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Sequences

Sequence NM_001008744

ACTGCGCGCATGCGCGGCGGCCGCCGAAGGGGCGGGATCCGAGGCAAGCGTTGGTTCTGTGCGCCTCAGGAGTATAATGTCTCAGGAAGGCGATTATGGG AGGTGGACCATATCTAGTAGTGATGAAAGTGAGGAAGAAAAGCCAAAACCAGACAAGCCATCTACCTCTTCTCTTCTCTGTGCCAGGCAAGGAGCAGCAA ATGAGCCCAGGTACACCTGTTCCGAGGCCCAGAAAGCTGCACACAAGAGGAAAATATCACCTGTGAAATTCAGCAATACAGATTCAGTTTTACCTCCCAA AAGGCAGAAAAGCGGTTCCCAGGAGGACCTCGGCTGGTGTCTGTCCAGCAGTGATGATGAGCTGCAACCAGAAATGCCGCAGAAGCAGGCTGAGAAAGTG GTGATCAAAAAGGAGAAAGACATCTCTGCTCCCAATGACGGCACTGCCCAAAGAACTGAAAATCATGGCGCTCCCGCCTGCCACAGGCTCAAAGAGGAGG AAGACGAGTATGAGACATCAGGGGAGGGCCAGGACATTTGGGACATGCTGGATAAAGGGAACCCCTTCCAGTTTTACCTCACTAGAGTCTCTGGAGTTAA GCCAAAGTATAACTCTGGAGCCCTCCACATCAAGGATATTTTATCTCCTTTATTTGGGACGCTTGTTTCTTCAGCTCAGTTTAACTACTGCTTTGACGTG GACTGGCTCGTAAAACAGTATCCACCAGAGTTCAGGAAGAAGCCAATCCTGCTTGTGCATGGTGATAAGCGAGAGGCTAAGGCTCACCTCCATGCCCAGG CCAAGCCTTACGAGAACATCTCTCTCTGCCAGGCAAAGTTGGATATTGCGTTTGGAACACACCACACGAAAATGATGCTGCTGCTCTATGAAGAAGGCCT CCGGGTTGTCATACACACCTCCAACCTCATCCATGCTGACTGGCACCAGAAAACTCAAGGAATATGGTTGAGCCCCTTATACCCACGAATTGCTGATGGA ACCCACAAATCTGGAGAGTCGCCAACACATTTTAAAGCTGATCTCATCAGTTACTTGATGGCTTATAATGCCCCTTCTCTCAAGGAGTGGATAGATGTCA TTCACAAGCACGATCTCTCTGAAACAAATGTTTATCTTATTGGTTCAACCCCAGGACGCTTTCAAGGAAGTCAAAAAGATAATTGGGGACATTTTAGACT TAAGAAGCTTCTGAAAGACCATGCCTCATCCATGCCTAACGCAGAGTCCTGGCCTGTCGTAGGTCAGTTTTCAAGCGTTGGCTCCTTGGGAGCCGATGAA TCAAAGTGGTTATGTTCTGAGTTTAAAGAGAGCATGCTGACACTGGGGAAGGAAAGCAAGACTCCAGGAAAAAGCTCTGTTCCTCTTTACTTGATCTATC CTTCTGTGGAAAATGTGCGGACCAGTTTAGAAGGATATCCTGCTGGGGGCTCTCTTCCCTATAGCATCCAGACAGCTGAAAAACAGAATTGGCTGCATTC CTATTTTCACAAATGGTCAGCTGAGACTTCTGGCCGCAGCAATGCCATGCCACATATTAAGACATATATGAGGCCTTCTCCAGACTTCAGTAAAATTGCT TGGTTCCTTGTCACAAGCGCAAATCTGTCCAAGGCTGCCTGGGGAGCATTGGAGAAGAATGGCACCCAGCTGATGATCCGCTCCTACGAGCTCGGGGTCC TTTTCCTCCCTTCAGCATTTGGTCTAGACAGTTTCAAAGTGAAACAGAAGTTCTTCGCTGGCAGCCAGGAGCCAATGGCCACCTTTCCTGTGCCATATGA TTTGCCTCCAGAACTGTATGGAAGTAAAGATCGGCCATGGATATGGAACATTCCTTATGTCAAAGCACCGGATACGCATGGGAACATGTGGGTGCCCTCC TGAGAATCTTGAGGCACTGTGAAATTTAAGTGTAAGACATTGAGCCACAAACATGGAATCTCTTCTTTGTACTGGATGTCCACTTCCCTTAAAGTCTTAT TTGCACCCTTACAAAATCTTTCCAAAGGTCACTCTTATGAATGGATGTTGGTTATACTTTTAATGGACATTAACATTCCTAATAAAGTATTAGTTTCTTA ATTCACTTTTATATGTTTTGGAAAGAAAATTAGTGAACTTCTCTATGTTAAAAATACGTACTGCTTGAGTATCCCCTGTCTGAAATGCTTGGGACCAGAA GTGTTTCAGCTTTTGGATTTTTTTGAATTTTGGAATATTTGCATAGCATAATGAGATATCTTGGGAATGGGACCCAAATCTAAACACAAAATTCATTTAT GTTTCATATACACCTTATATACAATAACCTAAAGGTGATTTTATATGATATTTTGAGTAATTTTATGCATGAAACAAAGTTTTGACAGGCTTTTGACCGT GATTCATCACATGAGTTCAGGCATGGAAATTTTCATTTGGAGCATCATGTCAGCACTCAAAAAGTTCTGGATCTTGGAGCAGTTCAGATTTTCAGATTAG GGATGCTCAAATCTATATAGATATAAAATTATCCTCACAGTAACATAGAATCTCTTGGTGCTGTCAGCTGTTGGGAATTGAAGATTGACTTTGTGCTTCC ACCCTCCATCCAGAAAGGCACCCTTCATTCCACCAGAACTTTACCCAGGAAGAACACGATCATTTCCTTTTTCACCGATGCCCTCTCTCAGCTTTCTGAG TACGTCTCTTGGGGTCGCTGGAGGTGATCCTAGGATCTGTCTCTGAGACCAATGTGCTGTTTCAGCCCCCTGCAGCTAAGAATTGTATTGACTGTCCTCA CAGCGGCTTTTCATAGCTTTCAGCTTCAGCTTTACGAGGCTTCTCCTCTCTCCCTGGCACCCTGCTGGCTGCCTCACTGCTTACAGACAGGTCCCACCAA ACCCAAACACCTGCCTAGGGTAAATGGGTCTCTCTTCTATCCCCAGAAACTTTCAGAGGAAGCAGCTCATAGAAACATACAAAAGCACACAAGTATTTTG GGAAAAAATCCTAAAAGGTGACTTAATTTGATGCCTTAAATTCACAAGTGAGGAAGCTAAGGCCTAGAAGGTTAAGGATGTCCCCAGGGTCACACAGTGA GCGGGGCTCAGAGCTTGAGTGTCTTTGTGCTTTGTGTACATTGTGTTCTCCCTAGGGTGCTTTAGACCCTGTTTGTTTTCTTCTGCATGAGGCTGATTTC CAGTTTGTCATCAACCTCTTTATCTTATAATTTAGGATAGAGTTGAACGTTAGTCTTGAAAGATTTTCTAAAGTAGTCTTTCAAACTGTTCCTCAGAGGC CTAGGATTTTCCAAAAGTACCTTAGGAACCTTGTAGGCTGCAGTGGGGGTGTGGCGATAGAGCAGGAGGCAGGGAGACAGGGCTGCAGGGCCTCCCACCT TCCAACAGACAGGCTCTGCTGTATCTGTTGTACATACTGGGATTCTGTAAAGGACATTATCTGGGGTGTTGTATGTATTTTTGTGTGTTCTGCTTTTTTT AAATAAACTTGAAAAGCTACTGAA

refseq_TDP1.F1 (forward primer)
refseq_TDP1.R1 (reverse primer)
Single exon skipping

Frame 0

TARMRGGRRRGGIRGKRWFCAPQEYNVSGRRLW EVDHI****K*GRKAKTRQAIYLFSSLCQARSSK *AQVHLFRGPESCTQEENITCEIQQYRFSFTSQ KAEKRFPGGPRLVSVQQ***AATRNAAEAG*ES GDQKGERHLCSQ*RHCPKN*KSWRSRLPQAQRGG RRV*DIRGGPGHLGHAG*REPLPVLPH*SLWS* AKV*LWSPPHQGYFISFIWDACFFSSV*LLL*R GLARKTVSTRVQEEANPACAW**ARG*GSPPCPG QALREHLSLPGKVGYCVWNTPHENDAAAL*RRP PGCHTHLQPHPC*LAPENSRNMVEPLIPTNC*W NPQIWRVANTF*S*SHQLLDGL*CPFSQGVDRCH SQARSL*NKCLSYWFNPRTLSRKSKR*LGTF*T *EASERPCLIHA*RRVLACRRSVFKRWLLGSR* IKVVMF*V*REHADTGEGKQDSRKKLCSSLLDLS FCGKCADQFRRISCWGLSSL*HPDS*KTELAAF LFSQMVS*DFWPQQCHATY*DIYEAFSRLQ*NC LVPCHKRKSVQGCLGSIGEEWHPADDPLLRARGP FPPFSIWSRQFQSETEVLRWQPGANGHLSCAI* FASRTVWK*RSAMDMEHSLCQSTGYAWEHVGAL LRILRHCEI*V*DIEPQTWNLFFVLDVHFP*SLI CTLTKSFQRSLL*MDVGYTFNGH*HS**SISFL IHFYMFWKEN**TSLC*KYVLLEYPLSEMLGTR SVSAFGFF*ILEYLHSIMRYLGNGTQI*TQNSFM FHIHLIYNNLKVILYDILSNFMHETKF*QAFDR DSSHEFRHGNFHLEHHVSTQKVLDLGAVQIFRL GMLKSI*I*NYPHSNIESLGAVSCWELKIDFVLP PSIQKGTLHSTRTLPRKNTIISFFTDALSQLSE YVSWGRWR*S*DLSLRPMCCFSPLQLRIVLTVL TAAFHSFQLQLYEASPLSLAPCWLPHCLQTGPTK PKHLPRVNGSLFYPQKLSEEAAHRNIQKHTSIL GKNPKR*LNLMP*IHK*GS*GLEG*GCPQGHTV SGAQSLSVFVLCVHCVLPRVL*TLFVFFCMRLIS SLSSTSLSYNLG*S*TLVLKDFLK*SFKLFLRG LGFSKSTLGTL*AAVGVWR*SRRQGDRAAGPPT FQQTGSAVSVVHTGIL*RTLSGVLYVFLCVLLFL NKLEKLL

Frame 1

LRACAAAAEGAGSEASVGSVRLRSIMSQEGDYG RWTISSSDESEEEKPKPDKPSTSSLLCARQGAA NEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPK RQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKV VIKKEKDISAPNDGTAQRTENHGAPACHRLKEE EDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVK PKYNSGALHIKDILSPLFGTLVSSAQFNYCFDV DWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQ AKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGL RVVIHTSNLIHADWHQKTQGIWLSPLYPRIADG THKSGESPTHFKADLISYLMAYNAPSLKEWIDV IHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRL KKLLKDHASSMPNAESWPVVGQFSSVGSLGADE SKWLCSEFKESMLTLGKESKTPGKSSVPLYLIY PSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHS YFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIA WFLVTSANLSKAAWGALEKNGTQLMIRSYELGV LFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYD LPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS *ES*GTVKFKCKTLSHKHGISSLYWMSTSLKVL FAPLQNLSKGHSYEWMLVILLMDINIPNKVLVS* FTFICFGKKISELLYVKNTYCLSIPCLKCLGPE VFQLLDFFEFWNICIA**DILGMGPKSKHKIHL CFIYTLYTIT*R*FYMIF*VILCMKQSFDRLLTV IHHMSSGMEIFIWSIMSALKKFWILEQFRFSD* GCSNLYRYKIILTVT*NLLVLSAVGN*RLTLCF HPPSRKAPFIPPELYPGRTRSFPFSPMPSLSFLS TSLGVAGGDPRICL*DQCAVSAPCS*ELY*LSS QRLFIAFSFSFTRLLLSPWHPAGCLTAYRQVPP NPNTCLG*MGLSSIPRNFQRKQLIETYKSTQVFW EKILKGDLI*CLKFTSEEAKA*KVKDVPRVTQ* AGLRA*VSLCFVYIVFSLGCFRPCLFSSA*G*F PVCHQPLYLII*DRVER*S*KIF*SSLSNCSSEA *DFPKVP*EPCRLQWGCGDRAGGRETGLQGLPP SNRQALLYLLYILGFCKGHYLGCCMYFCVFCFF *INLKSY*

Frame 2

CAHARRPPKGRDPRQALVLCASGV*CLRKAIMG GGPYLVVMKVRKKSQNQTSHLPLLFSVPGKEQQ MSPGTPVPRPRKLHTRGKYHL*NSAIQIQFYLP KGRKAVPRRTSAGVCPAVMMSCNQKCRRSRLRKW *SKRRKTSLLPMTALPKELKIMALPPATGSKRR KTSMRHQGRARTFGTCWIKGTPSSFTSLESLEL SQSITLEPSTSRIFYLLYLGRLFLQLSLTTALTW TGS*NSIHQSSGRSQSCLCMVISERLRLTSMPR PSLTRTSLSARQSWILRLEHTTRK*CCCSMKKA SGLSYTPPTSSMLTGTRKLKEYG*APYTHELLME PTNLESRQHILKLISSVT*WLIMPLLSRSG*MS FTSTISLKQMFILLVQPQDAFKEVKKIIGDILD LRSF*KTMPHPCLTQSPGLS*VSFQALAPWEPMN QSGYVLSLKRAC*HWGRKARLQEKALFLFT*SI LLWKMCGPV*KDILLGALFPIASRQLKNRIGCI PIFTNGQLRLLAAAMPCHILRHI*GLLQTSVKLL GSLSQAQICPRLPGEHWRRMAPS**SAPTSSGS FSSLQHLV*TVSK*NRSSSLAARSQWPPFLCHM ICLQNCMEVKIGHGYGTFLMSKHRIRMGTCGCPP ENLEAL*NLSVRH*ATNMESLLCTGCPLPLKSY LHPYKIFPKVTLMNGCWLYF*WTLTFLIKY*FL NSLLYVLERKLVNFSMLKIRTA*VSPV*NAWDQK CFSFWIFLNFGIFA*HNEISWEWDPNLNTKFIY VSYTPYIQ*PKGDFI*YFE*FYA*NKVLTGF*P *FIT*VQAWKFSFGASCQHSKSSGSWSSSDFQIR DAQIYIDIKLSSQ*HRISWCCQLLGIED*LCAS TLHPERHPSFHQNFTQEEHDHFLFHRCPLSAF* VRLLGSLEVILGSVSETNVLFQPPAAKNCIDCPH SGFS*LSASALRGFSSLPGTLLAASLLTDRSHQ TQTPA*GKWVSLLSPETFRGSSS*KHTKAHKYF GKKS*KVT*FDALNSQVRKLRPRRLRMSPGSHSE RGSELECLCALCTLCSP*GALDPVCFLLHEADF QFVINLFIL*FRIELNVSLERFSKVVFQTVPQR PRIFQKYLRNLVGCSGGVAIEQEAGRQGCRASHL PTDRLCCICCTYWDSVKDIIWGVVCIFVCSAFF K*T*KATE

Sequence NM_018319

ACTGCGCGCATGCGCGGCGGCCGCCGAAGGGGCGGGATCCGAGGCAAGCGTTGGTTCTGTGCGCCTCAGAGTTGGAGCACACAGCTGTATTAAAAAGGCA AATCGAAGGCCGGGCGCGGTGACTCACGCCTGTCATCCTAGCACTTTGGGAGGCCGAGGCGGCTGAATCACTTGAGGTTAGGAGTTTGAGATCAGCCCGG GCAACATGGTGAAACCCCGTCTCTACAAAAATAGAAAAATTAGCCGAGCGTGATGGTGGATGCCTGTAATCCTAGCTCCTCGGGAGGCTAAGGAGTATAA TGTCTCAGGAAGGCGATTATGGGAGGTGGACCATATCTAGTAGTGATGAAAGTGAGGAAGAAAAGCCAAAACCAGACAAGCCATCTACCTCTTCTCTTCT CTGTGCCAGGCAAGGAGCAGCAAATGAGCCCAGGTACACCTGTTCCGAGGCCCAGAAAGCTGCACACAAGAGGAAAATATCACCTGTGAAATTCAGCAAT ACAGATTCAGTTTTACCTCCCAAAAGGCAGAAAAGCGGTTCCCAGGAGGACCTCGGCTGGTGTCTGTCCAGCAGTGATGATGAGCTGCAACCAGAAATGC CGCAGAAGCAGGCTGAGAAAGTGGTGATCAAAAAGGAGAAAGACATCTCTGCTCCCAATGACGGCACTGCCCAAAGAACTGAAAATCATGGCGCTCCCGC CTGCCACAGGCTCAAAGAGGAGGAAGACGAGTATGAGACATCAGGGGAGGGCCAGGACATTTGGGACATGCTGGATAAAGGGAACCCCTTCCAGTTTTAC CTCACTAGAGTCTCTGGAGTTAAGCCAAAGTATAACTCTGGAGCCCTCCACATCAAGGATATTTTATCTCCTTTATTTGGGACGCTTGTTTCTTCAGCTC AGTTTAACTACTGCTTTGACGTGGACTGGCTCGTAAAACAGTATCCACCAGAGTTCAGGAAGAAGCCAATCCTGCTTGTGCATGGTGATAAGCGAGAGGC TAAGGCTCACCTCCATGCCCAGGCCAAGCCTTACGAGAACATCTCTCTCTGCCAGGCAAAGTTGGATATTGCGTTTGGAACACACCACACGAAAATGATG CTGCTGCTCTATGAAGAAGGCCTCCGGGTTGTCATACACACCTCCAACCTCATCCATGCTGACTGGCACCAGAAAACTCAAGGAATATGGTTGAGCCCCT TATACCCACGAATTGCTGATGGAACCCACAAATCTGGAGAGTCGCCAACACATTTTAAAGCTGATCTCATCAGTTACTTGATGGCTTATAATGCCCCTTC TCTCAAGGAGTGGATAGATGTCATTCACAAGCACGATCTCTCTGAAACAAATGTTTATCTTATTGGTTCAACCCCAGGACGCTTTCAAGGAAGTCAAAAA GATAATTGGGGACATTTTAGACTTAAGAAGCTTCTGAAAGACCATGCCTCATCCATGCCTAACGCAGAGTCCTGGCCTGTCGTAGGTCAGTTTTCAAGCG TTGGCTCCTTGGGAGCCGATGAATCAAAGTGGTTATGTTCTGAGTTTAAAGAGAGCATGCTGACACTGGGGAAGGAAAGCAAGACTCCAGGAAAAAGCTC TGTTCCTCTTTACTTGATCTATCCTTCTGTGGAAAATGTGCGGACCAGTTTAGAAGGATATCCTGCTGGGGGCTCTCTTCCCTATAGCATCCAGACAGCT GAAAAACAGAATTGGCTGCATTCCTATTTTCACAAATGGTCAGCTGAGACTTCTGGCCGCAGCAATGCCATGCCACATATTAAGACATATATGAGGCCTT CTCCAGACTTCAGTAAAATTGCTTGGTTCCTTGTCACAAGCGCAAATCTGTCCAAGGCTGCCTGGGGAGCATTGGAGAAGAATGGCACCCAGCTGATGAT CCGCTCCTACGAGCTCGGGGTCCTTTTCCTCCCTTCAGCATTTGGTCTAGACAGTTTCAAAGTGAAACAGAAGTTCTTCGCTGGCAGCCAGGAGCCAATG GCCACCTTTCCTGTGCCATATGATTTGCCTCCAGAACTGTATGGAAGTAAAGATCGGCCATGGATATGGAACATTCCTTATGTCAAAGCACCGGATACGC ATGGGAACATGTGGGTGCCCTCCTGAGAATCTTGAGGCACTGTGAAATTTAAGTGTAAGACATTGAGCCACAAACATGGAATCTCTTCTTTGTACTGGAT GTCCACTTCCCTTAAAGTCTTATTTGCACCCTTACAAAATCTTTCCAAAGGTCACTCTTATGAATGGATGTTGGTTATACTTTTAATGGACATTAACATT CCTAATAAAGTATTAGTTTCTTAATTCACTTTTATATGTTTTGGAAAGAAAATTAGTGAACTTCTCTATGTTAAAAATACGTACTGCTTGAGTATCCCCT GTCTGAAATGCTTGGGACCAGAAGTGTTTCAGCTTTTGGATTTTTTTGAATTTTGGAATATTTGCATAGCATAATGAGATATCTTGGGAATGGGACCCAA ATCTAAACACAAAATTCATTTATGTTTCATATACACCTTATATACAATAACCTAAAGGTGATTTTATATGATATTTTGAGTAATTTTATGCATGAAACAA AGTTTTGACAGGCTTTTGACCGTGATTCATCACATGAGTTCAGGCATGGAAATTTTCATTTGGAGCATCATGTCAGCACTCAAAAAGTTCTGGATCTTGG AGCAGTTCAGATTTTCAGATTAGGGATGCTCAAATCTATATAGATATAAAATTATCCTCACAGTAACATAGAATCTCTTGGTGCTGTCAGCTGTTGGGAA TTGAAGATTGACTTTGTGCTTCCACCCTCCATCCAGAAAGGCACCCTTCATTCCACCAGAACTTTACCCAGGAAGAACACGATCATTTCCTTTTTCACCG ATGCCCTCTCTCAGCTTTCTGAGTACGTCTCTTGGGGTCGCTGGAGGTGATCCTAGGATCTGTCTCTGAGACCAATGTGCTGTTTCAGCCCCCTGCAGCT AAGAATTGTATTGACTGTCCTCACAGCGGCTTTTCATAGCTTTCAGCTTCAGCTTTACGAGGCTTCTCCTCTCTCCCTGGCACCCTGCTGGCTGCCTCAC TGCTTACAGACAGGTCCCACCAAACCCAAACACCTGCCTAGGGTAAATGGGTCTCTCTTCTATCCCCAGAAACTTTCAGAGGAAGCAGCTCATAGAAACA TACAAAAGCACACAAGTATTTTGGGAAAAAATCCTAAAAGGTGACTTAATTTGATGCCTTAAATTCACAAGTGAGGAAGCTAAGGCCTAGAAGGTTAAGG ATGTCCCCAGGGTCACACAGTGAGCGGGGCTCAGAGCTTGAGTGTCTTTGTGCTTTGTGTACATTGTGTTCTCCCTAGGGTGCTTTAGACCCTGTTTGTT TTCTTCTGCATGAGGCTGATTTCCAGTTTGTCATCAACCTCTTTATCTTATAATTTAGGATAGAGTTGAACGTTAGTCTTGAAAGATTTTCTAAAGTAGT CTTTCAAACTGTTCCTCAGAGGCCTAGGATTTTCCAAAAGTACCTTAGGAACCTTGTAGGCTGCAGTGGGGGTGTGGCGATAGAGCAGGAGGCAGGGAGA CAGGGCTGCAGGGCCTCCCACCTTCCAACAGACAGGCTCTGCTGTATCTGTTGTACATACTGGGATTCTGTAAAGGACATTATCTGGGGTGTTGTATGTA TTTTTGTGTGTTCTGCTTTTTTTAAATAAACTTGAAAAGCTACTGAA

refseq_TDP1.F1 (forward primer)
refseq_TDP1.R1 (reverse primer)
Single exon skipping

Frame 0

TARMRGGRRRGGIRGKRWFCAPQSWSTQLY*KG KSKAGRGDSRLSS*HFGRPRRLNHLRLGV*DQPG QHGETPSLQK*KN*PSVMVDACNPSSSGG*GV* CLRKAIMGGGPYLVVMKVRKKSQNQTSHLPLLF SVPGKEQQMSPGTPVPRPRKLHTRGKYHL*NSAI QIQFYLPKGRKAVPRRTSAGVCPAVMMSCNQKC RRSRLRKW*SKRRKTSLLPMTALPKELKIMALP PATGSKRRKTSMRHQGRARTFGTCWIKGTPSSFT SLESLELSQSITLEPSTSRIFYLLYLGRLFLQL SLTTALTWTGS*NSIHQSSGRSQSCLCMVISER LRLTSMPRPSLTRTSLSARQSWILRLEHTTRK*C CCSMKKASGLSYTPPTSSMLTGTRKLKEYG*AP YTHELLMEPTNLESRQHILKLISSVT*WLIMPL LSRSG*MSFTSTISLKQMFILLVQPQDAFKEVKK IIGDILDLRSF*KTMPHPCLTQSPGLS*VSFQA LAPWEPMNQSGYVLSLKRAC*HWGRKARLQEKA LFLFT*SILLWKMCGPV*KDILLGALFPIASRQL KNRIGCIPIFTNGQLRLLAAAMPCHILRHI*GL LQTSVKLLGSLSQAQICPRLPGEHWRRMAPS** SAPTSSGSFSSLQHLV*TVSK*NRSSSLAARSQW PPFLCHMICLQNCMEVKIGHGYGTFLMSKHRIR MGTCGCPPENLEAL*NLSVRH*ATNMESLLCTG CPLPLKSYLHPYKIFPKVTLMNGCWLYF*WTLTF LIKY*FLNSLLYVLERKLVNFSMLKIRTA*VSP V*NAWDQKCFSFWIFLNFGIFA*HNEISWEWDP NLNTKFIYVSYTPYIQ*PKGDFI*YFE*FYA*NK VLTGF*P*FIT*VQAWKFSFGASCQHSKSSGSW SSSDFQIRDAQIYIDIKLSSQ*HRISWCCQLLG IED*LCASTLHPERHPSFHQNFTQEEHDHFLFHR CPLSAF*VRLLGSLEVILGSVSETNVLFQPPAA KNCIDCPHSGFS*LSASALRGFSSLPGTLLAAS LLTDRSHQTQTPA*GKWVSLLSPETFRGSSS*KH TKAHKYFGKKS*KVT*FDALNSQVRKLRPRRLR MSPGSHSERGSELECLCALCTLCSP*GALDPVC FLLHEADFQFVINLFIL*FRIELNVSLERFSKVV FQTVPQRPRIFQKYLRNLVGCSGGVAIEQEAGR QGCRASHLPTDRLCCICCTYWDSVKDIIWGVVC IFVCSAFFK*T*KATE

Frame 1

LRACAAAAEGAGSEASVGSVRLRVGAHSCIKKA NRRPGAVTHACHPSTLGGRGG*IT*G*EFEISP GNMVKPRLYKNRKISRA*WWMPVILAPREAKEYN VSGRRLWEVDHI****K*GRKAKTRQAIYLFSS LCQARSSK*AQVHLFRGPESCTQEENITCEIQQ YRFSFTSQKAEKRFPGGPRLVSVQQ***AATRNA AEAG*ESGDQKGERHLCSQ*RHCPKN*KSWRSR LPQAQRGGRRV*DIRGGPGHLGHAG*REPLPVL PH*SLWS*AKV*LWSPPHQGYFISFIWDACFFSS V*LLL*RGLARKTVSTRVQEEANPACAW**ARG *GSPPCPGQALREHLSLPGKVGYCVWNTPHEND AAAL*RRPPGCHTHLQPHPC*LAPENSRNMVEPL IPTNC*WNPQIWRVANTF*S*SHQLLDGL*CPF SQGVDRCHSQARSL*NKCLSYWFNPRTLSRKSK R*LGTF*T*EASERPCLIHA*RRVLACRRSVFKR WLLGSR*IKVVMF*V*REHADTGEGKQDSRKKL CSSLLDLSFCGKCADQFRRISCWGLSSL*HPDS *KTELAAFLFSQMVS*DFWPQQCHATY*DIYEAF SRLQ*NCLVPCHKRKSVQGCLGSIGEEWHPADD PLLRARGPFPPFSIWSRQFQSETEVLRWQPGAN GHLSCAI*FASRTVWK*RSAMDMEHSLCQSTGYA WEHVGALLRILRHCEI*V*DIEPQTWNLFFVLD VHFP*SLICTLTKSFQRSLL*MDVGYTFNGH*H S**SISFLIHFYMFWKEN**TSLC*KYVLLEYPL SEMLGTRSVSAFGFF*ILEYLHSIMRYLGNGTQ I*TQNSFMFHIHLIYNNLKVILYDILSNFMHET KF*QAFDRDSSHEFRHGNFHLEHHVSTQKVLDLG AVQIFRLGMLKSI*I*NYPHSNIESLGAVSCWE LKIDFVLPPSIQKGTLHSTRTLPRKNTIISFFT DALSQLSEYVSWGRWR*S*DLSLRPMCCFSPLQL RIVLTVLTAAFHSFQLQLYEASPLSLAPCWLPH CLQTGPTKPKHLPRVNGSLFYPQKLSEEAAHRN IQKHTSILGKNPKR*LNLMP*IHK*GS*GLEG*G CPQGHTVSGAQSLSVFVLCVHCVLPRVL*TLFV FFCMRLISSLSSTSLSYNLG*S*TLVLKDFLK* SFKLFLRGLGFSKSTLGTL*AAVGVWR*SRRQGD RAAGPPTFQQTGSAVSVVHTGIL*RTLSGVLYV FLCVLLFLNKLEKLL

Frame 2

CAHARRPPKGRDPRQALVLCASELEHTAVLKRQ IEGRAR*LTPVILALWEAEAAESLEVRSLRSAR ATW*NPVSTKIEKLAERDGGCL*S*LLGRLRSI MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLL CARQGAANEPRYTCSEAQKAAHKRKISPVKFSN TDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEM PQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPA CHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFY LTRVSGVKPKYNSGALHIKDILSPLFGTLVSSA QFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREA KAHLHAQAKPYENISLCQAKLDIAFGTHHTKMM LLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP LYPRIADGTHKSGESPTHFKADLISYLMAYNAPS LKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQK DNWGHFRLKKLLKDHASSMPNAESWPVVGQFSS VGSLGADESKWLCSEFKESMLTLGKESKTPGKSS VPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRP SPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMI RSYELGVLFLPSAFGLDSFKVKQKFFAGSQEPM ATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT HGNMWVPS*ES*GTVKFKCKTLSHKHGISSLYWM STSLKVLFAPLQNLSKGHSYEWMLVILLMDINI PNKVLVS*FTFICFGKKISELLYVKNTYCLSIP CLKCLGPEVFQLLDFFEFWNICIA**DILGMGPK SKHKIHLCFIYTLYTIT*R*FYMIF*VILCMKQ SFDRLLTVIHHMSSGMEIFIWSIMSALKKFWIL EQFRFSD*GCSNLYRYKIILTVT*NLLVLSAVGN *RLTLCFHPPSRKAPFIPPELYPGRTRSFPFSP MPSLSFLSTSLGVAGGDPRICL*DQCAVSAPCS *ELY*LSSQRLFIAFSFSFTRLLLSPWHPAGCLT AYRQVPPNPNTCLG*MGLSSIPRNFQRKQLIET YKSTQVFWEKILKGDLI*CLKFTSEEAKA*KVK DVPRVTQ*AGLRA*VSLCFVYIVFSLGCFRPCLF SSA*G*FPVCHQPLYLII*DRVER*S*KIF*SS LSNCSSEA*DFPKVP*EPCRLQWGCGDRAGGRE TGLQGLPPSNRQALLYLLYILGFCKGHYLGCCMY FCVFCFF*INLKSY*