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Sequences

Sequence NM_001013031

CTCCCGCGATGGGAAAAGTTGGCGCCGGCGGCGGCTCCCAAGCCCGGCTGAGCGCGCTCCTCGCCGGCGCGGGGCTCTTGATCCTCTGCGCCCCGGGCGT CTGCGGCGGCGGCTCCTGCTGCCCCTCGCCGCACCCCAGCTCCGCTCCACGCTCGGCCTCGACCCCTAGGGGCTTTTCCCACCAGGGGCGGCCAGGCAGG GCTCCTGCCACGCCCCTGCCCCTCGTAGTGCGTCCCCTGTTCTCAGTGGCCCCCGGGGACCGAGCGCTATCCCTGGAGCGGGCTCGGGGCACTGGGGCAT CCATGGCGGTTGCTGCACGCTCCGGCCGGAGGAGACGGAGCGGAGCGGATCAGGAGAAGGCAGAACGGGGAGAGGGCGCGAGTCGGAGCCCCCGGGGAGT GCTAAGAGATGGAGGGCAGCAGGAGCCTGGGACTCGGGAGCGGGACCCGGACAAAGCCACCCGCTTCCGGATGGAGGAGCTGAGACTGACCAGCACCACG TTTGCGCTGACGGGAGACTCAGCACACAACCAAGCCATGGTCCACTGGTCTGGCCACAACAGCAGCGTGATTCTCATTTTGACAAAGCTCTATGACTATA ACCTGGGGAGCATCACAGAGAGCTCGCTTTGGAGGTCAACCGATTATGGAACAACCTATGAGAAGCTGAATGATAAAGTTGGTTTGAAAACCATTTTGAG CTATCTCTATGTGTGTCCTACCAACAAGCGTAAGATAATGTTACTCACAGACCCGGAGATTGAGAGCAGTTTATTGATCAGCTCAGATGAAGGGGCAACT TATCAAAAGTACCGGCTGAACTTCTACATTCAAAGCTTGCTTTTTCACCCCAAACAAGAAGACTGGATTCTGGCATACAGTCAAGACCAAAAGTTATACA GCTCTGCTGAATTTGGGAGAAGATGGCAGCTTATCCAAGAAGGGGTTGTACCAAACAGGTTCTACTGGTCTGTGATGGGGTCAAATAAAGAACCAGACCT TGTGCATCTTGAGGCCAGAACTGTGGATGGTCATTCACATTATCTAACTTGCCGAATGCAGAACTGTACAGAGGCCAACAGGAATCAGCCTTTTCCAGGC TACATTGACCCAGACTCTTTGATTGTTCAGGATCATTATGTGTTTGTTCAGCTGACATCAGGAGGGCGGCCACATTACTACGTGTCCTACCGAAGGAATG CATTTGCCCAAATGAAGCTTCCGAAATATGCTTTGCCCAAGGACATGCATGTTATCAGCACCGATGAGAATCAGGTGTTCGCAGCGGTCCAAGAATGGAA CCAGAATGACACGTACAACCTCTACATCTCAGACACACGTGGTGTCTACTTCACCCTGGCCTTGGAGAATGTCCAGAGCAGCAGAGGCCCTGAGGGCAAC ATCATGATCGACCTCTATGAGGTAGCAGGGATAAAGGGAATGTTCTTGGCTAACAAGAAGATTGACAACCAAGTGAAGACTTTCATCACATATAACAAAG GCAGAGACTGGCGTTTGCTGCAGGCGCCGGACACGGATCTAAGGGGGGACCCCGTGCACTGCTTGCTGCCCTATTGCTCACTACACCTTCACCTGAAGGT CTCTGAGAATCCCTACACATCAGGGATCATTGCCAGCAAAGACACAGCTCCAAGCATCATAGTGGCATCAGGTAATATAGGTTCTGAATTGTCAGACACT GACATCAGCATGTTTGTCTCTTCAGATGCAGGGAACACCTGGAGACAGATCTTTGAAGAAGAGCACAGTGTTTTGTACCTGGATCAAGGTGGAGTCCTGG TTGCTATGAAACACACATCTCTCCCAATTCGACATCTTTGGTTGAGTTTTGATGAAGGGAGATCTTGGAGCAAATACAGTTTCACATCTATTCCACTTTT TGTGGATGGGGTTCTGGGTGAGCCTGGAGAAGAGACTCTCATCATGACAGTGTTTGGACACTTCAGCCACCGCTCTGAATGGCAGCTGGTCAAAGTAGAT TACAAGTCCATTTTTGATAGACGGTGTGCCGAAGAGGACTACAGACCTTGGCAGCTGCACAGCCAGGGGGAAGCATGTATCATGGGAGCAAAAAGGATAT ATAAGAAGCGAAAATCAGAGCGGAAGTGTATGCAAGGAAAATATGCAGGAGCTATGGAATCTGAACCCTGTGTCTGCACTGAGGCTGATTTTGATTGCGA CTATGGTTATGAGCGACACAGCAATGGCCAGTGCCTGCCGGCATTTTGGTTCAATCCATCCTCTCTGTCAAAGGATTGCAGCTTGGGACAGAGTTACCTC AATAGTACTGGGTACAGGAAGGTGGTTTCCAATAATTGCACTGATGGCGTAAGGGAACAGTACACTGCCAAACCGCAGAAGTGCCCAGGGAAAGCCCCGC GGGGGCTGCGGATAGTCACGGCTGATGGAAAGCTGACAGCGGAACAAGGACACAACGTCACTCTCATGGTGCAATTAGAAGAGGGTGATGTTCAGCGGAC ACTCATCCAAGTGGACTTTGGCGATGGTATCGCGGTGTCTTACGTCAATCTCAGCTCCATGGAAGATGGGATCAAACACGTCTATCAGAACGTGGGCATT TTCCGTGTGACCGTGCAGGTGGACAACAGTCTGGGTTCTGACAGCGCCGTCCTGTACTTACATGTAACTTGTCCCTTGGAGCACGTGCACCTGTCTCTTC CCTTTGTCACCACAAAGAACAAAGAGGTCAATGCGACGGCAGTGCTGTGGCCCAGCCAAGTGGGCACCCTCACTTACGTGTGGTGGTACGGAAACAACAC GGAGCCTTTGATCACCTTGGAGGGAAGCATATCCTTCAGATTTACTTCAGAAGGAATGAATACCATCACAGTGCAGGTCTCAGCTGGGAATGCCATCCTA CAAGACACAAAGACCATCGCAGTATATGAGGAATTCCGGTCTCTTCGCTTGTCCTTTTCTCCAAACCTGGATGACTACAACCCGGACATCCCTGAGTGGA GGAGGGACATCGGTCGAGTCATCAAAAAATCCCTGGTGGAAGCCACAGGGGTTCCAGGCCAGCACATCCTGGTGGCGGTGCTCCCTGGCTTACCCACCAC TGCTGAACTCTTTGTCCTACCCTATCAGGATCCAGCTGGAGAAAACAAAAGGTCAACTGATGACCTGGAGCAGATATCAGAATTGCTGATCCACACGCTC AACCAAAACTCAGTACACTTCGAGCTGAAGCCAGGAGTCCGAGTCCTTGTCCATGCTGCTCACTTAACAGCGGCCCCCCTGGTGGACCTCACTCCAACCC ACAGTGGATCTGCCATGCTGATGCTGCTCTCAGTGGTGTTTGTGGGGCTGGCAGTGTTCGTCATCTACAAGTTTAAAAGGAAGATCCCGGGGATTAATGT TTATGCCCAGATGCAGAATGAGAAAGAACAAGAGATGATCAGTCCAGTCAGTCACTCTGAAAGCAGGCCCAATGTCCCTCAGACTGAACTAAGGAGGCCT GGCCAGCTTATAGATGAGAAGGTGGAATCCCAGCTCATAGGAAGTATTTCCATAGTTGCTGAGAATCAAAGCACAAAAGAAATCCCTACCTATGTAAATG TTTGAATGGAGGACGCCAGTAAAAAAACAAAAACAAAAACAAAACAAAACATAAAATATAAACAATCAAAATCCAAACAAACAAACAAACACTCACTGCA TCGGGACTTTTTAATTCTTCAGACACAGACAACAAGGGTTTTTAGCTTTAAGCCTGTGCATGTGGACAATACTCTGAGAACATGTCTGGAGGGGCAGTGT ACAGGTGCTCTATTTTAATGGAAAACACTCCCCTCTCCCTCTTTCTTCTTCTCTCTCTTTTTTCTGATCGGTCGTGTTTGTAGAAAATTCATAACATATA TAGGCCAAGGAAATCTGCATGTATTTTTGGAAATATTCTTGGCTCTAGATTTATCAGCTATTTTAGCATTAAAGGCTGATGGGTGGATTAGCTACCCCAG CTCCTTTCATAAGACACAAAGACGTGCACAGGAGTTTGAAACCCTGAGCTGTTTCTCTGTTCCACTTTCCATACTGTCATTTCCCTTCTAAGTTAGCTTT GGTAGCTCTGTTGGTCAGCAGTGGCCACAAGGCTGCTTTCTGCACTCTCTGTGGCCACAGGAACAAAGATGCGAGTTGAAGATCCCTTTGTGCCGGTAGA ATAAGGAAGGAAGGGAGGCAGGGAGGCAAAGCATGTCAGAAACGGACCTTGGTTTCCTGTTCACCTCTTTCCACCATGATTGCCTCCCCTTGCAGCTTTC CCTACTCCTGCCCCAACTGCAGTAGGAAATGGAATCCCATTAGTTACCCATTGTCCTGTCTTCACATTTGTTTGTCATCCATGTGTGACCATGATCTGTT GATATCTTTGAATCTCTTCCCTCCAAACCCCAAGTAAGTTGTCCTTCAACTGTTCTCAGTTTTTCTTCCCAAACATATTGCTAGATTCTGGACATTAACC CTGACGTTTCCTAAATACTGGCCTGGCCTGTGCCGCCCCTGCCCCCACTACTCACAAGTTTCTGAGCCCTTTGTCAGTTTTGTACATTCCCAAGCATGCC AGCTTCTGTGCCCATGGACCTTGCTGCATCCTGCACAGCAGGGTTCAGTTTCATGTATCTTTGTCTTTTCCTCTAGAACCTGCCTTTTTCAAATATCCCT GCCTTTTCCCACCTGGAAACATATACTGTATGCGAAAGAGTTGATATATGCAAAGTAATTCAAACCTGGCCATGTACTTTGGAAAAGAAAGCATAGAGAT GAATTGTGGTGTTCTCACACCTTAACGAAAATCTCGTGCGATCTGATTCCAGAAGATTCTTGTGAGAAATGTTTTGAATGTGTGACAATTTCGCAGGGCA ATTTCCTCCTGTGACGGTTGCTGTTACCTGGTATTTCCACTCTCACAGTAGAATAGAAATGTTTGTGAAATAAAACTGATTTTAACTGGAAGGAGAAACA GGTTAATGGACTTTGTGTTTAAGAGTGTCAAACAGTCTGAGAGAATAAATGGGGGTCTTGTCTTACATTAGGGTGAGAGTTTGATTATTTAGGATGATCC CAGTGATTTCATGTGTGCTCTCTGACCTCTGAGTATCATAGTATCATTAAAGTAAAGATTTAAGTCTGTATAAAGGAGGAGAGTTACTGATTGGCAAAAA AGATTGGCACAAAGCATGAAGAAACCCCATTTTTCCCAGGGTAATCATGAAAGAAGGCTCAGAGAAAGAGGGAAACAAAAGCCTGTTCAGCAGAGGCCCC TTTAGTATTATGGACTGGGCAAAGCCCACTATAAACTATAGGAGAAAGAAGTTCTGATAAACCTCTTAGTATGCTCAGCCTCCTTCTTTGCTATGTCCCT AAGCCAACAGGGTATAACACAGGCCCTGGTGATAATGAGGGTGTCCTAAAGATCCTGATGTCCATGACTTCATGTAGTTCAGGCACAGAAAGAATAGCAA AGCTGCTGTCAGAAGTTTGTCAGGCAGAGATGTTTATGGTTGAGGATACCCCATATGAATCTGGGAAATGGGCTAGGCCTGAGGCAGTCACCTATTTGTA GAACTCAATTGATCCCCAACCTGCCAGGCTTCCTATCTCATAGGAAACATCCTCATTGATCCTCTTCAGTTGGAGTCTCCCAAATTTAATGTGGAAGACA AAGTGTTGGAAAATCAAAAGAGGCTCACTCAAACCAGCACAGGGAGTCCTCAGAGTTGCAGTTCAATTCATTTTAATTAGAAAAGTATGAAAGAGGTATA ACACTCTTATTCTAGCACAGTGCCTTGCCTAGAGTAGTAGTATGAAAACTATTTGTTGAAGAAATAAATGAATGGAAAGACATAGGGAAGAATGGGCTGT AAATCCTAATTAAAAATAGAGGTCGACATGAGATACCTGGCATTTTGGGAAGTGACCAAAGATGGCCAGCTAGAGATTCAGCATCTCCAGGATCCTCATG TGCCTCTCCTCAAAGCTCCCTCCCATCTGTAGGAGATTAGTGAGGCAAGGTGCTGCTCAGAGAGGAGGACCTCATTGTTCTTAGGACCTTGGCCAGTTGT TCTCAAAGTGTGGTACCTGGATCAGCAGTATCACTATCACTTGGGCTAGTTAGAGATCCAGATTCTGGATCCATACCCCATACCTACTGAATTAGAAACT CTAGGGGATGAATAGTGGTGTTCTCTGTTGCTAAGTGACAGTGGGCCCAGCCACCTATTTTAACAAGCCCTCCCAGTGATTGTGATACATACTAAAGTTT GAGAACCATTGTACTAGGCCATTCCAGCTGAATCTCAAACAGAAGGCAGTAATGAGAGCCTACAAATGGGAGGGACCTAAGTGCCTACCTACTCGCTAAT CGCAGGTGCAAACACACAAGGAGTTTGGTGGGCTTAAGGTCAGAGGAGTGTGTAGGGAGGGATGTATGTGGAAGGTAAGATTCAGGGCAAGCTAAAAATC CGATACTGCAACGTTTTCCAAAATCCCAGAAGGCAAACTGTGCATGTTCTACCCTGAACCACCCAAGCAACACTTTCTACCTTGCCTTATTTTTAATTGG ATTCACTGTCCAAAATGCAGAGGTTTGCTTTGCTTTTTTTTCAGAAGTTCCAAACAGCAACTTTGAGAGCAGTGGGGTGCTTGGCAGCTGTTCTGTGTTT TCCAGGAATCCAACTGAGCATTGAAATCTCTCATTTGCCGACTTATTTTTATAGGAAGCCAATTAAAAAAAAAAAAAGTTTTCTTATAGTATTGGAACTA CTTCTAATTTTAAAATGACTTTTTTGATGTATTTTTTGTTAAATACTATGTAGTGTAATGTATAATTGCTCTTGTTTATTGCTTTTACAATCATATTTAT TAAACAGATAATGTCTCTAAAGTCTTTGCCTCAGGTATTTTTTTTTTTAATCCTAAACCCTTGGTGTTCATTCTAAATATAGAAGTGTTGCATGTATAGG ATTTCATAAAGGCTAATTGCATAAGAAAGAGTAAACACCACAGGCTTGAGGTTTTTGGCTGTTTTTTACTAACAAGGCAGAATGTATGTACTACCTGAAT TCTACCTGCATTTCAATTAACTATACAATGTCTGTTTATTAAATTACTTTGATTTAAAAATTA

refseq_SORCS1.F1 (forward primer)
refseq_SORCS1.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

LPRWEKLAPAAAPKPG*ARSSPARGS*SSAPRA SAAAAPAAPRRTPAPLHARPRPLGAFPTRGGQAG LLPRPCPS*CVPCSQWPPGTERYPWSGLGALGH PWRLLHAPAGGDGAERIRRRQNGERARVGAPGE C*EMEGSRSLGLGSGTRTKPPASGWRS*D*PAPR LR*RETQHTTKPWSTGLATTAA*FSF*QSSMTI TWGASQRARFGGQPIMEQPMRS*MIKLV*KPF* AISMCVLPTSVR*CYSQTRRLRAVY*SAQMKGQL IKSTG*TSTFKACFFTPNKKTGFWHTVKTKSYT ALLNLGEDGSLSKKGLYQTGSTGL*WGQIKNQT LCILRPELWMVIHII*LAECRTVQRPTGISLFQA TLTQTL*LFRIIMCLFS*HQEGGHITTCPTEGM HLPK*SFRNMLCPRTCMLSAPMRIRCSQRSKNG TRMTRTTSTSQTHVVSTSPWPWRMSRAAEALRAT S*STSMR*QG*RECSWLTRRLTTK*RLSSHITK AETGVCCRRRTRI*GGTPCTACCPIAHYTFT*R SLRIPTHQGSLPAKTQLQAS*WHQVI*VLNCQTL TSACLSLQMQGTPGDRSLKKSTVFCTWIKVESW LL*NTHLSQFDIFG*VLMKGDLGANTVSHLFHF LWMGFWVSLEKRLSS*QCLDTSATALNGSWSK*I TSPFLIDGVPKRTTDLGSCTARGKHVSWEQKGY IRSENQSGSVCKENMQELWNLNPVSALRLILIA TMVMSDTAMASACRHFGSIHPLCQRIAAWDRVTS IVLGTGRWFPIIALMA*GNSTLPNRRSAQGKPR GGCG*SRLMES*QRNKDTTSLSWCN*KRVMFSG HSSKWTLAMVSRCLTSISAPWKMGSNTSIRTWAF SV*PCRWTTVWVLTAPSCTYM*LVPWSTCTCLF PLSPQRTKRSMRRQCCGPAKWAPSLTCGGTETT RSL*SPWREAYPSDLLQKE*IPSQCRSQLGMPSY KTQRPSQYMRNSGLFACPFLQTWMTTTRTSLSG GGTSVESSKNPWWKPQGFQASTSWWRCSLAYPP LLNSLSYPIRIQLEKTKGQLMTWSRYQNC*STRS TKTQYTSS*SQESESLSMLLT*QRPPWWTSLQP TVDLPC*CCSQWCLWGWQCSSSTSLKGRSRGLM FMPRCRMRKNKR*SVQSVTLKAGPMSLRLN*GGL ASL*MRRWNPSS*EVFP*LLRIKAQKKSLPM*M FEWRTPVKKQKQKQNKT*NINNQNPNKQTNTHC IGTF*FFRHRQQGFLALSLCMWTIL*EHVWRGSV QVLYFNGKHSPLPLSSSLSFF*SVVFVENS*HI *AKEICMYFWKYSWL*IYQLF*H*RLMGGLATP APFIRHKDVHRSLKP*AVSLFHFPYCHFPSKLAL VALLVSSGHKAAFCTLCGHRNKDAS*RSLCAGR IRKEGRQGGKACQKRTLVSCSPLSTMIASPCSF PYSCPNCSRKWNPISYPLSCLHICLSSMCDHDLL ISLNLFPPNPK*VVLQLFSVFLPKHIARFWTLT LTFPKYWPGLCRPCPHYSQVSEPFVSFVHSQAC QLLCPWTLLHPAQQGSVSCIFVFSSRTCLFQISL PFPTWKHILYAKELIYAK*FKPGHVLWKRKHRD ELWCSHTLTKISCDLIPEDSCEKCFECVTISQG NFLL*RLLLPGISTLTVE*KCL*NKTDFNWKEKQ VNGLCV*ECQTV*ENKWGSCLTLG*EFDYLG*S Q*FHVCSLTSEYHSIIKVKI*VCIKEESY*LAK KIGTKHEETPFFPG*S*KKAQRKRETKACSAEAP LVLWTGQSPL*TIGERSSDKPLSMLSLLLCYVP KPTGYNTGPGDNEGVLKILMSMTSCSSGTERIA KLLSEVCQAEMFMVEDTPYESGKWARPEAVTYL* NSIDPQPARLPIS*ETSSLILFSWSLPNLMWKT KCWKIKRGSLKPAQGVLRVAVQFILIRKV*KRY NTLILAQCLA*SSSMKTIC*RNK*MERHREEWAV NPN*K*RST*DTWHFGK*PKMAS*RFSISRILM CLSSKLPPICRRLVRQGAAQRGGPHCS*DLGQL FSKCGTWISSITITWAS*RSRFWIHTPYLLN*KL *GMNSGVLCC*VTVGPATYFNKPSQ*L*YILKF ENHCTRPFQLNLKQKAVMRAYKWEGPKCLPTR* SQVQTHKEFGGLKVRGVCREGCMWKVRFRAS*KS DTATFSKIPEGKLCMFYPEPPKQHFLPCLIFNW IHCPKCRGLLCFFFRSSKQQL*EQWGAWQLFCV FQESN*ALKSLICRLIFIGSQLKKKKVFL*YWNY F*F*NDFFDVFFVKYYVV*CIIALVYCFYNHIY *TDNVSKVFASGIFFFNPKPLVFILNIEVLHV* DFIKANCIRKSKHHRLEVFGCFLLTRQNVCTT*I LPAFQLTIQCLFIKLL*FKN

Frame 1

SRDGKSWRRRRLPSPAERAPRRRGALDPLRPGR LRRRLLLPLAAPQLRSTLGLDP*GLFPPGAARQ GSCHAPAPRSASPVLSGPRGPSAIPGAGSGHWGI HGGCCTLRPEETERSGSGEGRTGRGRESEPPGS AKRWRAAGAWDSGAGPGQSHPLPDGGAETDQHH VCADGRLSTQPSHGPLVWPQQQRDSHFDKAL*L* PGEHHRELALEVNRLWNNL*EAE**SWFENHFE LSLCVSYQQA*DNVTHRPGD*EQFIDQLR*RGN LSKVPAELLHSKLAFSPQTRRLDSGIQSRPKVIQ LC*IWEKMAAYPRRGCTKQVLLVCDGVK*RTRP CAS*GQNCGWSFTLSNLPNAELYRGQQESAFSR LH*PRLFDCSGSLCVCSADIRRAATLLRVLPKEC ICPNEASEICFAQGHACYQHR*ESGVRSGPRME PE*HVQPLHLRHTWCLLHPGLGECPEQQRP*GQ HHDRPL*GSRDKGNVLG*QED*QPSEDFHHI*QR QRLAFAAGAGHGSKGGPRALLAALLLTTPSPEG L*ESLHIRDHCQQRHSSKHHSGIR*YRF*IVRH *HQHVCLFRCREHLETDL*RRAQCFVPGSRWSPG CYETHISPNSTSLVEF**REILEQIQFHIYSTF CGWGSG*AWRRDSHHDSVWTLQPPL*MAAGQSR LQVHF**TVCRRGLQTLAAAQPGGSMYHGSKKDI *EAKIRAEVYARKICRSYGI*TLCLH*G*F*LR LWL*ATQQWPVPAGILVQSILSVKGLQLGTELP Q*YWVQEGGFQ*LH*WRKGTVHCQTAEVPRESPA GAADSHG*WKADSGTRTQRHSHGAIRRG*CSAD THPSGLWRWYRGVLRQSQLHGRWDQTRLSERGH FPCDRAGGQQSGF*QRRPVLTCNLSLGARAPVSS LCHHKEQRGQCDGSAVAQPSGHPHLRVVVRKQH GAFDHLGGKHILQIYFRRNEYHHSAGLSWECHP TRHKDHRSI*GIPVSSLVLFSKPG*LQPGHP*VE EGHRSSHQKIPGGSHRGSRPAHPGGGAPWLTHH C*TLCPTLSGSSWRKQKVN**PGADIRIADPHA QPKLSTLRAEARSPSPCPCCSLNSGPPGGPHSNP QWICHADAALSGVCGAGSVRHLQV*KEDPGD*C LCPDAE*ERTRDDQSSQSL*KQAQCPSD*TKEA WPAYR*EGGIPAHRKYFHSC*ESKHKRNPYLCKC LNGGRQ*KNKNKNKTKHKI*TIKIQTNKQTLTA SGLFNSSDTDNKGF*L*ACACGQYSENMSGGAV YRCSILMENTPLSLFLLLSLFSDRSCL*KIHNIY RPRKSACIFGNILGSRFISYFSIKG*WVD*LPQ LLS*DTKTCTGV*NPELFLCSTFHTVISLLS*L W*LCWSAVATRLLSALSVATGTKMRVEDPFVPVE *GRKGGREAKHVRNGPWFPVHLFPP*LPPLAAF PTPAPTAVGNGIPLVTHCPVFTFVCHPCVTMIC *YL*ISSLQTPSKLSFNCSQFFFPNILLDSGH*P *RFLNTGLACAAPAPTTHKFLSPLSVLYIPKHA SFCAHGPCCILHSRVQFHVSLSFPLEPAFFKYP CLFPPGNIYCMRKS*YMQSNSNLAMYFGKESIEM NCGVLTP*RKSRAI*FQKILVRNVLNV*QFRRA ISSCDGCCYLVFPLSQ*NRNVCEIKLILTGRRN RLMDFVFKSVKQSERINGGLVLH*GESLII*DDP SDFMCAL*PLSIIVSLK*RFKSV*RRRVTDWQK RLAQSMKKPHFSQGNHERRLRERGKQKPVQQRP L*YYGLGKAHYKL*EKEVLINLLVCSASFFAMSL SQQGITQALVIMRVS*RS*CP*LHVVQAQKE*Q SCCQKFVRQRCLWLRIPHMNLGNGLGLRQSPIC RTQLIPNLPGFLSHRKHPH*SSSVGVSQI*CGRQ SVGKSKEAHSNQHRESSELQFNSF*LEKYERGI TLLF*HSALPRVVV*KLFVEEINEWKDIGKNGL *ILIKNRGRHEIPGILGSDQRWPARDSASPGSSC ASPQSSLPSVGD**GKVLLREEDLIVLRTLASC SQSVVPGSAVSLSLGLVRDPDSGSIPHTY*IRN SRG*IVVFSVAK*QWAQPPILTSPPSDCDTY*SL RTIVLGHSS*ISNRRQ**EPTNGRDLSAYLLAN RRCKHTRSLVGLRSEECVGRDVCGR*DSGQAKN PILQRFPKSQKANCACSTLNHPSNTFYLALFLIG FTVQNAEVCFAFFSEVPNSNFESSGVLGSCSVF SRNPTEH*NLSFADLFL*EAN*KKKKFSYSIGT TSNFKMTFLMYFLLNTM*CNV*LLLFIAFTIIFI KQIMSLKSLPQVFFFLILNPWCSF*I*KCCMYR IS*RLIA*ERVNTTGLRFLAVFY*QGRMYVLPE FYLHFN*LYNVCLLNYFDLKI

Frame 2

PAMGKVGAGGGSQARLSALLAGAGLLILCAPGV CGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGR APATPLPLVVRPLFSVAPGDRALSLERARGTGA SMAVAARSGRRRRSGADQEKAERGEGASRSPRGV LRDGGQQEPGTRERDPDKATRFRMEELRLTSTT FALTGDSAHNQAMVHWSGHNSSVILILTKLYDY NLGSITESSLWRSTDYGTTYEKLNDKVGLKTILS YLYVCPTNKRKIMLLTDPEIESSLLISSDEGAT YQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLY SSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDL VHLEARTVDGHSHYLTCRMQNCTEANRNQPFPG YIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRN AFAQMKLPKYALPKDMHVISTDENQVFAAVQEWN QNDTYNLYISDTRGVYFTLALENVQSSRGPEGN IMIDLYEVAGIKGMFLANKKIDNQVKTFITYNK GRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKV SENPYTSGIIASKDTAPSIIVASGNIGSELSDT DISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVL VAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLF VDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVD YKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRI YKKRKSERKCMQGKYAGAMESEPCVCTEADFDCD YGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYL NSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAP RGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRT LIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGI FRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSL PFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNT EPLITLEGSISFRFTSEGMNTITVQVSAGNAIL QDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEW RRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTT AELFVLPYQDPAGENKRSTDDLEQISELLIHTL NQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPT HSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINV YAQMQNEKEQEMISPVSHSESRPNVPQTELRRP GQLIDEKVESQLIGSISIVAENQSTKEIPTYVN V*MEDASKKTKTKTKQNIKYKQSKSKQTNKHSLH RDFLILQTQTTRVFSFKPVHVDNTLRTCLEGQC TGALF*WKTLPSPSFFFSLFFLIGRVCRKFITY IGQGNLHVFLEIFLALDLSAILALKADGWISYPS SFHKTQRRAQEFETLSCFSVPLSILSFPF*VSF GSSVGQQWPQGCFLHSLWPQEQRCELKIPLCR* NKEGREAGRQSMSETDLGFLFTSFHHDCLPLQLS LLLPQLQ*EMESH*LPIVLSSHLFVIHV*P*SV DIFESLPSKPQVSCPSTVLSFSSQTYC*ILDIN PDVS*ILAWPVPPLPPLLTSF*ALCQFCTFPSMP ASVPMDLAASCTAGFSFMYLCLFL*NLPFSNIP AFSHLETYTVCERVDICKVIQTWPCTLEKKA*R *IVVFSHLNENLVRSDSRRFL*EMF*MCDNFAGQ FPPVTVAVTWYFHSHSRIEMFVK*N*F*LEGET G*WTLCLRVSNSLRE*MGVLSYIRVRV*LFRMI PVISCVLSDL*VS*YH*SKDLSLYKGGELLIGKK DWHKA*RNPIFPRVIMKEGSEKEGNKSLFSRGP FSIMDWAKPTINYRRKKF**TS*YAQPPSLLCP *ANRV*HRPW***GCPKDPDVHDFM*FRHRKNSK AAVRSLSGRDVYG*GYPI*IWEMG*A*GSHLFV ELN*SPTCQASYLIGNILIDPLQLESPKFNVED KVLENQKRLTQTSTGSPQSCSSIHFN*KSMKEV* HSYSSTVPCLE**YENYLLKK*MNGKT*GRMGC KS*LKIEVDMRYLAFWEVTKDGQLEIQHLQDPH VPLLKAPSHL*EISEARCCSERRTSLFLGPWPVV LKVWYLDQQYHYHLG*LEIQILDPYPIPTELET LGDE*WCSLLLSDSGPSHLF*QALPVIVIHTKV *EPLY*AIPAESQTEGSNESLQMGGT*VPTYSLI AGANTQGVWWA*GQRSV*GGMYVEGKIQGKLKI RYCNVFQNPRRQTVHVLP*TTQATLSTLPYF*L DSLSKMQRFALLFFQKFQTATLRAVGCLAAVLCF PGIQLSIEISHLPTYFYRKPIKKKKSFLIVLEL LLILK*LF*CIFC*ILCSVMYNCSCLLLLQSYL LNR*CL*SLCLRYFFF*S*TLGVHSKYRSVACIG FHKG*LHKKE*TPQA*GFWLFFTNKAECMYYLN STCISINYTMSVY*ITLI*KL

Sequence NM_052918

CTCCCGCGATGGGAAAAGTTGGCGCCGGCGGCGGCTCCCAAGCCCGGCTGAGCGCGCTCCTCGCCGGCGCGGGGCTCTTGATCCTCTGCGCCCCGGGCGT CTGCGGCGGCGGCTCCTGCTGCCCCTCGCCGCACCCCAGCTCCGCTCCACGCTCGGCCTCGACCCCTAGGGGCTTTTCCCACCAGGGGCGGCCAGGCAGG GCTCCTGCCACGCCCCTGCCCCTCGTAGTGCGTCCCCTGTTCTCAGTGGCCCCCGGGGACCGAGCGCTATCCCTGGAGCGGGCTCGGGGCACTGGGGCAT CCATGGCGGTTGCTGCACGCTCCGGCCGGAGGAGACGGAGCGGAGCGGATCAGGAGAAGGCAGAACGGGGAGAGGGCGCGAGTCGGAGCCCCCGGGGAGT GCTAAGAGATGGAGGGCAGCAGGAGCCTGGGACTCGGGAGCGGGACCCGGACAAAGCCACCCGCTTCCGGATGGAGGAGCTGAGACTGACCAGCACCACG TTTGCGCTGACGGGAGACTCAGCACACAACCAAGCCATGGTCCACTGGTCTGGCCACAACAGCAGCGTGATTCTCATTTTGACAAAGCTCTATGACTATA ACCTGGGGAGCATCACAGAGAGCTCGCTTTGGAGGTCAACCGATTATGGAACAACCTATGAGAAGCTGAATGATAAAGTTGGTTTGAAAACCATTTTGAG CTATCTCTATGTGTGTCCTACCAACAAGCGTAAGATAATGTTACTCACAGACCCGGAGATTGAGAGCAGTTTATTGATCAGCTCAGATGAAGGGGCAACT TATCAAAAGTACCGGCTGAACTTCTACATTCAAAGCTTGCTTTTTCACCCCAAACAAGAAGACTGGATTCTGGCATACAGTCAAGACCAAAAGTTATACA GCTCTGCTGAATTTGGGAGAAGATGGCAGCTTATCCAAGAAGGGGTTGTACCAAACAGGTTCTACTGGTCTGTGATGGGGTCAAATAAAGAACCAGACCT TGTGCATCTTGAGGCCAGAACTGTGGATGGTCATTCACATTATCTAACTTGCCGAATGCAGAACTGTACAGAGGCCAACAGGAATCAGCCTTTTCCAGGC TACATTGACCCAGACTCTTTGATTGTTCAGGATCATTATGTGTTTGTTCAGCTGACATCAGGAGGGCGGCCACATTACTACGTGTCCTACCGAAGGAATG CATTTGCCCAAATGAAGCTTCCGAAATATGCTTTGCCCAAGGACATGCATGTTATCAGCACCGATGAGAATCAGGTGTTCGCAGCGGTCCAAGAATGGAA CCAGAATGACACGTACAACCTCTACATCTCAGACACACGTGGTGTCTACTTCACCCTGGCCTTGGAGAATGTCCAGAGCAGCAGAGGCCCTGAGGGCAAC ATCATGATCGACCTCTATGAGGTAGCAGGGATAAAGGGAATGTTCTTGGCTAACAAGAAGATTGACAACCAAGTGAAGACTTTCATCACATATAACAAAG GCAGAGACTGGCGTTTGCTGCAGGCGCCGGACACGGATCTAAGGGGGGACCCCGTGCACTGCTTGCTGCCCTATTGCTCACTACACCTTCACCTGAAGGT CTCTGAGAATCCCTACACATCAGGGATCATTGCCAGCAAAGACACAGCTCCAAGCATCATAGTGGCATCAGGTAATATAGGTTCTGAATTGTCAGACACT GACATCAGCATGTTTGTCTCTTCAGATGCAGGGAACACCTGGAGACAGATCTTTGAAGAAGAGCACAGTGTTTTGTACCTGGATCAAGGTGGAGTCCTGG TTGCTATGAAACACACATCTCTCCCAATTCGACATCTTTGGTTGAGTTTTGATGAAGGGAGATCTTGGAGCAAATACAGTTTCACATCTATTCCACTTTT TGTGGATGGGGTTCTGGGTGAGCCTGGAGAAGAGACTCTCATCATGACAGTGTTTGGACACTTCAGCCACCGCTCTGAATGGCAGCTGGTCAAAGTAGAT TACAAGTCCATTTTTGATAGACGGTGTGCCGAAGAGGACTACAGACCTTGGCAGCTGCACAGCCAGGGGGAAGCATGTATCATGGGAGCAAAAAGGATAT ATAAGAAGCGAAAATCAGAGCGGAAGTGTATGCAAGGAAAATATGCAGGAGCTATGGAATCTGAACCCTGTGTCTGCACTGAGGCTGATTTTGATTGCGA CTATGGTTATGAGCGACACAGCAATGGCCAGTGCCTGCCGGCATTTTGGTTCAATCCATCCTCTCTGTCAAAGGATTGCAGCTTGGGACAGAGTTACCTC AATAGTACTGGGTACAGGAAGGTGGTTTCCAATAATTGCACTGATGGCGTAAGGGAACAGTACACTGCCAAACCGCAGAAGTGCCCAGGGAAAGCCCCGC GGGGGCTGCGGATAGTCACGGCTGATGGAAAGCTGACAGCGGAACAAGGACACAACGTCACTCTCATGGTGCAATTAGAAGAGGGTGATGTTCAGCGGAC ACTCATCCAAGTGGACTTTGGCGATGGTATCGCGGTGTCTTACGTCAATCTCAGCTCCATGGAAGATGGGATCAAACACGTCTATCAGAACGTGGGCATT TTCCGTGTGACCGTGCAGGTGGACAACAGTCTGGGTTCTGACAGCGCCGTCCTGTACTTACATGTAACTTGTCCCTTGGAGCACGTGCACCTGTCTCTTC CCTTTGTCACCACAAAGAACAAAGAGGTCAATGCGACGGCAGTGCTGTGGCCCAGCCAAGTGGGCACCCTCACTTACGTGTGGTGGTACGGAAACAACAC GGAGCCTTTGATCACCTTGGAGGGAAGCATATCCTTCAGATTTACTTCAGAAGGAATGAATACCATCACAGTGCAGGTCTCAGCTGGGAATGCCATCCTA CAAGACACAAAGACCATCGCAGTATATGAGGAATTCCGGTCTCTTCGCTTGTCCTTTTCTCCAAACCTGGATGACTACAACCCGGACATCCCTGAGTGGA GGAGGGACATCGGTCGAGTCATCAAAAAATCCCTGGTGGAAGCCACAGGGGTTCCAGGCCAGCACATCCTGGTGGCGGTGCTCCCTGGCTTACCCACCAC TGCTGAACTCTTTGTCCTACCCTATCAGGATCCAGCTGGAGAAAACAAAAGGTCAACTGATGACCTGGAGCAGATATCAGAATTGCTGATCCACACGCTC AACCAAAACTCAGTACACTTCGAGCTGAAGCCAGGAGTCCGAGTCCTTGTCCATGCTGCTCACTTAACAGCGGCCCCCCTGGTGGACCTCACTCCAACCC ACAGTGGATCTGCCATGCTGATGCTGCTCTCAGTGGTGTTTGTGGGGCTGGCAGTGTTCGTCATCTACAAGTTTAAAAGGAGAGTAGCTTTACCCTCCCC TCCCTCCCCTTCTACTCAACCTGGTGACTCATCTCTCCGATTGCAAAGAGCAAGACACGCCACTCCGCCTTCAACGCCAAAGCGGGGATCTGCTGGGGCA CAGTATGCAATTTAAGGAAAACCCCCAAAGGCTACAGGCGACCTGCTGATCAGGAAAGAATTTCGCTCTTGTCAAGTACATCATCCTTCATGACCACTAA CTTTGTGTTTTTTTTCTTTCCTTTGTTGTTCTGTTTCCTATTTTGCCAGGAAGTATTTCCATAGTTGCTGAGAATCAAAGCACAAAAGAAATCCCTACCT ATGTAAATGTTTGAATGGAGGACGCCAGTAAAAAAACAAAAACAAAAACAAAACAAAACATAAAATATAAACAATCAAAATCCAAACAAACAAACAAACA CTCACTGCATCGGGACTTTTTAATTCTTCAGACACAGACAACAAGGGTTTTTAGCTTTAAGCCTGTGCATGTGGACAATACTCTGAGAACATGTCTGGAG GGGCAGTGTACAGGTGCTCTATTTTAATGGAAAACACTCCCCTCTCCCTCTTTCTTCTTCTCTCTCTTTTTTCTGATCGGTCGTGTTTGTAGAAAATTCA TAACATATATAGGCCAAGGAAATCTGCATGTATTTTTGGAAATATTCTTGGCTCTAGATTTATCAGCTATTTTAGCATTAAAGGCTGATGGGTGGATTAG CTACCCCAGCTCCTTTCATAAGACACAAAGACGTGCACAGGAGTTTGAAACCCTGAGCTGTTTCTCTGTTCCACTTTCCATACTGTCATTTCCCTTCTAA GTTAGCTTTGGTAGCTCTGTTGGTCAGCAGTGGCCACAAGGCTGCTTTCTGCACTCTCTGTGGCCACAGGAACAAAGATGCGAGTTGAAGATCCCTTTGT GCCGGTAGAATAAGGAAGGAAGGGAGGCAGGGAGGCAAAGCATGTCAGAAACGGACCTTGGTTTCCTGTTCACCTCTTTCCACCATGATTGCCTCCCCTT GCAGCTTTCCCTACTCCTGCCCCAACTGCAGTAGGAAATGGAATCCCATTAGTTACCCATTGTCCTGTCTTCACATTTGTTTGTCATCCATGTGTGACCA TGATCTGTTGATATCTTTGAATCTCTTCCCTCCAAACCCCAAGTAAGTTGTCCTTCAACTGTTCTCAGTTTTTCTTCCCAAACATATTGCTAGATTCTGG ACATTAACCCTGACGTTTCCTAAATACTGGCCTGGCCTGTGCCGCCCCTGCCCCCACTACTCACAAGTTTCTGAGCCCTTTGTCAGTTTTGTACATTCCC AAGCATGCCAGCTTCTGTGCCCATGGACCTTGCTGCATCCTGCACAGCAGGGTTCAGTTTCATGTATCTTTGTCTTTTCCTCTAGAACCTGCCTTTTTCA AATATCCCTGCCTTTTCCCACCTGGAAACATATACTGTATGCGAAAGAGTTGATATATGCAAAGTAATTCAAACCTGGCCATGTACTTTGGAAAAGAAAG CATAGAGATGAATTGTGGTGTTCTCACACCTTAACGAAAATCTCGTGCGATCTGATTCCAGAAGATTCTTGTGAGAAATGTTTTGAATGTGTGACAATTT CGCAGGGCAATTTCCTCCTGTGACGGTTGCTGTTACCTGGTATTTCCACTCTCACAGTAGAATAGAAATGTTTGTGAAATAAAACTGATTTTAACTGGAA GGAGAAACAGGTTAATGGACTTTGTGTTTAAGAGTGTCAAACAGTCTGAGAGAATAAATGGGGGTCTTGTCTTACATTAGGGTGAGAGTTTGATTATTTA GGATGATCCCAGTGATTTCATGTGTGCTCTCTGACCTCTGAGTATCATAGTATCATTAAAGTAAAGATTTAAGTCTGTATAAAGGAGGAGAGTTACTGAT TGGCAAAAAAGATTGGCACAAAGCATGAAGAAACCCCATTTTTCCCAGGGTAATCATGAAAGAAGGCTCAGAGAAAGAGGGAAACAAAAGCCTGTTCAGC AGAGGCCCCTTTAGTATTATGGACTGGGCAAAGCCCACTATAAACTATAGGAGAAAGAAGTTCTGATAAACCTCTTAGTATGCTCAGCCTCCTTCTTTGC TATGTCCCTAAGCCAACAGGGTATAACACAGGCCCTGGTGATAATGAGGGTGTCCTAAAGATCCTGATGTCCATGACTTCATGTAGTTCAGGCACAGAAA GAATAGCAAAGCTGCTGTCAGAAGTTTGTCAGGCAGAGATGTTTATGGTTGAGGATACCCCATATGAATCTGGGAAATGGGCTAGGCCTGAGGCAGTCAC CTATTTGTAGAACTCAATTGATCCCCAACCTGCCAGGCTTCCTATCTCATAGGAAACATCCTCATTGATCCTCTTCAGTTGGAGTCTCCCAAATTTAATG TGGAAGACAAAGTGTTGGAAAATCAAAAGAGGCTCACTCAAACCAGCACAGGGAGTCCTCAGAGTTGCAGTTCAATTCATTTTAATTAGAAAAGTATGAA AGAGGTATAACACTCTTATTCTAGCACAGTGCCTTGCCTAGAGTAGTAGTATGAAAACTATTTGTTGAAGAAATAAATGAATGGAAAGACATAGGGAAGA ATGGGCTGTAAATCCTAATTAAAAATAGAGGTCGACATGAGATACCTGGCATTTTGGGAAGTGACCAAAGATGGCCAGCTAGAGATTCAGCATCTCCAGG ATCCTCATGTGCCTCTCCTCAAAGCTCCCTCCCATCTGTAGGAGATTAGTGAGGCAAGGTGCTGCTCAGAGAGGAGGACCTCATTGTTCTTAGGACCTTG GCCAGTTGTTCTCAAAGTGTGGTACCTGGATCAGCAGTATCACTATCACTTGGGCTAGTTAGAGATCCAGATTCTGGATCCATACCCCATACCTACTGAA TTAGAAACTCTAGGGGATGAATAGTGGTGTTCTCTGTTGCTAAGTGACAGTGGGCCCAGCCACCTATTTTAACAAGCCCTCCCAGTGATTGTGATACATA CTAAAGTTTGAGAACCATTGTACTAGGCCATTCCAGCTGAATCTCAAACAGAAGGCAGTAATGAGAGCCTACAAATGGGAGGGACCTAAGTGCCTACCTA CTCGCTAATCGCAGGTGCAAACACACAAGGAGTTTGGTGGGCTTAAGGTCAGAGGAGTGTGTAGGGAGGGATGTATGTGGAAGGTAAGATTCAGGGCAAG CTAAAAATCCGATACTGCAACGTTTTCCAAAATCCCAGAAGGCAAACTGTGCATGTTCTACCCTGAACCACCCAAGCAACACTTTCTACCTTGCCTTATT TTTAATTGGATTCACTGTCCAAAATGCAGAGGTTTGCTTTGCTTTTTTTTCAGAAGTTCCAAACAGCAACTTTGAGAGCAGTGGGGTGCTTGGCAGCTGT TCTGTGTTTTCCAGGAATCCAACTGAGCATTGAAATCTCTCATTTGCCGACTTATTTTTATAGGAAGCCAATTAAAAAAAAAAAAAGTTTTCTTATAGTA TTGGAACTACTTCTAATTTTAAAATGACTTTTTTGATGTATTTTTTGTTAAATACTATGTAGTGTAATGTATAATTGCTCTTGTTTATTGCTTTTACAAT CATATTTATTAAACAGATAATGTCTCTAAAGTCTTTGCCTCAGGTATTTTTTTTTTTAATCCTAAACCCTTGGTGTTCATTCTAAATATAGAAGTGTTGC ATGTATAGGATTTCATAAAGGCTAATTGCATAAGAAAGAGTAAACACCACAGGCTTGAGGTTTTTGGCTGTTTTTTACTAACAAGGCAGAATGTATGTAC TACCTGAATTCTACCTGCATTTCAATTAACTATACAATGTCTGTTTATTAAATTACTTTGATTTAAAAATTA

refseq_SORCS1.F1 (forward primer)
refseq_SORCS1.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

LPRWEKLAPAAAPKPG*ARSSPARGS*SSAPRA SAAAAPAAPRRTPAPLHARPRPLGAFPTRGGQAG LLPRPCPS*CVPCSQWPPGTERYPWSGLGALGH PWRLLHAPAGGDGAERIRRRQNGERARVGAPGE C*EMEGSRSLGLGSGTRTKPPASGWRS*D*PAPR LR*RETQHTTKPWSTGLATTAA*FSF*QSSMTI TWGASQRARFGGQPIMEQPMRS*MIKLV*KPF* AISMCVLPTSVR*CYSQTRRLRAVY*SAQMKGQL IKSTG*TSTFKACFFTPNKKTGFWHTVKTKSYT ALLNLGEDGSLSKKGLYQTGSTGL*WGQIKNQT LCILRPELWMVIHII*LAECRTVQRPTGISLFQA TLTQTL*LFRIIMCLFS*HQEGGHITTCPTEGM HLPK*SFRNMLCPRTCMLSAPMRIRCSQRSKNG TRMTRTTSTSQTHVVSTSPWPWRMSRAAEALRAT S*STSMR*QG*RECSWLTRRLTTK*RLSSHITK AETGVCCRRRTRI*GGTPCTACCPIAHYTFT*R SLRIPTHQGSLPAKTQLQAS*WHQVI*VLNCQTL TSACLSLQMQGTPGDRSLKKSTVFCTWIKVESW LL*NTHLSQFDIFG*VLMKGDLGANTVSHLFHF LWMGFWVSLEKRLSS*QCLDTSATALNGSWSK*I TSPFLIDGVPKRTTDLGSCTARGKHVSWEQKGY IRSENQSGSVCKENMQELWNLNPVSALRLILIA TMVMSDTAMASACRHFGSIHPLCQRIAAWDRVTS IVLGTGRWFPIIALMA*GNSTLPNRRSAQGKPR GGCG*SRLMES*QRNKDTTSLSWCN*KRVMFSG HSSKWTLAMVSRCLTSISAPWKMGSNTSIRTWAF SV*PCRWTTVWVLTAPSCTYM*LVPWSTCTCLF PLSPQRTKRSMRRQCCGPAKWAPSLTCGGTETT RSL*SPWREAYPSDLLQKE*IPSQCRSQLGMPSY KTQRPSQYMRNSGLFACPFLQTWMTTTRTSLSG GGTSVESSKNPWWKPQGFQASTSWWRCSLAYPP LLNSLSYPIRIQLEKTKGQLMTWSRYQNC*STRS TKTQYTSS*SQESESLSMLLT*QRPPWWTSLQP TVDLPC*CCSQWCLWGWQCSSSTSLKGE*LYPP LPPLLLNLVTHLSDCKEQDTPLRLQRQSGDLLGH SMQFKENPQRLQATC*SGKNFALVKYIILHDH* LCVFFLSFVVLFPILPGSISIVAENQSTKEIPT YVNV*MEDASKKTKTKTKQNIKYKQSKSKQTNKH SLHRDFLILQTQTTRVFSFKPVHVDNTLRTCLE GQCTGALF*WKTLPSPSFFFSLFFLIGRVCRKF ITYIGQGNLHVFLEIFLALDLSAILALKADGWIS YPSSFHKTQRRAQEFETLSCFSVPLSILSFPF* VSFGSSVGQQWPQGCFLHSLWPQEQRCELKIPL CR*NKEGREAGRQSMSETDLGFLFTSFHHDCLPL QLSLLLPQLQ*EMESH*LPIVLSSHLFVIHV*P *SVDIFESLPSKPQVSCPSTVLSFSSQTYC*IL DINPDVS*ILAWPVPPLPPLLTSF*ALCQFCTFP SMPASVPMDLAASCTAGFSFMYLCLFL*NLPFS NIPAFSHLETYTVCERVDICKVIQTWPCTLEKK A*R*IVVFSHLNENLVRSDSRRFL*EMF*MCDNF AGQFPPVTVAVTWYFHSHSRIEMFVK*N*F*LE GETG*WTLCLRVSNSLRE*MGVLSYIRVRV*LF RMIPVISCVLSDL*VS*YH*SKDLSLYKGGELLI GKKDWHKA*RNPIFPRVIMKEGSEKEGNKSLFS RGPFSIMDWAKPTINYRRKKF**TS*YAQPPSL LCP*ANRV*HRPW***GCPKDPDVHDFM*FRHRK NSKAAVRSLSGRDVYG*GYPI*IWEMG*A*GSH LFVELN*SPTCQASYLIGNILIDPLQLESPKFN VEDKVLENQKRLTQTSTGSPQSCSSIHFN*KSMK EV*HSYSSTVPCLE**YENYLLKK*MNGKT*GR MGCKS*LKIEVDMRYLAFWEVTKDGQLEIQHLQ DPHVPLLKAPSHL*EISEARCCSERRTSLFLGPW PVVLKVWYLDQQYHYHLG*LEIQILDPYPIPTE LETLGDE*WCSLLLSDSGPSHLF*QALPVIVIH TKV*EPLY*AIPAESQTEGSNESLQMGGT*VPTY SLIAGANTQGVWWA*GQRSV*GGMYVEGKIQGK LKIRYCNVFQNPRRQTVHVLP*TTQATLSTLPY F*LDSLSKMQRFALLFFQKFQTATLRAVGCLAAV LCFPGIQLSIEISHLPTYFYRKPIKKKKSFLIV LELLLILK*LF*CIFC*ILCSVMYNCSCLLLLQ SYLLNR*CL*SLCLRYFFF*S*TLGVHSKYRSVA CIGFHKG*LHKKE*TPQA*GFWLFFTNKAECMY YLNSTCISINYTMSVY*ITLI*KL

Frame 1

SRDGKSWRRRRLPSPAERAPRRRGALDPLRPGR LRRRLLLPLAAPQLRSTLGLDP*GLFPPGAARQ GSCHAPAPRSASPVLSGPRGPSAIPGAGSGHWGI HGGCCTLRPEETERSGSGEGRTGRGRESEPPGS AKRWRAAGAWDSGAGPGQSHPLPDGGAETDQHH VCADGRLSTQPSHGPLVWPQQQRDSHFDKAL*L* PGEHHRELALEVNRLWNNL*EAE**SWFENHFE LSLCVSYQQA*DNVTHRPGD*EQFIDQLR*RGN LSKVPAELLHSKLAFSPQTRRLDSGIQSRPKVIQ LC*IWEKMAAYPRRGCTKQVLLVCDGVK*RTRP CAS*GQNCGWSFTLSNLPNAELYRGQQESAFSR LH*PRLFDCSGSLCVCSADIRRAATLLRVLPKEC ICPNEASEICFAQGHACYQHR*ESGVRSGPRME PE*HVQPLHLRHTWCLLHPGLGECPEQQRP*GQ HHDRPL*GSRDKGNVLG*QED*QPSEDFHHI*QR QRLAFAAGAGHGSKGGPRALLAALLLTTPSPEG L*ESLHIRDHCQQRHSSKHHSGIR*YRF*IVRH *HQHVCLFRCREHLETDL*RRAQCFVPGSRWSPG CYETHISPNSTSLVEF**REILEQIQFHIYSTF CGWGSG*AWRRDSHHDSVWTLQPPL*MAAGQSR LQVHF**TVCRRGLQTLAAAQPGGSMYHGSKKDI *EAKIRAEVYARKICRSYGI*TLCLH*G*F*LR LWL*ATQQWPVPAGILVQSILSVKGLQLGTELP Q*YWVQEGGFQ*LH*WRKGTVHCQTAEVPRESPA GAADSHG*WKADSGTRTQRHSHGAIRRG*CSAD THPSGLWRWYRGVLRQSQLHGRWDQTRLSERGH FPCDRAGGQQSGF*QRRPVLTCNLSLGARAPVSS LCHHKEQRGQCDGSAVAQPSGHPHLRVVVRKQH GAFDHLGGKHILQIYFRRNEYHHSAGLSWECHP TRHKDHRSI*GIPVSSLVLFSKPG*LQPGHP*VE EGHRSSHQKIPGGSHRGSRPAHPGGGAPWLTHH C*TLCPTLSGSSWRKQKVN**PGADIRIADPHA QPKLSTLRAEARSPSPCPCCSLNSGPPGGPHSNP QWICHADAALSGVCGAGSVRHLQV*KESSFTLP SLPFYSTW*LISPIAKSKTRHSAFNAKAGICWG TVCNLRKTPKGYRRPADQERISLLSSTSSFMTTN FVFFFFPLLFCFLFCQEVFP*LLRIKAQKKSLP M*MFEWRTPVKKQKQKQNKT*NINNQNPNKQTN THCIGTF*FFRHRQQGFLALSLCMWTIL*EHVWR GSVQVLYFNGKHSPLPLSSSLSFF*SVVFVENS *HI*AKEICMYFWKYSWL*IYQLF*H*RLMGGL ATPAPFIRHKDVHRSLKP*AVSLFHFPYCHFPSK LALVALLVSSGHKAAFCTLCGHRNKDAS*RSLC AGRIRKEGRQGGKACQKRTLVSCSPLSTMIASP CSFPYSCPNCSRKWNPISYPLSCLHICLSSMCDH DLLISLNLFPPNPK*VVLQLFSVFLPKHIARFW TLTLTFPKYWPGLCRPCPHYSQVSEPFVSFVHS QACQLLCPWTLLHPAQQGSVSCIFVFSSRTCLFQ ISLPFPTWKHILYAKELIYAK*FKPGHVLWKRK HRDELWCSHTLTKISCDLIPEDSCEKCFECVTI SQGNFLL*RLLLPGISTLTVE*KCL*NKTDFNWK EKQVNGLCV*ECQTV*ENKWGSCLTLG*EFDYL G*SQ*FHVCSLTSEYHSIIKVKI*VCIKEESY* LAKKIGTKHEETPFFPG*S*KKAQRKRETKACSA EAPLVLWTGQSPL*TIGERSSDKPLSMLSLLLC YVPKPTGYNTGPGDNEGVLKILMSMTSCSSGTE RIAKLLSEVCQAEMFMVEDTPYESGKWARPEAVT YL*NSIDPQPARLPIS*ETSSLILFSWSLPNLM WKTKCWKIKRGSLKPAQGVLRVAVQFILIRKV* KRYNTLILAQCLA*SSSMKTIC*RNK*MERHREE WAVNPN*K*RST*DTWHFGK*PKMAS*RFSISR ILMCLSSKLPPICRRLVRQGAAQRGGPHCS*DL GQLFSKCGTWISSITITWAS*RSRFWIHTPYLLN *KL*GMNSGVLCC*VTVGPATYFNKPSQ*L*YI LKFENHCTRPFQLNLKQKAVMRAYKWEGPKCLP TR*SQVQTHKEFGGLKVRGVCREGCMWKVRFRAS *KSDTATFSKIPEGKLCMFYPEPPKQHFLPCLI FNWIHCPKCRGLLCFFFRSSKQQL*EQWGAWQL FCVFQESN*ALKSLICRLIFIGSQLKKKKVFL*Y WNYF*F*NDFFDVFFVKYYVV*CIIALVYCFYN HIY*TDNVSKVFASGIFFFNPKPLVFILNIEVL HV*DFIKANCIRKSKHHRLEVFGCFLLTRQNVCT T*ILPAFQLTIQCLFIKLL*FKN

Frame 2

PAMGKVGAGGGSQARLSALLAGAGLLILCAPGV CGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGR APATPLPLVVRPLFSVAPGDRALSLERARGTGA SMAVAARSGRRRRSGADQEKAERGEGASRSPRGV LRDGGQQEPGTRERDPDKATRFRMEELRLTSTT FALTGDSAHNQAMVHWSGHNSSVILILTKLYDY NLGSITESSLWRSTDYGTTYEKLNDKVGLKTILS YLYVCPTNKRKIMLLTDPEIESSLLISSDEGAT YQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLY SSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDL VHLEARTVDGHSHYLTCRMQNCTEANRNQPFPG YIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRN AFAQMKLPKYALPKDMHVISTDENQVFAAVQEWN QNDTYNLYISDTRGVYFTLALENVQSSRGPEGN IMIDLYEVAGIKGMFLANKKIDNQVKTFITYNK GRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKV SENPYTSGIIASKDTAPSIIVASGNIGSELSDT DISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVL VAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLF VDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVD YKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRI YKKRKSERKCMQGKYAGAMESEPCVCTEADFDCD YGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYL NSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAP RGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRT LIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGI FRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSL PFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNT EPLITLEGSISFRFTSEGMNTITVQVSAGNAIL QDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEW RRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTT AELFVLPYQDPAGENKRSTDDLEQISELLIHTL NQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPT HSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSP PSPSTQPGDSSLRLQRARHATPPSTPKRGSAGA QYAI*GKPPKATGDLLIRKEFRSCQVHHPS*PL TLCFFSFLCCSVSYFARKYFHSC*ESKHKRNPYL CKCLNGGRQ*KNKNKNKTKHKI*TIKIQTNKQT LTASGLFNSSDTDNKGF*L*ACACGQYSENMSG GAVYRCSILMENTPLSLFLLLSLFSDRSCL*KIH NIYRPRKSACIFGNILGSRFISYFSIKG*WVD* LPQLLS*DTKTCTGV*NPELFLCSTFHTVISLL S*LW*LCWSAVATRLLSALSVATGTKMRVEDPFV PVE*GRKGGREAKHVRNGPWFPVHLFPP*LPPL AAFPTPAPTAVGNGIPLVTHCPVFTFVCHPCVT MIC*YL*ISSLQTPSKLSFNCSQFFFPNILLDSG H*P*RFLNTGLACAAPAPTTHKFLSPLSVLYIP KHASFCAHGPCCILHSRVQFHVSLSFPLEPAFF KYPCLFPPGNIYCMRKS*YMQSNSNLAMYFGKES IEMNCGVLTP*RKSRAI*FQKILVRNVLNV*QF RRAISSCDGCCYLVFPLSQ*NRNVCEIKLILTG RRNRLMDFVFKSVKQSERINGGLVLH*GESLII* DDPSDFMCAL*PLSIIVSLK*RFKSV*RRRVTD WQKRLAQSMKKPHFSQGNHERRLRERGKQKPVQ QRPL*YYGLGKAHYKL*EKEVLINLLVCSASFFA MSLSQQGITQALVIMRVS*RS*CP*LHVVQAQK E*QSCCQKFVRQRCLWLRIPHMNLGNGLGLRQS PICRTQLIPNLPGFLSHRKHPH*SSSVGVSQI*C GRQSVGKSKEAHSNQHRESSELQFNSF*LEKYE RGITLLF*HSALPRVVV*KLFVEEINEWKDIGK NGL*ILIKNRGRHEIPGILGSDQRWPARDSASPG SSCASPQSSLPSVGD**GKVLLREEDLIVLRTL ASCSQSVVPGSAVSLSLGLVRDPDSGSIPHTY* IRNSRG*IVVFSVAK*QWAQPPILTSPPSDCDTY *SLRTIVLGHSS*ISNRRQ**EPTNGRDLSAYL LANRRCKHTRSLVGLRSEECVGRDVCGR*DSGQ AKNPILQRFPKSQKANCACSTLNHPSNTFYLALF LIGFTVQNAEVCFAFFSEVPNSNFESSGVLGSC SVFSRNPTEH*NLSFADLFL*EAN*KKKKFSYS IGTTSNFKMTFLMYFLLNTM*CNV*LLLFIAFTI IFIKQIMSLKSLPQVFFFLILNPWCSF*I*KCC MYRIS*RLIA*ERVNTTGLRFLAVFY*QGRMYV LPEFYLHFN*LYNVCLLNYFDLKI