTTTGCTAGAACTTCGTCATTGAA GGACAATTTCTTCAAAGTGGTTACAATTCATAATGCAGCAGTTTCTCCAAAAACAAAAACAAAACACACACCACACACACGCGCTTTTCCAGTCACACAC CCCTGATGTTGGAACCAAGTTTTTGGACCTTCTGTTCCAAAACCTTTTGCAGGTCAATCTTTGTATTTGAAATGATCCAATCCAACTTGAAGTCAATTGA ATATTAAGGCGCTTTACTTCCGTGTGCTTTCAGTTTTTCCATCATGAGATGAATGAGCATTACTCTAGATAAATTTCAAGACAGGATACTACAGGTGGCC TGCTGAGGCTGCCCCATATTTTAGAAAATGTAAAAATGGTGGTTTGGCCATTAATTTGTCTTCCATTTGATGATACCGCAAAATTCCGTGAGTCCATTCC TTTGGCATGGCACTTTCCCTGGGCCTACAGTTGGTATTACCTCTGTGCTCAGTGCCAGGCAAAACACTAGCTCAAAGGAGAGTCAAGGAAACCGCTGGCA GACGATAACCAGTCGAAACTCGTGACTTCGGTTTGTTGAACTTTGGCAGCCAGTTGGTGAGGGCCAGATGTTATTCCCTTTCTTAAAGATACTCCAAGCC ACATGCCACTAACCACAAGCAAGCTGGCTGCAAGACTAAAGAGCTGATAACATAGTTTATTTTTACACTGTCTTATTATAGAGAAGTAATAGACCTATCA GAACCTGCACTGACCAACAAATAAACACATGTTGCCAAGATGAATCGGTCTCTATCTCTATCTGCTTATTTTGGTACTGAAAGCAATAGTTCCTCATTCA AATCACCACCCACTGTTCTCCCCCTTTGGGACATGTTAGGACGAGGCCCTATTCCATGCCCCTCTTTAATGGTGGAACAAATGTTAAACTGCTCATCTAA AGATCATGTTGATATTATTCCAGGTTTTAAGATCAACTTTTGTTACATACTGTAATTTAAATAAACTGCATTTACATGCCTAGTTTCTGTAATATTGTGT ATACAAAACCCAAATCTCTCAAAATGTAAATTATGTATACCTGCCAAGATACCTTTTCCAGGGTGTCTGCGCACATTTTAAGTTAATTCACATAATATAA AAATTACTCAATGTGACTGTTGATTTGCTGAACTTTACATATCACAAAGTGAATTATTTGTGATACTTTAGTTAATAAAATGGTAAATTTTTTTCTCAGT TATTGAACAAGCAAGCATTATCCAGTTGATCTGGCAATGACTTTTTGTGTGTGGGCCACAATATTGATTTTCCCATTAACAATTTTTTTTTGTTTTTTAA ATACTAATATGTTTCACACTATAGTTTGTGTAACAACACGTGTTCGCATTATCTATGTTGCTGTTACTTTTGTGCTTTTATTCTTTTTAGACTTTATAAA AAAAAAAAAAAGCTCCTGTAATTTGCACTTTCTCCCAATCCTTAAATCTCTTGTATGGCAACCAAAATTACTGTAAAAAAATAAATATACTATTGCACTA AGGTTGTGGTTCTGATTGCAAACAAACAGTGAACACTGTCTGAATTAAACAAAAAGCTGCCCGACTTGCAATCTAATGTAGATTATCTCAGGCATTGTGG CCAGCTCTGCCTCTCTAAAACTGACCAGAAAAATCTCTCTCATCGAGTAAACAGGCTCCTGTCACTGAGCTAATCTGCCTTGGTTCCATTTCCTTATTCT CAATTTATCAATGGATACGTGCATGTTATTTCAGAATTATGCAAAACGTCAAAATCTGCTTCTGTGACCGCTGCTATAGGCGTGGAGCTGAGGCTCGGCT TTTCCTTTTGTTCTGGGTGGAAGCAGCGGTGCCGCGGAGGGCCAGCCAGATCCGGACCCTTCCCTTAGGGTCCAGTCTCCCCACACCCCAGCAGGGTGTC TTCTAGCCATAAGGCCAAGGGAGTGGCAGAACTGGGCCGCCTCTCTGGTTGACAAGCAAACCACATGCTAAGGCTTGGAGCAAGAGAGAATTTGTGTCTA TTGGCAAAGAACTAAGCCAGGAAGACATGGGCCATCCCTCCGCTTTAGGGAAGCATATTTTAAACCTAAACGTTGAACTTCTTCTTTGGCCTCACCAGTG AAAACTTGTTGTCTTTAGTTCCTAAAGTTTCTTCTACTTTGGCACATTCCCCAGTTGAGCAGCAGCCTCTATGCTTCCACGTTCAGGAAAAATTCCAGTC CTCATATCTTTTGTAGTTCACCCTCAAGCTCTCCCGCTTCACCATCCAATAGTTTCTCCCAAACCTTGGCACCCCCCTAGACTTTGCTTCCAATGGTTTC TTCCAGACCACTTTTCCTAGATGAATATATTCGTTTACCTTACTAGGAAAATTATTGGAAGATTTTTTCTTTTACTTGAAATTGGAGGCATTTTAATAAC TGGCGAACTGGAATGTGTTTCTGTATTTGTAGACAACCATGAACCCATGCAAGTAGGTGAACATTCCACAGTGGCTGGGTGACCACAGCAGCTGCATGCA GACAGGACTGCCCGTGCTTTGTGGGGAATCAGAGAATTTCCAAACTTGTTTCTCAGACTTCCGCAGATCTCATCACTTTGATTTCTAATCCATGCTGTAT TGGTGATTTTGTTTATCGTTCCTGTAACTTGTTCTACATTCCACAGTCTTTACCGTTTTATGTTCAAAATTACAACAATCCCTGTCCATTGATTCCACTC TGGAACTCTTTGTTCATGCCAATTTTGAAATTTTAATACGAGCCTTCAAATAAACACAGAAAAGAAAAAAAAAAAGGAAAAAAAATAAAGTGTGTGCCTT GGGTGTTTTGAACCTGATCTGCATAAAACCATATTGTATTCAAATGCTGTATCTTTCATGAAAGGATAAATATATCTTCAATGTATTAATGTAGCTGATA AAATAGTTATAGTGCCTTGTTTTCTGAACTGAGAAGCCCATATCAATGCACAACGTAAAGAAAGGACGGTTCGAGCTATGAAATGTTGAGGACACCTACA CGTGATTCTGGAGCCTTTCTCATCATAAGACTGTGGAAAATACACAGTCGTTTAAGTTAAAAATAAAAAGTAAATTGA

refseq_SHANK2.F1 (forward primer)
refseq_SHANK2.R1 (reverse primer)
Single exon skipping

Frame 0

MMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCI IEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTP TPAFPALQYLESVDEGGVAWQAGLRTGDFLIEV NNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTR NLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSE LEELVDKDKPEEIVPASKPSRAAENMAVEPRVA TIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTV PGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEE ERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVP PSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNS AAKVSPATRSDTVATMMREKGMYFRRELDRYSLD SEDLYSRNAGPQANFRNKRGQMPENPYSEVGKI ASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCS IPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEP PSQLRPDESLTVSSPFAAAIAGAVRDREKRLEA RRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPE EGDFADEDSAEQLSSPMPSATPREPENHFVGGAE ASAPGEAGRPLNSTSKAQGPESSPAVPSASSGT AGPGNYVHPLTGRLLDPSSPLALALSARDRAMK ESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFP TVTRQNTRGPLRRQETENKYETDLGRDRKGDDK KNMLIDIMDTSQQKSAGLLMVHTVDATKLDNAL QEEDEKAEVEMKPDSSPSEVPEGVSETEGALQIS AAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPP LASVDLDEDFIFTEPLPPPLEFANSFDIPDDRA ASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADS KKPASLSNCLPASFLPPPESFDAVADSGIEEVD SRSSSDHHLETTSTISTVSSISTLSSEGGENVD TCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNAL YQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAK VLQPRTSKLWGDVTEIKSPILSGPKANVISELN SILQQMNREKLAKPGEGLDSPMGAKSASLAPRSP EIMSTISGTRSTTVTFTVRPGTSQPITLQSRPP DYESRTSGTRRAPSPVVSPTEMNKETLPAPLSA ATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSR SPSPSILQQPISNKPFTTKPVHLWTKPDVADWL ESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDL GVTRVGHRMNIERALKQLLDR*GRLLSTSQTALV ISRDGLVLKHLNAKRSL*ASTPLHGFVSWYPKK Y*VVSTTWLGLQTPGSPCGCLGQFLSHMGQGEG VFLTWKKILSLPPSMQVASLCRVREAPRQFCTGS *LL*ADTSAL*IPPETSVLCFPGSSHHPRPRHE AFPQSCGLSEDT*CSPAPLSPALGLQ*DAPRCI CPVPHHGPERQRNFFLHRFFSPSPPVVCIHGSLA MRFLAVLGVWMGSCPALLSFLYFCKSVSIIPRW PSRCHMELVKAQSHDSTMEGRPGQGSQPACNCP SSRSPGQEQLSAMSTHPGWRIRASLPLRILFN*R CLELCKDQSR*ASTLT*RTRRRMAHGGHMRLPV RQRLLWELGGHSILSSVPSQG*ASLLRQSFCSR RPGKMVLRGFSPIALGV*ESHQLVLTVQQLL*GP SGYGV*TEPRVENRRWAAGSE*KQRREERKAGR SPGLPGQPLWQGFLEPRPFLSPESLHPITIPRI SKRGHQMHMGRKTHSQASSTFSPIWRILECQVFG FIIISELAQPISNYKTWFCFFFFLFFLIRSGTA LE*THKI*QFKIFLYCKFK*LYR*FISTIF*EK KVAGLLGSLCATSVLES*RKKNFCDLIILFLWNN YKSMTFLNQPYLDASEPAELCYIFYLC*NFVIE GQFLQSGYNS*CSSFSKNKNKTHTTHTRFSSHT PLMLEPSFWTFCSKTFCRSIFVFEMIQSNLKSIE Y*GALLPCAFSFSIMR*MSITLDKFQDRILQVA C*GCPIF*KM*KWWFGH*FVFHLMIPQNSVSPF LWHGTFPGPTVGITSVLSARQNTSSKESQGNRWQ TITSRNS*LRFVELWQPVGEGQMLFPFLKILQA TCH*PQASWLQD*RADNIVYFYTVLL*RSNRPI RTCTDQQINTCCQDESVSISICLFWY*KQ*FLIQ ITTHCSPPLGHVRTRPYSMPLFNGGTNVKLLI* RSC*YYSRF*DQLLLHTVI*INCIYMPSFCNIV YTKPKSLKM*IMYTCQDTFSRVSAHILS*FT*YK NYSM*LLIC*TLHITK*IICDTLVNKMVNFFLS Y*TSKHYPVDLAMTFCVWATILIFPLTIFFCFL NTNMFHTIVCVTTRVRIIYVAVTFVLLFFLDFIK KKKSSCNLHFLPILKSLVWQPKLL*KNKYTIAL RLWF*LQTNSEHCLN*TKSCPTCNLM*IISGIV ASSASLKLTRKISLIE*TGSCH*ANLPWFHFLIL NLSMDTCMLFQNYAKRQNLLL*PLL*AWS*GSA FPFVLGGSSGAAEGQPDPDPSLRVQSPHTPAGC LLAIRPREWQNWAASLVDKQTTC*GLEQERICVY WQRTKPGRHGPSLRFREAYFKPKR*TSSLASPV KTCCL*FLKFLLLWHIPQLSSSLYASTFRKNSS PHIFCSSPSSSPASPSNSFSQTLAPP*TLLPMVS SRPLFLDEYIRLPY*ENYWKIFSFT*NWRHFNN WRTGMCFCICRQP*THASR*TFHSGWVTTAAAC RQDCPCFVGNQRISKLVSQTSADLITLISNPCCI GDFVYRSCNLFYIPQSLPFYVQNYNNPCPLIPL WNSLFMPILKF*YEPSNKHRKEKKKGKKIKCVP WVF*T*SA*NHIVFKCCIFHERINISSMY*CS** NSYSALFSELRSPYQCTT*RKDGSSYEMLRTPT RDSGAFLIIRLWKIHSRLS*K*KVN*

Frame 1

***TSPAEERPR***RATIMVAVPGILSTVTAL LRRRRWSCRKKTMRALDSCFEGPKLTHPLKNSH QHRLSQPYSTWSPWMKVGWRGKPD*GPGTS*LRL TMRMLSKSATGRW*T*SGREGITWSLRWSR*PG IWTPTTPPGRKLPRLQSGHRPQPSPCAPSP*PR SWRSSWIKINPRR*SRPPSPPALLRTWLWNRGWR PSSSGPAAGASRRAQT*TLCTNAKESP**RPLF LGAQKPRFWASLEVRCEGRNQ*TAESFYQE*QR KSGSFWLLQC*SSPEACPCRTPLRTSPLHRSLCP RPHHHLPQPLTTAPSPQLQESTGRLSLRSIRIL PPRCPPPPGPTPWPP**GRRGCTSGESWTATPW TLKTSTVGMPARKPTSATREARCQKTHTQRWGRS PAKPSTSPPSPPGGRGCW*SSPTWRTAPRRRAP SLSRPSS*RSRPPAAAARAARAAAWRSTPRPRS HRASCGLTKA*PSAAPLPPPSPEPSATVRSGWKP GGTPRPSSPQTWGMRMWAWGHPPPGRGPPCSPR RGILLTRTALSSCHPPCRVPRPGSPKTISWVAP RPVLRVRLGGR*IPRPKPRGPRAAQQCPPRAAAQ PAPGIMSTHSQGGCLIPAPRWPWHSPQGTEP*R SLNRDPKGRPPRPTSTNLFTLIPKCGPAWMPAS LRSPGRTPGDP*GGRRRRTSTRPTWAETGKAMTR RTC*STSWTRPSRSRLAC*WCTPWTPLSWTTPC RKRTRRQRWR*SQTARRPRCQKVFPKPKVLYRS PLPPSPPPCPAEPSSRWAPWKRR*FCHSASLLPL WHPWTWMRILFLQSHCLLPWNLQIVLISPMTGQ LLSRLSQT**SRRKATPLSPLR*TPANQPTLQT ARSQPVFQTVCLPHSCHPLKALTPSPTLGSRRWT AGVAATTTSRRPALSPPCLASPPCLPKVERMWT PAQSMQMGKHLWLTNPQYLLSQK*SPSFTKAMH FIKTRSWKKM*IALLSPRPLPRPRRAVPSLGWPR FSSQGPPSCGATSQRSKARFSQAQRQTLLVN*T LSYSK*TERNWQSRGKDWIHQWEPSPPASLQEA RRS*APSQVHGARRSPSLFAPAPPSPSPCRAGPP TMKAGPQEQDVPQALWSRQQR*TKRPCPPPCLL PPPLLLPLSQMSLAFQASPLLGIYLA*TQRDAV GRHPPRYCNSQSQISLLQLNLSTCGLNQMWPIGW KV*TWVNIKRPSWTMRSMAVTYQTCRRRTSSIL G*LESGTE*T*KGL*NSCWTDKDGCSPPRRLLL L*VEMGSC*NI*MPSEVCEHQPHSMGLSPGTQRN TELCPQHGWVFRPLAHHVGVLGSFYHTWDKGRE FF*HGKRFSACRPACRWPRFAGSERLPVNFARD PSSCRQTPVHSRYLLRPPSSAFRAALTTPGPGMR PFLSPVASQRTPDAHLPLFLLHLACSEMLPDAF VQCPIMGLKGRETFSYTDSFPHLLLWFASMALW P*GSWQCWEFGWDRAQLCLAFFISANLLA*FQGG QADVTWS*SKHKVTIPQWRGDLAKGASQRATAQ APGLQDKSSCLP*APIQDGE*GLLCLSEFFLIE DVLSSAKIRAGEHPL*HEGQEDAWLMAGTCGCQ* DSVSSGSWAGTASSVLCPAKGEHLC*DSPFALG GQGRWYLEAFPLSLWVSRNPTSLS*QYNSFFED PVGMEYRQNPGLRTEGGRQDQSESRGVRRGKQGG LLGCQVSLSGKAFLSPAPFFPRSPSTP*QYLEF PKEVTRCTWAAKHTVRLPAHSPPFGGYSNVRFL VLLLFQN*LSPSLIIKHGFVFFFSFFS*LGLEQL *NEHIKFSNLKSFFTASLNSCTDSL*AQYFKKK KWLVY*AAFVPLQC*KVKEKKTFVI**YYFCGI IIKV*PF*INLIWMHLNQQSCVIFSIFARTSSLK DNFFKVVTIHNAAVSPKTKTKHTPHTRAFPVTH P*CWNQVFGPSVPKPFAGQSLYLK*SNPT*SQL NIKALYFRVLSVFPS*DE*ALL*INFKTGYYRWP AEAAPYFRKCKNGGLAINLSSI**YRKIP*VHS FGMALSLGLQLVLPLCSVPGKTLAQRRVKETAG RR*PVETRDFGLLNFGSQLVRARCYSLS*RYSKP HATNHKQAGCKTKELIT*FIFTLSYYREVIDLS EPALTNK*THVAKMNRSLSLSAYFGTESNSSSF KSPPTVLPLWDMLGRGPIPCPSLMVEQMLNCSSK DHVDIIPGFKINFCYIL*FK*TAFTCLVSVILC IQNPNLSKCKLCIPAKIPFPGCLRTF*VNSHNI KITQCDC*FAELYISQSELFVIL*LIKW*IFFSV IEQASIIQLIWQ*LFVCGPQY*FSH*QFFFVF* ILICFTL*FV*QHVFALSMLLLLLCFYSF*TL* KKKKAPVICTFSQSLNLLYGNQNYCKKINILLH* GCGSDCKQTVNTV*IKQKAARLAI*CRLSQALW PALPL*N*PEKSLSSSKQAPVTELICLGSISLF SIYQWIRACYFRIMQNVKICFCDRCYRRGAEARL FLLFWVEAAVPRRASQIRTLPLGSSLPTPQQGV F*P*GQGSGRTGPPLWLTSKPHAKAWSKREFVS IGKELSQEDMGHPSALGKHILNLNVELLLWPHQ* KLVVFSS*SFFYFGTFPS*AAASMLPRSGKIPV LISFVVHPQALPLHHPIVSPKPWHPPRLCFQWF LPDHFS*MNIFVYLTRKIIGRFFLLLEIGGILIT GELECVSVFVDNHEPMQVGEHSTVAG*PQQLHA DRTARALWGIREFPNLFLRLPQISSL*FLIHAV LVILFIVPVTCSTFHSLYRFMFKITTIPVH*FHS GTLCSCQF*NFNTSLQINTEKKKKKEKK*SVCL GCFEPDLHKTILYSNAVSFMKG*IYLQCINVAD KIVIVPCFLN*EAHINAQRKERTVRAMKC*GHLH VILEPFSS*DCGKYTVV*VKNKK*I

Frame 2

DDERPRRRSGRGDDDGLQ*WSLSPEFSLQ*LHY *GEDGGPAEKRQ*GLWIRASRGQS*HTH*RIHT NTGFPSPTVPGVRG*RWGGVASRTKDRGLLD*G *Q*ECCQSRPQAGGEHDPAGRESPGP*GGHGDQE SGPRRHRQEESSPASKAGTDHSPHPALQVHDLG AGGARG*R*TRGDSPGLQALPRC*EHGCGTEGG DHQAAAQQPVLPGGLRHELCVRTPRNRRDDAHCS WEPKSPVSGHPSRYDAKAEINRQQNLSIRNNRG RAAVSGSSNAEVHQKPVHAGHL*GHPPSTAVCA PVPTTTFPNHLQLPQVPNSKSLRDD*ACVQSEFC RQGVPRHQVRHRGHHDEGEGDVLQERAGPLLLG L*RPLQSECRPASQLPQQERPDARKPILRGGED RQQSRLRPRQARQAEGDAGEAVQRGGQPREDVLH PYPDHHREGAVHQQQRQEQPGQQHGDRPPGPGA TEPAAA*RKPDRQQPLCRRHRRSRPRP*EAAGS QEELPGLPLHRPGG*GCGPGATRPQDAALHVPRG GGFC*RGQR*AAVIPHAECHAQGARKPFRGWRR GQCSG*GWEAAEFHVQSPGAREQPSSALREQRH SRPRELCPPTHRAAA*SQLPAGPGTLRKGPSHEG VSTGTQRGGPQGRPQQTSLH*YQNAAQPGCRLP YGHQAEHPGTPEAAGDGEQVRDRPGPRPERR*Q EEHADRHHGHVPAEVGWPADGAHRGRH*AGQRPA GRGREGRGGDEARQLAVRGARRCFRNRRCFTDL RCPRAHHRARQNHRRGGLHGRGGDFAIPHPSSP SGIRGLG*GFYFYRAIASSPGICK*F*YPR*PGS FCPGSLRLSEAEEKRHPSVPFVELQPTNQLCRQ QEASQSFKLSACLIPATP*KL*RRRRLWDRGGG QPE*QRPPPRDDQHYLHRV*HLHPVFRRWRECGH LHSLCRWASIYG*QTPSTS*AKNEAHHSQKQCT LSRRARGRRCR*LCYPPARSPAPAGQCPAWDGQ GSPAKDLQVVGRRHRDQKPDSLRPKGKRY**IEL YPTANEPREIGKAGGRTGFTNGSQVRQPRSKKP GDHEHHLRYTEHDGHLHCSPRHLPAHHPAEPAP RL*KQDLRNKTCPKPCGLANRDEQRDPARPPVCC HRLSFSRSLRCL*PSKPAPFWGSIWLEPSGTQ* VAIPLDTATANLK*AFYN*TCPPVD*TRCGRLA GKSKLG*T*RGLHGQ*DRWQSLTKPAEGGPHRSW GNSSRAQNEHRKGFETAAGQIRTAALHLADCSC YK*RWARAETSECQAKSVSINPTPWVCLLVPKE ILSCVHNMAGSSDPWLTMWVSWAVSITHGTRGGS FSNMEKDSQPAAQHAGGLALPGPRGSPSILHGI LALVGRHQCTLDTS*DLRPLLSGQLSPPQAPA* GLSSVLWPLRGHLMLTCPSFSCTWLAVRCSQMHL SSAPSWA*KAEKLFPTQILFPISSCGLHPWLFG HEVPGSAGSLDGIVPSFA*LSLFLQIC*HNSKV AKQMSHGVSQSTKSRFHNGGETWPREPASVQLPK LQVSRTRAVVCHEHPSRMENKGFSASQNSF*LK MS*ALQRSEQVSIHFDMKDKKTHGSWRAHAAAS ETASPLGAGRAQHPQFCAQPRVSISAETVLLLSE AREDGT*RLFPYRSGCLGIPPACLNSTTASLRT QWVWSIDRTQG*EQKVGGRIRVKAEA*GEESRE VSWAARSASLARLS*APPLSFPGVPPPHNNTSNF QKRSPDAHGPQNTQSGFQHILPHLEDTRMSGFW FYYYFRTSSAHL*L*NMVLFFFFPFFLD*VWNS SRMNT*NLAI*NLSLLQV*IVVQIVYKHNILRKK SGWSTRQPLCHFSARKLKKKKLL*FNNTISVE* L*KYDLFKSTLFGCI*TSRAVLYFLSLLELRH* RTISSKWLQFIMQQFLQKQKQNTHHTHALFQSHT PDVGTKFLDLLFQNLLQVNLCI*NDPIQLEVN* ILRRFTSVCFQFFHHEMNEHYSR*ISRQDTTGG LLRLPHILENVKMVVWPLICLPFDDTAKFRESIP LAWHFPWAYSWYYLCAQCQAKH*LKGESRKPLA DDNQSKLVTSVC*TLAASW*GPDVIPFLKDTPS HMPLTTSKLAARLKS**HSLFLHCLIIEK**TYQ NLH*PTNKHMLPR*IGLYLYLLILVLKAIVPHS NHHPLFSPFGTC*DEALFHAPL*WWNKC*TAHL KIMLILFQVLRSTFVTYCNLNKLHLHA*FL*YCV YKTQISQNVNYVYLPRYLFQGVCAHFKLIHII* KLLNVTVDLLNFTYHKVNYL*YFS**NGKFFSQ LLNKQALSS*SGNDFLCVGHNIDFPINNFFLFFK Y*YVSHYSLCNNTCSHYLCCCYFCAFILFRLYK KKKKLL*FALSPNP*ISCMATKITVKK*IYYCT KVVVLIANKQ*TLSELNKKLPDLQSNVDYLRHCG QLCLSKTDQKNLSHRVNRLLSLS*SALVPFPYS QFINGYVHVISELCKTSKSASVTAAIGVELRLG FSFCSGWKQRCRGGPARSGPFP*GPVSPHPSRVS SSHKAKGVAELGRLSG*QANHMLRLGARENLCL LAKN*ARKTWAIPPL*GSIF*T*TLNFFFGLTS ENLLSLVPKVSSTLAHSPVEQQPLCFHVQEKFQS SYLL*FTLKLSRFTIQ*FLPNLGTPLDFASNGF FQTTFPR*IYSFTLLGKLLEDFFFYLKLEAF** LANWNVFLYL*TTMNPCK*VNIPQWLGDHSSCMQ TGLPVLCGESENFQTCFSDFRRSHHFDF*SMLY W*FCLSFL*LVLHSTVFTVLCSKLQQSLSIDST LELFVHANFEILIRAFK*TQKRKKKRKKNKVCAL GVLNLICIKPYCIQMLYLS*KDKYIFNVLM*LI K*L*CLVF*TEKPISMHNVKKGRFEL*NVEDTY T*FWSLSHHKTVENTQSFKLKIKSKL

Sequence NM_012309

Frame 0

Frame 1

Frame 2

Sequence NM_133266

Frame 0

Frame 1

Frame 2