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Sequence XM_931455
GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC
CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT
AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG
TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT
ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA
GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG
AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA
AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT
GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA
CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC
AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT
TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC
CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC
ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT
CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT
GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA
GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT
AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA
GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG
AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC
CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT
GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA
AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA
AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG
TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG
AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG
CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG
CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA
GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG
GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA
AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGAACATATCCTCCCCTGAGAGTT
CCCCTGCGCATAGGCCCGAGTCCCTGTCACCCGAGCTTTGTCACCGAAAAGACCTGGATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTG
TGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTCCCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGA
GATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAACTTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAG
ATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATGGGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGA
ACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGCCTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGG
AAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCTGCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTG
CAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGCAGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATT
CTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAGAGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGC
AGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCCAAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGC
CCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAGAAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAAC
AGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGA
GGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCA
CGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAG
CACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAG
TCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGT
CAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACT
GCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCC
TCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGG
CCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGT
TTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTT
TTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTAT
GCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTAT
CTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAG
CTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAAC
CCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGAT
ACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGC
ATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGG
GATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCA
TCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTT
CTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAAT
CCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCT
CTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCTCTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAA
ATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACA
AACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATT
TGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGACCCCAGCC
ACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGGGGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTC
TCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGA
GAA
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
AAAARLRSETHAAPVPPVRQHSSAGPPLSLALPPLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA
*LESCRLPGVPCAAARAQAPAAPGTRSSELLAD
NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV
VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL
LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS
EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP
EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE
GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV
VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS
TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P
V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY
FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA
PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA
FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV
HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG
C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK
ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA
RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS
RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR
SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH
LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE
CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE
ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG
RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG
VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR
VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL
HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E
ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E**
LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS
ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS
KWIQPHVFTSHISYYC*SLQHSSTV*EHILP*EF
PCA*ARVPVTRALSPKRPGFGKSRIP*LQH*QL
C**TFPTQLRSF*PGSSSLPRTHF*DWFPKQKW
RWTSDPREKLRPGISDRVQLDVCLLPFECYASSR
WTVSRISSSGG*EAFTFGWGILFPCRRIFQQI*
TWLNERPLSWILVTWW*KGL*RSPICPPEPTTE
EKSIPAGVPKTETRS*GKFCWWGR*LCTEQKQVC
RSWARQQ*LRFRHWCPWCAGILSPNSIFPSQKI
LPISFLYVPFGGGKPIRFQRHFFISLQTSREYQ
Q*VDGSHISRTTPRRREHPQGPPKQREGGPKGRA
LSHMGE*HHRERLRPCRWRRPRDIKLSTL*RSN
SLQPFQIQLPAPAV**SSDRITKPPSAEFLPLQ
RTSYTVSRIQLSNYCTETWKPPLSRFFRIIPLFH
VLFQPRPPCVHRLVGPIYGDTRVF*QPATFWKQ
HWQQSSKEELPF*CC*PYPAGTLRLANLRFSFS
VQHRNSEFHLLSSEL*VVIAIRLTDYQSAQCWAV
SCLPGLQGICGFQFTALPTPWEWGCAPVPTPAT
ARVRSQDSDGTFLGLLDLGKQN*MSP*LLPSSC
LWNLGRAYC*GTGGTRCQRIGSGGQETRLVVTIG
LWPWRKL*ILSEAETIKKFLPAVKGTLLTSKWC
FG**RF*VQ*VVLKPPSPILACSP*SLVQ*GHL
FKFKKKKKKSFQRKKS*KSQSQSPKPSEYC*GFM
HLRKKVGM*MFILRQPFQKQVSGQCVSTKNTVY
LCLKITKK*ARIVKLGTCTNWRVPGSLKKSSWS
ALDYSGADYLSRLSEPPTVTILLPLPKLFHSSVT
HEVSRQEKEE*DMI*ANCIATYQLLAINFIRKD
TEWFGNASNFIFSTPN*SGVDDPMSRTASMIGE
HALVTAG*EWEDRFVEWHRQDCDCVWACPTFLWG
MLM*EWAQ*KSYQATHTPNTVLDER*EQTGFSP
SVHCACCTPLEEPWSQPRWGTQSF*IPYGCQLI
SFTCLL*YLACFYLSNFVFSYNHGRGSEYMTGVI
PGAAVDLLFFWTR*YCEFPSFLPSNLFSFFPQP
LASPSFLPCPTTIICTVFSLCV*LLQNFTFQNR
NQVFAQMRGDFFFFFFFKC*DLSRVLFFLLFPPQ
THQSGRALGVEIMLPGMLVSLYII*NVCKCLSI
WAGVCILPLAI*PRGEASGQAALTLPGTCRDPS
HSVWAGCCQDQTSWGGRGGGVGGTLGREEVSLLS
QVECLHLAVTFELSQEM**F***NS*P**S*S*
E
Frame 1
RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCPPSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG
PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI
IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW
SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS
YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ
RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP
NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG
KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL
YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA
PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD
QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI
LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH
RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG
HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF
IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD
AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK
RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL
EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV
DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV
EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT
SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS
VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP
KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE
EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV
SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ
ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC
TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK
RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS
SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR
PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR
NGYSLMFSPVTSLTTASRCNTPLQFENISSPES
SPAHRPESLSPELCHRKDLDLAKVGYLDSNTNSC
ADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSG
DGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRA
DGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYE
HGLMKDLSRGSLSPGGERACEGVPSAPQNPPQR
KKVSLLEYRKRKQEAKENSAGGGGDSAQSKSKS
AGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKF
SPSHSSMSHLEAVSPSDSRGTSSSHCRPQENIS
SRWMVPTSVERLREGGSIPKVLRSSVRVAQKGE
PSPTWESNITEKDSDPADGEGPETLSSALSKGAT
VYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFR
GHPTQSPGYSYRTTALRPGNPPSHGSSESSLSS
TSYSSPAHPVSTDSLAPFTGTPGYFSSQPHSGNS
TGSNLPRRSCPSSAASPTLQGPSDSPTSDSVSQ
SSTGTLSSTSFPQNSRSSLPSDLRTISLPSAGQ
SAVYQASRVSAVSNSQHYPHRGSGGVHQYRLQPL
QGSGVKTQTGLS*GFWIWANRTE*AHSCFLPAA
SGT*AEHIAEERGVQGARGLGLVDKKQDLWSQL
ASGLGESCKSCLKQRL*RSFSLLSRVHC*QANGV
SVSNGSKCNELC*SLRLPSLPVARSHLCSEDIF
LNLKKKKKKVFKGKKVKRANLKAPSHLSTVRVL
CT*EKR*VCKCSS*DNHSKSRYLANVCPPRILFI
FVLRSPRNRQG**SLEPAPTGGCLAL*RKAHGQ
LLIIREQII*VDCLSLQLLPSYSPFPSYFTAQ*
PMK*VDKKRRNET*YRPIALLLTSFWQ*ISLGRI
PSGLGMLRILFFLLPINQELMIP*AGPPP*LGS
MHL*LQGKSGKIGLWSGTDRTVIVCGPAPHFSG
GCLCESGPSERVTKPPTPLTLFWMRDESRPASPH
QCIVPVVHPWRSPGASPGGVHNLFKFHMVASLF
LSLVYCNIWRVFIYLILYSVITMVGVVNI*QV*
SLVLQWTFFSFGQDNTVSFPPSFPLICFPFFPSL
LHPLLFYPVLQLSYAQSSLFVCDCYKISLFKIE
IRCLLK*GEIFFFFFFLNAETSAEYFSFCCFPH
KPISLGEHWEWKSCCLGCWFLCILYKTYVNVSPF
GLGFAFSPWLFNQGERPAGRRPSPCLARAETPA
TLCGQGAVKTRPLGGVGAGGWGELLEGKKYHFF
LKWSVYTLL*HLNFHKRCNNFDNKILNHNNHKVE
Frame 2
GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAPPPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG
LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR
*FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG
QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP
TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL
RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR
TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG
RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC
CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH
QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT
SMKKLSLISTVQMYRTRLNNTYILARNLWANLL
F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST
GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG
ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG
SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM
LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK
GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS
*RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK*
TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER*
KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP
PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV
LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR
RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW
KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC
QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK
SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F
APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS
AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV
ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF
GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE
MDTASCFHQSHLLLLLVAATLLYSLRTYPPLRV
PLRIGPSPCHPSFVTEKTWIWQK*DTLTPTLTA
VLIDLPYSTQVILTWLLIPPSDPLLRLVSQAEVE
MDIRPS*ETQTRHFGQSST*CMPTPL*MLCLEQ
MDCIEDLL*WGIGSLYIWMGDIVPLQKDFPADM
NMA**KTSLVDPCHLVVKGPVKESHLPPRTHHRG
KKYPCWSTENGNKKLRKILLVGEVTLHRAKASL
QELGKAAVTPFPTLVPMVCRDPQPELHLPLTKN
SPHLIPLCPIWRR*AHQIPEALLHLTADLKRISA
VGGWFPHQ*NDSEKEGASPRSSEAA*GWPKRES
PLPHGRVTSQRKTQTLQMEKAQRH*AQHSLKEQ
QFTALPDTATSSCSVIVLGQNHKASFSRVPPPSE
DILHSLQDTVIELLH*DLETPPLTVLQNHPSLP
RPIPAPPTLCPQTRWPHLRGHQGILAASHILET
ALAAIFQGGAALLVLLALPCRDPQTRQPQIQFLS
PAQEL*VPPPFLRTLGRHCHQTYGLSVCPVLGS
QLSTRPPGYLRFPIHSTTHTVGVGVCTSTDSSH
CKGQESRLRRDFPRASGFGQTELNEPIAASFQLP
LEPRPSILLRNGGYKVPEDWVWWTRNKTCGHNW
PLALEKAVNLV*SRDYKEVSPCCQGYIVDKQMV
FRLVTVLSAMSCVEASVSHPCL*PVVTCAVRTSF
*I*KKKKKKFSKEKKLKEPISKPQAI*VLLGFY
ALKKKGRYVNVHPKTTIPKAGIWPMCVHQEYCL
SLS*DHQEIGKDSKAWNLHQLEGAWLFEEKLMVS
S*LFGSRLFE*IV*ASNCYHPTPPSQAISQLSN
P*SK*TRKGGMRHDIGQLHCYLPAFGNKFH*EG
YRVVWECFEFYFFYSQLIRS**SHEQDRLHDWGA
CTCDCRVRVGR*VCGVAPTGL*LCVGLPHISLG
DAYVRVGPVKELPSHPHP*HCSG*EMRADRLLP
ISALCLLYTPGGALEPAQVGYTIFLNSIWLPAYF
FHLFTVISGVFLFI*FCIQL*PW*G**IYDRCN
PWCCSGPSFLLDKIIL*VSLLPSL*FVFLFSPA
SCIPFFSTLSYNYHMHSLLSLCVTVTKFHFSKSK
SGVCSNEGRFFFFFFF*MLRPQQSTFLFVVSPT
NPSVWESIGSGNHVAWDAGFFVYYIKRM*MSLH
LGWGLHSPLGYLTKGRGQRAGGPHPAWHVQRPQP
LCVGRVLSRPDLLGG*GRGGGGNSWKGRSITSF
SSGVFTPCCNI*TFTRDVIILIIKFLTIIIIKL
R
Sequence XM_926615
GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC
CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT
AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG
TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT
ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA
GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG
AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA
AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT
GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA
CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC
AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT
TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC
CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC
ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT
CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT
GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA
GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT
AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA
GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG
AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC
CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT
GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA
AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA
AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG
TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG
AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG
CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG
CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA
GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG
GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA
AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG
ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC
CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC
TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG
GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC
CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT
GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC
AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG
AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC
AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAG
AAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGAC
AGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGA
AACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGG
GGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCT
GCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTG
CCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCAC
ACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGC
AAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGA
TTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTT
TCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATC
CTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCC
AATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAA
GCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACC
AACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTA
CCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCAT
TGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGA
GTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGAC
AGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAA
CACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGG
GGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCA
GTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCC
CTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCT
CTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCT
GAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACAAACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGT
TTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATTTGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGG
CAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGACCCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGG
GGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATA
ATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGAGAA
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
AAAARLRSETHAAPVPPVRQHSSAGPPLSLALPPLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA
*LESCRLPGVPCAAARAQAPAAPGTRSSELLAD
NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV
VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL
LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS
EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP
EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE
GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV
VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS
TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P
V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY
FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA
PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA
FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV
HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG
C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK
ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA
RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS
RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR
SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH
LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE
CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE
ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG
RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG
VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR
VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL
HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E
ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E**
LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS
ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS
KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG
FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL
PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ
LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW
GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG
L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF
CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA
GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ
RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP
QGPPKQREGGPKGRALSHMGE*HHRERLRPCRWR
RPRDIKLSTL*RSNSLQPFQIQLPAPAV**SSD
RITKPPSAEFLPLQRTSYTVSRIQLSNYCTETW
KPPLSRFFRIIPLFHVLFQPRPPCVHRLVGPIYG
DTRVF*QPATFWKQHWQQSSKEELPF*CC*PYP
AGTLRLANLRFSFSVQHRNSEFHLLSSEL*VVI
AIRLTDYQSAQCWAVSCLPGLQGICGFQFTALPT
PWEWGCAPVPTPATARVRSQDSDGTFLGLLDLG
KQN*MSP*LLPSSCLWNLGRAYC*GTGGTRCQR
IGSGGQETRLVVTIGLWPWRKL*ILSEAETIKKF
LPAVKGTLLTSKWCFG**RF*VQ*VVLKPPSPI
LACSP*SLVQ*GHLFKFKKKKKKSFQRKKS*KS
QSQSPKPSEYC*GFMHLRKKVGM*MFILRQPFQK
QVSGQCVSTKNTVYLCLKITKK*ARIVKLGTCT
NWRVPGSLKKSSWSALDYSGADYLSRLSEPPTV
TILLPLPKLFHSSVTHEVSRQEKEE*DMI*ANCI
ATYQLLAINFIRKDTEWFGNASNFIFSTPN*SG
VDDPMSRTASMIGEHALVTAG*EWEDRFVEWHR
QDCDCVWACPTFLWGMLM*EWAQ*KSYQATHTPN
TVLDER*EQTGFSPSVHCACCTPLEEPWSQPRW
GTQSF*IPYGCQLISFTCLL*YLACFYLSNFVF
SYNHGRGSEYMTGVIPGAAVDLLFFWTR*YCEFP
SFLPSNLFSFFPQPLASPSFLPCPTTIICTVFS
LCV*LLQNFTFQNRNQVFAQMRGDFFFFFFFKC
*DLSRVLFFLLFPPQTHQSGRALGVEIMLPGMLV
SLYII*NVCKCLSIWAGVCILPLAI*PRGEASG
QAALTLPGTCRDPSHSVWAGCCQDQTSWGGRGG
GVGGTLGREEVSLLSQVECLHLAVTFELSQEM**
F***NS*P**S*S*E
Frame 1
RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCPPSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG
PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI
IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW
SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS
YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ
RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP
NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG
KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL
YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA
PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD
QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI
LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH
RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG
HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF
IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD
AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK
RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL
EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV
DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV
EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT
SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS
VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP
KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE
EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV
SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ
ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC
TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK
RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS
SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR
PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR
NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL
DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS
LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN
LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD
GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA
CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS
AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV
QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR
GTSSSHCRPQENISSRWMVPTSVERLREGGSIP
KVLRSSVRVAQKGEPSPTWESNITEKDSDPADG
EGPETLSSALSKGATVYSPSRYSYQLLQCDSPRT
ESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPG
NPPSHGSSESSLSSTSYSSPAHPVSTDSLAPFT
GTPGYFSSQPHSGNSTGSNLPRRSCPSSAASPTL
QGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSL
PSDLRTISLPSAGQSAVYQASRVSAVSNSQHYP
HRGSGGVHQYRLQPLQGSGVKTQTGLS*GFWIWA
NRTE*AHSCFLPAASGT*AEHIAEERGVQGARG
LGLVDKKQDLWSQLASGLGESCKSCLKQRL*RS
FSLLSRVHC*QANGVSVSNGSKCNELC*SLRLPS
LPVARSHLCSEDIFLNLKKKKKKVFKGKKVKRA
NLKAPSHLSTVRVLCT*EKR*VCKCSS*DNHSK
SRYLANVCPPRILFIFVLRSPRNRQG**SLEPAP
TGGCLAL*RKAHGQLLIIREQII*VDCLSLQLL
PSYSPFPSYFTAQ*PMK*VDKKRRNET*YRPIA
LLLTSFWQ*ISLGRIPSGLGMLRILFFLLPINQE
LMIP*AGPPP*LGSMHL*LQGKSGKIGLWSGTD
RTVIVCGPAPHFSGGCLCESGPSERVTKPPTPL
TLFWMRDESRPASPHQCIVPVVHPWRSPGASPGG
VHNLFKFHMVASLFLSLVYCNIWRVFIYLILYS
VITMVGVVNI*QV*SLVLQWTFFSFGQDNTVSF
PPSFPLICFPFFPSLLHPLLFYPVLQLSYAQSSL
FVCDCYKISLFKIEIRCLLK*GEIFFFFFFLNA
ETSAEYFSFCCFPHKPISLGEHWEWKSCCLGCW
FLCILYKTYVNVSPFGLGFAFSPWLFNQGERPAG
RRPSPCLARAETPATLCGQGAVKTRPLGGVGAG
GWGELLEGKKYHFFLKWSVYTLL*HLNFHKRCN
NFDNKILNHNNHKVE
Frame 2
GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAPPPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG
LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR
*FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG
QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP
TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL
RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR
TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG
RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC
CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH
QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT
SMKKLSLISTVQMYRTRLNNTYILARNLWANLL
F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST
GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG
ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG
SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM
LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK
GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS
*RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK*
TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER*
KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP
PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV
LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR
RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW
KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC
QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK
SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F
APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS
AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV
ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF
GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE
MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW
IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP
PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST
*CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM
GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG
PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL
LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC
RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP
EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP
RSSEAA*GWPKRESPLPHGRVTSQRKTQTLQME
KAQRH*AQHSLKEQQFTALPDTATSSCSVIVLG
QNHKASFSRVPPPSEDILHSLQDTVIELLH*DLE
TPPLTVLQNHPSLPRPIPAPPTLCPQTRWPHLR
GHQGILAASHILETALAAIFQGGAALLVLLALP
CRDPQTRQPQIQFLSPAQEL*VPPPFLRTLGRHC
HQTYGLSVCPVLGSQLSTRPPGYLRFPIHSTTH
TVGVGVCTSTDSSHCKGQESRLRRDFPRASGFG
QTELNEPIAASFQLPLEPRPSILLRNGGYKVPED
WVWWTRNKTCGHNWPLALEKAVNLV*SRDYKEV
SPCCQGYIVDKQMVFRLVTVLSAMSCVEASVSH
PCL*PVVTCAVRTSF*I*KKKKKKFSKEKKLKEP
ISKPQAI*VLLGFYALKKKGRYVNVHPKTTIPK
AGIWPMCVHQEYCLSLS*DHQEIGKDSKAWNLH
QLEGAWLFEEKLMVSS*LFGSRLFE*IV*ASNCY
HPTPPSQAISQLSNP*SK*TRKGGMRHDIGQLH
CYLPAFGNKFH*EGYRVVWECFEFYFFYSQLIR
S**SHEQDRLHDWGACTCDCRVRVGR*VCGVAPT
GL*LCVGLPHISLGDAYVRVGPVKELPSHPHP*
HCSG*EMRADRLLPISALCLLYTPGGALEPAQV
GYTIFLNSIWLPAYFFHLFTVISGVFLFI*FCIQ
L*PW*G**IYDRCNPWCCSGPSFLLDKIIL*VS
LLPSL*FVFLFSPASCIPFFSTLSYNYHMHSLL
SLCVTVTKFHFSKSKSGVCSNEGRFFFFFFF*ML
RPQQSTFLFVVSPTNPSVWESIGSGNHVAWDAG
FFVYYIKRM*MSLHLGWGLHSPLGYLTKGRGQR
AGGPHPAWHVQRPQPLCVGRVLSRPDLLGG*GRG
GGGNSWKGRSITSFSSGVFTPCCNI*TFTRDVI
ILIIKFLTIIIIKLR
Sequence XM_931444
GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC
CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT
AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG
TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT
ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA
GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG
AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA
AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT
GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA
CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC
AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT
TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC
CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC
ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT
CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT
GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA
GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT
AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA
GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG
AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC
CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT
GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA
AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA
AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG
TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG
AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG
CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG
CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA
GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG
GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA
AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG
ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC
CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC
TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG
GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC
CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT
GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC
AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG
AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC
AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGGTGAGCCCATGGCCT
TCTGCTGCCACCACATTCAGGGACACATGAGCCGAGTCCTGTACAGTTCATGCCTAGTGCTGAGTTGAGGTGAGTCAGTTTCTGATGCAGTTGGGCTCCA
CCGCATGCTAGGTTCCAGCCCACTTATGCTCATTTGGGCTACCACATTTGTAAGATCTAGCATTGCTTGCTCTCTGTCTGCTCTTTTTTCCCCAAGGAAT
ACCTTTCTGTAACTCTCATCTCTCCAAAGTCCTGGAAATCTACCTCGATGAAGGATGAAGAGAAAGAAGACGGGAATCACATCAGGCATTTAGAACATAG
CCCATAATTAACCACTCATTTTGCCCTTCTGGCATGCTGCACTCACCCAATTTGTCACAAAGAGAGCAGTACGGGTTGGTGATGGCACTGGTGATTTAAA
TGAAAAATGGCTCTTTCTTACTTATTCTAAGAAGCCAAGTTGATTTTTTTTTATATATGTTACCTTCCAGACCCTGCAGATGGAGAAGGCCCAGAGACAT
TAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGGTGAGATGAGAAATTGCTGGTCTCTAGCCATAGGAGTGTGT
TCTGGGTCCCAAATTGTCCTGGTCATCCTTTGCCATTGAGATGCTGTCTTTGCATATAGTTTCAGCAGCCTTGGAAATAAGTCATCATCTGCTTGTCCTC
AGGTAATAAATTATGCCAGAAGATGAATACGGTGATCAAAGACAGACATTTTACTGCCTTTGGTTTCCTAAAAAGAATACATGGTTAAAAGATGAAGAAA
AAAGAATGTAGGGTATTATAAATGTTCACCAGCCATTTAAGGGACTTGTTCGCGTCCTTATTCGTTTCCTCCCAACTTTGTCTAGCTCCTGCAGTGTGAT
AGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCAC
TGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGC
CCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCT
AGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTA
GGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACA
GCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTC
TGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAG
GTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACT
ATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTC
CGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAG
TTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAA
CCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTG
GAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCC
TCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAG
GCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCA
ATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGA
GTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACC
CACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCC
AGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAA
TTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATAC
TGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCT
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
AAAARLRSETHAAPVPPVRQHSSAGPPLSLALPPLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA
*LESCRLPGVPCAAARAQAPAAPGTRSSELLAD
NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV
VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL
LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS
EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP
EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE
GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV
VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS
TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P
V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY
FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA
PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA
FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV
HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG
C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK
ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA
RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS
RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR
SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH
LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE
CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE
ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG
RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG
VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR
VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL
HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E
ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E**
LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS
ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS
KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG
FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL
PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ
LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW
GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG
L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF
CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA
GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ
RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP
QGPPKQREGGPKGRALSHMGE*HHRERLR*AHGL
LLPPHSGTHEPSPVQFMPSAELR*VSF*CSWAP
PHARFQPTYAHLGYHICKI*HCLLSVCSFFPKE
YLSVTLISPKSWKSTSMKDEEKEDGNHIRHLEHS
P*LTTHFALLACCTHPICHKESSTGW*WHW*FK
*KMALSYLF*EAKLIFFYICYLPDPADGEGPET
LSSALSKGATVYSPSRYSYQVR*EIAGL*P*ECV
LGPKLSWSSFAIEMLSLHIVSAALEISHHLLVL
R**IMPEDEYGDQRQTFYCLWFPKKNTWLKDEE
KRM*GIINVHQPFKGLVRVLIRFLPTLSSSCSVI
VLGQNHKASFSRVPPPSEDILHSLQDTVIELLH
*DLETPPLTVLQNHPSLPRPIPAPPTLCPQTRW
PHLRGHQGILAASHILETALAAIFQGGAALLVLL
ALPCRDPQTRQPQIQFLSPAQEL*VPPPFLRTL
GRHCHQTYGLSVCPVLGSQLSTRPPGYLRFPIH
STTHTVGVGVCTSTDSSHCKGQESRLRRDFPRAS
GFGQTELNEPIAASFQLPLEPRPSILLRNGGYK
VPEDWVWWTRNKTCGHNWPLALEKAVNLV*SRD
YKEVSPCCQGYIVDKQMVFRLVTVLSAMSCVEAS
VSHPCL*PVVTCAVRTSF*I*KKKKKKFSKEKK
LKEPISKPQAI*VLLGFYALKKKGRYVNVHPKT
TIPKAGIWPMCVHQEYCLSLS*DHQEIGKDSKAW
NLHQLEGAWLFEEKLMVSS*LFGSRLFE*IV*A
SNCYHPTPPSQAISQLSNP*SK*TRKGGMRHDI
GQLHCYLPAFGNKFH*EGYRVVWECFEFYFFYSQ
LIRS**SHEQDRLHDWGACTCDCRVRVGR*VCG
VAPTGL*LCVGLPHISLGDAYVRVGPVKELPSH
PHP*HCSG*EMRADRLLPISALCLLYTPGGALEP
AQVGYTIFLNSIWLPAYFFHLFTVISGVFLFI*
FCIQL*PW*G**IYDRCNPWCCSGPSFLLDKII
L*VSLLPSL*FVFLFSPASCIPFFST
Frame 1
RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCPPSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG
PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI
IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW
SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS
YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ
RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP
NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG
KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL
YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA
PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD
QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI
LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH
RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG
HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF
IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD
AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK
RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL
EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV
DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV
EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT
SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS
VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP
KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE
EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV
SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ
ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC
TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK
RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS
SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR
PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR
NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL
DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS
LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN
LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD
GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA
CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS
AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV
QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR
GTSSSHCRPQENISSRWMVPTSVERLREGGSIP
KVLRSSVRVAQKGEPSPTWESNITEKDSGEPMA
FCCHHIQGHMSRVLYSSCLVLS*GESVSDAVGLH
RMLGSSPLMLIWATTFVRSSIACSLSALFSPRN
TFL*LSSLQSPGNLPR*RMKRKKTGITSGI*NI
AHN*PLILPFWHAALTQFVTKRAVRVGDGTGDLN
EKWLFLTYSKKPS*FFFIYVTFQTLQMEKAQRH
*AQHSLKEQQFTALPDTATR*DEKLLVSSHRSV
FWVPNCPGHPLPLRCCLCI*FQQPWK*VIICLSS
GNKLCQKMNTVIKDRHFTAFGFLKRIHG*KMKK
KECRVL*MFTSHLRDLFASLFVSSQLCLAPAV*
*SSDRITKPPSAEFLPLQRTSYTVSRIQLSNYCT
ETWKPPLSRFFRIIPLFHVLFQPRPPCVHRLVG
PIYGDTRVF*QPATFWKQHWQQSSKEELPF*CC
*PYPAGTLRLANLRFSFSVQHRNSEFHLLSSEL*
VVIAIRLTDYQSAQCWAVSCLPGLQGICGFQFT
ALPTPWEWGCAPVPTPATARVRSQDSDGTFLGL
LDLGKQN*MSP*LLPSSCLWNLGRAYC*GTGGTR
CQRIGSGGQETRLVVTIGLWPWRKL*ILSEAET
IKKFLPAVKGTLLTSKWCFG**RF*VQ*VVLKP
PSPILACSP*SLVQ*GHLFKFKKKKKKSFQRKKS
*KSQSQSPKPSEYC*GFMHLRKKVGM*MFILRQ
PFQKQVSGQCVSTKNTVYLCLKITKK*ARIVKL
GTCTNWRVPGSLKKSSWSALDYSGADYLSRLSEP
PTVTILLPLPKLFHSSVTHEVSRQEKEE*DMI*
ANCIATYQLLAINFIRKDTEWFGNASNFIFSTP
N*SGVDDPMSRTASMIGEHALVTAG*EWEDRFVE
WHRQDCDCVWACPTFLWGMLM*EWAQ*KSYQAT
HTPNTVLDER*EQTGFSPSVHCACCTPLEEPWS
QPRWGTQSF*IPYGCQLISFTCLL*YLACFYLSN
FVFSYNHGRGSEYMTGVIPGAAVDLLFFWTR*Y
CEFPSFLPSNLFSFFPQPLASPSFLP
Frame 2
GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAPPPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG
LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR
*FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG
QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP
TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL
RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR
TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG
RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC
CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH
QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT
SMKKLSLISTVQMYRTRLNNTYILARNLWANLL
F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST
GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG
ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG
SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM
LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK
GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS
*RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK*
TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER*
KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP
PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV
LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR
RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW
KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC
QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK
SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F
APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS
AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV
ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF
GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE
MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW
IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP
PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST
*CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM
GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG
PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL
LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC
RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP
EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP
RSSEAA*GWPKRESPLPHGRVTSQRKTQVSPWP
SAATTFRDT*AESCTVHA*C*VEVSQFLMQLGS
TAC*VPAHLCSFGLPHL*DLALLALCLLFFPQGI
PFCNSHLSKVLEIYLDEG*RERRRESHQAFRT*
PIINHSFCPSGMLHSPNLSQREQYGLVMALVI*
MKNGSFLLILRSQVDFFLYMLPSRPCRWRRPRDI
KLSTL*RSNSLQPFQIQLPGEMRNCWSLAIGVC
SGSQIVLVILCH*DAVFAYSFSSLGNKSSSACP
QVINYARR*IR*SKTDILLPLVS*KEYMVKR*RK
KNVGYYKCSPAI*GTCSRPYSFPPNFV*LLQCD
SPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTA
LRPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLA
PFTGTPGYFSSQPHSGNSTGSNLPRRSCPSSAA
SPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNS
RSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQ
HYPHRGSGGVHQYRLQPLQGSGVKTQTGLS*GF
WIWANRTE*AHSCFLPAASGT*AEHIAEERGVQ
GARGLGLVDKKQDLWSQLASGLGESCKSCLKQRL
*RSFSLLSRVHC*QANGVSVSNGSKCNELC*SL
RLPSLPVARSHLCSEDIFLNLKKKKKKVFKGKK
VKRANLKAPSHLSTVRVLCT*EKR*VCKCSS*DN
HSKSRYLANVCPPRILFIFVLRSPRNRQG**SL
EPAPTGGCLAL*RKAHGQLLIIREQII*VDCLS
LQLLPSYSPFPSYFTAQ*PMK*VDKKRRNET*YR
PIALLLTSFWQ*ISLGRIPSGLGMLRILFFLLP
INQELMIP*AGPPP*LGSMHL*LQGKSGKIGLW
SGTDRTVIVCGPAPHFSGGCLCESGPSERVTKPP
TPLTLFWMRDESRPASPHQCIVPVVHPWRSPGA
SPGGVHNLFKFHMVASLFLSLVYCNIWRVFIYL
ILYSVITMVGVVNI*QV*SLVLQWTFFSFGQDNT
VSFPPSFPLICFPFFPSLLHPLLFYP
Sequence XM_931447
GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC
CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT
AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG
TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT
ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA
GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG
AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA
AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT
GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA
CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC
AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT
TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC
CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC
ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT
CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT
GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA
GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT
AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA
GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG
AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC
CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT
GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA
AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA
AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG
TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG
AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG
CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG
CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA
GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG
GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA
AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG
ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC
CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC
TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG
GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC
CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT
GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC
AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG
AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC
AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAG
AAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGGTGAGATGAGAAATTGCTGGTCTCTA
GCCATAGGAGTGTGTTCTGGGTCCCAAATTGTCCTGGTCATCCTTTGCCATTGAGATGCTGTCTTTGCATATAGTTTCAGCAGCCTTGGAAATAAGTCAT
CATCTGCTTGTCCTCAGGTAATAAATTATGCCAGAAGATGAATACGGTGATCAAAGACAGACATTTTACTGCCTTTGGTTTCCTAAAAAGAATACATGGT
TAAAAGATGAAGAAAAAAGAATGTAGGGTATTATAAATGTTCACCAGCCATTTAAGGGACTTGTTCGCGTCCTTATTCGTTTCCTCCCAACTTTGTCTAG
CTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTT
ATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTC
CACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGC
CCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCT
TTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGC
GGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGA
CTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGG
AACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTG
TCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAG
TTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTT
TCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATG
TTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAA
GGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAG
TAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAA
TGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTA
TTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGA
AGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAG
AGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGG
AGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTG
TTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTT
TGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCT
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
AAAARLRSETHAAPVPPVRQHSSAGPPLSLALPPLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA
*LESCRLPGVPCAAARAQAPAAPGTRSSELLAD
NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV
VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL
LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS
EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP
EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE
GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV
VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS
TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P
V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY
FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA
PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA
FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV
HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG
C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK
ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA
RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS
RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR
SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH
LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE
CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE
ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG
RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG
VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR
VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL
HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E
ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E**
LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS
ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS
KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG
FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL
PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ
LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW
GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG
L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF
CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA
GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ
RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP
QGPPKQREGGPKGRALSHMGE*HHRERLRPCRWR
RPRDIKLSTL*RSNSLQPFQIQLPGEMRNCWSL
AIGVCSGSQIVLVILCH*DAVFAYSFSSLGNKS
SSACPQVINYARR*IR*SKTDILLPLVS*KEYMV
KR*RKKNVGYYKCSPAI*GTCSRPYSFPPNFV*
LLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYS
YRTTALRPGNPPSHGSSESSLSSTSYSSPAHPVS
TDSLAPFTGTPGYFSSQPHSGNSTGSNLPRRSC
PSSAASPTLQGPSDSPTSDSVSQSSTGTLSSTS
FPQNSRSSLPSDLRTISLPSAGQSAVYQASRVSA
VSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTG
LS*GFWIWANRTE*AHSCFLPAASGT*AEHIAE
ERGVQGARGLGLVDKKQDLWSQLASGLGESCKSC
LKQRL*RSFSLLSRVHC*QANGVSVSNGSKCNE
LC*SLRLPSLPVARSHLCSEDIFLNLKKKKKKV
FKGKKVKRANLKAPSHLSTVRVLCT*EKR*VCKC
SS*DNHSKSRYLANVCPPRILFIFVLRSPRNRQ
G**SLEPAPTGGCLAL*RKAHGQLLIIREQII*
VDCLSLQLLPSYSPFPSYFTAQ*PMK*VDKKRRN
ET*YRPIALLLTSFWQ*ISLGRIPSGLGMLRIL
FFLLPINQELMIP*AGPPP*LGSMHL*LQGKSG
KIGLWSGTDRTVIVCGPAPHFSGGCLCESGPSER
VTKPPTPLTLFWMRDESRPASPHQCIVPVVHPW
RSPGASPGGVHNLFKFHMVASLFLSLVYCNIWR
VFIYLILYSVITMVGVVNI*QV*SLVLQWTFFSF
GQDNTVSFPPSFPLICFPFFPSLLHPLLFYP
Frame 1
RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCPPSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG
PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI
IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW
SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS
YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ
RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP
NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG
KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL
YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA
PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD
QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI
LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH
RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG
HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF
IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD
AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK
RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL
EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV
DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV
EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT
SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS
VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP
KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE
EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV
SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ
ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC
TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK
RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS
SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR
PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR
NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL
DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS
LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN
LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD
GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA
CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS
AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV
QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR
GTSSSHCRPQENISSRWMVPTSVERLREGGSIP
KVLRSSVRVAQKGEPSPTWESNITEKDSDPADG
EGPETLSSALSKGATVYSPSRYSYQVR*EIAGL*
P*ECVLGPKLSWSSFAIEMLSLHIVSAALEISH
HLLVLR**IMPEDEYGDQRQTFYCLWFPKKNTW
LKDEEKRM*GIINVHQPFKGLVRVLIRFLPTLSS
SCSVIVLGQNHKASFSRVPPPSEDILHSLQDTV
IELLH*DLETPPLTVLQNHPSLPRPIPAPPTLC
PQTRWPHLRGHQGILAASHILETALAAIFQGGAA
LLVLLALPCRDPQTRQPQIQFLSPAQEL*VPPP
FLRTLGRHCHQTYGLSVCPVLGSQLSTRPPGYL
RFPIHSTTHTVGVGVCTSTDSSHCKGQESRLRRD
FPRASGFGQTELNEPIAASFQLPLEPRPSILLR
NGGYKVPEDWVWWTRNKTCGHNWPLALEKAVNL
V*SRDYKEVSPCCQGYIVDKQMVFRLVTVLSAMS
CVEASVSHPCL*PVVTCAVRTSF*I*KKKKKKF
SKEKKLKEPISKPQAI*VLLGFYALKKKGRYVN
VHPKTTIPKAGIWPMCVHQEYCLSLS*DHQEIGK
DSKAWNLHQLEGAWLFEEKLMVSS*LFGSRLFE
*IV*ASNCYHPTPPSQAISQLSNP*SK*TRKGG
MRHDIGQLHCYLPAFGNKFH*EGYRVVWECFEFY
FFYSQLIRS**SHEQDRLHDWGACTCDCRVRVG
R*VCGVAPTGL*LCVGLPHISLGDAYVRVGPVK
ELPSHPHP*HCSG*EMRADRLLPISALCLLYTPG
GALEPAQVGYTIFLNSIWLPAYFFHLFTVISGV
FLFI*FCIQL*PW*G**IYDRCNPWCCSGPSFL
LDKIIL*VSLLPSL*FVFLFSPASCIPFFST
Frame 2
GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAPPPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG
LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR
*FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG
QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP
TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL
RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR
TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG
RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC
CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH
QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT
SMKKLSLISTVQMYRTRLNNTYILARNLWANLL
F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST
GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG
ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG
SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM
LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK
GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS
*RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK*
TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER*
KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP
PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV
LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR
RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW
KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC
QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK
SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F
APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS
AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV
ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF
GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE
MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW
IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP
PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST
*CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM
GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG
PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL
LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC
RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP
EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP
RSSEAA*GWPKRESPLPHGRVTSQRKTQTLQME
KAQRH*AQHSLKEQQFTALPDTATR*DEKLLVS
SHRSVFWVPNCPGHPLPLRCCLCI*FQQPWK*VI
ICLSSGNKLCQKMNTVIKDRHFTAFGFLKRIHG
*KMKKKECRVL*MFTSHLRDLFASLFVSSQLCL
APAV**SSDRITKPPSAEFLPLQRTSYTVSRIQL
SNYCTETWKPPLSRFFRIIPLFHVLFQPRPPCV
HRLVGPIYGDTRVF*QPATFWKQHWQQSSKEEL
PF*CC*PYPAGTLRLANLRFSFSVQHRNSEFHLL
SSEL*VVIAIRLTDYQSAQCWAVSCLPGLQGIC
GFQFTALPTPWEWGCAPVPTPATARVRSQDSDG
TFLGLLDLGKQN*MSP*LLPSSCLWNLGRAYC*G
TGGTRCQRIGSGGQETRLVVTIGLWPWRKL*IL
SEAETIKKFLPAVKGTLLTSKWCFG**RF*VQ*
VVLKPPSPILACSP*SLVQ*GHLFKFKKKKKKSF
QRKKS*KSQSQSPKPSEYC*GFMHLRKKVGM*M
FILRQPFQKQVSGQCVSTKNTVYLCLKITKK*A
RIVKLGTCTNWRVPGSLKKSSWSALDYSGADYLS
RLSEPPTVTILLPLPKLFHSSVTHEVSRQEKEE
*DMI*ANCIATYQLLAINFIRKDTEWFGNASNF
IFSTPN*SGVDDPMSRTASMIGEHALVTAG*EWE
DRFVEWHRQDCDCVWACPTFLWGMLM*EWAQ*K
SYQATHTPNTVLDER*EQTGFSPSVHCACCTPL
EEPWSQPRWGTQSF*IPYGCQLISFTCLL*YLAC
FYLSNFVFSYNHGRGSEYMTGVIPGAAVDLLFF
WTR*YCEFPSFLPSNLFSFFPQPLASPSFLP
Sequence XM_931478
GAGTGTAATCCATTCTTATACATTGTGACTTTCTTGAAATGTTTATATGCAGCATGACGAAGTTGCCCCTTTTGCACTTCCCTGACTCCAGCGGACGTCTAGCCCTGCATCATTGTTCTTGTTTTTATGTCCCAGTTGACCTTGGCATTTTGTTTTATCACTTTCCTGGTTGAAGCCAAAAAACAAAGGGTACTACTTTC
TTCTTTCTTTCCATATGTACCATACTTTAGGGGAGAGAGGGGCCAGTGTTTGGACACTGTTGATTTAAAAAATCTTATTTTCAGGATCATAATTACGGAG
CCCCTCCTCCTCCGACACCTCCTGCTTCTCCCCCTGTCCAGACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGG
AGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATG
AGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTT
CCACTGTGTTGTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGG
TCGTGCAGCACCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTA
TGGACTGACCAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCA
AACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGT
TCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAG
GTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATG
ATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCAT
CACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCT
ATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGAC
GGAAAGAGCTAGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCA
TGAGGAAGTAGACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGAT
AGAAAGGTAGAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTA
CTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCAC
CCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGG
CCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAG
CTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCC
AACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCA
GAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCC
CGTTAATTTGCACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTC
CTGTAAGAAGCGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAAT
GAGAATAGTAGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCA
AGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGA
GGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGA
AAAGACCTGGATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTC
CTCATCCCTCCCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGAC
AGAGTTCAACTTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTA
CATTTGGATGGGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTG
GTGAAAGGGCCTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAA
GGAAAATTCTGCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCC
CATGGTGTGCAGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCAT
CAGATTCCAGAGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGG
GAGCATCCCCAAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCT
GCAGATGGAGAAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATA
GTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACT
GAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCC
CCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTA
GCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAG
GTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAG
CACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCT
GGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGG
TGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTA
TAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCC
GTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGT
TAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAAC
CATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGG
AACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCT
CCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGG
CCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAA
TTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAG
TGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCC
ACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCA
GCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAAT
TTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACT
GTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCAC
AGTCTTCTCTCTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTT
TTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACAAACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTG
GGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATTTGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGA
GGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGACCCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGT
AGGGGCGGGGGGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAG
AGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGAGAA
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
ECNPFLYIVTFLKCLYAA*RSCPFCTSLTPADV*PCIIVLVFMSQLTLAFCFITFLVEAKKQRVLLS
SFFPYVPYFRGERGQCLDTVDLKNLIFRIIITE
PLLLRHLLLLPLSRRSSLVLT*MACRRL*RNAV
ETARTLKEKLYLPGVLVVFLRMASFSTVTSAGE*
AGGRLLDFIGGSRTTYQVGIAVQQKAGMRSFLL
PLCCIQQHSTHLQASP*LLEEPNPRSGKRVQKR
VVQHQRRRKSRILPLKHRI*MRIQLRAGKIG*DY
GLTSMKKLSLISTVQMYRTRLNNTYILARNLWA
NLLF*TLLIRLNWPVITQLLVPKCSYSWEESLV
FKSTGRS*GLQEIWLWTLL**SIVGKSCYDSNLR
SMGISSKNHTPLCSSTQNSMV*RCVWMPVLSVM
MLGSSEDHVHQMQRCDT*LQMG*FTCASMLCLP
SPRMLRSP*HLIMSIVTVIIKWTVPVTRETGIVL
YKKGILMLQNCHSYHLLQAYPPLEQRLDVEKHD
GKS*RWSSRMRLQRRIMTSNHKKFQKK*LYPVI
MRK*TIQKKNQKKRKKRL*MTRRT*LIAGGPGKI
ER*KPSCMLLKT*RKERSGGISPWNRATLM*RL
LQPPQRLLLVKRQKLKPLNLKLATLFQMLPSQA
PHRVLV*IPGGLPKQGILLQKN*SPSHLQQSLLG
PGRRVEFLGTGPVQPKD*SVRSRPMHSRQNCHK
LPWKREEVTV**LLLKLEV*TVQEKTGH*QGLT
QLWCQLLDPMSTVLHLNTPKPKSI*LQNG*MTKQ
RSKSALLSALYVSQRIQLYWQRP*TCYQVLSIP
R*FAPPPNTTFALAHPLSLRDVEGPFCLMAHSA
PVRSAG*NKP*KKG*LKHHLYPKRLELSTYTKAM
RIVALLVSAKTMQTC*AH*RNGSLAI*WSRMSP
SYFGLCLQSHHPLPIQAQRVPSWPHLAHLTQEK
RSVEMDTASCFHQSHLLLLLVAATLLYSLSFVTE
KTWIWQK*DTLTPTLTAVLIDLPYSTQVILTWL
LIPPSDPLLRLVSQAEVEMDIRPS*ETQTRHFG
QSST*CMPTPL*MLCLEQMDCIEDLL*WGIGSLY
IWMGDIVPLQKDFPADMNMA**KTSLVDPCHLV
VKGPVKESHLPPRTHHRGKKYPCWSTENGNKKL
RKILLVGEVTLHRAKASLQELGKAAVTPFPTLVP
MVCRDPQPELHLPLTKNSPHLIPLCPIWRR*AH
QIPEALLHLTADLKRISAVGGWFPHQ*NDSEKE
GASPRSSEAA*GWPKRESPLPHGRVTSQRKTQTL
QMEKAQRH*AQHSLKEQQFTALPDTATSSCSVI
VLGQNHKASFSRVPPPSEDILHSLQDTVIELLH
*DLETPPLTVLQNHPSLPRPIPAPPTLCPQTRWP
HLRGHQGILAASHILETALAAIFQGGAALLVLL
ALPCRDPQTRQPQIQFLSPAQEL*VPPPFLRTL
GRHCHQTYGLSVCPVLGSQLSTRPPGYLRFPIHS
TTHTVGVGVCTSTDSSHCKGQESRLRRDFPRAS
GFGQTELNEPIAASFQLPLEPRPSILLRNGGYK
VPEDWVWWTRNKTCGHNWPLALEKAVNLV*SRDY
KEVSPCCQGYIVDKQMVFRLVTVLSAMSCVEAS
VSHPCL*PVVTCAVRTSF*I*KKKKKKFSKEKK
LKEPISKPQAI*VLLGFYALKKKGRYVNVHPKTT
IPKAGIWPMCVHQEYCLSLS*DHQEIGKDSKAW
NLHQLEGAWLFEEKLMVSS*LFGSRLFE*IV*A
SNCYHPTPPSQAISQLSNP*SK*TRKGGMRHDIG
QLHCYLPAFGNKFH*EGYRVVWECFEFYFFYSQ
LIRS**SHEQDRLHDWGACTCDCRVRVGR*VCG
VAPTGL*LCVGLPHISLGDAYVRVGPVKELPSHP
HP*HCSG*EMRADRLLPISALCLLYTPGGALEP
AQVGYTIFLNSIWLPAYFFHLFTVISGVFLFI*
FCIQL*PW*G**IYDRCNPWCCSGPSFLLDKIIL
*VSLLPSL*FVFLFSPASCIPFFSTLSYNYHMH
SLLSLCVTVTKFHFSKSKSGVCSNEGRFFFFFF
F*MLRPQQSTFLFVVSPTNPSVWESIGSGNHVAW
DAGFFVYYIKRM*MSLHLGWGLHSPLGYLTKGR
GQRAGGPHPAWHVQRPQPLCVGRVLSRPDLLGG
*GRGGGGNSWKGRSITSFSSGVFTPCCNI*TFTR
DVIILIIKFLTIIIIKLR
Frame 1
SVIHSYTL*LS*NVYMQHDEVAPFALP*LQRTSSPASLFLFLCPS*PWHFVLSLSWLKPKNKGYYF
LLSFHMYHTLGERGASVWTLLI*KILFSGS*LRS
PSSSDTSCFSPCPDDHPSF*PEWPAVACRGTLW
RQPEL*RRNCTYLVSLWSFSGWLPSQL*QVQGN
EQGEGY*TSSAEAGQHIRWG*QCNRKLG*GAFSF
HCVVYSNTAHTYKHHLNC*KNQTQEAEKESRKG
SCSTKDEENQEFSL*STEFR*EYN*GLGKSDKT
MD*PV*RSFH*SVQCRCTERA*TTPTF*QGICGQ
TYYFRHY**D*IGL**HSYWFPNAVTAGKSHSC
SKAPEDPEGCKRFGFGHSYNRVSWESHVTTAI*
GQWAFLQKTIPLCALLLKIQWCRDVCGCPYFR**
CSVHQKIMYTKCRGATHDCRWDDSPVHLCCVCH
HQGC*GHHSI*L*V**L*L*SGLCLSQGKPELS
YTKKES*CYRTATPTTSSKPTHHWSRD*T*KSTT
ERARDGAAE*GFRGE**PAITRSSRKSNCIQ*S
*GSRQSRRKTRRRERRGYR*PGEPSS*QEDQGR
*KGRSHHACF*KLREKKEAAGSALGTEQL*CRDY
YNHLRDSCW*RDKN*SP*I*S*QLCFKCYHPKH
PTECWCEYPEVFPSRGYCCRKTSPQATSSKAF*
APAEESNFSVQDQFSPKTKASEAGQCTAGRIVTS
CLGRGRK*QFSNSY*SWKSRQFRRKQAINRV*P
NCGVNYWIPCQPCCI*IPQNQKVSSYRMVE*QS
REARVPC*VPFTYHNGSNCTGNDPKHVTRSYPFP
VNLHHPQTLHSLWLTLYP*ETSKAPSA*WHIQL
L*EALDKTSLRRRDDSNIICTPRD*NSAPIPKQ
*E**LF*YLQRQCRLVEPIKEMEVSLSDGAECHQ
VTSASVSSHTTPSQFRLKESPAGHTWLISPRRR
GVSKWIQPHVFTSHISYYC*SLQHSSTV*ALSP
KRPGFGKSRIP*LQH*QLC**TFPTQLRSF*PGS
SSLPRTHF*DWFPKQKWRWTSDPREKLRPGISD
RVQLDVCLLPFECYASSRWTVSRISSSGG*EAF
TFGWGILFPCRRIFQQI*TWLNERPLSWILVTWW
*KGL*RSPICPPEPTTEEKSIPAGVPKTETRS*
GKFCWWGR*LCTEQKQVCRSWARQQ*LRFRHWC
PWCAGILSPNSIFPSQKILPISFLYVPFGGGKPI
RFQRHFFISLQTSREYQQ*VDGSHISRTTPRRR
EHPQGPPKQREGGPKGRALSHMGE*HHRERLRP
CRWRRPRDIKLSTL*RSNSLQPFQIQLPAPAV**
SSDRITKPPSAEFLPLQRTSYTVSRIQLSNYCT
ETWKPPLSRFFRIIPLFHVLFQPRPPCVHRLVG
PIYGDTRVF*QPATFWKQHWQQSSKEELPF*CC*
PYPAGTLRLANLRFSFSVQHRNSEFHLLSSEL*
VVIAIRLTDYQSAQCWAVSCLPGLQGICGFQFT
ALPTPWEWGCAPVPTPATARVRSQDSDGTFLGLL
DLGKQN*MSP*LLPSSCLWNLGRAYC*GTGGTR
CQRIGSGGQETRLVVTIGLWPWRKL*ILSEAET
IKKFLPAVKGTLLTSKWCFG**RF*VQ*VVLKPP
SPILACSP*SLVQ*GHLFKFKKKKKKSFQRKKS
*KSQSQSPKPSEYC*GFMHLRKKVGM*MFILRQ
PFQKQVSGQCVSTKNTVYLCLKITKK*ARIVKLG
TCTNWRVPGSLKKSSWSALDYSGADYLSRLSEP
PTVTILLPLPKLFHSSVTHEVSRQEKEE*DMI*
ANCIATYQLLAINFIRKDTEWFGNASNFIFSTPN
*SGVDDPMSRTASMIGEHALVTAG*EWEDRFVE
WHRQDCDCVWACPTFLWGMLM*EWAQ*KSYQAT
HTPNTVLDER*EQTGFSPSVHCACCTPLEEPWSQ
PRWGTQSF*IPYGCQLISFTCLL*YLACFYLSN
FVFSYNHGRGSEYMTGVIPGAAVDLLFFWTR*Y
CEFPSFLPSNLFSFFPQPLASPSFLPCPTTIICT
VFSLCV*LLQNFTFQNRNQVFAQMRGDFFFFFF
FKC*DLSRVLFFLLFPPQTHQSGRALGVEIMLP
GMLVSLYII*NVCKCLSIWAGVCILPLAI*PRGE
ASGQAALTLPGTCRDPSHSVWAGCCQDQTSWGG
RGGGVGGTLGREEVSLLSQVECLHLAVTFELSQ
EM**F***NS*P**S*S*E
Frame 2
V*SILIHCDFLEMFICSMTKLPLLHFPDSSGRLALHHCSCFYVPVDLGILFYHFPG*SQKTKGTTF
FFLSICTIL*GREGPVFGHC*FKKSYFQDHNYG
APPPPTPPASPPVQTIIPRSDLNGLPSPVEERCG
DSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGM
SRGKVIRLHRRKQDNISGGDSSATESWDEELSP
STVLYTATQHTPTSITLTVRRTKPKKRKKSPEKG
RAAPKTKKIKNSPSEAQNLDENTTEGWENRIRL
WTDQYEEAFTNQYSADVQNALEQHLHSSKEFVG
KPTILDTINKTELACNNTVIGSQMQLQLGRVTRV
QKHRKILRAARDLALDTLIIEYRGKVMLRQQFE
VNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGN
DARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAI
TKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCP
IQKRNPNATELPLLPPPPSLPTIGAETRRRKAR
RKELEMEQQNEASEENNDQQSQEVPEKVTVSSDH
EEVDNPEEKPEEEKEEVIDDQENLAHSRRTRED
RKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEI
TTTTSETPVGEETKTEAPESEVSNSVSNVTIPST
PQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSR
PRPKSRISRYRTSSAQRLKRQKQANAQQAELSQ
AALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDP
TVVSITGSHVNRAASKYPKTKKYLVTEWLNDKA
EKQECPVECPLRITTDPTVLATTLNMLPGLIHS
PLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSS
CKKRWIKQALEEGMTQTSSVPQETRTQHLYQSN
ENSSSSSICKDNADLLSPLKKWKSRYLMEQNVT
KLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEE
ECRNGYSLMFSPVTSLTTASRCNTPLQFELCHR
KDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLA
PHPSLGPTSETGFPSRSGDGHQTLVRNSDQAFRT
EFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPL
HLDGGYCSPAEGFSSRYEHGLMKDLSRGSLSPG
GERACEGVPSAPQNPPQRKKVSLLEYRKRKQEAK
ENSAGGGGDSAQSKSKSAGAGQGSSNSVSDTGA
HGVQGSSARTPSSPHKKFSPSHSSMSHLEAVSP
SDSRGTSSSHCRPQENISSRWMVPTSVERLREGG
SIPKVLRSSVRVAQKGEPSPTWESNITEKDSDP
ADGEGPETLSSALSKGATVYSPSRYSYQLLQCD
SPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTAL
RPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLA
PFTGTPGYFSSQPHSGNSTGSNLPRRSCPSSAA
SPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNSR
SSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQ
HYPHRGSGGVHQYRLQPLQGSGVKTQTGLS*GF
WIWANRTE*AHSCFLPAASGT*AEHIAEERGVQG
ARGLGLVDKKQDLWSQLASGLGESCKSCLKQRL
*RSFSLLSRVHC*QANGVSVSNGSKCNELC*SL
RLPSLPVARSHLCSEDIFLNLKKKKKKVFKGKKV
KRANLKAPSHLSTVRVLCT*EKR*VCKCSS*DN
HSKSRYLANVCPPRILFIFVLRSPRNRQG**SL
EPAPTGGCLAL*RKAHGQLLIIREQII*VDCLSL
QLLPSYSPFPSYFTAQ*PMK*VDKKRRNET*YR
PIALLLTSFWQ*ISLGRIPSGLGMLRILFFLLP
INQELMIP*AGPPP*LGSMHL*LQGKSGKIGLWS
GTDRTVIVCGPAPHFSGGCLCESGPSERVTKPP
TPLTLFWMRDESRPASPHQCIVPVVHPWRSPGA
SPGGVHNLFKFHMVASLFLSLVYCNIWRVFIYLI
LYSVITMVGVVNI*QV*SLVLQWTFFSFGQDNT
VSFPPSFPLICFPFFPSLLHPLLFYPVLQLSYA
QSSLFVCDCYKISLFKIEIRCLLK*GEIFFFFFF
LNAETSAEYFSFCCFPHKPISLGEHWEWKSCCL
GCWFLCILYKTYVNVSPFGLGFAFSPWLFNQGE
RPAGRRPSPCLARAETPATLCGQGAVKTRPLGGV
GAGGWGELLEGKKYHFFLKWSVYTLL*HLNFHK
RCNNFDNKILNHNNHKVE
Sequence XM_931376
GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC
CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT
AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG
TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT
ACTCAGATATGGCTGCTGGATCAGAAAAGGAAGTGGAAGCCCCCTACCTTTCAAGACGAAGTGGCACTACACCAGGATGTGAAAGTCCAGCGAAAGAGAC
CCAAGGGGCCTAGGGGGCAGCACACCCCCAGAAGCCAAGTCTATTCCAGGCAGTACCAGGGATTAGGGTCTGGGCTGGAAAAATCCTGGTGTTTTGAATA
TGTTCAGGTCCAGTTCAGACTCTTGATCCCACAGCCACTTCTTGAGTGAGCCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATT
CCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGT
AGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGAC
AAGTGCAGGGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATG
AGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAA
GAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACGAAGAAAATCAAGGCATTTCGAGAGGGATCCCGGAAGTCCTTGCGGATGAAGAATTCTCCCTCTGAA
GCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACCAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAG
ATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAA
TAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTG
GACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCT
ACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCG
ACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGT
AACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTACCAC
CTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAA
TAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAA
GAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAGAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAA
GAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGA
AGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGG
GATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCC
AAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGA
AGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCT
AAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGG
ATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTACATTCGCTTTGGCTCACC
CTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACT
CAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTAGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGT
TGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTC
AGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCT
CTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGGATTTGGCAAAAGTAGGATACCTTGACTCCAACACTA
ACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTCCCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAG
AAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAACTTGATGTATGCCTACTCCCCTTTGAATGCTATGCCT
CGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATGGGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCA
GATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGCCTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACC
ACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCTGCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGC
AAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGCAGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACA
AAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAGAGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAA
TATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCCAAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAG
GGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAGAAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAG
GAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCC
CTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTC
TCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTG
GAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGT
TTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCT
GGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCC
AGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCC
AGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCA
CAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAA
ATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGA
CATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGG
GTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATAC
TGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCA
TGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCT
CAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAG
GAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATT
GGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTC
TCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTT
CTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAG
CTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAG
GTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCC
CCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCTCTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAA
AATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTC
CCCCACAAACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCT
CTCCATTTGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGAC
CCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGGGGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCAC
TTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATA
AAGTTGAGAA
- refseq_SETD5.F2 (forward primer)
- refseq_SETD5.R2 (reverse primer)
- Single exon skipping
Frame 0
AAAARLRSETHAAPVPPVRQHSSAGPPLSLALPPLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA
*LESCRLPGVPCAAARAQAPAAPGTRSSELLAD
NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV
VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL
LRYGCWIRKGSGSPLPFKTKWHYTRM*KSSERD
PRGLGGSTPPEAKSIPGSTRD*GLGWKNPGVLN
MFRSSSDS*SHSHFLSEP*ICGG*SSS**EERVF
HS*LWDHSEAWVSRTALCYDHPSF*PEWPAVAC
RGTLWRQPEL*RRNCTYLVSLWSFSGWLPSQL*
QVQGNEQGEGY*TSSAEAGQHIRWG*QCNRKLG*
GAFSFHCVVYSNTAHTYKHHLNC*KNQTQEAEK
ESRKGSCSTKDEENQGISRGIPEVLADEEFSL*
STEFR*EYN*GLGKSDKTMD*PV*RSFH*SVQCR
CTERA*TTPTF*QGICGQTYYFRHY**D*IGL*
*HSYWFPNAVTAGKSHSCSKAPEDPEGCKRFGF
GHSYNRVSWESHVTTAI*GQWAFLQKTIPLCALL
LKIQWCRDVCGCPYFR**CSVHQKIMYTKCRGA
THDCRWDDSPVHLCCVCHHQGC*GHHSI*L*V*
*L*L*SGLCLSQGKPELSYTKKES*CYRTATPTT
SSKPTHHWSRD*T*KSTTERARDGAAE*GFRGE
**PAITRSSRKSNCIQ*S*GSRQSRRKTRRRER
RGYR*PGEPSS*QEDQGR*KGRSHHACF*KLREK
KEAAGSALGTEQL*CRDYYNHLRDSCW*RDKN*
SP*I*S*QLCFKCYHPKHPTECWCEYPEVFPSR
GYCCRKTSPQATSSKAF*APAEESNFSVQDQFSP
KTKASEAGQCTAGRIVTSCLGRGRK*QFSNSY*
SWKSRQFRRKQAINRV*PNCGVNYWIPCQPCCI
*IPQNQKVSSYRMVE*QSREARVPC*VPFTYHNG
SNCTGNDPKHVTRSYPFPVNLHHPQTLHSLWLT
LYP*ETSKAPSA*WHIQLL*EALDKTSLRRRDD
SNIICTPRD*NSAPIPKQ*E**LF*YLQRQCRLV
EPIKEMEVSLSDGAECHQVTSASVSSHTTPSQF
RLKESPAGHTWLISPRRRGVSKWIQPHVFTSHI
SYYC*SLQHSSTV*ALSPKRPGFGKSRIP*LQH*
QLC**TFPTQLRSF*PGSSSLPRTHF*DWFPKQ
KWRWTSDPREKLRPGISDRVQLDVCLLPFECYA
SSRWTVSRISSSGG*EAFTFGWGILFPCRRIFQQ
I*TWLNERPLSWILVTWW*KGL*RSPICPPEPT
TEEKSIPAGVPKTETRS*GKFCWWGR*LCTEQK
QVCRSWARQQ*LRFRHWCPWCAGILSPNSIFPSQ
KILPISFLYVPFGGGKPIRFQRHFFISLQTSRE
YQQ*VDGSHISRTTPRRREHPQGPPKQREGGPK
GRALSHMGE*HHRERLRPCRWRRPRDIKLSTL*R
SNSLQPFQIQLPAPAV**SSDRITKPPSAEFLP
LQRTSYTVSRIQLSNYCTETWKPPLSRFFRIIP
LFHVLFQPRPPCVHRLVGPIYGDTRVF*QPATFW
KQHWQQSSKEELPF*CC*PYPAGTLRLANLRFS
FSVQHRNSEFHLLSSEL*VVIAIRLTDYQSAQC
WAVSCLPGLQGICGFQFTALPTPWEWGCAPVPTP
ATARVRSQDSDGTFLGLLDLGKQN*MSP*LLPS
SCLWNLGRAYC*GTGGTRCQRIGSGGQETRLVV
TIGLWPWRKL*ILSEAETIKKFLPAVKGTLLTSK
WCFG**RF*VQ*VVLKPPSPILACSP*SLVQ*G
HLFKFKKKKKKSFQRKKS*KSQSQSPKPSEYC*
GFMHLRKKVGM*MFILRQPFQKQVSGQCVSTKNT
VYLCLKITKK*ARIVKLGTCTNWRVPGSLKKSS
WSALDYSGADYLSRLSEPPTVTILLPLPKLFHS
SVTHEVSRQEKEE*DMI*ANCIATYQLLAINFIR
KDTEWFGNASNFIFSTPN*SGVDDPMSRTASMI
GEHALVTAG*EWEDRFVEWHRQDCDCVWACPTF
LWGMLM*EWAQ*KSYQATHTPNTVLDER*EQTGF
SPSVHCACCTPLEEPWSQPRWGTQSF*IPYGCQ
LISFTCLL*YLACFYLSNFVFSYNHGRGSEYMT
GVIPGAAVDLLFFWTR*YCEFPSFLPSNLFSFFP
QPLASPSFLPCPTTIICTVFSLCV*LLQNFTFQ
NRNQVFAQMRGDFFFFFFFKC*DLSRVLFFLLF
PPQTHQSGRALGVEIMLPGMLVSLYII*NVCKCL
SIWAGVCILPLAI*PRGEASGQAALTLPGTCRD
PSHSVWAGCCQDQTSWGGRGGGVGGTLGREEVS
LLSQVECLHLAVTFELSQEM**F***NS*P**S*
S*E
Frame 1
RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCPPSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG
PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI
IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW
SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS
YSDMAAGSEKEVEAPYLSRRSGTTPGCESPAKET
QGA*GAAHPQKPSLFQAVPGIRVWAGKILVF*I
CSGPVQTLDPTATS*VSPESVEASPAVNEKSVY
STHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPV
EERCGDSPNSEGETVPTWCPCGLSQDGFLLNCD
KCRGMSRGKVIRLHRRKQDNISGGDSSATESWD
EELSPSTVLYTATQHTPTSITLTVRRTKPKKRKK
SPEKGRAAPKTKKIKAFREGSRKSLRMKNSPSE
AQNLDENTTEGWENRIRLWTDQYEEAFTNQYSA
DVQNALEQHLHSSKEFVGKPTILDTINKTELACN
NTVIGSQMQLQLGRVTRVQKHRKILRAARDLAL
DTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLF
YSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVR
HMIADGMIHLCIYAVSAITKDAEVTIAFDYEYS
NCNYKVDCACHKGNRNCPIQKRNPNATELPLLP
PPPSLPTIGAETRRRKARRKELEMEQQNEASEEN
NDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKE
EVIDDQENLAHSRRTREDRKVEAIMHAFENLEK
RKKRRDQPLEQSNSDVEITTTTSETPVGEETKTE
APESEVSNSVSNVTIPSTPQSVGVNTRRSSQAG
DIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSA
QRLKRQKQANAQQAELSQAALEEGGSNSLVTPTE
AGSLDSSGENRPLTGSDPTVVSITGSHVNRAAS
KYPKTKKYLVTEWLNDKAEKQECPVECPLRITT
DPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSP
FIPERRRRPLLPDGTFSSCKKRWIKQALEEGMT
QTSSVPQETRTQHLYQSNENSSSSSICKDNADL
LSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNS
GSKSPQLATPGSSHPGEEECRNGYSLMFSPVTS
LTTASRCNTPLQFELCHRKDLDLAKVGYLDSNT
NSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSR
SGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMP
RADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSS
RYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPP
QRKKVSLLEYRKRKQEAKENSAGGGGDSAQSKS
KSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPH
KKFSPSHSSMSHLEAVSPSDSRGTSSSHCRPQEN
ISSRWMVPTSVERLREGGSIPKVLRSSVRVAQK
GEPSPTWESNITEKDSDPADGEGPETLSSALSK
GATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSP
FRGHPTQSPGYSYRTTALRPGNPPSHGSSESSL
SSTSYSSPAHPVSTDSLAPFTGTPGYFSSQPHS
GNSTGSNLPRRSCPSSAASPTLQGPSDSPTSDSV
SQSSTGTLSSTSFPQNSRSSLPSDLRTISLPSA
GQSAVYQASRVSAVSNSQHYPHRGSGGVHQYRL
QPLQGSGVKTQTGLS*GFWIWANRTE*AHSCFLP
AASGT*AEHIAEERGVQGARGLGLVDKKQDLWS
QLASGLGESCKSCLKQRL*RSFSLLSRVHC*QA
NGVSVSNGSKCNELC*SLRLPSLPVARSHLCSED
IFLNLKKKKKKVFKGKKVKRANLKAPSHLSTVR
VLCT*EKR*VCKCSS*DNHSKSRYLANVCPPRI
LFIFVLRSPRNRQG**SLEPAPTGGCLAL*RKAH
GQLLIIREQII*VDCLSLQLLPSYSPFPSYFTA
Q*PMK*VDKKRRNET*YRPIALLLTSFWQ*ISL
GRIPSGLGMLRILFFLLPINQELMIP*AGPPP*L
GSMHL*LQGKSGKIGLWSGTDRTVIVCGPAPHF
SGGCLCESGPSERVTKPPTPLTLFWMRDESRPA
SPHQCIVPVVHPWRSPGASPGGVHNLFKFHMVAS
LFLSLVYCNIWRVFIYLILYSVITMVGVVNI*Q
V*SLVLQWTFFSFGQDNTVSFPPSFPLICFPFF
PSLLHPLLFYPVLQLSYAQSSLFVCDCYKISLFK
IEIRCLLK*GEIFFFFFFLNAETSAEYFSFCCF
PHKPISLGEHWEWKSCCLGCWFLCILYKTYVNV
SPFGLGFAFSPWLFNQGERPAGRRPSPCLARAET
PATLCGQGAVKTRPLGGVGAGGWGELLEGKKYH
FFLKWSVYTLL*HLNFHKRCNNFDNKILNHNNH
KVE
Frame 2
GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAPPPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG
LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR
*FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG
QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP
TQIWLLDQKRKWKPPTFQDEVALHQDVKVQRKR
PKGPRGQHTPRSQVYSRQYQGLGSGLEKSWCFEY
VQVQFRLLIPQPLLE*ALNLWRLVQQLMRRACI
PLIIMGPLRGMGVEDCLMLRSSLVLT*MACRRL
*RNAVETARTLKEKLYLPGVLVVFLRMASFSTVT
SAGE*AGGRLLDFIGGSRTTYQVGIAVQQKAGM
RSFLLPLCCIQQHSTHLQASP*LLEEPNPRSGK
RVQKRVVQHQRRRKSRHFERDPGSPCG*RILPLK
HRI*MRIQLRAGKIG*DYGLTSMKKLSLISTVQ
MYRTRLNNTYILARNLWANLLF*TLLIRLNWPV
ITQLLVPKCSYSWEESLVFKSTGRS*GLQEIWLW
TLL**SIVGKSCYDSNLRSMGISSKNHTPLCSS
TQNSMV*RCVWMPVLSVMMLGSSEDHVHQMQRC
DT*LQMG*FTCASMLCLPSPRMLRSP*HLIMSIV
TVIIKWTVPVTRETGIVLYKKGILMLQNCHSYH
LLQAYPPLEQRLDVEKHDGKS*RWSSRMRLQRR
IMTSNHKKFQKK*LYPVIMRK*TIQKKNQKKRKK
RL*MTRRT*LIAGGPGKIER*KPSCMLLKT*RK
ERSGGISPWNRATLM*RLLQPPQRLLLVKRQKL
KPLNLKLATLFQMLPSQAPHRVLV*IPGGLPKQG
ILLQKN*SPSHLQQSLLGPGRRVEFLGTGPVQP
KD*SVRSRPMHSRQNCHKLPWKREEVTV**LLL
KLEV*TVQEKTGH*QGLTQLWCQLLDPMSTVLHL
NTPKPKSI*LQNG*MTKQRSKSALLSALYVSQR
IQLYWQRP*TCYQVLSIPR*FAPPPNTTFALAH
PLSLRDVEGPFCLMAHSAPVRSAG*NKP*KKG*L
KHHLYPKRLELSTYTKAMRIVALLVSAKTMQTC
*AH*RNGSLAI*WSRMSPSYFGLCLQSHHPLPI
QAQRVPSWPHLAHLTQEKRSVEMDTASCFHQSHL
LLLLVAATLLYSLSFVTEKTWIWQK*DTLTPTL
TAVLIDLPYSTQVILTWLLIPPSDPLLRLVSQA
EVEMDIRPS*ETQTRHFGQSST*CMPTPL*MLCL
EQMDCIEDLL*WGIGSLYIWMGDIVPLQKDFPA
DMNMA**KTSLVDPCHLVVKGPVKESHLPPRTH
HRGKKYPCWSTENGNKKLRKILLVGEVTLHRAKA
SLQELGKAAVTPFPTLVPMVCRDPQPELHLPLT
KNSPHLIPLCPIWRR*AHQIPEALLHLTADLKR
ISAVGGWFPHQ*NDSEKEGASPRSSEAA*GWPKR
ESPLPHGRVTSQRKTQTLQMEKAQRH*AQHSLK
EQQFTALPDTATSSCSVIVLGQNHKASFSRVPP
PSEDILHSLQDTVIELLH*DLETPPLTVLQNHPS
LPRPIPAPPTLCPQTRWPHLRGHQGILAASHIL
ETALAAIFQGGAALLVLLALPCRDPQTRQPQIQ
FLSPAQEL*VPPPFLRTLGRHCHQTYGLSVCPVL
GSQLSTRPPGYLRFPIHSTTHTVGVGVCTSTDS
SHCKGQESRLRRDFPRASGFGQTELNEPIAASF
QLPLEPRPSILLRNGGYKVPEDWVWWTRNKTCGH
NWPLALEKAVNLV*SRDYKEVSPCCQGYIVDKQ
MVFRLVTVLSAMSCVEASVSHPCL*PVVTCAVR
TSF*I*KKKKKKFSKEKKLKEPISKPQAI*VLLG
FYALKKKGRYVNVHPKTTIPKAGIWPMCVHQEY
CLSLS*DHQEIGKDSKAWNLHQLEGAWLFEEKL
MVSS*LFGSRLFE*IV*ASNCYHPTPPSQAISQL
SNP*SK*TRKGGMRHDIGQLHCYLPAFGNKFH*
EGYRVVWECFEFYFFYSQLIRS**SHEQDRLHD
WGACTCDCRVRVGR*VCGVAPTGL*LCVGLPHIS
LGDAYVRVGPVKELPSHPHP*HCSG*EMRADRL
LPISALCLLYTPGGALEPAQVGYTIFLNSIWLP
AYFFHLFTVISGVFLFI*FCIQL*PW*G**IYDR
CNPWCCSGPSFLLDKIIL*VSLLPSL*FVFLFS
PASCIPFFSTLSYNYHMHSLLSLCVTVTKFHFS
KSKSGVCSNEGRFFFFFFF*MLRPQQSTFLFVVS
PTNPSVWESIGSGNHVAWDAGFFVYYIKRM*MS
LHLGWGLHSPLGYLTKGRGQRAGGPHPAWHVQR
PQPLCVGRVLSRPDLLGG*GRGGGGNSWKGRSIT
SFSSGVFTPCCNI*TFTRDVIILIIKFLTIIII
KLR
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