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Sequence NM_000643
CTGTCTACGGCAGCTATTCCAGAGGCAACAACTGCTTCCCTCTGTTCTCATCTCCCCATTGGTGGCTGGCGACCCGAATTTGGGAATGGGGAGATTGCCCACCTGTTATCTTTGAGCAGACTAATCTCTTGGGTAACTCATTCGACTGTGGAGTTCTTTTAATTCTTATGAAAGATTTCAAATCCTCTAGAAGCCAAAAT
GGGACACAGTAAACAGATTCGAATTTTACTTCTGAACGAAATGGAGAAACTGGAAAAGACCCTCTTCAGACTTGAACAAGGGTATGAGCTACAGTTCCGA
TTAGGCCCAACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTTAATAGAGAAAAATTCCGTTCTCTGGATTGGG
AAAATCCAACAGAAAGAGAAGATGATTCTGATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTCAAGGAAATGAGAA
AAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCTGATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAGCT
AAGTGTTTGGGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATGATTCATTTTACCCCATTGCAGACTCTTGGAC
TATCTAGGTCATGCTACTCCCTTGCCAATCAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATGTTGGACAGCTAGT
GGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTCTACAATCATACTGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAATGT
GCCTATAATCTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTCTCCTGTGATGTTGCAGAAGGGAAATACAAAG
AAAAGGGAATACCTGCTTTGATTGAAAATGATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTAAACTCTGGGAATT
TTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTTACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTACG
ATTATTCAAGATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTCATACCACATGACAAGGGGCCAGCAGCAATTG
AAGAATGCTGTAATTGGTTTCATAAAAGAATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAGTTAATTGCCTTTT
GGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGACCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCATTT
GAAGAGATAGACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCACACAATGGATGGGTAATGGGAGATGATCCTC
TTCGAAACTTTGCTGAACCGGGTTCAGAAGTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGAATAAACCAGAGGA
CTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCAACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTCAC
GTAGCTGAGTACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTCACAGGAAGTGAAGATCTGGACAATGTCTTTG
TTACTAGACTGGGCATTAGTTCCTTAATAAGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATGGAGGAGAACCTGT
TGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCACATGCCCTGTTTATGGATATTACGCATGATAATGAGTGTCCTATTGTGCAT
AGATCAGCGTATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACAAGAGGCTATGATGAATTAGTGCCTCATCAGA
TTTCAGTGGTTTCTGAAGAACGGTTTTACACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCGGCATTATTGCAGC
CAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTTATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAAGA
CACTCACCTAGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCATTTTACAGCAAGGAAGTGCCTCAAATGTGCA
TCCCTGGCAAAATTGAAGAAGTAGTTCTTGAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCAATGGAACACCAGA
TATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATTGTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAGAA
ATAGAATTTGAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAAGTCGCTGTTGGAATTCTTCGAAATCATCTGA
CACAATTCAGTCCTCACTTTAAATCTGGCAGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCTCCAGATTAACTTT
GGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAAGATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGCCCTTAAATATGCA
GGTCTTCAAGGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGTAATAATTTGAGATCTGGAGATTGGATGATTG
ACTATGTCAGTAACCGGCTTATTTCACGATCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGCAGATCCCACGTTA
CCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACTCTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTTCA
ACCTTTGTGAAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCAATTCTTTCACCTGCCCTAATGGATGTACCTT
ATAGGTTAAATGAGATCACAAAAGAAAAGGAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCCGCTGCTGGGGAAG
GGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTATGTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATGGT
CTCATTCCTAATCTACTGGGTGAAGGAATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGGCTGCAGTGTATCCAGGATTACTGTAAAATGG
TTCCAAATGGTCTAGACATTCTCAAGTGCCCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGGATCAGCCATTGTT
TGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTCCGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAGGT
TTTAATATAACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGCACATGGATGGATAAAATGGGAGAAAGTGACA
GAGCTAGAAACAGAGGAATCCCAGCCACACCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGTTGCTGGAATTATC
CAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGAAAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAAAATACAAGACAAC
TTTGAAAAGCTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCACAAACGTGGCATATACAAAGATAGTTATGGAG
CTTCAAGTCCTTGGTGTGACTATCAGCTCAGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAGCATGGAAAGCTTT
GGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTAGATCCAGATGATATGGTTTACTGTGGAATTTATGACAATGCATTAGACAAT
GACAACTACAATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTATTTTCTTCGTGCAAAATTATATTTTTCCAGAT
TGATGGGCCCGGAGACTACTGCAAAGACTATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTTGGAAAGGACTTCC
AGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACACAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTATGATTTATAGTTT
ATTACAGATATTAAGTATGCAATTACTTGTATTATAGGATGCAAGGTCATCATATGTAAATGCCTTATATGCACAGGCTCAAGTTGTTTTAAAAATCTCA
TTTATTATAATATTGATGCTCAATTAGGTAAGATTGTAAAAGCATTGATTTTTTTTAATGTACAGAGGTAGATTTCAATTTGAATCAGAAAGAAATATCA
TTACCAATGAAATGTGTTTGAGTTCAGTAAGAATTATTCAAATGCCTAGAAATCCATAGTTTGGAAAAGAAAAATCATGTCATCTTCTATTTGTACAGAA
ATGAAAATAAAATATGAAAATAATGAAAGAAATGAAAAGATAGCTTTTAATTGTGGTATATATAATCTTCAGTAACAATACATACTGAATACGCTGTGGT
TCATTAATATTAACACCACGTACTATAGTATTCTTAATACAGTGCTCACTGCATTTAATAAATATTTAATAAATGATGAATGATAGAAGTTTCCATCTAC
AATATATGTTCCTAAATGGAGCACAGATGTTCAAACTATGCTTTCATTTTTTCACTGATATATTAATTTTTGTGTAATGAATGCCAACAGTATATTTTAT
ATGATTTACTTATGTGAGGAAACATGCAAAGCATTAGGAAATTTATTTCCTAAAAACAGTTTTGTAAAATTAGTATTGAGTTCTATTGAGTATTATAAGA
TAGCTTACATTTTCAAAATGGAAATTGTCGGTCATATTTCTAGAACTTTAAAGAAAAAAGAATGTTATATTAGTTTTCTAAAACTCAACTATCTTTAGTC
ATGTTCAAAAATCTATTGCTAGATCATAGTAGATACTGGTTTTCTATTAACTCAAAACCTACATTGACAAGTTTAACATTGAGAAGAATCTTAACAAAAA
TATGGATATGAATTCAGTAGATATCTTAAATTCAATAAAATCACTGGAAGTTTTTCATGATAACTTATTTTAAGATGCCTTAAAAATCTTAAAGTCACAA
AAGGAAAAAGGTTTTTAACATTTACATGAGTTAACATTTTTTCATAGAACTTATTTCCTAGATAGAATTTTTTACTGTTTTTTACTGTTTTCTTAAGAAA
ACAGTTAAATCATTATGCATTCAGTTGGAAGAAAGTAGTGGCAAGAATTCTTTCATTGCTATATAATATTCAGTGGCTCATTTATACCTAATAAAATAAT
GGTATTTTAAAATAATGCTACTTTCAAAGTAGCATTTTTTTAGTTAGTTTACAGGTTACATACCCAAAACCTTAACTATGACTAAGAAATTAAAGAAGAA
AACCAGCAAACTAAAACTTCTGGGCAGCAAAAATATATAAATGCTTCAGATGTCAAATACCCATGCTTGAAAGCTCGTGTAATTTACTTTAAGATTATCT
GCCTGCTCTTCTTCAAAGCTGACCTTGCTTTAGAAATAGTTTTAACTAGCTTAGTTTTCTGGTTTCCAAAACTAAAATAGATTAAATCCTACAAATTTAA
GGACAGTTGTGACAGTAATCTGACCACTATCTATAAATACATTGGACATTGGTTTCCAAATCTCCCTTTCTTCTTCAGTTCCTTCCTTGTTCAATATATA
CCCTTCTCTAAACTGTGCGGGTAAAAGGAATGACTGTCCTTGAGAGAACCATTAGTTTATCAAAGGTTTATGTAGTTTTGTTGCTGTACCCTAACTTTGA
TATTCAGGGAGGTAGGAAAGGTAACAGAAAACCAGCATATTTAATCAAAGCAAGAAGTAATCGCTGACAGTTAAATGTGACCAAAAAAATTAAAAGTTCA
CAATTTTTTTAATGTAGCCATTTGGGGTTATCTCTAGTAAGGCAGATACCCACGTTGGTAAATTTTTAGGATATTGTGTTGCACTAGAAAACTAAGTGGT
TCATATTTCTAATGAGGAAGATTAATGAAAGAACATTGTTATATTCTGCGTGGTATATTTTAAAGTTTAAGAAGGCATGTTAAACATTATTTCCTCTATG
GTAGTTAAAATACAGAATTAGATTTTTAACAGGTGTCATTTGACTAAACGTTTCGGTAGAATGCTTCATACTTGAGTGATGCTGGATAAGGTATTGTATT
TCAACAATGGACTATGCCTTGGTTTTTCACTAATCAAAATCAAAATTACTCTTTAACATGATAAATGAATTTACCAGTTTAGTATGCTGTGGTATTTTAA
TAAGTTTTCAAAGATAATTGGGAAAACATGAGACTGGTCATATTGATGAATATTGTAACATGTGAATTGTGATCCATTTCTGATATGTCTTGAACTACTG
TGTCTAGTGGGCAAATGTCATTGTTACCTCTGTGTGTTAAGAAAATAAAAATATTTTCTAAAGGTC
- refseq_AGL.F1 (forward primer)
- refseq_AGL.R1 (reverse primer)
- Single exon skipping
Frame 0
LSTAAIPEATTASLCSHLPIGGWRPEFGNGEIAHLLSLSRLISWVTHSTVEFF*FL*KISNPLEAKM
GHSKQIRILLLNEMEKLEKTLFRLEQGYELQFR
LGPTLQGKAVTVYTNYPFPGETFNREKFRSLDW
ENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEK
SGGGYIVVDPILRVGADNHVLPLDCVTLQTFLA
KCLGPFDEWESRLRVAKESGYNMIHFTPLQTLG
LSRSCYSLANQLELNPDFSRPNRKYTWNDVGQLV
EKLKKEWNVICITDVVYNHTAANSKWIQEHPEC
AYNLVNSPHLKPAWVLDRALWRFSCDVAEGKYK
EKGIPALIENDHHMNSIRKIIWEDIFPKLKLWEF
FQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLT
IIQDPEYRRFGCTVDMNIALTTFIPHDKGPAAI
EECCNWFHKRMEELNSEKHRLINYHQEQAVNCLL
GNVFYERLAGHGPKLGPVTRKHPLVTRYFTFPF
EEIDFSMEESMIHLPNKACFLMAHNGWVMGDDP
LRNFAEPGSEVYLRRELICWGDSVKLRYGNKPED
CPYLWAHMKKYTEITATYFQGVRLDNCHSTPLH
VAEYMLDAARNLQPNLYVVAELFTGSEDLDNVF
VTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPV
GSFVQPCLRPLMPAIAHALFMDITHDNECPIVH
RSAYDALPSTTIVSMACCASGSTRGYDELVPHQ
ISVVSEERFYTKWNPEALPSNTGEVNFQSGIIAA
RCAISKLHQELGAKGFIQVYVDQVDEDIVAVTR
HSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMC
IPGKIEEVVLEARTIERNTKPYRKDENSINGTPD
ITVEIREHIQLNESKIVKQAGVATKGPNEYIQE
IEFENLSPGSVIIFRVSLDPHAQVAVGILRNHL
TQFSPHFKSGSLAVDNADPILKIPFASLASRLTL
AELNQILYRCESEEKEDGGGCYDIPNWSALKYA
GLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMI
DYVSNRLISRSGTIAEVGKWLQAMFFYLKQIPRY
LIPCYFDAILIGAYTTLLDTAWKQMSSFVQNGS
TFVKHLSLGSVQLCGVGKFPSLPILSPALMDVP
YRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWGR
DTFIALRGILLITGRYVEARNIILAFAGTLRHG
LIPNLLGEGIYARYNCRDAVWWWLQCIQDYCKM
VPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPLF
EVIQEAMQKHMQGIQFRERNAGPQIDRNMKDEG
FNITAGVDEETGFVYGGNRFNCGTWMDKMGESD
RARNRGIPATPRDGSAVEIVGLSKSAVRWLLELS
KKNIFPYHEVTVKRHGKAIKVSYDEWNRKIQDN
FEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYG
ASSPWCDYQLRPNFTIAMVVAPELFTTEKAWKAL
EIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDN
DNYNLAKGFNYHQGPEWLWPIGYFLRAKLYFSR
LMGPETTAKTIVLVKNVLSRHYVHLERSPWKGLP
ELTNENAQYCPFSCETQAWSIATILETLYDL*F
ITDIKYAITCIIGCKVIICKCLICTGSSCFKNL
IYYNIDAQLGKIVKALIFFNVQR*ISI*IRKKYH
YQ*NVFEFSKNYSNA*KSIVWKRKIMSSSICTE
MKIKYENNERNEKIAFNCGIYNLQ*QYILNTLW
FININTTYYSILNTVLTAFNKYLINDE**KFPST
IYVPKWSTDVQTMLSFFH*YINFCVMNANSIFY
MIYLCEETCKALGNLFPKNSFVKLVLSSIEYYK
IAYIFKMEIVGHISRTLKKKECYISFLKLNYL*S
CSKIYC*IIVDTGFLLTQNLH*QV*H*EES*QK
YGYEFSRYLKFNKITGSFS**LILRCLKNLKVT
KGKRFLTFT*VNIFS*NLFPR*NFLLFFTVFLRK
QLNHYAFSWKKVVARILSLLYNIQWLIYT**NN
GILK*CYFQSSIFLVSLQVTYPKP*L*LRN*RR
KPAN*NFWAAKIYKCFRCQIPMLESSCNLL*DYL
PALLQS*PCFRNSFN*LSFLVSKTKID*ILQI*
GQL*Q*SDHYL*IHWTLVSKSPFLLQFLPCSIY
TLL*TVRVKGMTVLERTISLSKVYVVLLLYPNFD
IQGGRKGNRKPAYLIKARSNR*QLNVTKKIKSS
QFF*CSHLGLSLVRQIPTLVNF*DIVLH*KTKW
FIFLMRKINERTLLYSAWYILKFKKAC*TLFPLW
*LKYRIRFLTGVI*LNVSVECFILE*CWIRYCI
STMDYALVFH*SKSKLLFNMINEFTSLVCCGIL
ISFQR*LGKHETGHIDEYCNM*IVIHF*YVLNYC
V*WANVIVTSVC*ENKNIF*R
Frame 1
CLRQLFQRQQLLPSVLISPLVAGDPNLGMGRLPTCYL*AD*SLG*LIRLWSSFNSYERFQIL*KPK
WDTVNRFEFYF*TKWRNWKRPSSDLNKGMSYSSD
*AQLYREKQLPCIQITHFLEKHLIEKNSVLWIG
KIQQKEKMILINTVNLICNNLVHFSIISFKEMR
KVVEVT*LWTPFYVLVLIIMCYPWTVLLFRHF*L
SVWDLLMNGKADLGLQKNQATT*FILPHCRLLD
YLGHATPLPIS*N*ILTFQDLIESIPGMMLDS*
WKN*KRNGMLFVLLMLSTIILLLIVNGSRNIQNV
PIIL*ILHT*NLPGS*TEHFGVSPVMLQKGNTK
KREYLL*LKMITI*IPSEK*FGRIFFQSLNSGN
FSK*MSTKRLSNLEDFLHKKIGE*PSLIQTNTLR
LFKILNTDGLAVL*I*TLH*RLSYHMTRGQQQL
KNAVIGFIKEWRN*IQRSIDSLTIIRNRQLIAF
WEMCFMNDWLAMVQN*DLSLESIL*LPGILLSHL
KR*TSPWKNL*FICQIKLVF*WHTMDG*WEMIL
FETLLNRVQKFT*GENLFAGETVLNYAMGINQR
TVLISGHT*KNTLK*LQLISREYVLITATQHLFT
*LSTCWMLLGICNPIYM**LNCSQEVKIWTMSL
LLDWALVP**ERQ*VHIIVMKRAD*FTDMEENL
LDPLFSPV*GL*CQLLHMPCLWILRMIMSVLLCI
DQRMMLFQVLQLFLWHVVLVEVQEAMMN*CLIR
FQWFLKNGFTLSGILKHCLQTQVKLISKAALLQ
PGVLSVNFIRSLEPRVLFRCMWIKLMKT*WQ*QD
THLASISLLWLYLELLSGIPRLHFTARKCLKCA
SLAKLKK*FLKLELLRETRNLIGRMRIQSMEHQ
ISQ*KLENIFSLMKVKLLNKLELPQKGPMNIFKK
*NLKTCLQEVLLYSELVLIHMHKSLLEFFEII*
HNSVLTLNLAA*LLTMQILY*KFLLLLLPPD*L
WLS*IRSFTDVNQKKRKMVEGAMTYQTGQPLNMQ
VFKV*CLYWQK*DQRMTWGILFVII*DLEIG*L
TMSVTGLFHDQELLLKLVNGCRLCSST*SRSHV
TLSHVTLMLY*LVHIPLFWIQHGSRCQALFRMVQ
PL*NTFHWVQFNCVE*ENSLPCQFFHLP*WMYL
IG*MRSQKKRSNVVFL*LQAYLIFLLVFSAAGE
GILLLHLEVYC*LLDAM*KPGILF*HLRVP*GMV
SFLIYWVKEFMPDTIVGMLCGGGCSVSRITVKW
FQMV*TFSSAQFPECILQMILLLCLLAHWISHC
LKSYRKQCKNTCRAYSSEKGMLVPR*IET*RTKV
LI*LQELMKKQDLFMEEIVSIVAHGWIKWEKVT
ELETEESQPHQEMGLLWKLWA*VNLLFAGCWNY
PKKIFSLIMKSQ*KDMERL*RSHMMSGTEKYKTT
LKSYFMFPKTLQI*MKSIQIWFTNVAYTKIVME
LQVLGVTISSGLILP*QWLWPLSSLLQKKHGKL
WRLQKKNCLVPLA*KL*IQMIWFTVEFMTMH*TM
TTTILLKVSIITKDLSGCGLLGIFFVQNYIFPD
*WARRLLQRL*FWLKMFFPDIMFILRDPLGKDF
QN*PMRMPSTVLSAVKHKPGQLLLFLRHFMIYSL
LQILSMQLLVL*DARSSYVNALYAQAQVVLKIS
FIIILMLN*VRL*KH*FFLMYRGRFQFESERNI
ITNEMCLSSVRIIQMPRNP*FGKEKSCHLLFVQK
*K*NMKIMKEMKR*LLIVVYIIFSNNTY*IRCG
SLILTPRTIVFLIQCSLHLINI**MMNDRSFHL
QYMFLNGAQMFKLCFHFFTDILIFV**MPTVYFI
*FTYVRKHAKH*EIYFLKTVL*N*Y*VLLSIIR
*LTFSKWKLSVIFLEL*RKKNVILVF*NSTIFS
HVQKSIARS**ILVFY*LKTYIDKFNIEKNLNKN
MDMNSVDILNSIKSLEVFHDNLF*DALKILKSQ
KEKGF*HLHELTFFHRTYFLDRIFYCFLLFS*E
NS*IIMHSVGRK*WQEFFHCYIIFSGSFIPNKIM
VF*NNATFKVAFF*LVYRLHTQNLNYD*EIKEE
NQQTKTSGQQKYINASDVKYPCLKARVIYFKII
CLLFFKADLALEIVLTSLVFWFPKLK*IKSYKFK
DSCDSNLTTIYKYIGHWFPNLPFFFSSFLVQYI
PFSKLCG*KE*LSLREPLVYQRFM*FCCCTLTL
IFREVGKVTENQHI*SKQEVIADS*M*PKKLKVH
NFFNVAIWGYL**GRYPRW*IFRILCCTRKLSG
SYF**GRLMKEHCYILRGIF*SLRRHVKHYFLY
GS*NTELDF*QVSFD*TFR*NASYLSDAG*GIVF
QQWTMPWFFTNQNQNYSLT**MNLPV*YAVVF*
*VFKDNWENMRLVILMNIVTCEL*SISDMS*TT
VSSGQMSLLPLCVKKIKIFSKG
Frame 2
VYGSYSRGNNCFPLFSSPHWWLATRIWEWGDCPPVIFEQTNLLGNSFDCGVLLILMKDFKSSRSQN
GTQ*TDSNFTSERNGETGKDPLQT*TRV*ATVP
IRPNFTGKSSYRVYKLPISWRNI**RKIPFSGLG
KSNRKRR*F**IL*T*SATIWFISVLFPSRK*E
KWWRLHSCGPHFTCWC**SCATLGLCYSSDIFS
*VFGTF**MGKQT*GCKRIRLQHDSFYPIADSWT
I*VMLLPCQSVRIKS*LFKT**KVYLE*CWTAS
GKIKKGMECYLYY*CCLQSYCC***MDPGTSRM
CL*SCEFSTLKTCLGLRQSTLAFLL*CCRREIQR
KGNTCFD*K*SPYEFHPKNNLGGYFSKA*TLGI
FPSRCQQSG*AI*KTSYTRK*ASNQV*SKPTPY
DYSRS*IQTVWLYCRYEHCTNDFHTT*QGASSN*
RML*LVS*KNGGIKFREASTH*LSSGTGS*LPF
GKCVL*TTGWPWSKTRTCH*KASFSYQVFYFPI
*RDRLLHGRIYDSSAK*SLFSDGTQWMGNGR*SS
SKLC*TGFRSLPKERTYLLGRQC*ITLWE*TRG
LSLSLGTHEKIH*NNCNLFPGSTS**LPLNTSS
RS*VHVGCC*EFATQFICSS*TVHRK*RSGQCLC
Y*TGH*FLNKRGNECI**S*RGQISLPIWRRTC
WILCSALFEAFNASYCTCPVYGYYA***VSYCA
*ISV*CSSKYYNCFYGMLC*WKYKRL**ISASSD
FSGF*RTVLH*VES*SIAFKHR*S*FPKRHYCS
QVCYQ*TSSGAWSQGFYSGVCGSS**RHSGSNK
TLT*HPSVCCGCI*NCFQESQDFILQQGSASNVH
PWQN*RSSS*S*NY*EKHETL*EG*EFNQWNTR
YHSRN*RTYSA**K*NC*TSWSCHKRAQ*IYSR
NRI*KLVSRKCYYIQS*S*STCTSRCWNSSKSSD
TIQSSL*IWQPSC*QCRSYIKNSFCFSCLQINF
G*AKSDPLPM*IRRKGRWWRVL*HTKLVSP*IC
RSSRFNVCIGRNKTKE*LGASFL**FEIWRLDD*
LCQ*PAYFTIRNYC*SW*MVAGYVLLPEADPTL
PYPMLL*CYINWCIYHSSGYSMEADVKLCSEWF
NLCETPFIGFSSTVWSRKIPFPANSFTCPNGCTL
*VK*DHKRKGAMLCFSSCRLTSFFFWYFPLLGK
GYFYCT*RYTADYWTLCRSQEYYFSICGYPEAW
SHS*STG*RNLCQIQLSGCCVVVAAVYPGLL*NG
SKWSRHSQVPSFQNVSYR*FCSFACWHTGSAIV
*SHTGSNAKTHAGHTVPRKECWSPDRSKHEGRR
F*YNCRS**RNRICLWRKSFQLWHMDG*NGRK*Q
S*KQRNPSHTKRWVCCGNCGPE*ICCSLVAGII
QKKYFPLS*SHSKKTWKGYKGLI**VEQKNTRQ
L*KAISCFRRPFRFK*KASKSGSQTWHIQR*LWS
FKSLV*LSAQA*FYHSNGCGP*ALYYRKSMESF
GDCRKKIAWSPWHENFRSR*YGLLWNL*QCIRQ
*QLQSC*RFQLSPRT*VAVAYWVFSSCKIIFFQI
DGPGDYCKDYSFG*KCSFPTLCSS*EIPLERTS
RTDQ*ECPVLSFQL*NTSLVNCYYS*DTL*FIV
YYRY*VCNYLYYRMQGHHM*MPYMHRLKLF*KSH
LL*Y*CSIR*DCKSIDFF*CTEVDFNLNQKEIS
LPMKCV*VQ*ELFKCLEIHSLEKKNHVIFYLYR
NENKI*K**KK*KDSF*LWYI*SSVTIHTEYAVV
H*Y*HHVL*YS*YSAHCI**IFNK**MIEVSIY
NICS*MEHRCSNYAFIFSLIY*FLCNECQQYIL
YDLLM*GNMQSIRKFIS*KQFCKISIEFY*VL*D
SLHFQNGNCRSYF*NFKEKRMLY*FSKTQLSLV
MFKNLLLDHSRYWFSINSKPTLTSLTLRRILTK
IWI*IQ*IS*IQ*NHWKFFMITYFKMP*KS*SHK
RKKVFNIYMS*HFFIELIS*IEFFTVFYCFLKK
TVKSLCIQLEESSGKNSFIAI*YSVAHLYLIK*
WYFKIMLLSK*HFFS*FTGYIPKTLTMTKKLKKK
TSKLKLLGSKNI*MLQMSNTHA*KLV*FTLRLS
ACSSSKLTLL*K*F*LA*FSGFQN*NRLNPTNL
RTVVTVI*PLSINTLDIGFQISLSSSVPSLFNIY
PSLNCAGKRNDCP*ENH*FIKGLCSFVAVP*L*
YSGR*ER*QKTSIFNQSKK*SLTVKCDQKN*KF
TIFLM*PFGVISSKADTHVGKFLGYCVALEN*VV
HISNEED**KNIVIFCVVYFKV*EGMLNIISSM
VVKIQN*IFNRCHLTKRFGRMLHT*VMLDKVLY
FNNGLCLGFSLIKIKITL*HDK*IYQFSMLWYFN
KFSKIIGKT*DWSY**IL*HVNCDPFLICLELL
CLVGKCHCYLCVLRK*KYFLKV
Sequence NM_000028
CTGTCTACGGCAGCTATTCCAGAGGCAACAACTGCTTCCCTCTGTTCTCATCTCCCCATTGGTGGCTGGCGACCCGAATTTGGGAATGGGGAGATTGCCCACCTGTTATCTTTGAGCAGACTAATCTCTTGTAAGCAGAAGTGCCATTCGGAGTCTCCAGAGCCCTGTGGCTTGGGGCTGGGAATGTCCCCCTGACTTCA
GGCTTTCCTAAGTGTATTGCTTTTCTCTGAGAATGGTCTAGGTTTTTAATTTTTTAATTGTAAGAATCTGTAATACAGCATTTTTATTTCGGTCTTATTC
GTTGTGCTCAAAGGCAGGAAACAACTATTAATTTGCCTTCTCGAATCTTAATAGTTATAAGATTCATTCTCTTTCATTGCTCTGCTAGGCATAAAACACA
CTTCGAACATGGGTAACTCATTCGACTGTGGAGTTCTTTTAATTCTTATGAAAGATTTCAAATCCTCTAGAAGCCAAAATGGGACACAGTAAACAGATTC
GAATTTTACTTCTGAACGAAATGGAGAAACTGGAAAAGACCCTCTTCAGACTTGAACAAGGGTATGAGCTACAGTTCCGATTAGGCCCAACTTTACAGGG
AAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTTAATAGAGAAAAATTCCGTTCTCTGGATTGGGAAAATCCAACAGAAAGAGAA
GATGATTCTGATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTCAAGGAAATGAGAAAAGTGGTGGAGGTTACATAG
TTGTGGACCCCATTTTACGTGTTGGTGCTGATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAGCTAAGTGTTTGGGACCTTTTGA
TGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATGATTCATTTTACCCCATTGCAGACTCTTGGACTATCTAGGTCATGCTACTCC
CTTGCCAATCAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATGTTGGACAGCTAGTGGAAAAATTAAAAAAGGAAT
GGAATGTTATTTGTATTACTGATGTTGTCTACAATCATACTGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAATGTGCCTATAATCTTGTGAATTC
TCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTCTCCTGTGATGTTGCAGAAGGGAAATACAAAGAAAAGGGAATACCTGCTTTG
ATTGAAAATGATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTAAACTCTGGGAATTTTTCCAAGTAGATGTCAACA
AAGCGGTTGAGCAATTTAGAAGACTTCTTACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTACGATTATTCAAGATCCTGAATA
CAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTCATACCACATGACAAGGGGCCAGCAGCAATTGAAGAATGCTGTAATTGGTTT
CATAAAAGAATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAGTTAATTGCCTTTTGGGAAATGTGTTTTATGAAC
GACTGGCTGGCCATGGTCCAAAACTAGGACCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCATTTGAAGAGATAGACTTCTCCAT
GGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCACACAATGGATGGGTAATGGGAGATGATCCTCTTCGAAACTTTGCTGAACCG
GGTTCAGAAGTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGAATAAACCAGAGGACTGTCCTTATCTCTGGGCAC
ACATGAAAAAATACACTGAAATAACTGCAACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTCACGTAGCTGAGTACATGTTGGA
TGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTCACAGGAAGTGAAGATCTGGACAATGTCTTTGTTACTAGACTGGGCATTAGT
TCCTTAATAAGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATGGAGGAGAACCTGTTGGATCCTTTGTTCAGCCCT
GTTTGAGGCCTTTAATGCCAGCTATTGCACATGCCCTGTTTATGGATATTACGCATGATAATGAGTGTCCTATTGTGCATAGATCAGCGTATGATGCTCT
TCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACAAGAGGCTATGATGAATTAGTGCCTCATCAGATTTCAGTGGTTTCTGAAGAA
CGGTTTTACACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCGGCATTATTGCAGCCAGGTGTGCTATCAGTAAAC
TTCATCAGGAGCTTGGAGCCAAGGGTTTTATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAAGACACTCACCTAGCATCCATCA
GTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCATTTTACAGCAAGGAAGTGCCTCAAATGTGCATCCCTGGCAAAATTGAAGAA
GTAGTTCTTGAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCAATGGAACACCAGATATCACAGTAGAAATTAGAG
AACATATTCAGCTTAATGAAAGTAAAATTGTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAGAAATAGAATTTGAAAACTTGTC
TCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAAGTCGCTGTTGGAATTCTTCGAAATCATCTGACACAATTCAGTCCTCACTTT
AAATCTGGCAGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCTCCAGATTAACTTTGGCTGAGCTAAATCAGATCC
TTTACCGATGTGAATCAGAAGAAAAGGAAGATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGCCCTTAAATATGCAGGTCTTCAAGGTTTAATGTC
TGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGTAATAATTTGAGATCTGGAGATTGGATGATTGACTATGTCAGTAACCGGCTT
ATTTCACGATCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGCAGATCCCACGTTACCTTATCCCATGTTACTTTG
ATGCTATATTAATTGGTGCATATACCACTCTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTTCAACCTTTGTGAAACACCTTTC
ATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCAATTCTTTCACCTGCCCTAATGGATGTACCTTATAGGTTAAATGAGATCACA
AAAGAAAAGGAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCCGCTGCTGGGGAAGGGATACTTTTATTGCACTTA
GAGGTATACTGCTGATTACTGGACGCTATGTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATGGTCTCATTCCTAATCTACTGGG
TGAAGGAATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGGCTGCAGTGTATCCAGGATTACTGTAAAATGGTTCCAAATGGTCTAGACATT
CTCAAGTGCCCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGGATCAGCCATTGTTTGAAGTCATACAGGAAGCAA
TGCAAAAACACATGCAGGGCATACAGTTCCGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAGGTTTTAATATAACTGCAGGAGT
TGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGCACATGGATGGATAAAATGGGAGAAAGTGACAGAGCTAGAAACAGAGGAATC
CCAGCCACACCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGTTGCTGGAATTATCCAAAAAAAATATTTTCCCTT
ATCATGAAGTCACAGTAAAAAGACATGGAAAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAAAATACAAGACAACTTTGAAAAGCTATTTCATGT
TTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCACAAACGTGGCATATACAAAGATAGTTATGGAGCTTCAAGTCCTTGGTGTGAC
TATCAGCTCAGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAGCATGGAAAGCTTTGGAGATTGCAGAAAAAAAAT
TGCTTGGTCCCCTTGGCATGAAAACTTTAGATCCAGATGATATGGTTTACTGTGGAATTTATGACAATGCATTAGACAATGACAACTACAATCTTGCTAA
AGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTATTTTCTTCGTGCAAAATTATATTTTTCCAGATTGATGGGCCCGGAGACTACT
GCAAAGACTATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTTGGAAAGGACTTCCAGAACTGACCAATGAGAATG
CCCAGTACTGTCCTTTCAGCTGTGAAACACAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTATGATTTATAGTTTATTACAGATATTAAGTATGC
AATTACTTGTATTATAGGATGCAAGGTCATCATATGTAAATGCCTTATATGCACAGGCTCAAGTTGTTTTAAAAATCTCATTTATTATAATATTGATGCT
CAATTAGGTAAGATTGTAAAAGCATTGATTTTTTTTAATGTACAGAGGTAGATTTCAATTTGAATCAGAAAGAAATATCATTACCAATGAAATGTGTTTG
AGTTCAGTAAGAATTATTCAAATGCCTAGAAATCCATAGTTTGGAAAAGAAAAATCATGTCATCTTCTATTTGTACAGAAATGAAAATAAAATATGAAAA
TAATGAAAGAAATGAAAAGATAGCTTTTAATTGTGGTATATATAATCTTCAGTAACAATACATACTGAATACGCTGTGGTTCATTAATATTAACACCACG
TACTATAGTATTCTTAATACAGTGCTCACTGCATTTAATAAATATTTAATAAATGATGAATGATAGAAGTTTCCATCTACAATATATGTTCCTAAATGGA
GCACAGATGTTCAAACTATGCTTTCATTTTTTCACTGATATATTAATTTTTGTGTAATGAATGCCAACAGTATATTTTATATGATTTACTTATGTGAGGA
AACATGCAAAGCATTAGGAAATTTATTTCCTAAAAACAGTTTTGTAAAATTAGTATTGAGTTCTATTGAGTATTATAAGATAGCTTACATTTTCAAAATG
GAAATTGTCGGTCATATTTCTAGAACTTTAAAGAAAAAAGAATGTTATATTAGTTTTCTAAAACTCAACTATCTTTAGTCATGTTCAAAAATCTATTGCT
AGATCATAGTAGATACTGGTTTTCTATTAACTCAAAACCTACATTGACAAGTTTAACATTGAGAAGAATCTTAACAAAAATATGGATATGAATTCAGTAG
ATATCTTAAATTCAATAAAATCACTGGAAGTTTTTCATGATAACTTATTTTAAGATGCCTTAAAAATCTTAAAGTCACAAAAGGAAAAAGGTTTTTAACA
TTTACATGAGTTAACATTTTTTCATAGAACTTATTTCCTAGATAGAATTTTTTACTGTTTTTTACTGTTTTCTTAAGAAAACAGTTAAATCATTATGCAT
TCAGTTGGAAGAAAGTAGTGGCAAGAATTCTTTCATTGCTATATAATATTCAGTGGCTCATTTATACCTAATAAAATAATGGTATTTTAAAATAATGCTA
CTTTCAAAGTAGCATTTTTTTAGTTAGTTTACAGGTTACATACCCAAAACCTTAACTATGACTAAGAAATTAAAGAAGAAAACCAGCAAACTAAAACTTC
TGGGCAGCAAAAATATATAAATGCTTCAGATGTCAAATACCCATGCTTGAAAGCTCGTGTAATTTACTTTAAGATTATCTGCCTGCTCTTCTTCAAAGCT
GACCTTGCTTTAGAAATAGTTTTAACTAGCTTAGTTTTCTGGTTTCCAAAACTAAAATAGATTAAATCCTACAAATTTAAGGACAGTTGTGACAGTAATC
TGACCACTATCTATAAATACATTGGACATTGGTTTCCAAATCTCCCTTTCTTCTTCAGTTCCTTCCTTGTTCAATATATACCCTTCTCTAAACTGTGCGG
GTAAAAGGAATGACTGTCCTTGAGAGAACCATTAGTTTATCAAAGGTTTATGTAGTTTTGTTGCTGTACCCTAACTTTGATATTCAGGGAGGTAGGAAAG
GTAACAGAAAACCAGCATATTTAATCAAAGCAAGAAGTAATCGCTGACAGTTAAATGTGACCAAAAAAATTAAAAGTTCACAATTTTTTTAATGTAGCCA
TTTGGGGTTATCTCTAGTAAGGCAGATACCCACGTTGGTAAATTTTTAGGATATTGTGTTGCACTAGAAAACTAAGTGGTTCATATTTCTAATGAGGAAG
ATTAATGAAAGAACATTGTTATATTCTGCGTGGTATATTTTAAAGTTTAAGAAGGCATGTTAAACATTATTTCCTCTATGGTAGTTAAAATACAGAATTA
GATTTTTAACAGGTGTCATTTGACTAAACGTTTCGGTAGAATGCTTCATACTTGAGTGATGCTGGATAAGGTATTGTATTTCAACAATGGACTATGCCTT
GGTTTTTCACTAATCAAAATCAAAATTACTCTTTAACATGATAAATGAATTTACCAGTTTAGTATGCTGTGGTATTTTAATAAGTTTTCAAAGATAATTG
GGAAAACATGAGACTGGTCATATTGATGAATATTGTAACATGTGAATTGTGATCCATTTCTGATATGTCTTGAACTACTGTGTCTAGTGGGCAAATGTCA
TTGTTACCTCTGTGTGTTAAGAAAATAAAAATATTTTCTAAAGGTC
- refseq_AGL.F1 (forward primer)
- refseq_AGL.R1 (reverse primer)
- Single exon skipping
Frame 0
LSTAAIPEATTASLCSHLPIGGWRPEFGNGEIAHLLSLSRLISCKQKCHSESPEPCGLGLGMSP*LQ
AFLSVLLFSENGLGF*FFNCKNL*YSIFISVLF
VVLKGRKQLLICLLES**L*DSFSFIALLGIKH
TSNMGNSFDCGVLLILMKDFKSSRSQNGTQ*TDS
NFTSERNGETGKDPLQT*TRV*ATVPIRPNFTG
KSSYRVYKLPISWRNI**RKIPFSGLGKSNRKR
R*F**IL*T*SATIWFISVLFPSRK*EKWWRLHS
CGPHFTCWC**SCATLGLCYSSDIFS*VFGTF*
*MGKQT*GCKRIRLQHDSFYPIADSWTI*VMLL
PCQSVRIKS*LFKT**KVYLE*CWTASGKIKKGM
ECYLYY*CCLQSYCC***MDPGTSRMCL*SCEF
STLKTCLGLRQSTLAFLL*CCRREIQRKGNTCF
D*K*SPYEFHPKNNLGGYFSKA*TLGIFPSRCQQ
SG*AI*KTSYTRK*ASNQV*SKPTPYDYSRS*I
QTVWLYCRYEHCTNDFHTT*QGASSN*RML*LV
S*KNGGIKFREASTH*LSSGTGS*LPFGKCVL*T
TGWPWSKTRTCH*KASFSYQVFYFPI*RDRLLH
GRIYDSSAK*SLFSDGTQWMGNGR*SSSKLC*T
GFRSLPKERTYLLGRQC*ITLWE*TRGLSLSLGT
HEKIH*NNCNLFPGSTS**LPLNTSSRS*VHVG
CC*EFATQFICSS*TVHRK*RSGQCLCY*TGH*
FLNKRGNECI**S*RGQISLPIWRRTCWILCSAL
FEAFNASYCTCPVYGYYA***VSYCA*ISV*CS
SKYYNCFYGMLC*WKYKRL**ISASSDFSGF*R
TVLH*VES*SIAFKHR*S*FPKRHYCSQVCYQ*T
SSGAWSQGFYSGVCGSS**RHSGSNKTLT*HPS
VCCGCI*NCFQESQDFILQQGSASNVHPWQN*R
SSS*S*NY*EKHETL*EG*EFNQWNTRYHSRN*R
TYSA**K*NC*TSWSCHKRAQ*IYSRNRI*KLV
SRKCYYIQS*S*STCTSRCWNSSKSSDTIQSSL
*IWQPSC*QCRSYIKNSFCFSCLQINFG*AKSDP
LPM*IRRKGRWWRVL*HTKLVSP*ICRSSRFNV
CIGRNKTKE*LGASFL**FEIWRLDD*LCQ*PA
YFTIRNYC*SW*MVAGYVLLPEADPTLPYPMLL*
CYINWCIYHSSGYSMEADVKLCSEWFNLCETPF
IGFSSTVWSRKIPFPANSFTCPNGCTL*VK*DH
KRKGAMLCFSSCRLTSFFFWYFPLLGKGYFYCT*
RYTADYWTLCRSQEYYFSICGYPEAWSHS*STG
*RNLCQIQLSGCCVVVAAVYPGLL*NGSKWSRH
SQVPSFQNVSYR*FCSFACWHTGSAIV*SHTGSN
AKTHAGHTVPRKECWSPDRSKHEGRRF*YNCRS
**RNRICLWRKSFQLWHMDG*NGRK*QS*KQRN
PSHTKRWVCCGNCGPE*ICCSLVAGIIQKKYFPL
S*SHSKKTWKGYKGLI**VEQKNTRQL*KAISC
FRRPFRFK*KASKSGSQTWHIQR*LWSFKSLV*
LSAQA*FYHSNGCGP*ALYYRKSMESFGDCRKKI
AWSPWHENFRSR*YGLLWNL*QCIRQ*QLQSC*
RFQLSPRT*VAVAYWVFSSCKIIFFQIDGPGDY
CKDYSFG*KCSFPTLCSS*EIPLERTSRTDQ*EC
PVLSFQL*NTSLVNCYYS*DTL*FIVYYRY*VC
NYLYYRMQGHHM*MPYMHRLKLF*KSHLL*Y*C
SIR*DCKSIDFF*CTEVDFNLNQKEISLPMKCV*
VQ*ELFKCLEIHSLEKKNHVIFYLYRNENKI*K
**KK*KDSF*LWYI*SSVTIHTEYAVVH*Y*HH
VL*YS*YSAHCI**IFNK**MIEVSIYNICS*ME
HRCSNYAFIFSLIY*FLCNECQQYILYDLLM*G
NMQSIRKFIS*KQFCKISIEFY*VL*DSLHFQN
GNCRSYF*NFKEKRMLY*FSKTQLSLVMFKNLLL
DHSRYWFSINSKPTLTSLTLRRILTKIWI*IQ*
IS*IQ*NHWKFFMITYFKMP*KS*SHKRKKVFN
IYMS*HFFIELIS*IEFFTVFYCFLKKTVKSLCI
QLEESSGKNSFIAI*YSVAHLYLIK*WYFKIML
LSK*HFFS*FTGYIPKTLTMTKKLKKKTSKLKL
LGSKNI*MLQMSNTHA*KLV*FTLRLSACSSSKL
TLL*K*F*LA*FSGFQN*NRLNPTNLRTVVTVI
*PLSINTLDIGFQISLSSSVPSLFNIYPSLNCA
GKRNDCP*ENH*FIKGLCSFVAVP*L*YSGR*ER
*QKTSIFNQSKK*SLTVKCDQKN*KFTIFLM*P
FGVISSKADTHVGKFLGYCVALEN*VVHISNEE
D**KNIVIFCVVYFKV*EGMLNIISSMVVKIQN*
IFNRCHLTKRFGRMLHT*VMLDKVLYFNNGLCL
GFSLIKIKITL*HDK*IYQFSMLWYFNKFSKII
GKT*DWSY**IL*HVNCDPFLICLELLCLVGKCH
CYLCVLRK*KYFLKV
Frame 1
CLRQLFQRQQLLPSVLISPLVAGDPNLGMGRLPTCYL*AD*SLVSRSAIRSLQSPVAWGWECPPDF
RLS*VYCFSLRMV*VFNFLIVRICNTAFLFRSYS
LCSKAGNNY*FAFSNLNSYKIHSLSLLC*A*NT
LRTWVTHSTVEFF*FL*KISNPLEAKMGHSKQI
RILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQG
KAVTVYTNYPFPGETFNREKFRSLDWENPTERE
DDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYI
VVDPILRVGADNHVLPLDCVTLQTFLAKCLGPFD
EWESRLRVAKESGYNMIHFTPLQTLGLSRSCYS
LANQLELNPDFSRPNRKYTWNDVGQLVEKLKKE
WNVICITDVVYNHTAANSKWIQEHPECAYNLVNS
PHLKPAWVLDRALWRFSCDVAEGKYKEKGIPAL
IENDHHMNSIRKIIWEDIFPKLKLWEFFQVDVN
KAVEQFRRLLTQENRRVTKSDPNQHLTIIQDPEY
RRFGCTVDMNIALTTFIPHDKGPAAIEECCNWF
HKRMEELNSEKHRLINYHQEQAVNCLLGNVFYE
RLAGHGPKLGPVTRKHPLVTRYFTFPFEEIDFSM
EESMIHLPNKACFLMAHNGWVMGDDPLRNFAEP
GSEVYLRRELICWGDSVKLRYGNKPEDCPYLWA
HMKKYTEITATYFQGVRLDNCHSTPLHVAEYMLD
AARNLQPNLYVVAELFTGSEDLDNVFVTRLGIS
SLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQP
CLRPLMPAIAHALFMDITHDNECPIVHRSAYDAL
PSTTIVSMACCASGSTRGYDELVPHQISVVSEE
RFYTKWNPEALPSNTGEVNFQSGIIAARCAISK
LHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQ
SVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEE
VVLEARTIERNTKPYRKDENSINGTPDITVEIR
EHIQLNESKIVKQAGVATKGPNEYIQEIEFENLS
PGSVIIFRVSLDPHAQVAVGILRNHLTQFSPHF
KSGSLAVDNADPILKIPFASLASRLTLAELNQI
LYRCESEEKEDGGGCYDIPNWSALKYAGLQGLMS
VLAEIRPKNDLGHPFCNNLRSGDWMIDYVSNRL
ISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYF
DAILIGAYTTLLDTAWKQMSSFVQNGSTFVKHLS
LGSVQLCGVGKFPSLPILSPALMDVPYRLNEIT
KEKEQCCVSLAAGLPHFSSGIFRCWGRDTFIAL
RGILLITGRYVEARNIILAFAGTLRHGLIPNLLG
EGIYARYNCRDAVWWWLQCIQDYCKMVPNGLDI
LKCPVSRMYPTDDSAPLPAGTLDQPLFEVIQEA
MQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGV
DEETGFVYGGNRFNCGTWMDKMGESDRARNRGI
PATPRDGSAVEIVGLSKSAVRWLLELSKKNIFP
YHEVTVKRHGKAIKVSYDEWNRKIQDNFEKLFHV
SEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCD
YQLRPNFTIAMVVAPELFTTEKAWKALEIAEKK
LLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLAK
GFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETT
AKTIVLVKNVLSRHYVHLERSPWKGLPELTNEN
AQYCPFSCETQAWSIATILETLYDL*FITDIKYA
ITCIIGCKVIICKCLICTGSSCFKNLIYYNIDA
QLGKIVKALIFFNVQR*ISI*IRKKYHYQ*NVF
EFSKNYSNA*KSIVWKRKIMSSSICTEMKIKYEN
NERNEKIAFNCGIYNLQ*QYILNTLWFININTT
YYSILNTVLTAFNKYLINDE**KFPSTIYVPKW
STDVQTMLSFFH*YINFCVMNANSIFYMIYLCEE
TCKALGNLFPKNSFVKLVLSSIEYYKIAYIFKM
EIVGHISRTLKKKECYISFLKLNYL*SCSKIYC
*IIVDTGFLLTQNLH*QV*H*EES*QKYGYEFSR
YLKFNKITGSFS**LILRCLKNLKVTKGKRFLT
FT*VNIFS*NLFPR*NFLLFFTVFLRKQLNHYA
FSWKKVVARILSLLYNIQWLIYT**NNGILK*CY
FQSSIFLVSLQVTYPKP*L*LRN*RRKPAN*NF
WAAKIYKCFRCQIPMLESSCNLL*DYLPALLQS
*PCFRNSFN*LSFLVSKTKID*ILQI*GQL*Q*S
DHYL*IHWTLVSKSPFLLQFLPCSIYTLL*TVR
VKGMTVLERTISLSKVYVVLLLYPNFDIQGGRK
GNRKPAYLIKARSNR*QLNVTKKIKSSQFF*CSH
LGLSLVRQIPTLVNF*DIVLH*KTKWFIFLMRK
INERTLLYSAWYILKFKKAC*TLFPLW*LKYRI
RFLTGVI*LNVSVECFILE*CWIRYCISTMDYAL
VFH*SKSKLLFNMINEFTSLVCCGILISFQR*L
GKHETGHIDEYCNM*IVIHF*YVLNYCV*WANV
IVTSVC*ENKNIF*R
Frame 2
VYGSYSRGNNCFPLFSSPHWWLATRIWEWGDCPPVIFEQTNLL*AEVPFGVSRALWLGAGNVPLTS
GFPKCIAFL*EWSRFLIF*L*ESVIQHFYFGLI
RCAQRQETTINLPSRILIVIRFILFHCSARHKTH
FEHG*LIRLWSSFNSYERFQIL*KPKWDTVNRF
EFYF*TKWRNWKRPSSDLNKGMSYSSD*AQLYR
EKQLPCIQITHFLEKHLIEKNSVLWIGKIQQKEK
MILINTVNLICNNLVHFSIISFKEMRKVVEVT*
LWTPFYVLVLIIMCYPWTVLLFRHF*LSVWDLL
MNGKADLGLQKNQATT*FILPHCRLLDYLGHATP
LPIS*N*ILTFQDLIESIPGMMLDS*WKN*KRN
GMLFVLLMLSTIILLLIVNGSRNIQNVPIIL*I
LHT*NLPGS*TEHFGVSPVMLQKGNTKKREYLL*
LKMITI*IPSEK*FGRIFFQSLNSGNFSK*MST
KRLSNLEDFLHKKIGE*PSLIQTNTLRLFKILN
TDGLAVL*I*TLH*RLSYHMTRGQQQLKNAVIGF
IKEWRN*IQRSIDSLTIIRNRQLIAFWEMCFMN
DWLAMVQN*DLSLESIL*LPGILLSHLKR*TSP
WKNL*FICQIKLVF*WHTMDG*WEMILFETLLNR
VQKFT*GENLFAGETVLNYAMGINQRTVLISGH
T*KNTLK*LQLISREYVLITATQHLFT*LSTCW
MLLGICNPIYM**LNCSQEVKIWTMSLLLDWALV
P**ERQ*VHIIVMKRAD*FTDMEENLLDPLFSP
V*GL*CQLLHMPCLWILRMIMSVLLCIDQRMML
FQVLQLFLWHVVLVEVQEAMMN*CLIRFQWFLKN
GFTLSGILKHCLQTQVKLISKAALLQPGVLSVN
FIRSLEPRVLFRCMWIKLMKT*WQ*QDTHLASI
SLLWLYLELLSGIPRLHFTARKCLKCASLAKLKK
*FLKLELLRETRNLIGRMRIQSMEHQISQ*KLE
NIFSLMKVKLLNKLELPQKGPMNIFKK*NLKTC
LQEVLLYSELVLIHMHKSLLEFFEII*HNSVLTL
NLAA*LLTMQILY*KFLLLLLPPD*LWLS*IRS
FTDVNQKKRKMVEGAMTYQTGQPLNMQVFKV*C
LYWQK*DQRMTWGILFVII*DLEIG*LTMSVTGL
FHDQELLLKLVNGCRLCSST*SRSHVTLSHVTL
MLY*LVHIPLFWIQHGSRCQALFRMVQPL*NTF
HWVQFNCVE*ENSLPCQFFHLP*WMYLIG*MRSQ
KKRSNVVFL*LQAYLIFLLVFSAAGEGILLLHL
EVYC*LLDAM*KPGILF*HLRVP*GMVSFLIYW
VKEFMPDTIVGMLCGGGCSVSRITVKWFQMV*TF
SSAQFPECILQMILLLCLLAHWISHCLKSYRKQ
CKNTCRAYSSEKGMLVPR*IET*RTKVLI*LQE
LMKKQDLFMEEIVSIVAHGWIKWEKVTELETEES
QPHQEMGLLWKLWA*VNLLFAGCWNYPKKIFSL
IMKSQ*KDMERL*RSHMMSGTEKYKTTLKSYFM
FPKTLQI*MKSIQIWFTNVAYTKIVMELQVLGVT
ISSGLILP*QWLWPLSSLLQKKHGKLWRLQKKN
CLVPLA*KL*IQMIWFTVEFMTMH*TMTTTILL
KVSIITKDLSGCGLLGIFFVQNYIFPD*WARRLL
QRL*FWLKMFFPDIMFILRDPLGKDFQN*PMRM
PSTVLSAVKHKPGQLLLFLRHFMIYSLLQILSM
QLLVL*DARSSYVNALYAQAQVVLKISFIIILML
N*VRL*KH*FFLMYRGRFQFESERNIITNEMCL
SSVRIIQMPRNP*FGKEKSCHLLFVQK*K*NMK
IMKEMKR*LLIVVYIIFSNNTY*IRCGSLILTPR
TIVFLIQCSLHLINI**MMNDRSFHLQYMFLNG
AQMFKLCFHFFTDILIFV**MPTVYFI*FTYVR
KHAKH*EIYFLKTVL*N*Y*VLLSIIR*LTFSKW
KLSVIFLEL*RKKNVILVF*NSTIFSHVQKSIA
RS**ILVFY*LKTYIDKFNIEKNLNKNMDMNSV
DILNSIKSLEVFHDNLF*DALKILKSQKEKGF*H
LHELTFFHRTYFLDRIFYCFLLFS*ENS*IIMH
SVGRK*WQEFFHCYIIFSGSFIPNKIMVF*NNA
TFKVAFF*LVYRLHTQNLNYD*EIKEENQQTKTS
GQQKYINASDVKYPCLKARVIYFKIICLLFFKA
DLALEIVLTSLVFWFPKLK*IKSYKFKDSCDSN
LTTIYKYIGHWFPNLPFFFSSFLVQYIPFSKLCG
*KE*LSLREPLVYQRFM*FCCCTLTLIFREVGK
VTENQHI*SKQEVIADS*M*PKKLKVHNFFNVA
IWGYL**GRYPRW*IFRILCCTRKLSGSYF**GR
LMKEHCYILRGIF*SLRRHVKHYFLYGS*NTEL
DF*QVSFD*TFR*NASYLSDAG*GIVFQQWTMP
WFFTNQNQNYSLT**MNLPV*YAVVF**VFKDNW
ENMRLVILMNIVTCEL*SISDMS*TTVSSGQMS
LLPLCVKKIKIFSKG
Sequence NM_000644
CTGTCTACGGCAGCTATTCCAGAGGCAACAACTGCTTCCCTCTGTTCTCATCTCCCCATTGGTGGCTGGCGACCCGAATTTGGGAATGGGGAGATTGCCCACCTGTTATCTTTGAGCAGACTAATCTCTTAAGCCAAAATGGGACACAGTAAACAGATTCGAATTTTACTTCTGAACGAAATGGAGAAACTGGAAAAGAC
CCTCTTCAGACTTGAACAAGGGTATGAGCTACAGTTCCGATTAGGCCCAACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGA
GAAACATTTAATAGAGAAAAATTCCGTTCTCTGGATTGGGAAAATCCAACAGAAAGAGAAGATGATTCTGATAAATACTGTAAACTTAATCTGCAACAAT
CTGGTTCATTTCAGTATTATTTCCTTCAAGGAAATGAGAAAAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCTGATAATCATGT
GCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAGCTAAGTGTTTGGGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGC
TACAACATGATTCATTTTACCCCATTGCAGACTCTTGGACTATCTAGGTCATGCTACTCCCTTGCCAATCAGTTAGAATTAAATCCTGACTTTTCAAGAC
CTAATAGAAAGTATACCTGGAATGATGTTGGACAGCTAGTGGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTCTACAATCATAC
TGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAATGTGCCTATAATCTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTT
TGGCGTTTCTCCTGTGATGTTGCAGAAGGGAAATACAAAGAAAAGGGAATACCTGCTTTGATTGAAAATGATCACCATATGAATTCCATCCGAAAAATAA
TTTGGGAGGATATTTTTCCAAAGCTTAAACTCTGGGAATTTTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTTACACAAGAAAA
TAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTACGATTATTCAAGATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTA
ACGACTTTCATACCACATGACAAGGGGCCAGCAGCAATTGAAGAATGCTGTAATTGGTTTCATAAAAGAATGGAGGAATTAAATTCAGAGAAGCATCGAC
TCATTAACTATCATCAGGAACAGGCAGTTAATTGCCTTTTGGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGACCTGTCACTAG
AAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCATTTGAAGAGATAGACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTT
CTGATGGCACACAATGGATGGGTAATGGGAGATGATCCTCTTCGAAACTTTGCTGAACCGGGTTCAGAAGTTTACCTAAGGAGAGAACTTATTTGCTGGG
GAGACAGTGTTAAATTACGCTATGGGAATAAACCAGAGGACTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCAACTTATTTCCA
GGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTCACGTAGCTGAGTACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCT
GAACTGTTCACAGGAAGTGAAGATCTGGACAATGTCTTTGTTACTAGACTGGGCATTAGTTCCTTAATAAGAGAGGCAATGAGTGCATATAATAGTCATG
AAGAGGGCAGATTAGTTTACCGATATGGAGGAGAACCTGTTGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCACATGCCCTGTT
TATGGATATTACGCATGATAATGAGTGTCCTATTGTGCATAGATCAGCGTATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGT
GGAAGTACAAGAGGCTATGATGAATTAGTGCCTCATCAGATTTCAGTGGTTTCTGAAGAACGGTTTTACACTAAGTGGAATCCTGAAGCATTGCCTTCAA
ACACAGGTGAAGTTAATTTCCAAAGCGGCATTATTGCAGCCAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTTATTCAGGTGTA
TGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAAGACACTCACCTAGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCC
AAGACTTCATTTTACAGCAAGGAAGTGCCTCAAATGTGCATCCCTGGCAAAATTGAAGAAGTAGTTCTTGAAGCTAGAACTATTGAGAGAAACACGAAAC
CTTATAGGAAGGATGAGAATTCAATCAATGGAACACCAGATATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATTGTTAAACAAGC
TGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAGAAATAGAATTTGAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCA
CATGCACAAGTCGCTGTTGGAATTCTTCGAAATCATCTGACACAATTCAGTCCTCACTTTAAATCTGGCAGCCTAGCTGTTGACAATGCAGATCCTATAT
TAAAAATTCCTTTTGCTTCTCTTGCCTCCAGATTAACTTTGGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAAGATGGTGGAGG
GTGCTATGACATACCAAACTGGTCAGCCCTTAAATATGCAGGTCTTCAAGGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCAT
CCTTTTTGTAATAATTTGAGATCTGGAGATTGGATGATTGACTATGTCAGTAACCGGCTTATTTCACGATCAGGAACTATTGCTGAAGTTGGTAAATGGT
TGCAGGCTATGTTCTTCTACCTGAAGCAGATCCCACGTTACCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACTCTTCTGGATAC
AGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTTCAACCTTTGTGAAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCT
TCCCTGCCAATTCTTTCACCTGCCCTAATGGATGTACCTTATAGGTTAAATGAGATCACAAAAGAAAAGGAGCAATGTTGTGTTTCTCTAGCTGCAGGCT
TACCTCATTTTTCTTCTGGTATTTTCCGCTGCTGGGGAAGGGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTATGTAGAAGCCAG
GAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATGGTCTCATTCCTAATCTACTGGGTGAAGGAATTTATGCCAGATACAATTGTCGGGATGCTGTG
TGGTGGTGGCTGCAGTGTATCCAGGATTACTGTAAAATGGTTCCAAATGGTCTAGACATTCTCAAGTGCCCAGTTTCCAGAATGTATCCTACAGATGATT
CTGCTCCTTTGCCTGCTGGCACACTGGATCAGCCATTGTTTGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTCCGAGAAAGGAA
TGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAGGTTTTAATATAACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTC
AATTGTGGCACATGGATGGATAAAATGGGAGAAAGTGACAGAGCTAGAAACAGAGGAATCCCAGCCACACCAAGAGATGGGTCTGCTGTGGAAATTGTGG
GCCTGAGTAAATCTGCTGTTCGCTGGTTGCTGGAATTATCCAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGAAAGGCTATAAA
GGTCTCATATGATGAGTGGAACAGAAAAATACAAGACAACTTTGAAAAGCTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAAT
CTGGTTCACAAACGTGGCATATACAAAGATAGTTATGGAGCTTCAAGTCCTTGGTGTGACTATCAGCTCAGGCCTAATTTTACCATAGCAATGGTTGTGG
CCCCTGAGCTCTTTACTACAGAAAAAGCATGGAAAGCTTTGGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTAGATCCAGATGA
TATGGTTTACTGTGGAATTTATGACAATGCATTAGACAATGACAACTACAATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCT
ATTGGGTATTTTCTTCGTGCAAAATTATATTTTTCCAGATTGATGGGCCCGGAGACTACTGCAAAGACTATAGTTTTGGTTAAAAATGTTCTTTCCCGAC
ATTATGTTCATCTTGAGAGATCCCCTTGGAAAGGACTTCCAGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACACAAGCCTGGTC
AATTGCTACTATTCTTGAGACACTTTATGATTTATAGTTTATTACAGATATTAAGTATGCAATTACTTGTATTATAGGATGCAAGGTCATCATATGTAAA
TGCCTTATATGCACAGGCTCAAGTTGTTTTAAAAATCTCATTTATTATAATATTGATGCTCAATTAGGTAAGATTGTAAAAGCATTGATTTTTTTTAATG
TACAGAGGTAGATTTCAATTTGAATCAGAAAGAAATATCATTACCAATGAAATGTGTTTGAGTTCAGTAAGAATTATTCAAATGCCTAGAAATCCATAGT
TTGGAAAAGAAAAATCATGTCATCTTCTATTTGTACAGAAATGAAAATAAAATATGAAAATAATGAAAGAAATGAAAAGATAGCTTTTAATTGTGGTATA
TATAATCTTCAGTAACAATACATACTGAATACGCTGTGGTTCATTAATATTAACACCACGTACTATAGTATTCTTAATACAGTGCTCACTGCATTTAATA
AATATTTAATAAATGATGAATGATAGAAGTTTCCATCTACAATATATGTTCCTAAATGGAGCACAGATGTTCAAACTATGCTTTCATTTTTTCACTGATA
TATTAATTTTTGTGTAATGAATGCCAACAGTATATTTTATATGATTTACTTATGTGAGGAAACATGCAAAGCATTAGGAAATTTATTTCCTAAAAACAGT
TTTGTAAAATTAGTATTGAGTTCTATTGAGTATTATAAGATAGCTTACATTTTCAAAATGGAAATTGTCGGTCATATTTCTAGAACTTTAAAGAAAAAAG
AATGTTATATTAGTTTTCTAAAACTCAACTATCTTTAGTCATGTTCAAAAATCTATTGCTAGATCATAGTAGATACTGGTTTTCTATTAACTCAAAACCT
ACATTGACAAGTTTAACATTGAGAAGAATCTTAACAAAAATATGGATATGAATTCAGTAGATATCTTAAATTCAATAAAATCACTGGAAGTTTTTCATGA
TAACTTATTTTAAGATGCCTTAAAAATCTTAAAGTCACAAAAGGAAAAAGGTTTTTAACATTTACATGAGTTAACATTTTTTCATAGAACTTATTTCCTA
GATAGAATTTTTTACTGTTTTTTACTGTTTTCTTAAGAAAACAGTTAAATCATTATGCATTCAGTTGGAAGAAAGTAGTGGCAAGAATTCTTTCATTGCT
ATATAATATTCAGTGGCTCATTTATACCTAATAAAATAATGGTATTTTAAAATAATGCTACTTTCAAAGTAGCATTTTTTTAGTTAGTTTACAGGTTACA
TACCCAAAACCTTAACTATGACTAAGAAATTAAAGAAGAAAACCAGCAAACTAAAACTTCTGGGCAGCAAAAATATATAAATGCTTCAGATGTCAAATAC
CCATGCTTGAAAGCTCGTGTAATTTACTTTAAGATTATCTGCCTGCTCTTCTTCAAAGCTGACCTTGCTTTAGAAATAGTTTTAACTAGCTTAGTTTTCT
GGTTTCCAAAACTAAAATAGATTAAATCCTACAAATTTAAGGACAGTTGTGACAGTAATCTGACCACTATCTATAAATACATTGGACATTGGTTTCCAAA
TCTCCCTTTCTTCTTCAGTTCCTTCCTTGTTCAATATATACCCTTCTCTAAACTGTGCGGGTAAAAGGAATGACTGTCCTTGAGAGAACCATTAGTTTAT
CAAAGGTTTATGTAGTTTTGTTGCTGTACCCTAACTTTGATATTCAGGGAGGTAGGAAAGGTAACAGAAAACCAGCATATTTAATCAAAGCAAGAAGTAA
TCGCTGACAGTTAAATGTGACCAAAAAAATTAAAAGTTCACAATTTTTTTAATGTAGCCATTTGGGGTTATCTCTAGTAAGGCAGATACCCACGTTGGTA
AATTTTTAGGATATTGTGTTGCACTAGAAAACTAAGTGGTTCATATTTCTAATGAGGAAGATTAATGAAAGAACATTGTTATATTCTGCGTGGTATATTT
TAAAGTTTAAGAAGGCATGTTAAACATTATTTCCTCTATGGTAGTTAAAATACAGAATTAGATTTTTAACAGGTGTCATTTGACTAAACGTTTCGGTAGA
ATGCTTCATACTTGAGTGATGCTGGATAAGGTATTGTATTTCAACAATGGACTATGCCTTGGTTTTTCACTAATCAAAATCAAAATTACTCTTTAACATG
ATAAATGAATTTACCAGTTTAGTATGCTGTGGTATTTTAATAAGTTTTCAAAGATAATTGGGAAAACATGAGACTGGTCATATTGATGAATATTGTAACA
TGTGAATTGTGATCCATTTCTGATATGTCTTGAACTACTGTGTCTAGTGGGCAAATGTCATTGTTACCTCTGTGTGTTAAGAAAATAAAAATATTTTCTA
AAGGTC
- refseq_AGL.F1 (forward primer)
- refseq_AGL.R1 (reverse primer)
- Single exon skipping
Frame 0
LSTAAIPEATTASLCSHLPIGGWRPEFGNGEIAHLLSLSRLIS*AKMGHSKQIRILLLNEMEKLEKT
LFRLEQGYELQFRLGPTLQGKAVTVYTNYPFPG
ETFNREKFRSLDWENPTEREDDSDKYCKLNLQQ
SGSFQYYFLQGNEKSGGGYIVVDPILRVGADNHV
LPLDCVTLQTFLAKCLGPFDEWESRLRVAKESG
YNMIHFTPLQTLGLSRSCYSLANQLELNPDFSR
PNRKYTWNDVGQLVEKLKKEWNVICITDVVYNHT
AANSKWIQEHPECAYNLVNSPHLKPAWVLDRAL
WRFSCDVAEGKYKEKGIPALIENDHHMNSIRKI
IWEDIFPKLKLWEFFQVDVNKAVEQFRRLLTQEN
RRVTKSDPNQHLTIIQDPEYRRFGCTVDMNIAL
TTFIPHDKGPAAIEECCNWFHKRMEELNSEKHR
LINYHQEQAVNCLLGNVFYERLAGHGPKLGPVTR
KHPLVTRYFTFPFEEIDFSMEESMIHLPNKACF
LMAHNGWVMGDDPLRNFAEPGSEVYLRRELICW
GDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQ
GVRLDNCHSTPLHVAEYMLDAARNLQPNLYVVA
ELFTGSEDLDNVFVTRLGISSLIREAMSAYNSH
EEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHALF
MDITHDNECPIVHRSAYDALPSTTIVSMACCAS
GSTRGYDELVPHQISVVSEERFYTKWNPEALPS
NTGEVNFQSGIIAARCAISKLHQELGAKGFIQVY
VDQVDEDIVAVTRHSPSIHQSVVAVSRTAFRNP
KTSFYSKEVPQMCIPGKIEEVVLEARTIERNTK
PYRKDENSINGTPDITVEIREHIQLNESKIVKQA
GVATKGPNEYIQEIEFENLSPGSVIIFRVSLDP
HAQVAVGILRNHLTQFSPHFKSGSLAVDNADPI
LKIPFASLASRLTLAELNQILYRCESEEKEDGGG
CYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGH
PFCNNLRSGDWMIDYVSNRLISRSGTIAEVGKW
LQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLDT
AWKQMSSFVQNGSTFVKHLSLGSVQLCGVGKFP
SLPILSPALMDVPYRLNEITKEKEQCCVSLAAG
LPHFSSGIFRCWGRDTFIALRGILLITGRYVEAR
NIILAFAGTLRHGLIPNLLGEGIYARYNCRDAV
WWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDD
SAPLPAGTLDQPLFEVIQEAMQKHMQGIQFRERN
AGPQIDRNMKDEGFNITAGVDEETGFVYGGNRF
NCGTWMDKMGESDRARNRGIPATPRDGSAVEIV
GLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAIK
VSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPN
LVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVV
APELFTTEKAWKALEIAEKKLLGPLGMKTLDPDD
MVYCGIYDNALDNDNYNLAKGFNYHQGPEWLWP
IGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSR
HYVHLERSPWKGLPELTNENAQYCPFSCETQAWS
IATILETLYDL*FITDIKYAITCIIGCKVIICK
CLICTGSSCFKNLIYYNIDAQLGKIVKALIFFN
VQR*ISI*IRKKYHYQ*NVFEFSKNYSNA*KSIV
WKRKIMSSSICTEMKIKYENNERNEKIAFNCGI
YNLQ*QYILNTLWFININTTYYSILNTVLTAFN
KYLINDE**KFPSTIYVPKWSTDVQTMLSFFH*Y
INFCVMNANSIFYMIYLCEETCKALGNLFPKNS
FVKLVLSSIEYYKIAYIFKMEIVGHISRTLKKK
ECYISFLKLNYL*SCSKIYC*IIVDTGFLLTQNL
H*QV*H*EES*QKYGYEFSRYLKFNKITGSFS*
*LILRCLKNLKVTKGKRFLTFT*VNIFS*NLFP
R*NFLLFFTVFLRKQLNHYAFSWKKVVARILSLL
YNIQWLIYT**NNGILK*CYFQSSIFLVSLQVT
YPKP*L*LRN*RRKPAN*NFWAAKIYKCFRCQI
PMLESSCNLL*DYLPALLQS*PCFRNSFN*LSFL
VSKTKID*ILQI*GQL*Q*SDHYL*IHWTLVSK
SPFLLQFLPCSIYTLL*TVRVKGMTVLERTISL
SKVYVVLLLYPNFDIQGGRKGNRKPAYLIKARSN
R*QLNVTKKIKSSQFF*CSHLGLSLVRQIPTLV
NF*DIVLH*KTKWFIFLMRKINERTLLYSAWYI
LKFKKAC*TLFPLW*LKYRIRFLTGVI*LNVSVE
CFILE*CWIRYCISTMDYALVFH*SKSKLLFNM
INEFTSLVCCGILISFQR*LGKHETGHIDEYCN
M*IVIHF*YVLNYCV*WANVIVTSVC*ENKNIF*
R
Frame 1
CLRQLFQRQQLLPSVLISPLVAGDPNLGMGRLPTCYL*AD*SLKPKWDTVNRFEFYF*TKWRNWKR
PSSDLNKGMSYSSD*AQLYREKQLPCIQITHFLE
KHLIEKNSVLWIGKIQQKEKMILINTVNLICNN
LVHFSIISFKEMRKVVEVT*LWTPFYVLVLIIM
CYPWTVLLFRHF*LSVWDLLMNGKADLGLQKNQA
TT*FILPHCRLLDYLGHATPLPIS*N*ILTFQD
LIESIPGMMLDS*WKN*KRNGMLFVLLMLSTII
LLLIVNGSRNIQNVPIIL*ILHT*NLPGS*TEHF
GVSPVMLQKGNTKKREYLL*LKMITI*IPSEK*
FGRIFFQSLNSGNFSK*MSTKRLSNLEDFLHKK
IGE*PSLIQTNTLRLFKILNTDGLAVL*I*TLH*
RLSYHMTRGQQQLKNAVIGFIKEWRN*IQRSID
SLTIIRNRQLIAFWEMCFMNDWLAMVQN*DLSL
ESIL*LPGILLSHLKR*TSPWKNL*FICQIKLVF
*WHTMDG*WEMILFETLLNRVQKFT*GENLFAG
ETVLNYAMGINQRTVLISGHT*KNTLK*LQLIS
REYVLITATQHLFT*LSTCWMLLGICNPIYM**L
NCSQEVKIWTMSLLLDWALVP**ERQ*VHIIVM
KRAD*FTDMEENLLDPLFSPV*GL*CQLLHMPC
LWILRMIMSVLLCIDQRMMLFQVLQLFLWHVVLV
EVQEAMMN*CLIRFQWFLKNGFTLSGILKHCLQ
TQVKLISKAALLQPGVLSVNFIRSLEPRVLFRC
MWIKLMKT*WQ*QDTHLASISLLWLYLELLSGIP
RLHFTARKCLKCASLAKLKK*FLKLELLRETRN
LIGRMRIQSMEHQISQ*KLENIFSLMKVKLLNK
LELPQKGPMNIFKK*NLKTCLQEVLLYSELVLIH
MHKSLLEFFEII*HNSVLTLNLAA*LLTMQILY
*KFLLLLLPPD*LWLS*IRSFTDVNQKKRKMVE
GAMTYQTGQPLNMQVFKV*CLYWQK*DQRMTWGI
LFVII*DLEIG*LTMSVTGLFHDQELLLKLVNG
CRLCSST*SRSHVTLSHVTLMLY*LVHIPLFWI
QHGSRCQALFRMVQPL*NTFHWVQFNCVE*ENSL
PCQFFHLP*WMYLIG*MRSQKKRSNVVFL*LQA
YLIFLLVFSAAGEGILLLHLEVYC*LLDAM*KP
GILF*HLRVP*GMVSFLIYWVKEFMPDTIVGMLC
GGGCSVSRITVKWFQMV*TFSSAQFPECILQMI
LLLCLLAHWISHCLKSYRKQCKNTCRAYSSEKG
MLVPR*IET*RTKVLI*LQELMKKQDLFMEEIVS
IVAHGWIKWEKVTELETEESQPHQEMGLLWKLW
A*VNLLFAGCWNYPKKIFSLIMKSQ*KDMERL*
RSHMMSGTEKYKTTLKSYFMFPKTLQI*MKSIQI
WFTNVAYTKIVMELQVLGVTISSGLILP*QWLW
PLSSLLQKKHGKLWRLQKKNCLVPLA*KL*IQM
IWFTVEFMTMH*TMTTTILLKVSIITKDLSGCGL
LGIFFVQNYIFPD*WARRLLQRL*FWLKMFFPD
IMFILRDPLGKDFQN*PMRMPSTVLSAVKHKPG
QLLLFLRHFMIYSLLQILSMQLLVL*DARSSYVN
ALYAQAQVVLKISFIIILMLN*VRL*KH*FFLM
YRGRFQFESERNIITNEMCLSSVRIIQMPRNP*
FGKEKSCHLLFVQK*K*NMKIMKEMKR*LLIVVY
IIFSNNTY*IRCGSLILTPRTIVFLIQCSLHLI
NI**MMNDRSFHLQYMFLNGAQMFKLCFHFFTD
ILIFV**MPTVYFI*FTYVRKHAKH*EIYFLKTV
L*N*Y*VLLSIIR*LTFSKWKLSVIFLEL*RKK
NVILVF*NSTIFSHVQKSIARS**ILVFY*LKT
YIDKFNIEKNLNKNMDMNSVDILNSIKSLEVFHD
NLF*DALKILKSQKEKGF*HLHELTFFHRTYFL
DRIFYCFLLFS*ENS*IIMHSVGRK*WQEFFHC
YIIFSGSFIPNKIMVF*NNATFKVAFF*LVYRLH
TQNLNYD*EIKEENQQTKTSGQQKYINASDVKY
PCLKARVIYFKIICLLFFKADLALEIVLTSLVF
WFPKLK*IKSYKFKDSCDSNLTTIYKYIGHWFPN
LPFFFSSFLVQYIPFSKLCG*KE*LSLREPLVY
QRFM*FCCCTLTLIFREVGKVTENQHI*SKQEV
IADS*M*PKKLKVHNFFNVAIWGYL**GRYPRW*
IFRILCCTRKLSGSYF**GRLMKEHCYILRGIF
*SLRRHVKHYFLYGS*NTELDF*QVSFD*TFR*
NASYLSDAG*GIVFQQWTMPWFFTNQNQNYSLT*
*MNLPV*YAVVF**VFKDNWENMRLVILMNIVT
CEL*SISDMS*TTVSSGQMSLLPLCVKKIKIFS
KG
Frame 2
VYGSYSRGNNCFPLFSSPHWWLATRIWEWGDCPPVIFEQTNLLSQNGTQ*TDSNFTSERNGETGKD
PLQT*TRV*ATVPIRPNFTGKSSYRVYKLPISW
RNI**RKIPFSGLGKSNRKRR*F**IL*T*SATI
WFISVLFPSRK*EKWWRLHSCGPHFTCWC**SC
ATLGLCYSSDIFS*VFGTF**MGKQT*GCKRIR
LQHDSFYPIADSWTI*VMLLPCQSVRIKS*LFKT
**KVYLE*CWTASGKIKKGMECYLYY*CCLQSY
CC***MDPGTSRMCL*SCEFSTLKTCLGLRQST
LAFLL*CCRREIQRKGNTCFD*K*SPYEFHPKNN
LGGYFSKA*TLGIFPSRCQQSG*AI*KTSYTRK
*ASNQV*SKPTPYDYSRS*IQTVWLYCRYEHCT
NDFHTT*QGASSN*RML*LVS*KNGGIKFREAST
H*LSSGTGS*LPFGKCVL*TTGWPWSKTRTCH*
KASFSYQVFYFPI*RDRLLHGRIYDSSAK*SLF
SDGTQWMGNGR*SSSKLC*TGFRSLPKERTYLLG
RQC*ITLWE*TRGLSLSLGTHEKIH*NNCNLFP
GSTS**LPLNTSSRS*VHVGCC*EFATQFICSS
*TVHRK*RSGQCLCY*TGH*FLNKRGNECI**S*
RGQISLPIWRRTCWILCSALFEAFNASYCTCPV
YGYYA***VSYCA*ISV*CSSKYYNCFYGMLC*
WKYKRL**ISASSDFSGF*RTVLH*VES*SIAFK
HR*S*FPKRHYCSQVCYQ*TSSGAWSQGFYSGV
CGSS**RHSGSNKTLT*HPSVCCGCI*NCFQES
QDFILQQGSASNVHPWQN*RSSS*S*NY*EKHET
L*EG*EFNQWNTRYHSRN*RTYSA**K*NC*TS
WSCHKRAQ*IYSRNRI*KLVSRKCYYIQS*S*S
TCTSRCWNSSKSSDTIQSSL*IWQPSC*QCRSYI
KNSFCFSCLQINFG*AKSDPLPM*IRRKGRWWR
VL*HTKLVSP*ICRSSRFNVCIGRNKTKE*LGA
SFL**FEIWRLDD*LCQ*PAYFTIRNYC*SW*MV
AGYVLLPEADPTLPYPMLL*CYINWCIYHSSGY
SMEADVKLCSEWFNLCETPFIGFSSTVWSRKIP
FPANSFTCPNGCTL*VK*DHKRKGAMLCFSSCRL
TSFFFWYFPLLGKGYFYCT*RYTADYWTLCRSQ
EYYFSICGYPEAWSHS*STG*RNLCQIQLSGCC
VVVAAVYPGLL*NGSKWSRHSQVPSFQNVSYR*F
CSFACWHTGSAIV*SHTGSNAKTHAGHTVPRKE
CWSPDRSKHEGRRF*YNCRS**RNRICLWRKSF
QLWHMDG*NGRK*QS*KQRNPSHTKRWVCCGNCG
PE*ICCSLVAGIIQKKYFPLS*SHSKKTWKGYK
GLI**VEQKNTRQL*KAISCFRRPFRFK*KASK
SGSQTWHIQR*LWSFKSLV*LSAQA*FYHSNGCG
P*ALYYRKSMESFGDCRKKIAWSPWHENFRSR*
YGLLWNL*QCIRQ*QLQSC*RFQLSPRT*VAVA
YWVFSSCKIIFFQIDGPGDYCKDYSFG*KCSFPT
LCSS*EIPLERTSRTDQ*ECPVLSFQL*NTSLV
NCYYS*DTL*FIVYYRY*VCNYLYYRMQGHHM*
MPYMHRLKLF*KSHLL*Y*CSIR*DCKSIDFF*C
TEVDFNLNQKEISLPMKCV*VQ*ELFKCLEIHS
LEKKNHVIFYLYRNENKI*K**KK*KDSF*LWY
I*SSVTIHTEYAVVH*Y*HHVL*YS*YSAHCI**
IFNK**MIEVSIYNICS*MEHRCSNYAFIFSLI
Y*FLCNECQQYILYDLLM*GNMQSIRKFIS*KQ
FCKISIEFY*VL*DSLHFQNGNCRSYF*NFKEKR
MLY*FSKTQLSLVMFKNLLLDHSRYWFSINSKP
TLTSLTLRRILTKIWI*IQ*IS*IQ*NHWKFFM
ITYFKMP*KS*SHKRKKVFNIYMS*HFFIELIS*
IEFFTVFYCFLKKTVKSLCIQLEESSGKNSFIA
I*YSVAHLYLIK*WYFKIMLLSK*HFFS*FTGY
IPKTLTMTKKLKKKTSKLKLLGSKNI*MLQMSNT
HA*KLV*FTLRLSACSSSKLTLL*K*F*LA*FS
GFQN*NRLNPTNLRTVVTVI*PLSINTLDIGFQ
ISLSSSVPSLFNIYPSLNCAGKRNDCP*ENH*FI
KGLCSFVAVP*L*YSGR*ER*QKTSIFNQSKK*
SLTVKCDQKN*KFTIFLM*PFGVISSKADTHVG
KFLGYCVALEN*VVHISNEED**KNIVIFCVVYF
KV*EGMLNIISSMVVKIQN*IFNRCHLTKRFGR
MLHT*VMLDKVLYFNNGLCLGFSLIKIKITL*H
DK*IYQFSMLWYFNKFSKIIGKT*DWSY**IL*H
VNCDPFLICLELLCLVGKCHCYLCVLRK*KYFL
KV
Sequence NM_000642
CCCGGAAGTGGGCCAGAGGTACGGTCCGCTCCCACCTGGGGCGAGTGCGCGCACGGCCAGGTTGGGTACCGGGTGCGCCCAGGAACCCGCGCGAGGCGAAGTCGCTGAGACTCTGCCTGCTTCTCACCCAGCTGCCTCGGCGCTGCCCCGGTCGCTCGCCGCCCCTCCCTTTGCCCTTCACGGCGCCCGGCCCTCCTTGG
GCTGCGGCTTCTGTGCGAGGCTGGGCAGCCAGCCCTTCCCCTTCTGTTTCTCCCCGTCCCCTCCCCCCGACCGTAGCACCAGAGTCGCGGGTCCTGCAGT
GCCCCAGAAGCCGCACGTATAACTCCCTCGGCGGGTAACTCATTCGACTGTGGAGTTCTTTTAATTCTTATGAAAGATTTCAAATCCTCTAGAAGCCAAA
ATGGGACACAGTAAACAGATTCGAATTTTACTTCTGAACGAAATGGAGAAACTGGAAAAGACCCTCTTCAGACTTGAACAAGGGTATGAGCTACAGTTCC
GATTAGGCCCAACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTTAATAGAGAAAAATTCCGTTCTCTGGATTG
GGAAAATCCAACAGAAAGAGAAGATGATTCTGATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTCAAGGAAATGAG
AAAAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCTGATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAG
CTAAGTGTTTGGGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATGATTCATTTTACCCCATTGCAGACTCTTGG
ACTATCTAGGTCATGCTACTCCCTTGCCAATCAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATGTTGGACAGCTA
GTGGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTCTACAATCATACTGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAAT
GTGCCTATAATCTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTCTCCTGTGATGTTGCAGAAGGGAAATACAA
AGAAAAGGGAATACCTGCTTTGATTGAAAATGATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTAAACTCTGGGAA
TTTTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTTACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTA
CGATTATTCAAGATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTCATACCACATGACAAGGGGCCAGCAGCAAT
TGAAGAATGCTGTAATTGGTTTCATAAAAGAATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAGTTAATTGCCTT
TTGGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGACCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCAT
TTGAAGAGATAGACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCACACAATGGATGGGTAATGGGAGATGATCC
TCTTCGAAACTTTGCTGAACCGGGTTCAGAAGTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGAATAAACCAGAG
GACTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCAACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTC
ACGTAGCTGAGTACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTCACAGGAAGTGAAGATCTGGACAATGTCTT
TGTTACTAGACTGGGCATTAGTTCCTTAATAAGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATGGAGGAGAACCT
GTTGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCACATGCCCTGTTTATGGATATTACGCATGATAATGAGTGTCCTATTGTGC
ATAGATCAGCGTATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACAAGAGGCTATGATGAATTAGTGCCTCATCA
GATTTCAGTGGTTTCTGAAGAACGGTTTTACACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCGGCATTATTGCA
GCCAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTTATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAA
GACACTCACCTAGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCATTTTACAGCAAGGAAGTGCCTCAAATGTG
CATCCCTGGCAAAATTGAAGAAGTAGTTCTTGAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCAATGGAACACCA
GATATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATTGTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAG
AAATAGAATTTGAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAAGTCGCTGTTGGAATTCTTCGAAATCATCT
GACACAATTCAGTCCTCACTTTAAATCTGGCAGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCTCCAGATTAACT
TTGGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAAGATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGCCCTTAAATATG
CAGGTCTTCAAGGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGTAATAATTTGAGATCTGGAGATTGGATGAT
TGACTATGTCAGTAACCGGCTTATTTCACGATCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGCAGATCCCACGT
TACCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACTCTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTT
CAACCTTTGTGAAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCAATTCTTTCACCTGCCCTAATGGATGTACC
TTATAGGTTAAATGAGATCACAAAAGAAAAGGAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCCGCTGCTGGGGA
AGGGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTATGTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATG
GTCTCATTCCTAATCTACTGGGTGAAGGAATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGGCTGCAGTGTATCCAGGATTACTGTAAAAT
GGTTCCAAATGGTCTAGACATTCTCAAGTGCCCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGGATCAGCCATTG
TTTGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTCCGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAG
GTTTTAATATAACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGCACATGGATGGATAAAATGGGAGAAAGTGA
CAGAGCTAGAAACAGAGGAATCCCAGCCACACCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGTTGCTGGAATTA
TCCAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGAAAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAAAATACAAGACA
ACTTTGAAAAGCTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCACAAACGTGGCATATACAAAGATAGTTATGG
AGCTTCAAGTCCTTGGTGTGACTATCAGCTCAGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAGCATGGAAAGCT
TTGGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTAGATCCAGATGATATGGTTTACTGTGGAATTTATGACAATGCATTAGACA
ATGACAACTACAATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTATTTTCTTCGTGCAAAATTATATTTTTCCAG
ATTGATGGGCCCGGAGACTACTGCAAAGACTATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTTGGAAAGGACTT
CCAGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACACAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTATGATTTATAGT
TTATTACAGATATTAAGTATGCAATTACTTGTATTATAGGATGCAAGGTCATCATATGTAAATGCCTTATATGCACAGGCTCAAGTTGTTTTAAAAATCT
CATTTATTATAATATTGATGCTCAATTAGGTAAGATTGTAAAAGCATTGATTTTTTTTAATGTACAGAGGTAGATTTCAATTTGAATCAGAAAGAAATAT
CATTACCAATGAAATGTGTTTGAGTTCAGTAAGAATTATTCAAATGCCTAGAAATCCATAGTTTGGAAAAGAAAAATCATGTCATCTTCTATTTGTACAG
AAATGAAAATAAAATATGAAAATAATGAAAGAAATGAAAAGATAGCTTTTAATTGTGGTATATATAATCTTCAGTAACAATACATACTGAATACGCTGTG
GTTCATTAATATTAACACCACGTACTATAGTATTCTTAATACAGTGCTCACTGCATTTAATAAATATTTAATAAATGATGAATGATAGAAGTTTCCATCT
ACAATATATGTTCCTAAATGGAGCACAGATGTTCAAACTATGCTTTCATTTTTTCACTGATATATTAATTTTTGTGTAATGAATGCCAACAGTATATTTT
ATATGATTTACTTATGTGAGGAAACATGCAAAGCATTAGGAAATTTATTTCCTAAAAACAGTTTTGTAAAATTAGTATTGAGTTCTATTGAGTATTATAA
GATAGCTTACATTTTCAAAATGGAAATTGTCGGTCATATTTCTAGAACTTTAAAGAAAAAAGAATGTTATATTAGTTTTCTAAAACTCAACTATCTTTAG
TCATGTTCAAAAATCTATTGCTAGATCATAGTAGATACTGGTTTTCTATTAACTCAAAACCTACATTGACAAGTTTAACATTGAGAAGAATCTTAACAAA
AATATGGATATGAATTCAGTAGATATCTTAAATTCAATAAAATCACTGGAAGTTTTTCATGATAACTTATTTTAAGATGCCTTAAAAATCTTAAAGTCAC
AAAAGGAAAAAGGTTTTTAACATTTACATGAGTTAACATTTTTTCATAGAACTTATTTCCTAGATAGAATTTTTTACTGTTTTTTACTGTTTTCTTAAGA
AAACAGTTAAATCATTATGCATTCAGTTGGAAGAAAGTAGTGGCAAGAATTCTTTCATTGCTATATAATATTCAGTGGCTCATTTATACCTAATAAAATA
ATGGTATTTTAAAATAATGCTACTTTCAAAGTAGCATTTTTTTAGTTAGTTTACAGGTTACATACCCAAAACCTTAACTATGACTAAGAAATTAAAGAAG
AAAACCAGCAAACTAAAACTTCTGGGCAGCAAAAATATATAAATGCTTCAGATGTCAAATACCCATGCTTGAAAGCTCGTGTAATTTACTTTAAGATTAT
CTGCCTGCTCTTCTTCAAAGCTGACCTTGCTTTAGAAATAGTTTTAACTAGCTTAGTTTTCTGGTTTCCAAAACTAAAATAGATTAAATCCTACAAATTT
AAGGACAGTTGTGACAGTAATCTGACCACTATCTATAAATACATTGGACATTGGTTTCCAAATCTCCCTTTCTTCTTCAGTTCCTTCCTTGTTCAATATA
TACCCTTCTCTAAACTGTGCGGGTAAAAGGAATGACTGTCCTTGAGAGAACCATTAGTTTATCAAAGGTTTATGTAGTTTTGTTGCTGTACCCTAACTTT
GATATTCAGGGAGGTAGGAAAGGTAACAGAAAACCAGCATATTTAATCAAAGCAAGAAGTAATCGCTGACAGTTAAATGTGACCAAAAAAATTAAAAGTT
CACAATTTTTTTAATGTAGCCATTTGGGGTTATCTCTAGTAAGGCAGATACCCACGTTGGTAAATTTTTAGGATATTGTGTTGCACTAGAAAACTAAGTG
GTTCATATTTCTAATGAGGAAGATTAATGAAAGAACATTGTTATATTCTGCGTGGTATATTTTAAAGTTTAAGAAGGCATGTTAAACATTATTTCCTCTA
TGGTAGTTAAAATACAGAATTAGATTTTTAACAGGTGTCATTTGACTAAACGTTTCGGTAGAATGCTTCATACTTGAGTGATGCTGGATAAGGTATTGTA
TTTCAACAATGGACTATGCCTTGGTTTTTCACTAATCAAAATCAAAATTACTCTTTAACATGATAAATGAATTTACCAGTTTAGTATGCTGTGGTATTTT
AATAAGTTTTCAAAGATAATTGGGAAAACATGAGACTGGTCATATTGATGAATATTGTAACATGTGAATTGTGATCCATTTCTGATATGTCTTGAACTAC
TGTGTCTAGTGGGCAAATGTCATTGTTACCTCTGTGTGTTAAGAAAATAAAAATATTTTCTAAAGGTC
- refseq_AGL.F1 (forward primer)
- refseq_AGL.R1 (reverse primer)
- Single exon skipping
Frame 0
PGSGPEVRSAPTWGECAHGQVGYRVRPGTRARRSR*DSACFSPSCLGAAPVARRPSLCPSRRPALLG
LRLLCEAGQPALPLLFLPVPSPRP*HQSRGSCS
APEAARITPSAGNSFDCGVLLILMKDFKSSRSQ
NGTQ*TDSNFTSERNGETGKDPLQT*TRV*ATVP
IRPNFTGKSSYRVYKLPISWRNI**RKIPFSGL
GKSNRKRR*F**IL*T*SATIWFISVLFPSRK*
EKWWRLHSCGPHFTCWC**SCATLGLCYSSDIFS
*VFGTF**MGKQT*GCKRIRLQHDSFYPIADSW
TI*VMLLPCQSVRIKS*LFKT**KVYLE*CWTA
SGKIKKGMECYLYY*CCLQSYCC***MDPGTSRM
CL*SCEFSTLKTCLGLRQSTLAFLL*CCRREIQ
RKGNTCFD*K*SPYEFHPKNNLGGYFSKA*TLG
IFPSRCQQSG*AI*KTSYTRK*ASNQV*SKPTPY
DYSRS*IQTVWLYCRYEHCTNDFHTT*QGASSN
*RML*LVS*KNGGIKFREASTH*LSSGTGS*LP
FGKCVL*TTGWPWSKTRTCH*KASFSYQVFYFPI
*RDRLLHGRIYDSSAK*SLFSDGTQWMGNGR*S
SSKLC*TGFRSLPKERTYLLGRQC*ITLWE*TR
GLSLSLGTHEKIH*NNCNLFPGSTS**LPLNTSS
RS*VHVGCC*EFATQFICSS*TVHRK*RSGQCL
CY*TGH*FLNKRGNECI**S*RGQISLPIWRRT
CWILCSALFEAFNASYCTCPVYGYYA***VSYCA
*ISV*CSSKYYNCFYGMLC*WKYKRL**ISASS
DFSGF*RTVLH*VES*SIAFKHR*S*FPKRHYC
SQVCYQ*TSSGAWSQGFYSGVCGSS**RHSGSNK
TLT*HPSVCCGCI*NCFQESQDFILQQGSASNV
HPWQN*RSSS*S*NY*EKHETL*EG*EFNQWNT
RYHSRN*RTYSA**K*NC*TSWSCHKRAQ*IYSR
NRI*KLVSRKCYYIQS*S*STCTSRCWNSSKSS
DTIQSSL*IWQPSC*QCRSYIKNSFCFSCLQIN
FG*AKSDPLPM*IRRKGRWWRVL*HTKLVSP*IC
RSSRFNVCIGRNKTKE*LGASFL**FEIWRLDD
*LCQ*PAYFTIRNYC*SW*MVAGYVLLPEADPT
LPYPMLL*CYINWCIYHSSGYSMEADVKLCSEWF
NLCETPFIGFSSTVWSRKIPFPANSFTCPNGCT
L*VK*DHKRKGAMLCFSSCRLTSFFFWYFPLLG
KGYFYCT*RYTADYWTLCRSQEYYFSICGYPEAW
SHS*STG*RNLCQIQLSGCCVVVAAVYPGLL*N
GSKWSRHSQVPSFQNVSYR*FCSFACWHTGSAI
V*SHTGSNAKTHAGHTVPRKECWSPDRSKHEGRR
F*YNCRS**RNRICLWRKSFQLWHMDG*NGRK*
QS*KQRNPSHTKRWVCCGNCGPE*ICCSLVAGI
IQKKYFPLS*SHSKKTWKGYKGLI**VEQKNTRQ
L*KAISCFRRPFRFK*KASKSGSQTWHIQR*LW
SFKSLV*LSAQA*FYHSNGCGP*ALYYRKSMES
FGDCRKKIAWSPWHENFRSR*YGLLWNL*QCIRQ
*QLQSC*RFQLSPRT*VAVAYWVFSSCKIIFFQ
IDGPGDYCKDYSFG*KCSFPTLCSS*EIPLERT
SRTDQ*ECPVLSFQL*NTSLVNCYYS*DTL*FIV
YYRY*VCNYLYYRMQGHHM*MPYMHRLKLF*KS
HLL*Y*CSIR*DCKSIDFF*CTEVDFNLNQKEI
SLPMKCV*VQ*ELFKCLEIHSLEKKNHVIFYLYR
NENKI*K**KK*KDSF*LWYI*SSVTIHTEYAV
VH*Y*HHVL*YS*YSAHCI**IFNK**MIEVSI
YNICS*MEHRCSNYAFIFSLIY*FLCNECQQYIL
YDLLM*GNMQSIRKFIS*KQFCKISIEFY*VL*
DSLHFQNGNCRSYF*NFKEKRMLY*FSKTQLSL
VMFKNLLLDHSRYWFSINSKPTLTSLTLRRILTK
IWI*IQ*IS*IQ*NHWKFFMITYFKMP*KS*SH
KRKKVFNIYMS*HFFIELIS*IEFFTVFYCFLK
KTVKSLCIQLEESSGKNSFIAI*YSVAHLYLIK*
WYFKIMLLSK*HFFS*FTGYIPKTLTMTKKLKK
KTSKLKLLGSKNI*MLQMSNTHA*KLV*FTLRL
SACSSSKLTLL*K*F*LA*FSGFQN*NRLNPTNL
RTVVTVI*PLSINTLDIGFQISLSSSVPSLFNI
YPSLNCAGKRNDCP*ENH*FIKGLCSFVAVP*L
*YSGR*ER*QKTSIFNQSKK*SLTVKCDQKN*KF
TIFLM*PFGVISSKADTHVGKFLGYCVALEN*V
VHISNEED**KNIVIFCVVYFKV*EGMLNIISS
MVVKIQN*IFNRCHLTKRFGRMLHT*VMLDKVLY
FNNGLCLGFSLIKIKITL*HDK*IYQFSMLWYF
NKFSKIIGKT*DWSY**IL*HVNCDPFLICLEL
LCLVGKCHCYLCVLRK*KYFLKV
Frame 1
PEVGQRYGPLPPGASARTARLGTGCAQEPARGEVAETLPASHPAASALPRSLAAPPFALHGARPSL
GCGFCARLGSQPFPFCFSPSPPPDRSTRVAGPAV
PQKPHV*LPRRVTHSTVEFF*FL*KISNPLEAK
MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQF
RLGPTLQGKAVTVYTNYPFPGETFNREKFRSLDW
ENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNE
KSGGGYIVVDPILRVGADNHVLPLDCVTLQTFL
AKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLG
LSRSCYSLANQLELNPDFSRPNRKYTWNDVGQL
VEKLKKEWNVICITDVVYNHTAANSKWIQEHPE
CAYNLVNSPHLKPAWVLDRALWRFSCDVAEGKYK
EKGIPALIENDHHMNSIRKIIWEDIFPKLKLWE
FFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHL
TIIQDPEYRRFGCTVDMNIALTTFIPHDKGPAAI
EECCNWFHKRMEELNSEKHRLINYHQEQAVNCL
LGNVFYERLAGHGPKLGPVTRKHPLVTRYFTFP
FEEIDFSMEESMIHLPNKACFLMAHNGWVMGDDP
LRNFAEPGSEVYLRRELICWGDSVKLRYGNKPE
DCPYLWAHMKKYTEITATYFQGVRLDNCHSTPL
HVAEYMLDAARNLQPNLYVVAELFTGSEDLDNVF
VTRLGISSLIREAMSAYNSHEEGRLVYRYGGEP
VGSFVQPCLRPLMPAIAHALFMDITHDNECPIV
HRSAYDALPSTTIVSMACCASGSTRGYDELVPHQ
ISVVSEERFYTKWNPEALPSNTGEVNFQSGIIA
ARCAISKLHQELGAKGFIQVYVDQVDEDIVAVT
RHSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMC
IPGKIEEVVLEARTIERNTKPYRKDENSINGTP
DITVEIREHIQLNESKIVKQAGVATKGPNEYIQ
EIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHL
TQFSPHFKSGSLAVDNADPILKIPFASLASRLT
LAELNQILYRCESEEKEDGGGCYDIPNWSALKY
AGLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMI
DYVSNRLISRSGTIAEVGKWLQAMFFYLKQIPR
YLIPCYFDAILIGAYTTLLDTAWKQMSSFVQNG
STFVKHLSLGSVQLCGVGKFPSLPILSPALMDVP
YRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWG
RDTFIALRGILLITGRYVEARNIILAFAGTLRH
GLIPNLLGEGIYARYNCRDAVWWWLQCIQDYCKM
VPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPL
FEVIQEAMQKHMQGIQFRERNAGPQIDRNMKDE
GFNITAGVDEETGFVYGGNRFNCGTWMDKMGESD
RARNRGIPATPRDGSAVEIVGLSKSAVRWLLEL
SKKNIFPYHEVTVKRHGKAIKVSYDEWNRKIQD
NFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYG
ASSPWCDYQLRPNFTIAMVVAPELFTTEKAWKA
LEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALD
NDNYNLAKGFNYHQGPEWLWPIGYFLRAKLYFSR
LMGPETTAKTIVLVKNVLSRHYVHLERSPWKGL
PELTNENAQYCPFSCETQAWSIATILETLYDL*
FITDIKYAITCIIGCKVIICKCLICTGSSCFKNL
IYYNIDAQLGKIVKALIFFNVQR*ISI*IRKKY
HYQ*NVFEFSKNYSNA*KSIVWKRKIMSSSICT
EMKIKYENNERNEKIAFNCGIYNLQ*QYILNTLW
FININTTYYSILNTVLTAFNKYLINDE**KFPS
TIYVPKWSTDVQTMLSFFH*YINFCVMNANSIF
YMIYLCEETCKALGNLFPKNSFVKLVLSSIEYYK
IAYIFKMEIVGHISRTLKKKECYISFLKLNYL*
SCSKIYC*IIVDTGFLLTQNLH*QV*H*EES*Q
KYGYEFSRYLKFNKITGSFS**LILRCLKNLKVT
KGKRFLTFT*VNIFS*NLFPR*NFLLFFTVFLR
KQLNHYAFSWKKVVARILSLLYNIQWLIYT**N
NGILK*CYFQSSIFLVSLQVTYPKP*L*LRN*RR
KPAN*NFWAAKIYKCFRCQIPMLESSCNLL*DY
LPALLQS*PCFRNSFN*LSFLVSKTKID*ILQI
*GQL*Q*SDHYL*IHWTLVSKSPFLLQFLPCSIY
TLL*TVRVKGMTVLERTISLSKVYVVLLLYPNF
DIQGGRKGNRKPAYLIKARSNR*QLNVTKKIKS
SQFF*CSHLGLSLVRQIPTLVNF*DIVLH*KTKW
FIFLMRKINERTLLYSAWYILKFKKAC*TLFPL
W*LKYRIRFLTGVI*LNVSVECFILE*CWIRYC
ISTMDYALVFH*SKSKLLFNMINEFTSLVCCGIL
ISFQR*LGKHETGHIDEYCNM*IVIHF*YVLNY
CV*WANVIVTSVC*ENKNIF*R
Frame 2
RKWARGTVRSHLGRVRARPGWVPGAPRNPREAKSLRLCLLLTQLPRRCPGRSPPLPLPFTAPGPPW
AAASVRGWAASPSPSVSPRPLPPTVAPESRVLQ
CPRSRTYNSLGG*LIRLWSSFNSYERFQIL*KPK
WDTVNRFEFYF*TKWRNWKRPSSDLNKGMSYSS
D*AQLYREKQLPCIQITHFLEKHLIEKNSVLWI
GKIQQKEKMILINTVNLICNNLVHFSIISFKEMR
KVVEVT*LWTPFYVLVLIIMCYPWTVLLFRHF*
LSVWDLLMNGKADLGLQKNQATT*FILPHCRLL
DYLGHATPLPIS*N*ILTFQDLIESIPGMMLDS*
WKN*KRNGMLFVLLMLSTIILLLIVNGSRNIQN
VPIIL*ILHT*NLPGS*TEHFGVSPVMLQKGNT
KKREYLL*LKMITI*IPSEK*FGRIFFQSLNSGN
FSK*MSTKRLSNLEDFLHKKIGE*PSLIQTNTL
RLFKILNTDGLAVL*I*TLH*RLSYHMTRGQQQ
LKNAVIGFIKEWRN*IQRSIDSLTIIRNRQLIAF
WEMCFMNDWLAMVQN*DLSLESIL*LPGILLSH
LKR*TSPWKNL*FICQIKLVF*WHTMDG*WEMI
LFETLLNRVQKFT*GENLFAGETVLNYAMGINQR
TVLISGHT*KNTLK*LQLISREYVLITATQHLF
T*LSTCWMLLGICNPIYM**LNCSQEVKIWTMS
LLLDWALVP**ERQ*VHIIVMKRAD*FTDMEENL
LDPLFSPV*GL*CQLLHMPCLWILRMIMSVLLC
IDQRMMLFQVLQLFLWHVVLVEVQEAMMN*CLI
RFQWFLKNGFTLSGILKHCLQTQVKLISKAALLQ
PGVLSVNFIRSLEPRVLFRCMWIKLMKT*WQ*Q
DTHLASISLLWLYLELLSGIPRLHFTARKCLKC
ASLAKLKK*FLKLELLRETRNLIGRMRIQSMEHQ
ISQ*KLENIFSLMKVKLLNKLELPQKGPMNIFK
K*NLKTCLQEVLLYSELVLIHMHKSLLEFFEII
*HNSVLTLNLAA*LLTMQILY*KFLLLLLPPD*L
WLS*IRSFTDVNQKKRKMVEGAMTYQTGQPLNM
QVFKV*CLYWQK*DQRMTWGILFVII*DLEIG*
LTMSVTGLFHDQELLLKLVNGCRLCSST*SRSHV
TLSHVTLMLY*LVHIPLFWIQHGSRCQALFRMV
QPL*NTFHWVQFNCVE*ENSLPCQFFHLP*WMY
LIG*MRSQKKRSNVVFL*LQAYLIFLLVFSAAGE
GILLLHLEVYC*LLDAM*KPGILF*HLRVP*GM
VSFLIYWVKEFMPDTIVGMLCGGGCSVSRITVK
WFQMV*TFSSAQFPECILQMILLLCLLAHWISHC
LKSYRKQCKNTCRAYSSEKGMLVPR*IET*RTK
VLI*LQELMKKQDLFMEEIVSIVAHGWIKWEKV
TELETEESQPHQEMGLLWKLWA*VNLLFAGCWNY
PKKIFSLIMKSQ*KDMERL*RSHMMSGTEKYKT
TLKSYFMFPKTLQI*MKSIQIWFTNVAYTKIVM
ELQVLGVTISSGLILP*QWLWPLSSLLQKKHGKL
WRLQKKNCLVPLA*KL*IQMIWFTVEFMTMH*T
MTTTILLKVSIITKDLSGCGLLGIFFVQNYIFP
D*WARRLLQRL*FWLKMFFPDIMFILRDPLGKDF
QN*PMRMPSTVLSAVKHKPGQLLLFLRHFMIYS
LLQILSMQLLVL*DARSSYVNALYAQAQVVLKI
SFIIILMLN*VRL*KH*FFLMYRGRFQFESERNI
ITNEMCLSSVRIIQMPRNP*FGKEKSCHLLFVQ
K*K*NMKIMKEMKR*LLIVVYIIFSNNTY*IRC
GSLILTPRTIVFLIQCSLHLINI**MMNDRSFHL
QYMFLNGAQMFKLCFHFFTDILIFV**MPTVYF
I*FTYVRKHAKH*EIYFLKTVL*N*Y*VLLSII
R*LTFSKWKLSVIFLEL*RKKNVILVF*NSTIFS
HVQKSIARS**ILVFY*LKTYIDKFNIEKNLNK
NMDMNSVDILNSIKSLEVFHDNLF*DALKILKS
QKEKGF*HLHELTFFHRTYFLDRIFYCFLLFS*E
NS*IIMHSVGRK*WQEFFHCYIIFSGSFIPNKI
MVF*NNATFKVAFF*LVYRLHTQNLNYD*EIKE
ENQQTKTSGQQKYINASDVKYPCLKARVIYFKII
CLLFFKADLALEIVLTSLVFWFPKLK*IKSYKF
KDSCDSNLTTIYKYIGHWFPNLPFFFSSFLVQY
IPFSKLCG*KE*LSLREPLVYQRFM*FCCCTLTL
IFREVGKVTENQHI*SKQEVIADS*M*PKKLKV
HNFFNVAIWGYL**GRYPRW*IFRILCCTRKLS
GSYF**GRLMKEHCYILRGIF*SLRRHVKHYFLY
GS*NTELDF*QVSFD*TFR*NASYLSDAG*GIV
FQQWTMPWFFTNQNQNYSLT**MNLPV*YAVVF
**VFKDNWENMRLVILMNIVTCEL*SISDMS*TT
VSSGQMSLLPLCVKKIKIFSKG
Sequence NM_000646
GGGTAACTCATTCGACTGTGGAGTTCTTTTAATTCTTATGAAAGATTTCAAATCCTCTAGAAGCCAAAATGGGACACAGTAAACAGATTCGAATTTTACTTCTGAACGAAATGGAGAAACTGGAAAAGACCCTCTTCAGACTTGAACAAGAAACTGGGTCTCACTATGTTGCCCAGGTTGATATTGAACTCCTGGACTCA
AGCAACCCTCCCTCTTTGGCCTCTGAAAGTACTGGGATTACAAGCATAAGCCACCGGGCATGGCCCCAATTCTGAGCATTAATTTATTTATTGGGTATGA
GCTACAGTTCCGATTAGGCCCAACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTTAATAGAGAAAAATTCCGT
TCTCTGGATTGGGAAAATCCAACAGAAAGAGAAGATGATTCTGATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTC
AAGGAAATGAGAAAAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCTGATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCA
GACATTTTTAGCTAAGTGTTTGGGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATGATTCATTTTACCCCATTG
CAGACTCTTGGACTATCTAGGTCATGCTACTCCCTTGCCAATCAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATG
TTGGACAGCTAGTGGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTCTACAATCATACTGCTGCTAATAGTAAATGGATCCAGGA
ACATCCAGAATGTGCCTATAATCTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTCTCCTGTGATGTTGCAGAA
GGGAAATACAAAGAAAAGGGAATACCTGCTTTGATTGAAAATGATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTA
AACTCTGGGAATTTTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTTACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAA
CCAACACCTTACGATTATTCAAGATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTCATACCACATGACAAGGGG
CCAGCAGCAATTGAAGAATGCTGTAATTGGTTTCATAAAAGAATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAG
TTAATTGCCTTTTGGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGACCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTT
TACTTTCCCATTTGAAGAGATAGACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCACACAATGGATGGGTAATG
GGAGATGATCCTCTTCGAAACTTTGCTGAACCGGGTTCAGAAGTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGA
ATAAACCAGAGGACTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCAACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTC
AACACCTCTTCACGTAGCTGAGTACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTCACAGGAAGTGAAGATCTG
GACAATGTCTTTGTTACTAGACTGGGCATTAGTTCCTTAATAAGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATG
GAGGAGAACCTGTTGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCACATGCCCTGTTTATGGATATTACGCATGATAATGAGTG
TCCTATTGTGCATAGATCAGCGTATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACAAGAGGCTATGATGAATTA
GTGCCTCATCAGATTTCAGTGGTTTCTGAAGAACGGTTTTACACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCG
GCATTATTGCAGCCAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTTATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGT
GGCAGTAACAAGACACTCACCTAGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCATTTTACAGCAAGGAAGTG
CCTCAAATGTGCATCCCTGGCAAAATTGAAGAAGTAGTTCTTGAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCA
ATGGAACACCAGATATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATTGTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGA
ATATATTCAAGAAATAGAATTTGAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAAGTCGCTGTTGGAATTCTT
CGAAATCATCTGACACAATTCAGTCCTCACTTTAAATCTGGCAGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCT
CCAGATTAACTTTGGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAAGATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGC
CCTTAAATATGCAGGTCTTCAAGGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGTAATAATTTGAGATCTGGA
GATTGGATGATTGACTATGTCAGTAACCGGCTTATTTCACGATCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGC
AGATCCCACGTTACCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACTCTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGT
TCAGAATGGTTCAACCTTTGTGAAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCAATTCTTTCACCTGCCCTA
ATGGATGTACCTTATAGGTTAAATGAGATCACAAAAGAAAAGGAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCC
GCTGCTGGGGAAGGGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTATGTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTAC
CCTGAGGCATGGTCTCATTCCTAATCTACTGGGTGAAGGAATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGGCTGCAGTGTATCCAGGAT
TACTGTAAAATGGTTCCAAATGGTCTAGACATTCTCAAGTGCCCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGG
ATCAGCCATTGTTTGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTCCGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACAT
GAAGGACGAAGGTTTTAATATAACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGCACATGGATGGATAAAATG
GGAGAAAGTGACAGAGCTAGAAACAGAGGAATCCCAGCCACACCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGT
TGCTGGAATTATCCAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGAAAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAA
AATACAAGACAACTTTGAAAAGCTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCACAAACGTGGCATATACAAA
GATAGTTATGGAGCTTCAAGTCCTTGGTGTGACTATCAGCTCAGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAG
CATGGAAAGCTTTGGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTAGATCCAGATGATATGGTTTACTGTGGAATTTATGACAA
TGCATTAGACAATGACAACTACAATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTATTTTCTTCGTGCAAAATTA
TATTTTTCCAGATTGATGGGCCCGGAGACTACTGCAAAGACTATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTT
GGAAAGGACTTCCAGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACACAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTA
TGATTTATAGTTTATTACAGATATTAAGTATGCAATTACTTGTATTATAGGATGCAAGGTCATCATATGTAAATGCCTTATATGCACAGGCTCAAGTTGT
TTTAAAAATCTCATTTATTATAATATTGATGCTCAATTAGGTAAGATTGTAAAAGCATTGATTTTTTTTAATGTACAGAGGTAGATTTCAATTTGAATCA
GAAAGAAATATCATTACCAATGAAATGTGTTTGAGTTCAGTAAGAATTATTCAAATGCCTAGAAATCCATAGTTTGGAAAAGAAAAATCATGTCATCTTC
TATTTGTACAGAAATGAAAATAAAATATGAAAATAATGAAAGAAATGAAAAGATAGCTTTTAATTGTGGTATATATAATCTTCAGTAACAATACATACTG
AATACGCTGTGGTTCATTAATATTAACACCACGTACTATAGTATTCTTAATACAGTGCTCACTGCATTTAATAAATATTTAATAAATGATGAATGATAGA
AGTTTCCATCTACAATATATGTTCCTAAATGGAGCACAGATGTTCAAACTATGCTTTCATTTTTTCACTGATATATTAATTTTTGTGTAATGAATGCCAA
CAGTATATTTTATATGATTTACTTATGTGAGGAAACATGCAAAGCATTAGGAAATTTATTTCCTAAAAACAGTTTTGTAAAATTAGTATTGAGTTCTATT
GAGTATTATAAGATAGCTTACATTTTCAAAATGGAAATTGTCGGTCATATTTCTAGAACTTTAAAGAAAAAAGAATGTTATATTAGTTTTCTAAAACTCA
ACTATCTTTAGTCATGTTCAAAAATCTATTGCTAGATCATAGTAGATACTGGTTTTCTATTAACTCAAAACCTACATTGACAAGTTTAACATTGAGAAGA
ATCTTAACAAAAATATGGATATGAATTCAGTAGATATCTTAAATTCAATAAAATCACTGGAAGTTTTTCATGATAACTTATTTTAAGATGCCTTAAAAAT
CTTAAAGTCACAAAAGGAAAAAGGTTTTTAACATTTACATGAGTTAACATTTTTTCATAGAACTTATTTCCTAGATAGAATTTTTTACTGTTTTTTACTG
TTTTCTTAAGAAAACAGTTAAATCATTATGCATTCAGTTGGAAGAAAGTAGTGGCAAGAATTCTTTCATTGCTATATAATATTCAGTGGCTCATTTATAC
CTAATAAAATAATGGTATTTTAAAATAATGCTACTTTCAAAGTAGCATTTTTTTAGTTAGTTTACAGGTTACATACCCAAAACCTTAACTATGACTAAGA
AATTAAAGAAGAAAACCAGCAAACTAAAACTTCTGGGCAGCAAAAATATATAAATGCTTCAGATGTCAAATACCCATGCTTGAAAGCTCGTGTAATTTAC
TTTAAGATTATCTGCCTGCTCTTCTTCAAAGCTGACCTTGCTTTAGAAATAGTTTTAACTAGCTTAGTTTTCTGGTTTCCAAAACTAAAATAGATTAAAT
CCTACAAATTTAAGGACAGTTGTGACAGTAATCTGACCACTATCTATAAATACATTGGACATTGGTTTCCAAATCTCCCTTTCTTCTTCAGTTCCTTCCT
TGTTCAATATATACCCTTCTCTAAACTGTGCGGGTAAAAGGAATGACTGTCCTTGAGAGAACCATTAGTTTATCAAAGGTTTATGTAGTTTTGTTGCTGT
ACCCTAACTTTGATATTCAGGGAGGTAGGAAAGGTAACAGAAAACCAGCATATTTAATCAAAGCAAGAAGTAATCGCTGACAGTTAAATGTGACCAAAAA
AATTAAAAGTTCACAATTTTTTTAATGTAGCCATTTGGGGTTATCTCTAGTAAGGCAGATACCCACGTTGGTAAATTTTTAGGATATTGTGTTGCACTAG
AAAACTAAGTGGTTCATATTTCTAATGAGGAAGATTAATGAAAGAACATTGTTATATTCTGCGTGGTATATTTTAAAGTTTAAGAAGGCATGTTAAACAT
TATTTCCTCTATGGTAGTTAAAATACAGAATTAGATTTTTAACAGGTGTCATTTGACTAAACGTTTCGGTAGAATGCTTCATACTTGAGTGATGCTGGAT
AAGGTATTGTATTTCAACAATGGACTATGCCTTGGTTTTTCACTAATCAAAATCAAAATTACTCTTTAACATGATAAATGAATTTACCAGTTTAGTATGC
TGTGGTATTTTAATAAGTTTTCAAAGATAATTGGGAAAACATGAGACTGGTCATATTGATGAATATTGTAACATGTGAATTGTGATCCATTTCTGATATG
TCTTGAACTACTGTGTCTAGTGGGCAAATGTCATTGTTACCTCTGTGTGTTAAGAAAATAAAAATATTTTCTAAAGGTC
- refseq_AGL.F1 (forward primer)
- refseq_AGL.R1 (reverse primer)
- Single exon skipping
Frame 0
G*LIRLWSSFNSYERFQIL*KPKWDTVNRFEFYF*TKWRNWKRPSSDLNKKLGLTMLPRLILNSWTQ
ATLPLWPLKVLGLQA*ATGHGPNSEH*FIYWV*
ATVPIRPNFTGKSSYRVYKLPISWRNI**RKIP
FSGLGKSNRKRR*F**IL*T*SATIWFISVLFPS
RK*EKWWRLHSCGPHFTCWC**SCATLGLCYSS
DIFS*VFGTF**MGKQT*GCKRIRLQHDSFYPI
ADSWTI*VMLLPCQSVRIKS*LFKT**KVYLE*C
WTASGKIKKGMECYLYY*CCLQSYCC***MDPG
TSRMCL*SCEFSTLKTCLGLRQSTLAFLL*CCR
REIQRKGNTCFD*K*SPYEFHPKNNLGGYFSKA*
TLGIFPSRCQQSG*AI*KTSYTRK*ASNQV*SK
PTPYDYSRS*IQTVWLYCRYEHCTNDFHTT*QG
ASSN*RML*LVS*KNGGIKFREASTH*LSSGTGS
*LPFGKCVL*TTGWPWSKTRTCH*KASFSYQVF
YFPI*RDRLLHGRIYDSSAK*SLFSDGTQWMGN
GR*SSSKLC*TGFRSLPKERTYLLGRQC*ITLWE
*TRGLSLSLGTHEKIH*NNCNLFPGSTS**LPL
NTSSRS*VHVGCC*EFATQFICSS*TVHRK*RS
GQCLCY*TGH*FLNKRGNECI**S*RGQISLPIW
RRTCWILCSALFEAFNASYCTCPVYGYYA***V
SYCA*ISV*CSSKYYNCFYGMLC*WKYKRL**I
SASSDFSGF*RTVLH*VES*SIAFKHR*S*FPKR
HYCSQVCYQ*TSSGAWSQGFYSGVCGSS**RHS
GSNKTLT*HPSVCCGCI*NCFQESQDFILQQGS
ASNVHPWQN*RSSS*S*NY*EKHETL*EG*EFNQ
WNTRYHSRN*RTYSA**K*NC*TSWSCHKRAQ*
IYSRNRI*KLVSRKCYYIQS*S*STCTSRCWNS
SKSSDTIQSSL*IWQPSC*QCRSYIKNSFCFSCL
QINFG*AKSDPLPM*IRRKGRWWRVL*HTKLVS
P*ICRSSRFNVCIGRNKTKE*LGASFL**FEIW
RLDD*LCQ*PAYFTIRNYC*SW*MVAGYVLLPEA
DPTLPYPMLL*CYINWCIYHSSGYSMEADVKLC
SEWFNLCETPFIGFSSTVWSRKIPFPANSFTCP
NGCTL*VK*DHKRKGAMLCFSSCRLTSFFFWYFP
LLGKGYFYCT*RYTADYWTLCRSQEYYFSICGY
PEAWSHS*STG*RNLCQIQLSGCCVVVAAVYPG
LL*NGSKWSRHSQVPSFQNVSYR*FCSFACWHTG
SAIV*SHTGSNAKTHAGHTVPRKECWSPDRSKH
EGRRF*YNCRS**RNRICLWRKSFQLWHMDG*N
GRK*QS*KQRNPSHTKRWVCCGNCGPE*ICCSLV
AGIIQKKYFPLS*SHSKKTWKGYKGLI**VEQK
NTRQL*KAISCFRRPFRFK*KASKSGSQTWHIQ
R*LWSFKSLV*LSAQA*FYHSNGCGP*ALYYRKS
MESFGDCRKKIAWSPWHENFRSR*YGLLWNL*Q
CIRQ*QLQSC*RFQLSPRT*VAVAYWVFSSCKI
IFFQIDGPGDYCKDYSFG*KCSFPTLCSS*EIPL
ERTSRTDQ*ECPVLSFQL*NTSLVNCYYS*DTL
*FIVYYRY*VCNYLYYRMQGHHM*MPYMHRLKL
F*KSHLL*Y*CSIR*DCKSIDFF*CTEVDFNLNQ
KEISLPMKCV*VQ*ELFKCLEIHSLEKKNHVIF
YLYRNENKI*K**KK*KDSF*LWYI*SSVTIHT
EYAVVH*Y*HHVL*YS*YSAHCI**IFNK**MIE
VSIYNICS*MEHRCSNYAFIFSLIY*FLCNECQ
QYILYDLLM*GNMQSIRKFIS*KQFCKISIEFY
*VL*DSLHFQNGNCRSYF*NFKEKRMLY*FSKTQ
LSLVMFKNLLLDHSRYWFSINSKPTLTSLTLRR
ILTKIWI*IQ*IS*IQ*NHWKFFMITYFKMP*K
S*SHKRKKVFNIYMS*HFFIELIS*IEFFTVFYC
FLKKTVKSLCIQLEESSGKNSFIAI*YSVAHLY
LIK*WYFKIMLLSK*HFFS*FTGYIPKTLTMTK
KLKKKTSKLKLLGSKNI*MLQMSNTHA*KLV*FT
LRLSACSSSKLTLL*K*F*LA*FSGFQN*NRLN
PTNLRTVVTVI*PLSINTLDIGFQISLSSSVPS
LFNIYPSLNCAGKRNDCP*ENH*FIKGLCSFVAV
P*L*YSGR*ER*QKTSIFNQSKK*SLTVKCDQK
N*KFTIFLM*PFGVISSKADTHVGKFLGYCVAL
EN*VVHISNEED**KNIVIFCVVYFKV*EGMLNI
ISSMVVKIQN*IFNRCHLTKRFGRMLHT*VMLD
KVLYFNNGLCLGFSLIKIKITL*HDK*IYQFSM
LWYFNKFSKIIGKT*DWSY**IL*HVNCDPFLIC
LELLCLVGKCHCYLCVLRK*KYFLKV
Frame 1
GNSFDCGVLLILMKDFKSSRSQNGTQ*TDSNFTSERNGETGKDPLQT*TRNWVSLCCPG*Y*TPGL
KQPSLFGL*KYWDYKHKPPGMAPILSINLFIGYE
LQFRLGPTLQGKAVTVYTNYPFPGETFNREKFR
SLDWENPTEREDDSDKYCKLNLQQSGSFQYYFL
QGNEKSGGGYIVVDPILRVGADNHVLPLDCVTLQ
TFLAKCLGPFDEWESRLRVAKESGYNMIHFTPL
QTLGLSRSCYSLANQLELNPDFSRPNRKYTWND
VGQLVEKLKKEWNVICITDVVYNHTAANSKWIQE
HPECAYNLVNSPHLKPAWVLDRALWRFSCDVAE
GKYKEKGIPALIENDHHMNSIRKIIWEDIFPKL
KLWEFFQVDVNKAVEQFRRLLTQENRRVTKSDPN
QHLTIIQDPEYRRFGCTVDMNIALTTFIPHDKG
PAAIEECCNWFHKRMEELNSEKHRLINYHQEQA
VNCLLGNVFYERLAGHGPKLGPVTRKHPLVTRYF
TFPFEEIDFSMEESMIHLPNKACFLMAHNGWVM
GDDPLRNFAEPGSEVYLRRELICWGDSVKLRYG
NKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHS
TPLHVAEYMLDAARNLQPNLYVVAELFTGSEDL
DNVFVTRLGISSLIREAMSAYNSHEEGRLVYRY
GGEPVGSFVQPCLRPLMPAIAHALFMDITHDNEC
PIVHRSAYDALPSTTIVSMACCASGSTRGYDEL
VPHQISVVSEERFYTKWNPEALPSNTGEVNFQS
GIIAARCAISKLHQELGAKGFIQVYVDQVDEDIV
AVTRHSPSIHQSVVAVSRTAFRNPKTSFYSKEV
PQMCIPGKIEEVVLEARTIERNTKPYRKDENSI
NGTPDITVEIREHIQLNESKIVKQAGVATKGPNE
YIQEIEFENLSPGSVIIFRVSLDPHAQVAVGIL
RNHLTQFSPHFKSGSLAVDNADPILKIPFASLA
SRLTLAELNQILYRCESEEKEDGGGCYDIPNWSA
LKYAGLQGLMSVLAEIRPKNDLGHPFCNNLRSG
DWMIDYVSNRLISRSGTIAEVGKWLQAMFFYLK
QIPRYLIPCYFDAILIGAYTTLLDTAWKQMSSFV
QNGSTFVKHLSLGSVQLCGVGKFPSLPILSPAL
MDVPYRLNEITKEKEQCCVSLAAGLPHFSSGIF
RCWGRDTFIALRGILLITGRYVEARNIILAFAGT
LRHGLIPNLLGEGIYARYNCRDAVWWWLQCIQD
YCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTL
DQPLFEVIQEAMQKHMQGIQFRERNAGPQIDRNM
KDEGFNITAGVDEETGFVYGGNRFNCGTWMDKM
GESDRARNRGIPATPRDGSAVEIVGLSKSAVRW
LLELSKKNIFPYHEVTVKRHGKAIKVSYDEWNRK
IQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYK
DSYGASSPWCDYQLRPNFTIAMVVAPELFTTEK
AWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDN
ALDNDNYNLAKGFNYHQGPEWLWPIGYFLRAKL
YFSRLMGPETTAKTIVLVKNVLSRHYVHLERSP
WKGLPELTNENAQYCPFSCETQAWSIATILETLY
DL*FITDIKYAITCIIGCKVIICKCLICTGSSC
FKNLIYYNIDAQLGKIVKALIFFNVQR*ISI*I
RKKYHYQ*NVFEFSKNYSNA*KSIVWKRKIMSSS
ICTEMKIKYENNERNEKIAFNCGIYNLQ*QYIL
NTLWFININTTYYSILNTVLTAFNKYLINDE**
KFPSTIYVPKWSTDVQTMLSFFH*YINFCVMNAN
SIFYMIYLCEETCKALGNLFPKNSFVKLVLSSI
EYYKIAYIFKMEIVGHISRTLKKKECYISFLKL
NYL*SCSKIYC*IIVDTGFLLTQNLH*QV*H*EE
S*QKYGYEFSRYLKFNKITGSFS**LILRCLKN
LKVTKGKRFLTFT*VNIFS*NLFPR*NFLLFFT
VFLRKQLNHYAFSWKKVVARILSLLYNIQWLIYT
**NNGILK*CYFQSSIFLVSLQVTYPKP*L*LR
N*RRKPAN*NFWAAKIYKCFRCQIPMLESSCNL
L*DYLPALLQS*PCFRNSFN*LSFLVSKTKID*I
LQI*GQL*Q*SDHYL*IHWTLVSKSPFLLQFLP
CSIYTLL*TVRVKGMTVLERTISLSKVYVVLLL
YPNFDIQGGRKGNRKPAYLIKARSNR*QLNVTKK
IKSSQFF*CSHLGLSLVRQIPTLVNF*DIVLH*
KTKWFIFLMRKINERTLLYSAWYILKFKKAC*T
LFPLW*LKYRIRFLTGVI*LNVSVECFILE*CWI
RYCISTMDYALVFH*SKSKLLFNMINEFTSLVC
CGILISFQR*LGKHETGHIDEYCNM*IVIHF*Y
VLNYCV*WANVIVTSVC*ENKNIF*R
Frame 2
VTHSTVEFF*FL*KISNPLEAKMGHSKQIRILLLNEMEKLEKTLFRLEQETGSHYVAQVDIELLDS
SNPPSLASESTGITSISHRAWPQF*ALIYLLGM
SYSSD*AQLYREKQLPCIQITHFLEKHLIEKNSV
LWIGKIQQKEKMILINTVNLICNNLVHFSIISF
KEMRKVVEVT*LWTPFYVLVLIIMCYPWTVLLF
RHF*LSVWDLLMNGKADLGLQKNQATT*FILPHC
RLLDYLGHATPLPIS*N*ILTFQDLIESIPGMM
LDS*WKN*KRNGMLFVLLMLSTIILLLIVNGSR
NIQNVPIIL*ILHT*NLPGS*TEHFGVSPVMLQK
GNTKKREYLL*LKMITI*IPSEK*FGRIFFQSL
NSGNFSK*MSTKRLSNLEDFLHKKIGE*PSLIQ
TNTLRLFKILNTDGLAVL*I*TLH*RLSYHMTRG
QQQLKNAVIGFIKEWRN*IQRSIDSLTIIRNRQ
LIAFWEMCFMNDWLAMVQN*DLSLESIL*LPGI
LLSHLKR*TSPWKNL*FICQIKLVF*WHTMDG*W
EMILFETLLNRVQKFT*GENLFAGETVLNYAMG
INQRTVLISGHT*KNTLK*LQLISREYVLITAT
QHLFT*LSTCWMLLGICNPIYM**LNCSQEVKIW
TMSLLLDWALVP**ERQ*VHIIVMKRAD*FTDM
EENLLDPLFSPV*GL*CQLLHMPCLWILRMIMS
VLLCIDQRMMLFQVLQLFLWHVVLVEVQEAMMN*
CLIRFQWFLKNGFTLSGILKHCLQTQVKLISKA
ALLQPGVLSVNFIRSLEPRVLFRCMWIKLMKT*
WQ*QDTHLASISLLWLYLELLSGIPRLHFTARKC
LKCASLAKLKK*FLKLELLRETRNLIGRMRIQS
MEHQISQ*KLENIFSLMKVKLLNKLELPQKGPM
NIFKK*NLKTCLQEVLLYSELVLIHMHKSLLEFF
EII*HNSVLTLNLAA*LLTMQILY*KFLLLLLP
PD*LWLS*IRSFTDVNQKKRKMVEGAMTYQTGQ
PLNMQVFKV*CLYWQK*DQRMTWGILFVII*DLE
IG*LTMSVTGLFHDQELLLKLVNGCRLCSST*S
RSHVTLSHVTLMLY*LVHIPLFWIQHGSRCQAL
FRMVQPL*NTFHWVQFNCVE*ENSLPCQFFHLP*
WMYLIG*MRSQKKRSNVVFL*LQAYLIFLLVFS
AAGEGILLLHLEVYC*LLDAM*KPGILF*HLRV
P*GMVSFLIYWVKEFMPDTIVGMLCGGGCSVSRI
TVKWFQMV*TFSSAQFPECILQMILLLCLLAHW
ISHCLKSYRKQCKNTCRAYSSEKGMLVPR*IET
*RTKVLI*LQELMKKQDLFMEEIVSIVAHGWIKW
EKVTELETEESQPHQEMGLLWKLWA*VNLLFAG
CWNYPKKIFSLIMKSQ*KDMERL*RSHMMSGTE
KYKTTLKSYFMFPKTLQI*MKSIQIWFTNVAYTK
IVMELQVLGVTISSGLILP*QWLWPLSSLLQKK
HGKLWRLQKKNCLVPLA*KL*IQMIWFTVEFMT
MH*TMTTTILLKVSIITKDLSGCGLLGIFFVQNY
IFPD*WARRLLQRL*FWLKMFFPDIMFILRDPL
GKDFQN*PMRMPSTVLSAVKHKPGQLLLFLRHF
MIYSLLQILSMQLLVL*DARSSYVNALYAQAQVV
LKISFIIILMLN*VRL*KH*FFLMYRGRFQFES
ERNIITNEMCLSSVRIIQMPRNP*FGKEKSCHL
LFVQK*K*NMKIMKEMKR*LLIVVYIIFSNNTY*
IRCGSLILTPRTIVFLIQCSLHLINI**MMNDR
SFHLQYMFLNGAQMFKLCFHFFTDILIFV**MP
TVYFI*FTYVRKHAKH*EIYFLKTVL*N*Y*VLL
SIIR*LTFSKWKLSVIFLEL*RKKNVILVF*NS
TIFSHVQKSIARS**ILVFY*LKTYIDKFNIEK
NLNKNMDMNSVDILNSIKSLEVFHDNLF*DALKI
LKSQKEKGF*HLHELTFFHRTYFLDRIFYCFLL
FS*ENS*IIMHSVGRK*WQEFFHCYIIFSGSFI
PNKIMVF*NNATFKVAFF*LVYRLHTQNLNYD*E
IKEENQQTKTSGQQKYINASDVKYPCLKARVIY
FKIICLLFFKADLALEIVLTSLVFWFPKLK*IK
SYKFKDSCDSNLTTIYKYIGHWFPNLPFFFSSFL
VQYIPFSKLCG*KE*LSLREPLVYQRFM*FCCC
TLTLIFREVGKVTENQHI*SKQEVIADS*M*PK
KLKVHNFFNVAIWGYL**GRYPRW*IFRILCCTR
KLSGSYF**GRLMKEHCYILRGIF*SLRRHVKH
YFLYGS*NTELDF*QVSFD*TFR*NASYLSDAG
*GIVFQQWTMPWFFTNQNQNYSLT**MNLPV*YA
VVF**VFKDNWENMRLVILMNIVTCEL*SISDM
S*TTVSSGQMSLLPLCVKKIKIFSKG
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