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Sequences

Sequence NM_152826

AGTTGTTGTTGCGGCTTCCGCCGCGGGTGGAAGAAGATGGCGTCGGGTGGTGGTGGCTGTAGCGCTTCGGAGAGACTGCCTCCGCCCTTCCCCGGCCTGG AGCCGGAGTCCGAGGGGGCGGCCGGGGGATCAGAACCCGAGGCTGGGGACAGCGACACCGAGGGGGAGGACATTTTCACCGGCGCCGCGGTGGTCAGTAA ACATCAGTCTCCAAAGATAACTACATCCCTTCTTCCCATCAACAATGGCTCCAAAGAAAATGGGATCCATGAAGAACAAGACCAAGAGCCACAGGATCTC TTTGCAGATGCCACAGTGGAGCTATCCTTGGACAGCACACAAAATAATCAGAAGAAGGTGCTAGCCAAAACACTCATTTCTCTTCCTCCTCAGGAAGCCA CAAATTCTTCGAAGCCCCAGCCAACCTATGAGGAGCTAGAGGAAGAAGAACAGGAGGATCAATTTGATTTGACAGTCGGTATAACTGATCCTGAGAAGAT AGGGGATGGTATGAATGCATATGTAGCCTACAAAGTTACAACACAGACAAGCTTACCATTGTTCAGAAGCAAACAGTTTGCAGTAAAAAGAAGATTTAGT GACTTTCTGGGTCTTTATGAGAAGCTTTCCGAGAAGCACTCTCAGAATGGCTTCATTGTCCCTCCGCCCCCGGAGAAGAGCCTCATAGGGATGACAAAAG TGAAAGTTGGGAAGGAAGATTCTTCTTCTGCAGAATTTCTTGAAAAACGGAGGGCCGCTTTAGAAAGGTACCTTCAGAGGATTGTAAATCATCCTACCAT GTTACAGGACCCTGACGTCAGAGAGTTCTTGGAAAAAGAAGAGCTGCCACGTGCCGTGGGTACCCAGACATTGAGTGGTGCTGGTCTCCTCAAGATGTTC AACAAAGCCACAGATGCCGTCAGCAAAATGACCATCAAGATGAATGAATCAGACATTTGGTTTGAGGAGAAGCTCCAGGAGGTAGAGTGTGAGGAGCAGC GCTTACGGAAACTGCATGCTGTTGTAGAAACTCTAGTCAACCATAGGAAAGAGCTAGCGCTGAACACAGCCCAGTTTGCAAAGAGTCTAGCCATGCTTGG GAGCTCTGAGGACAACACGGCATTGTCACGGGCACTCTCCCAGCTGGCTGAGGTGGAAGAAAAAATTGAGCAGCTCCACCAGGAACAGGCCAACAATGAC TTCTTCCTCCTTGCTGAGCTCCTGAGTGACTACATTCGCCTCCTGGCCATAGTCCGCTGGGAGTCTCGGGTGACTCAATATGAAAGGGACTTCGAGAGGA TTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTCAAGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTC ACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGCCATCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCC TTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGATGCATCCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTC CCCAGTTACTCTAACCGTTATTTCATTTAGCTTCCATATATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTG GAATTATGGGATGGGGTGGAGTATTGATATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACT CCTGATGGTGCCATGAAAAGGTTATGTAATAAAATATTTTAAAATCAGGTCACATGACTCAGAATGTTGGTGGTTTTTGCTTAGGCTGGGGAGCAGTTGG GAATCAGGTCTGGAATACTCCTAACCAAGAAGTTGCCCAGGTATAGTAAGTTTTTCTCTACCGTTCACAAGTTTTGTGCTGCTGCTTCCCTCTGGAAATG GGGTTTCTTTCTCTCCGCCTACCTCAGCTACCTGTTCTGAGGGTCTCAATCTGTTTCGTATTCCCACTTCTTTAGGGAAGGAGTTTTAAAAACATCTCTT AAAATAAGAGGAGCAAAATCTATTAAAACCTATTCTCCTGCAAAGGAGGCAGAGACTTTCTCTCTCTCTTTTTTTTTTTTTTTTGGTGTCCCTATCATTA AGCAAGAGCCTTTCTCTTTTATTCTTCCTGCTTCCCTAAGCTGCTCAGGGTTCTCTGAGTCTTGCCCTCTGATGGCAAGTCTTATATATAACTAAACCTA TTTTTGTCACCCATCAAAACACATCCTCAGTAGACTGTGTGAAGGTGTGAAGGTCTGATAATGACTTGATGCTTTGTCTCCATAGACATGAAAGCCATGC CCTCTGCCTCTAGATAGGGTGATCCAAGAGCTCCTGAACCTTAGGAGGTTCAAAGAAGCTCTACTGTCTGTGCCCAGGAGGTAGCCTGCCAGCAAGAGCC CTCAGGAGTTGCACACACAGCCAAAGGGTGTTCACACAGATCTCTGCCGGTCTAGCCAGGGGAGGCCAGAGTCTCGTCAGTCAAGGATGGGCTTCCCCCT TAGCTGTGTCCACAGCTGCTCAAGCTATACTGGTCAGAGTGGGCTTTGAAGCTCCTTTGTGAGCTCGAGCTGCTGACTGCCACTATGGGAGCCTTGCCAC CTCCAGCCCCTCCATCCCAAAGACGCTCCTGCCACTGGGGCCCCAGGTCCTGCTGTATCAGTTCTCTTTGGTGGGGGGCTAAGGTTTGGGGCGAGGCAAC CTGAGACAAGAAAACGCAGTAAACATTCTGATTCCCTGTACACAGATGCAGCACCAGGGGAAGGGCCAGTGGTGCAAGTATTTCTTTTTAACAGGTGAAG TTTTTGGAAAAAGTCACTCTCCCTACCCCTCAGTATCCTTACCATCAACTTTGGTTTTATCCTTCCAGTCTTTATTATATGCTTGCTTTTACATAGTTGT AATAATATACACATAAAGTATTTTGTATCCTGCTTTTATCATTCAACATTGTACATGTTATAAGCATTTTACTATATTGTTATATATCTTCACAAAGTTG ATCTGTAAAGCTGTGTAATTTGAAGGCATCCATAGGGTGACTGTACCATAATTTTGATTCATCCCTTGTTGTTGGATTCTTGGTCAGGGGTTGTTTGTTT TGTTTTATTGGTAACTTTAAAATTTTGAATACAATTTCAGATTTACAGAAAAGTTGCAGGAATATCACAAAGAACTCCTATATATCTTTTATCCAGATTT ACTGAGTGTTTACATTTTATCCCATTTGCCTTATCTATATTTCATGTTGCATTTTCTTAATCATTTGAGAATAATTTGCACAGATACCCCATTATGCCCA AAACAGTATGCATTTCCCTAAGAACAGGACATTCTCTTCTAAGAGAAGAAGAGAATTACTTTAAGCATTATTCAGTATTTTTTTAAGTATTATTATCAAA ATCAGGAAGTTTAACAGTGATTTAATACTGTTATCTAACCCATGATTCATATTTAAATTTTGCCATTTATCCCAATAATGTCCTTTGTAGCCATTCTTTT ACCTTGTGCAGGATCATGTTACATTTGTAAACGTGTGTCTCTCAATACTGCAGATTCCTCAACTTTCTTTTGTCTTTCATTACCATGACATTTTTGAAGA ATACAGGCTATTTTGTCGAATGTTCCTCAGTTTGGATTTGTGTGATGGTTCCGCATGACTAGGTGAGGGTTTTGCATTCTGGGTGGGAATATCACAGAAG CAGTGTGTCGTCAGTGCGTCGTAATCAGCATATAATGTCAGTTGGTCCCATTAATGTTGTTAACTCTGTTCACCGCTTAGGTTGGTGTCTGCCAGATTTC ATTTTAAATTTACGATTTCCTCTTTGTAATTTACAAGTAATTTGTGGGGAGATACTTTGAGACTATATAAGTATTTTGTTCCTCATTCACCAGTTATATA GTATCAGTTGATTAGTCTTGTCCCAGTTATTACTGTCATGATTGACCAACATGATTTCCTAACTCCATAATGCCTTCTACATTTATTGGTTGACATTCTA CATACAAAGAAAAACATCCTTTCTCACCATTTATTTATTCACTTGTTTATCAATATGGATGCAGGGATTCCTGTTTTACTCAGAGTTGCAAGCCATTGCT TTGATTTTATCTTGATTCTCAAATTGTCCCAGATTTATAGCGGCCTCTTGTGTGTTTGTAGCTTGCTCCCATCATGTTTTGAGTACTTTCTTACCTTCTG GCATAACAAGATGTTCCAGGCTCATCTTGAATGTTCCCTACCCTAGCCCTGGAATCAGCCATTTCTCCAGGGAGTCTTGGTTCCTTATAATGGAGAATGG TATTTATTTATTTTTATTTGATTTGATTATTATTACTATTTTTGAGACAGAGTCTCGCTCTTGTCGCCCAGGCTGGATTGCAATGGCACAATCTCAGCTC ACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGTGCCTGCCCCCACACCCAGCTAATTTTTGC ATTTTTGGTAGAAATGGGGGTTTTACCATGTTGGGGAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCCCACCTCAACCTCCCAAAGTGCTGGGAT TACAGGTGTGAGCCACCATACCCAGCCAGAGAATGTTATTTAGAAACCAAGATCTGGGTGCCAAATGTGCTGCTTGTTACTGGAATGTCATTGCCTCTAG GCTCTCACCATACAGTGCAAAGAGATGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGATAGATATAGATAGATAGATAGATTGATTG ATTTGTAGAAACAAGATAGGTTAGAGATACCTGACATAAATAGATACTAAAAATCATGAATTCACACTGATGCTTTGAGACCAGCCCTGTAGGTTTATTC CAGTCTGCCCCCTTTTCCATGTTGTTAACTCTTTCCTCCAGAGAGACAAAGATTTCAGGTTGCTTTGTTAAGTTCCATCTAATGATCATTCTGACGTAAG TCTGTTTTTCTTATTTCCTTGGAATGATGTCTCCTCTGGTTTCAGAACTTCCTCCTCTGCTTCCTGTATCCTGAGGCTGGCGGGGCCAGTTGTCTTTAGG GCTTGTGCATTTTTGTAAAGAGCTTGCACGTGTGGAAATCAAGTAGGCCAGTAGTGGGTTAGGGGTACTGAGCCAGAAGCCTCTACAAGGAATAACAGGA GCACAAAGGAAGAAGGTGGTATTCCAGCTGGGGACCCAGGAGGGAGGACTTTGTGGAGAACCTGATGCTTGAACTGAGTCTAAAAGGTGTAAAAGTGTTT GTTGCTTCTGCCTCCCTGTCTGTCTGGCAGGGTGAGGTAGGCGCATCTAGGGAAATGTCAAGTGGCTTGGTGTAGGGTAAAGTCAGTGAGGCCCATGGAG AAAAACGAGCAGGAGCCACATCACATGGGTGTCTGATAGGACCTGGGAGGCGCTTTCCACATTACCATTGTCGCTTCGTGATCTGGACACACCAGAAGGC GTGAGACTGGAGGCAGGAAGAGCAGCCAGGCTTATCCCTACCCTCAGGAGAGCTGAAAAGGGCAGGTATGGTGGGGCCAGAGCTCAGGAGAGTTTCGGAA CCACTGAGATCGGTCCTTGATTTGATGAGAGGCTTGAGGGGAGAGGGAGGTAGCTAGGATGCCCCGCAAGCTTCTGGCCCAGACACTGGGCAGACAATGA AACCCTTTGTAACACATGAGGCAATAGGTTTGGGGCAGATGGGAGGGGAAGCAGTGGTGGGGGCAGTGAGTGCTGAAGGTGTTTTAAGAAGCGGCTCTGG GCCAGGCACAGTGGCTTATGCCTGTATTCCTAGCATTTTGGGAGGCCGAGGTGGGAGAATCACTTGAGCCCAAGAATTTGAGACCAGCCTGGGGAATATA GTGAGACCCTGTCCCTACAAAAATAAAAACAACTAGCTGGGTGTGTGGTGGTGCATGCCTGTAGGCCCAGCTACGCGGGAACATCACCTGAGCCCAGGAG GTTGAGGTTGCAGTGAGCTACAGTTGCGCCACTGCACTCCAGCCTAGGTGACAGAGCAAGATCTTGTCTCAAAAAAAAAAGCAGCTCTGGATGGGAAGGG AGGCCAGTTGCTTTAAGTAGGGGAGATAGAGTTAAAGGAGGCTTTGTTTTATTTAAAGGTGGGACAAACTTAAGCATGTTAATAAAATTCAGAGAAGAGA AAGAGAATGACTATCAGAGCCATGTTTGGAAGAAAATGGGGTCCAGAGCACAGGAAGGGGACCTGTGTTCAGAGGGTGCCTCACTGCTGAGGCCACAGGA AAGAATCTGTAGGTGGAGGGGAGGCCGAAGAGGGGAAGTTTCATGCTTGATAATTAAAATTTTCTGAGATAGGAATGTCATATTTACCTATTTAAGCCAA GTTTTTTTAGATAAAAGGTATGGAACCTGCTTTCCCCTTGGCTAGTTCAGCGTTTGGGCTCCGGAGTGCTGAAGATGAGGACTGGACTTCGAGCTGGTGT GATCCCAGTATTCAGTGTCAGTACTCAGTGACAAAATAAATGAGAGAAACGGGAATAAGAATTGTCGCCTACACAAAAATACCAGCAACTGTTAACTCTT CCCAGAAGATTTTCATTCTGAATGCTCCTGTAGCTAGGAACCCTAAAAAGTCTTTGAAGCAACTCAAGTTTTAAAAAAGGGGAGGAACTCCTGGAAATCT CAGGATGGGGCCAAGATGTGGCTGGAGAGTGTGTGGTGATGGAGGGCGTGTCTTTTGCCGAGCACACTCAGGGCCCACGGGAAGCCCATAGACTTCAAGG ACATCAAGCCCCAAGGTGGTGGGATTTTCCCCACCAGTACTTGGCAGCCTAGGGGGAAGGGGAGGGCGGGAGAAGATAATGGGGATCCCTGGCTCCAAAC ATAGGAGGACACATCTGTGCTACAGTGCGCACATGCCTGGATGTACACTCTGTCTTTGGAGACACTGGCTAAGATTCTCTGCTCCATGTTTGGACAGGGT CGTGCCTGATCTGAGATAAATGGACAAGAACAACTGAAGCCTGTCTTCTGGTGCATGTGTCACCTGCCGATAACTGCATCTTGTGATAAAGTTGGGTGAT TTACAGTCTCCACCAAATGCTAAACTCTGGGGTCTTACGCCTTTATAACTCCATGGGCCCCAGCAAAGGTTCAGGCTCAAAACAGGTGTCAAATAGATAA CTGTTGAATGATTGTTCCCCAGTTGCAGGCTCTGCCACCTGGCGTTCATACTGTCTGTGAAAGGACCCAGCTCACCTTTCCCTCTTTATCTCCCAGTCCT TCCCAACAGCGCCGACACCTCATGGAAACTGATTGCAAATGTGCTACTTCTCACTTCTGTGTGGCCCGAGGAGGCTGGGTTAATGCTGGGCTTGGTACCT TAAGCACCCTTTCTCCCTTCCCCATCTTCATTCTCAGAATTACACCTGTCTGAAGCAGGCATTTTCCAATGCCCTAGATGGGAATATAAGTGTAAGGAGA TGTGAAGCATTTGCCTGTGTGTCAGAACATTCACTGAGGATCCTCATAGGCACTTCTAGAAACCAAATCCTTGAAGATGACTAACCAGAAATGCCCGTCA TAGCACTGTTTACAGTTGCAAAAACTGAAGCCAATTGAAATGTCCATCAGGAGGGGATTAAATGAATTATGGTACAGTTACACCGTTGAATATTTTACAG CCATTGAAGATGATATATAGCTATATTCATTGACAAGGAAAACTCATATTTTTTAGTGAAAAAAGCAGGTTATAGAATTGCATGATATTCACATTTATAT AAAACTTTATATATGGGAAGGATGTTGATTGAATTGTTAATAACTATGGTCACCTCTAGAGATGGAAGTTTGCATTACCTTTAATTTTTAATACCATTTT GTATTGCTTAAAATTTGTATGTATTATCGTTAAAATAAGAAAAATCAAATAAAGCTATTTTCATTATGGGAAAACAA

refseq_SNX1.F2 (forward primer)
refseq_SNX1.R2 (reverse primer)
Single exon skipping

Frame 0

SCCCGFRRGWKKMASGGGGCSASERLPPPFPGL EPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSK HQSPKITTSLLPINNGSKENGIHEEQDQEPQDL FADATVELSLDSTQNNQKKVLAKTLISLPPQEA TNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKI GDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFS DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTM LQDPDVREFLEKEELPRAVGTQTLSGAGLLKMF NKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLG SSEDNTALSRALSQLAEVEEKIEQLHQEQANND FFLLAELLSDYIRLLAIVRWESRVTQYERDFER ISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYS QQQLAKYWEAFLPEAKAIS*WTKDPRAHLCDAA FLYTVLLHLDGPLVMHPA*AGLNPFLPVPTTNC PQLL*PLFHLASIYIFLPKRIVSCFKQKTYNRWW NYGMGWSIDINI*IQMYIFQDVV*ELGITFSVT PDGAMKRLCNKIF*NQVT*LRMLVVFA*AGEQL GIRSGILLTKKLPRYSKFFSTVHKFCAAASLWKW GFFLSAYLSYLF*GSQSVSYSHFFREGVLKTSL KIRGAKSIKTYSPAKEAETFSLSFFFFFGVPII KQEPFSFILPASLSCSGFSESCPLMASLIYN*TY FCHPSKHILSRLCEGVKV***LDALSP*T*KPC PLPLDRVIQELLNLRRFKEALLSVPRR*PASKS PQELHTQPKGVHTDLCRSSQGRPESRQSRMGFPL SCVHSCSSYTGQSGL*SSFVSSSC*LPLWEPCH LQPLHPKDAPATGAPGPAVSVLFGGGLRFGARQ PETRKRSKHSDSLYTDAAPGEGPVVQVFLFNR*S FWKKSLSLPLSILTINFGFILPVFIICLLLHSC NNIHIKYFVSCFYHSTLYML*AFYYIVIYLHKV DL*SCVI*RHP*GDCTIILIHPLLLDSWSGVVCF VLLVTLKF*IQFQIYRKVAGISQRTPIYLLSRF TECLHFIPFALSIFHVAFS*SFENNLHRYPIMP KTVCISLRTGHSLLREEENYFKHYSVFF*VLLSK SGSLTVI*YCYLTHDSYLNFAIYPNNVLCSHSF TLCRIMLHL*TCVSQYCRFLNFLLSFITMTFLK NTGYFVECSSVWICVMVPHD*VRVLHSGWEYHRS SVSSVRRNQHIMSVGPINVVNSVHRLGWCLPDF ILNLRFPLCNLQVICGEIL*DYISILFLIHQLY SIS*LVLSQLLLS*LTNMIS*LHNAFYIYWLTFY IQRKTSFLTIYLFTCLSIWMQGFLFYSELQAIA LILS*FSNCPRFIAASCVFVACSHHVLSTFLPS GITRCSRLILNVPYPSPGISHFSRESWFLIMENG IYLFLFDLIIITIFETESRSCRPGWIAMAQSQL TATSTYQVQAILLPQPSK*LGLQVPAPTPS*FL HFW*KWGFYHVGEAGLELLTSGDLPTSTSQSAGI TGVSHHTQPENVI*KPRSGCQMCCLLLECHCL* ALTIQCKEMIDR*IDR*IDR*IDDRYR*IDRLI DL*KQDRLEIPDINRY*KS*IHTDALRPAL*VYS SLPPFPCC*LFPPERQRFQVALLSSI**SF*RK SVFLISLE*CLLWFQNFLLCFLYPEAGGASCL* GLCIFVKSLHVWKSSRPVVG*GY*ARSLYKE*QE HKGRRWYSSWGPRREDFVENLMLELSLKGVKVF VASASLSVWQGEVGASREMSSGLV*GKVSEAHG EKRAGATSHGCLIGPGRRFPHYHCRFVIWTHQKA *DWRQEEQPGLSLPSGELKRAGMVGPELRRVSE PLRSVLDLMRGLRGEGGS*DAPQASGPDTGQTM KPFVTHEAIGLGQMGGEAVVGAVSAEGVLRSGSG PGTVAYACIPSILGGRGGRIT*AQEFETSLGNI VRPCPYKNKNN*LGVWWCMPVGPATREHHLSPG G*GCSELQLRHCTPA*VTEQDLVSKKKAALDGKG GQLL*VGEIELKEALFYLKVGQT*AC**NSEKR KRMTIRAMFGRKWGPEHRKGTCVQRVPHC*GHR KESVGGGEAEEGKFHA**LKFSEIGMSYLPI*AK FF*IKGMEPAFPLASSAFGLRSAEDEDWTSSWC DPSIQCQYSVTK*MRETGIRIVAYTKIPATVNS SQKIFILNAPVARNPKKSLKQLKF*KRGGTPGNL RMGPRCGWRVCGDGGRVFCRAHSGPTGSP*TSR TSSPKVVGFSPPVLGSLGGRGGREKIMGIPGSK HRRTHLCYSAHMPGCTLCLWRHWLRFSAPCLDRV VPDLR*MDKNN*SLSSGACVTCR*LHLVIKLGD LQSPPNAKLWGLTPL*LHGPQQRFRLKTGVK*I TVE*LFPSCRLCHLAFILSVKGPSSPFPLYLPVL PNSADTSWKLIANVLLLTSVWPEEAGLMLGLVP *APFLPSPSSFSELHLSEAGIFQCPRWEYKCKE M*SICLCVRTFTEDPHRHF*KPNP*R*LTRNARH STVYSCKN*SQLKCPSGGD*MNYGTVTPLNILQ PLKMIYSYIH*QGKLIFFSEKSRL*NCMIFTFI *NFIYGKDVD*IVNNYGHL*RWKFALPLIFNTIL YCLKFVCIIVKIRKIK*SYFHYGKT

Frame 1

VVVAASAAGGRRWRRVVVAVALRRDCLRPSPAW SRSPRGRPGDQNPRLGTATPRGRTFSPAPRWSV NISLQR*LHPFFPSTMAPKKMGSMKNKTKSHRIS LQMPQWSYPWTAHKIIRRRC*PKHSFLFLLRKP QILRSPSQPMRS*RKKNRRINLI*QSV*LILRR *GMV*MHM*PTKLQHRQAYHCSEANSLQ*KEDLV TFWVFMRSFPRSTLRMASLSLRPRRRAS*G*QK *KLGRKILLLQNFLKNGGPL*KGTFRGL*IILP CYRTLTSESSWKKKSCHVPWVPRH*VVLVSSRCS TKPQMPSAK*PSR*MNQTFGLRRSSRR*SVRSS AYGNCMLL*KL*STIGKS*R*TQPSLQRV*PCL GALRTTRHCHGHSPSWLRWKKKLSSSTRNRPTMT SSSLLSS*VTTFASWP*SAGSLG*LNMKGTSRG FQQWSEKK*YGLRKRNPRTSRTT*SSTLRHSFT HSSSWQSTGKPSFLRQRPSPNGPRTPEPTCVTLP FYTLSSSTLMDP**CILPRLDLTPSSLSPRPTV PSYSNRYFI*LPYIFSYLRE*FPALSKRPTIGG GIMGWGGVLI*IYKYKCIFFRMWFRNWE*RFLLL LMVP*KGYVIKYFKIRSHDSECWWFLLRLGSSW ESGLEYS*PRSCPGIVSFSLPFTSFVLLLPSGN GVSFSPPTSATCSEGLNLFRIPTSLGKEF*KHLL K*EEQNLLKPILLQRRQRLSLSLFFFFLVSLSL SKSLSLLFFLLP*AAQGSLSLAL*WQVLYITKP IFVTHQNTSSVDCVKV*RSDNDLMLCLHRHESHA LCL*IG*SKSS*TLGGSKKLYCLCPGGSLPARA LRSCTHSQRVFTQISAGLARGGQSLVSQGWASP LAVSTAAQAILVRVGFEAPL*ARAADCHYGSLAT SSPSIPKTLLPLGPQVLLYQFSLVGG*GLGRGN LRQENAVNILIPCTQMQHQGKGQWCKYFFLTGE VFGKSHSPYPSVSLPSTLVLSFQSLLYACFYIVV IIYT*SILYPAFIIQHCTCYKHFTILLYIFTKL ICKAV*FEGIHRVTVP*F*FIPCCWILGQGLFV LFYW*L*NFEYNFRFTEKLQEYHKELLYIFYPDL LSVYILSHLPYLYFMLHFLNHLRIICTDTPLCP KQYAFP*EQDILF*EKKRITLSIIQYFFKYYYQ NQEV*Q*FNTVI*PMIHI*ILPFIPIMSFVAILL PCAGSCYICKRVSLNTADSSTFFCLSLP*HF*R IQAILSNVPQFGFV*WFRMTR*GFCILGGNITE AVCRQCVVISI*CQLVPLMLLTLFTA*VGVCQIS F*IYDFLFVIYK*FVGRYFETI*VFCSSFTSYI VSVD*SCPSYYCHD*PT*FPNSIMPSTFIG*HS TYKEKHPFSPFIYSLVYQYGCRDSCFTQSCKPLL *FYLDSQIVPDL*RPLVCL*LAPIMF*VLSYLL A*QDVPGSS*MFPTLALESAISPGSLGSL*WRM VFIYFYLI*LLLLFLRQSLALVAQAGLQWHNLSS LQPPPTRFKQFSCLSLPSSWDYRCLPPHPANFC IFGRNGGFTMLGRLVSNS*PQVICPPQPPKVLG LQV*ATIPSQRMLFRNQDLGAKCAACYWNVIASR LSPYSAKR**IDR*IDR*IDR*MIDIDR*ID*L ICRNKIG*RYLT*IDTKNHEFTLML*DQPCRFI PVCPLFHVVNSFLQRDKDFRLLC*VPSNDHSDVS LFFLFPWNDVSSGFRTSSSASCILRLAGPVVFR ACAFL*RACTCGNQVGQ*WVRGTEPEASTRNNR STKEEGGIPAGDPGGRTLWRT*CLN*V*KV*KCL LLLPPCLSGRVR*AHLGKCQVAWCRVKSVRPME KNEQEPHHMGV**DLGGAFHITIVAS*SGHTRR RETGGRKSSQAYPYPQES*KGQVWWGQSSGEFRN H*DRSLI**EA*GEREVARMPRKLLAQTLGRQ* NPL*HMRQ*VWGRWEGKQWWGQ*VLKVF*EAAL GQAQWLMPVFLAFWEAEVGESLEPKNLRPAWGI* *DPVPTKIKTTSWVCGGACL*AQLRGNIT*AQE VEVAVSYSCATALQPR*QSKILSQKKKQLWMGR EASCFK*GR*S*RRLCFI*RWDKLKHVNKIQRRE RE*LSEPCLEENGVQSTGRGPVFRGCLTAEATG KNL*VEGRPKRGSFMLDN*NFLR*ECHIYLFKP SFFR*KVWNLLSPWLVQRLGSGVLKMRTGLRAGV IPVFSVSTQ*QNK*EKRE*ELSPTQKYQQLLTL PRRFSF*MLL*LGTLKSL*SNSSFKKGEELLEI SGWGQDVAGECVVMEGVSFAEHTQGPREAHRLQG HQAPRWWDFPHQYLAA*GEGEGGRR*WGSLAPN IGGHICATVRTCLDVHSVFGDTG*DSLLHVWTG SCLI*DKWTRTTEACLLVHVSPADNCIL**SWVI YSLHQMLNSGVLRLYNSMGPSKGSGSKQVSNR* LLNDCSPVAGSATWRSYCL*KDPAHLSLFISQS FPTAPTPHGN*LQMCYFSLLCGPRRLG*CWAWYL KHPFSLPHLHSQNYTCLKQAFSNALDGNISVRR CEAFACVSEHSLRILIGTSRNQILEDD*PEMPV IALFTVAKTEAN*NVHQEGIK*IMVQLHR*IFYS H*R*YIAIFIDKENSYFLVKKAGYRIA*YSHLY KTLYMGRMLIELLITMVTSRDGSLHYL*FLIPF CIA*NLYVLSLK*EKSNKAIFIMGKQ

Frame 2

LLLRLPPRVEEDGVGWWWL*RFGETASALPRPG AGVRGGGRGIRTRGWGQRHRGGGHFHRRRGGQ* TSVSKDNYIPSSHQQWLQRKWDP*RTRPRATGS LCRCHSGAILGQHTK*SEEGASQNTHFSSSSGSH KFFEAPANL*GARGRRTGGSI*FDSRYN*S*ED RGWYECICSLQSYNTDKLTIVQKQTVCSKKKI* *LSGSL*EAFREALSEWLHCPSAPGEEPHRDDKS ESWEGRFFFCRIS*KTEGRFRKVPSEDCKSSYH VTGP*RQRVLGKRRAATCRGYPDIEWCWSPQDV QQSHRCRQQNDHQDE*IRHLV*GEAPGGRV*GAA LTETACCCRNSSQP*ERASAEHSPVCKESSHAW EL*GQHGIVTGTLPAG*GGRKN*AAPPGTGQQ* LLPPC*APE*LHSPPGHSPLGVSGDSI*KGLRED FNSGPKRSDTV*EREIQGLQEPRDQVP*DTPLL TAAAGKVLGSLPS*GKGHLLMDQGPQSPPV*RC LFIHCPPPP*WTPSDASCLGWT*PLPPCPHDQLS PVTLTVISFSFHIYFLT*ENSFLL*AKDLQ*VV ELWDGVEY*YKYINTNVYFSGCGLGTGNNVFCY S*WCHEKVM**NILKSGHMTQNVGGFCLGWGAVG NQVWNTPNQEVAQV**VFLYRSQVLCCCFPLEM GFLSLRLPQLPVLRVSICFVFPLL*GRSFKNIS *NKRSKIY*NLFSCKGGRDFLSLFFFFFWCPYH* ARAFLFYSSCFPKLLRVL*VLPSDGKSYI*LNL FLSPIKTHPQ*TV*RCEGLIMT*CFVSIDMKAM PSASR*GDPRAPEP*EVQRSSTVCAQEVACQQEP SGVAHTAKGCSHRSLPV*PGEARVSSVKDGLPP *LCPQLLKLYWSEWALKLLCELELLTATMGALP PPAPPSQRRSCHWGPRSCCISSLWWGAKVWGEAT *DKKTQ*TF*FPVHRCSTRGRASGASISF*QVK FLEKVTLPTPQYPYHQLWFYPSSLYYMLAFT*L **YTHKVFCILLLSFNIVHVISILLYCYISSQS* SVKLCNLKASIG*LYHNFDSSLVVGFLVRGCLF CFIGNFKILNTISDLQKSCRNITKNSYISFIQI Y*VFTFYPICLIYISCCIFLII*E*FAQIPHYAQ NSMHFPKNRTFSSKRRRELL*ALFSIFLSIIIK IRKFNSDLILLSNP*FIFKFCHLSQ*CPL*PFF YLVQDHVTFVNVCLSILQIPQLSFVFHYHDIFEE YRLFCRMFLSLDLCDGSA*LGEGFAFWVGISQK QCVVSAS*SAYNVSWSH*CC*LCSPLRLVSARF HFKFTISSL*FTSNLWGDTLRLYKYFVPHSPVI* YQLISLVPVITVMIDQHDFLTP*CLLHLLVDIL HTKKNILSHHLFIHLFINMDAGIPVLLRVASHC FDFILILKLSQIYSGLLCVCSLLPSCFEYFLTFW HNKMFQAHLECSLP*PWNQPFLQGVLVPYNGEW YLFIFI*FDYYYYF*DRVSLLSPRLDCNGTISA HCNLHLPGSSNSPASAFQVAGITGACPHTQLIFA FLVEMGVLPCWGGWSRTPDLR*SAHLNLPKCWD YRCEPPYPARECYLETKIWVPNVLLVTGMSLPL GSHHTVQRDDR*IDR*IDR*IDR**I*IDR*ID* FVETR*VRDT*HK*ILKIMNSH*CFETSPVGLF QSAPFSMLLTLSSRETKISGCFVKFHLMIILT* VCFSYFLGMMSPLVSELPPLLPVS*GWRGQLSLG LVHFCKELARVEIK*ASSGLGVLSQKPLQGITG AQRKKVVFQLGTQEGGLCGEPDA*TESKRCKSV CCFCLPVCLAG*GRRI*GNVKWLGVG*SQ*GPWR KTSRSHITWVSDRTWEALSTLPLSLRDLDTPEG VRLEAGRAARLIPTLRRAEKGRYGGARAQESFG TTEIGP*FDERLEGRGR*LGCPASFWPRHWADNE TLCNT*GNRFGADGRGSSGGGSEC*RCFKKRLW ARHSGLCLYS*HFGRPRWENHLSPRI*DQPGEY SETLSLQK*KQLAGCVVVHACRPSYAGTSPEPRR LRLQ*ATVAPLHSSLGDRARSCLKKKSSSGWEG RPVALSRGDRVKGGFVLFKGGTNLSMLIKFREE KENDYQSHVWKKMGSRAQEGDLCSEGASLLRPQE RICRWRGGRRGEVSCLIIKIF*DRNVIFTYLSQ VFLDKRYGTCFPLG*FSVWAPEC*R*GLDFELV *SQYSVSVLSDKINERNGNKNCRLHKNTSNC*LF PEDFHSECSCS*EP*KVFEATQVLKKGRNSWKS QDGAKMWLESVW*WRACLLPSTLRAHGKPIDFK DIKPQGGGIFPTSTWQPRGKGRAGEDNGDPWLQT *EDTSVLQCAHAWMYTLSLETLAKILCSMFGQG RA*SEINGQEQLKPVFWCMCHLPITASCDKVG* FTVSTKC*TLGSYAFITPWAPAKVQAQNRCQIDN C*MIVPQLQALPPGVHTVCERTQLTFPSLSPSP SQQRRHLMETDCKCATSHFCVARGGWVNAGLGT LSTLSPFPIFILRITPV*SRHFPMP*MGI*V*GD VKHLPVCQNIH*GSS*ALLETKSLKMTNQKCPS *HCLQLQKLKPIEMSIRRGLNELWYSYTVEYFT AIEDDI*LYSLTRKTHIF**KKQVIELHDIHIYI KLYIWEGC*LNC**LWSPLEMEVCITFNF*YHF VLLKICMYYR*NKKNQIKLFSLWEN

Sequence NM_148955

AGTTGTTGTTGCGGCTTCCGCCGCGGGTGGAAGAAGATGGCGTCGGGTGGTGGTGGCTGTAGCGCTTCGGAGAGACTGCCTCCGCCCTTCCCCGGCCTGG AGCCGGAGTCCGAGGGGGCGGCCGGGGGATCAGAACCCGAGGCTGGGGACAGCGACACCGAGGGGGAGGACATTTTCACCGGCGCCGCGGTGGTCAGTAA ACATCAGTCTCCAAAGATAACTACATCCCTTCTTCCCATCAACAATGGCTCCAAAGAAAATGGGATCCATGAAGAACAAGACCAAGAGCCACAGGATCTC TTTGCAGGGGATGGTATGAATGCATATGTAGCCTACAAAGTTACAACACAGACAAGCTTACCATTGTTCAGAAGCAAACAGTTTGCAGTAAAAAGAAGAT TTAGTGACTTTCTGGGTCTTTATGAGAAGCTTTCCGAGAAGCACTCTCAGAATGGCTTCATTGTCCCTCCGCCCCCGGAGAAGAGCCTCATAGGGATGAC AAAAGTGAAAGTTGGGAAGGAAGATTCTTCTTCTGCAGAATTTCTTGAAAAACGGAGGGCCGCTTTAGAAAGGTACCTTCAGAGGATTGTAAATCATCCT ACCATGTTACAGGACCCTGACGTCAGAGAGTTCTTGGAAAAAGAAGAGCTGCCACGTGCCGTGGGTACCCAGACATTGAGTGGTGCTGGTCTCCTCAAGA TGTTCAACAAAGCCACAGATGCCGTCAGCAAAATGACCATCAAGATGAATGAATCAGACATTTGGTTTGAGGAGAAGCTCCAGGAGGTAGAGTGTGAGGA GCAGCGCTTACGGAAACTGCATGCTGTTGTAGAAACTCTAGTCAACCATAGGAAAGAGCTAGCGCTGAACACAGCCCAGTTTGCAAAGAGTCTAGCCATG CTTGGGAGCTCTGAGGACAACACGGCATTGTCACGGGCACTCTCCCAGCTGGCTGAGGTGGAAGAAAAAATTGAGCAGCTCCACCAGGAACAGGCCAACA ATGACTTCTTCCTCCTTGCTGAGCTCCTGAGTGACTACATTCGCCTCCTGGCCATAGTCCGCGCTGCCTTCGACCAGCGCATGAAGACATGGCAGCGCTG GCAGGATGCCCAAGCCACACTGCAGAAGAAGCGGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATC CTCGAGTGGGAGTCTCGGGTGACTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCA AGGACTTCAAGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGC CATCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGATGCATCCT GCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAGCTTCCATATATATTTTCTTAC CTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGAGTATTGATATAAATATATAAATACAAATGTA TATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGTGCCATGAAAAGGTTATGTAATAAAATATTTTAAAATCAGGTC ACATGACTCAGAATGTTGGTGGTTTTTGCTTAGGCTGGGGAGCAGTTGGGAATCAGGTCTGGAATACTCCTAACCAAGAAGTTGCCCAGGTATAGTAAGT TTTTCTCTACCGTTCACAAGTTTTGTGCTGCTGCTTCCCTCTGGAAATGGGGTTTCTTTCTCTCCGCCTACCTCAGCTACCTGTTCTGAGGGTCTCAATC TGTTTCGTATTCCCACTTCTTTAGGGAAGGAGTTTTAAAAACATCTCTTAAAATAAGAGGAGCAAAATCTATTAAAACCTATTCTCCTGCAAAGGAGGCA GAGACTTTCTCTCTCTCTTTTTTTTTTTTTTTTGGTGTCCCTATCATTAAGCAAGAGCCTTTCTCTTTTATTCTTCCTGCTTCCCTAAGCTGCTCAGGGT TCTCTGAGTCTTGCCCTCTGATGGCAAGTCTTATATATAACTAAACCTATTTTTGTCACCCATCAAAACACATCCTCAGTAGACTGTGTGAAGGTGTGAA GGTCTGATAATGACTTGATGCTTTGTCTCCATAGACATGAAAGCCATGCCCTCTGCCTCTAGATAGGGTGATCCAAGAGCTCCTGAACCTTAGGAGGTTC AAAGAAGCTCTACTGTCTGTGCCCAGGAGGTAGCCTGCCAGCAAGAGCCCTCAGGAGTTGCACACACAGCCAAAGGGTGTTCACACAGATCTCTGCCGGT CTAGCCAGGGGAGGCCAGAGTCTCGTCAGTCAAGGATGGGCTTCCCCCTTAGCTGTGTCCACAGCTGCTCAAGCTATACTGGTCAGAGTGGGCTTTGAAG CTCCTTTGTGAGCTCGAGCTGCTGACTGCCACTATGGGAGCCTTGCCACCTCCAGCCCCTCCATCCCAAAGACGCTCCTGCCACTGGGGCCCCAGGTCCT GCTGTATCAGTTCTCTTTGGTGGGGGGCTAAGGTTTGGGGCGAGGCAACCTGAGACAAGAAAACGCAGTAAACATTCTGATTCCCTGTACACAGATGCAG CACCAGGGGAAGGGCCAGTGGTGCAAGTATTTCTTTTTAACAGGTGAAGTTTTTGGAAAAAGTCACTCTCCCTACCCCTCAGTATCCTTACCATCAACTT TGGTTTTATCCTTCCAGTCTTTATTATATGCTTGCTTTTACATAGTTGTAATAATATACACATAAAGTATTTTGTATCCTGCTTTTATCATTCAACATTG TACATGTTATAAGCATTTTACTATATTGTTATATATCTTCACAAAGTTGATCTGTAAAGCTGTGTAATTTGAAGGCATCCATAGGGTGACTGTACCATAA TTTTGATTCATCCCTTGTTGTTGGATTCTTGGTCAGGGGTTGTTTGTTTTGTTTTATTGGTAACTTTAAAATTTTGAATACAATTTCAGATTTACAGAAA AGTTGCAGGAATATCACAAAGAACTCCTATATATCTTTTATCCAGATTTACTGAGTGTTTACATTTTATCCCATTTGCCTTATCTATATTTCATGTTGCA TTTTCTTAATCATTTGAGAATAATTTGCACAGATACCCCATTATGCCCAAAACAGTATGCATTTCCCTAAGAACAGGACATTCTCTTCTAAGAGAAGAAG AGAATTACTTTAAGCATTATTCAGTATTTTTTTAAGTATTATTATCAAAATCAGGAAGTTTAACAGTGATTTAATACTGTTATCTAACCCATGATTCATA TTTAAATTTTGCCATTTATCCCAATAATGTCCTTTGTAGCCATTCTTTTACCTTGTGCAGGATCATGTTACATTTGTAAACGTGTGTCTCTCAATACTGC AGATTCCTCAACTTTCTTTTGTCTTTCATTACCATGACATTTTTGAAGAATACAGGCTATTTTGTCGAATGTTCCTCAGTTTGGATTTGTGTGATGGTTC CGCATGACTAGGTGAGGGTTTTGCATTCTGGGTGGGAATATCACAGAAGCAGTGTGTCGTCAGTGCGTCGTAATCAGCATATAATGTCAGTTGGTCCCAT TAATGTTGTTAACTCTGTTCACCGCTTAGGTTGGTGTCTGCCAGATTTCATTTTAAATTTACGATTTCCTCTTTGTAATTTACAAGTAATTTGTGGGGAG ATACTTTGAGACTATATAAGTATTTTGTTCCTCATTCACCAGTTATATAGTATCAGTTGATTAGTCTTGTCCCAGTTATTACTGTCATGATTGACCAACA TGATTTCCTAACTCCATAATGCCTTCTACATTTATTGGTTGACATTCTACATACAAAGAAAAACATCCTTTCTCACCATTTATTTATTCACTTGTTTATC AATATGGATGCAGGGATTCCTGTTTTACTCAGAGTTGCAAGCCATTGCTTTGATTTTATCTTGATTCTCAAATTGTCCCAGATTTATAGCGGCCTCTTGT GTGTTTGTAGCTTGCTCCCATCATGTTTTGAGTACTTTCTTACCTTCTGGCATAACAAGATGTTCCAGGCTCATCTTGAATGTTCCCTACCCTAGCCCTG GAATCAGCCATTTCTCCAGGGAGTCTTGGTTCCTTATAATGGAGAATGGTATTTATTTATTTTTATTTGATTTGATTATTATTACTATTTTTGAGACAGA GTCTCGCTCTTGTCGCCCAGGCTGGATTGCAATGGCACAATCTCAGCTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCTTCC AAGTAGCTGGGATTACAGGTGCCTGCCCCCACACCCAGCTAATTTTTGCATTTTTGGTAGAAATGGGGGTTTTACCATGTTGGGGAGGCTGGTCTCGAAC TCCTGACCTCAGGTGATCTGCCCACCTCAACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATACCCAGCCAGAGAATGTTATTTAGAAACCAAG ATCTGGGTGCCAAATGTGCTGCTTGTTACTGGAATGTCATTGCCTCTAGGCTCTCACCATACAGTGCAAAGAGATGATAGATAGATAGATAGATAGATAG ATAGATAGATAGATAGATGATAGATATAGATAGATAGATAGATTGATTGATTTGTAGAAACAAGATAGGTTAGAGATACCTGACATAAATAGATACTAAA AATCATGAATTCACACTGATGCTTTGAGACCAGCCCTGTAGGTTTATTCCAGTCTGCCCCCTTTTCCATGTTGTTAACTCTTTCCTCCAGAGAGACAAAG ATTTCAGGTTGCTTTGTTAAGTTCCATCTAATGATCATTCTGACGTAAGTCTGTTTTTCTTATTTCCTTGGAATGATGTCTCCTCTGGTTTCAGAACTTC CTCCTCTGCTTCCTGTATCCTGAGGCTGGCGGGGCCAGTTGTCTTTAGGGCTTGTGCATTTTTGTAAAGAGCTTGCACGTGTGGAAATCAAGTAGGCCAG TAGTGGGTTAGGGGTACTGAGCCAGAAGCCTCTACAAGGAATAACAGGAGCACAAAGGAAGAAGGTGGTATTCCAGCTGGGGACCCAGGAGGGAGGACTT TGTGGAGAACCTGATGCTTGAACTGAGTCTAAAAGGTGTAAAAGTGTTTGTTGCTTCTGCCTCCCTGTCTGTCTGGCAGGGTGAGGTAGGCGCATCTAGG GAAATGTCAAGTGGCTTGGTGTAGGGTAAAGTCAGTGAGGCCCATGGAGAAAAACGAGCAGGAGCCACATCACATGGGTGTCTGATAGGACCTGGGAGGC GCTTTCCACATTACCATTGTCGCTTCGTGATCTGGACACACCAGAAGGCGTGAGACTGGAGGCAGGAAGAGCAGCCAGGCTTATCCCTACCCTCAGGAGA GCTGAAAAGGGCAGGTATGGTGGGGCCAGAGCTCAGGAGAGTTTCGGAACCACTGAGATCGGTCCTTGATTTGATGAGAGGCTTGAGGGGAGAGGGAGGT AGCTAGGATGCCCCGCAAGCTTCTGGCCCAGACACTGGGCAGACAATGAAACCCTTTGTAACACATGAGGCAATAGGTTTGGGGCAGATGGGAGGGGAAG CAGTGGTGGGGGCAGTGAGTGCTGAAGGTGTTTTAAGAAGCGGCTCTGGGCCAGGCACAGTGGCTTATGCCTGTATTCCTAGCATTTTGGGAGGCCGAGG TGGGAGAATCACTTGAGCCCAAGAATTTGAGACCAGCCTGGGGAATATAGTGAGACCCTGTCCCTACAAAAATAAAAACAACTAGCTGGGTGTGTGGTGG TGCATGCCTGTAGGCCCAGCTACGCGGGAACATCACCTGAGCCCAGGAGGTTGAGGTTGCAGTGAGCTACAGTTGCGCCACTGCACTCCAGCCTAGGTGA CAGAGCAAGATCTTGTCTCAAAAAAAAAAGCAGCTCTGGATGGGAAGGGAGGCCAGTTGCTTTAAGTAGGGGAGATAGAGTTAAAGGAGGCTTTGTTTTA TTTAAAGGTGGGACAAACTTAAGCATGTTAATAAAATTCAGAGAAGAGAAAGAGAATGACTATCAGAGCCATGTTTGGAAGAAAATGGGGTCCAGAGCAC AGGAAGGGGACCTGTGTTCAGAGGGTGCCTCACTGCTGAGGCCACAGGAAAGAATCTGTAGGTGGAGGGGAGGCCGAAGAGGGGAAGTTTCATGCTTGAT AATTAAAATTTTCTGAGATAGGAATGTCATATTTACCTATTTAAGCCAAGTTTTTTTAGATAAAAGGTATGGAACCTGCTTTCCCCTTGGCTAGTTCAGC GTTTGGGCTCCGGAGTGCTGAAGATGAGGACTGGACTTCGAGCTGGTGTGATCCCAGTATTCAGTGTCAGTACTCAGTGACAAAATAAATGAGAGAAACG GGAATAAGAATTGTCGCCTACACAAAAATACCAGCAACTGTTAACTCTTCCCAGAAGATTTTCATTCTGAATGCTCCTGTAGCTAGGAACCCTAAAAAGT CTTTGAAGCAACTCAAGTTTTAAAAAAGGGGAGGAACTCCTGGAAATCTCAGGATGGGGCCAAGATGTGGCTGGAGAGTGTGTGGTGATGGAGGGCGTGT CTTTTGCCGAGCACACTCAGGGCCCACGGGAAGCCCATAGACTTCAAGGACATCAAGCCCCAAGGTGGTGGGATTTTCCCCACCAGTACTTGGCAGCCTA GGGGGAAGGGGAGGGCGGGAGAAGATAATGGGGATCCCTGGCTCCAAACATAGGAGGACACATCTGTGCTACAGTGCGCACATGCCTGGATGTACACTCT GTCTTTGGAGACACTGGCTAAGATTCTCTGCTCCATGTTTGGACAGGGTCGTGCCTGATCTGAGATAAATGGACAAGAACAACTGAAGCCTGTCTTCTGG TGCATGTGTCACCTGCCGATAACTGCATCTTGTGATAAAGTTGGGTGATTTACAGTCTCCACCAAATGCTAAACTCTGGGGTCTTACGCCTTTATAACTC CATGGGCCCCAGCAAAGGTTCAGGCTCAAAACAGGTGTCAAATAGATAACTGTTGAATGATTGTTCCCCAGTTGCAGGCTCTGCCACCTGGCGTTCATAC TGTCTGTGAAAGGACCCAGCTCACCTTTCCCTCTTTATCTCCCAGTCCTTCCCAACAGCGCCGACACCTCATGGAAACTGATTGCAAATGTGCTACTTCT CACTTCTGTGTGGCCCGAGGAGGCTGGGTTAATGCTGGGCTTGGTACCTTAAGCACCCTTTCTCCCTTCCCCATCTTCATTCTCAGAATTACACCTGTCT GAAGCAGGCATTTTCCAATGCCCTAGATGGGAATATAAGTGTAAGGAGATGTGAAGCATTTGCCTGTGTGTCAGAACATTCACTGAGGATCCTCATAGGC ACTTCTAGAAACCAAATCCTTGAAGATGACTAACCAGAAATGCCCGTCATAGCACTGTTTACAGTTGCAAAAACTGAAGCCAATTGAAATGTCCATCAGG AGGGGATTAAATGAATTATGGTACAGTTACACCGTTGAATATTTTACAGCCATTGAAGATGATATATAGCTATATTCATTGACAAGGAAAACTCATATTT TTTAGTGAAAAAAGCAGGTTATAGAATTGCATGATATTCACATTTATATAAAACTTTATATATGGGAAGGATGTTGATTGAATTGTTAATAACTATGGTC ACCTCTAGAGATGGAAGTTTGCATTACCTTTAATTTTTAATACCATTTTGTATTGCTTAAAATTTGTATGTATTATCGTTAAAATAAGAAAAATCAAATA AAGCTATTTTCATTATGGGAAAACAA

refseq_SNX1.F2 (forward primer)
refseq_SNX1.R2 (reverse primer)
Single exon skipping

Frame 0

SCCCGFRRGWKKMASGGGGCSASERLPPPFPGL EPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSK HQSPKITTSLLPINNGSKENGIHEEQDQEPQDL FAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRR FSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMT KVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP TMLQDPDVREFLEKEELPRAVGTQTLSGAGLLK MFNKATDAVSKMTIKMNESDIWFEEKLQEVECEE QRLRKLHAVVETLVNHRKELALNTAQFAKSLAM LGSSEDNTALSRALSQLAEVEEKIEQLHQEQAN NDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW QDAQATLQKKREAEARLLWANKPDKLQQAKDEI LEWESRVTQYERDFERISTVVRKEVIRFEKEKS KDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKA IS*WTKDPRAHLCDAAFLYTVLLHLDGPLVMHP A*AGLNPFLPVPTTNCPQLL*PLFHLASIYIFL PKRIVSCFKQKTYNRWWNYGMGWSIDINI*IQMY IFQDVV*ELGITFSVTPDGAMKRLCNKIF*NQV T*LRMLVVFA*AGEQLGIRSGILLTKKLPRYSK FFSTVHKFCAAASLWKWGFFLSAYLSYLF*GSQS VSYSHFFREGVLKTSLKIRGAKSIKTYSPAKEA ETFSLSFFFFFGVPIIKQEPFSFILPASLSCSG FSESCPLMASLIYN*TYFCHPSKHILSRLCEGVK V***LDALSP*T*KPCPLPLDRVIQELLNLRRF KEALLSVPRR*PASKSPQELHTQPKGVHTDLCR SSQGRPESRQSRMGFPLSCVHSCSSYTGQSGL*S SFVSSSC*LPLWEPCHLQPLHPKDAPATGAPGP AVSVLFGGGLRFGARQPETRKRSKHSDSLYTDA APGEGPVVQVFLFNR*SFWKKSLSLPLSILTINF GFILPVFIICLLLHSCNNIHIKYFVSCFYHSTL YML*AFYYIVIYLHKVDL*SCVI*RHP*GDCTI ILIHPLLLDSWSGVVCFVLLVTLKF*IQFQIYRK VAGISQRTPIYLLSRFTECLHFIPFALSIFHVA FS*SFENNLHRYPIMPKTVCISLRTGHSLLREE ENYFKHYSVFF*VLLSKSGSLTVI*YCYLTHDSY LNFAIYPNNVLCSHSFTLCRIMLHL*TCVSQYC RFLNFLLSFITMTFLKNTGYFVECSSVWICVMV PHD*VRVLHSGWEYHRSSVSSVRRNQHIMSVGPI NVVNSVHRLGWCLPDFILNLRFPLCNLQVICGE IL*DYISILFLIHQLYSIS*LVLSQLLLS*LTN MIS*LHNAFYIYWLTFYIQRKTSFLTIYLFTCLS IWMQGFLFYSELQAIALILS*FSNCPRFIAASC VFVACSHHVLSTFLPSGITRCSRLILNVPYPSP GISHFSRESWFLIMENGIYLFLFDLIIITIFETE SRSCRPGWIAMAQSQLTATSTYQVQAILLPQPS K*LGLQVPAPTPS*FLHFW*KWGFYHVGEAGLE LLTSGDLPTSTSQSAGITGVSHHTQPENVI*KPR SGCQMCCLLLECHCL*ALTIQCKEMIDR*IDR* IDR*IDDRYR*IDRLIDL*KQDRLEIPDINRY* KS*IHTDALRPAL*VYSSLPPFPCC*LFPPERQR FQVALLSSI**SF*RKSVFLISLE*CLLWFQNF LLCFLYPEAGGASCL*GLCIFVKSLHVWKSSRP VVG*GY*ARSLYKE*QEHKGRRWYSSWGPRREDF VENLMLELSLKGVKVFVASASLSVWQGEVGASR EMSSGLV*GKVSEAHGEKRAGATSHGCLIGPGR RFPHYHCRFVIWTHQKA*DWRQEEQPGLSLPSGE LKRAGMVGPELRRVSEPLRSVLDLMRGLRGEGG S*DAPQASGPDTGQTMKPFVTHEAIGLGQMGGE AVVGAVSAEGVLRSGSGPGTVAYACIPSILGGRG GRIT*AQEFETSLGNIVRPCPYKNKNN*LGVWW CMPVGPATREHHLSPGG*GCSELQLRHCTPA*V TEQDLVSKKKAALDGKGGQLL*VGEIELKEALFY LKVGQT*AC**NSEKRKRMTIRAMFGRKWGPEH RKGTCVQRVPHC*GHRKESVGGGEAEEGKFHA* *LKFSEIGMSYLPI*AKFF*IKGMEPAFPLASSA FGLRSAEDEDWTSSWCDPSIQCQYSVTK*MRET GIRIVAYTKIPATVNSSQKIFILNAPVARNPKK SLKQLKF*KRGGTPGNLRMGPRCGWRVCGDGGRV FCRAHSGPTGSP*TSRTSSPKVVGFSPPVLGSL GGRGGREKIMGIPGSKHRRTHLCYSAHMPGCTL CLWRHWLRFSAPCLDRVVPDLR*MDKNN*SLSSG ACVTCR*LHLVIKLGDLQSPPNAKLWGLTPL*L HGPQQRFRLKTGVK*ITVE*LFPSCRLCHLAFI LSVKGPSSPFPLYLPVLPNSADTSWKLIANVLLL TSVWPEEAGLMLGLVP*APFLPSPSSFSELHLS EAGIFQCPRWEYKCKEM*SICLCVRTFTEDPHR HF*KPNP*R*LTRNARHSTVYSCKN*SQLKCPSG GD*MNYGTVTPLNILQPLKMIYSYIH*QGKLIF FSEKSRL*NCMIFTFI*NFIYGKDVD*IVNNYG HL*RWKFALPLIFNTILYCLKFVCIIVKIRKIK* SYFHYGKT

Frame 1

VVVAASAAGGRRWRRVVVAVALRRDCLRPSPAW SRSPRGRPGDQNPRLGTATPRGRTFSPAPRWSV NISLQR*LHPFFPSTMAPKKMGSMKNKTKSHRIS LQGMV*MHM*PTKLQHRQAYHCSEANSLQ*KED LVTFWVFMRSFPRSTLRMASLSLRPRRRAS*G* QK*KLGRKILLLQNFLKNGGPL*KGTFRGL*IIL PCYRTLTSESSWKKKSCHVPWVPRH*VVLVSSR CSTKPQMPSAK*PSR*MNQTFGLRRSSRR*SVR SSAYGNCMLL*KL*STIGKS*R*TQPSLQRV*PC LGALRTTRHCHGHSPSWLRWKKKLSSSTRNRPT MTSSSLLSS*VTTFASWP*SALPSTSA*RHGSA GRMPKPHCRRSGRPRLGCCGPTSLISCSRPRTRS SSGSLG*LNMKGTSRGFQQWSEKK*YGLRKRNP RTSRTT*SSTLRHSFTHSSSWQSTGKPSFLRQR PSPNGPRTPEPTCVTLPFYTLSSSTLMDP**CIL PRLDLTPSSLSPRPTVPSYSNRYFI*LPYIFSY LRE*FPALSKRPTIGGGIMGWGGVLI*IYKYKC IFFRMWFRNWE*RFLLLLMVP*KGYVIKYFKIRS HDSECWWFLLRLGSSWESGLEYS*PRSCPGIVS FSLPFTSFVLLLPSGNGVSFSPPTSATCSEGLN LFRIPTSLGKEF*KHLLK*EEQNLLKPILLQRRQ RLSLSLFFFFLVSLSLSKSLSLLFFLLP*AAQG SLSLAL*WQVLYITKPIFVTHQNTSSVDCVKV* RSDNDLMLCLHRHESHALCL*IG*SKSS*TLGGS KKLYCLCPGGSLPARALRSCTHSQRVFTQISAG LARGGQSLVSQGWASPLAVSTAAQAILVRVGFE APL*ARAADCHYGSLATSSPSIPKTLLPLGPQVL LYQFSLVGG*GLGRGNLRQENAVNILIPCTQMQ HQGKGQWCKYFFLTGEVFGKSHSPYPSVSLPST LVLSFQSLLYACFYIVVIIYT*SILYPAFIIQHC TCYKHFTILLYIFTKLICKAV*FEGIHRVTVP* F*FIPCCWILGQGLFVLFYW*L*NFEYNFRFTE KLQEYHKELLYIFYPDLLSVYILSHLPYLYFMLH FLNHLRIICTDTPLCPKQYAFP*EQDILF*EKK RITLSIIQYFFKYYYQNQEV*Q*FNTVI*PMIH I*ILPFIPIMSFVAILLPCAGSCYICKRVSLNTA DSSTFFCLSLP*HF*RIQAILSNVPQFGFV*WF RMTR*GFCILGGNITEAVCRQCVVISI*CQLVP LMLLTLFTA*VGVCQISF*IYDFLFVIYK*FVGR YFETI*VFCSSFTSYIVSVD*SCPSYYCHD*PT *FPNSIMPSTFIG*HSTYKEKHPFSPFIYSLVY QYGCRDSCFTQSCKPLL*FYLDSQIVPDL*RPLV CL*LAPIMF*VLSYLLA*QDVPGSS*MFPTLAL ESAISPGSLGSL*WRMVFIYFYLI*LLLLFLRQ SLALVAQAGLQWHNLSSLQPPPTRFKQFSCLSLP SSWDYRCLPPHPANFCIFGRNGGFTMLGRLVSN S*PQVICPPQPPKVLGLQV*ATIPSQRMLFRNQ DLGAKCAACYWNVIASRLSPYSAKR**IDR*IDR *IDR*MIDIDR*ID*LICRNKIG*RYLT*IDTK NHEFTLML*DQPCRFIPVCPLFHVVNSFLQRDK DFRLLC*VPSNDHSDVSLFFLFPWNDVSSGFRTS SSASCILRLAGPVVFRACAFL*RACTCGNQVGQ *WVRGTEPEASTRNNRSTKEEGGIPAGDPGGRT LWRT*CLN*V*KV*KCLLLLPPCLSGRVR*AHLG KCQVAWCRVKSVRPMEKNEQEPHHMGV**DLGG AFHITIVAS*SGHTRRRETGGRKSSQAYPYPQE S*KGQVWWGQSSGEFRNH*DRSLI**EA*GEREV ARMPRKLLAQTLGRQ*NPL*HMRQ*VWGRWEGK QWWGQ*VLKVF*EAALGQAQWLMPVFLAFWEAE VGESLEPKNLRPAWGI**DPVPTKIKTTSWVCGG ACL*AQLRGNIT*AQEVEVAVSYSCATALQPR* QSKILSQKKKQLWMGREASCFK*GR*S*RRLCF I*RWDKLKHVNKIQRRERE*LSEPCLEENGVQST GRGPVFRGCLTAEATGKNL*VEGRPKRGSFMLD N*NFLR*ECHIYLFKPSFFR*KVWNLLSPWLVQ RLGSGVLKMRTGLRAGVIPVFSVSTQ*QNK*EKR E*ELSPTQKYQQLLTLPRRFSF*MLL*LGTLKS L*SNSSFKKGEELLEISGWGQDVAGECVVMEGV SFAEHTQGPREAHRLQGHQAPRWWDFPHQYLAA* GEGEGGRR*WGSLAPNIGGHICATVRTCLDVHS VFGDTG*DSLLHVWTGSCLI*DKWTRTTEACLL VHVSPADNCIL**SWVIYSLHQMLNSGVLRLYNS MGPSKGSGSKQVSNR*LLNDCSPVAGSATWRSY CL*KDPAHLSLFISQSFPTAPTPHGN*LQMCYF SLLCGPRRLG*CWAWYLKHPFSLPHLHSQNYTCL KQAFSNALDGNISVRRCEAFACVSEHSLRILIG TSRNQILEDD*PEMPVIALFTVAKTEAN*NVHQ EGIK*IMVQLHR*IFYSH*R*YIAIFIDKENSYF LVKKAGYRIA*YSHLYKTLYMGRMLIELLITMV TSRDGSLHYL*FLIPFCIA*NLYVLSLK*EKSN KAIFIMGKQ

Frame 2

LLLRLPPRVEEDGVGWWWL*RFGETASALPRPG AGVRGGGRGIRTRGWGQRHRGGGHFHRRRGGQ* TSVSKDNYIPSSHQQWLQRKWDP*RTRPRATGS LCRGWYECICSLQSYNTDKLTIVQKQTVCSKKKI **LSGSL*EAFREALSEWLHCPSAPGEEPHRDD KSESWEGRFFFCRIS*KTEGRFRKVPSEDCKSS YHVTGP*RQRVLGKRRAATCRGYPDIEWCWSPQD VQQSHRCRQQNDHQDE*IRHLV*GEAPGGRV*G AALTETACCCRNSSQP*ERASAEHSPVCKESSH AWEL*GQHGIVTGTLPAG*GGRKN*AAPPGTGQQ *LLPPC*APE*LHSPPGHSPRCLRPAHEDMAAL AGCPSHTAEEAGGRGSAAVGQQA**AAAGQGRD PRVGVSGDSI*KGLREDFNSGPKRSDTV*EREIQ GLQEPRDQVP*DTPLLTAAAGKVLGSLPS*GKG HLLMDQGPQSPPV*RCLFIHCPPPP*WTPSDAS CLGWT*PLPPCPHDQLSPVTLTVISFSFHIYFLT *ENSFLL*AKDLQ*VVELWDGVEY*YKYINTNV YFSGCGLGTGNNVFCYS*WCHEKVM**NILKSG HMTQNVGGFCLGWGAVGNQVWNTPNQEVAQV**V FLYRSQVLCCCFPLEMGFLSLRLPQLPVLRVSI CFVFPLL*GRSFKNIS*NKRSKIY*NLFSCKGG RDFLSLFFFFFWCPYH*ARAFLFYSSCFPKLLRV L*VLPSDGKSYI*LNLFLSPIKTHPQ*TV*RCE GLIMT*CFVSIDMKAMPSASR*GDPRAPEP*EV QRSSTVCAQEVACQQEPSGVAHTAKGCSHRSLPV *PGEARVSSVKDGLPP*LCPQLLKLYWSEWALK LLCELELLTATMGALPPPAPPSQRRSCHWGPRS CCISSLWWGAKVWGEAT*DKKTQ*TF*FPVHRCS TRGRASGASISF*QVKFLEKVTLPTPQYPYHQL WFYPSSLYYMLAFT*L**YTHKVFCILLLSFNI VHVISILLYCYISSQS*SVKLCNLKASIG*LYHN FDSSLVVGFLVRGCLFCFIGNFKILNTISDLQK SCRNITKNSYISFIQIY*VFTFYPICLIYISCC IFLII*E*FAQIPHYAQNSMHFPKNRTFSSKRRR ELL*ALFSIFLSIIIKIRKFNSDLILLSNP*FI FKFCHLSQ*CPL*PFFYLVQDHVTFVNVCLSIL QIPQLSFVFHYHDIFEEYRLFCRMFLSLDLCDGS A*LGEGFAFWVGISQKQCVVSAS*SAYNVSWSH *CC*LCSPLRLVSARFHFKFTISSL*FTSNLWG DTLRLYKYFVPHSPVI*YQLISLVPVITVMIDQH DFLTP*CLLHLLVDILHTKKNILSHHLFIHLFI NMDAGIPVLLRVASHCFDFILILKLSQIYSGLL CVCSLLPSCFEYFLTFWHNKMFQAHLECSLP*PW NQPFLQGVLVPYNGEWYLFIFI*FDYYYYF*DR VSLLSPRLDCNGTISAHCNLHLPGSSNSPASAF QVAGITGACPHTQLIFAFLVEMGVLPCWGGWSRT PDLR*SAHLNLPKCWDYRCEPPYPARECYLETK IWVPNVLLVTGMSLPLGSHHTVQRDDR*IDR*I DR*IDR**I*IDR*ID*FVETR*VRDT*HK*ILK IMNSH*CFETSPVGLFQSAPFSMLLTLSSRETK ISGCFVKFHLMIILT*VCFSYFLGMMSPLVSEL PPLLPVS*GWRGQLSLGLVHFCKELARVEIK*AS SGLGVLSQKPLQGITGAQRKKVVFQLGTQEGGL CGEPDA*TESKRCKSVCCFCLPVCLAG*GRRI* GNVKWLGVG*SQ*GPWRKTSRSHITWVSDRTWEA LSTLPLSLRDLDTPEGVRLEAGRAARLIPTLRR AEKGRYGGARAQESFGTTEIGP*FDERLEGRGR *LGCPASFWPRHWADNETLCNT*GNRFGADGRGS SGGGSEC*RCFKKRLWARHSGLCLYS*HFGRPR WENHLSPRI*DQPGEYSETLSLQK*KQLAGCVV VHACRPSYAGTSPEPRRLRLQ*ATVAPLHSSLGD RARSCLKKKSSSGWEGRPVALSRGDRVKGGFVL FKGGTNLSMLIKFREEKENDYQSHVWKKMGSRA QEGDLCSEGASLLRPQERICRWRGGRRGEVSCLI IKIF*DRNVIFTYLSQVFLDKRYGTCFPLG*FS VWAPEC*R*GLDFELV*SQYSVSVLSDKINERN GNKNCRLHKNTSNC*LFPEDFHSECSCS*EP*KV FEATQVLKKGRNSWKSQDGAKMWLESVW*WRAC LLPSTLRAHGKPIDFKDIKPQGGGIFPTSTWQP RGKGRAGEDNGDPWLQT*EDTSVLQCAHAWMYTL SLETLAKILCSMFGQGRA*SEINGQEQLKPVFW CMCHLPITASCDKVG*FTVSTKC*TLGSYAFIT PWAPAKVQAQNRCQIDNC*MIVPQLQALPPGVHT VCERTQLTFPSLSPSPSQQRRHLMETDCKCATS HFCVARGGWVNAGLGTLSTLSPFPIFILRITPV *SRHFPMP*MGI*V*GDVKHLPVCQNIH*GSS*A LLETKSLKMTNQKCPS*HCLQLQKLKPIEMSIR RGLNELWYSYTVEYFTAIEDDI*LYSLTRKTHI F**KKQVIELHDIHIYIKLYIWEGC*LNC**LWS PLEMEVCITFNF*YHFVLLKICMYYR*NKKNQI KLFSLWEN

Sequence NM_003099

AGTTGTTGTTGCGGCTTCCGCCGCGGGTGGAAGAAGATGGCGTCGGGTGGTGGTGGCTGTAGCGCTTCGGAGAGACTGCCTCCGCCCTTCCCCGGCCTGG AGCCGGAGTCCGAGGGGGCGGCCGGGGGATCAGAACCCGAGGCTGGGGACAGCGACACCGAGGGGGAGGACATTTTCACCGGCGCCGCGGTGGTCAGTAA ACATCAGTCTCCAAAGATAACTACATCCCTTCTTCCCATCAACAATGGCTCCAAAGAAAATGGGATCCATGAAGAACAAGACCAAGAGCCACAGGATCTC TTTGCAGATGCCACAGTGGAGCTATCCTTGGACAGCACACAAAATAATCAGAAGAAGGTGCTAGCCAAAACACTCATTTCTCTTCCTCCTCAGGAAGCCA CAAATTCTTCGAAGCCCCAGCCAACCTATGAGGAGCTAGAGGAAGAAGAACAGGAGGATCAATTTGATTTGACAGTCGGTATAACTGATCCTGAGAAGAT AGGGGATGGTATGAATGCATATGTAGCCTACAAAGTTACAACACAGACAAGCTTACCATTGTTCAGAAGCAAACAGTTTGCAGTAAAAAGAAGATTTAGT GACTTTCTGGGTCTTTATGAGAAGCTTTCCGAGAAGCACTCTCAGAATGGCTTCATTGTCCCTCCGCCCCCGGAGAAGAGCCTCATAGGGATGACAAAAG TGAAAGTTGGGAAGGAAGATTCTTCTTCTGCAGAATTTCTTGAAAAACGGAGGGCCGCTTTAGAAAGGTACCTTCAGAGGATTGTAAATCATCCTACCAT GTTACAGGACCCTGACGTCAGAGAGTTCTTGGAAAAAGAAGAGCTGCCACGTGCCGTGGGTACCCAGACATTGAGTGGTGCTGGTCTCCTCAAGATGTTC AACAAAGCCACAGATGCCGTCAGCAAAATGACCATCAAGATGAATGAATCAGACATTTGGTTTGAGGAGAAGCTCCAGGAGGTAGAGTGTGAGGAGCAGC GCTTACGGAAACTGCATGCTGTTGTAGAAACTCTAGTCAACCATAGGAAAGAGCTAGCGCTGAACACAGCCCAGTTTGCAAAGAGTCTAGCCATGCTTGG GAGCTCTGAGGACAACACGGCATTGTCACGGGCACTCTCCCAGCTGGCTGAGGTGGAAGAAAAAATTGAGCAGCTCCACCAGGAACAGGCCAACAATGAC TTCTTCCTCCTTGCTGAGCTCCTGAGTGACTACATTCGCCTCCTGGCCATAGTCCGCGCTGCCTTCGACCAGCGCATGAAGACATGGCAGCGCTGGCAGG ATGCCCAAGCCACACTGCAGAAGAAGCGGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATCCTCGA GTGGGAGTCTCGGGTGACTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGAC TTCAAGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGCCATCT CCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGATGCATCCTGCCTA GGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAGCTTCCATATATATTTTCTTACCTAAG AGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGAGTATTGATATAAATATATAAATACAAATGTATATTT TTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGTGCCATGAAAAGGTTATGTAATAAAATATTTTAAAATCAGGTCACATG ACTCAGAATGTTGGTGGTTTTTGCTTAGGCTGGGGAGCAGTTGGGAATCAGGTCTGGAATACTCCTAACCAAGAAGTTGCCCAGGTATAGTAAGTTTTTC TCTACCGTTCACAAGTTTTGTGCTGCTGCTTCCCTCTGGAAATGGGGTTTCTTTCTCTCCGCCTACCTCAGCTACCTGTTCTGAGGGTCTCAATCTGTTT CGTATTCCCACTTCTTTAGGGAAGGAGTTTTAAAAACATCTCTTAAAATAAGAGGAGCAAAATCTATTAAAACCTATTCTCCTGCAAAGGAGGCAGAGAC TTTCTCTCTCTCTTTTTTTTTTTTTTTTGGTGTCCCTATCATTAAGCAAGAGCCTTTCTCTTTTATTCTTCCTGCTTCCCTAAGCTGCTCAGGGTTCTCT GAGTCTTGCCCTCTGATGGCAAGTCTTATATATAACTAAACCTATTTTTGTCACCCATCAAAACACATCCTCAGTAGACTGTGTGAAGGTGTGAAGGTCT GATAATGACTTGATGCTTTGTCTCCATAGACATGAAAGCCATGCCCTCTGCCTCTAGATAGGGTGATCCAAGAGCTCCTGAACCTTAGGAGGTTCAAAGA AGCTCTACTGTCTGTGCCCAGGAGGTAGCCTGCCAGCAAGAGCCCTCAGGAGTTGCACACACAGCCAAAGGGTGTTCACACAGATCTCTGCCGGTCTAGC CAGGGGAGGCCAGAGTCTCGTCAGTCAAGGATGGGCTTCCCCCTTAGCTGTGTCCACAGCTGCTCAAGCTATACTGGTCAGAGTGGGCTTTGAAGCTCCT TTGTGAGCTCGAGCTGCTGACTGCCACTATGGGAGCCTTGCCACCTCCAGCCCCTCCATCCCAAAGACGCTCCTGCCACTGGGGCCCCAGGTCCTGCTGT ATCAGTTCTCTTTGGTGGGGGGCTAAGGTTTGGGGCGAGGCAACCTGAGACAAGAAAACGCAGTAAACATTCTGATTCCCTGTACACAGATGCAGCACCA GGGGAAGGGCCAGTGGTGCAAGTATTTCTTTTTAACAGGTGAAGTTTTTGGAAAAAGTCACTCTCCCTACCCCTCAGTATCCTTACCATCAACTTTGGTT TTATCCTTCCAGTCTTTATTATATGCTTGCTTTTACATAGTTGTAATAATATACACATAAAGTATTTTGTATCCTGCTTTTATCATTCAACATTGTACAT GTTATAAGCATTTTACTATATTGTTATATATCTTCACAAAGTTGATCTGTAAAGCTGTGTAATTTGAAGGCATCCATAGGGTGACTGTACCATAATTTTG ATTCATCCCTTGTTGTTGGATTCTTGGTCAGGGGTTGTTTGTTTTGTTTTATTGGTAACTTTAAAATTTTGAATACAATTTCAGATTTACAGAAAAGTTG CAGGAATATCACAAAGAACTCCTATATATCTTTTATCCAGATTTACTGAGTGTTTACATTTTATCCCATTTGCCTTATCTATATTTCATGTTGCATTTTC TTAATCATTTGAGAATAATTTGCACAGATACCCCATTATGCCCAAAACAGTATGCATTTCCCTAAGAACAGGACATTCTCTTCTAAGAGAAGAAGAGAAT TACTTTAAGCATTATTCAGTATTTTTTTAAGTATTATTATCAAAATCAGGAAGTTTAACAGTGATTTAATACTGTTATCTAACCCATGATTCATATTTAA ATTTTGCCATTTATCCCAATAATGTCCTTTGTAGCCATTCTTTTACCTTGTGCAGGATCATGTTACATTTGTAAACGTGTGTCTCTCAATACTGCAGATT CCTCAACTTTCTTTTGTCTTTCATTACCATGACATTTTTGAAGAATACAGGCTATTTTGTCGAATGTTCCTCAGTTTGGATTTGTGTGATGGTTCCGCAT GACTAGGTGAGGGTTTTGCATTCTGGGTGGGAATATCACAGAAGCAGTGTGTCGTCAGTGCGTCGTAATCAGCATATAATGTCAGTTGGTCCCATTAATG TTGTTAACTCTGTTCACCGCTTAGGTTGGTGTCTGCCAGATTTCATTTTAAATTTACGATTTCCTCTTTGTAATTTACAAGTAATTTGTGGGGAGATACT TTGAGACTATATAAGTATTTTGTTCCTCATTCACCAGTTATATAGTATCAGTTGATTAGTCTTGTCCCAGTTATTACTGTCATGATTGACCAACATGATT TCCTAACTCCATAATGCCTTCTACATTTATTGGTTGACATTCTACATACAAAGAAAAACATCCTTTCTCACCATTTATTTATTCACTTGTTTATCAATAT GGATGCAGGGATTCCTGTTTTACTCAGAGTTGCAAGCCATTGCTTTGATTTTATCTTGATTCTCAAATTGTCCCAGATTTATAGCGGCCTCTTGTGTGTT TGTAGCTTGCTCCCATCATGTTTTGAGTACTTTCTTACCTTCTGGCATAACAAGATGTTCCAGGCTCATCTTGAATGTTCCCTACCCTAGCCCTGGAATC AGCCATTTCTCCAGGGAGTCTTGGTTCCTTATAATGGAGAATGGTATTTATTTATTTTTATTTGATTTGATTATTATTACTATTTTTGAGACAGAGTCTC GCTCTTGTCGCCCAGGCTGGATTGCAATGGCACAATCTCAGCTCACTGCAACCTCCACCTACCAGGTTCAAGCAATTCTCCTGCCTCAGCCTTCCAAGTA GCTGGGATTACAGGTGCCTGCCCCCACACCCAGCTAATTTTTGCATTTTTGGTAGAAATGGGGGTTTTACCATGTTGGGGAGGCTGGTCTCGAACTCCTG ACCTCAGGTGATCTGCCCACCTCAACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATACCCAGCCAGAGAATGTTATTTAGAAACCAAGATCTG GGTGCCAAATGTGCTGCTTGTTACTGGAATGTCATTGCCTCTAGGCTCTCACCATACAGTGCAAAGAGATGATAGATAGATAGATAGATAGATAGATAGA TAGATAGATAGATGATAGATATAGATAGATAGATAGATTGATTGATTTGTAGAAACAAGATAGGTTAGAGATACCTGACATAAATAGATACTAAAAATCA TGAATTCACACTGATGCTTTGAGACCAGCCCTGTAGGTTTATTCCAGTCTGCCCCCTTTTCCATGTTGTTAACTCTTTCCTCCAGAGAGACAAAGATTTC AGGTTGCTTTGTTAAGTTCCATCTAATGATCATTCTGACGTAAGTCTGTTTTTCTTATTTCCTTGGAATGATGTCTCCTCTGGTTTCAGAACTTCCTCCT CTGCTTCCTGTATCCTGAGGCTGGCGGGGCCAGTTGTCTTTAGGGCTTGTGCATTTTTGTAAAGAGCTTGCACGTGTGGAAATCAAGTAGGCCAGTAGTG GGTTAGGGGTACTGAGCCAGAAGCCTCTACAAGGAATAACAGGAGCACAAAGGAAGAAGGTGGTATTCCAGCTGGGGACCCAGGAGGGAGGACTTTGTGG AGAACCTGATGCTTGAACTGAGTCTAAAAGGTGTAAAAGTGTTTGTTGCTTCTGCCTCCCTGTCTGTCTGGCAGGGTGAGGTAGGCGCATCTAGGGAAAT GTCAAGTGGCTTGGTGTAGGGTAAAGTCAGTGAGGCCCATGGAGAAAAACGAGCAGGAGCCACATCACATGGGTGTCTGATAGGACCTGGGAGGCGCTTT CCACATTACCATTGTCGCTTCGTGATCTGGACACACCAGAAGGCGTGAGACTGGAGGCAGGAAGAGCAGCCAGGCTTATCCCTACCCTCAGGAGAGCTGA AAAGGGCAGGTATGGTGGGGCCAGAGCTCAGGAGAGTTTCGGAACCACTGAGATCGGTCCTTGATTTGATGAGAGGCTTGAGGGGAGAGGGAGGTAGCTA GGATGCCCCGCAAGCTTCTGGCCCAGACACTGGGCAGACAATGAAACCCTTTGTAACACATGAGGCAATAGGTTTGGGGCAGATGGGAGGGGAAGCAGTG GTGGGGGCAGTGAGTGCTGAAGGTGTTTTAAGAAGCGGCTCTGGGCCAGGCACAGTGGCTTATGCCTGTATTCCTAGCATTTTGGGAGGCCGAGGTGGGA GAATCACTTGAGCCCAAGAATTTGAGACCAGCCTGGGGAATATAGTGAGACCCTGTCCCTACAAAAATAAAAACAACTAGCTGGGTGTGTGGTGGTGCAT GCCTGTAGGCCCAGCTACGCGGGAACATCACCTGAGCCCAGGAGGTTGAGGTTGCAGTGAGCTACAGTTGCGCCACTGCACTCCAGCCTAGGTGACAGAG CAAGATCTTGTCTCAAAAAAAAAAGCAGCTCTGGATGGGAAGGGAGGCCAGTTGCTTTAAGTAGGGGAGATAGAGTTAAAGGAGGCTTTGTTTTATTTAA AGGTGGGACAAACTTAAGCATGTTAATAAAATTCAGAGAAGAGAAAGAGAATGACTATCAGAGCCATGTTTGGAAGAAAATGGGGTCCAGAGCACAGGAA GGGGACCTGTGTTCAGAGGGTGCCTCACTGCTGAGGCCACAGGAAAGAATCTGTAGGTGGAGGGGAGGCCGAAGAGGGGAAGTTTCATGCTTGATAATTA AAATTTTCTGAGATAGGAATGTCATATTTACCTATTTAAGCCAAGTTTTTTTAGATAAAAGGTATGGAACCTGCTTTCCCCTTGGCTAGTTCAGCGTTTG GGCTCCGGAGTGCTGAAGATGAGGACTGGACTTCGAGCTGGTGTGATCCCAGTATTCAGTGTCAGTACTCAGTGACAAAATAAATGAGAGAAACGGGAAT AAGAATTGTCGCCTACACAAAAATACCAGCAACTGTTAACTCTTCCCAGAAGATTTTCATTCTGAATGCTCCTGTAGCTAGGAACCCTAAAAAGTCTTTG AAGCAACTCAAGTTTTAAAAAAGGGGAGGAACTCCTGGAAATCTCAGGATGGGGCCAAGATGTGGCTGGAGAGTGTGTGGTGATGGAGGGCGTGTCTTTT GCCGAGCACACTCAGGGCCCACGGGAAGCCCATAGACTTCAAGGACATCAAGCCCCAAGGTGGTGGGATTTTCCCCACCAGTACTTGGCAGCCTAGGGGG AAGGGGAGGGCGGGAGAAGATAATGGGGATCCCTGGCTCCAAACATAGGAGGACACATCTGTGCTACAGTGCGCACATGCCTGGATGTACACTCTGTCTT TGGAGACACTGGCTAAGATTCTCTGCTCCATGTTTGGACAGGGTCGTGCCTGATCTGAGATAAATGGACAAGAACAACTGAAGCCTGTCTTCTGGTGCAT GTGTCACCTGCCGATAACTGCATCTTGTGATAAAGTTGGGTGATTTACAGTCTCCACCAAATGCTAAACTCTGGGGTCTTACGCCTTTATAACTCCATGG GCCCCAGCAAAGGTTCAGGCTCAAAACAGGTGTCAAATAGATAACTGTTGAATGATTGTTCCCCAGTTGCAGGCTCTGCCACCTGGCGTTCATACTGTCT GTGAAAGGACCCAGCTCACCTTTCCCTCTTTATCTCCCAGTCCTTCCCAACAGCGCCGACACCTCATGGAAACTGATTGCAAATGTGCTACTTCTCACTT CTGTGTGGCCCGAGGAGGCTGGGTTAATGCTGGGCTTGGTACCTTAAGCACCCTTTCTCCCTTCCCCATCTTCATTCTCAGAATTACACCTGTCTGAAGC AGGCATTTTCCAATGCCCTAGATGGGAATATAAGTGTAAGGAGATGTGAAGCATTTGCCTGTGTGTCAGAACATTCACTGAGGATCCTCATAGGCACTTC TAGAAACCAAATCCTTGAAGATGACTAACCAGAAATGCCCGTCATAGCACTGTTTACAGTTGCAAAAACTGAAGCCAATTGAAATGTCCATCAGGAGGGG ATTAAATGAATTATGGTACAGTTACACCGTTGAATATTTTACAGCCATTGAAGATGATATATAGCTATATTCATTGACAAGGAAAACTCATATTTTTTAG TGAAAAAAGCAGGTTATAGAATTGCATGATATTCACATTTATATAAAACTTTATATATGGGAAGGATGTTGATTGAATTGTTAATAACTATGGTCACCTC TAGAGATGGAAGTTTGCATTACCTTTAATTTTTAATACCATTTTGTATTGCTTAAAATTTGTATGTATTATCGTTAAAATAAGAAAAATCAAATAAAGCT ATTTTCATTATGGGAAAACAA

refseq_SNX1.F2 (forward primer)
refseq_SNX1.R2 (reverse primer)
Single exon skipping

Frame 0

SCCCGFRRGWKKMASGGGGCSASERLPPPFPGL EPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSK HQSPKITTSLLPINNGSKENGIHEEQDQEPQDL FADATVELSLDSTQNNQKKVLAKTLISLPPQEA TNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKI GDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFS DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTM LQDPDVREFLEKEELPRAVGTQTLSGAGLLKMF NKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLG SSEDNTALSRALSQLAEVEEKIEQLHQEQANND FFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQ DAQATLQKKREAEARLLWANKPDKLQQAKDEILE WESRVTQYERDFERISTVVRKEVIRFEKEKSKD FKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAI S*WTKDPRAHLCDAAFLYTVLLHLDGPLVMHPA* AGLNPFLPVPTTNCPQLL*PLFHLASIYIFLPK RIVSCFKQKTYNRWWNYGMGWSIDINI*IQMYI FQDVV*ELGITFSVTPDGAMKRLCNKIF*NQVT* LRMLVVFA*AGEQLGIRSGILLTKKLPRYSKFF STVHKFCAAASLWKWGFFLSAYLSYLF*GSQSV SYSHFFREGVLKTSLKIRGAKSIKTYSPAKEAET FSLSFFFFFGVPIIKQEPFSFILPASLSCSGFS ESCPLMASLIYN*TYFCHPSKHILSRLCEGVKV ***LDALSP*T*KPCPLPLDRVIQELLNLRRFKE ALLSVPRR*PASKSPQELHTQPKGVHTDLCRSS QGRPESRQSRMGFPLSCVHSCSSYTGQSGL*SS FVSSSC*LPLWEPCHLQPLHPKDAPATGAPGPAV SVLFGGGLRFGARQPETRKRSKHSDSLYTDAAP GEGPVVQVFLFNR*SFWKKSLSLPLSILTINFG FILPVFIICLLLHSCNNIHIKYFVSCFYHSTLYM L*AFYYIVIYLHKVDL*SCVI*RHP*GDCTIIL IHPLLLDSWSGVVCFVLLVTLKF*IQFQIYRKV AGISQRTPIYLLSRFTECLHFIPFALSIFHVAFS *SFENNLHRYPIMPKTVCISLRTGHSLLREEEN YFKHYSVFF*VLLSKSGSLTVI*YCYLTHDSYL NFAIYPNNVLCSHSFTLCRIMLHL*TCVSQYCRF LNFLLSFITMTFLKNTGYFVECSSVWICVMVPH D*VRVLHSGWEYHRSSVSSVRRNQHIMSVGPIN VVNSVHRLGWCLPDFILNLRFPLCNLQVICGEIL *DYISILFLIHQLYSIS*LVLSQLLLS*LTNMI S*LHNAFYIYWLTFYIQRKTSFLTIYLFTCLSI WMQGFLFYSELQAIALILS*FSNCPRFIAASCVF VACSHHVLSTFLPSGITRCSRLILNVPYPSPGI SHFSRESWFLIMENGIYLFLFDLIIITIFETES RSCRPGWIAMAQSQLTATSTYQVQAILLPQPSK* LGLQVPAPTPS*FLHFW*KWGFYHVGEAGLELL TSGDLPTSTSQSAGITGVSHHTQPENVI*KPRS GCQMCCLLLECHCL*ALTIQCKEMIDR*IDR*ID R*IDDRYR*IDRLIDL*KQDRLEIPDINRY*KS *IHTDALRPAL*VYSSLPPFPCC*LFPPERQRF QVALLSSI**SF*RKSVFLISLE*CLLWFQNFLL CFLYPEAGGASCL*GLCIFVKSLHVWKSSRPVV G*GY*ARSLYKE*QEHKGRRWYSSWGPRREDFV ENLMLELSLKGVKVFVASASLSVWQGEVGASREM SSGLV*GKVSEAHGEKRAGATSHGCLIGPGRRF PHYHCRFVIWTHQKA*DWRQEEQPGLSLPSGEL KRAGMVGPELRRVSEPLRSVLDLMRGLRGEGGS* DAPQASGPDTGQTMKPFVTHEAIGLGQMGGEAV VGAVSAEGVLRSGSGPGTVAYACIPSILGGRGG RIT*AQEFETSLGNIVRPCPYKNKNN*LGVWWCM PVGPATREHHLSPGG*GCSELQLRHCTPA*VTE QDLVSKKKAALDGKGGQLL*VGEIELKEALFYL KVGQT*AC**NSEKRKRMTIRAMFGRKWGPEHRK GTCVQRVPHC*GHRKESVGGGEAEEGKFHA**L KFSEIGMSYLPI*AKFF*IKGMEPAFPLASSAF GLRSAEDEDWTSSWCDPSIQCQYSVTK*MRETGI RIVAYTKIPATVNSSQKIFILNAPVARNPKKSL KQLKF*KRGGTPGNLRMGPRCGWRVCGDGGRVF CRAHSGPTGSP*TSRTSSPKVVGFSPPVLGSLGG RGGREKIMGIPGSKHRRTHLCYSAHMPGCTLCL WRHWLRFSAPCLDRVVPDLR*MDKNN*SLSSGA CVTCR*LHLVIKLGDLQSPPNAKLWGLTPL*LHG PQQRFRLKTGVK*ITVE*LFPSCRLCHLAFILS VKGPSSPFPLYLPVLPNSADTSWKLIANVLLLT SVWPEEAGLMLGLVP*APFLPSPSSFSELHLSEA GIFQCPRWEYKCKEM*SICLCVRTFTEDPHRHF *KPNP*R*LTRNARHSTVYSCKN*SQLKCPSGG D*MNYGTVTPLNILQPLKMIYSYIH*QGKLIFFS EKSRL*NCMIFTFI*NFIYGKDVD*IVNNYGHL *RWKFALPLIFNTILYCLKFVCIIVKIRKIK*S YFHYGKT

Frame 1

VVVAASAAGGRRWRRVVVAVALRRDCLRPSPAW SRSPRGRPGDQNPRLGTATPRGRTFSPAPRWSV NISLQR*LHPFFPSTMAPKKMGSMKNKTKSHRIS LQMPQWSYPWTAHKIIRRRC*PKHSFLFLLRKP QILRSPSQPMRS*RKKNRRINLI*QSV*LILRR *GMV*MHM*PTKLQHRQAYHCSEANSLQ*KEDLV TFWVFMRSFPRSTLRMASLSLRPRRRAS*G*QK *KLGRKILLLQNFLKNGGPL*KGTFRGL*IILP CYRTLTSESSWKKKSCHVPWVPRH*VVLVSSRCS TKPQMPSAK*PSR*MNQTFGLRRSSRR*SVRSS AYGNCMLL*KL*STIGKS*R*TQPSLQRV*PCL GALRTTRHCHGHSPSWLRWKKKLSSSTRNRPTMT SSSLLSS*VTTFASWP*SALPSTSA*RHGSAGR MPKPHCRRSGRPRLGCCGPTSLISCSRPRTRSS SGSLG*LNMKGTSRGFQQWSEKK*YGLRKRNPRT SRTT*SSTLRHSFTHSSSWQSTGKPSFLRQRPS PNGPRTPEPTCVTLPFYTLSSSTLMDP**CILP RLDLTPSSLSPRPTVPSYSNRYFI*LPYIFSYLR E*FPALSKRPTIGGGIMGWGGVLI*IYKYKCIF FRMWFRNWE*RFLLLLMVP*KGYVIKYFKIRSH DSECWWFLLRLGSSWESGLEYS*PRSCPGIVSFS LPFTSFVLLLPSGNGVSFSPPTSATCSEGLNLF RIPTSLGKEF*KHLLK*EEQNLLKPILLQRRQR LSLSLFFFFLVSLSLSKSLSLLFFLLP*AAQGSL SLAL*WQVLYITKPIFVTHQNTSSVDCVKV*RS DNDLMLCLHRHESHALCL*IG*SKSS*TLGGSK KLYCLCPGGSLPARALRSCTHSQRVFTQISAGLA RGGQSLVSQGWASPLAVSTAAQAILVRVGFEAP L*ARAADCHYGSLATSSPSIPKTLLPLGPQVLL YQFSLVGG*GLGRGNLRQENAVNILIPCTQMQHQ GKGQWCKYFFLTGEVFGKSHSPYPSVSLPSTLV LSFQSLLYACFYIVVIIYT*SILYPAFIIQHCT CYKHFTILLYIFTKLICKAV*FEGIHRVTVP*F* FIPCCWILGQGLFVLFYW*L*NFEYNFRFTEKL QEYHKELLYIFYPDLLSVYILSHLPYLYFMLHF LNHLRIICTDTPLCPKQYAFP*EQDILF*EKKRI TLSIIQYFFKYYYQNQEV*Q*FNTVI*PMIHI* ILPFIPIMSFVAILLPCAGSCYICKRVSLNTAD SSTFFCLSLP*HF*RIQAILSNVPQFGFV*WFRM TR*GFCILGGNITEAVCRQCVVISI*CQLVPLM LLTLFTA*VGVCQISF*IYDFLFVIYK*FVGRY FETI*VFCSSFTSYIVSVD*SCPSYYCHD*PT*F PNSIMPSTFIG*HSTYKEKHPFSPFIYSLVYQY GCRDSCFTQSCKPLL*FYLDSQIVPDL*RPLVC L*LAPIMF*VLSYLLA*QDVPGSS*MFPTLALES AISPGSLGSL*WRMVFIYFYLI*LLLLFLRQSL ALVAQAGLQWHNLSSLQPPPTRFKQFSCLSLPS SWDYRCLPPHPANFCIFGRNGGFTMLGRLVSNS* PQVICPPQPPKVLGLQV*ATIPSQRMLFRNQDL GAKCAACYWNVIASRLSPYSAKR**IDR*IDR* IDR*MIDIDR*ID*LICRNKIG*RYLT*IDTKNH EFTLML*DQPCRFIPVCPLFHVVNSFLQRDKDF RLLC*VPSNDHSDVSLFFLFPWNDVSSGFRTSS SASCILRLAGPVVFRACAFL*RACTCGNQVGQ*W VRGTEPEASTRNNRSTKEEGGIPAGDPGGRTLW RT*CLN*V*KV*KCLLLLPPCLSGRVR*AHLGK CQVAWCRVKSVRPMEKNEQEPHHMGV**DLGGAF HITIVAS*SGHTRRRETGGRKSSQAYPYPQES* KGQVWWGQSSGEFRNH*DRSLI**EA*GEREVA RMPRKLLAQTLGRQ*NPL*HMRQ*VWGRWEGKQW WGQ*VLKVF*EAALGQAQWLMPVFLAFWEAEVG ESLEPKNLRPAWGI**DPVPTKIKTTSWVCGGA CL*AQLRGNIT*AQEVEVAVSYSCATALQPR*QS KILSQKKKQLWMGREASCFK*GR*S*RRLCFI* RWDKLKHVNKIQRRERE*LSEPCLEENGVQSTG RGPVFRGCLTAEATGKNL*VEGRPKRGSFMLDN* NFLR*ECHIYLFKPSFFR*KVWNLLSPWLVQRL GSGVLKMRTGLRAGVIPVFSVSTQ*QNK*EKRE *ELSPTQKYQQLLTLPRRFSF*MLL*LGTLKSL* SNSSFKKGEELLEISGWGQDVAGECVVMEGVSF AEHTQGPREAHRLQGHQAPRWWDFPHQYLAA*G EGEGGRR*WGSLAPNIGGHICATVRTCLDVHSVF GDTG*DSLLHVWTGSCLI*DKWTRTTEACLLVH VSPADNCIL**SWVIYSLHQMLNSGVLRLYNSM GPSKGSGSKQVSNR*LLNDCSPVAGSATWRSYCL *KDPAHLSLFISQSFPTAPTPHGN*LQMCYFSL LCGPRRLG*CWAWYLKHPFSLPHLHSQNYTCLK QAFSNALDGNISVRRCEAFACVSEHSLRILIGTS RNQILEDD*PEMPVIALFTVAKTEAN*NVHQEG IK*IMVQLHR*IFYSH*R*YIAIFIDKENSYFL VKKAGYRIA*YSHLYKTLYMGRMLIELLITMVTS RDGSLHYL*FLIPFCIA*NLYVLSLK*EKSNKA IFIMGKQ

Frame 2

LLLRLPPRVEEDGVGWWWL*RFGETASALPRPG AGVRGGGRGIRTRGWGQRHRGGGHFHRRRGGQ* TSVSKDNYIPSSHQQWLQRKWDP*RTRPRATGS LCRCHSGAILGQHTK*SEEGASQNTHFSSSSGSH KFFEAPANL*GARGRRTGGSI*FDSRYN*S*ED RGWYECICSLQSYNTDKLTIVQKQTVCSKKKI* *LSGSL*EAFREALSEWLHCPSAPGEEPHRDDKS ESWEGRFFFCRIS*KTEGRFRKVPSEDCKSSYH VTGP*RQRVLGKRRAATCRGYPDIEWCWSPQDV QQSHRCRQQNDHQDE*IRHLV*GEAPGGRV*GAA LTETACCCRNSSQP*ERASAEHSPVCKESSHAW EL*GQHGIVTGTLPAG*GGRKN*AAPPGTGQQ* LLPPC*APE*LHSPPGHSPRCLRPAHEDMAALAG CPSHTAEEAGGRGSAAVGQQA**AAAGQGRDPR VGVSGDSI*KGLREDFNSGPKRSDTV*EREIQG LQEPRDQVP*DTPLLTAAAGKVLGSLPS*GKGHL LMDQGPQSPPV*RCLFIHCPPPP*WTPSDASCL GWT*PLPPCPHDQLSPVTLTVISFSFHIYFLT* ENSFLL*AKDLQ*VVELWDGVEY*YKYINTNVYF SGCGLGTGNNVFCYS*WCHEKVM**NILKSGHM TQNVGGFCLGWGAVGNQVWNTPNQEVAQV**VF LYRSQVLCCCFPLEMGFLSLRLPQLPVLRVSICF VFPLL*GRSFKNIS*NKRSKIY*NLFSCKGGRD FLSLFFFFFWCPYH*ARAFLFYSSCFPKLLRVL *VLPSDGKSYI*LNLFLSPIKTHPQ*TV*RCEGL IMT*CFVSIDMKAMPSASR*GDPRAPEP*EVQR SSTVCAQEVACQQEPSGVAHTAKGCSHRSLPV* PGEARVSSVKDGLPP*LCPQLLKLYWSEWALKLL CELELLTATMGALPPPAPPSQRRSCHWGPRSCC ISSLWWGAKVWGEAT*DKKTQ*TF*FPVHRCST RGRASGASISF*QVKFLEKVTLPTPQYPYHQLWF YPSSLYYMLAFT*L**YTHKVFCILLLSFNIVH VISILLYCYISSQS*SVKLCNLKASIG*LYHNF DSSLVVGFLVRGCLFCFIGNFKILNTISDLQKSC RNITKNSYISFIQIY*VFTFYPICLIYISCCIF LII*E*FAQIPHYAQNSMHFPKNRTFSSKRRRE LL*ALFSIFLSIIIKIRKFNSDLILLSNP*FIFK FCHLSQ*CPL*PFFYLVQDHVTFVNVCLSILQI PQLSFVFHYHDIFEEYRLFCRMFLSLDLCDGSA *LGEGFAFWVGISQKQCVVSAS*SAYNVSWSH*C C*LCSPLRLVSARFHFKFTISSL*FTSNLWGDT LRLYKYFVPHSPVI*YQLISLVPVITVMIDQHD FLTP*CLLHLLVDILHTKKNILSHHLFIHLFINM DAGIPVLLRVASHCFDFILILKLSQIYSGLLCV CSLLPSCFEYFLTFWHNKMFQAHLECSLP*PWN QPFLQGVLVPYNGEWYLFIFI*FDYYYYF*DRVS LLSPRLDCNGTISAHCNLHLPGSSNSPASAFQV AGITGACPHTQLIFAFLVEMGVLPCWGGWSRTP DLR*SAHLNLPKCWDYRCEPPYPARECYLETKIW VPNVLLVTGMSLPLGSHHTVQRDDR*IDR*IDR *IDR**I*IDR*ID*FVETR*VRDT*HK*ILKI MNSH*CFETSPVGLFQSAPFSMLLTLSSRETKIS GCFVKFHLMIILT*VCFSYFLGMMSPLVSELPP LLPVS*GWRGQLSLGLVHFCKELARVEIK*ASS GLGVLSQKPLQGITGAQRKKVVFQLGTQEGGLCG EPDA*TESKRCKSVCCFCLPVCLAG*GRRI*GN VKWLGVG*SQ*GPWRKTSRSHITWVSDRTWEAL STLPLSLRDLDTPEGVRLEAGRAARLIPTLRRAE KGRYGGARAQESFGTTEIGP*FDERLEGRGR*L GCPASFWPRHWADNETLCNT*GNRFGADGRGSS GGGSEC*RCFKKRLWARHSGLCLYS*HFGRPRWE NHLSPRI*DQPGEYSETLSLQK*KQLAGCVVVH ACRPSYAGTSPEPRRLRLQ*ATVAPLHSSLGDR ARSCLKKKSSSGWEGRPVALSRGDRVKGGFVLFK GGTNLSMLIKFREEKENDYQSHVWKKMGSRAQE GDLCSEGASLLRPQERICRWRGGRRGEVSCLII KIF*DRNVIFTYLSQVFLDKRYGTCFPLG*FSVW APEC*R*GLDFELV*SQYSVSVLSDKINERNGN KNCRLHKNTSNC*LFPEDFHSECSCS*EP*KVF EATQVLKKGRNSWKSQDGAKMWLESVW*WRACLL PSTLRAHGKPIDFKDIKPQGGGIFPTSTWQPRG KGRAGEDNGDPWLQT*EDTSVLQCAHAWMYTLS LETLAKILCSMFGQGRA*SEINGQEQLKPVFWCM CHLPITASCDKVG*FTVSTKC*TLGSYAFITPW APAKVQAQNRCQIDNC*MIVPQLQALPPGVHTV CERTQLTFPSLSPSPSQQRRHLMETDCKCATSHF CVARGGWVNAGLGTLSTLSPFPIFILRITPV*S RHFPMP*MGI*V*GDVKHLPVCQNIH*GSS*AL LETKSLKMTNQKCPS*HCLQLQKLKPIEMSIRRG LNELWYSYTVEYFTAIEDDI*LYSLTRKTHIF* *KKQVIELHDIHIYIKLYIWEGC*LNC**LWSP LEMEVCITFNF*YHFVLLKICMYYR*NKKNQIKL FSLWEN