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Sequences

Sequence NM_001030272

GGAAAGTAGGTTAGTGGTGCGACATTTAGGGAAGGCAGAAAGTAGGTCAGGGACGGAGGTGCCTGTTTACCCGCGCCGGACTCACCGCCGCCGCCGCCGC
GGGATCCGAGTGCGGGCGCGGGCGCGGGCGCTCCCGGCGAGCCACGGTGGTGCTGGCTAGAGTGTATACGTTTGGACCCAAGCTTAACTTTTCCAATGTG
GAATCCTGGGCCTTCATTGGTTTTTGGAAGAAGCTGACCGCCTGAAAAGAAATTATAAAACATGAAAATCGCTTTGAGGTGACCAAGTCCAGAGGCCCCT
AACTCCTCCCAAGCTGGATCTGGGGTGTAAGAACTGTGACTTCAGATCATCCAATGGCAGACCAGAGAATGGACATTTCTTCAACCATCAGTGATTTCAT
GTCCCCGGGCCCCACCGACCTGCTTTCCAGCTCTCTTGGTACCAGTGGTGTGGATTGCAACCGCAAACGGAAAGGCAGCTCCACTGACTACCAAGAAAGC
ATGGACACAGACAAAGATGACCCTCATGGAAGGTTAGAATATACAGAACACCAAGGAAGGATAAAAAATGCAAGGGAAGCTCACAGTCAGATTGAAAAGC
GGCGTCGGGATAAAATGAACAGTTTTATAGATGAATTGGCTTCTTTGGTACCAACATGCAACGCAATGTCCAGGAAATTAGATAAACTTACTGTGCTAAG
GATGGCTGTTCAGCACATGAAAACATTAAGAGGTGCCACCAATCCATACACAGAAGCAAACTACAAACCAACTTTTCTATCAGACGATGAATTGAAACAC
CTCATTCTCAGGGCAGCAGATGGATTTTTGTTTGTCGTAGGATGTGACCGAGGGAAGATACTCTTTGTCTCAGAGTCTGTCTTCAAGATCCTCAACTACA
GCCAGAATGATCTGATTGGTCAGAGTTTGTTTGACTACCTGCATCCTAAAGATATTGCCAAAGTCAAGGAGCAGCTCTCCTCCTCTGACACCGCACCCCG
GGAGCGGCTCATAGATGCAAAAACTGGACTTCCAGTTAAAACAGATATAACCCCTGGGCCATCTCGATTATGTTCTGGAGCACGACGTTCTTTCTTCTGT
AGGATGAAGTGTAACAGGCCTTCAGTAAAGGTTGAAGACAAGGACTTCCCCTCTACCTGCTCAAAGAAAAAAGATCGAAAAAGCTTCTGCACAATCCACA
GCACAGGCTATTTGAAAAGCTGGCCACCCACAAAGATGGGGCTGGATGAAGACAACGAACCAGACAATGAGGGGTGTAACCTCAGCTGCCTCGTCGCAAT
TGGACGACTGCATTCTCATGTAGTTCCACAACCAGTGAACGGGGAAATCAGGGTGAAATCTATGGAATATGTTTCTCGGCACGCGATAGATGGAAAGTTT
GTTTTTGTAGACCAGAGGGCAACAGCTATTTTGGCATATTTACCACAAGAACTTCTAGGCACATCGTGTTATGAATATTTTCACCAAGATGACATAGGAC
ATCTTGCAGAATGTCATAGGCAAGTTTTACAGACGAGAGAAAAAATTACAACTAATTGCTATAAATTTAAAATCAAAGATGGTTCTTTTATCACACTACG
GAGTCGATGGTTCAGTTTCATGAACCCTTGGACCAAGGAAGTAGAATATATTGTCTCAACTAACACTGTTGTTTTAGCCAACGTCCTGGAAGGCGGGGAC
CCAACCTTCCCACAGCTCACAGCATCCCCCCACAGCATGGACAGCATGCTGCCCTCTGGAGAAGGTGGCCCAAAGAGGACCCACCCCACTGTTCCAGGGA
TTCCAGGGGGAACCCGGGCTGGGGCAGGAAAAATAGGCCGAATGATTGCTGAGGAAATCATGGAAATCCACAGGATAAGAGGGTCATCGCCTTCTAGCTG
TGGCTCCAGCCCATTGAACATCACGAGTACGCCTCCCCCTGATGCCTCTTCTCCAGGAGGCAAGAAGATTTTAAATGGAGGGACTCCAGACATTCCTTCC
AGTGGCCTACTATCAGGCCAGGCTCAGGAGAACCCAGGTTATCCATATTCTGATAGTTCTTCTATTCTTGGTGAGAACCCCCACATAGGTATAGACATGA
TTGACAACGACCAAGGATCAAGTAGTCCCAGTAATGATGAGGCAGCAATGGCTGTCATCATGAGCCTCTTGGAAGCAGATGCTGGACTGGGTGGCCCTGT
TGACTTTAGTGACTTGCCATGGCCGCTGTAAACACTACATGTTGCTTTGGCAACAGCTATAGTATCAAAGTGCATTACTGGTGGAGTTTTACAGTCTGTG
AAGCTTACTGGATAAGGAGAGAATAGCTTTTATGTACTGACTTCATAAAAGCCATCTCAGAGCCATTGATACAAGTCAATCTTACTATATGTAACTTCAG
ACAAAGTGGAACTAAGCCTGCTCCAGTGTTTCCTCATCATTGATTATTGGGCTAGCTGTGGATAGCTTGCATTAATTGTATATTTTGGATTCTGTTTGTG
TTGAATTTTTTAATCATTGTGCACAGAAGCATCATTGGTAGCTTTTATATGCAAATGGTCATTTCAGATGTATGGTGTTTTTACACTACAAAGAAGTCCC
CCATGTGGATATTTCTTATACTAATTGTATCATAAAGCCGTTTATTCTTCCTTGTAAGAATCCTTTACTATAAATATGGGTTAAAGTATAATGTACTAGA
CAGTTAAATATTTTTAATAAATGTTTCCCTTGTTCTATAAA
  • refseq_ARNTL.F4 (forward primer)
  • refseq_ARNTL.R4 (reverse primer)
  • Single exon skipping

Frame 0

GK*VSGATFREGRK*VRDGGACLPAPDSPPPPP
RDPSAGAGAGAPGEPRWCWLECIRLDPSLTFPMW
NPGPSLVFGRS*PPEKKL*NMKIALR*PSPEAP
NSSQAGSGV*EL*LQIIQWQTREWTFLQPSVIS
CPRAPPTCFPALLVPVVWIATANGKAAPLTTKKA
WTQTKMTLMEG*NIQNTKEG*KMQGKLTVRLKS
GVGIK*TVL*MNWLLWYQHATQCPGN*INLLC*
GWLFST*KH*EVPPIHTQKQTTNQLFYQTMN*NT
SFSGQQMDFCLS*DVTEGRYSLSQSLSSRSSTT
ARMI*LVRVCLTTCILKILPKSRSSSPPLTPHP
GSGS*MQKLDFQLKQI*PLGHLDYVLEHDVLSSV
G*SVTGLQ*RLKTRTSPLPAQRKKIEKASAQST
AQAI*KAGHPQRWGWMKTTNQTMRGVTSAASSQ
LDDCILM*FHNQ*TGKSG*NLWNMFLGTR*MESL
FL*TRGQQLFWHIYHKNF*AHRVMNIFTKMT*D
ILQNVIGKFYRREKKLQLIAINLKSKMVLLSHY
GVDGSVS*TLGPRK*NILSQLTLLF*PTSWKAGT
QPSHSSQHPPTAWTACCPLEKVAQRGPTPLFQG
FQGEPGLGQEK*AE*LLRKSWKSTG*EGHRLLA
VAPAH*TSRVRLPLMPLLQEARRF*MEGLQTFLP
VAYYQARLRRTQVIHILIVLLFLVRTPT*V*T*
LTTTKDQVVPVMMRQQWLSS*ASWKQMLDWVAL
LTLVTCHGRCKHYMLLWQQL*YQSALLVEFYSL*
SLLDKERIAFMY*LHKSHLRAIDTSQSYYM*LQ
TKWN*ACSSVSSSLIIGLAVDSLH*LYILDSVC
VEFFNHCAQKHHW*LLYANGHFRCMVFLHYKEVP
HVDISYTNCIIKPFILPCKNPLL*IWVKV*CTR
QLNIFNKCFPCSI

Frame 1

ESRLVVRHLGKAESRSGTEVPVYPRRTHRRRRR
GIRVRARARALPASHGGAG*SVYVWTQA*LFQC
GILGLHWFLEEADRLKRNYKT*KSL*GDQVQRPL
TPPKLDLGCKNCDFRSSNGRPENGHFFNHQ*FH
VPGPHRPAFQLSWYQWCGLQPQTERQLH*LPRK
HGHRQR*PSWKVRIYRTPRKDKKCKGSSQSD*KA
ASG*NEQFYR*IGFFGTNMQRNVQEIR*TYCAK
DGCSAHENIKRCHQSIHRSKLQTNFSIRR*IET
PHSQGSRWIFVCRRM*PREDTLCLRVCLQDPQLQ
PE*SDWSEFV*LPAS*RYCQSQGAALLL*HRTP
GAAHRCKNWTSS*NRYNPWAISIMFWSTTFFLL
*DEV*QAFSKG*RQGLPLYLLKEKRSKKLLHNPQ
HRLFEKLATHKDGAG*RQRTRQ*GV*PQLPRRN
WTTAFSCSSTTSERGNQGEIYGICFSARDRWKV
CFCRPEGNSYFGIFTTRTSRHIVL*IFSPR*HRT
SCRMS*ASFTDERKNYN*LL*I*NQRWFFYHTT
ESMVQFHEPLDQGSRIYCLN*HCCFSQRPGRRG
PNLPTAHSIPPQHGQHAALWRRWPKEDPPHCSRD
SRGNPGWGRKNRPNDC*GNHGNPQDKRVIAF*L
WLQPIEHHEYASP*CLFSRRQEDFKWRDSRHSF
QWPTIRPGSGEPRLSIF**FFYSW*EPPHRYRHD
*QRPRIK*SQ***GSNGCHHEPLGSRCWTGWPC
*L**LAMAAVNTTCCFGNSYSIKVHYWWSFTVC
EAYWIRRE*LLCTDFIKAISEPLIQVNLTICNFR
QSGTKPAPVFPHH*LLG*LWIACINCIFWILFV
LNFLIIVHRSIIGSFYMQMVISDVWCFYTTKKS
PMWIFLILIVS*SRLFFLVRILYYKYGLKYNVLD
S*IFLINVSLVL*

Frame 2

KVG*WCDI*GRQKVGQGRRCLFTRAGLTAAAAA
GSECGRGRGRSRRATVVLARVYTFGPKLNFSNV
ESWAFIGFWKKLTA*KEIIKHENRFEVTKSRGP
*LLPSWIWGVRTVTSDHPMADQRMDISSTISDFM
SPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQES
MDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEK
RRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLR
MAVQHMKTLRGATNPYTEANYKPTFLSDDELKH
LILRAADGFLFVVGCDRGKILFVSESVFKILNY
SQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPR
ERLIDAKTGLPVKTDITPGPSRLCSGARRSFFC
RMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIH
STGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAI
GRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKF
VFVDQRATAILAYLPQELLGTSCYEYFHQDDIG
HLAECHRQVLQTREKITTNCYKFKIKDGSFITLR
SRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGD
PTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPG
IPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSC
GSSPLNITSTPPPDASSPGGKKILNGGTPDIPS
SGLLSGQAQENPGYPYSDSSSILGENPHIGIDM
IDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPV
DFSDLPWPL*TLHVALATAIVSKCITGGVLQSV
KLTG*GENSFYVLTS*KPSQSH*YKSILLYVTS
DKVELSLLQCFLIIDYWASCG*LALIVYFGFCLC
*IF*SLCTEASLVAFICKWSFQMYGVFTLQRSP
PCGYFLY*LYHKAVYSSL*ESFTINMG*SIMY*
TVKYF**MFPLFYK

Sequence NM_001178

GGAAAGTAGGTTAGTGGTGCGACATTTAGGGAAGGCAGAAAGTAGGTCAGGGACGGAGGTGCCTGTTTACCCGCGCCGGACTCACCGCCGCCGCCGCCGC
GGGATCCGAGTGCGGGCGCGGGCGCGGGCGCTCCCGGCGAGCCACGGTGGTGCTGGCTAGAGTGTATACGTTTGGACCCAAGCTTAACTTTTCCAATGTG
GAATCCTGGGCCTTCATTGGTTCCGATGTCATAGGAATCTACGCTAGAGGGCTTCCTGTGTGCCGGGCACTGTGGTTTTTGGAAGAAGCTGACCGCCTGA
AAAGAAATTATAAAACATGAAAATCGCTTTGAGGTGACCAAGTCCAGAGGCCCCTAACTCCTCCCAAGCTGGATCTGGGGTGTAAGAACTGTGACTTCAG
ATCATCCAATGGCAGACCAGAGAATGGACATTTCTTCAACCATCAGTGATTTCATGTCCCCGGGCCCCACCGACCTGCTTTCCAGCTCTCTTGGTACCAG
TGGTGTGGATTGCAACCGCAAACGGAAAGGCAGCTCCACTGACTACCAAGAAAGCATGGACACAGACAAAGATGACCCTCATGGAAGGTTAGAATATACA
GAACACCAAGGAAGGATAAAAAATGCAAGGGAAGCTCACAGTCAGATTGAAAAGCGGCGTCGGGATAAAATGAACAGTTTTATAGATGAATTGGCTTCTT
TGGTACCAACATGCAACGCAATGTCCAGGAAATTAGATAAACTTACTGTGCTAAGGATGGCTGTTCAGCACATGAAAACATTAAGAGGTGCCACCAATCC
ATACACAGAAGCAAACTACAAACCAACTTTTCTATCAGACGATGAATTGAAACACCTCATTCTCAGGGCAGCAGATGGATTTTTGTTTGTCGTAGGATGT
GACCGAGGGAAGATACTCTTTGTCTCAGAGTCTGTCTTCAAGATCCTCAACTACAGCCAGAATGATCTGATTGGTCAGAGTTTGTTTGACTACCTGCATC
CTAAAGATATTGCCAAAGTCAAGGAGCAGCTCTCCTCCTCTGACACCGCACCCCGGGAGCGGCTCATAGATGCAAAAACTGGACTTCCAGTTAAAACAGA
TATAACCCCTGGGCCATCTCGATTATGTTCTGGAGCACGACGTTCTTTCTTCTGTAGGATGAAGTGTAACAGGCCTTCAGTAAAGGTTGAAGACAAGGAC
TTCCCCTCTACCTGCTCAAAGAAAAAAGATCGAAAAAGCTTCTGCACAATCCACAGCACAGGCTATTTGAAAAGCTGGCCACCCACAAAGATGGGGCTGG
ATGAAGACAACGAACCAGACAATGAGGGGTGTAACCTCAGCTGCCTCGTCGCAATTGGACGACTGCATTCTCATGTAGTTCCACAACCAGTGAACGGGGA
AATCAGGGTGAAATCTATGGAATATGTTTCTCGGCACGCGATAGATGGAAAGTTTGTTTTTGTAGACCAGAGGGCAACAGCTATTTTGGCATATTTACCA
CAAGAACTTCTAGGCACATCGTGTTATGAATATTTTCACCAAGATGACATAGGACATCTTGCAGAATGTCATAGGCAAGTTTTACAGACGAGAGAAAAAA
TTACAACTAATTGCTATAAATTTAAAATCAAAGATGGTTCTTTTATCACACTACGGAGTCGATGGTTCAGTTTCATGAACCCTTGGACCAAGGAAGTAGA
ATATATTGTCTCAACTAACACTGTTGTTTTAGCCAACGTCCTGGAAGGCGGGGACCCAACCTTCCCACAGCTCACAGCATCCCCCCACAGCATGGACAGC
ATGCTGCCCTCTGGAGAAGGTGGCCCAAAGAGGACCCACCCCACTGTTCCAGGGATTCCAGGGGGAACCCGGGCTGGGGCAGGAAAAATAGGCCGAATGA
TTGCTGAGGAAATCATGGAAATCCACAGGATAAGAGGGTCATCGCCTTCTAGCTGTGGCTCCAGCCCATTGAACATCACGAGTACGCCTCCCCCTGATGC
CTCTTCTCCAGGAGGCAAGAAGATTTTAAATGGAGGGACTCCAGACATTCCTTCCAGTGGCCTACTATCAGGCCAGGCTCAGGAGAACCCAGGTTATCCA
TATTCTGATAGTTCTTCTATTCTTGGTGAGAACCCCCACATAGGTATAGACATGATTGACAACGACCAAGGATCAAGTAGTCCCAGTAATGATGAGGCAG
CAATGGCTGTCATCATGAGCCTCTTGGAAGCAGATGCTGGACTGGGTGGCCCTGTTGACTTTAGTGACTTGCCATGGCCGCTGTAAACACTACATGTTGC
TTTGGCAACAGCTATAGTATCAAAGTGCATTACTGGTGGAGTTTTACAGTCTGTGAAGCTTACTGGATAAGGAGAGAATAGCTTTTATGTACTGACTTCA
TAAAAGCCATCTCAGAGCCATTGATACAAGTCAATCTTACTATATGTAACTTCAGACAAAGTGGAACTAAGCCTGCTCCAGTGTTTCCTCATCATTGATT
ATTGGGCTAGCTGTGGATAGCTTGCATTAATTGTATATTTTGGATTCTGTTTGTGTTGAATTTTTTAATCATTGTGCACAGAAGCATCATTGGTAGCTTT
TATATGCAAATGGTCATTTCAGATGTATGGTGTTTTTACACTACAAAGAAGTCCCCCATGTGGATATTTCTTATACTAATTGTATCATAAAGCCGTTTAT
TCTTCCTTGTAAGAATCCTTTACTATAAATATGGGTTAAAGTATAATGTACTAGACAGTTAAATATTTTTAATAAATGTTTCCCTTGTTCTATAAA
  • refseq_ARNTL.F4 (forward primer)
  • refseq_ARNTL.R4 (reverse primer)
  • Single exon skipping

Frame 0

GK*VSGATFREGRK*VRDGGACLPAPDSPPPPP
RDPSAGAGAGAPGEPRWCWLECIRLDPSLTFPMW
NPGPSLVPMS*ESTLEGFLCAGHCGFWKKLTA*
KEIIKHENRFEVTKSRGP*LLPSWIWGVRTVTS
DHPMADQRMDISSTISDFMSPGPTDLLSSSLGTS
GVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYT
EHQGRIKNAREAHSQIEKRRRDKMNSFIDELAS
LVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNP
YTEANYKPTFLSDDELKHLILRAADGFLFVVGC
DRGKILFVSESVFKILNYSQNDLIGQSLFDYLH
PKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTD
ITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKD
FPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGL
DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGE
IRVKSMEYVSRHAIDGKFVFVDQRATAILAYLP
QELLGTSCYEYFHQDDIGHLAECHRQVLQTREK
ITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVE
YIVSTNTVVLANVLEGGDPTFPQLTASPHSMDS
MLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRM
IAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDA
SSPGGKKILNGGTPDIPSSGLLSGQAQENPGYP
YSDSSSILGENPHIGIDMIDNDQGSSSPSNDEA
AMAVIMSLLEADAGLGGPVDFSDLPWPL*TLHVA
LATAIVSKCITGGVLQSVKLTG*GENSFYVLTS
*KPSQSH*YKSILLYVTSDKVELSLLQCFLIID
YWASCG*LALIVYFGFCLC*IF*SLCTEASLVAF
ICKWSFQMYGVFTLQRSPPCGYFLY*LYHKAVY
SSL*ESFTINMG*SIMY*TVKYF**MFPLFYK

Frame 1

ESRLVVRHLGKAESRSGTEVPVYPRRTHRRRRR
GIRVRARARALPASHGGAG*SVYVWTQA*LFQC
GILGLHWFRCHRNLR*RASCVPGTVVFGRS*PPE
KKL*NMKIALR*PSPEAPNSSQAGSGV*EL*LQ
IIQWQTREWTFLQPSVISCPRAPPTCFPALLVP
VVWIATANGKAAPLTTKKAWTQTKMTLMEG*NIQ
NTKEG*KMQGKLTVRLKSGVGIK*TVL*MNWLL
WYQHATQCPGN*INLLC*GWLFST*KH*EVPPI
HTQKQTTNQLFYQTMN*NTSFSGQQMDFCLS*DV
TEGRYSLSQSLSSRSSTTARMI*LVRVCLTTCI
LKILPKSRSSSPPLTPHPGSGS*MQKLDFQLKQ
I*PLGHLDYVLEHDVLSSVG*SVTGLQ*RLKTRT
SPLPAQRKKIEKASAQSTAQAI*KAGHPQRWGW
MKTTNQTMRGVTSAASSQLDDCILM*FHNQ*TG
KSG*NLWNMFLGTR*MESLFL*TRGQQLFWHIYH
KNF*AHRVMNIFTKMT*DILQNVIGKFYRREKK
LQLIAINLKSKMVLLSHYGVDGSVS*TLGPRK*
NILSQLTLLF*PTSWKAGTQPSHSSQHPPTAWTA
CCPLEKVAQRGPTPLFQGFQGEPGLGQEK*AE*
LLRKSWKSTG*EGHRLLAVAPAH*TSRVRLPLM
PLLQEARRF*MEGLQTFLPVAYYQARLRRTQVIH
ILIVLLFLVRTPT*V*T*LTTTKDQVVPVMMRQ
QWLSS*ASWKQMLDWVALLTLVTCHGRCKHYML
LWQQL*YQSALLVEFYSL*SLLDKERIAFMY*LH
KSHLRAIDTSQSYYM*LQTKWN*ACSSVSSSLI
IGLAVDSLH*LYILDSVCVEFFNHCAQKHHW*L
LYANGHFRCMVFLHYKEVPHVDISYTNCIIKPFI
LPCKNPLL*IWVKV*CTRQLNIFNKCFPCSI

Frame 2

KVG*WCDI*GRQKVGQGRRCLFTRAGLTAAAAA
GSECGRGRGRSRRATVVLARVYTFGPKLNFSNV
ESWAFIGSDVIGIYARGLPVCRALWFLEEADRL
KRNYKT*KSL*GDQVQRPLTPPKLDLGCKNCDFR
SSNGRPENGHFFNHQ*FHVPGPHRPAFQLSWYQ
WCGLQPQTERQLH*LPRKHGHRQR*PSWKVRIY
RTPRKDKKCKGSSQSD*KAASG*NEQFYR*IGFF
GTNMQRNVQEIR*TYCAKDGCSAHENIKRCHQS
IHRSKLQTNFSIRR*IETPHSQGSRWIFVCRRM
*PREDTLCLRVCLQDPQLQPE*SDWSEFV*LPAS
*RYCQSQGAALLL*HRTPGAAHRCKNWTSS*NR
YNPWAISIMFWSTTFFLL*DEV*QAFSKG*RQG
LPLYLLKEKRSKKLLHNPQHRLFEKLATHKDGAG
*RQRTRQ*GV*PQLPRRNWTTAFSCSSTTSERG
NQGEIYGICFSARDRWKVCFCRPEGNSYFGIFT
TRTSRHIVL*IFSPR*HRTSCRMS*ASFTDERKN
YN*LL*I*NQRWFFYHTTESMVQFHEPLDQGSR
IYCLN*HCCFSQRPGRRGPNLPTAHSIPPQHGQ
HAALWRRWPKEDPPHCSRDSRGNPGWGRKNRPND
C*GNHGNPQDKRVIAF*LWLQPIEHHEYASP*C
LFSRRQEDFKWRDSRHSFQWPTIRPGSGEPRLS
IF**FFYSW*EPPHRYRHD*QRPRIK*SQ***GS
NGCHHEPLGSRCWTGWPC*L**LAMAAVNTTCC
FGNSYSIKVHYWWSFTVCEAYWIRRE*LLCTDF
IKAISEPLIQVNLTICNFRQSGTKPAPVFPHH*L
LG*LWIACINCIFWILFVLNFLIIVHRSIIGSF
YMQMVISDVWCFYTTKKSPMWIFLILIVS*SRL
FFLVRILYYKYGLKYNVLDS*IFLINVSLVL*

Sequence NM_001030273

GGAAAGTAGGTTAGTGGTGCGACATTTAGGGAAGGCAGAAAGTAGGTCAGGGACGGAGGTGCCTGTTTACCCGCGCCGGACTCACCGCCGCCGCCGCCGC
GGGATCCGAGTGCGGGCGCGGGCGCGGGCGCTCCCGGCGAGCCACGGTGGTGCTGGCTAGAGTGTATACGTTTGGACCCAAGCTTAACTTTTCCAATGTG
GAATCCTGGGCCTTCATTGGTTTTTGGAAGAAGCTGACCGCCTGAAAAGAAATTATAAAACATGAAAATCGCTTTGAGGTGACCAAGTCCAGAGGCCCCT
AACTCCTCCCAAGCTGGATCTGGGGTGTAAGAACTGTGACTTCAGATCATCCAATGGCAGACCAGAGAATGGACATTTCTTCAACCATCAGTGATTTCAT
GTCCCCGGGCCCCACCGACCTGCTTTCCAGCTCTCTTGGTACCAGTGGTGTGGATTGCAACCGCAAACGGAAAGGCAGCTCCACTGACTACCATTCACAG
GTCGAATTTGGGGAGCACAATGGCTGGAGGTCAGATGCCCACTAGGAGATGCTATGATTAATATAGAAAGCATGGACACAGACAAAGATGACCCTCATGG
AAGGTTAGAATATACAGAACACCAAGGAAGGATAAAAAATGCAAGGGAAGCTCACAGTCAGATTGAAAAGCGGCGTCGGGATAAAATGAACAGTTTTATA
GATGAATTGGCTTCTTTGGTACCAACATGCAACGCAATGTCCAGGAAATTAGATAAACTTACTGTGCTAAGGATGGCTGTTCAGCACATGAAAACATTAA
GAGGTGCCACCAATCCATACACAGAAGCAAACTACAAACCAACTTTTCTATCAGACGATGAATTGAAACACCTCATTCTCAGGGCAGCAGATGGATTTTT
GTTTGTCGTAGGATGTGACCGAGGGAAGATACTCTTTGTCTCAGAGTCTGTCTTCAAGATCCTCAACTACAGCCAGAATGATCTGATTGGTCAGAGTTTG
TTTGACTACCTGCATCCTAAAGATATTGCCAAAGTCAAGGAGCAGCTCTCCTCCTCTGACACCGCACCCCGGGAGCGGCTCATAGATGCAAAAACTGGAC
TTCCAGTTAAAACAGATATAACCCCTGGGCCATCTCGATTATGTTCTGGAGCACGACGTTCTTTCTTCTGTAGGATGAAGTGTAACAGGCCTTCAGTAAA
GGTTGAAGACAAGGACTTCCCCTCTACCTGCTCAAAGAAAAAAGATCGAAAAAGCTTCTGCACAATCCACAGCACAGGCTATTTGAAAAGCTGGCCACCC
ACAAAGATGGGGCTGGATGAAGACAACGAACCAGACAATGAGGGGTGTAACCTCAGCTGCCTCGTCGCAATTGGACGACTGCATTCTCATGTAGTTCCAC
AACCAGTGAACGGGGAAATCAGGGTGAAATCTATGGAATATGTTTCTCGGCACGCGATAGATGGAAAGTTTGTTTTTGTAGACCAGAGGGCAACAGCTAT
TTTGGCATATTTACCACAAGAACTTCTAGGCACATCGTGTTATGAATATTTTCACCAAGATGACATAGGACATCTTGCAGAATGTCATAGGCAAGTTTTA
CAGACGAGAGAAAAAATTACAACTAATTGCTATAAATTTAAAATCAAAGATGGTTCTTTTATCACACTACGGAGTCGATGGTTCAGTTTCATGAACCCTT
GGACCAAGGAAGTAGAATATATTGTCTCAACTAACACTGTTGTTTTAGCCAACGTCCTGGAAGGCGGGGACCCAACCTTCCCACAGCTCACAGCATCCCC
CCACAGCATGGACAGCATGCTGCCCTCTGGAGAAGGTGGCCCAAAGAGGACCCACCCCACTGTTCCAGGGATTCCAGGGGGAACCCGGGCTGGGGCAGGA
AAAATAGGCCGAATGATTGCTGAGGAAATCATGGAAATCCACAGGATAAGAGGGTCATCGCCTTCTAGCTGTGGCTCCAGCCCATTGAACATCACGAGTA
CGCCTCCCCCTGATGCCTCTTCTCCAGGAGGCAAGAAGATTTTAAATGGAGGGACTCCAGACATTCCTTCCAGTGGCCTACTATCAGGCCAGGCTCAGGA
GAACCCAGGTTATCCATATTCTGATAGTTCTTCTATTCTTGGTGAGAACCCCCACATAGGTATAGACATGATTGACAACGACCAAGGATCAAGTAGTCCC
AGTAATGATGAGGCAGCAATGGCTGTCATCATGAGCCTCTTGGAAGCAGATGCTGGACTGGGTGGCCCTGTTGACTTTAGTGACTTGCCATGGCCGCTGT
AAACACTACATGTTGCTTTGGCAACAGCTATAGTATCAAAGTGCATTACTGGTGGAGTTTTACAGTCTGTGAAGCTTACTGGATAAGGAGAGAATAGCTT
TTATGTACTGACTTCATAAAAGCCATCTCAGAGCCATTGATACAAGTCAATCTTACTATATGTAACTTCAGACAAAGTGGAACTAAGCCTGCTCCAGTGT
TTCCTCATCATTGATTATTGGGCTAGCTGTGGATAGCTTGCATTAATTGTATATTTTGGATTCTGTTTGTGTTGAATTTTTTAATCATTGTGCACAGAAG
CATCATTGGTAGCTTTTATATGCAAATGGTCATTTCAGATGTATGGTGTTTTTACACTACAAAGAAGTCCCCCATGTGGATATTTCTTATACTAATTGTA
TCATAAAGCCGTTTATTCTTCCTTGTAAGAATCCTTTACTATAAATATGGGTTAAAGTATAATGTACTAGACAGTTAAATATTTTTAATAAATGTTTCCC
TTGTTCTATAAA
  • refseq_ARNTL.F4 (forward primer)
  • refseq_ARNTL.R4 (reverse primer)
  • Single exon skipping

Frame 0

GK*VSGATFREGRK*VRDGGACLPAPDSPPPPP
RDPSAGAGAGAPGEPRWCWLECIRLDPSLTFPMW
NPGPSLVFGRS*PPEKKL*NMKIALR*PSPEAP
NSSQAGSGV*EL*LQIIQWQTREWTFLQPSVIS
CPRAPPTCFPALLVPVVWIATANGKAAPLTTIHR
SNLGSTMAGGQMPTRRCYD*YRKHGHRQR*PSW
KVRIYRTPRKDKKCKGSSQSD*KAASG*NEQFY
R*IGFFGTNMQRNVQEIR*TYCAKDGCSAHENIK
RCHQSIHRSKLQTNFSIRR*IETPHSQGSRWIF
VCRRM*PREDTLCLRVCLQDPQLQPE*SDWSEF
V*LPAS*RYCQSQGAALLL*HRTPGAAHRCKNWT
SS*NRYNPWAISIMFWSTTFFLL*DEV*QAFSK
G*RQGLPLYLLKEKRSKKLLHNPQHRLFEKLAT
HKDGAG*RQRTRQ*GV*PQLPRRNWTTAFSCSST
TSERGNQGEIYGICFSARDRWKVCFCRPEGNSY
FGIFTTRTSRHIVL*IFSPR*HRTSCRMS*ASF
TDERKNYN*LL*I*NQRWFFYHTTESMVQFHEPL
DQGSRIYCLN*HCCFSQRPGRRGPNLPTAHSIP
PQHGQHAALWRRWPKEDPPHCSRDSRGNPGWGR
KNRPNDC*GNHGNPQDKRVIAF*LWLQPIEHHEY
ASP*CLFSRRQEDFKWRDSRHSFQWPTIRPGSG
EPRLSIF**FFYSW*EPPHRYRHD*QRPRIK*S
Q***GSNGCHHEPLGSRCWTGWPC*L**LAMAAV
NTTCCFGNSYSIKVHYWWSFTVCEAYWIRRE*L
LCTDFIKAISEPLIQVNLTICNFRQSGTKPAPV
FPHH*LLG*LWIACINCIFWILFVLNFLIIVHRS
IIGSFYMQMVISDVWCFYTTKKSPMWIFLILIV
S*SRLFFLVRILYYKYGLKYNVLDS*IFLINVS
LVL*

Frame 1

ESRLVVRHLGKAESRSGTEVPVYPRRTHRRRRR
GIRVRARARALPASHGGAG*SVYVWTQA*LFQC
GILGLHWFLEEADRLKRNYKT*KSL*GDQVQRPL
TPPKLDLGCKNCDFRSSNGRPENGHFFNHQ*FH
VPGPHRPAFQLSWYQWCGLQPQTERQLH*LPFT
GRIWGAQWLEVRCPLGDAMINIESMDTDKDDPHG
RLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFI
DELASLVPTCNAMSRKLDKLTVLRMAVQHMKTL
RGATNPYTEANYKPTFLSDDELKHLILRAADGFL
FVVGCDRGKILFVSESVFKILNYSQNDLIGQSL
FDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTG
LPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVK
VEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP
TKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVP
QPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAI
LAYLPQELLGTSCYEYFHQDDIGHLAECHRQVL
QTREKITTNCYKFKIKDGSFITLRSRWFSFMNP
WTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASP
HSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAG
KIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITS
TPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQE
NPGYPYSDSSSILGENPHIGIDMIDNDQGSSSP
SNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
*TLHVALATAIVSKCITGGVLQSVKLTG*GENSF
YVLTS*KPSQSH*YKSILLYVTSDKVELSLLQC
FLIIDYWASCG*LALIVYFGFCLC*IF*SLCTE
ASLVAFICKWSFQMYGVFTLQRSPPCGYFLY*LY
HKAVYSSL*ESFTINMG*SIMY*TVKYF**MFP
LFYK

Frame 2

KVG*WCDI*GRQKVGQGRRCLFTRAGLTAAAAA
GSECGRGRGRSRRATVVLARVYTFGPKLNFSNV
ESWAFIGFWKKLTA*KEIIKHENRFEVTKSRGP
*LLPSWIWGVRTVTSDHPMADQRMDISSTISDFM
SPGPTDLLSSSLGTSGVDCNRKRKGSSTDYHSQ
VEFGEHNGWRSDAH*EML*LI*KAWTQTKMTLM
EG*NIQNTKEG*KMQGKLTVRLKSGVGIK*TVL*
MNWLLWYQHATQCPGN*INLLC*GWLFST*KH*
EVPPIHTQKQTTNQLFYQTMN*NTSFSGQQMDF
CLS*DVTEGRYSLSQSLSSRSSTTARMI*LVRVC
LTTCILKILPKSRSSSPPLTPHPGSGS*MQKLD
FQLKQI*PLGHLDYVLEHDVLSSVG*SVTGLQ*
RLKTRTSPLPAQRKKIEKASAQSTAQAI*KAGHP
QRWGWMKTTNQTMRGVTSAASSQLDDCILM*FH
NQ*TGKSG*NLWNMFLGTR*MESLFL*TRGQQL
FWHIYHKNF*AHRVMNIFTKMT*DILQNVIGKFY
RREKKLQLIAINLKSKMVLLSHYGVDGSVS*TL
GPRK*NILSQLTLLF*PTSWKAGTQPSHSSQHP
PTAWTACCPLEKVAQRGPTPLFQGFQGEPGLGQE
K*AE*LLRKSWKSTG*EGHRLLAVAPAH*TSRV
RLPLMPLLQEARRF*MEGLQTFLPVAYYQARLR
RTQVIHILIVLLFLVRTPT*V*T*LTTTKDQVVP
VMMRQQWLSS*ASWKQMLDWVALLTLVTCHGRC
KHYMLLWQQL*YQSALLVEFYSL*SLLDKERIA
FMY*LHKSHLRAIDTSQSYYM*LQTKWN*ACSSV
SSSLIIGLAVDSLH*LYILDSVCVEFFNHCAQK
HHW*LLYANGHFRCMVFLHYKEVPHVDISYTNC
IIKPFILPCKNPLL*IWVKV*CTRQLNIFNKCFP
CSI

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