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Sequences

Sequence NM_178427

ATCTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCC
CACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCA
GCCATTGCCTCTGGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATG
GAGAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGGGAAAATCACAGTGAAATTGAACGGCGGCG
ACGGAACAAGATGACAGCCTACATCACAGAACTGTCAGATATGGTACCCACCTGTAGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATG
GCAGTTTCTCACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCTCCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTGA
TCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGTGGTGTATGTGTCTGACTCCGTGACTCCTGTTTTGAACCAGCCACA
GTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGATAAACTTCGTGAGCAGCTTTCCACTTCAGAAAATGCCCTGACAGGG
CGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCATGAGAATGTGTATGGGCTCAAGGAGATCGTTTATTTGCCGAATGA
GGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAGGAACAGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACC
TCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCAGCAGGTGTTTCCCTCCCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAG
TTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGTTCTCCCAACTGTACAGACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACA
ACATTGAGGGTATCTTCACTTTTGTGGATCACCGCTGTGTGGCTACTGTTGGCTACCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCA
TCCTGAAGACCAGCAGCTTCTAAGAGACAGCTTCCAACAGGTAGTGAAATTAAAAGGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAA
GAATGGCTCTGGATGAGAACCAGCTCCTTTACTTTCCAGAACCCTTACTCAGATGAAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCTA
GCCAAGAACCACGGCCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCCCACAGCTAATTTACCCCTGGAGATGGGCTCAGGACAGCTGGCACC
CAGGCAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTGGCCAGCTACAATCATTCCCAGGTGGTTCAGCCTGTGACAACCACA
GGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATAGAGATCCAAGATTTTCAGAAATCTATCACAACATCAATGCGGATC
AGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCAGGGCAACACATTCCCTCCTACCCCCCGGCCGGCAGAGAATTTCAG
GAATAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCTGCAGGACAGATGTTGGCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGA
GCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTTTCTGCCCAGCAGGTGGCTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGG
GCAGCTTTCAGACTCCATCCTCCTTCAGCTCCATGTCCCTCCCTGGTGCCCCAACTGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGG
ATCTAACTTTGCTCCTGAGACTGGACAGACTGCAGGACAATTCCAGACACGGACAGCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCT
CATCATCGTTCAAGTTCTAGTGAGCAACATGTTCAACAACCGCCAGCACAGCAACCTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGAG
ATCAGAGCAACAGCTACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAGGGGTGGGGGAG
AAAAAATCACTGTTTGTTTTTAAAAAGCAAATCTTTCTGTAAACAGAATAAAAGTTCCTCTCCCTTCCCTTCCCTCACCCCTGACATGTACCCCCTTTCC
CTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGTAACATTTATAGAAGAAATGGAATGAATCTCCAAGGCTTTTAGGACTGTCTGAAAATTTGAGG
CTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGACCTGAAATTGTATAGTGTTGATTTGTGCTGAGATCAAGAGGCAGGTTAGAAGAACCTGACAT
CCACTGTTTGCCTTGGATAGTATGGCTTGTTTTTGGAAAGAAATTCTGAAGAGAGTGGAGGAGAGGAGAAATGTCCTCATATTTGAGGACCATGAAACAT
TGTAGGTATATATGGGGCTTTAGCAAGTTTGAGCATAGGCTCTTTTTGCTGCCTGTGAGCAGTCCCTCTGGAAAGAAACATGTGAGTAAGTGAGAGAGAG
TGTGTGTGTATGTGTGTGTGTGTGTGTGTGCGCACACATGCTTCTGTATTTCACTCTTTCTCCCTATTAGGGAGTTATGCAAAATTTGTCCCCGATTTTA
CCTTTGTCTTTCTGTGTACTTTTCAAAGAGTCCTAAGGAGTTAAATCTTCCAGGTATTTTCCACTTAGTATTGCAGCCAAAGAATATTTAAATAAACGTC
TTTGCTGCGCTTGCATCCATGCCCAGCCAATATACAACTGTAAAGCAAATATAGAAAGTCGGCTGTTGATACGATTGTCTGTTATCGAACACATTCAGTG
ATAAAGCTGGGTTACTGCTGCTTTTGGTGCTCTCACCTTATCTGGAAGATCTGCAAACATTACCTAAATAGGCTGGCAAGATAAACACTTTCTGGAACCC
GAGACTTGGCCATAAAGATAATGCTGCATTTTTCTGTCAGAATCACATATGATGTGTGTTCTGTAGAGGTTATTTCTGCATGGAAACTCAACTTCTTGGA
TTAGCCGTCCCAGTGAAAATCCTCATTGTTGGAGTGTAAACCAAATACGAAGCCCTCTTGCAAAGTAGCCTCTTTCATCCCATACTCAAAATACCCAGTT
TAGCAAGCAACTGAGATTTAAGTCTCTCTGGCCCTAAGAGGTTTTTCCTCTTTGCTCCCTCCAATCTTGAGATTGGGTTTTGCTTTAGAGTGCAAGTATC
ATAATTCCGTATGATAGATGGGGCCTGGACACCCATCTCAACAGGGTCACTTGGTAATTAACAATAGCCATATAAATGCGGATACAGGTTACTACCCTCA
CCCTTTACCTTCCTCAGGTAACAGTCGTAGATACCAGCTTTTTTTTTTTTTTTTTTAAATTGGCTTTGGCCAGTAGCTAAAGTGCAAGACTGAATTAATG
AGAAGATATATTAAATGTAGTCATAGGGGACTGAGGAGCAAGGGTGGCCTTGAAGAGGCCAAAGGAATGTCCATTTGCTGAGTTTCCCTTCCTTATGTCT
CCAGTCTGGTGCCAGGTAGTGGAGTAAAAAAGGAGACAGTTTATTTTTTTATTCTATGTGCACACTTACAGTATACATATATATTTATATCACAATTTAC
GAAACCAAAAAGTTGAGTTTCCAATGGAACCCTTGTTTTTTAATAATCGACTTTTTAAATGTGATCAGGACTATAATATTGTACAGTTATTATAGGGCTT
TTGGGGAAGGGGAGGATAGCGAGAAGATGCTCTGGGGGTTTTGTTTTTGCTTTTCCTTCAGGGTTTTATTTTTGACTGTTTTGTTTTCTTGTTGGCCATT
TCTGTATTGCTGGCATCTGTGCTAAGCTTTACAGTGGCAAAAATAATGACATGTAGCAAAGATTTTCAAACAAAATATTTTTTCCTTTTGTAAAATTTCT
TGTGTTGTGTGATCTTGATTGCGGCTTTATCATTCCTTTCCAGTTCATAAACAACAGGCACCCACAACCAGAGGAATCTATAGTTTAAGCTCCAGACATA
CAAACATAAGGCACATTGTGTCTTTAATTTCAGGAATCAGAAATCATAGGGTTCTGATCACATTGCACGCCTCCCCCCTCACTTGTCCTCCTGATCCTGA
CACATTCTGAGTAACATCAGCAGGAATGCTCTGACCATGAGGTGGGGGTTTTGGGGTGGGCGTTGCCTGGGTTCTTGGGAGAGAGGGGAAGAGTCGGGAC
TTGAAAACCACTAGGGCACATCTGGATGCCTTCCCCCAGTATGTCCTTTTCTGGATTAAAATGAGTGAAATTTAAACTG
  • refseq_ARNT.F1 (forward primer)
  • refseq_ARNT.R1 (reverse primer)
  • Single exon skipping

Frame 0

ILDSAVAEAAVRRRFWGVAFLFPSLPVRWRRLL
PLGGGVARRRWHLRPWRRLLPTPK*HQMYHHWVQ
PLPLETLDLEFKVEEPLSRGLLSGDQGWILMMM
EKGTVNF*GVMMIRCLTIRSGLPGKITVKLNGG
DGTR*QPTSQNCQIWYPPVVPWLENQTS*PSYAW
QFLT*SPCGELATHPLMAPISRLSSLIRN*NI*
SWRQQMAFCLLSHVRQAGWCMCLTP*LLF*TSH
SLNGLAAHSMIRCTQMMWINFVSSFPLQKMP*QG
VSWI*RLEQ*KRKVSSLP*ECVWAQGDRLFAE*
GVAVALWTQFL*IG*AL*GTDAGMDLAL*RMGN
LTSWWSTAQATSRPGPQQVFPSQMMTQRLAREAS
FA*WPLADCR*LVLPTVQT*VMFVNQQSSSPDT
TLRVSSLLWITAVWLLLATSHRNS*ERIL*NSV
ILKTSSF*ETASNR**N*KAKCCLSCSGSGLRTK
NGSG*EPAPLLSRTLTQMKLSTSSVPTPM*RTL
AKNHGLHSPTQSRGHN*VPQLIYPWRWAQDSWH
PGSSNSKQNWTWYQEEMDWPATIIPRWFSL*QPQ
DQNTASPLRSQMVYLPRIEIQDFQKSITTSMRI
RVKASPPALSLPPNSYSPRATHSLLPPGRQRIS
GIVA*PLL*PLSSHQLLQDRCWPRFPATPTPPKE
QPQLGPLLPAQAFLPSRWLPRLLLRLVLPSLVW
AAFRLHPPSAPCPSLVPQLHRLVLLPTLVSPIV
DLTLLLRLDRLQDNSRHGQQRVWVSGHSGRASSL
IIVQVLVSNMFNNRQHSNLASLRSSRRCCPCWE
IRATATTMKNSLI*LCFPPFQNRTIGVRIRGGG
EKITVCF*KANLSVNRIKVPLPSLPSPLTCTPFP
FWLFPCSVASLR*HL*KKWNESPRLLGLSENLR
LGEVKTPFLMSPDLKLYSVDLC*DQEAG*KNLT
STVCLG*YGLFLERNSEESGGEEKCPHI*GP*NI
VGIYGALASLSIGSFCCL*AVPLERNM*VSERE
CVCMCVCVCVRTHASVFHSFSLLGSYAKFVPDF
TFVFLCTFQRVLRS*IFQVFST*YCSQRIFK*TS
LLRLHPCPANIQL*SKYRKSAVDTIVCYRTHSV
IKLGYCCFWCSHLIWKICKHYLNRLAR*TLSGT
RDLAIKIMLHFSVRITYDVCSVEVISAWKLNFLD
*PSQ*KSSLLECKPNTKPSCKVASFIPYSKYPV
*QATEI*VSLALRGFSSLLPPILRLGFALECKY
HNSV**MGPGHPSQQGHLVINNSHINADTGYYPH
PLPSSGNSRRYQLFFFFF*IGFGQ*LKCKTELM
RRYIKCSHRGLRSKGGLEEAKGMSIC*VSLPYV
SSLVPGSGVKKETVYFFILCAHLQYTYIFISQFT
KPKS*VSNGTLVF**STF*M*SGL*YCTVIIGL
LGKGRIARRCSGGFVFAFPSGFYF*LFCFLVGH
FCIAGICAKLYSGKNNDM*QRFSNKIFFPFVKFL
VLCDLDCGFIIPFQFINNRHPQPEESIV*APDI
QT*GTLCL*FQESEIIGF*SHCTPPPSLVLLIL
THSE*HQQECSDHEVGVLGWALPGFLGERGRVGT
*KPLGHIWMPSPSMSFSGLK*VKFKL

Frame 1

SWIPR*RRRRSGAASGEWPFFSPPSRFGGGGSS
HWGGGWRGGGGICGHGGDYCQPRNDIRCTITGS
SHCLWKLWTWNSRWRSHCPEGY*AATRAGF***W
RREQ*IFEV***SDV*R*GAVCQGKSQ*N*TAA
TEQDDSLHHRTVRYGTHL*CPGSKTRQANHLTH
GSFSHEVLAGNWQHIH*WLL*AVFPH*SGTETFD
LGGSRWLSVYCLM*DRQGGVCV*LRDSCFEPAT
V*MVWQHTL*SGAPR*CG*TS*AAFHFRKCPDR
AYPGSKDWNSEKGRSAVFHENVYGLKEIVYLPNE
VWQ*LCGPSFCE*AELCEEQMQEWTWLCKGWGT
SLRGGPLHRLHQGLAPSRCFPPR**PRGWPGKQ
VLPSGHWQIAGN*FSQLYRHE*CLSTNRVHLPTQ
H*GYLHFCGSPLCGYCWLPATGTLRKEYCRILS
S*RPAASKRQLPTGSEIKRPSAVCHVPVPV*EP
RMALDENQLLYFPEPLLR*N*VHHLYQHQCEEL*
PRTTAYTLQHNPEATTRSHS*FTPGDGLRTAGT
QAAATANRIGHGTRKRWTGQLQSFPGGSACDNH
RTRTQQAP*EVRWFICPG*RSKIFRNLSQHQCGS
E*RHLLQHCPCHPTAILPGQHIPSYPPAGREFQ
E*WPSPSCNHCPAISFCRTDVGPDFPPLQPHPR
SNPNLDPYYPLRLFCPAGGYPGYC*DSYFPVWCG
QLSDSILLQLHVPPWCPNCIAWCCCLP*SHQSW
I*LCS*DWTDCRTIPDTDSRGCGCLATVAGPAA
SSSFKF**ATCSTTASTATWPA*GLPGDAVHAGR
SEQQLQQ*RIP*SNYVSPLFRIELLG*G*GVGE
KKSLFVFKKQIFL*TE*KFLSLPFPHP*HVPPF
PSGCSPALLPL*GNIYRRNGMNLQGF*DCLKI*G
WVKLKHLSLCLLT*NCIVLICAEIKRQVRRT*H
PLFALDSMACFWKEILKRVEERRNVLIFEDHET
L*VYMGL*QV*A*ALFAACEQSLWKETCE*VRES
VCVCVCVCVCAHMLLYFTLSPY*GVMQNLSPIL
PLSFCVLFKES*GVKSSRYFPLSIAAKEYLNKR
LCCACIHAQPIYNCKANIESRLLIRLSVIEHIQ*
*SWVTAAFGALTLSGRSANIT*IGWQDKHFLEP
ETWP*R*CCIFLSESHMMCVL*RLFLHGNSTSW
ISRPSENPHCWSVNQIRSPLAK*PLSSHTQNTQF
SKQLRFKSLWP*EVFPLCSLQS*DWVLL*SASI
IIPYDRWGLDTHLNRVTW*LTIAI*MRIQVTTL
TLYLPQVTVVDTSFFFFFFKLALASS*SARLN**
EDILNVVIGD*GARVALKRPKECPFAEFPFLMS
PVWCQVVE*KRRQFIFLFYVHTYSIHIYLYHNL
RNQKVEFPMEPLFFNNRLFKCDQDYNIVQLL*GF
WGRGG*REDALGVLFLLFLQGFIFDCFVFLLAI
SVLLASVLSFTVAKIMTCSKDFQTKYFFLL*NF
LCCVILIAALSFLSSS*TTGTHNQRNL*FKLQTY
KHKAHCVFNFRNQKS*GSDHIARLPPHLSS*S*
HILSNISRNALTMRWGFWGGRCLGSWERGEESG
LENH*GTSGCLPPVCPFLD*NE*NLN

Frame 2

LGFRGSGGGGQAPLLGSGLSFPLPPGSVAAAPP
TGGGGGAAAVASAAMAATTANPEMTSDVPSLGP
AIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDD
GEGNSKFLRCDDDQMSNDKERFARENHSEIERRR
RNKMTAYITELSDMVPTCSALARKPDKLTILRM
AVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHL
ILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQ
SEWFGSTLYDQVHPDDVDKLREQLSTSENALTG
RILDLKTGTVKKEGQQSSMRMCMGSRRSFICRM
RCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEP
HFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK
FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRH
NIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCH
PEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQ
EWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNS
SQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAP
RQQQQQTELDMVPGRDGLASYNHSQVVQPVTTT
GPEHSKPLEKSDGLFAQDRDPRFSEIYHNINAD
QSKGISSSTVPATQQLFSQGNTFPPTPRPAENFR
NSGLAPPVTIVQPSASAGQMLAQISRHSNPTQG
ATPTWTPTTRSGFSAQQVATQATAKTRTSQFGV
GSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRG
SNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQP
HHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLG
DQSNSYNNEEFPDLTMFPPFSE*NYWGEDKGWGR
KNHCLFLKSKSFCKQNKSSSPFPSLTPDMYPLS
LLAVPLLCCLSKVTFIEEME*ISKAFRTV*KFE
AG*S*NTFPYVS*PEIV*C*FVLRSRGRLEEPDI
HCLPWIVWLVFGKKF*REWRRGEMSSYLRTMKH
CRYIWGFSKFEHRLFLLPVSSPSGKKHVSK*ER
VCVYVCVCVCAHTCFCISLFLPIRELCKICPRFY
LCLSVYFSKSPKELNLPGIFHLVLQPKNI*INV
FAALASMPSQYTTVKQI*KVGC*YDCLLSNTFS
DKAGLLLLLVLSPYLEDLQTLPK*AGKINTFWNP
RLGHKDNAAFFCQNHI*CVFCRGYFCMETQLLG
LAVPVKILIVGV*TKYEALLQSSLFHPILKIPS
LASN*DLSLSGPKRFFLFAPSNLEIGFCFRVQVS
*FRMIDGAWTPISTGSLGN*Q*PYKCGYRLLPS
PFTFLR*QS*IPAFFFFFLNWLWPVAKVQD*IN
EKIY*M*S*GTEEQGWP*RGQRNVHLLSFPSLCL
QSGAR*WSKKGDSLFFYSMCTLTVYIYIYITIY
ETKKLSFQWNPCFLIIDFLNVIRTIILYSYYRA
FGEGEDSEKMLWGFCFCFSFRVLFLTVLFSCWPF
LYCWHLC*ALQWQK**HVAKIFKQNIFSFCKIS
CVV*S*LRLYHSFPVHKQQAPTTRGIYSLSSRH
TNIRHIVSLISGIRNHRVLITLHASPLTCPPDPD
TF*VTSAGML*P*GGGFGVGVAWVLGREGKSRD
LKTTRAHLDAFPQYVLFWIKMSEI*T

Sequence NM_001668

ATCTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCC
CACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCA
GCCATTGCCTCTGGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATG
GAGAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGGTCGGATGATGAGCAGAGCTCTGCGGATAA
AGAGAGACTTGCCAGGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCCTACATCACAGAACTGTCAGATATGGTACCCACCTGT
AGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCTCACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCT
CCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTGATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGT
GGTGTATGTGTCTGACTCCGTGACTCCTGTTTTGAACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGAT
AAACTTCGTGAGCAGCTTTCCACTTCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCA
TGAGAATGTGTATGGGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAG
GAACAGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCAGCAGGT
GTTTCCCTCCCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAGTTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGTTCTCCCAACTGTACAG
ACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACAACATTGAGGGTATCTTCACTTTTGTGGATCACCGCTGTGTGGCTACTGTTGGCTA
CCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCATCCTGAAGACCAGCAGCTTCTAAGAGACAGCTTCCAACAGGTAGTGAAATTAAAA
GGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAAGAATGGCTCTGGATGAGAACCAGCTCCTTTACTTTCCAGAACCCTTACTCAGATG
AAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCTAGCCAAGAACCACGGCCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCC
CACAGCTAATTTACCCCTGGAGATGGGCTCAGGACAGCTGGCACCCAGGCAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTG
GCCAGCTACAATCATTCCCAGGTGGTTCAGCCTGTGACAACCACAGGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATA
GAGATCCAAGATTTTCAGAAATCTATCACAACATCAATGCGGATCAGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCA
GGGCAACACATTCCCTCCTACCCCCCGGCCGGCAGAGAATTTCAGGAATAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCTGCAGGA
CAGATGTTGGCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGAGCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTTTCTGCCCAGCAGGTGG
CTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGGGCAGCTTTCAGACTCCATCCTCCTTCAGCTCCATGTCCCTCCCTGGTGCCCCAAC
TGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGGATCTAACTTTGCTCCTGAGACTGGACAGACTGCAGGACAATTCCAGACACGGACA
GCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCTCATCATCGTTCAAGTTCTAGTGAGCAACATGTTCAACAACCGCCAGCACAGCAAC
CTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGAGATCAGAGCAACAGCTACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCC
CTTTTCAGAATAGAACTATTGGGGTGAGGATAAGGGGTGGGGGAGAAAAAATCACTGTTTGTTTTTAAAAAGCAAATCTTTCTGTAAACAGAATAAAAGT
TCCTCTCCCTTCCCTTCCCTCACCCCTGACATGTACCCCCTTTCCCTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGTAACATTTATAGAAGAAA
TGGAATGAATCTCCAAGGCTTTTAGGACTGTCTGAAAATTTGAGGCTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGACCTGAAATTGTATAGTG
TTGATTTGTGCTGAGATCAAGAGGCAGGTTAGAAGAACCTGACATCCACTGTTTGCCTTGGATAGTATGGCTTGTTTTTGGAAAGAAATTCTGAAGAGAG
TGGAGGAGAGGAGAAATGTCCTCATATTTGAGGACCATGAAACATTGTAGGTATATATGGGGCTTTAGCAAGTTTGAGCATAGGCTCTTTTTGCTGCCTG
TGAGCAGTCCCTCTGGAAAGAAACATGTGAGTAAGTGAGAGAGAGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGCGCACACATGCTTCTGTATTTCACT
CTTTCTCCCTATTAGGGAGTTATGCAAAATTTGTCCCCGATTTTACCTTTGTCTTTCTGTGTACTTTTCAAAGAGTCCTAAGGAGTTAAATCTTCCAGGT
ATTTTCCACTTAGTATTGCAGCCAAAGAATATTTAAATAAACGTCTTTGCTGCGCTTGCATCCATGCCCAGCCAATATACAACTGTAAAGCAAATATAGA
AAGTCGGCTGTTGATACGATTGTCTGTTATCGAACACATTCAGTGATAAAGCTGGGTTACTGCTGCTTTTGGTGCTCTCACCTTATCTGGAAGATCTGCA
AACATTACCTAAATAGGCTGGCAAGATAAACACTTTCTGGAACCCGAGACTTGGCCATAAAGATAATGCTGCATTTTTCTGTCAGAATCACATATGATGT
GTGTTCTGTAGAGGTTATTTCTGCATGGAAACTCAACTTCTTGGATTAGCCGTCCCAGTGAAAATCCTCATTGTTGGAGTGTAAACCAAATACGAAGCCC
TCTTGCAAAGTAGCCTCTTTCATCCCATACTCAAAATACCCAGTTTAGCAAGCAACTGAGATTTAAGTCTCTCTGGCCCTAAGAGGTTTTTCCTCTTTGC
TCCCTCCAATCTTGAGATTGGGTTTTGCTTTAGAGTGCAAGTATCATAATTCCGTATGATAGATGGGGCCTGGACACCCATCTCAACAGGGTCACTTGGT
AATTAACAATAGCCATATAAATGCGGATACAGGTTACTACCCTCACCCTTTACCTTCCTCAGGTAACAGTCGTAGATACCAGCTTTTTTTTTTTTTTTTT
TAAATTGGCTTTGGCCAGTAGCTAAAGTGCAAGACTGAATTAATGAGAAGATATATTAAATGTAGTCATAGGGGACTGAGGAGCAAGGGTGGCCTTGAAG
AGGCCAAAGGAATGTCCATTTGCTGAGTTTCCCTTCCTTATGTCTCCAGTCTGGTGCCAGGTAGTGGAGTAAAAAAGGAGACAGTTTATTTTTTTATTCT
ATGTGCACACTTACAGTATACATATATATTTATATCACAATTTACGAAACCAAAAAGTTGAGTTTCCAATGGAACCCTTGTTTTTTAATAATCGACTTTT
TAAATGTGATCAGGACTATAATATTGTACAGTTATTATAGGGCTTTTGGGGAAGGGGAGGATAGCGAGAAGATGCTCTGGGGGTTTTGTTTTTGCTTTTC
CTTCAGGGTTTTATTTTTGACTGTTTTGTTTTCTTGTTGGCCATTTCTGTATTGCTGGCATCTGTGCTAAGCTTTACAGTGGCAAAAATAATGACATGTA
GCAAAGATTTTCAAACAAAATATTTTTTCCTTTTGTAAAATTTCTTGTGTTGTGTGATCTTGATTGCGGCTTTATCATTCCTTTCCAGTTCATAAACAAC
AGGCACCCACAACCAGAGGAATCTATAGTTTAAGCTCCAGACATACAAACATAAGGCACATTGTGTCTTTAATTTCAGGAATCAGAAATCATAGGGTTCT
GATCACATTGCACGCCTCCCCCCTCACTTGTCCTCCTGATCCTGACACATTCTGAGTAACATCAGCAGGAATGCTCTGACCATGAGGTGGGGGTTTTGGG
GTGGGCGTTGCCTGGGTTCTTGGGAGAGAGGGGAAGAGTCGGGACTTGAAAACCACTAGGGCACATCTGGATGCCTTCCCCCAGTATGTCCTTTTCTGGA
TTAAAATGAGTGAAATTTAAACTG
  • refseq_ARNT.F1 (forward primer)
  • refseq_ARNT.R1 (reverse primer)
  • Single exon skipping

Frame 0

ILDSAVAEAAVRRRFWGVAFLFPSLPVRWRRLL
PLGGGVARRRWHLRPWRRLLPTPK*HQMYHHWVQ
PLPLETLDLEFKVEEPLSRGLLSGDQGWILMMM
EKGTVNF*GVMMIRCLTIRSGLPGRMMSRALRI
KRDLPGKITVKLNGGDGTR*QPTSQNCQIWYPPV
VPWLENQTS*PSYAWQFLT*SPCGELATHPLMA
PISRLSSLIRN*NI*SWRQQMAFCLLSHVRQAG
WCMCLTP*LLF*TSHSLNGLAAHSMIRCTQMMWI
NFVSSFPLQKMP*QGVSWI*RLEQ*KRKVSSLP
*ECVWAQGDRLFAE*GVAVALWTQFL*IG*AL*
GTDAGMDLAL*RMGNLTSWWSTAQATSRPGPQQV
FPSQMMTQRLAREASFA*WPLADCR*LVLPTVQ
T*VMFVNQQSSSPDTTLRVSSLLWITAVWLLLA
TSHRNS*ERIL*NSVILKTSSF*ETASNR**N*K
AKCCLSCSGSGLRTKNGSG*EPAPLLSRTLTQM
KLSTSSVPTPM*RTLAKNHGLHSPTQSRGHN*V
PQLIYPWRWAQDSWHPGSSNSKQNWTWYQEEMDW
PATIIPRWFSL*QPQDQNTASPLRSQMVYLPRI
EIQDFQKSITTSMRIRVKASPPALSLPPNSYSP
RATHSLLPPGRQRISGIVA*PLL*PLSSHQLLQD
RCWPRFPATPTPPKEQPQLGPLLPAQAFLPSRW
LPRLLLRLVLPSLVWAAFRLHPPSAPCPSLVPQ
LHRLVLLPTLVSPIVDLTLLLRLDRLQDNSRHGQ
QRVWVSGHSGRASSLIIVQVLVSNMFNNRQHSN
LASLRSSRRCCPCWEIRATATTMKNSLI*LCFP
PFQNRTIGVRIRGGGEKITVCF*KANLSVNRIKV
PLPSLPSPLTCTPFPFWLFPCSVASLR*HL*KK
WNESPRLLGLSENLRLGEVKTPFLMSPDLKLYS
VDLC*DQEAG*KNLTSTVCLG*YGLFLERNSEES
GGEEKCPHI*GP*NIVGIYGALASLSIGSFCCL
*AVPLERNM*VSERECVCMCVCVCVRTHASVFH
SFSLLGSYAKFVPDFTFVFLCTFQRVLRS*IFQV
FST*YCSQRIFK*TSLLRLHPCPANIQL*SKYR
KSAVDTIVCYRTHSVIKLGYCCFWCSHLIWKIC
KHYLNRLAR*TLSGTRDLAIKIMLHFSVRITYDV
CSVEVISAWKLNFLD*PSQ*KSSLLECKPNTKP
SCKVASFIPYSKYPV*QATEI*VSLALRGFSSL
LPPILRLGFALECKYHNSV**MGPGHPSQQGHLV
INNSHINADTGYYPHPLPSSGNSRRYQLFFFFF
*IGFGQ*LKCKTELMRRYIKCSHRGLRSKGGLE
EAKGMSIC*VSLPYVSSLVPGSGVKKETVYFFIL
CAHLQYTYIFISQFTKPKS*VSNGTLVF**STF
*M*SGL*YCTVIIGLLGKGRIARRCSGGFVFAF
PSGFYF*LFCFLVGHFCIAGICAKLYSGKNNDM*
QRFSNKIFFPFVKFLVLCDLDCGFIIPFQFINN
RHPQPEESIV*APDIQT*GTLCL*FQESEIIGF
*SHCTPPPSLVLLILTHSE*HQQECSDHEVGVLG
WALPGFLGERGRVGT*KPLGHIWMPSPSMSFSG
LK*VKFKL

Frame 1

SWIPR*RRRRSGAASGEWPFFSPPSRFGGGGSS
HWGGGWRGGGGICGHGGDYCQPRNDIRCTITGS
SHCLWKLWTWNSRWRSHCPEGY*AATRAGF***W
RREQ*IFEV***SDV*R*GAVCQVG**AELCG*
RETCQGKSQ*N*TAATEQDDSLHHRTVRYGTHL
*CPGSKTRQANHLTHGSFSHEVLAGNWQHIH*WL
L*AVFPH*SGTETFDLGGSRWLSVYCLM*DRQG
GVCV*LRDSCFEPATV*MVWQHTL*SGAPR*CG
*TS*AAFHFRKCPDRAYPGSKDWNSEKGRSAVFH
ENVYGLKEIVYLPNEVWQ*LCGPSFCE*AELCE
EQMQEWTWLCKGWGTSLRGGPLHRLHQGLAPSR
CFPPR**PRGWPGKQVLPSGHWQIAGN*FSQLYR
HE*CLSTNRVHLPTQH*GYLHFCGSPLCGYCWL
PATGTLRKEYCRILSS*RPAASKRQLPTGSEIK
RPSAVCHVPVPV*EPRMALDENQLLYFPEPLLR*
N*VHHLYQHQCEEL*PRTTAYTLQHNPEATTRS
HS*FTPGDGLRTAGTQAAATANRIGHGTRKRWT
GQLQSFPGGSACDNHRTRTQQAP*EVRWFICPG*
RSKIFRNLSQHQCGSE*RHLLQHCPCHPTAILP
GQHIPSYPPAGREFQE*WPSPSCNHCPAISFCR
TDVGPDFPPLQPHPRSNPNLDPYYPLRLFCPAGG
YPGYC*DSYFPVWCGQLSDSILLQLHVPPWCPN
CIAWCCCLP*SHQSWI*LCS*DWTDCRTIPDTD
SRGCGCLATVAGPAASSSFKF**ATCSTTASTAT
WPA*GLPGDAVHAGRSEQQLQQ*RIP*SNYVSP
LFRIELLG*G*GVGEKKSLFVFKKQIFL*TE*K
FLSLPFPHP*HVPPFPSGCSPALLPL*GNIYRRN
GMNLQGF*DCLKI*GWVKLKHLSLCLLT*NCIV
LICAEIKRQVRRT*HPLFALDSMACFWKEILKR
VEERRNVLIFEDHETL*VYMGL*QV*A*ALFAAC
EQSLWKETCE*VRESVCVCVCVCVCAHMLLYFT
LSPY*GVMQNLSPILPLSFCVLFKES*GVKSSR
YFPLSIAAKEYLNKRLCCACIHAQPIYNCKANIE
SRLLIRLSVIEHIQ**SWVTAAFGALTLSGRSA
NIT*IGWQDKHFLEPETWP*R*CCIFLSESHMM
CVL*RLFLHGNSTSWISRPSENPHCWSVNQIRSP
LAK*PLSSHTQNTQFSKQLRFKSLWP*EVFPLC
SLQS*DWVLL*SASIIIPYDRWGLDTHLNRVTW
*LTIAI*MRIQVTTLTLYLPQVTVVDTSFFFFFF
KLALASS*SARLN**EDILNVVIGD*GARVALK
RPKECPFAEFPFLMSPVWCQVVE*KRRQFIFLF
YVHTYSIHIYLYHNLRNQKVEFPMEPLFFNNRLF
KCDQDYNIVQLL*GFWGRGG*REDALGVLFLLF
LQGFIFDCFVFLLAISVLLASVLSFTVAKIMTC
SKDFQTKYFFLL*NFLCCVILIAALSFLSSS*TT
GTHNQRNL*FKLQTYKHKAHCVFNFRNQKS*GS
DHIARLPPHLSS*S*HILSNISRNALTMRWGFW
GGRCLGSWERGEESGLENH*GTSGCLPPVCPFLD
*NE*NLN

Frame 2

LGFRGSGGGGQAPLLGSGLSFPLPPGSVAAAPP
TGGGGGAAAVASAAMAATTANPEMTSDVPSLGP
AIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDD
GEGNSKFLRCDDDQMSNDKERFARSDDEQSSADK
ERLARENHSEIERRRRNKMTAYITELSDMVPTC
SALARKPDKLTILRMAVSHMKSLRGTGNTSTDG
SYKPSFLTDQELKHLILEAADGFLFIVSCETGRV
VYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVD
KLREQLSTSENALTGRILDLKTGTVKKEGQQSS
MRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVR
NRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAG
VSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCT
DMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGY
QPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLK
GQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSD
EIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGP
TANLPLEMGSGQLAPRQQQQQTELDMVPGRDGL
ASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQD
RDPRFSEIYHNINADQSKGISSSTVPATQQLFSQ
GNTFPPTPRPAENFRNSGLAPPVTIVQPSASAG
QMLAQISRHSNPTQGATPTWTPTTRSGFSAQQV
ATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPT
ASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRT
AEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQ
PGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPP
FSE*NYWGEDKGWGRKNHCLFLKSKSFCKQNKS
SSPFPSLTPDMYPLSLLAVPLLCCLSKVTFIEE
ME*ISKAFRTV*KFEAG*S*NTFPYVS*PEIV*C
*FVLRSRGRLEEPDIHCLPWIVWLVFGKKF*RE
WRRGEMSSYLRTMKHCRYIWGFSKFEHRLFLLP
VSSPSGKKHVSK*ERVCVYVCVCVCAHTCFCISL
FLPIRELCKICPRFYLCLSVYFSKSPKELNLPG
IFHLVLQPKNI*INVFAALASMPSQYTTVKQI*
KVGC*YDCLLSNTFSDKAGLLLLLVLSPYLEDLQ
TLPK*AGKINTFWNPRLGHKDNAAFFCQNHI*C
VFCRGYFCMETQLLGLAVPVKILIVGV*TKYEA
LLQSSLFHPILKIPSLASN*DLSLSGPKRFFLFA
PSNLEIGFCFRVQVS*FRMIDGAWTPISTGSLG
N*Q*PYKCGYRLLPSPFTFLR*QS*IPAFFFFF
LNWLWPVAKVQD*INEKIY*M*S*GTEEQGWP*R
GQRNVHLLSFPSLCLQSGAR*WSKKGDSLFFYS
MCTLTVYIYIYITIYETKKLSFQWNPCFLIIDF
LNVIRTIILYSYYRAFGEGEDSEKMLWGFCFCFS
FRVLFLTVLFSCWPFLYCWHLC*ALQWQK**HV
AKIFKQNIFSFCKISCVV*S*LRLYHSFPVHKQ
QAPTTRGIYSLSSRHTNIRHIVSLISGIRNHRVL
ITLHASPLTCPPDPDTF*VTSAGML*P*GGGFG
VGVAWVLGREGKSRDLKTTRAHLDAFPQYVLFW
IKMSEI*T

Sequence NM_178426

ATCTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCC
CACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCA
GCCATTGCCTCTGGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATG
GAGAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGGTCGGATGATGAGCAGAGCTCTGCGGATAA
AGAGAGACTTGCCAGGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCCTACATCACAGAACTGTCAGATATGGTACCCACCTGT
AGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCTCACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCT
CCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTGATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGT
GGTGTATGTGTCTGACTCCGTGACTCCTGTTTTGAACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGAT
AAACTTCGTGAGCAGCTTTCCACTTCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCA
TGAGAATGTGTATGGGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAG
GAACAGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCAGCAGGT
GTTTCCCTCCCAGATGATGACCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGAGATCAGAGCAACAGCTACAACAATGAAGAATTCCCTGAT
CTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAGGGGTGGGGGAGAAAAAATCACTGTTTGTTTTTAAAAAGCAAATCTTTCT
GTAAACAGAATAAAAGTTCCTCTCCCTTCCCTTCCCTCACCCCTGACATGTACCCCCTTTCCCTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGT
AACATTTATAGAAGAAATGGAATGAATCTCCAAGGCTTTTAGGACTGTCTGAAAATTTGAGGCTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGA
CCTGAAATTGTATAGTGTTGATTTGTGCTGAGATCAAGAGGCAGGTTAGAAGAACCTGACATCCACTGTTTGCCTTGGATAGTATGGCTTGTTTTTGGAA
AGAAATTCTGAAGAGAGTGGAGGAGAGGAGAAATGTCCTCATATTTGAGGACCATGAAACATTGTAGGTATATATGGGGCTTTAGCAAGTTTGAGCATAG
GCTCTTTTTGCTGCCTGTGAGCAGTCCCTCTGGAAAGAAACATGTGAGTAAGTGAGAGAGAGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGCGCACACA
TGCTTCTGTATTTCACTCTTTCTCCCTATTAGGGAGTTATGCAAAATTTGTCCCCGATTTTACCTTTGTCTTTCTGTGTACTTTTCAAAGAGTCCTAAGG
AGTTAAATCTTCCAGGTATTTTCCACTTAGTATTGCAGCCAAAGAATATTTAAATAAACGTCTTTGCTGCGCTTGCATCCATGCCCAGCCAATATACAAC
TGTAAAGCAAATATAGAAAGTCGGCTGTTGATACGATTGTCTGTTATCGAACACATTCAGTGATAAAGCTGGGTTACTGCTGCTTTTGGTGCTCTCACCT
TATCTGGAAGATCTGCAAACATTACCTAAATAGGCTGGCAAGATAAACACTTTCTGGAACCCGAGACTTGGCCATAAAGATAATGCTGCATTTTTCTGTC
AGAATCACATATGATGTGTGTTCTGTAGAGGTTATTTCTGCATGGAAACTCAACTTCTTGGATTAGCCGTCCCAGTGAAAATCCTCATTGTTGGAGTGTA
AACCAAATACGAAGCCCTCTTGCAAAGTAGCCTCTTTCATCCCATACTCAAAATACCCAGTTTAGCAAGCAACTGAGATTTAAGTCTCTCTGGCCCTAAG
AGGTTTTTCCTCTTTGCTCCCTCCAATCTTGAGATTGGGTTTTGCTTTAGAGTGCAAGTATCATAATTCCGTATGATAGATGGGGCCTGGACACCCATCT
CAACAGGGTCACTTGGTAATTAACAATAGCCATATAAATGCGGATACAGGTTACTACCCTCACCCTTTACCTTCCTCAGGTAACAGTCGTAGATACCAGC
TTTTTTTTTTTTTTTTTTAAATTGGCTTTGGCCAGTAGCTAAAGTGCAAGACTGAATTAATGAGAAGATATATTAAATGTAGTCATAGGGGACTGAGGAG
CAAGGGTGGCCTTGAAGAGGCCAAAGGAATGTCCATTTGCTGAGTTTCCCTTCCTTATGTCTCCAGTCTGGTGCCAGGTAGTGGAGTAAAAAAGGAGACA
GTTTATTTTTTTATTCTATGTGCACACTTACAGTATACATATATATTTATATCACAATTTACGAAACCAAAAAGTTGAGTTTCCAATGGAACCCTTGTTT
TTTAATAATCGACTTTTTAAATGTGATCAGGACTATAATATTGTACAGTTATTATAGGGCTTTTGGGGAAGGGGAGGATAGCGAGAAGATGCTCTGGGGG
TTTTGTTTTTGCTTTTCCTTCAGGGTTTTATTTTTGACTGTTTTGTTTTCTTGTTGGCCATTTCTGTATTGCTGGCATCTGTGCTAAGCTTTACAGTGGC
AAAAATAATGACATGTAGCAAAGATTTTCAAACAAAATATTTTTTCCTTTTGTAAAATTTCTTGTGTTGTGTGATCTTGATTGCGGCTTTATCATTCCTT
TCCAGTTCATAAACAACAGGCACCCACAACCAGAGGAATCTATAGTTTAAGCTCCAGACATACAAACATAAGGCACATTGTGTCTTTAATTTCAGGAATC
AGAAATCATAGGGTTCTGATCACATTGCACGCCTCCCCCCTCACTTGTCCTCCTGATCCTGACACATTCTGAGTAACATCAGCAGGAATGCTCTGACCAT
GAGGTGGGGGTTTTGGGGTGGGCGTTGCCTGGGTTCTTGGGAGAGAGGGGAAGAGTCGGGACTTGAAAACCACTAGGGCACATCTGGATGCCTTCCCCCA
GTATGTCCTTTTCTGGATTAAAATGAGTGAAATTTAAACTG
  • refseq_ARNT.F1 (forward primer)
  • refseq_ARNT.R1 (reverse primer)
  • Single exon skipping

Frame 0

ILDSAVAEAAVRRRFWGVAFLFPSLPVRWRRLL
PLGGGVARRRWHLRPWRRLLPTPK*HQMYHHWVQ
PLPLETLDLEFKVEEPLSRGLLSGDQGWILMMM
EKGTVNF*GVMMIRCLTIRSGLPGRMMSRALRI
KRDLPGKITVKLNGGDGTR*QPTSQNCQIWYPPV
VPWLENQTS*PSYAWQFLT*SPCGELATHPLMA
PISRLSSLIRN*NI*SWRQQMAFCLLSHVRQAG
WCMCLTP*LLF*TSHSLNGLAAHSMIRCTQMMWI
NFVSSFPLQKMP*QGVSWI*RLEQ*KRKVSSLP
*ECVWAQGDRLFAE*GVAVALWTQFL*IG*AL*
GTDAGMDLAL*RMGNLTSWWSTAQATSRPGPQQV
FPSQMMTQPEVFQEMLSMLGDQSNSYNNEEFPD
LTMFPPFSE*NYWGEDKGWGRKNHCLFLKSKSF
CKQNKSSSPFPSLTPDMYPLSLLAVPLLCCLSKV
TFIEEME*ISKAFRTV*KFEAG*S*NTFPYVS*
PEIV*C*FVLRSRGRLEEPDIHCLPWIVWLVFG
KKF*REWRRGEMSSYLRTMKHCRYIWGFSKFEHR
LFLLPVSSPSGKKHVSK*ERVCVYVCVCVCAHT
CFCISLFLPIRELCKICPRFYLCLSVYFSKSPK
ELNLPGIFHLVLQPKNI*INVFAALASMPSQYTT
VKQI*KVGC*YDCLLSNTFSDKAGLLLLLVLSP
YLEDLQTLPK*AGKINTFWNPRLGHKDNAAFFC
QNHI*CVFCRGYFCMETQLLGLAVPVKILIVGV*
TKYEALLQSSLFHPILKIPSLASN*DLSLSGPK
RFFLFAPSNLEIGFCFRVQVS*FRMIDGAWTPI
STGSLGN*Q*PYKCGYRLLPSPFTFLR*QS*IPA
FFFFFLNWLWPVAKVQD*INEKIY*M*S*GTEE
QGWP*RGQRNVHLLSFPSLCLQSGAR*WSKKGD
SLFFYSMCTLTVYIYIYITIYETKKLSFQWNPCF
LIIDFLNVIRTIILYSYYRAFGEGEDSEKMLWG
FCFCFSFRVLFLTVLFSCWPFLYCWHLC*ALQW
QK**HVAKIFKQNIFSFCKISCVV*S*LRLYHSF
PVHKQQAPTTRGIYSLSSRHTNIRHIVSLISGI
RNHRVLITLHASPLTCPPDPDTF*VTSAGML*P
*GGGFGVGVAWVLGREGKSRDLKTTRAHLDAFPQ
YVLFWIKMSEI*T

Frame 1

SWIPR*RRRRSGAASGEWPFFSPPSRFGGGGSS
HWGGGWRGGGGICGHGGDYCQPRNDIRCTITGS
SHCLWKLWTWNSRWRSHCPEGY*AATRAGF***W
RREQ*IFEV***SDV*R*GAVCQVG**AELCG*
RETCQGKSQ*N*TAATEQDDSLHHRTVRYGTHL
*CPGSKTRQANHLTHGSFSHEVLAGNWQHIH*WL
L*AVFPH*SGTETFDLGGSRWLSVYCLM*DRQG
GVCV*LRDSCFEPATV*MVWQHTL*SGAPR*CG
*TS*AAFHFRKCPDRAYPGSKDWNSEKGRSAVFH
ENVYGLKEIVYLPNEVWQ*LCGPSFCE*AELCE
EQMQEWTWLCKGWGTSLRGGPLHRLHQGLAPSR
CFPPR**PSLRSSRRCCPCWEIRATATTMKNSLI
*LCFPPFQNRTIGVRIRGGGEKITVCF*KANLS
VNRIKVPLPSLPSPLTCTPFPFWLFPCSVASLR
*HL*KKWNESPRLLGLSENLRLGEVKTPFLMSPD
LKLYSVDLC*DQEAG*KNLTSTVCLG*YGLFLE
RNSEESGGEEKCPHI*GP*NIVGIYGALASLSI
GSFCCL*AVPLERNM*VSERECVCMCVCVCVRTH
ASVFHSFSLLGSYAKFVPDFTFVFLCTFQRVLR
S*IFQVFST*YCSQRIFK*TSLLRLHPCPANIQ
L*SKYRKSAVDTIVCYRTHSVIKLGYCCFWCSHL
IWKICKHYLNRLAR*TLSGTRDLAIKIMLHFSV
RITYDVCSVEVISAWKLNFLD*PSQ*KSSLLEC
KPNTKPSCKVASFIPYSKYPV*QATEI*VSLALR
GFSSLLPPILRLGFALECKYHNSV**MGPGHPS
QQGHLVINNSHINADTGYYPHPLPSSGNSRRYQ
LFFFFF*IGFGQ*LKCKTELMRRYIKCSHRGLRS
KGGLEEAKGMSIC*VSLPYVSSLVPGSGVKKET
VYFFILCAHLQYTYIFISQFTKPKS*VSNGTLV
F**STF*M*SGL*YCTVIIGLLGKGRIARRCSGG
FVFAFPSGFYF*LFCFLVGHFCIAGICAKLYSG
KNNDM*QRFSNKIFFPFVKFLVLCDLDCGFIIP
FQFINNRHPQPEESIV*APDIQT*GTLCL*FQES
EIIGF*SHCTPPPSLVLLILTHSE*HQQECSDH
EVGVLGWALPGFLGERGRVGT*KPLGHIWMPSP
SMSFSGLK*VKFKL

Frame 2

LGFRGSGGGGQAPLLGSGLSFPLPPGSVAAAPP
TGGGGGAAAVASAAMAATTANPEMTSDVPSLGP
AIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDD
GEGNSKFLRCDDDQMSNDKERFARSDDEQSSADK
ERLARENHSEIERRRRNKMTAYITELSDMVPTC
SALARKPDKLTILRMAVSHMKSLRGTGNTSTDG
SYKPSFLTDQELKHLILEAADGFLFIVSCETGRV
VYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVD
KLREQLSTSENALTGRILDLKTGTVKKEGQQSS
MRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVR
NRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAG
VSLPDDDPA*GLPGDAVHAGRSEQQLQQ*RIP*
SNYVSPLFRIELLG*G*GVGEKKSLFVFKKQIFL
*TE*KFLSLPFPHP*HVPPFPSGCSPALLPL*G
NIYRRNGMNLQGF*DCLKI*GWVKLKHLSLCLL
T*NCIVLICAEIKRQVRRT*HPLFALDSMACFWK
EILKRVEERRNVLIFEDHETL*VYMGL*QV*A*
ALFAACEQSLWKETCE*VRESVCVCVCVCVCAH
MLLYFTLSPY*GVMQNLSPILPLSFCVLFKES*G
VKSSRYFPLSIAAKEYLNKRLCCACIHAQPIYN
CKANIESRLLIRLSVIEHIQ**SWVTAAFGALT
LSGRSANIT*IGWQDKHFLEPETWP*R*CCIFLS
ESHMMCVL*RLFLHGNSTSWISRPSENPHCWSV
NQIRSPLAK*PLSSHTQNTQFSKQLRFKSLWP*
EVFPLCSLQS*DWVLL*SASIIIPYDRWGLDTHL
NRVTW*LTIAI*MRIQVTTLTLYLPQVTVVDTS
FFFFFFKLALASS*SARLN**EDILNVVIGD*G
ARVALKRPKECPFAEFPFLMSPVWCQVVE*KRRQ
FIFLFYVHTYSIHIYLYHNLRNQKVEFPMEPLF
FNNRLFKCDQDYNIVQLL*GFWGRGG*REDALG
VLFLLFLQGFIFDCFVFLLAISVLLASVLSFTVA
KIMTCSKDFQTKYFFLL*NFLCCVILIAALSFL
SSS*TTGTHNQRNL*FKLQTYKHKAHCVFNFRN
QKS*GSDHIARLPPHLSS*S*HILSNISRNALTM
RWGFWGGRCLGSWERGEESGLENH*GTSGCLPP
VCPFLD*NE*NLN

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