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Sequences

Sequence XM_931455

GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCC CCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGAACATATCCTCCCCTGAGAGTT CCCCTGCGCATAGGCCCGAGTCCCTGTCACCCGAGCTTTGTCACCGAAAAGACCTGGATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTG TGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTCCCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGA GATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAACTTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAG ATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATGGGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGA ACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGCCTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGG AAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCTGCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTG CAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGCAGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATT CTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAGAGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGC AGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCCAAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGC CCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAGAAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAAC AGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGA GGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCA CGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAG CACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAG TCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGT CAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACT GCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCC TCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGG CCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGT TTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTT TTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTAT GCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTAT CTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAG CTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAAC CCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGAT ACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGC ATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGG GATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCA TCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTT CTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAAT CCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCT CTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCTCTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAA ATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACA AACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATT TGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGACCCCAGCC ACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGGGGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTC TCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGA GAA

refseq_SETD5.F5 (forward primer)
refseq_SETD5.R5 (reverse primer)
Single exon skipping

Frame 0

AAAARLRSETHAAPVPPVRQHSSAGPPLSLALP PLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA *LESCRLPGVPCAAARAQAPAAPGTRSSELLAD NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E** LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS KWIQPHVFTSHISYYC*SLQHSSTV*EHILP*EF PCA*ARVPVTRALSPKRPGFGKSRIP*LQH*QL C**TFPTQLRSF*PGSSSLPRTHF*DWFPKQKW RWTSDPREKLRPGISDRVQLDVCLLPFECYASSR WTVSRISSSGG*EAFTFGWGILFPCRRIFQQI* TWLNERPLSWILVTWW*KGL*RSPICPPEPTTE EKSIPAGVPKTETRS*GKFCWWGR*LCTEQKQVC RSWARQQ*LRFRHWCPWCAGILSPNSIFPSQKI LPISFLYVPFGGGKPIRFQRHFFISLQTSREYQ Q*VDGSHISRTTPRRREHPQGPPKQREGGPKGRA LSHMGE*HHRERLRPCRWRRPRDIKLSTL*RSN SLQPFQIQLPAPAV**SSDRITKPPSAEFLPLQ RTSYTVSRIQLSNYCTETWKPPLSRFFRIIPLFH VLFQPRPPCVHRLVGPIYGDTRVF*QPATFWKQ HWQQSSKEELPF*CC*PYPAGTLRLANLRFSFS VQHRNSEFHLLSSEL*VVIAIRLTDYQSAQCWAV SCLPGLQGICGFQFTALPTPWEWGCAPVPTPAT ARVRSQDSDGTFLGLLDLGKQN*MSP*LLPSSC LWNLGRAYC*GTGGTRCQRIGSGGQETRLVVTIG LWPWRKL*ILSEAETIKKFLPAVKGTLLTSKWC FG**RF*VQ*VVLKPPSPILACSP*SLVQ*GHL FKFKKKKKKSFQRKKS*KSQSQSPKPSEYC*GFM HLRKKVGM*MFILRQPFQKQVSGQCVSTKNTVY LCLKITKK*ARIVKLGTCTNWRVPGSLKKSSWS ALDYSGADYLSRLSEPPTVTILLPLPKLFHSSVT HEVSRQEKEE*DMI*ANCIATYQLLAINFIRKD TEWFGNASNFIFSTPN*SGVDDPMSRTASMIGE HALVTAG*EWEDRFVEWHRQDCDCVWACPTFLWG MLM*EWAQ*KSYQATHTPNTVLDER*EQTGFSP SVHCACCTPLEEPWSQPRWGTQSF*IPYGCQLI SFTCLL*YLACFYLSNFVFSYNHGRGSEYMTGVI PGAAVDLLFFWTR*YCEFPSFLPSNLFSFFPQP LASPSFLPCPTTIICTVFSLCV*LLQNFTFQNR NQVFAQMRGDFFFFFFFKC*DLSRVLFFLLFPPQ THQSGRALGVEIMLPGMLVSLYII*NVCKCLSI WAGVCILPLAI*PRGEASGQAALTLPGTCRDPS HSVWAGCCQDQTSWGGRGGGVGGTLGREEVSLLS QVECLHLAVTFELSQEM**F***NS*P**S*S* E

Frame 1

RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCP PSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR NGYSLMFSPVTSLTTASRCNTPLQFENISSPES SPAHRPESLSPELCHRKDLDLAKVGYLDSNTNSC ADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSG DGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRA DGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYE HGLMKDLSRGSLSPGGERACEGVPSAPQNPPQR KKVSLLEYRKRKQEAKENSAGGGGDSAQSKSKS AGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKF SPSHSSMSHLEAVSPSDSRGTSSSHCRPQENIS SRWMVPTSVERLREGGSIPKVLRSSVRVAQKGE PSPTWESNITEKDSDPADGEGPETLSSALSKGAT VYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFR GHPTQSPGYSYRTTALRPGNPPSHGSSESSLSS TSYSSPAHPVSTDSLAPFTGTPGYFSSQPHSGNS TGSNLPRRSCPSSAASPTLQGPSDSPTSDSVSQ SSTGTLSSTSFPQNSRSSLPSDLRTISLPSAGQ SAVYQASRVSAVSNSQHYPHRGSGGVHQYRLQPL QGSGVKTQTGLS*GFWIWANRTE*AHSCFLPAA SGT*AEHIAEERGVQGARGLGLVDKKQDLWSQL ASGLGESCKSCLKQRL*RSFSLLSRVHC*QANGV SVSNGSKCNELC*SLRLPSLPVARSHLCSEDIF LNLKKKKKKVFKGKKVKRANLKAPSHLSTVRVL CT*EKR*VCKCSS*DNHSKSRYLANVCPPRILFI FVLRSPRNRQG**SLEPAPTGGCLAL*RKAHGQ LLIIREQII*VDCLSLQLLPSYSPFPSYFTAQ* PMK*VDKKRRNET*YRPIALLLTSFWQ*ISLGRI PSGLGMLRILFFLLPINQELMIP*AGPPP*LGS MHL*LQGKSGKIGLWSGTDRTVIVCGPAPHFSG GCLCESGPSERVTKPPTPLTLFWMRDESRPASPH QCIVPVVHPWRSPGASPGGVHNLFKFHMVASLF LSLVYCNIWRVFIYLILYSVITMVGVVNI*QV* SLVLQWTFFSFGQDNTVSFPPSFPLICFPFFPSL LHPLLFYPVLQLSYAQSSLFVCDCYKISLFKIE IRCLLK*GEIFFFFFFLNAETSAEYFSFCCFPH KPISLGEHWEWKSCCLGCWFLCILYKTYVNVSPF GLGFAFSPWLFNQGERPAGRRPSPCLARAETPA TLCGQGAVKTRPLGGVGAGGWGELLEGKKYHFF LKWSVYTLL*HLNFHKRCNNFDNKILNHNNHKVE

Frame 2

GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAP PPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR *FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT SMKKLSLISTVQMYRTRLNNTYILARNLWANLL F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS *RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK* TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER* KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE MDTASCFHQSHLLLLLVAATLLYSLRTYPPLRV PLRIGPSPCHPSFVTEKTWIWQK*DTLTPTLTA VLIDLPYSTQVILTWLLIPPSDPLLRLVSQAEVE MDIRPS*ETQTRHFGQSST*CMPTPL*MLCLEQ MDCIEDLL*WGIGSLYIWMGDIVPLQKDFPADM NMA**KTSLVDPCHLVVKGPVKESHLPPRTHHRG KKYPCWSTENGNKKLRKILLVGEVTLHRAKASL QELGKAAVTPFPTLVPMVCRDPQPELHLPLTKN SPHLIPLCPIWRR*AHQIPEALLHLTADLKRISA VGGWFPHQ*NDSEKEGASPRSSEAA*GWPKRES PLPHGRVTSQRKTQTLQMEKAQRH*AQHSLKEQ QFTALPDTATSSCSVIVLGQNHKASFSRVPPPSE DILHSLQDTVIELLH*DLETPPLTVLQNHPSLP RPIPAPPTLCPQTRWPHLRGHQGILAASHILET ALAAIFQGGAALLVLLALPCRDPQTRQPQIQFLS PAQEL*VPPPFLRTLGRHCHQTYGLSVCPVLGS QLSTRPPGYLRFPIHSTTHTVGVGVCTSTDSSH CKGQESRLRRDFPRASGFGQTELNEPIAASFQLP LEPRPSILLRNGGYKVPEDWVWWTRNKTCGHNW PLALEKAVNLV*SRDYKEVSPCCQGYIVDKQMV FRLVTVLSAMSCVEASVSHPCL*PVVTCAVRTSF *I*KKKKKKFSKEKKLKEPISKPQAI*VLLGFY ALKKKGRYVNVHPKTTIPKAGIWPMCVHQEYCL SLS*DHQEIGKDSKAWNLHQLEGAWLFEEKLMVS S*LFGSRLFE*IV*ASNCYHPTPPSQAISQLSN P*SK*TRKGGMRHDIGQLHCYLPAFGNKFH*EG YRVVWECFEFYFFYSQLIRS**SHEQDRLHDWGA CTCDCRVRVGR*VCGVAPTGL*LCVGLPHISLG DAYVRVGPVKELPSHPHP*HCSG*EMRADRLLP ISALCLLYTPGGALEPAQVGYTIFLNSIWLPAYF FHLFTVISGVFLFI*FCIQL*PW*G**IYDRCN PWCCSGPSFLLDKIIL*VSLLPSL*FVFLFSPA SCIPFFSTLSYNYHMHSLLSLCVTVTKFHFSKSK SGVCSNEGRFFFFFFF*MLRPQQSTFLFVVSPT NPSVWESIGSGNHVAWDAGFFVYYIKRM*MSLH LGWGLHSPLGYLTKGRGQRAGGPHPAWHVQRPQP LCVGRVLSRPDLLGG*GRGGGGNSWKGRSITSF SSGVFTPCCNI*TFTRDVIILIIKFLTIIIIKL R

Sequence XM_926615

GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCC CCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAG AAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGAC AGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGA AACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGG GGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCT GCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTG CCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCAC ACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGC AAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGA TTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTT TCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATC CTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCC AATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAA GCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACC AACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTA CCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCAT TGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGA GTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGAC AGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAA CACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGG GGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCA GTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCC CTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCT CTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCT GAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACAAACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGT TTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATTTGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGG CAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGACCCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGG GGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATA ATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGAGAA

refseq_SETD5.F5 (forward primer)
refseq_SETD5.R5 (reverse primer)
Single exon skipping

Frame 0

AAAARLRSETHAAPVPPVRQHSSAGPPLSLALP PLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA *LESCRLPGVPCAAARAQAPAAPGTRSSELLAD NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E** LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP QGPPKQREGGPKGRALSHMGE*HHRERLRPCRWR RPRDIKLSTL*RSNSLQPFQIQLPAPAV**SSD RITKPPSAEFLPLQRTSYTVSRIQLSNYCTETW KPPLSRFFRIIPLFHVLFQPRPPCVHRLVGPIYG DTRVF*QPATFWKQHWQQSSKEELPF*CC*PYP AGTLRLANLRFSFSVQHRNSEFHLLSSEL*VVI AIRLTDYQSAQCWAVSCLPGLQGICGFQFTALPT PWEWGCAPVPTPATARVRSQDSDGTFLGLLDLG KQN*MSP*LLPSSCLWNLGRAYC*GTGGTRCQR IGSGGQETRLVVTIGLWPWRKL*ILSEAETIKKF LPAVKGTLLTSKWCFG**RF*VQ*VVLKPPSPI LACSP*SLVQ*GHLFKFKKKKKKSFQRKKS*KS QSQSPKPSEYC*GFMHLRKKVGM*MFILRQPFQK QVSGQCVSTKNTVYLCLKITKK*ARIVKLGTCT NWRVPGSLKKSSWSALDYSGADYLSRLSEPPTV TILLPLPKLFHSSVTHEVSRQEKEE*DMI*ANCI ATYQLLAINFIRKDTEWFGNASNFIFSTPN*SG VDDPMSRTASMIGEHALVTAG*EWEDRFVEWHR QDCDCVWACPTFLWGMLM*EWAQ*KSYQATHTPN TVLDER*EQTGFSPSVHCACCTPLEEPWSQPRW GTQSF*IPYGCQLISFTCLL*YLACFYLSNFVF SYNHGRGSEYMTGVIPGAAVDLLFFWTR*YCEFP SFLPSNLFSFFPQPLASPSFLPCPTTIICTVFS LCV*LLQNFTFQNRNQVFAQMRGDFFFFFFFKC *DLSRVLFFLLFPPQTHQSGRALGVEIMLPGMLV SLYII*NVCKCLSIWAGVCILPLAI*PRGEASG QAALTLPGTCRDPSHSVWAGCCQDQTSWGGRGG GVGGTLGREEVSLLSQVECLHLAVTFELSQEM** F***NS*P**S*S*E

Frame 1

RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCP PSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR GTSSSHCRPQENISSRWMVPTSVERLREGGSIP KVLRSSVRVAQKGEPSPTWESNITEKDSDPADG EGPETLSSALSKGATVYSPSRYSYQLLQCDSPRT ESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPG NPPSHGSSESSLSSTSYSSPAHPVSTDSLAPFT GTPGYFSSQPHSGNSTGSNLPRRSCPSSAASPTL QGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSL PSDLRTISLPSAGQSAVYQASRVSAVSNSQHYP HRGSGGVHQYRLQPLQGSGVKTQTGLS*GFWIWA NRTE*AHSCFLPAASGT*AEHIAEERGVQGARG LGLVDKKQDLWSQLASGLGESCKSCLKQRL*RS FSLLSRVHC*QANGVSVSNGSKCNELC*SLRLPS LPVARSHLCSEDIFLNLKKKKKKVFKGKKVKRA NLKAPSHLSTVRVLCT*EKR*VCKCSS*DNHSK SRYLANVCPPRILFIFVLRSPRNRQG**SLEPAP TGGCLAL*RKAHGQLLIIREQII*VDCLSLQLL PSYSPFPSYFTAQ*PMK*VDKKRRNET*YRPIA LLLTSFWQ*ISLGRIPSGLGMLRILFFLLPINQE LMIP*AGPPP*LGSMHL*LQGKSGKIGLWSGTD RTVIVCGPAPHFSGGCLCESGPSERVTKPPTPL TLFWMRDESRPASPHQCIVPVVHPWRSPGASPGG VHNLFKFHMVASLFLSLVYCNIWRVFIYLILYS VITMVGVVNI*QV*SLVLQWTFFSFGQDNTVSF PPSFPLICFPFFPSLLHPLLFYPVLQLSYAQSSL FVCDCYKISLFKIEIRCLLK*GEIFFFFFFLNA ETSAEYFSFCCFPHKPISLGEHWEWKSCCLGCW FLCILYKTYVNVSPFGLGFAFSPWLFNQGERPAG RRPSPCLARAETPATLCGQGAVKTRPLGGVGAG GWGELLEGKKYHFFLKWSVYTLL*HLNFHKRCN NFDNKILNHNNHKVE

Frame 2

GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAP PPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR *FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT SMKKLSLISTVQMYRTRLNNTYILARNLWANLL F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS *RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK* TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER* KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST *CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP RSSEAA*GWPKRESPLPHGRVTSQRKTQTLQME KAQRH*AQHSLKEQQFTALPDTATSSCSVIVLG QNHKASFSRVPPPSEDILHSLQDTVIELLH*DLE TPPLTVLQNHPSLPRPIPAPPTLCPQTRWPHLR GHQGILAASHILETALAAIFQGGAALLVLLALP CRDPQTRQPQIQFLSPAQEL*VPPPFLRTLGRHC HQTYGLSVCPVLGSQLSTRPPGYLRFPIHSTTH TVGVGVCTSTDSSHCKGQESRLRRDFPRASGFG QTELNEPIAASFQLPLEPRPSILLRNGGYKVPED WVWWTRNKTCGHNWPLALEKAVNLV*SRDYKEV SPCCQGYIVDKQMVFRLVTVLSAMSCVEASVSH PCL*PVVTCAVRTSF*I*KKKKKKFSKEKKLKEP ISKPQAI*VLLGFYALKKKGRYVNVHPKTTIPK AGIWPMCVHQEYCLSLS*DHQEIGKDSKAWNLH QLEGAWLFEEKLMVSS*LFGSRLFE*IV*ASNCY HPTPPSQAISQLSNP*SK*TRKGGMRHDIGQLH CYLPAFGNKFH*EGYRVVWECFEFYFFYSQLIR S**SHEQDRLHDWGACTCDCRVRVGR*VCGVAPT GL*LCVGLPHISLGDAYVRVGPVKELPSHPHP* HCSG*EMRADRLLPISALCLLYTPGGALEPAQV GYTIFLNSIWLPAYFFHLFTVISGVFLFI*FCIQ L*PW*G**IYDRCNPWCCSGPSFLLDKIIL*VS LLPSL*FVFLFSPASCIPFFSTLSYNYHMHSLL SLCVTVTKFHFSKSKSGVCSNEGRFFFFFFF*ML RPQQSTFLFVVSPTNPSVWESIGSGNHVAWDAG FFVYYIKRM*MSLHLGWGLHSPLGYLTKGRGQR AGGPHPAWHVQRPQPLCVGRVLSRPDLLGG*GRG GGGNSWKGRSITSFSSGVFTPCCNI*TFTRDVI ILIIKFLTIIIIKLR

Sequence XM_931444

GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCC CCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGGTGAGCCCATGGCCT TCTGCTGCCACCACATTCAGGGACACATGAGCCGAGTCCTGTACAGTTCATGCCTAGTGCTGAGTTGAGGTGAGTCAGTTTCTGATGCAGTTGGGCTCCA CCGCATGCTAGGTTCCAGCCCACTTATGCTCATTTGGGCTACCACATTTGTAAGATCTAGCATTGCTTGCTCTCTGTCTGCTCTTTTTTCCCCAAGGAAT ACCTTTCTGTAACTCTCATCTCTCCAAAGTCCTGGAAATCTACCTCGATGAAGGATGAAGAGAAAGAAGACGGGAATCACATCAGGCATTTAGAACATAG CCCATAATTAACCACTCATTTTGCCCTTCTGGCATGCTGCACTCACCCAATTTGTCACAAAGAGAGCAGTACGGGTTGGTGATGGCACTGGTGATTTAAA TGAAAAATGGCTCTTTCTTACTTATTCTAAGAAGCCAAGTTGATTTTTTTTTATATATGTTACCTTCCAGACCCTGCAGATGGAGAAGGCCCAGAGACAT TAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGGTGAGATGAGAAATTGCTGGTCTCTAGCCATAGGAGTGTGT TCTGGGTCCCAAATTGTCCTGGTCATCCTTTGCCATTGAGATGCTGTCTTTGCATATAGTTTCAGCAGCCTTGGAAATAAGTCATCATCTGCTTGTCCTC AGGTAATAAATTATGCCAGAAGATGAATACGGTGATCAAAGACAGACATTTTACTGCCTTTGGTTTCCTAAAAAGAATACATGGTTAAAAGATGAAGAAA AAAGAATGTAGGGTATTATAAATGTTCACCAGCCATTTAAGGGACTTGTTCGCGTCCTTATTCGTTTCCTCCCAACTTTGTCTAGCTCCTGCAGTGTGAT AGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCAC TGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGC CCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCT AGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTA GGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACA GCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTC TGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAG GTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACT ATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTC CGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAG TTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAA CCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTG GAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCC TCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAG GCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCA ATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGA GTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACC CACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCC AGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAA TTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATAC TGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCT

refseq_SETD5.F5 (forward primer)
refseq_SETD5.R5 (reverse primer)
Single exon skipping

Frame 0

AAAARLRSETHAAPVPPVRQHSSAGPPLSLALP PLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA *LESCRLPGVPCAAARAQAPAAPGTRSSELLAD NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E** LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP QGPPKQREGGPKGRALSHMGE*HHRERLR*AHGL LLPPHSGTHEPSPVQFMPSAELR*VSF*CSWAP PHARFQPTYAHLGYHICKI*HCLLSVCSFFPKE YLSVTLISPKSWKSTSMKDEEKEDGNHIRHLEHS P*LTTHFALLACCTHPICHKESSTGW*WHW*FK *KMALSYLF*EAKLIFFYICYLPDPADGEGPET LSSALSKGATVYSPSRYSYQVR*EIAGL*P*ECV LGPKLSWSSFAIEMLSLHIVSAALEISHHLLVL R**IMPEDEYGDQRQTFYCLWFPKKNTWLKDEE KRM*GIINVHQPFKGLVRVLIRFLPTLSSSCSVI VLGQNHKASFSRVPPPSEDILHSLQDTVIELLH *DLETPPLTVLQNHPSLPRPIPAPPTLCPQTRW PHLRGHQGILAASHILETALAAIFQGGAALLVLL ALPCRDPQTRQPQIQFLSPAQEL*VPPPFLRTL GRHCHQTYGLSVCPVLGSQLSTRPPGYLRFPIH STTHTVGVGVCTSTDSSHCKGQESRLRRDFPRAS GFGQTELNEPIAASFQLPLEPRPSILLRNGGYK VPEDWVWWTRNKTCGHNWPLALEKAVNLV*SRD YKEVSPCCQGYIVDKQMVFRLVTVLSAMSCVEAS VSHPCL*PVVTCAVRTSF*I*KKKKKKFSKEKK LKEPISKPQAI*VLLGFYALKKKGRYVNVHPKT TIPKAGIWPMCVHQEYCLSLS*DHQEIGKDSKAW NLHQLEGAWLFEEKLMVSS*LFGSRLFE*IV*A SNCYHPTPPSQAISQLSNP*SK*TRKGGMRHDI GQLHCYLPAFGNKFH*EGYRVVWECFEFYFFYSQ LIRS**SHEQDRLHDWGACTCDCRVRVGR*VCG VAPTGL*LCVGLPHISLGDAYVRVGPVKELPSH PHP*HCSG*EMRADRLLPISALCLLYTPGGALEP AQVGYTIFLNSIWLPAYFFHLFTVISGVFLFI* FCIQL*PW*G**IYDRCNPWCCSGPSFLLDKII L*VSLLPSL*FVFLFSPASCIPFFST

Frame 1

RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCP PSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR GTSSSHCRPQENISSRWMVPTSVERLREGGSIP KVLRSSVRVAQKGEPSPTWESNITEKDSGEPMA FCCHHIQGHMSRVLYSSCLVLS*GESVSDAVGLH RMLGSSPLMLIWATTFVRSSIACSLSALFSPRN TFL*LSSLQSPGNLPR*RMKRKKTGITSGI*NI AHN*PLILPFWHAALTQFVTKRAVRVGDGTGDLN EKWLFLTYSKKPS*FFFIYVTFQTLQMEKAQRH *AQHSLKEQQFTALPDTATR*DEKLLVSSHRSV FWVPNCPGHPLPLRCCLCI*FQQPWK*VIICLSS GNKLCQKMNTVIKDRHFTAFGFLKRIHG*KMKK KECRVL*MFTSHLRDLFASLFVSSQLCLAPAV* *SSDRITKPPSAEFLPLQRTSYTVSRIQLSNYCT ETWKPPLSRFFRIIPLFHVLFQPRPPCVHRLVG PIYGDTRVF*QPATFWKQHWQQSSKEELPF*CC *PYPAGTLRLANLRFSFSVQHRNSEFHLLSSEL* VVIAIRLTDYQSAQCWAVSCLPGLQGICGFQFT ALPTPWEWGCAPVPTPATARVRSQDSDGTFLGL LDLGKQN*MSP*LLPSSCLWNLGRAYC*GTGGTR CQRIGSGGQETRLVVTIGLWPWRKL*ILSEAET IKKFLPAVKGTLLTSKWCFG**RF*VQ*VVLKP PSPILACSP*SLVQ*GHLFKFKKKKKKSFQRKKS *KSQSQSPKPSEYC*GFMHLRKKVGM*MFILRQ PFQKQVSGQCVSTKNTVYLCLKITKK*ARIVKL GTCTNWRVPGSLKKSSWSALDYSGADYLSRLSEP PTVTILLPLPKLFHSSVTHEVSRQEKEE*DMI* ANCIATYQLLAINFIRKDTEWFGNASNFIFSTP N*SGVDDPMSRTASMIGEHALVTAG*EWEDRFVE WHRQDCDCVWACPTFLWGMLM*EWAQ*KSYQAT HTPNTVLDER*EQTGFSPSVHCACCTPLEEPWS QPRWGTQSF*IPYGCQLISFTCLL*YLACFYLSN FVFSYNHGRGSEYMTGVIPGAAVDLLFFWTR*Y CEFPSFLPSNLFSFFPQPLASPSFLP

Frame 2

GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAP PPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR *FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT SMKKLSLISTVQMYRTRLNNTYILARNLWANLL F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS *RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK* TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER* KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST *CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP RSSEAA*GWPKRESPLPHGRVTSQRKTQVSPWP SAATTFRDT*AESCTVHA*C*VEVSQFLMQLGS TAC*VPAHLCSFGLPHL*DLALLALCLLFFPQGI PFCNSHLSKVLEIYLDEG*RERRRESHQAFRT* PIINHSFCPSGMLHSPNLSQREQYGLVMALVI* MKNGSFLLILRSQVDFFLYMLPSRPCRWRRPRDI KLSTL*RSNSLQPFQIQLPGEMRNCWSLAIGVC SGSQIVLVILCH*DAVFAYSFSSLGNKSSSACP QVINYARR*IR*SKTDILLPLVS*KEYMVKR*RK KNVGYYKCSPAI*GTCSRPYSFPPNFV*LLQCD SPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTA LRPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLA PFTGTPGYFSSQPHSGNSTGSNLPRRSCPSSAA SPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNS RSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQ HYPHRGSGGVHQYRLQPLQGSGVKTQTGLS*GF WIWANRTE*AHSCFLPAASGT*AEHIAEERGVQ GARGLGLVDKKQDLWSQLASGLGESCKSCLKQRL *RSFSLLSRVHC*QANGVSVSNGSKCNELC*SL RLPSLPVARSHLCSEDIFLNLKKKKKKVFKGKK VKRANLKAPSHLSTVRVLCT*EKR*VCKCSS*DN HSKSRYLANVCPPRILFIFVLRSPRNRQG**SL EPAPTGGCLAL*RKAHGQLLIIREQII*VDCLS LQLLPSYSPFPSYFTAQ*PMK*VDKKRRNET*YR PIALLLTSFWQ*ISLGRIPSGLGMLRILFFLLP INQELMIP*AGPPP*LGSMHL*LQGKSGKIGLW SGTDRTVIVCGPAPHFSGGCLCESGPSERVTKPP TPLTLFWMRDESRPASPHQCIVPVVHPWRSPGA SPGGVHNLFKFHMVASLFLSLVYCNIWRVFIYL ILYSVITMVGVVNI*QV*SLVLQWTFFSFGQDNT VSFPPSFPLICFPFFPSLLHPLLFYP

Sequence XM_931447

GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCC CCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT ACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCA GAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCG AACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGA AGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTT GTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCA CCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACC AGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTAT TTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCAC CGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGC ATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTT CATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAA GGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCT AGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTA GACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAG AAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCAC CTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGT GTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGA AGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGA AGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAG AGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTG CACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAG CGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTA GCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCG GCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGA AATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGG ATTTGGCAAAAGTAGGATACCTTGACTCCAACACTAACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTC CCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAGAAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAAC TTGATGTATGCCTACTCCCCTTTGAATGCTATGCCTCGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATG GGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCAGATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGC CTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACCACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCT GCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGCAAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGC AGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACAAAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAG AGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAATATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCC AAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAGGGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAG AAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAGGAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGGTGAGATGAGAAATTGCTGGTCTCTA GCCATAGGAGTGTGTTCTGGGTCCCAAATTGTCCTGGTCATCCTTTGCCATTGAGATGCTGTCTTTGCATATAGTTTCAGCAGCCTTGGAAATAAGTCAT CATCTGCTTGTCCTCAGGTAATAAATTATGCCAGAAGATGAATACGGTGATCAAAGACAGACATTTTACTGCCTTTGGTTTCCTAAAAAGAATACATGGT TAAAAGATGAAGAAAAAAGAATGTAGGGTATTATAAATGTTCACCAGCCATTTAAGGGACTTGTTCGCGTCCTTATTCGTTTCCTCCCAACTTTGTCTAG CTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCCCTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTT ATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTCTCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTC CACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTGGAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGC CCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGTTTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCT TTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCTGGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGC GGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCCAGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGA CTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGG AACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTG TCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAG TTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTT TCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATG TTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAA GGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAG TAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAA TGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTA TTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGA AGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAG AGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGG AGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTG TTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTT TGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCT

refseq_SETD5.F5 (forward primer)
refseq_SETD5.R5 (reverse primer)
Single exon skipping

Frame 0

AAAARLRSETHAAPVPPVRQHSSAGPPLSLALP PLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA *LESCRLPGVPCAAARAQAPAAPGTRSSELLAD NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL LRYGCWIRP*ICGG*SSS**EERVFHS*LWDHS EAWVSRTALCYDHPSF*PEWPAVACRGTLWRQP EL*RRNCTYLVSLWSFSGWLPSQL*QVQGNEQGE GY*TSSAEAGQHIRWG*QCNRKLG*GAFSFHCV VYSNTAHTYKHHLNC*KNQTQEAEKESRKGSCS TKDEENQEFSL*STEFR*EYN*GLGKSDKTMD*P V*RSFH*SVQCRCTERA*TTPTF*QGICGQTYY FRHY**D*IGL**HSYWFPNAVTAGKSHSCSKA PEDPEGCKRFGFGHSYNRVSWESHVTTAI*GQWA FLQKTIPLCALLLKIQWCRDVCGCPYFR**CSV HQKIMYTKCRGATHDCRWDDSPVHLCCVCHHQG C*GHHSI*L*V**L*L*SGLCLSQGKPELSYTKK ES*CYRTATPTTSSKPTHHWSRD*T*KSTTERA RDGAAE*GFRGE**PAITRSSRKSNCIQ*S*GS RQSRRKTRRRERRGYR*PGEPSS*QEDQGR*KGR SHHACF*KLREKKEAAGSALGTEQL*CRDYYNH LRDSCW*RDKN*SP*I*S*QLCFKCYHPKHPTE CWCEYPEVFPSRGYCCRKTSPQATSSKAF*APAE ESNFSVQDQFSPKTKASEAGQCTAGRIVTSCLG RGRK*QFSNSY*SWKSRQFRRKQAINRV*PNCG VNYWIPCQPCCI*IPQNQKVSSYRMVE*QSREAR VPC*VPFTYHNGSNCTGNDPKHVTRSYPFPVNL HHPQTLHSLWLTLYP*ETSKAPSA*WHIQLL*E ALDKTSLRRRDDSNIICTPRD*NSAPIPKQ*E** LF*YLQRQCRLVEPIKEMEVSLSDGAECHQVTS ASVSSHTTPSQFRLKESPAGHTWLISPRRRGVS KWIQPHVFTSHISYYC*SLQHSSTV*ALSPKRPG FGKSRIP*LQH*QLC**TFPTQLRSF*PGSSSL PRTHF*DWFPKQKWRWTSDPREKLRPGISDRVQ LDVCLLPFECYASSRWTVSRISSSGG*EAFTFGW GILFPCRRIFQQI*TWLNERPLSWILVTWW*KG L*RSPICPPEPTTEEKSIPAGVPKTETRS*GKF CWWGR*LCTEQKQVCRSWARQQ*LRFRHWCPWCA GILSPNSIFPSQKILPISFLYVPFGGGKPIRFQ RHFFISLQTSREYQQ*VDGSHISRTTPRRREHP QGPPKQREGGPKGRALSHMGE*HHRERLRPCRWR RPRDIKLSTL*RSNSLQPFQIQLPGEMRNCWSL AIGVCSGSQIVLVILCH*DAVFAYSFSSLGNKS SSACPQVINYARR*IR*SKTDILLPLVS*KEYMV KR*RKKNVGYYKCSPAI*GTCSRPYSFPPNFV* LLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYS YRTTALRPGNPPSHGSSESSLSSTSYSSPAHPVS TDSLAPFTGTPGYFSSQPHSGNSTGSNLPRRSC PSSAASPTLQGPSDSPTSDSVSQSSTGTLSSTS FPQNSRSSLPSDLRTISLPSAGQSAVYQASRVSA VSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTG LS*GFWIWANRTE*AHSCFLPAASGT*AEHIAE ERGVQGARGLGLVDKKQDLWSQLASGLGESCKSC LKQRL*RSFSLLSRVHC*QANGVSVSNGSKCNE LC*SLRLPSLPVARSHLCSEDIFLNLKKKKKKV FKGKKVKRANLKAPSHLSTVRVLCT*EKR*VCKC SS*DNHSKSRYLANVCPPRILFIFVLRSPRNRQ G**SLEPAPTGGCLAL*RKAHGQLLIIREQII* VDCLSLQLLPSYSPFPSYFTAQ*PMK*VDKKRRN ET*YRPIALLLTSFWQ*ISLGRIPSGLGMLRIL FFLLPINQELMIP*AGPPP*LGSMHL*LQGKSG KIGLWSGTDRTVIVCGPAPHFSGGCLCESGPSER VTKPPTPLTLFWMRDESRPASPHQCIVPVVHPW RSPGASPGGVHNLFKFHMVASLFLSLVYCNIWR VFIYLILYSVITMVGVVNI*QV*SLVLQWTFFSF GQDNTVSFPPSFPLICFPFFPSLLHPLLFYP

Frame 1

RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCP PSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS YSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQ RHGCRGLPYATIIPRSDLNGLPSPVEERCGDSP NSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRG KVIRLHRRKQDNISGGDSSATESWDEELSPSTVL YTATQHTPTSITLTVRRTKPKKRKKSPEKGRAA PKTKKIKNSPSEAQNLDENTTEGWENRIRLWTD QYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTI LDTINKTELACNNTVIGSQMQLQLGRVTRVQKH RKILRAARDLALDTLIIEYRGKVMLRQQFEVNG HFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARF IRRSCTPNAEVRHMIADGMIHLCIYAVSAITKD AEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQK RNPNATELPLLPPPPSLPTIGAETRRRKARRKEL EMEQQNEASEENNDQQSQEVPEKVTVSSDHEEV DNPEEKPEEEKEEVIDDQENLAHSRRTREDRKV EAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTT SETPVGEETKTEAPESEVSNSVSNVTIPSTPQS VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRP KSRISRYRTSSAQRLKRQKQANAQQAELSQAALE EGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQ ECPVECPLRITTDPTVLATTLNMLPGLIHSPLIC TTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKK RWIKQALEEGMTQTSSVPQETRTQHLYQSNENS SSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLR PLSPVTPPPPNSGSKSPQLATPGSSHPGEEECR NGYSLMFSPVTSLTTASRCNTPLQFELCHRKDL DLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPS LGPTSETGFPSRSGDGHQTLVRNSDQAFRTEFN LMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLD GGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERA CEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENS AGGGGDSAQSKSKSAGAGQGSSNSVSDTGAHGV QGSSARTPSSPHKKFSPSHSSMSHLEAVSPSDSR GTSSSHCRPQENISSRWMVPTSVERLREGGSIP KVLRSSVRVAQKGEPSPTWESNITEKDSDPADG EGPETLSSALSKGATVYSPSRYSYQVR*EIAGL* P*ECVLGPKLSWSSFAIEMLSLHIVSAALEISH HLLVLR**IMPEDEYGDQRQTFYCLWFPKKNTW LKDEEKRM*GIINVHQPFKGLVRVLIRFLPTLSS SCSVIVLGQNHKASFSRVPPPSEDILHSLQDTV IELLH*DLETPPLTVLQNHPSLPRPIPAPPTLC PQTRWPHLRGHQGILAASHILETALAAIFQGGAA LLVLLALPCRDPQTRQPQIQFLSPAQEL*VPPP FLRTLGRHCHQTYGLSVCPVLGSQLSTRPPGYL RFPIHSTTHTVGVGVCTSTDSSHCKGQESRLRRD FPRASGFGQTELNEPIAASFQLPLEPRPSILLR NGGYKVPEDWVWWTRNKTCGHNWPLALEKAVNL V*SRDYKEVSPCCQGYIVDKQMVFRLVTVLSAMS CVEASVSHPCL*PVVTCAVRTSF*I*KKKKKKF SKEKKLKEPISKPQAI*VLLGFYALKKKGRYVN VHPKTTIPKAGIWPMCVHQEYCLSLS*DHQEIGK DSKAWNLHQLEGAWLFEEKLMVSS*LFGSRLFE *IV*ASNCYHPTPPSQAISQLSNP*SK*TRKGG MRHDIGQLHCYLPAFGNKFH*EGYRVVWECFEFY FFYSQLIRS**SHEQDRLHDWGACTCDCRVRVG R*VCGVAPTGL*LCVGLPHISLGDAYVRVGPVK ELPSHPHP*HCSG*EMRADRLLPISALCLLYTPG GALEPAQVGYTIFLNSIWLPAYFFHLFTVISGV FLFI*FCIQL*PW*G**IYDRCNPWCCSGPSFL LDKIIL*VSLLPSL*FVFLFSPASCIPFFST

Frame 2

GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAP PPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR *FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP TQIWLLDQTLNLWRLVQQLMRRACIPLIIMGPL RGMGVEDCLMLRSSLVLT*MACRRL*RNAVETAR TLKEKLYLPGVLVVFLRMASFSTVTSAGE*AGG RLLDFIGGSRTTYQVGIAVQQKAGMRSFLLPLC CIQQHSTHLQASP*LLEEPNPRSGKRVQKRVVQH QRRRKSRILPLKHRI*MRIQLRAGKIG*DYGLT SMKKLSLISTVQMYRTRLNNTYILARNLWANLL F*TLLIRLNWPVITQLLVPKCSYSWEESLVFKST GRS*GLQEIWLWTLL**SIVGKSCYDSNLRSMG ISSKNHTPLCSSTQNSMV*RCVWMPVLSVMMLG SSEDHVHQMQRCDT*LQMG*FTCASMLCLPSPRM LRSP*HLIMSIVTVIIKWTVPVTRETGIVLYKK GILMLQNCHSYHLLQAYPPLEQRLDVEKHDGKS *RWSSRMRLQRRIMTSNHKKFQKK*LYPVIMRK* TIQKKNQKKRKKRL*MTRRT*LIAGGPGKIER* KPSCMLLKT*RKERSGGISPWNRATLM*RLLQP PQRLLLVKRQKLKPLNLKLATLFQMLPSQAPHRV LV*IPGGLPKQGILLQKN*SPSHLQQSLLGPGR RVEFLGTGPVQPKD*SVRSRPMHSRQNCHKLPW KREEVTV**LLLKLEV*TVQEKTGH*QGLTQLWC QLLDPMSTVLHLNTPKPKSI*LQNG*MTKQRSK SALLSALYVSQRIQLYWQRP*TCYQVLSIPR*F APPPNTTFALAHPLSLRDVEGPFCLMAHSAPVRS AG*NKP*KKG*LKHHLYPKRLELSTYTKAMRIV ALLVSAKTMQTC*AH*RNGSLAI*WSRMSPSYF GLCLQSHHPLPIQAQRVPSWPHLAHLTQEKRSVE MDTASCFHQSHLLLLLVAATLLYSLSFVTEKTW IWQK*DTLTPTLTAVLIDLPYSTQVILTWLLIP PSDPLLRLVSQAEVEMDIRPS*ETQTRHFGQSST *CMPTPL*MLCLEQMDCIEDLL*WGIGSLYIWM GDIVPLQKDFPADMNMA**KTSLVDPCHLVVKG PVKESHLPPRTHHRGKKYPCWSTENGNKKLRKIL LVGEVTLHRAKASLQELGKAAVTPFPTLVPMVC RDPQPELHLPLTKNSPHLIPLCPIWRR*AHQIP EALLHLTADLKRISAVGGWFPHQ*NDSEKEGASP RSSEAA*GWPKRESPLPHGRVTSQRKTQTLQME KAQRH*AQHSLKEQQFTALPDTATR*DEKLLVS SHRSVFWVPNCPGHPLPLRCCLCI*FQQPWK*VI ICLSSGNKLCQKMNTVIKDRHFTAFGFLKRIHG *KMKKKECRVL*MFTSHLRDLFASLFVSSQLCL APAV**SSDRITKPPSAEFLPLQRTSYTVSRIQL SNYCTETWKPPLSRFFRIIPLFHVLFQPRPPCV HRLVGPIYGDTRVF*QPATFWKQHWQQSSKEEL PF*CC*PYPAGTLRLANLRFSFSVQHRNSEFHLL SSEL*VVIAIRLTDYQSAQCWAVSCLPGLQGIC GFQFTALPTPWEWGCAPVPTPATARVRSQDSDG TFLGLLDLGKQN*MSP*LLPSSCLWNLGRAYC*G TGGTRCQRIGSGGQETRLVVTIGLWPWRKL*IL SEAETIKKFLPAVKGTLLTSKWCFG**RF*VQ* VVLKPPSPILACSP*SLVQ*GHLFKFKKKKKKSF QRKKS*KSQSQSPKPSEYC*GFMHLRKKVGM*M FILRQPFQKQVSGQCVSTKNTVYLCLKITKK*A RIVKLGTCTNWRVPGSLKKSSWSALDYSGADYLS RLSEPPTVTILLPLPKLFHSSVTHEVSRQEKEE *DMI*ANCIATYQLLAINFIRKDTEWFGNASNF IFSTPN*SGVDDPMSRTASMIGEHALVTAG*EWE DRFVEWHRQDCDCVWACPTFLWGMLM*EWAQ*K SYQATHTPNTVLDER*EQTGFSPSVHCACCTPL EEPWSQPRWGTQSF*IPYGCQLISFTCLL*YLAC FYLSNFVFSYNHGRGSEYMTGVIPGAAVDLLFF WTR*YCEFPSFLPSNLFSFFPQPLASPSFLP

Sequence XM_931376

GCGGCCGCCGCCCGCCTGCGCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCC CCCTCCCCGCCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGGC CTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAACTACTAGCAGAT AATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGG TCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCT ACTCAGATATGGCTGCTGGATCAGAAAAGGAAGTGGAAGCCCCCTACCTTTCAAGACGAAGTGGCACTACACCAGGATGTGAAAGTCCAGCGAAAGAGAC CCAAGGGGCCTAGGGGGCAGCACACCCCCAGAAGCCAAGTCTATTCCAGGCAGTACCAGGGATTAGGGTCTGGGCTGGAAAAATCCTGGTGTTTTGAATA TGTTCAGGTCCAGTTCAGACTCTTGATCCCACAGCCACTTCTTGAGTGAGCCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATT CCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGT AGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGAC AAGTGCAGGGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATG AGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAA GAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACGAAGAAAATCAAGGCATTTCGAGAGGGATCCCGGAAGTCCTTGCGGATGAAGAATTCTCCCTCTGAA GCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACCAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAG ATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAA TAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTG GACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCT ACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCG ACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGT AACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTACCAC CTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAA TAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAA GAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAGAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAA GAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGA AGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGG GATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCC AAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGA AGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCT AAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGG ATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTACATTCGCTTTGGCTCACC CTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACT CAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTAGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGT TGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTC AGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCT CTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGCTTTGTCACCGAAAAGACCTGGATTTGGCAAAAGTAGGATACCTTGACTCCAACACTA ACAGCTGTGCTGATAGACCTTCCCTACTCAACTCAGGTCATTCTGACCTGGCTCCTCATCCCTCCCTCGGACCCACTTCTGAGACTGGTTTCCCAAGCAG AAGTGGAGATGGACATCAGACCCTCGTGAGAAACTCAGACCAGGCATTTCGGACAGAGTTCAACTTGATGTATGCCTACTCCCCTTTGAATGCTATGCCT CGAGCAGATGGACTGTATCGAGGATCTCCTCTAGTGGGGGATAGGAAGCCTTTACATTTGGATGGGGGATATTGTTCCCCTGCAGAAGGATTTTCCAGCA GATATGAACATGGCTTAATGAAAGACCTCTCTCGTGGATCCTTGTCACCTGGTGGTGAAAGGGCCTGTGAAGGAGTCCCATCTGCCCCCCAGAACCCACC ACAGAGGAAAAAAGTATCCCTGCTGGAGTACCGAAAACGGAAACAAGAAGCTAAGGAAAATTCTGCTGGTGGGGGAGGTGACTCTGCACAGAGCAAAAGC AAGTCTGCAGGAGCTGGGCAAGGCAGCAGTAACTCCGTTTCCGACACTGGTGCCCATGGTGTGCAGGGATCCTCAGCCCGAACTCCATCTTCCCCTCACA AAAAATTCTCCCCATCTCATTCCTCTATGTCCCATTTGGAGGCGGTAAGCCCATCAGATTCCAGAGGCACTTCTTCATCTCACTGCAGACCTCAAGAGAA TATCAGCAGTAGGTGGATGGTTCCCACATCAGTAGAACGACTCCGAGAAGGAGGGAGCATCCCCAAGGTCCTCCGAAGCAGCGTGAGGGTGGCCCAAAAG GGAGAGCCCTCTCCCACATGGGAGAGTAACATCACAGAGAAAGACTCAGACCCTGCAGATGGAGAAGGCCCAGAGACATTAAGCTCAGCACTCTCTAAAG GAGCAACAGTTTACAGCCCTTCCAGATACAGCTACCAGCTCCTGCAGTGTGATAGTCCTCGGACAGAATCACAAAGCCTCCTTCAGCAGAGTTCCTCCCC CTTCAGAGGACATCCTACACAGTCTCCAGGATACAGTTATCGAACTACTGCACTGAGACCTGGAAACCCCCCCTCTCACGGTTCTTCAGAATCATCCCTC TCTTCCACGTCCTATTCCAGCCCCGCCCACCCTGTGTCCACAGACTCGTTGGCCCCATTTACGGGGACACCAGGGTATTTTAGCAGCCAGCCACATTCTG GAAACAGCACTGGCAGCAATCTTCCAAGGAGGAGCTGCCCTTCTAGTGCTGCTAGCCCTACCCTGCAGGGACCCTCAGACTCGCCAACCTCAGATTCAGT TTCTCAGTCCAGCACAGGAACTCTGAGTTCCACCTCCTTTCCTCAGAACTCTAGGTCGTCATTGCCATCAGACTTACGGACTATCAGTCTGCCCAGTGCT GGGCAGTCAGCTGTCTACCAGGCCTCCAGGGTATCTGCGGTTTCCAATTCACAGCACTACCCACACCGTGGGAGTGGGGGTGTGCACCAGTACCGACTCC AGCCACTGCAAGGGTCAGGAGTCAAGACTCAGACGGGACTTTCCTAGGGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCC AGCTGCCTCTGGAACCTAGGCCGAGCATATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCA CAATTGGCCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACATTGTTGACAAGCAA ATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATCCTTGCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGA CATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAAAAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGG GTTTTATGCACTTAAGAAAAAAGGTAGGTATGTAAATGTTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATAC TGTTTATCTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTTGAAGAAAAGCTCA TGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTACCATCCTACTCCCCCTTCCCAAGCTATTTCACAGCT CAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATGATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAG GAAGGATACCGAGTGGTTTGGGAATGCTTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATT GGGGAGCATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCCTGCCCCACATTTC TCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAACACTGTTCTGGATGAGAGATGAGAGCAGACCGGCTT CTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCTGGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAG CTTATTTCTTTCACTTGTTTACTGTAATATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAG GTGTAATCCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGTTTTCCTTTTTTCC CCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCTCTTTGTGTGTGACTGTTACAAAATTTCACTTTTCAA AATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTTTTTTTTTTTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTC CCCCACAAACCCATCAGTCTGGGAGAGCATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCT CTCCATTTGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGGCACGTGCAGAGAC CCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGGGGGTGGGGGGAACTCTTGGAAGGGAAGAAGTATCAC TTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTTTCACAAGAGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATA AAGTTGAGAA

refseq_SETD5.F5 (forward primer)
refseq_SETD5.R5 (reverse primer)
Single exon skipping

Frame 0

AAAARLRSETHAAPVPPVRQHSSAGPPLSLALP PLPAFGSLRLSAPHPHLTGTGHSRPGNAVAPRWA *LESCRLPGVPCAAARAQAPAAPGTRSSELLAD NLGGLHIQKSI*RIPHVHNMLDEALQLTPTLRV VSLH*LDPVISNLCCVGRHEHCNPSGSHHIRYIL LRYGCWIRKGSGSPLPFKTKWHYTRM*KSSERD PRGLGGSTPPEAKSIPGSTRD*GLGWKNPGVLN MFRSSSDS*SHSHFLSEP*ICGG*SSS**EERVF HS*LWDHSEAWVSRTALCYDHPSF*PEWPAVAC RGTLWRQPEL*RRNCTYLVSLWSFSGWLPSQL* QVQGNEQGEGY*TSSAEAGQHIRWG*QCNRKLG* GAFSFHCVVYSNTAHTYKHHLNC*KNQTQEAEK ESRKGSCSTKDEENQGISRGIPEVLADEEFSL* STEFR*EYN*GLGKSDKTMD*PV*RSFH*SVQCR CTERA*TTPTF*QGICGQTYYFRHY**D*IGL* *HSYWFPNAVTAGKSHSCSKAPEDPEGCKRFGF GHSYNRVSWESHVTTAI*GQWAFLQKTIPLCALL LKIQWCRDVCGCPYFR**CSVHQKIMYTKCRGA THDCRWDDSPVHLCCVCHHQGC*GHHSI*L*V* *L*L*SGLCLSQGKPELSYTKKES*CYRTATPTT SSKPTHHWSRD*T*KSTTERARDGAAE*GFRGE **PAITRSSRKSNCIQ*S*GSRQSRRKTRRRER RGYR*PGEPSS*QEDQGR*KGRSHHACF*KLREK KEAAGSALGTEQL*CRDYYNHLRDSCW*RDKN* SP*I*S*QLCFKCYHPKHPTECWCEYPEVFPSR GYCCRKTSPQATSSKAF*APAEESNFSVQDQFSP KTKASEAGQCTAGRIVTSCLGRGRK*QFSNSY* SWKSRQFRRKQAINRV*PNCGVNYWIPCQPCCI *IPQNQKVSSYRMVE*QSREARVPC*VPFTYHNG SNCTGNDPKHVTRSYPFPVNLHHPQTLHSLWLT LYP*ETSKAPSA*WHIQLL*EALDKTSLRRRDD SNIICTPRD*NSAPIPKQ*E**LF*YLQRQCRLV EPIKEMEVSLSDGAECHQVTSASVSSHTTPSQF RLKESPAGHTWLISPRRRGVSKWIQPHVFTSHI SYYC*SLQHSSTV*ALSPKRPGFGKSRIP*LQH* QLC**TFPTQLRSF*PGSSSLPRTHF*DWFPKQ KWRWTSDPREKLRPGISDRVQLDVCLLPFECYA SSRWTVSRISSSGG*EAFTFGWGILFPCRRIFQQ I*TWLNERPLSWILVTWW*KGL*RSPICPPEPT TEEKSIPAGVPKTETRS*GKFCWWGR*LCTEQK QVCRSWARQQ*LRFRHWCPWCAGILSPNSIFPSQ KILPISFLYVPFGGGKPIRFQRHFFISLQTSRE YQQ*VDGSHISRTTPRRREHPQGPPKQREGGPK GRALSHMGE*HHRERLRPCRWRRPRDIKLSTL*R SNSLQPFQIQLPAPAV**SSDRITKPPSAEFLP LQRTSYTVSRIQLSNYCTETWKPPLSRFFRIIP LFHVLFQPRPPCVHRLVGPIYGDTRVF*QPATFW KQHWQQSSKEELPF*CC*PYPAGTLRLANLRFS FSVQHRNSEFHLLSSEL*VVIAIRLTDYQSAQC WAVSCLPGLQGICGFQFTALPTPWEWGCAPVPTP ATARVRSQDSDGTFLGLLDLGKQN*MSP*LLPS SCLWNLGRAYC*GTGGTRCQRIGSGGQETRLVV TIGLWPWRKL*ILSEAETIKKFLPAVKGTLLTSK WCFG**RF*VQ*VVLKPPSPILACSP*SLVQ*G HLFKFKKKKKKSFQRKKS*KSQSQSPKPSEYC* GFMHLRKKVGM*MFILRQPFQKQVSGQCVSTKNT VYLCLKITKK*ARIVKLGTCTNWRVPGSLKKSS WSALDYSGADYLSRLSEPPTVTILLPLPKLFHS SVTHEVSRQEKEE*DMI*ANCIATYQLLAINFIR KDTEWFGNASNFIFSTPN*SGVDDPMSRTASMI GEHALVTAG*EWEDRFVEWHRQDCDCVWACPTF LWGMLM*EWAQ*KSYQATHTPNTVLDER*EQTGF SPSVHCACCTPLEEPWSQPRWGTQSF*IPYGCQ LISFTCLL*YLACFYLSNFVFSYNHGRGSEYMT GVIPGAAVDLLFFWTR*YCEFPSFLPSNLFSFFP QPLASPSFLPCPTTIICTVFSLCV*LLQNFTFQ NRNQVFAQMRGDFFFFFFFKC*DLSRVLFFLLF PPQTHQSGRALGVEIMLPGMLVSLYII*NVCKCL SIWAGVCILPLAI*PRGEASGQAALTLPGTCRD PSHSVWAGCCQDQTSWGGRGGGVGGTLGREEVS LLSQVECLHLAVTFELSQEM**F***NS*P**S* S*E

Frame 1

RPPPACAQRLTQPQSRQSANTVVPAPLFPWPCP PSPPLARSAFLPPTPTSRVRAIPGQETPWRRVG PNSSPAASRECRAPQPGPRPRQRLGQGLQNY*QI IWGDFIFRSLYKGFLMSITCWMRLCSSPPLSEW SVSINWTP*FPISAVLDVMSIAIPLGVTTSDTS YSDMAAGSEKEVEAPYLSRRSGTTPGCESPAKET QGA*GAAHPQKPSLFQAVPGIRVWAGKILVF*I CSGPVQTLDPTATS*VSPESVEASPAVNEKSVY STHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPV EERCGDSPNSEGETVPTWCPCGLSQDGFLLNCD KCRGMSRGKVIRLHRRKQDNISGGDSSATESWD EELSPSTVLYTATQHTPTSITLTVRRTKPKKRKK SPEKGRAAPKTKKIKAFREGSRKSLRMKNSPSE AQNLDENTTEGWENRIRLWTDQYEEAFTNQYSA DVQNALEQHLHSSKEFVGKPTILDTINKTELACN NTVIGSQMQLQLGRVTRVQKHRKILRAARDLAL DTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLF YSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVR HMIADGMIHLCIYAVSAITKDAEVTIAFDYEYS NCNYKVDCACHKGNRNCPIQKRNPNATELPLLP PPPSLPTIGAETRRRKARRKELEMEQQNEASEEN NDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKE EVIDDQENLAHSRRTREDRKVEAIMHAFENLEK RKKRRDQPLEQSNSDVEITTTTSETPVGEETKTE APESEVSNSVSNVTIPSTPQSVGVNTRRSSQAG DIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSA QRLKRQKQANAQQAELSQAALEEGGSNSLVTPTE AGSLDSSGENRPLTGSDPTVVSITGSHVNRAAS KYPKTKKYLVTEWLNDKAEKQECPVECPLRITT DPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSP FIPERRRRPLLPDGTFSSCKKRWIKQALEEGMT QTSSVPQETRTQHLYQSNENSSSSSICKDNADL LSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNS GSKSPQLATPGSSHPGEEECRNGYSLMFSPVTS LTTASRCNTPLQFELCHRKDLDLAKVGYLDSNT NSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSR SGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMP RADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSS RYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPP QRKKVSLLEYRKRKQEAKENSAGGGGDSAQSKS KSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPH KKFSPSHSSMSHLEAVSPSDSRGTSSSHCRPQEN ISSRWMVPTSVERLREGGSIPKVLRSSVRVAQK GEPSPTWESNITEKDSDPADGEGPETLSSALSK GATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSP FRGHPTQSPGYSYRTTALRPGNPPSHGSSESSL SSTSYSSPAHPVSTDSLAPFTGTPGYFSSQPHS GNSTGSNLPRRSCPSSAASPTLQGPSDSPTSDSV SQSSTGTLSSTSFPQNSRSSLPSDLRTISLPSA GQSAVYQASRVSAVSNSQHYPHRGSGGVHQYRL QPLQGSGVKTQTGLS*GFWIWANRTE*AHSCFLP AASGT*AEHIAEERGVQGARGLGLVDKKQDLWS QLASGLGESCKSCLKQRL*RSFSLLSRVHC*QA NGVSVSNGSKCNELC*SLRLPSLPVARSHLCSED IFLNLKKKKKKVFKGKKVKRANLKAPSHLSTVR VLCT*EKR*VCKCSS*DNHSKSRYLANVCPPRI LFIFVLRSPRNRQG**SLEPAPTGGCLAL*RKAH GQLLIIREQII*VDCLSLQLLPSYSPFPSYFTA Q*PMK*VDKKRRNET*YRPIALLLTSFWQ*ISL GRIPSGLGMLRILFFLLPINQELMIP*AGPPP*L GSMHL*LQGKSGKIGLWSGTDRTVIVCGPAPHF SGGCLCESGPSERVTKPPTPLTLFWMRDESRPA SPHQCIVPVVHPWRSPGASPGGVHNLFKFHMVAS LFLSLVYCNIWRVFIYLILYSVITMVGVVNI*Q V*SLVLQWTFFSFGQDNTVSFPPSFPLICFPFF PSLLHPLLFYPVLQLSYAQSSLFVCDCYKISLFK IEIRCLLK*GEIFFFFFFLNAETSAEYFSFCCF PHKPISLGEHWEWKSCCLGCWFLCILYKTYVNV SPFGLGFAFSPWLFNQGERPAGRRPSPCLARAET PATLCGQGAVKTRPLGGVGAGGWGELLEGKKYH FFLKWSVYTLL*HLNFHKRCNNFDNKILNHNNH KVE

Frame 2

GRRPPALRDSRSPSPASPPTQ*CRPPSFPGPAP PPRLWLAPPFCPPPPPHGYGPFPARKRRGAALG LTRVLPPPGSAVRRSPGPGPGSAWDKVFRTTSR *FGGTSYSEVYIKDSSCP*HVG*GSAAHPHSQSG QSPLIGPRDFQSLLCWTS*ALQSLWESPHQIHP TQIWLLDQKRKWKPPTFQDEVALHQDVKVQRKR PKGPRGQHTPRSQVYSRQYQGLGSGLEKSWCFEY VQVQFRLLIPQPLLE*ALNLWRLVQQLMRRACI PLIIMGPLRGMGVEDCLMLRSSLVLT*MACRRL *RNAVETARTLKEKLYLPGVLVVFLRMASFSTVT SAGE*AGGRLLDFIGGSRTTYQVGIAVQQKAGM RSFLLPLCCIQQHSTHLQASP*LLEEPNPRSGK RVQKRVVQHQRRRKSRHFERDPGSPCG*RILPLK HRI*MRIQLRAGKIG*DYGLTSMKKLSLISTVQ MYRTRLNNTYILARNLWANLLF*TLLIRLNWPV ITQLLVPKCSYSWEESLVFKSTGRS*GLQEIWLW TLL**SIVGKSCYDSNLRSMGISSKNHTPLCSS TQNSMV*RCVWMPVLSVMMLGSSEDHVHQMQRC DT*LQMG*FTCASMLCLPSPRMLRSP*HLIMSIV TVIIKWTVPVTRETGIVLYKKGILMLQNCHSYH LLQAYPPLEQRLDVEKHDGKS*RWSSRMRLQRR IMTSNHKKFQKK*LYPVIMRK*TIQKKNQKKRKK RL*MTRRT*LIAGGPGKIER*KPSCMLLKT*RK ERSGGISPWNRATLM*RLLQPPQRLLLVKRQKL KPLNLKLATLFQMLPSQAPHRVLV*IPGGLPKQG ILLQKN*SPSHLQQSLLGPGRRVEFLGTGPVQP KD*SVRSRPMHSRQNCHKLPWKREEVTV**LLL KLEV*TVQEKTGH*QGLTQLWCQLLDPMSTVLHL NTPKPKSI*LQNG*MTKQRSKSALLSALYVSQR IQLYWQRP*TCYQVLSIPR*FAPPPNTTFALAH PLSLRDVEGPFCLMAHSAPVRSAG*NKP*KKG*L KHHLYPKRLELSTYTKAMRIVALLVSAKTMQTC *AH*RNGSLAI*WSRMSPSYFGLCLQSHHPLPI QAQRVPSWPHLAHLTQEKRSVEMDTASCFHQSHL LLLLVAATLLYSLSFVTEKTWIWQK*DTLTPTL TAVLIDLPYSTQVILTWLLIPPSDPLLRLVSQA EVEMDIRPS*ETQTRHFGQSST*CMPTPL*MLCL EQMDCIEDLL*WGIGSLYIWMGDIVPLQKDFPA DMNMA**KTSLVDPCHLVVKGPVKESHLPPRTH HRGKKYPCWSTENGNKKLRKILLVGEVTLHRAKA SLQELGKAAVTPFPTLVPMVCRDPQPELHLPLT KNSPHLIPLCPIWRR*AHQIPEALLHLTADLKR ISAVGGWFPHQ*NDSEKEGASPRSSEAA*GWPKR ESPLPHGRVTSQRKTQTLQMEKAQRH*AQHSLK EQQFTALPDTATSSCSVIVLGQNHKASFSRVPP PSEDILHSLQDTVIELLH*DLETPPLTVLQNHPS LPRPIPAPPTLCPQTRWPHLRGHQGILAASHIL ETALAAIFQGGAALLVLLALPCRDPQTRQPQIQ FLSPAQEL*VPPPFLRTLGRHCHQTYGLSVCPVL GSQLSTRPPGYLRFPIHSTTHTVGVGVCTSTDS SHCKGQESRLRRDFPRASGFGQTELNEPIAASF QLPLEPRPSILLRNGGYKVPEDWVWWTRNKTCGH NWPLALEKAVNLV*SRDYKEVSPCCQGYIVDKQ MVFRLVTVLSAMSCVEASVSHPCL*PVVTCAVR TSF*I*KKKKKKFSKEKKLKEPISKPQAI*VLLG FYALKKKGRYVNVHPKTTIPKAGIWPMCVHQEY CLSLS*DHQEIGKDSKAWNLHQLEGAWLFEEKL MVSS*LFGSRLFE*IV*ASNCYHPTPPSQAISQL SNP*SK*TRKGGMRHDIGQLHCYLPAFGNKFH* EGYRVVWECFEFYFFYSQLIRS**SHEQDRLHD WGACTCDCRVRVGR*VCGVAPTGL*LCVGLPHIS LGDAYVRVGPVKELPSHPHP*HCSG*EMRADRL LPISALCLLYTPGGALEPAQVGYTIFLNSIWLP AYFFHLFTVISGVFLFI*FCIQL*PW*G**IYDR CNPWCCSGPSFLLDKIIL*VSLLPSL*FVFLFS PASCIPFFSTLSYNYHMHSLLSLCVTVTKFHFS KSKSGVCSNEGRFFFFFFF*MLRPQQSTFLFVVS PTNPSVWESIGSGNHVAWDAGFFVYYIKRM*MS LHLGWGLHSPLGYLTKGRGQRAGGPHPAWHVQR PQPLCVGRVLSRPDLLGG*GRGGGGNSWKGRSIT SFSSGVFTPCCNI*TFTRDVIILIIKFLTIIII KLR