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Sequences

Sequence NM_001002235

TGGGCAGGAACTGGGCACTGTGCCCAGGGCATGCACTGCCTCCACGCAGCAACCCTCAGAGTCCTGAGCTGAACCAAGAAGGAGGAGGGGGTCGGGCCTC CGAGGAAGGCCTAGCCGCTGCTGCTGCCAGGAATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGCCAGAAGAG ACAGAGCTTGAGGAGAGCTTGAGGAGAGCAGGAAAGGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCCCT GTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTTCAACAAGATCACCCCCAACC TGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGAGCATCGCTACAGCCTTTGCAAT GCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCTCAGATCCATGAAGGCTTC CAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCAATGGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGT TTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAAGAGGCCAAGAAACAGATCAACGATTACGTGGAGAA GGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGCTTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAATGGGAGAGA CCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCC AGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGGAAACTACAGCACCT GGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACC TATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCT CCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATGTCTATCCCCCCCGA GGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGTGAATCCCACCCAAAAATAACTG CCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACATTAAAGAAGGGTTGAGCTGGTCCCTGCCTGCA

refseq_SERPINA1.F1 (forward primer)
refseq_SERPINA1.R1 (reverse primer)
Multiple exon skipping

Frame 0

WAGTGHCAQGMHCLHAATLRVLS*TKKEEGVGP PRKA*PLLLPGIPGWRGGNLLPAFRPLSCACQKR QSLRRA*GEQERTMPSSVSWGILLLAGLCCLVP VSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPN LAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAM LSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDK FLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEK GTQGKIVDLVKELDRDTVFALVNYIFFKGKWER PFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNI QHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHL ENELTHDIITKFLENEDRRSASLHLPKLSITGT YDLKSVLGQLGITKVFSNGADLSGVTEEAPLKL SKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPE VKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK*L PLAPQPLPSIPGPLPG*H*RRVELVPAC

Frame 1

GQELGTVPRACTASTQQPSES*AEPRRRRGSGL RGRPSRCCCQEFQVGGAATSCQPSGHSPVPARR DRA*GELEESRKGQCRLLSRGASSCWQACAAWSL SPWLRIPREMLPRRQIHPTMIRITQPSTRSPPT WLSSPSAYTASWHTSPTAPISSSPQ*ASLQPLQ CSPWGPRLTLTMKSWRA*ISTSRRFRRLRSMKAS RNSSVPSTSQTASSS*PPAMACSSARA*S*WIS FWRMLKSCTTQKPSLSTSGTPKRPRNRSTITWR RVLKGKLWIWSRSLTETQFLLW*ITSSLKANGRD PLKSRTPRKRTSTWTR*PP*RCL**SV*ACLTS STVRSCPAGCC**NTWAMPPPSSSCLMRGNYST WKMNSPTISSPSSWKMKTEGLPAYIYPNCPLLEP MI*RASWVNWASLRSSAMGLTSPGSQRRHP*SS PRPCIRLC*PSTRKGLKLLGPCF*RPYPCLSPP RSSSTNPLSS**LNKIPSLPSSWEKW*IPPKNNC LSLLNPSPPSLAPSLDDIKEGLSWSLPA

Frame 2

GRNWALCPGHALPPRSNPQSPELNQEGGGGRAS EEGLAAAAARNSRLEGRQPPASLQATLLCLPEE TELEESLRRAGKDNAVFCLVGHPPAGRPVLPGP CLPG*GSPGRCCPEDRYIPP*SGSPNLQQDHPQP G*VRLQPIPPAGTPVQQHQYLLLPSEHRYSLCN ALPGDQG*HSR*NPGGPEFQPHGDSGGSDP*RL PGTPPYPQPARQPAPADHRQWPVPQRGPEASG*V FGGC*KVVPLRSLHCQLRGHRRGQETDQRLRGE GYSRENCGFGQGA*QRHSFCSGELHLL*RQMGE TL*SQGHRGRGLPRGPGDHREGAYDEAFRHV*HP AL*EAVQLGAADEIPGQCHRHLLPA**GETTAP GK*THPRYHHQVPGK*RQKVCQLTFTQTVHYWN L*SEERPGSTGHH*GLQQWG*PLRGHRGGTPEAL QGRA*GCADHRRERD*SCWGHVFRGHTHVYPPR GQVQQTLCLLND*TKYQVSPLHGKSGESHPKIT ASRSSTPPLHPWPPPWMTLKKG*AGPCL

Sequence NM_001002236

TGGGCAGGAACTGGGCACTGTGCCCAGGGCATGCACTGCCTCCACGCAGCAACCCTCAGAGTCCTGAGCTGAACCAAGAAGGAGGAGGGGGTCGGGCCTC CGAGGAAGGCCTAGCCGCTGCTGCTGCCAGGAATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGCCAGAAGAG ACAGAGCTTGAGGAGAGCTTGAGGAGAGCAGGAAAGGGCGGCAGTAAGTCTTCAGCATCAGGCATTTTGGGGTGACTCAGTAAATGGTAGATCTTGCTAC CAGTGGAACAGCCACTAAGGATTCTGCAGTGAGAGCAGAGGGCCAGCTAAGTGGTACTCTCCCAGAGACTGTCTGACTCACGCCACCCCCTCCACCTTGG ACACAGGACGCTGTGGTTTCTGAGCCAGGTACAATGACTCCTTTCGCAGCCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGG GCCCTGTCTCCTCAGCTTCAGGCACCACCACTGACCTGGGACAGTGAATCGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGT GCTGCCTGGTCCCTGTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTTCAACAA GATCACCCCCAACCTGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGAGCATCGCT ACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCTCAGA TCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCAATGGCCTGTTCCTCAGCGAGGGCCTGAA GCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAAGAGGCCAAGAAACAGATCAAC GATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGCTTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAG GCAAATGGGAGAGACCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTGAAGGTGCCTATGATGAAGCGTTTAGG CATGTTTAACATCCAGCACTGTAAGAAGCTGTCCAGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGATGAGGGG AAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTGGAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGT CCATTACTGGAACCTATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCTGACCTCTCCGGGGTCACAGAGGAGGC ACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCTGTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATACCCATG TCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAACAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGTGAATCCCA CCCAAAAATAACTGCCTCTCGCTCCTCAACCCCTCCCCTCCATCCCTGGCCCCCTCCCTGGATGACATTAAAGAAGGGTTGAGCTGGTCCCTGCCTGCA

refseq_SERPINA1.F1 (forward primer)
refseq_SERPINA1.R1 (reverse primer)
Multiple exon skipping

Frame 0

WAGTGHCAQGMHCLHAATLRVLS*TKKEEGVGP PRKA*PLLLPGIPGWRGGNLLPAFRPLSCACQKR QSLRRA*GEQERAAVSLQHQAFWGDSVNGRSCY QWNSH*GFCSESRGPAKWYSPRDCLTHATPSTL DTGRCGF*ARYNDSFRSLPRCPSGSTA*IRTRTG PCLLSFRHHH*PGTVNRQCRLLSRGASSCWQAC AAWSLSPWLRIPREMLPRRQIHPTMIRITQPST RSPPTWLSSPSAYTASWHTSPTAPISSSPQ*ASL QPLQCSPWGPRLTLTMKSWRA*ISTSRRFRRLR SMKASRNSSVPSTSQTASSS*PPAMACSSARA* S*WISFWRMLKSCTTQKPSLSTSGTPKRPRNRST ITWRRVLKGKLWIWSRSLTETQFLLW*ITSSLK ANGRDPLKSRTPRKRTSTWTR*PP*RCL**SV* ACLTSSTVRSCPAGCC**NTWAMPPPSSSCLMRG NYSTWKMNSPTISSPSSWKMKTEGLPAYIYPNC PLLEPMI*RASWVNWASLRSSAMGLTSPGSQRR HP*SSPRPCIRLC*PSTRKGLKLLGPCF*RPYPC LSPPRSSSTNPLSS**LNKIPSLPSSWEKW*IP PKNNCLSLLNPSPPSLAPSLDDIKEGLSWSLPA

Frame 1

GQELGTVPRACTASTQQPSES*AEPRRRRGSGL RGRPSRCCCQEFQVGGAATSCQPSGHSPVPARR DRA*GELEESRKGRQ*VFSIRHFGVTQ*MVDLAT SGTATKDSAVRAEGQLSGTLPETV*LTPPPPPW TQDAVVSEPGTMTPFAASPVAPLDPLLKYGRGQ GPVSSASGTTTDLGQ*IDNAVFCLVGHPPAGRPV LPGPCLPG*GSPGRCCPEDRYIPP*SGSPNLQQ DHPQPG*VRLQPIPPAGTPVQQHQYLLLPSEHR YSLCNALPGDQG*HSR*NPGGPEFQPHGDSGGSD P*RLPGTPPYPQPARQPAPADHRQWPVPQRGPE ASG*VFGGC*KVVPLRSLHCQLRGHRRGQETDQ RLRGEGYSRENCGFGQGA*QRHSFCSGELHLL*R QMGETL*SQGHRGRGLPRGPGDHREGAYDEAFR HV*HPAL*EAVQLGAADEIPGQCHRHLLPA**G ETTAPGK*THPRYHHQVPGK*RQKVCQLTFTQTV HYWNL*SEERPGSTGHH*GLQQWG*PLRGHRGG TPEALQGRA*GCADHRRERD*SCWGHVFRGHTH VYPPRGQVQQTLCLLND*TKYQVSPLHGKSGESH PKITASRSSTPPLHPWPPPWMTLKKG*AGPCL

Frame 2

GRNWALCPGHALPPRSNPQSPELNQEGGGGRAS EEGLAAAAARNSRLEGRQPPASLQATLLCLPEE TELEESLRRAGKGGSKSSASGILG*LSKW*ILL PVEQPLRILQ*EQRAS*VVLSQRLSDSRHPLHLG HRTLWFLSQVQ*LLSQPPPLPLWIHCLNTDEDR ALSPQLQAPPLTWDSESTMPSSVSWGILLLAGL CCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNK ITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIA TAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQ IHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLK LVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQIN DYVEKGTQGKIVDLVKELDRDTVFALVNYIFFK GKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLG MFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEG KLQHLENELTHDIITKFLENEDRRSASLHLPKL SITGTYDLKSVLGQLGITKVFSNGADLSGVTEEA PLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM SIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP TQK*LPLAPQPLPSIPGPLPG*H*RRVELVPAC