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Sequences

Sequence NM_213648

CCTCCAGGTCCTTCCCCTAAAACTTGGCACTGCCGATACTCCCAGCCCGTTCCTTCCCAAGTCAGGAACTTGCAGGGGACCCCTTGGCAATTCTTTTTCT CTCAAGAGCAGACAGCCTTCAGTCCCAGCCGCTGCCAGGGCTGGTGTGTCTGACCCAGCTGTGGTTTTTCCAGGCCTGAAGGCCCCGGAGTGCACCAGCG GCATGTACAAAGAGACCGTCTACTCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTCGGGAGCAGGGCAGCACCCCCAGCCGCAGCCCCCGCTGCA CAAGGCCAATCAGCCCCCCCACGGTGTCCCCCAACTCTCTCTCTACGAACATTTCAACAGCCCACATCCCACCCCTGCACCTGCGGACATCAGCCAGAAG CAAGTTCACAGGCCTCTGCAGACCCCTGACCTCTCTGGCTTCTACTCCCTGACCTCAGGCAGCATGGGGCAGCTCCCCCACACTGTGAGCTGGTTCACCC ACCCATCCTTGATGCTAGGTTCTGGTGTACCTGGTCACCCAGCAGCCATCCCCCACCCGGCCATTGTGCCCCCCTCAGGGAAGCAGGAGCTGCAGCCCTT CGACCGCAACCTGAAGACACAAGCAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACCATCAAGAAGCCCCTCAATGCCTTCATGCTGTACATGAAG GAGATGAGAGCCAAGGTCATTGCAGAGTGCACACTTAAGGAGAGCGCTGCCATCAACCAGATCCTGGGCCGCAGGTGGCACGCGCTGTCGCGAGAAGAGC AGGCCAAGTACTATGAGCTGGCCCGCAAGGAGAGGCAGCTGCACATGCAGCTATACCCAGGCTGGTCAGCGCGGGACAACTACGGGAAGAAGAAGAGGCG GTCGAGGGAAAAGCACCAAGAATCCACCACAGGAGGAAAAAGAAATGCATTCGGTACTTACCCGGAGAAGGCCGCTGCCCCAGCCCCGTTCCTTCCGATG ACAGTGCTCTAGGCTGCCCCGGGTCCCCAGCTCCCCAGGACTCACCCTCATACCATCTGCTGCCCCGCTTCCCCACAGAACTGCTTACTAGCCCTGCGGA GCCGGCACCTACATCCCCAGGTCTCTCCACTGCTCTCAGCCTCCCAACCCCAGGGCCCCCACAGGCCCCCCGCAGCACCCTGCAGAGCACACAGGTACAG CAACAGGAATCTCAGAGACAGGTGGCCTAGCAGGCACAGGACACCTGGCCGCCTCCAGGAGCCTACCCCCTGAAAGTGACAGAGACCCAGATCTCATGGA AACTGGCCAGGGGTCCTGTTAACGTCATCTCAGGGTCCAGACCCTGAAGATTTCAGAGGCTGCAGGACTTCTGCCTGAACCTGGGGTCATCGATTCAAAC TGCTCCAAGTGGTGGGAATCAGATCTGTCTTGATGTGTCATCTAATTAAGGGAATCCCTTGTACCTATGGCTGCCTGCATCTATTCTTTGTACCATCTGT CTTGCCAGCCAGAAGCCTCTGCCTCCCTAGCTTTTCTGCTATAGGTCAGAGATGGGCTGAACTGAGCCTAGCTACCTTCTCTACCCATCTCCCCCATCCC CCACTGCCACACCCTCCCCATTCAGACACTTCATGGACCAAGAATGAGCTGGTTTGTCAAACAACATGTGAGCATGGTCACAAGCACAAAGCTCAAGATG ACAGCTCTTCTAAGGAAATGGAGAAGCTCTGTTTATAAAAACAAAAACAAAACCAGCTGCTACTCATAAGTTGGACCAGAGGAAGCCCCTTACTATGATC TCAGGAGCTTGCAAGAAGCAGGAAGGGGAATGGAATAGGTTAAGTTTAGGCCTATCAACCTAAGCAACAGAAATAATCTGACACTACCTTATCAGGCAAA TTGGGGAGGGGAGGGTGTATCTAGCTCTAGTTCAAATTATTTGGAAGTGTTCCCTGAGAAACCCACCAGCCTAAGAAGCTCTGGCCCCAGGCTTGTCACT AGCAGCTGCAGTCAACAGTTCAAAGAAGTCATGGCCCAAATCCAGTGTGCACCCCTCCCCATTCACAGAGCCTTTTTCACAATTCCATTTCCAGTTCATC TATGGCAGTCCAGCCAGCTCCTGGGCAGCTTGAGAGGGCAAACCCAAAACCTCATGACAGCCAGAGCCTGTCTTTCAGCATTCAGTCCGCCTGGCCGGCT CCAGTTTCCCCATGGGGCTGCGGGACAGAGGACCATTACAACTAGATCAAGGAGCCCAGAAAACCTCCAGTAGTGGACAACAGGTTTTCACCATAGCCTA CGTTAACCCATTTTTGAGCCAAGCTTCAACCCTCAGCCTTGAAAAACAAGTCTTTAATTTAATTTTTGTTTTTTGCCTAAATCCAAAGAAAAAGGGCTGC CGGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGCAGGCCGAGGCAGGTGGATCACCTGACGTCAGTAGTTTGAGACCAGCCTGGCCAAC ATGGTGAAACCCTGTATCTACTAAAAATACAAAAATTAGCCGGACGTGGTGGTGCGCGCATGTAATCCCAGCTACTCGGGAGGCTGAGGCGGAAGAATCA CTTGAACCCGGGAGGCGGAGGTTCCAGTGAGCCGAGATGGCGCTATTGCACTCCAGTCTGGGTAACAGGGAGACTGCATCTCAAAAAAAAAAAAAAAAAA AAAAAAGGGCTGTCCATGTATTCACACACCCCTCAAAAAAAGCCTTTAGTTCCTACTTTAGCCACTGGTTTCTCAGAATCCAAAGATCACATATTCTAGT GTAACACTGCAAGAAGTCTTGAGAAAAAGATTATTGTAGTGTTCAAAATATTTTTGTATTGTTAATGCATCATCATAGAAAAACTTTTAAACATGAGAAT AAAGATACTTTTTACTGGGTTTGTTTTTCAAAGCCTGA

refseq_TCF7.F1 (forward primer)
refseq_TCF7.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

PPGPSPKTWHCRYSQPVPSQVRNLQGTPWQFFF SQEQTAFSPSRCQGWCV*PSCGFSRPEGPGVHQR HVQRDRLLRLQSAHALPTPLGSRAAPPAAAPAA QGQSAPPRCPPTLSLRTFQQPTSHPCTCGHQPE ASSQASADP*PLWLLLPDLRQHGAAPPHCELVHP PILDARFWCTWSPSSHPPPGHCAPLREAGAAAL RPQPEDTSRVQGREGGQEANHQEAPQCLHAVHE GDESQGHCRVHT*GERCHQPDPGPQVARAVARRA GQVL*AGPQGEAAAHAAIPRLVSAGQLREEEEA VEGKAPRIHHRRKKKCIRYLPGEGRCPSPVPSD DSALGCPGSPAPQDSPSYHLLPRFPTELLTSPAE PAPTSPGLSTALSLPTPGPPQAPRSTLQSTQVQ QQESQRQVA*QAQDTWPPPGAYPLKVTETQISW KLARGPVNVISGSRP*RFQRLQDFCLNLGSSIQT APSGGNQICLDVSSN*GNPLYLWLPASILCTIC LASQKPLPP*LFCYRSEMG*TEPSYLLYPSPPS PTATPSPFRHFMDQE*AGLSNNM*AWSQAQSSR* QLF*GNGEALFIKTKTKPAATHKLDQRKPLTMI SGACKKQEGEWNRLSLGLST*ATEII*HYLIRQ IGEGRVYLALVQIIWKCSLRNPPA*EALAPGLSL AAAVNSSKKSWPKSSVHPSPFTEPFSQFHFQFI YGSPASSWAA*EGKPKTS*QPEPVFQHSVRLAG SSFPMGLRDRGPLQLDQGAQKTSSSGQQVFTIAY VNPFLSQASTLSLEKQVFNLIFVFCLNPKKKGC RARRGGSRL*SQHFGRPRQVDHLTSVV*DQPGQ HGETLYLLKIQKLAGRGGARM*SQLLGRLRRKNH LNPGGGGSSEPRWRYCTPVWVTGRLHLKKKKKK KKGLSMYSHTPQKKPLVPTLATGFSESKDHIF* CNTARSLEKKIIVVFKIFLYC*CIIIEKLLNMRI KILFTGFVFQSL

Frame 1

LQVLPLKLGTADTPSPFLPKSGTCRGPLGNSFS LKSRQPSVPAAARAGVSDPAVVFPGLKAPECTS GMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLH KANQPPHGVPQLSLYEHFNSPHPTPAPADISQK QVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFT HPSLMLGSGVPGHPAAIPHPAIVPPSGKQELQPF DRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMK EMRAKVIAECTLKESAAINQILGRRWHALSREE QAKYYELARKERQLHMQLYPGWSARDNYGKKKRR SREKHQESTTGGKRNAFGTYPEKAAAPAPFLPM TVL*AAPGPQLPRTHPHTICCPASPQNCLLALR SRHLHPQVSPLLSASQPQGPHRPPAAPCRAHRYS NRNLRDRWPSRHRTPGRLQEPTP*K*QRPRSHG NWPGVLLTSSQGPDPEDFRGCRTSA*TWGHRFK LLQVVGIRSVLMCHLIKGIPCTYGCLHLFFVPSV LPARSLCLPSFSAIGQRWAELSLATFSTHLPHP PLPHPPHSDTSWTKNELVCQTTCEHGHKHKAQD DSSSKEMEKLCL*KQKQNQLLLISWTRGSPLL*S QELARSRKGNGIG*V*AYQPKQQK*SDTTLSGK LGRGGCI*L*FKLFGSVP*ETHQPKKLWPQACH *QLQSTVQRSHGPNPVCTPPHSQSLFHNSISSSS MAVQPAPGQLERANPKPHDSQSLSFSIQSAWPA PVSPWGCGTEDHYN*IKEPRKPPVVDNRFSP*P TLTHF*AKLQPSALKNKSLI*FLFFA*IQRKRAA GPGAVAHACNPSTLAGRGRWIT*RQ*FETSLAN MVKPCIY*KYKN*PDVVVRACNPSYSGG*GGRI T*TREAEVPVSRDGAIALQSG*QGDCISKKKKKK KKGCPCIHTPLKKSL*FLL*PLVSQNPKITYSS VTLQEVLRKRLL*CSKYFCIVNASS*KNF*T*E *RYFLLGLFFKA*

Frame 2

SRSFP*NLALPILPARSFPSQELAGDPLAILFL SRADSLQSQPLPGLVCLTQLWFFQA*RPRSAPA ACTKRPSTPPSICSCITHPPREQGSTPSRSPRC TRPISPPTVSPNSLSTNISTAHIPPLHLRTSARS KFTGLCRPLTSLASTP*PQAAWGSSPTL*AGSP THP*C*VLVYLVTQQPSPTRPLCPPQGSRSCSP STAT*RHKQSPRQRRRPRSQPSRSPSMPSCCT*R R*EPRSLQSAHLRRALPSTRSWAAGGTRCREKS RPSTMSWPARRGSCTCSYTQAGQRGTTTGRRRG GRGKSTKNPPQEEKEMHSVLTRRRPLPQPRSFR* QCSRLPRVPSSPGLTLIPSAAPLPHRTAY*PCG AGTYIPRSLHCSQPPNPRAPTGPPQHPAEHTGT ATGISETGGLAGTGHLAASRSLPPESDRDPDLME TGQGSC*RHLRVQTLKISEAAGLLPEPGVIDSN CSKWWESDLS*CVI*LRESLVPMAACIYSLYHL SCQPEASASLAFLL*VRDGLN*A*LPSLPISPIP HCHTLPIQTLHGPRMSWFVKQHVSMVTSTKLKM TALLRKWRSSVYKNKNKTSCYS*VGPEEAPYYD LRSLQEAGRGME*VKFRPINLSNRNNLTLPYQAN WGGEGVSSSSSNYLEVFPEKPTSLRSSGPRLVT SSCSQQFKEVMAQIQCAPLPIHRAFFTIPFPVH LWQSSQLLGSLRGQTQNLMTARACLSAFSPPGRL QFPHGAAGQRTITTRSRSPENLQ*WTTGFHHSL R*PIFEPSFNPQP*KTSL*FNFCFLPKSKEKGL PGQARWLTPVIPALWQAEAGGSPDVSSLRPAWPT W*NPVSTKNTKISRTWWCAHVIPATREAEAEES LEPGRRRFQ*AEMALLHSSLGNRETASQKKKKK KKRAVHVFTHPSKKAFSSYFSHWFLRIQRSHILV *HCKKS*EKDYCSVQNIFVLLMHHHRKTFKHEN KDTFYWVCFSKP

Sequence NM_201632

GCCCAGGTGACTGACTAATCCGCCGCCTTCAGGAGACAGAATTGGCCAAGGCCTGAAGGCCCCGGAGTGCACCAGCGGCATGTACAAAGAGACCGTCTAC TCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTCGGGAGCAGGGCAGCACCCCCAGCCGCAGCCCCCGCTGCACAAGGCCAATCAGCCCCCCCACG GTGTCCCCCAACTCTCTCTCTACGAACATTTCAACAGCCCACATCCCACCCCTGCACCTGCGGACATCAGCCAGAAGCAAGTTCACAGGCCTCTGCAGAC CCCTGACCTCTCTGGCTTCTACTCCCTGACCTCAGGCAGCATGGGGCAGCTCCCCCACACTGTGAGCTGGTTCACCCACCCATCCTTGATGCTAGGTTCT GGTGTACCTGGTCACCCAGCAGCCATCCCCCACCCGGCCATTGTGCCCCCCTCAGGGAAGCAGGAGCTGCAGCCCTTCGACCGCAACCTGAAGACACAAG CAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACCATCAAGAAGCCCCTCAATGCCTTCATGCTGTACATGAAGGAGATGAGAGCCAAGGTCATTGC AGAGTGCACACTTAAGGAGAGCGCTGCCATCAACCAGATCCTGGGCCGCAGGTGGCACGCGCTGTCGCGAGAAGAGCAGGCCAAGTACTATGAGCTGGCC CGCAAGGAGAGGCAGCTGCACATGCAGCTATACCCAGGCTGGTCAGCGCGGGACAACTACGGGAAGAAGAAGAGGCGGTCGAGGGAAAAGCACCAAGAAT CCACCACAGGAGGAAAAAGAAATGCATTCGGTACTTACCCGGAGAAGGCCGCTGCCCCAGCCCCGTTCCTTCCGATGACAGTGCTCTAGGCTGCCCCGGG TCCCCAGCTCCCCAGGACTCACCCTCATACCATCTGCTGCCCCGCTTCCCCACAGAACTGCTTACTAGCCCTGCGGAGCCGGCACCTACATCCCCAGGTC TCTCCACTGCTCTCAGCCTCCCAACCCCAGGGCCCCCACAGGCCCCCCGCAGCACCCTGCAGAGCACACAGGTACAGCAACAGGAATCTCAGAGACAGGT GGCCTAGCAGGCACAGGACACCTGGCCGCCTCCAGGAGCCTACCCCCTGAAAGTGACAGAGACCCAGATCTCATGGAAACTGGCCAGGGGTCCTGTTAAC GTCATCTCAGGGTCCAGACCCTGAAGATTTCAGAGGCTGCAGGACTTCTGCCTGAACCTGGGGTCATCGATTCAAACTGCTCCAAGTGGTGGGAATCAGA TCTGTCTTGATGTGTCATCTAATTAAGGGAATCCCTTGTACCTATGGCTGCCTGCATCTATTCTTTGTACCATCTGTCTTGCCAGCCAGAAGCCTCTGCC TCCCTAGCTTTTCTGCTATAGGTCAGAGATGGGCTGAACTGAGCCTAGCTACCTTCTCTACCCATCTCCCCCATCCCCCACTGCCACACCCTCCCCATTC AGACACTTCATGGACCAAGAATGAGCTGGTTTGTCAAACAACATGTGAGCATGGTCACAAGCACAAAGCTCAAGATGACAGCTCTTCTAAGGAAATGGAG AAGCTCTGTTTATAAAAACAAAAACAAAACCAGCTGCTACTCATAAGTTGGACCAGAGGAAGCCCCTTACTATGATCTCAGGAGCTTGCAAGAAGCAGGA AGGGGAATGGAATAGGTTAAGTTTAGGCCTATCAACCTAAGCAACAGAAATAATCTGACACTACCTTATCAGGCAAATTGGGGAGGGGAGGGTGTATCTA GCTCTAGTTCAAATTATTTGGAAGTGTTCCCTGAGAAACCCACCAGCCTAAGAAGCTCTGGCCCCAGGCTTGTCACTAGCAGCTGCAGTCAACAGTTCAA AGAAGTCATGGCCCAAATCCAGTGTGCACCCCTCCCCATTCACAGAGCCTTTTTCACAATTCCATTTCCAGTTCATCTATGGCAGTCCAGCCAGCTCCTG GGCAGCTTGAGAGGGCAAACCCAAAACCTCATGACAGCCAGAGCCTGTCTTTCAGCATTCAGTCCGCCTGGCCGGCTCCAGTTTCCCCATGGGGCTGCGG GACAGAGGACCATTACAACTAGATCAAGGAGCCCAGAAAACCTCCAGTAGTGGACAACAGGTTTTCACCATAGCCTACGTTAACCCATTTTTGAGCCAAG CTTCAACCCTCAGCCTTGAAAAACAAGTCTTTAATTTAATTTTTGTTTTTTGCCTAAATCCAAAGAAAAAGGGCTGCCGGGCCAGGCGCGGTGGCTCACG CCTGTAATCCCAGCACTTTGGCAGGCCGAGGCAGGTGGATCACCTGACGTCAGTAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTATCTACTA AAAATACAAAAATTAGCCGGACGTGGTGGTGCGCGCATGTAATCCCAGCTACTCGGGAGGCTGAGGCGGAAGAATCACTTGAACCCGGGAGGCGGAGGTT CCAGTGAGCCGAGATGGCGCTATTGCACTCCAGTCTGGGTAACAGGGAGACTGCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGGGCTGTCCATGTATTC ACACACCCCTCAAAAAAAGCCTTTAGTTCCTACTTTAGCCACTGGTTTCTCAGAATCCAAAGATCACATATTCTAGTGTAACACTGCAAGAAGTCTTGAG AAAAAGATTATTGTAGTGTTCAAAATATTTTTGTATTGTTAATGCATCATCATAGAAAAACTTTTAAACATGAGAATAAAGATACTTTTTACTGGGTTTG TTTTTCAAAGCCTGA

refseq_TCF7.F1 (forward primer)
refseq_TCF7.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

AQVTD*SAAFRRQNWPRPEGPGVHQRHVQRDRL LRLQSAHALPTPLGSRAAPPAAAPAAQGQSAPPR CPPTLSLRTFQQPTSHPCTCGHQPEASSQASAD P*PLWLLLPDLRQHGAAPPHCELVHPPILDARF WCTWSPSSHPPPGHCAPLREAGAAALRPQPEDTS RVQGREGGQEANHQEAPQCLHAVHEGDESQGHC RVHT*GERCHQPDPGPQVARAVARRAGQVL*AG PQGEAAAHAAIPRLVSAGQLREEEEAVEGKAPRI HHRRKKKCIRYLPGEGRCPSPVPSDDSALGCPG SPAPQDSPSYHLLPRFPTELLTSPAEPAPTSPG LSTALSLPTPGPPQAPRSTLQSTQVQQQESQRQV A*QAQDTWPPPGAYPLKVTETQISWKLARGPVN VISGSRP*RFQRLQDFCLNLGSSIQTAPSGGNQ ICLDVSSN*GNPLYLWLPASILCTICLASQKPLP P*LFCYRSEMG*TEPSYLLYPSPPSPTATPSPF RHFMDQE*AGLSNNM*AWSQAQSSR*QLF*GNG EALFIKTKTKPAATHKLDQRKPLTMISGACKKQE GEWNRLSLGLST*ATEII*HYLIRQIGEGRVYL ALVQIIWKCSLRNPPA*EALAPGLSLAAAVNSS KKSWPKSSVHPSPFTEPFSQFHFQFIYGSPASSW AA*EGKPKTS*QPEPVFQHSVRLAGSSFPMGLR DRGPLQLDQGAQKTSSSGQQVFTIAYVNPFLSQ ASTLSLEKQVFNLIFVFCLNPKKKGCRARRGGSR L*SQHFGRPRQVDHLTSVV*DQPGQHGETLYLL KIQKLAGRGGARM*SQLLGRLRRKNHLNPGGGG SSEPRWRYCTPVWVTGRLHLKKKKKKKKGLSMYS HTPQKKPLVPTLATGFSESKDHIF*CNTARSLE KKIIVVFKIFLYC*CIIIEKLLNMRIKILFTGF VFQSL

Frame 1

PR*LTNPPPSGDRIGQGLKAPECTSGMYKETVY SAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPH GVPQLSLYEHFNSPHPTPAPADISQKQVHRPLQT PDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGS GVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQ AESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIA ECTLKESAAINQILGRRWHALSREEQAKYYELA RKERQLHMQLYPGWSARDNYGKKKRRSREKHQE STTGGKRNAFGTYPEKAAAPAPFLPMTVL*AAPG PQLPRTHPHTICCPASPQNCLLALRSRHLHPQV SPLLSASQPQGPHRPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP*K*QRPRSHGNWPGVLLT SSQGPDPEDFRGCRTSA*TWGHRFKLLQVVGIR SVLMCHLIKGIPCTYGCLHLFFVPSVLPARSLC LPSFSAIGQRWAELSLATFSTHLPHPPLPHPPHS DTSWTKNELVCQTTCEHGHKHKAQDDSSSKEME KLCL*KQKQNQLLLISWTRGSPLL*SQELARSR KGNGIG*V*AYQPKQQK*SDTTLSGKLGRGGCI* L*FKLFGSVP*ETHQPKKLWPQACH*QLQSTVQ RSHGPNPVCTPPHSQSLFHNSISSSSMAVQPAP GQLERANPKPHDSQSLSFSIQSAWPAPVSPWGCG TEDHYN*IKEPRKPPVVDNRFSP*PTLTHF*AK LQPSALKNKSLI*FLFFA*IQRKRAAGPGAVAH ACNPSTLAGRGRWIT*RQ*FETSLANMVKPCIY* KYKN*PDVVVRACNPSYSGG*GGRIT*TREAEV PVSRDGAIALQSG*QGDCISKKKKKKKKGCPCI HTPLKKSL*FLL*PLVSQNPKITYSSVTLQEVLR KRLL*CSKYFCIVNASS*KNF*T*E*RYFLLGL FFKA*

Frame 2

PGD*LIRRLQETELAKA*RPRSAPAACTKRPST PPSICSCITHPPREQGSTPSRSPRCTRPISPPT VSPNSLSTNISTAHIPPLHLRTSARSKFTGLCR PLTSLASTP*PQAAWGSSPTL*AGSPTHP*C*VL VYLVTQQPSPTRPLCPPQGSRSCSPSTAT*RHK QSPRQRRRPRSQPSRSPSMPSCCT*RR*EPRSL QSAHLRRALPSTRSWAAGGTRCREKSRPSTMSWP ARRGSCTCSYTQAGQRGTTTGRRRGGRGKSTKN PPQEEKEMHSVLTRRRPLPQPRSFR*QCSRLPR VPSSPGLTLIPSAAPLPHRTAY*PCGAGTYIPRS LHCSQPPNPRAPTGPPQHPAEHTGTATGISETG GLAGTGHLAASRSLPPESDRDPDLMETGQGSC* RHLRVQTLKISEAAGLLPEPGVIDSNCSKWWESD LS*CVI*LRESLVPMAACIYSLYHLSCQPEASA SLAFLL*VRDGLN*A*LPSLPISPIPHCHTLPI QTLHGPRMSWFVKQHVSMVTSTKLKMTALLRKWR SSVYKNKNKTSCYS*VGPEEAPYYDLRSLQEAG RGME*VKFRPINLSNRNNLTLPYQANWGGEGVS SSSSNYLEVFPEKPTSLRSSGPRLVTSSCSQQFK EVMAQIQCAPLPIHRAFFTIPFPVHLWQSSQLL GSLRGQTQNLMTARACLSAFSPPGRLQFPHGAA GQRTITTRSRSPENLQ*WTTGFHHSLR*PIFEPS FNPQP*KTSL*FNFCFLPKSKEKGLPGQARWLT PVIPALWQAEAGGSPDVSSLRPAWPTW*NPVST KNTKISRTWWCAHVIPATREAEAEESLEPGRRRF Q*AEMALLHSSLGNRETASQKKKKKKKRAVHVF THPSKKAFSSYFSHWFLRIQRSHILV*HCKKS* EKDYCSVQNIFVLLMHHHRKTFKHENKDTFYWVC FSKP

Sequence NM_003202

CCCGCCAGCTCGCGGAGCCGCTCTGCCCCGCGCCCTAGCCCGCGCCTGCAGCCCGCCCAGGCGGAGTCAGCCCGCGCTCCGCCCGCCGCGATCCGAGCTC GGAGGTTCGGACTCCGGGCTCGCCGCCCCCCGGGCCGGCTCCGCGCCCCGCACTCCCGGCGCCCAGCGCCCCGCGCCCCGGCGGGCGGAGCGCACCATGC CGCAGCTGGACTCCGGCGGGGGCGGCGCGGGCGGCGGCGACGACCTCGGCGCGCCGGACGAGCTGCTGGCCTTCCAGGATGAAGGCGAGGAGCAGGACGA CAAGAGCCGCGACAGCGCCGCCGGTCCCGAGCGCGACCTGGCCGAGCTCAAGTCGTCGCTCGTGAACGAGTCCGAGGGCGCGGCCGGCGGCGCAGGGATC CCGGGGGTCCCGGGGGCCGGCGCCGGGGCCCGCGGCGAGGCCGAGGCTCTCGGGCGGGAACACGCTGCGCAGAGACTCTTCCCGGACAAACTTCCAGAGC CCCTGGAGGACGGCCTGAAGGCCCCGGAGTGCACCAGCGGCATGTACAAAGAGACCGTCTACTCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTC GGGAGCAGGGCAGCACCCCCAGCCGCAGCCCCCGCTGCACAAGGCCAATCAGCCCCCCCACGGTGTCCCCCAACTCTCTCTCTACGAACATTTCAACAGC CCACATCCCACCCCTGCACCTGCGGACATCAGCCAGAAGCAAGTTCACAGGCCTCTGCAGACCCCTGACCTCTCTGGCTTCTACTCCCTGACCTCAGGCA GCATGGGGCAGCTCCCCCACACTGTGAGCTGGTTCACCCACCCATCCTTGATGCTAGGTTCTGGTGTACCTGGTCACCCAGCAGCCATCCCCCACCCGGC CATTGTGCCCCCCTCAGGGAAGCAGGAGCTGCAGCCCTTCGACCGCAACCTGAAGACACAAGCAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACC ATCAAGAAGCCCCTCAATGCCTTCATGCTGTACATGAAGGAGATGAGAGCCAAGGTCATTGCAGAGTGCACACTTAAGGAGAGCGCTGCCATCAACCAGA TCCTGGGCCGCAGGTGGCACGCGCTGTCGCGAGAAGAGCAGGCCAAGTACTATGAGCTGGCCCGCAAGGAGAGGCAGCTGCACATGCAGCTATACCCAGG CTGGTCAGCGCGGGACAACTACGGGAAGAAGAAGAGGCGGTCGAGGGAAAAGCACCAAGAATCCACCACAGGAGGAAAAAGAAATGCATTCGGTACTTAC CCGGAGAAGGCCGCTGCCCCAGCCCCGTTCCTTCCGATGACAGTGCTCTAGGCTGCCCCGGGTCCCCAGCTCCCCAGGACTCACCCTCATACCATCTGCT GCCCCGCTTCCCCACAGAACTGCTTACTAGCCCTGCGGAGCCGGCACCTACATCCCCAGGTCTCTCCACTGCTCTCAGCCTCCCAACCCCAGGGCCCCCA CAGGCCCCCCGCAGCACCCTGCAGAGCACACAGGTACAGCAACAGGAATCTCAGAGACAGGTGGCCTAGCAGGCACAGGACACCTGGCCGCCTCCAGGAG CCTACCCCCTGAAAGTGACAGAGACCCAGATCTCATGGAAACTGGCCAGGGGTCCTGTTAACGTCATCTCAGGGTCCAGACCCTGAAGATTTCAGAGGCT GCAGGACTTCTGCCTGAACCTGGGGTCATCGATTCAAACTGCTCCAAGTGGTGGGAATCAGATCTGTCTTGATGTGTCATCTAATTAAGGGAATCCCTTG TACCTATGGCTGCCTGCATCTATTCTTTGTACCATCTGTCTTGCCAGCCAGAAGCCTCTGCCTCCCTAGCTTTTCTGCTATAGGTCAGAGATGGGCTGAA CTGAGCCTAGCTACCTTCTCTACCCATCTCCCCCATCCCCCACTGCCACACCCTCCCCATTCAGACACTTCATGGACCAAGAATGAGCTGGTTTGTCAAA CAACATGTGAGCATGGTCACAAGCACAAAGCTCAAGATGACAGCTCTTCTAAGGAAATGGAGAAGCTCTGTTTATAAAAACAAAAACAAAACCAGCTGCT ACTCATAAGTTGGACCAGAGGAAGCCCCTTACTATGATCTCAGGAGCTTGCAAGAAGCAGGAAGGGGAATGGAATAGGTTAAGTTTAGGCCTATCAACCT AAGCAACAGAAATAATCTGACACTACCTTATCAGGCAAATTGGGGAGGGGAGGGTGTATCTAGCTCTAGTTCAAATTATTTGGAAGTGTTCCCTGAGAAA CCCACCAGCCTAAGAAGCTCTGGCCCCAGGCTTGTCACTAGCAGCTGCAGTCAACAGTTCAAAGAAGTCATGGCCCAAATCCAGTGTGCACCCCTCCCCA TTCACAGAGCCTTTTTCACAATTCCATTTCCAGTTCATCTATGGCAGTCCAGCCAGCTCCTGGGCAGCTTGAGAGGGCAAACCCAAAACCTCATGACAGC CAGAGCCTGTCTTTCAGCATTCAGTCCGCCTGGCCGGCTCCAGTTTCCCCATGGGGCTGCGGGACAGAGGACCATTACAACTAGATCAAGGAGCCCAGAA AACCTCCAGTAGTGGACAACAGGTTTTCACCATAGCCTACGTTAACCCATTTTTGAGCCAAGCTTCAACCCTCAGCCTTGAAAAACAAGTCTTTAATTTA ATTTTTGTTTTTTGCCTAAATCCAAAGAAAAAGGGCTGCCGGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGCAGGCCGAGGCAGGTGG ATCACCTGACGTCAGTAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTATCTACTAAAAATACAAAAATTAGCCGGACGTGGTGGTGCGCGCAT GTAATCCCAGCTACTCGGGAGGCTGAGGCGGAAGAATCACTTGAACCCGGGAGGCGGAGGTTCCAGTGAGCCGAGATGGCGCTATTGCACTCCAGTCTGG GTAACAGGGAGACTGCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGGGCTGTCCATGTATTCACACACCCCTCAAAAAAAGCCTTTAGTTCCTACTTTAG CCACTGGTTTCTCAGAATCCAAAGATCACATATTCTAGTGTAACACTGCAAGAAGTCTTGAGAAAAAGATTATTGTAGTGTTCAAAATATTTTTGTATTG TTAATGCATCATCATAGAAAAACTTTTAAACATGAGAATAAAGATACTTTTTACTGGGTTTGTTTTTCAAAGCCTGA

refseq_TCF7.F1 (forward primer)
refseq_TCF7.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

PASSRSRSAPRPSPRLQPAQAESARAPPAAIRA RRFGLRARRPPGRLRAPHSRRPAPRAPAGGAHHA AAGLRRGRRGRRRRPRRAGRAAGLPG*RRGAGR QEPRQRRRSRARPGRAQVVARERVRGRGRRRRD PGGPGGRRRGPRRGRGSRAGTRCAETLPGQTSRA PGGRPEGPGVHQRHVQRDRLLRLQSAHALPTPL GSRAAPPAAAPAAQGQSAPPRCPPTLSLRTFQQ PTSHPCTCGHQPEASSQASADP*PLWLLLPDLRQ HGAAPPHCELVHPPILDARFWCTWSPSSHPPPG HCAPLREAGAAALRPQPEDTSRVQGREGGQEAN HQEAPQCLHAVHEGDESQGHCRVHT*GERCHQPD PGPQVARAVARRAGQVL*AGPQGEAAAHAAIPR LVSAGQLREEEEAVEGKAPRIHHRRKKKCIRYL PGEGRCPSPVPSDDSALGCPGSPAPQDSPSYHLL PRFPTELLTSPAEPAPTSPGLSTALSLPTPGPP QAPRSTLQSTQVQQQESQRQVA*QAQDTWPPPG AYPLKVTETQISWKLARGPVNVISGSRP*RFQRL QDFCLNLGSSIQTAPSGGNQICLDVSSN*GNPL YLWLPASILCTICLASQKPLPP*LFCYRSEMG* TEPSYLLYPSPPSPTATPSPFRHFMDQE*AGLSN NM*AWSQAQSSR*QLF*GNGEALFIKTKTKPAA THKLDQRKPLTMISGACKKQEGEWNRLSLGLST *ATEII*HYLIRQIGEGRVYLALVQIIWKCSLRN PPA*EALAPGLSLAAAVNSSKKSWPKSSVHPSP FTEPFSQFHFQFIYGSPASSWAA*EGKPKTS*Q PEPVFQHSVRLAGSSFPMGLRDRGPLQLDQGAQK TSSSGQQVFTIAYVNPFLSQASTLSLEKQVFNL IFVFCLNPKKKGCRARRGGSRL*SQHFGRPRQV DHLTSVV*DQPGQHGETLYLLKIQKLAGRGGARM *SQLLGRLRRKNHLNPGGGGSSEPRWRYCTPVW VTGRLHLKKKKKKKKGLSMYSHTPQKKPLVPTL ATGFSESKDHIF*CNTARSLEKKIIVVFKIFLYC *CIIIEKLLNMRIKILFTGFVFQSL

Frame 1

PPARGAALPRALARACSPPRRSQPALRPPRSEL GGSDSGLAAPRAGSAPRTPGAQRPAPRRAERTM PQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDD KSRDSAAGPERDLAELKSSLVNESEGAAGGAGI PGVPGAGAGARGEAEALGREHAAQRLFPDKLPE PLEDGLKAPECTSGMYKETVYSAFNLLMHYPPPS GAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNS PHPTPAPADISQKQVHRPLQTPDLSGFYSLTSG SMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPA IVPPSGKQELQPFDRNLKTQAESKAEKEAKKPT IKKPLNAFMLYMKEMRAKVIAECTLKESAAINQ ILGRRWHALSREEQAKYYELARKERQLHMQLYPG WSARDNYGKKKRRSREKHQESTTGGKRNAFGTY PEKAAAPAPFLPMTVL*AAPGPQLPRTHPHTIC CPASPQNCLLALRSRHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDRWPSRHRTPGRLQE PTP*K*QRPRSHGNWPGVLLTSSQGPDPEDFRG CRTSA*TWGHRFKLLQVVGIRSVLMCHLIKGIPC TYGCLHLFFVPSVLPARSLCLPSFSAIGQRWAE LSLATFSTHLPHPPLPHPPHSDTSWTKNELVCQ TTCEHGHKHKAQDDSSSKEMEKLCL*KQKQNQLL LISWTRGSPLL*SQELARSRKGNGIG*V*AYQP KQQK*SDTTLSGKLGRGGCI*L*FKLFGSVP*E THQPKKLWPQACH*QLQSTVQRSHGPNPVCTPPH SQSLFHNSISSSSMAVQPAPGQLERANPKPHDS QSLSFSIQSAWPAPVSPWGCGTEDHYN*IKEPR KPPVVDNRFSP*PTLTHF*AKLQPSALKNKSLI* FLFFA*IQRKRAAGPGAVAHACNPSTLAGRGRW IT*RQ*FETSLANMVKPCIY*KYKN*PDVVVRA CNPSYSGG*GGRIT*TREAEVPVSRDGAIALQSG *QGDCISKKKKKKKKGCPCIHTPLKKSL*FLL* PLVSQNPKITYSSVTLQEVLRKRLL*CSKYFCI VNASS*KNF*T*E*RYFLLGLFFKA*

Frame 2

RQLAEPLCPAP*PAPAARPGGVSPRSARRDPSS EVRTPGSPPPGPAPRPALPAPSAPRPGGRSAPC RSWTPAGAARAAATTSARRTSCWPSRMKARSRT TRAATAPPVPSATWPSSSRRS*TSPRARPAAQGS RGSRGPAPGPAARPRLSGGNTLRRDSSRTNFQS PWRTA*RPRSAPAACTKRPSTPPSICSCITHPP REQGSTPSRSPRCTRPISPPTVSPNSLSTNISTA HIPPLHLRTSARSKFTGLCRPLTSLASTP*PQA AWGSSPTL*AGSPTHP*C*VLVYLVTQQPSPTR PLCPPQGSRSCSPSTAT*RHKQSPRQRRRPRSQP SRSPSMPSCCT*RR*EPRSLQSAHLRRALPSTR SWAAGGTRCREKSRPSTMSWPARRGSCTCSYTQ AGQRGTTTGRRRGGRGKSTKNPPQEEKEMHSVLT RRRPLPQPRSFR*QCSRLPRVPSSPGLTLIPSA APLPHRTAY*PCGAGTYIPRSLHCSQPPNPRAP TGPPQHPAEHTGTATGISETGGLAGTGHLAASRS LPPESDRDPDLMETGQGSC*RHLRVQTLKISEA AGLLPEPGVIDSNCSKWWESDLS*CVI*LRESL VPMAACIYSLYHLSCQPEASASLAFLL*VRDGLN *A*LPSLPISPIPHCHTLPIQTLHGPRMSWFVK QHVSMVTSTKLKMTALLRKWRSSVYKNKNKTSC YS*VGPEEAPYYDLRSLQEAGRGME*VKFRPINL SNRNNLTLPYQANWGGEGVSSSSSNYLEVFPEK PTSLRSSGPRLVTSSCSQQFKEVMAQIQCAPLP IHRAFFTIPFPVHLWQSSQLLGSLRGQTQNLMTA RACLSAFSPPGRLQFPHGAAGQRTITTRSRSPE NLQ*WTTGFHHSLR*PIFEPSFNPQP*KTSL*F NFCFLPKSKEKGLPGQARWLTPVIPALWQAEAGG SPDVSSLRPAWPTW*NPVSTKNTKISRTWWCAH VIPATREAEAEESLEPGRRRFQ*AEMALLHSSL GNRETASQKKKKKKKRAVHVFTHPSKKAFSSYFS HWFLRIQRSHILV*HCKKS*EKDYCSVQNIFVL LMHHHRKTFKHENKDTFYWVCFSKP

Sequence NM_201634

GCCCAGGTGACTGACTAATCCGCCGCCTTCAGGAGACAGAATTGGCCAAGGCCTGAAGGCCCCGGAGTGCACCAGCGGCATGTACAAAGAGACCGTCTAC TCCGCCTTCAATCTGCTCATGCATTACCCACCCCCCTCGGGAGCAGGGCAGCACCCCCAGCCGCAGCCCCCGCTGCACAAGGCCAATCAGCCCCCCCACG GTGTCCCCCAACTCTCTCTCTACGAACATTTCAACAGCCCACATCCCACCCCTGCACCTGCGGACATCAGCCAGAAGCAAGTTCACAGGCCTCTGCAGAC CCCTGACCTCTCTGGCTTCTACTCCCTGACCTCAGGCAGCATGGGGCAGCTCCCCCACACTGTGAGCTGGTTCACCCACCCATCCTTGATGCTAGGTTCT GGTGTACCTGGTCACCCAGCAGCCATCCCCCACCCGGCCATTGTGCCCCCCTCAGGGAAGCAGGAGCTGCAGCCCTTCGACCGCAACCTGAAGACACAAG CAGAGTCCAAGGCAGAGAAGGAGGCCAAGAAGCCAACCATCAAGAAGCCCCTCAATGCCTTCATGCTGTACATGAAGGAGATGAGAGCCAAGGTCATTGC AGAGTGCACACTTAAGGAGAGCGCTGCCATCAACCAGATCCTGGGCCGCAGGTGGCACGCGCTGTCGCGAGAAGAGCAGGCCAAGTACTATGAGCTGGCC CGCAAGGAGAGGCAGCTGCACATGCAGCTATACCCAGGCTGGTCAGCGCGGGACAACTACGGGAAGAAGAAGAGGCGGTCGAGGGAAAAGCACCAAGAAT CCACCACAGACCCTGGCTCGCCTAAGAAATGCCGTGCTCGCTTTGGCCTCAACCAGCAGACGGATTGGTGTGGTCCGTGCAGATAACTCTCTTCACTATT CCTAGGAGGAAAAAGAAATGCATTCGGTACTTACCCGGAGAAGGCCGCTGCCCCAGCCCCGTTCCTTCCGATGACAGTGCTCTAGGCTGCCCCGGGTCCC CAGCTCCCCAGGACTCACCCTCATACCATCTGCTGCCCCGCTTCCCCACAGAACTGCTTACTAGCCCTGCGGAGCCGGCACCTACATCCCCAGGTCTCTC CACTGCTCTCAGCCTCCCAACCCCAGGGCCCCCACAGGCCCCCCGCAGCACCCTGCAGAGCACACAGGTACAGCAACAGGAATCTCAGAGACAGGTGGCC TAGCAGGCACAGGACACCTGGCCGCCTCCAGGAGCCTACCCCCTGAAAGTGACAGAGACCCAGATCTCATGGAAACTGGCCAGGGGTCCTGTTAACGTCA TCTCAGGGTCCAGACCCTGAAGATTTCAGAGGCTGCAGGACTTCTGCCTGAACCTGGGGTCATCGATTCAAACTGCTCCAAGTGGTGGGAATCAGATCTG TCTTGATGTGTCATCTAATTAAGGGAATCCCTTGTACCTATGGCTGCCTGCATCTATTCTTTGTACCATCTGTCTTGCCAGCCAGAAGCCTCTGCCTCCC TAGCTTTTCTGCTATAGGTCAGAGATGGGCTGAACTGAGCCTAGCTACCTTCTCTACCCATCTCCCCCATCCCCCACTGCCACACCCTCCCCATTCAGAC ACTTCATGGACCAAGAATGAGCTGGTTTGTCAAACAACATGTGAGCATGGTCACAAGCACAAAGCTCAAGATGACAGCTCTTCTAAGGAAATGGAGAAGC TCTGTTTATAAAAACAAAAACAAAACCAGCTGCTACTCATAAGTTGGACCAGAGGAAGCCCCTTACTATGATCTCAGGAGCTTGCAAGAAGCAGGAAGGG GAATGGAATAGGTTAAGTTTAGGCCTATCAACCTAAGCAACAGAAATAATCTGACACTACCTTATCAGGCAAATTGGGGAGGGGAGGGTGTATCTAGCTC TAGTTCAAATTATTTGGAAGTGTTCCCTGAGAAACCCACCAGCCTAAGAAGCTCTGGCCCCAGGCTTGTCACTAGCAGCTGCAGTCAACAGTTCAAAGAA GTCATGGCCCAAATCCAGTGTGCACCCCTCCCCATTCACAGAGCCTTTTTCACAATTCCATTTCCAGTTCATCTATGGCAGTCCAGCCAGCTCCTGGGCA GCTTGAGAGGGCAAACCCAAAACCTCATGACAGCCAGAGCCTGTCTTTCAGCATTCAGTCCGCCTGGCCGGCTCCAGTTTCCCCATGGGGCTGCGGGACA GAGGACCATTACAACTAGATCAAGGAGCCCAGAAAACCTCCAGTAGTGGACAACAGGTTTTCACCATAGCCTACGTTAACCCATTTTTGAGCCAAGCTTC AACCCTCAGCCTTGAAAAACAAGTCTTTAATTTAATTTTTGTTTTTTGCCTAAATCCAAAGAAAAAGGGCTGCCGGGCCAGGCGCGGTGGCTCACGCCTG TAATCCCAGCACTTTGGCAGGCCGAGGCAGGTGGATCACCTGACGTCAGTAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTATCTACTAAAAA TACAAAAATTAGCCGGACGTGGTGGTGCGCGCATGTAATCCCAGCTACTCGGGAGGCTGAGGCGGAAGAATCACTTGAACCCGGGAGGCGGAGGTTCCAG TGAGCCGAGATGGCGCTATTGCACTCCAGTCTGGGTAACAGGGAGACTGCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGGGCTGTCCATGTATTCACAC ACCCCTCAAAAAAAGCCTTTAGTTCCTACTTTAGCCACTGGTTTCTCAGAATCCAAAGATCACATATTCTAGTGTAACACTGCAAGAAGTCTTGAGAAAA AGATTATTGTAGTGTTCAAAATATTTTTGTATTGTTAATGCATCATCATAGAAAAACTTTTAAACATGAGAATAAAGATACTTTTTACTGGGTTTGTTTT TCAAAGCCTGA

refseq_TCF7.F1 (forward primer)
refseq_TCF7.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

AQVTD*SAAFRRQNWPRPEGPGVHQRHVQRDRL LRLQSAHALPTPLGSRAAPPAAAPAAQGQSAPPR CPPTLSLRTFQQPTSHPCTCGHQPEASSQASAD P*PLWLLLPDLRQHGAAPPHCELVHPPILDARF WCTWSPSSHPPPGHCAPLREAGAAALRPQPEDTS RVQGREGGQEANHQEAPQCLHAVHEGDESQGHC RVHT*GERCHQPDPGPQVARAVARRAGQVL*AG PQGEAAAHAAIPRLVSAGQLREEEEAVEGKAPRI HHRPWLA*EMPCSLWPQPADGLVWSVQITLFTI PRRKKKCIRYLPGEGRCPSPVPSDDSALGCPGS PAPQDSPSYHLLPRFPTELLTSPAEPAPTSPGLS TALSLPTPGPPQAPRSTLQSTQVQQQESQRQVA *QAQDTWPPPGAYPLKVTETQISWKLARGPVNV ISGSRP*RFQRLQDFCLNLGSSIQTAPSGGNQIC LDVSSN*GNPLYLWLPASILCTICLASQKPLPP *LFCYRSEMG*TEPSYLLYPSPPSPTATPSPFR HFMDQE*AGLSNNM*AWSQAQSSR*QLF*GNGEA LFIKTKTKPAATHKLDQRKPLTMISGACKKQEG EWNRLSLGLST*ATEII*HYLIRQIGEGRVYLA LVQIIWKCSLRNPPA*EALAPGLSLAAAVNSSKK SWPKSSVHPSPFTEPFSQFHFQFIYGSPASSWA A*EGKPKTS*QPEPVFQHSVRLAGSSFPMGLRD RGPLQLDQGAQKTSSSGQQVFTIAYVNPFLSQAS TLSLEKQVFNLIFVFCLNPKKKGCRARRGGSRL *SQHFGRPRQVDHLTSVV*DQPGQHGETLYLLK IQKLAGRGGARM*SQLLGRLRRKNHLNPGGGGSS EPRWRYCTPVWVTGRLHLKKKKKKKKGLSMYSH TPQKKPLVPTLATGFSESKDHIF*CNTARSLEK KIIVVFKIFLYC*CIIIEKLLNMRIKILFTGFVF QSL

Frame 1

PR*LTNPPPSGDRIGQGLKAPECTSGMYKETVY SAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPH GVPQLSLYEHFNSPHPTPAPADISQKQVHRPLQT PDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGS GVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQ AESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIA ECTLKESAAINQILGRRWHALSREEQAKYYELA RKERQLHMQLYPGWSARDNYGKKKRRSREKHQE STTDPGSPKKCRARFGLNQQTDWCGPCR*LSSLF LGGKRNAFGTYPEKAAAPAPFLPMTVL*AAPGP QLPRTHPHTICCPASPQNCLLALRSRHLHPQVS PLLSASQPQGPHRPPAAPCRAHRYSNRNLRDRWP SRHRTPGRLQEPTP*K*QRPRSHGNWPGVLLTS SQGPDPEDFRGCRTSA*TWGHRFKLLQVVGIRS VLMCHLIKGIPCTYGCLHLFFVPSVLPARSLCLP SFSAIGQRWAELSLATFSTHLPHPPLPHPPHSD TSWTKNELVCQTTCEHGHKHKAQDDSSSKEMEK LCL*KQKQNQLLLISWTRGSPLL*SQELARSRKG NGIG*V*AYQPKQQK*SDTTLSGKLGRGGCI*L *FKLFGSVP*ETHQPKKLWPQACH*QLQSTVQR SHGPNPVCTPPHSQSLFHNSISSSSMAVQPAPGQ LERANPKPHDSQSLSFSIQSAWPAPVSPWGCGT EDHYN*IKEPRKPPVVDNRFSP*PTLTHF*AKL QPSALKNKSLI*FLFFA*IQRKRAAGPGAVAHAC NPSTLAGRGRWIT*RQ*FETSLANMVKPCIY*K YKN*PDVVVRACNPSYSGG*GGRIT*TREAEVP VSRDGAIALQSG*QGDCISKKKKKKKKGCPCIHT PLKKSL*FLL*PLVSQNPKITYSSVTLQEVLRK RLL*CSKYFCIVNASS*KNF*T*E*RYFLLGLF FKA*

Frame 2

PGD*LIRRLQETELAKA*RPRSAPAACTKRPST PPSICSCITHPPREQGSTPSRSPRCTRPISPPT VSPNSLSTNISTAHIPPLHLRTSARSKFTGLCR PLTSLASTP*PQAAWGSSPTL*AGSPTHP*C*VL VYLVTQQPSPTRPLCPPQGSRSCSPSTAT*RHK QSPRQRRRPRSQPSRSPSMPSCCT*RR*EPRSL QSAHLRRALPSTRSWAAGGTRCREKSRPSTMSWP ARRGSCTCSYTQAGQRGTTTGRRRGGRGKSTKN PPQTLARLRNAVLALASTSRRIGVVRADNSLHY S*EEKEMHSVLTRRRPLPQPRSFR*QCSRLPRVP SSPGLTLIPSAAPLPHRTAY*PCGAGTYIPRSL HCSQPPNPRAPTGPPQHPAEHTGTATGISETGG LAGTGHLAASRSLPPESDRDPDLMETGQGSC*RH LRVQTLKISEAAGLLPEPGVIDSNCSKWWESDL S*CVI*LRESLVPMAACIYSLYHLSCQPEASAS LAFLL*VRDGLN*A*LPSLPISPIPHCHTLPIQT LHGPRMSWFVKQHVSMVTSTKLKMTALLRKWRS SVYKNKNKTSCYS*VGPEEAPYYDLRSLQEAGR GME*VKFRPINLSNRNNLTLPYQANWGGEGVSSS SSNYLEVFPEKPTSLRSSGPRLVTSSCSQQFKE VMAQIQCAPLPIHRAFFTIPFPVHLWQSSQLLG SLRGQTQNLMTARACLSAFSPPGRLQFPHGAAGQ RTITTRSRSPENLQ*WTTGFHHSLR*PIFEPSF NPQP*KTSL*FNFCFLPKSKEKGLPGQARWLTP VIPALWQAEAGGSPDVSSLRPAWPTW*NPVSTKN TKISRTWWCAHVIPATREAEAEESLEPGRRRFQ *AEMALLHSSLGNRETASQKKKKKKKRAVHVFT HPSKKAFSSYFSHWFLRIQRSHILV*HCKKS*EK DYCSVQNIFVLLMHHHRKTFKHENKDTFYWVCF SKP