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Sequences

Sequence NM_003452

GGAACTGGCAGCGGGGAGGAGGCTCTAGCGAGGCCTGAAAGGCTGCGTAACCAGGCAGGAGTAGGGGTTGGGGTTCGGGGTTGGGGGACAGCCAGGGATC GCGTCTGATATGCTGTTGGGGTCGTGACCGTCTGGGGGCCGAGGCAGGCACTGGCCAGACCCAGCCAGGGATCCTCGTATTCGTCGAGCCTAATTTCCAG CAGCCGGGTAGGCCTCACCAGAGGCTCCTTTCCGTGAGGCCGCCCCCAATTCCTGCCCCTATTCTCTGCCTGGGAGATGGCTTCCCCGAGCCCCCCGCCG GAGTCGAAGGGGTTGCTGACATTTGAGGATGTGGCTGTGTTTTTTACCCAGGAGGAGTGGGATTATCTGGACCCAGCTCAGAGAAGCCTGTATAAAGATG TCATGATGGAGAATTATGGAAACCTGGTCTCACTGGATGTTTTGAACAGAGATAAGGATGAGGAGCCAACTGTAAAACAAGAGATTGAAGAAATTGAGGA AGAAGTGGAACCACAGGGTGTAATAGTTACAAGAATCAAAAGTGAAATTGACCAGGATCCTATGGGTAGAGAAACATTTGAACTTGTTGGTAGGTTAGAT AAACAAAGAGGGATCTTCCTATGGGAAATACCAAGGGAATCTTTGACCCAGGAACAGAGAATGTTCAGAGAAAACACTAACATTATCCGTAAAAGACCAA ACTCAGAAGAGAAATGCCATAAATGTGAAGAATGTGGAAAGGGTTTTGTCCGCAAGGCCCATTTCATTCAACATCAAAGGGTCCATACTGGTGAGAAACC TTTTCAGTGCAATGAATGTGGGAAAAGTTTTAGTCGCAGTTCATTTGTTATTGAACATCAGAGAATTCACACTGGGGAAAGGCCCTATGAGTGTAATTAC TGTGGAAAAACCTTTAGTGTGAGCTCAACCCTTATTAGACATCAGAGAATCCACACTGGAGAAAGACCCTATCAGTGTAATCAGTGTAAACAGAGCTTCA GCCAGAGAAGGAGCCTTGTTAAACATCAAAGGATTCATACAGGTGAGAAACCCCATAAATGTAGTGACTGTGGGAAAGCCTTCAGTTGGAAATCACACCT TATTGAGCATCAAAGAACTCACACTGGTGAGAAACCTTATCACTGTACCAAATGTAAGAAGAGCTTTAGTCGAAATTCATTGCTTGTTGAGCATCAAAGA ATTCACACTGGGGAAAGACCCCATAAATGTGGTGAATGTGGGAAAGCCTTTCGATTAAGCACATACCTTATACAACACCAAAAAATTCACACTGGCGAGA AGCCTTTTCTTTGTATTGAGTGTGGAAAAAGTTTCAGTCGGAGCTCATTCCTTATTGAACATCAGAGGATCCATACTGGTGAAAGACCTTATCAGTGCAA AGAGTGTGGGAAAAGTTTCAGTCAGCTTTGCAACCTTACTCGTCATCAGAGAATTCACACAGGAGACAAGCCCCATAAATGTGAGGAATGTGGAAAAGCC TTTAGTAGAAGCTCAGGTCTTATTCAGCATCAGAGAATTCACACCAGGGAGAAGACTTATCCATACAATGAAACTAAGGAAAGTTTTGATCCAAATTGCA GTCTTGTTATACAGCAGGAAGTCTACCCTAAGGAGAAATCTTATAAATGTGATGAATGTGGGAAAACTTTTAGTGTTAGTGCTCATCTTGTACAACATCA AAGAATCCACACTGGTGAAAAGCCCTATCTATGTACTGTCTGTGGGAAAAGCTTCAGCCGGAGCTCATTTCTTATTGAACATCAGAGAATCCACACTGGT GAGAGACCCTATCTGTGCAGACAGTGTGGAAAAAGCTTTAGTCAGCTTTGTAATCTTATTCGACATCAGGGTGTTCACACAGGTAATAAACCCCATAAAT GTGATGAATGTGGAAAGGCCTTTAGCCGGAACTCGGGTCTTATTCAGCATCAGAGAATACACACAGGAGAGAAACCTTATAAGTGTGAGAAGTGCGACAA AAGTTTCAGTCAACAGCGCAGTCTTGTCAACCATCAGAAGATCCATGCAGAGGTGAAAACCCAAGAAACCCATGAATGTGACGCTTGTGGTGAAGCCTTT AATTGCCGTATTTCTCTTATTCAGCATCAGAAATTGCACACAGCATGGATGCAATAAATGTAGAGCAATACATAAGCTCAATTTGATTTGAGACTAGTAC CCAAGTGCAGTTTTAGTATGGCTCAACATGGGTCAGATTTAGTGATAAAGCAAATTCTCCTTGGCCTCAGGCAAATAGTTTCTAAAGATTCTGTGAATAG TGGACAACTGCCCATGAGCATTTGACTTCCCTTACTCTTTGATGATCGTAGAGAAAGACTTGGTAATTTATCTAAGTATCTTTAATAAATCTTTCAGCAG AGAGATTAAACCTAGGTTCAGAGCATGGGTGCTCTGAGGGACAAAGTTGGATTAGTATAAGGGAGCTGGAGCAGCTGATAGTGGAAAACAGAATAATGAT TCAAAGAGTCTTCTGTCACCATGTCATATTGTGGTTCTTTCAGTTCCATGATATGTTTGGCTCTGCATGCCAAAGTCCAGTGATTAAGCATATATAAGTT GTCAAGGAAACAAAGCCCAAATGTTTTTAAAACAAGTATACAGTTTTTGTCATTGTTTAAGAAAGCCAGTTGTTTGGCATGTGAGTTAAAGGCAGTTCCA ATGCCTGATGGTTCCCAGATCTATGAAATGAGTGGACCATTAACCTTACATGTAAAGATTATGTTAGTAATTAAGAAACCTAACAAAGGTGTTACCAAGG AACCTTTGGGAGTGCCTTTTTTGTTTTTCAAGATGGACCCAAAAAAGTGGAGGAAGATATTGTTCTTTTGTGCCCTCCTACCTGTGAGAGATATTTGTAG TCCTATGTGAATGAGCTTATCCCTCCACAACCAGGTGCATATGAAAGTGTACATATTATGACTGCCAAGTATTGGAAATGAAAAGACCTGGAGTCTATGC TAGGAAGCTGAGATATTTTGGTATTGCATTGGTTTTTATGGTAACTAGGTTTTGCATGCAATTAAAAATCCTTATTTCTTGTTCTAGGGCTTCCCTTAGT TAATGGTTATTATAAACCTATTAATTCATCTGTTTTAACCATTAAAACCTGTTTTGTTTTTAGCTTTG

refseq_ZNF189.F1 (forward primer)
refseq_ZNF189.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

GTGSGEEALARPERLRNQAGVGVGVRGWGTARD RV*YAVGVVTVWGPRQALARPSQGSSYSSSLISS SRVGLTRGSFP*GRPQFLPLFSAWEMASPSPPP ESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKD VMMENYGNLVSLDVLNRDKDEEPTVKQEIEEIEE EVEPQGVIVTRIKSEIDQDPMGRETFELVGRLD KQRGIFLWEIPRESLTQEQRMFRENTNIIRKRP NSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKP FQCNECGKSFSRSSFVIEHQRIHTGERPYECNY CGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSF SQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHL IEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQR IHTGERPHKCGECGKAFRLSTYLIQHQKIHTGE KPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCK ECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKA FSRSSGLIQHQRIHTREKTYPYNETKESFDPNC SLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQ RIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTG ERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHK CDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDK SFSQQRSLVNHQKIHAEVKTQETHECDACGEAF NCRISLIQHQKLHTAWMQ*M*SNT*AQFDLRLV PKCSFSMAQHGSDLVIKQILLGLRQIVSKDSVNS GQLPMSI*LPLLFDDRRERLGNLSKYL**IFQQ RD*T*VQSMGALRDKVGLV*GSWSS**WKTE** FKESSVTMSYCGSFSSMICLALHAKVQ*LSIYKL SRKQSPNVFKTSIQFLSLFKKASCLACELKAVP MPDGSQIYEMSGPLTLHVKIMLVIKKPNKGVTK EPLGVPFLFFKMDPKKWRKILFFCALLPVRDICS PM*MSLSLHNQVHMKVYIL*LPSIGNEKTWSLC *EAEIFWYCIGFYGN*VLHAIKNPYFLF*GFP* LMVIINLLIHLF*PLKPVLFLAL

Frame 1

ELAAGRRL*RGLKGCVTRQE*GLGFGVGGQPGI ASDMLLGS*PSGGRGRHWPDPARDPRIRRA*FP AAG*ASPEAPFREAAPNSCPYSLPGRWLPRAPRR SRRGC*HLRMWLCFLPRRSGIIWTQLREACIKM S*WRIMETWSHWMF*TEIRMRSQL*NKRLKKLR KKWNHRV**LQESKVKLTRILWVEKHLNLLVG*I NKEGSSYGKYQGNL*PRNRECSEKTLTLSVKDQ TQKRNAINVKNVERVLSARPISFNIKGSILVRN LFSAMNVGKVLVAVHLLLNIREFTLGKGPMSVIT VEKPLV*AQPLLDIRESTLEKDPISVISVNRAS AREGALLNIKGFIQVRNPINVVTVGKPSVGNHT LLSIKELTLVRNLITVPNVRRALVEIHCLLSIKE FTLGKDPINVVNVGKPFD*AHTLYNTKKFTLAR SLFFVLSVEKVSVGAHSLLNIRGSILVKDLISA KSVGKVSVSFATLLVIREFTQETSPINVRNVEKP LVEAQVLFSIREFTPGRRLIHTMKLRKVLIQIA VLLYSRKSTLRRNLINVMNVGKLLVLVLILYNI KESTLVKSPIYVLSVGKASAGAHFLLNIRESTLV RDPICADSVEKALVSFVILFDIRVFTQVINPIN VMNVERPLAGTRVLFSIREYTQERNLISVRSAT KVSVNSAVLSTIRRSMQR*KPKKPMNVTLVVKPL IAVFLLFSIRNCTQHGCNKCRAIHKLNLI*D*Y PSAVLVWLNMGQI***SKFSLASGK*FLKIL*I VDNCP*AFDFPYSLMIVEKDLVIYLSIFNKSFSR EIKPRFRAWVL*GTKLD*YKGAGAADSGKQNND SKSLLSPCHIVVLSVP*YVWLCMPKSSD*AYIS CQGNKAQMFLKQVYSFCHCLRKPVVWHVS*RQFQ CLMVPRSMK*VDH*PYM*RLC**LRNLTKVLPR NLWECLFCFSRWTQKSGGRYCSFVPSYL*EIFV VLCE*AYPSTTRCI*KCTYYDCQVLEMKRPGVYA RKLRYFGIALVFMVTRFCMQLKILISCSRASLS *WLL*TY*FICFNH*NLFCF*L

Frame 2

NWQRGGGSSEA*KAA*PGRSRGWGSGLGDSQGS RLICCWGRDRLGAEAGTGQTQPGILVFVEPNFQ QPGRPHQRLLSVRPPPIPAPILCLGDGFPEPPA GVEGVADI*GCGCVFYPGGVGLSGPSSEKPV*RC HDGELWKPGLTGCFEQR*G*GANCKTRD*RN*G RSGTTGCNSYKNQK*N*PGSYG*RNI*TCW*VR *TKRDLPMGNTKGIFDPGTENVQRKH*HYP*KTK LRREMP*M*RMWKGFCPQGPFHSTSKGPYW*ET FSVQ*MWEKF*SQFICY*TSENSHWGKAL*V*L LWKNL*CELNPY*TSENPHWRKTLSV*SV*TELQ PEKEPC*TSKDSYR*ETP*M**LWESLQLEITP Y*ASKNSHW*ETLSLYQM*EEL*SKFIAC*ASK NSHWGKTP*MW*MWESLSIKHIPYTTPKNSHWRE AFSLY*VWKKFQSELIPY*TSEDPYW*KTLSVQ RVWEKFQSALQPYSSSENSHRRQAP*M*GMWKS L**KLRSYSASENSHQGEDLSIQ*N*GKF*SKLQ SCYTAGSLP*GEIL*M**MWENF*C*CSSCTTS KNPHW*KALSMYCLWEKLQPELISY*TSENPHW *ETLSVQTVWKKL*SAL*SYSTSGCSHR**TP*M **MWKGL*PELGSYSASENTHRRETL*V*EVRQ KFQSTAQSCQPSEDPCRGENPRNP*M*RLW*SL *LPYFSYSASEIAHSMDAINVEQYISSI*FETST QVQF*YGSTWVRFSDKANSPWPQANSF*RFCE* WTTAHEHLTSLTL**S*RKTW*FI*VSLINLSA ERLNLGSEHGCSEGQSWISIRELEQLIVENRIMI QRVFCHHVILWFFQFHDMFGSACQSPVIKHI*V VKETKPKCF*NKYTVFVIV*ESQLFGM*VKGSS NA*WFPDL*NEWTINLTCKDYVSN*ET*QRCYQG TFGSAFFVFQDGPKKVEEDIVLLCPPTCERYL* SYVNELIPPQPGAYESVHIMTAKYWK*KDLESM LGS*DILVLHWFLW*LGFACN*KSLFLVLGLPLV NGYYKPINSSVLTIKTCFVFSF

Sequence NM_197977

GGAACTGGCAGCGGGGAGGAGGCTCTAGCGAGGCCTGAAAGGCTGCGTAACCAGGCAGGAGTAGGGGTTGGGGTTCGGGGTTGGGGGACAGCCAGGGATC GCGTCTGATATGCTGTTGGGGTCGTGACCGTCTGGGGGCCGAGGCAGGCACTGGCCAGACCCAGCCAGGGATCCTCGTATTCGTCGAGCCTAATTTCCAG CAGCCGGGTAGGCCTCACCAGAGGCTCCTTTCCGTGAGGCCGCCCCCAATTCCTGCCCCTATTCTCTGCCTGGGAGATGGCTTCCCCGAGCCCCCCGCCG GAGTCGAAGAGAGACTTGATAAATCGGCCTGAGAAAATAAGTAATGCTCCAGACTAGCTCTCTCATTTGTGAGTTCTCCAGGTGAAGCACCATTTTTGAC CTTCCCTTGTGTCTTCTGTTCCTGGCACAGTGCCTGGACCCCAAGGAGGAGTGGGATTATCTGGACCCAGCTCAGAGAAGCCTGTATAAAGATGTCATGA TGGAGAATTATGGAAACCTGGTCTCACTGGATGTTTTGAACAGAGATAAGGATGAGGAGCCAACTGTAAAACAAGAGATTGAAGAAATTGAGGAAGAAGT GGAACCACAGGGTGTAATAGTTACAAGAATCAAAAGTGAAATTGACCAGGATCCTATGGGTAGAGAAACATTTGAACTTGTTGGTAGGTTAGATAAACAA AGAGGGATCTTCCTATGGGAAATACCAAGGGAATCTTTGACCCAGGAACAGAGAATGTTCAGAGAAAACACTAACATTATCCGTAAAAGACCAAACTCAG AAGAGAAATGCCATAAATGTGAAGAATGTGGAAAGGGTTTTGTCCGCAAGGCCCATTTCATTCAACATCAAAGGGTCCATACTGGTGAGAAACCTTTTCA GTGCAATGAATGTGGGAAAAGTTTTAGTCGCAGTTCATTTGTTATTGAACATCAGAGAATTCACACTGGGGAAAGGCCCTATGAGTGTAATTACTGTGGA AAAACCTTTAGTGTGAGCTCAACCCTTATTAGACATCAGAGAATCCACACTGGAGAAAGACCCTATCAGTGTAATCAGTGTAAACAGAGCTTCAGCCAGA GAAGGAGCCTTGTTAAACATCAAAGGATTCATACAGGTGAGAAACCCCATAAATGTAGTGACTGTGGGAAAGCCTTCAGTTGGAAATCACACCTTATTGA GCATCAAAGAACTCACACTGGTGAGAAACCTTATCACTGTACCAAATGTAAGAAGAGCTTTAGTCGAAATTCATTGCTTGTTGAGCATCAAAGAATTCAC ACTGGGGAAAGACCCCATAAATGTGGTGAATGTGGGAAAGCCTTTCGATTAAGCACATACCTTATACAACACCAAAAAATTCACACTGGCGAGAAGCCTT TTCTTTGTATTGAGTGTGGAAAAAGTTTCAGTCGGAGCTCATTCCTTATTGAACATCAGAGGATCCATACTGGTGAAAGACCTTATCAGTGCAAAGAGTG TGGGAAAAGTTTCAGTCAGCTTTGCAACCTTACTCGTCATCAGAGAATTCACACAGGAGACAAGCCCCATAAATGTGAGGAATGTGGAAAAGCCTTTAGT AGAAGCTCAGGTCTTATTCAGCATCAGAGAATTCACACCAGGGAGAAGACTTATCCATACAATGAAACTAAGGAAAGTTTTGATCCAAATTGCAGTCTTG TTATACAGCAGGAAGTCTACCCTAAGGAGAAATCTTATAAATGTGATGAATGTGGGAAAACTTTTAGTGTTAGTGCTCATCTTGTACAACATCAAAGAAT CCACACTGGTGAAAAGCCCTATCTATGTACTGTCTGTGGGAAAAGCTTCAGCCGGAGCTCATTTCTTATTGAACATCAGAGAATCCACACTGGTGAGAGA CCCTATCTGTGCAGACAGTGTGGAAAAAGCTTTAGTCAGCTTTGTAATCTTATTCGACATCAGGGTGTTCACACAGGTAATAAACCCCATAAATGTGATG AATGTGGAAAGGCCTTTAGCCGGAACTCGGGTCTTATTCAGCATCAGAGAATACACACAGGAGAGAAACCTTATAAGTGTGAGAAGTGCGACAAAAGTTT CAGTCAACAGCGCAGTCTTGTCAACCATCAGAAGATCCATGCAGAGGTGAAAACCCAAGAAACCCATGAATGTGACGCTTGTGGTGAAGCCTTTAATTGC CGTATTTCTCTTATTCAGCATCAGAAATTGCACACAGCATGGATGCAATAAATGTAGAGCAATACATAAGCTCAATTTGATTTGAGACTAGTACCCAAGT GCAGTTTTAGTATGGCTCAACATGGGTCAGATTTAGTGATAAAGCAAATTCTCCTTGGCCTCAGGCAAATAGTTTCTAAAGATTCTGTGAATAGTGGACA ACTGCCCATGAGCATTTGACTTCCCTTACTCTTTGATGATCGTAGAGAAAGACTTGGTAATTTATCTAAGTATCTTTAATAAATCTTTCAGCAGAGAGAT TAAACCTAGGTTCAGAGCATGGGTGCTCTGAGGGACAAAGTTGGATTAGTATAAGGGAGCTGGAGCAGCTGATAGTGGAAAACAGAATAATGATTCAAAG AGTCTTCTGTCACCATGTCATATTGTGGTTCTTTCAGTTCCATGATATGTTTGGCTCTGCATGCCAAAGTCCAGTGATTAAGCATATATAAGTTGTCAAG GAAACAAAGCCCAAATGTTTTTAAAACAAGTATACAGTTTTTGTCATTGTTTAAGAAAGCCAGTTGTTTGGCATGTGAGTTAAAGGCAGTTCCAATGCCT GATGGTTCCCAGATCTATGAAATGAGTGGACCATTAACCTTACATGTAAAGATTATGTTAGTAATTAAGAAACCTAACAAAGGTGTTACCAAGGAACCTT TGGGAGTGCCTTTTTTGTTTTTCAAGATGGACCCAAAAAAGTGGAGGAAGATATTGTTCTTTTGTGCCCTCCTACCTGTGAGAGATATTTGTAGTCCTAT GTGAATGAGCTTATCCCTCCACAACCAGGTGCATATGAAAGTGTACATATTATGACTGCCAAGTATTGGAAATGAAAAGACCTGGAGTCTATGCTAGGAA GCTGAGATATTTTGGTATTGCATTGGTTTTTATGGTAACTAGGTTTTGCATGCAATTAAAAATCCTTATTTCTTGTTCTAGGGCTTCCCTTAGTTAATGG TTATTATAAACCTATTAATTCATCTGTTTTAACCATTAAAACCTGTTTTGTTTTTAGCTTTG

refseq_ZNF189.F1 (forward primer)
refseq_ZNF189.R1 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

GTGSGEEALARPERLRNQAGVGVGVRGWGTARD RV*YAVGVVTVWGPRQALARPSQGSSYSSSLISS SRVGLTRGSFP*GRPQFLPLFSAWEMASPSPPP ESKRDLINRPEKISNAPD*LSHL*VLQVKHHF* PSLVSSVPGTVPGPQGGVGLSGPSSEKPV*RCHD GELWKPGLTGCFEQR*G*GANCKTRD*RN*GRS GTTGCNSYKNQK*N*PGSYG*RNI*TCW*VR*T KRDLPMGNTKGIFDPGTENVQRKH*HYP*KTKLR REMP*M*RMWKGFCPQGPFHSTSKGPYW*ETFS VQ*MWEKF*SQFICY*TSENSHWGKAL*V*LLW KNL*CELNPY*TSENPHWRKTLSV*SV*TELQPE KEPC*TSKDSYR*ETP*M**LWESLQLEITPY* ASKNSHW*ETLSLYQM*EEL*SKFIAC*ASKNS HWGKTP*MW*MWESLSIKHIPYTTPKNSHWREAF SLY*VWKKFQSELIPY*TSEDPYW*KTLSVQRV WEKFQSALQPYSSSENSHRRQAP*M*GMWKSL* *KLRSYSASENSHQGEDLSIQ*N*GKF*SKLQSC YTAGSLP*GEIL*M**MWENF*C*CSSCTTSKN PHW*KALSMYCLWEKLQPELISY*TSENPHW*E TLSVQTVWKKL*SAL*SYSTSGCSHR**TP*M** MWKGL*PELGSYSASENTHRRETL*V*EVRQKF QSTAQSCQPSEDPCRGENPRNP*M*RLW*SL*L PYFSYSASEIAHSMDAINVEQYISSI*FETSTQV QF*YGSTWVRFSDKANSPWPQANSF*RFCE*WT TAHEHLTSLTL**S*RKTW*FI*VSLINLSAER LNLGSEHGCSEGQSWISIRELEQLIVENRIMIQR VFCHHVILWFFQFHDMFGSACQSPVIKHI*VVK ETKPKCF*NKYTVFVIV*ESQLFGM*VKGSSNA *WFPDL*NEWTINLTCKDYVSN*ET*QRCYQGTF GSAFFVFQDGPKKVEEDIVLLCPPTCERYL*SY VNELIPPQPGAYESVHIMTAKYWK*KDLESMLG S*DILVLHWFLW*LGFACN*KSLFLVLGLPLVNG YYKPINSSVLTIKTCFVFSF

Frame 1

ELAAGRRL*RGLKGCVTRQE*GLGFGVGGQPGI ASDMLLGS*PSGGRGRHWPDPARDPRIRRA*FP AAG*ASPEAPFREAAPNSCPYSLPGRWLPRAPRR SRRET**IGLRK*VMLQTSSLICEFSR*STIFD LPLCLLFLAQCLDPKEEWDYLDPAQRSLYKDVM MENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEV EPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQ RGIFLWEIPRESLTQEQRMFRENTNIIRKRPNS EEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQ CNECGKSFSRSSFVIEHQRIHTGERPYECNYCG KTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQ RRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIE HQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIH TGERPHKCGECGKAFRLSTYLIQHQKIHTGEKP FLCIECGKSFSRSSFLIEHQRIHTGERPYQCKEC GKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFS RSSGLIQHQRIHTREKTYPYNETKESFDPNCSL VIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRI HTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGER PYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCD ECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSF SQQRSLVNHQKIHAEVKTQETHECDACGEAFNC RISLIQHQKLHTAWMQ*M*SNT*AQFDLRLVPK CSFSMAQHGSDLVIKQILLGLRQIVSKDSVNSGQ LPMSI*LPLLFDDRRERLGNLSKYL**IFQQRD *T*VQSMGALRDKVGLV*GSWSS**WKTE**FK ESSVTMSYCGSFSSMICLALHAKVQ*LSIYKLSR KQSPNVFKTSIQFLSLFKKASCLACELKAVPMP DGSQIYEMSGPLTLHVKIMLVIKKPNKGVTKEP LGVPFLFFKMDPKKWRKILFFCALLPVRDICSPM *MSLSLHNQVHMKVYIL*LPSIGNEKTWSLC*E AEIFWYCIGFYGN*VLHAIKNPYFLF*GFP*LM VIINLLIHLF*PLKPVLFLAL

Frame 2

NWQRGGGSSEA*KAA*PGRSRGWGSGLGDSQGS RLICCWGRDRLGAEAGTGQTQPGILVFVEPNFQ QPGRPHQRLLSVRPPPIPAPILCLGDGFPEPPA GVEERLDKSA*ENK*CSRLALSFVSSPGEAPFLT FPCVFCSWHSAWTPRRSGIIWTQLREACIKMS* WRIMETWSHWMF*TEIRMRSQL*NKRLKKLRKK WNHRV**LQESKVKLTRILWVEKHLNLLVG*INK EGSSYGKYQGNL*PRNRECSEKTLTLSVKDQTQ KRNAINVKNVERVLSARPISFNIKGSILVRNLF SAMNVGKVLVAVHLLLNIREFTLGKGPMSVITVE KPLV*AQPLLDIRESTLEKDPISVISVNRASAR EGALLNIKGFIQVRNPINVVTVGKPSVGNHTLL SIKELTLVRNLITVPNVRRALVEIHCLLSIKEFT LGKDPINVVNVGKPFD*AHTLYNTKKFTLARSL FFVLSVEKVSVGAHSLLNIRGSILVKDLISAKS VGKVSVSFATLLVIREFTQETSPINVRNVEKPLV EAQVLFSIREFTPGRRLIHTMKLRKVLIQIAVL LYSRKSTLRRNLINVMNVGKLLVLVLILYNIKE STLVKSPIYVLSVGKASAGAHFLLNIRESTLVRD PICADSVEKALVSFVILFDIRVFTQVINPINVM NVERPLAGTRVLFSIREYTQERNLISVRSATKV SVNSAVLSTIRRSMQR*KPKKPMNVTLVVKPLIA VFLLFSIRNCTQHGCNKCRAIHKLNLI*D*YPS AVLVWLNMGQI***SKFSLASGK*FLKIL*IVD NCP*AFDFPYSLMIVEKDLVIYLSIFNKSFSREI KPRFRAWVL*GTKLD*YKGAGAADSGKQNNDSK SLLSPCHIVVLSVP*YVWLCMPKSSD*AYISCQ GNKAQMFLKQVYSFCHCLRKPVVWHVS*RQFQCL MVPRSMK*VDH*PYM*RLC**LRNLTKVLPRNL WECLFCFSRWTQKSGGRYCSFVPSYL*EIFVVL CE*AYPSTTRCI*KCTYYDCQVLEMKRPGVYARK LRYFGIALVFMVTRFCMQLKILISCSRASLS*W LL*TY*FICFNH*NLFCF*L