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Sequences

Sequence NM_001135

GCCAGGTGTGTGGGACTGAAGTTCTTGGAGAAGGGAGTCCAACTCTTCAAGGTGAACTATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATC ACTGCAGCTGTCACTGTAGAAACTTCAGACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGGGTCCTCCTGGGGACCTCCCTCA CCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTGACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAGGA GAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTATCAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGT GACGCCACCTTGGAAGTCCAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAGGACAGCGAGGCCACCCTGGAAG TCGTGGTGAAAGGCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCAT CATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAGATACCCCATCCAC ACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCG CCGAGGAGATGGAGGGTGAGGTCTTTTATGCAACATCTCCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTGGC CACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGCTGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCC CGGCCCAACTGCGGTGGCAACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCCTCATCCCGCTACGACGCCATCT GCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAACTTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATGGA GCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACCGTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCC GAGGAGCCCTTCACGTTTGCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACCAGGCCCTGGGGCTTTCCCACAC CTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGACCTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGGGGGTCGTCTTCCA CTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGCCTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAG GCCGCCTACGAAGCAGGCTATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAGATACCCCATTGTGAGCCCCCGGACCCCATGCGTGGGTG ACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTGCGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGGGGGAGGTGTT CTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCTCACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCC TGGAGCCGCGGCCTGGACAAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGGCCTGCCTGCGGTGGGGACAAGC CAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACGGGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAGGCATTTCAGCGGTTCC TTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGGATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTA GAAGAGGAGACAACTGCTGTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACAGAATGGGAACCAGCCTATACCC CAGTGGGCACATCCCCGCTGCCAGGGATCCTTCCTACTTGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTGCC CTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCCCCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCA GTGGAGCTGTTCCCCTCAGAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAGCCGTATACACCTTCACCCCCCG TGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAATCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTTGA CTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGACTCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTG GAAAGTGGACTACCCTCAGGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGAGCTGAGATCCTAGAGGGCTCTG CCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGAGAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAAGT TCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTT CCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGG ACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGC CCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT CTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTC CTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGA CATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCC CCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTC TAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCC TTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGATGAG ATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCTACCT CTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCTGTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGT TGTAGAGACTTCTGCCTCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCTGGAGTAGAGGACCTCAGCAGGCTC CCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCTGGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCTGAAG TAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCTTCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGA CTTGGTGGGGTCAGCTTCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCAGAAACAAGTGGTCTTCCCTCTGGA TTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGTGGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCCCTAG TGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGGAGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACT GCCCTCCAGTGAGCTGGACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCTGGGTCTCCTGATGTCAGTGGGGAA ATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCAGGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCTGGAC AACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTTGGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCT CAGTGGGCAGCCTTCAGGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACGAGTGGCAGCGGTGAATCTTCTGGG ATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCCCCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCCGGAG AGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGAACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAG TGGCCTACCAAGTGGCATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGAGCATATTATGGCAGTGGAACTCCA TCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACTTTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGCATTT TAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGATTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAG CGGAGAGCCACCAGGTACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTAGCCATGGGCACCAGTGGAGAGGCC TCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAGTTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTGACAC ACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGTGGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATC AGTCCCAGAATCTAGCAGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGCAGAGAAGATTCTGGGTCCCCTGAT CTGAGTGAAACCACCTCTGCATTCCACGAAGCTAACCTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAGGCGT CCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAGGCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAG GACTGAAATCAGCGGAGACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCTGAGTGGACCCAGCAGACCCAGCGC CCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGCCTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCTTCCA TCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAGACCAGGAGGTATGTGAGGAGGGCTGGAACAAGTACCAGGGCCACTGTTACCG CCACTTCCCGGACCGCGAGACCTGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCGAGGAGCAGGAGTTT GTCAACAACAATGCCCAAGACTACCAGTGGATCGGCCTGAACGACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCCCATGCAATTTGAGA ACTGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATCTGGCACGAGAAGGGCGAGTGGAATGATGTTCCCTGCAA TTACCACCTCCCCTTCACGTGTAAAAAGGGCACAGCCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCACCCTCGGAGGAGCCGCCCCAGC ACAGCCCACTGAGAAGAGCTTCCAGGACGCACCCAGGACGCTGAGCCCAGGAGCCTGCCAGGCTGACGTGCATCCCACCCAGACGGTGTCCTCTTCTTGT CGCTTTTTGTCATATAAGGAATCCCATTAAA

refseq_AGC1.F1 (forward primer)
refseq_AGC1.R1 (reverse primer)
Single exon skipping

Frame 0

ARCVGLKFLEKGVQLFKVNYDHFTLGFRDSEGH HCSCHCRNFRP*QLAECQHPPTVPAEGPPGDLPH HPLLFHRPHAPCDHRPFYRPTGPKNQVEPCVQG EGGSAAGGH*RARAGQQCLSGQGLTAQLPGHPQ *RHLGSPEPALQ*LWGLPLRGDAWHRGQRGHPGS RGERHRVPLQSHLYTLHPRL*QGAAGLPAEQCH HCHA*AAAGRLRRRLPPV*RRLAG*PDCQIPHP HSPGRLLWRQG*VSWCEDVWHPRHQRDL*CVLLR RGDGG*GLLCNISREVHLPGSSQ*VPAAGCPAG HHGPALPGLAGWHGHVQRRLAGRPQRALPHLQG PAQLRWQPPGREDRLRACQPDGLPRPLIPLRRHL LHR*RLCGHPRKLLWSGG*GGHHRPDSDLA*HG AATASKHH*G*SPRQRDPYRKAHLRGLPQSPGT RGALHVCP*NRGHCLR*G*E*DWRGHQALGLSHT WPGPCHGIHQ*GPRRAGDRCPWAAAFARGGRLP LPPGTHPLLADL*GGTAGLPAHGGGHCLAGAAP GRLRSRL*AV*RRLAAGPDRQIPHCEPPDPMRG* QGQQPRGQDLWRAPINRDLRCLLLCRQT*GGGV LRHTP*AVHLPGSTGVL*ISQCYAGHHGPALRR LEPRPGQVLCRLAGRRQPPLPHRHPKACLRWGQA RRENGLPLP*PDGPPRPTVPAPCLLLPRHFSGS FSRRRRGWHTHITLWCGGVDRDPSGSWCGCCPR RRGDNCCTLRGDYCHPRVHHRARKPDRMGTSLYP SGHIPAARDPSYLASHWRSNRGKYRRPFCN*SA LCLRGTIPLRGAIPLRGAIPLRGTIPLSEAIPL SGAVPLRGAIPLQGAIPLRGTISLGRAVYTFTPR AQLD*AAQLWGGIWGP*CQW*LHRQWRCFRTP* LQWAAVRGQGKWTALWRPGLQWSYFHSGLRPAC GKWTTLRG*REN*VAQHSYGW*TALWS*DPRGLC LWSWGSQWTSFWRSSRDLCLWSRRPQWASFWRS SRDHCPWSRGHQRASFWRSSRDHCPWSRGHQRA SFWRSSRDHCPWSRGHQRASFWRSSRDHCPWSRG HQRASFWRSSRDHCPWSRGHQRASFWRSSRDHC PWSRGHQRASFWRSSRDRCPWSRGHQRASFWRS SRDRCPWSRGHQRASFWRSSRDRCPWSRGHQRAS FWRSSRDRCPWSRGHQRASFWRSSRDRCPWSRG HQRASFWRSSRDRCPWSRGHQRASFWRSSRDCC PWSRGHQRASFWRSSRDCCPWSRGHQRASFWRSS RDCCPWSRGHQRASFWRSSRDCCPWSRGHQRAS FWRSSRDYCPWSRGDQRASFWRSSRDYCPWSR* DQWASFWRSSRDYCPWSRGDQRASFWRSSRDFYL CGRGPQWTSFWRRSSRDFCLWSRGHQWASFWRG CRDFCLWNRGCQ*TSFRRRSRDLCFWSRGPQQA PFWRRSSRDFCLWIWGPQWTSFWRRRSRDLCF*S RD*PQWASFWKGGSRDFSFWS*GPQWVAFWKRR LGGVSFWRLGLGQTAFWNSRKWASSRNKWSSLW I*W*VFWGGPWKWPTLWPA*L*WTSIWIPNCFPS GFYIGGSGHSLHCK*TGREGNHWHQWCRRNIWT ALQ*AGH*WES*WTPFRN*TQWPSIWVS*CQWG NTWTLWCQWTAIRVS*H*WGNIWSD*A*RAVLWT TRY*WRSIWSSLWH*STLWHN*SEWRNIWGP*S QWAAFRVTRVQWGNIRSP*PGFWYHEWQR*IFW DYICGHQFG*SGPYYI*RRRRLRVCGTQWPPFRR GRSVRQIWDGGCQWTVFWNSRFQWVYIPDSGIQ WPTKWHS*GQWRILQS*DWEQPALGSILWQWNS I*FPHCLSCRQNFGGICNPGSNSPRGRRRAFWHF RTQWCSFWSTRHVWGAFWISGPKWAAVRADRAQ RRATRYSIF*WGFCQHHQCKWRILCSHGHQWRG LRTSRSYFNHF*VRGGCY*TNYFSGTRPKAPCDT HTPAF*VQWKSLHSWGH*WSYPSAPWVWSRSII SPRI*Q*DVRLS*SWVRGICRP*GQQRRFWVP* SE*NHLCIPRS*P*EILWPRSERQHFDISRRRGV RCPRSEWRIHHHQ*CGDRGTRLAFSHSHGFWRQ D*NQRRPVWSHLAAGRCHQHQHPRV*VDPADPA PCRDASRN*VLKPPVLRRRDSHSRNSHLPNRCFH PSFSGMET*IRINCCRPGGM*GGLEQVPGPLLP PLPGPRDLGGC*APVSGAAVTPEQHRHPRGAGV CQQQCPRLPVDRPERQDHRRGLPLVRWTPHAI*E LAPQPA*QLFCRWRGLCGDDLAREGRVE*CSLQ LPPPLHV*KGHSHHLQTQTTEAELTAPSEEPPQ HSPLRRASRTHPGR*AQEPARLTCIPPRRCPLLV AFCHIRNPIK

Frame 1

PGVWD*SSWRRESNSSR*TMTTLLWVFVTLRVI TAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSL TIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKE KEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPS DATLEVQSLRSNDSGVYRCEVMHGIEDSEATLE VVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAI IATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCF AEEMEGEVFYATSPEKFTFQEAANECRRLGARLA TTGQLYLAWQAGMDMCSAGWLADRSVRYPISKA RPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAI CYTGEDFVDIPENFFGVGGEEDITVQTVTWPDME LPLPRNITEGEARGSVILTVKPIFEVSPSPLEP EEPFTFAPEIGATAFAEVENETGEATRPWGFPT PGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFH YRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQ AAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVG DKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVF FATRLEQFTFQEALEFCESHNATLATTGQLYAA WSRGLDKCYAGWLADGSLRYPIVTPRPACGGDK PGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVP SPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPV EEETTAVPSGETTAILEFTTEPENQTEWEPAYT PVGTSPLPGILPTWPPTGAATEESTEGPSATEVP SASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPS VELFPSEEPFPSKEPSPSEEPSASEEPYTPSPP VPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLD FSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPV ESGLPSGDEERIEWPSTPTVGELPSGAEILEGS ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEV LETTAPGVEDISGLPSGEVLETTAPGVEDISGL PSGEVLETTAPGVEDISGLPSGEVLETTAPGVE DISGLPSGEVLETTAPGVEDISGLPSGEVLETTA PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETAAPGVEDISGL PSGEVLETAAPGVEDISGLPSGEVLETAAPGVED ISGLPSGEVLETAAPGVEDISGLPSGEVLETAA PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETAAPGVEDISGLP SGEVLETTAPGVEEISGLPSGEVLETTAPGVDE ISGLPSGEVLETTAPGVEEISGLPSGEVLETST SAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEV VETSASGIEDVSELPSGEGLETSASGVEDLSRL PSGEEVLEISASGFGDLSGLPSGGEGLETSASE VGTDLSGLPSGREGLETSASGAEDLSGLPSGKED LVGSASGDLDLGKLPSGTLGSGQAPETSGLPSG FSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSL VDSTLVEVVTASTASELEGRGTIGISGAGEISGL PSSELDISGRASGLPSGTELSGQASGSPDVSGE IPGLFGVSGQPSGFPDTSGETSGVTELSGLSSG QPGISGEASGVLYGTSQPFGITDLSGETSGVPDL SGQPSGLPGFSGATSGVPDLVSGTTSGSGESSG ITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSG EADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFS GLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTP SSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGI LELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPS GEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA SGLPEVTLITSEFVEGVTEPTISQELGQRPPVT HTPQLFESSGKVSTAGDISGATPVLPGSGVEVSS VPESSSETSAYPEAGFGASAAPEASREDSGSPD LSETTSAFHEANLERSSGLGVSGSTLTFQEGEA SAAPEVSGESTTTSDVGTEAPGLPSATPTASGDR TEISGDLSGHTSQLGVVISTSIPESEWTQQTQR PAETHLEIESSSLLYSGEETHTVETATSPTDAS IPASPEWKRESESTAADQEVCEEGWNKYQGHCYR HFPDRETWVDAERRCREQQSHLSSIVTPEEQEF VNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFE NWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCN YHLPFTCKKGTATTYKRRLQKRSSRHPRRSRPS TAH*EELPGRTQDAEPRSLPG*RASHPDGVLFL SLFVI*GIPL

Frame 2

QVCGTEVLGEGSPTLQGEL*PLYSGFS*L*GSS LQLSL*KLQTMTTR*VSASPNRPR*GSSWGPPS PSPAISSTPCTL*PPPLLPPHWPQESSGAVCPR RRR*CCWWPLKGACGSTVPIRTRSHCPTTRPSPV TPPWKSRACAPMTLGSTAAR*CMASRTARPPWK SW*KASCSITEPSLHATPSTLTGRSGPACRTVP SLPRLSSCRPPTKTASTSVTPAGWLTRLSDTPST LPGKAAMETRMSFLV*GRMASETPTRPMMCTAS PRRWRVRSFMQHLQRSSPSRKQPMSAGGWVPGW PPRASSTWPGRLAWTCAAPAGWPTAACATPSPRP GPTAVATSWA*GPSTCMPTRRATPTPHPATTPS ATQVKTLWTSQKTSLEWGVRRTSPSRQ*PGLTW SCHCLETSLRVKPEAA*SLP*SPSSRSPPVPWNP RSPSRLPLK*GPLPSLRLRMRLERPPGPGAFPH LAWALPRHSPVRTSSCR*PLSLGSRICQGGSSS TTARDPPATR*PLRRHSRPACARGRSLPRRSSSR PPTKQAMSSVTPAGCGTRPSDTPL*APGPHAWV TRTAAQGSGPMACAHQQRPTMSTAL*TDLRGRC SSPHALSSSPSRKHWSSVNLTMLRWPPRASSTPP GAAAWTSAMPAGWPTAASATPSSPQGLPAVGTS QA*ERSTSTLTRRASQTHCPGTMPSASEAFQRF LLQEKKRVAHPHHPLVWRSGS*PKWFLVWLLSP* KRRQLLYPQGRLLPS*SSPPSQKTRQNGNQPIP QWAHPRCQGSFLLGLPLAQQQRKVQKALLQLKC PLPQRNHPPQRCHSPQRSHPPQRNHSPQ*GHSPQ WSCSPQRSHSPPRSHPPQRNHQPRKSRIHLHPP CPAGLSCPALGRNLGPLMSVVTSQAVEMFQDTL TSVGSCQGTGQVDCPLETWTPVVLLPQWAQACLW KVDYPQGMKRELSGPALLRLVNCPLELRS*RAL PLELGISVDFLLEKF*RPLPLE*ETSVGFLLEK F*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RPL PLE*RTSAGFLLEKF*RPLPLE*RTSAGFLLEKF *RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RLLP LE*RTSAGFLLEKF*RLLPLE*RTSAGFLLEKF *RLLPLE*RTSAGFLLEKF*RLLPLE*RTSAGF LLEKF*RLLPLE*RRSAGFLLEKF*RLLPLE*MR SVGFLLEKF*RLLPLE*RRSAGFLLEKF*RLLP LR*GTSVDFLLEEKF*RFLSLE*RTSVGFLLER L*RLLPLE*RMSVNFLQEKV*RPLLLE*RTSAGS LLEKKF*RFLPLDLGTSVDFLLEEKV*RPLLLK *GLTSVGFLLEGRV*RLQLLELRTSVGCLLEKK TWWGQLLETWTWANCLLEL*EVGKLQKQVVFPLD LVVSILGWTLEVAHPLACLTLVDFHLDSQLFP* WILHWWKWSQPPLQVNWKGGEPLASVVQEKYLD CPPVSWTLVGELVDSLQELNSVAKHLGLLMSVGK YLDSLVSVDSHQGFLTLVGKHLE*LSLAGCPLD NQVLVEKHLEFFMALVNPLA*LI*VEKHLGSLI SVGSLQGYQGSVGQHQESLTWFLVPRVAAVNLLG LHLWTPVWLKWPLLHLKKKKA*GLWNSVASLPE RQICQANLGWWMSVDSFLEQSIPVGLHPRLRNS VAYQVA*LRSVENPPELRLGAACPREHIMAVELH LVSPLSLL*TELWWNL*PRLQQPKRQEKGLLAF *NSVVLILEHQTCLGSILDFWT*VGCSPG**SP AESHQVLHILVGILPAPPM*VENPL*PWAPVERP QDFQKLL*SLLSSWRVLLNQLFLRN*AKGPL*H THPSFLSPVEKSPQLGTLVELPQCSLGLE*KYH QSQNLAVRRPPILKLGSGHLPPLRPAEKILGPLI *VKPPLHSTKLTLRDPLA*E*AAAL*HFKKARR PLPQK*VENPPPPVMWGQRHQACLQPLPRLLET GLKSAETCLVTPRSWALSSAPASQSLSGPSRPSA LQRRI*KLSPQASCTQEKRLTQSKQPPPQQMLP SQLLRNGNVNQNQLLQTRRYVRRAGTSTRATVT ATSRTARPGWMLSAGVGSSSHT*AASSPPRSRSL STTMPKTTSGSA*TTGPSKGTSAGQMDTPCNLR TGAPTSLTTFLPLERTVW**SGTRRASGMMFPA ITTSPSRVKRAQPPPTNADYRSGAHGTLGGAAPA QPTEKSFQDAPRTLSPGACQADVHPTQTVSSSC RFLSYKESH*

Sequence NM_013227

GCCAGGTGTGTGGGACTGAAGTTCTTGGAGAAGGGAGTCCAACTCTTCAAGGTGAACTATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATC ACTGCAGCTGTCACTGTAGAAACTTCAGACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGGGTCCTCCTGGGGACCTCCCTCA CCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTGACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAGGA GAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTATCAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGT GACGCCACCTTGGAAGTCCAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAGGACAGCGAGGCCACCCTGGAAG TCGTGGTGAAAGGCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCAT CATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAGATACCCCATCCAC ACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCG CCGAGGAGATGGAGGGTGAGGTCTTTTATGCAACATCTCCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTGGC CACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGCTGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCC CGGCCCAACTGCGGTGGCAACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCCTCATCCCGCTACGACGCCATCT GCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAACTTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATGGA GCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACCGTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCC GAGGAGCCCTTCACGTTTGCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACCAGGCCCTGGGGCTTTCCCACAC CTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGACCTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGGGGGTCGTCTTCCA CTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGCCTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAG GCCGCCTACGAAGCAGGCTATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAGATACCCCATTGTGAGCCCCCGGACCCCATGCGTGGGTG ACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTGCGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGGGGGAGGTGTT CTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCTCACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCC TGGAGCCGCGGCCTGGACAAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGGCCTGCCTGCGGTGGGGACAAGC CAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACGGGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAGGCATTTCAGCGGTTCC TTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGGATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTA GAAGAGGAGACAACTGCTGTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACAGAATGGGAACCAGCCTATACCC CAGTGGGCACATCCCCGCTGCCAGGGATCCTTCCTACTTGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTGCC CTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCCCCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCA GTGGAGCTGTTCCCCTCAGAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAGCCGTATACACCTTCACCCCCCG TGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAATCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTTGA CTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGACTCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTG GAAAGTGGACTACCCTCAGGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGAGCTGAGATCCTAGAGGGCTCTG CCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGAGAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAAGT TCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTT CCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGG ACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGC CCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT CTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTC CTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGA CATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCC CCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTC TAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCC TTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGATGAG ATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCTACCT CTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCTGTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGT TGTAGAGACTTCTGCCTCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCTGGAGTAGAGGACCTCAGCAGGCTC CCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCTGGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCTGAAG TAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCTTCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGA CTTGGTGGGGTCAGCTTCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCAGAAACAAGTGGTCTTCCCTCTGGA TTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGTGGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCCCTAG TGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGGAGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACT GCCCTCCAGTGAGCTGGACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCTGGGTCTCCTGATGTCAGTGGGGAA ATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCAGGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCTGGAC AACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTTGGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCT CAGTGGGCAGCCTTCAGGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACGAGTGGCAGCGGTGAATCTTCTGGG ATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCCCCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCCGGAG AGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGAACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAG TGGCCTACCAAGTGGCATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGAGCATATTATGGCAGTGGAACTCCA TCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACTTTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGCATTT TAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGATTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAG CGGAGAGCCACCAGGTACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTAGCCATGGGCACCAGTGGAGAGGCC TCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAGTTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTGACAC ACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGTGGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATC AGTCCCAGAATCTAGCAGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGCAGAGAAGATTCTGGGTCCCCTGAT CTGAGTGAAACCACCTCTGCATTCCACGAAGCTAACCTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAGGCGT CCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAGGCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAG GACTGAAATCAGCGGAGACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCTGAGTGGACCCAGCAGACCCAGCGC CCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGCCTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCTTCCA TCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAGCCCCCGCCAGGTCCTGTGCAGAGGAGCCCTGTGGAGCTGGGACCTGCAAGGA GACAGAGGGACACGTCATATGCCTGTGCCCCCCTGGCTACACTGGCGAGCACTGTAACATAGACCAGGAGGTATGTGAGGAGGGCTGGAACAAGTACCAG GGCCACTGTTACCGCCACTTCCCGGACCGCGAGACCTGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCG AGGAGCAGGAGTTTGTCAACAACAATGCCCAAGACTACCAGTGGATCGGCCTGAACGACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCC CATGCAATTTGAGAACTGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATCTGGCACGAGAAGGGCGAGTGGAAT GATGTTCCCTGCAATTACCACCTCCCCTTCACGTGTAAAAAGGGCACAGTGGCCTGCGGAGAGCCCCCTGTGGTGGAGCATGCCAGGACCTTCGGGCAGA AGAAGGACCGGTATGAGATCAATTCCCTGGTGCGGTACCAGTGCACAGAGGGGTTTGTCCAGCGCCACATGCCCACCATCCGGTGCCAGCCCAGCGGGCA CTGGGAGGAGCCTCAGATCACCTGCACAGACCCCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCACCCTCGGAGGAGCCGCCCCAGCACA GCCCACTGAGAAGAGCTTCCAGGACGCACCCAGGACGCTGAGCCCAGGAGCCTGCCAGGCTGACGTGCATCCCACCCAGACGGTGTCCTCTTCTTGTCGC TTTTTGTCATATAAGGAATCCCATTAAA

refseq_AGC1.F1 (forward primer)
refseq_AGC1.R1 (reverse primer)
Single exon skipping

Frame 0

ARCVGLKFLEKGVQLFKVNYDHFTLGFRDSEGH HCSCHCRNFRP*QLAECQHPPTVPAEGPPGDLPH HPLLFHRPHAPCDHRPFYRPTGPKNQVEPCVQG EGGSAAGGH*RARAGQQCLSGQGLTAQLPGHPQ *RHLGSPEPALQ*LWGLPLRGDAWHRGQRGHPGS RGERHRVPLQSHLYTLHPRL*QGAAGLPAEQCH HCHA*AAAGRLRRRLPPV*RRLAG*PDCQIPHP HSPGRLLWRQG*VSWCEDVWHPRHQRDL*CVLLR RGDGG*GLLCNISREVHLPGSSQ*VPAAGCPAG HHGPALPGLAGWHGHVQRRLAGRPQRALPHLQG PAQLRWQPPGREDRLRACQPDGLPRPLIPLRRHL LHR*RLCGHPRKLLWSGG*GGHHRPDSDLA*HG AATASKHH*G*SPRQRDPYRKAHLRGLPQSPGT RGALHVCP*NRGHCLR*G*E*DWRGHQALGLSHT WPGPCHGIHQ*GPRRAGDRCPWAAAFARGGRLP LPPGTHPLLADL*GGTAGLPAHGGGHCLAGAAP GRLRSRL*AV*RRLAAGPDRQIPHCEPPDPMRG* QGQQPRGQDLWRAPINRDLRCLLLCRQT*GGGV LRHTP*AVHLPGSTGVL*ISQCYAGHHGPALRR LEPRPGQVLCRLAGRRQPPLPHRHPKACLRWGQA RRENGLPLP*PDGPPRPTVPAPCLLLPRHFSGS FSRRRRGWHTHITLWCGGVDRDPSGSWCGCCPR RRGDNCCTLRGDYCHPRVHHRARKPDRMGTSLYP SGHIPAARDPSYLASHWRSNRGKYRRPFCN*SA LCLRGTIPLRGAIPLRGAIPLRGTIPLSEAIPL SGAVPLRGAIPLQGAIPLRGTISLGRAVYTFTPR AQLD*AAQLWGGIWGP*CQW*LHRQWRCFRTP* LQWAAVRGQGKWTALWRPGLQWSYFHSGLRPAC GKWTTLRG*REN*VAQHSYGW*TALWS*DPRGLC LWSWGSQWTSFWRSSRDLCLWSRRPQWASFWRS SRDHCPWSRGHQRASFWRSSRDHCPWSRGHQRA SFWRSSRDHCPWSRGHQRASFWRSSRDHCPWSRG HQRASFWRSSRDHCPWSRGHQRASFWRSSRDHC PWSRGHQRASFWRSSRDRCPWSRGHQRASFWRS SRDRCPWSRGHQRASFWRSSRDRCPWSRGHQRAS FWRSSRDRCPWSRGHQRASFWRSSRDRCPWSRG HQRASFWRSSRDRCPWSRGHQRASFWRSSRDCC PWSRGHQRASFWRSSRDCCPWSRGHQRASFWRSS RDCCPWSRGHQRASFWRSSRDCCPWSRGHQRAS FWRSSRDYCPWSRGDQRASFWRSSRDYCPWSR* DQWASFWRSSRDYCPWSRGDQRASFWRSSRDFYL CGRGPQWTSFWRRSSRDFCLWSRGHQWASFWRG CRDFCLWNRGCQ*TSFRRRSRDLCFWSRGPQQA PFWRRSSRDFCLWIWGPQWTSFWRRRSRDLCF*S RD*PQWASFWKGGSRDFSFWS*GPQWVAFWKRR LGGVSFWRLGLGQTAFWNSRKWASSRNKWSSLW I*W*VFWGGPWKWPTLWPA*L*WTSIWIPNCFPS GFYIGGSGHSLHCK*TGREGNHWHQWCRRNIWT ALQ*AGH*WES*WTPFRN*TQWPSIWVS*CQWG NTWTLWCQWTAIRVS*H*WGNIWSD*A*RAVLWT TRY*WRSIWSSLWH*STLWHN*SEWRNIWGP*S QWAAFRVTRVQWGNIRSP*PGFWYHEWQR*IFW DYICGHQFG*SGPYYI*RRRRLRVCGTQWPPFRR GRSVRQIWDGGCQWTVFWNSRFQWVYIPDSGIQ WPTKWHS*GQWRILQS*DWEQPALGSILWQWNS I*FPHCLSCRQNFGGICNPGSNSPRGRRRAFWHF RTQWCSFWSTRHVWGAFWISGPKWAAVRADRAQ RRATRYSIF*WGFCQHHQCKWRILCSHGHQWRG LRTSRSYFNHF*VRGGCY*TNYFSGTRPKAPCDT HTPAF*VQWKSLHSWGH*WSYPSAPWVWSRSII SPRI*Q*DVRLS*SWVRGICRP*GQQRRFWVP* SE*NHLCIPRS*P*EILWPRSERQHFDISRRRGV RCPRSEWRIHHHQ*CGDRGTRLAFSHSHGFWRQ D*NQRRPVWSHLAAGRCHQHQHPRV*VDPADPA PCRDASRN*VLKPPVLRRRDSHSRNSHLPNRCFH PSFSGMET*IRINCCSPRQVLCRGALWSWDLQG DRGTRHMPVPPWLHWRAL*HRPGGM*GGLEQVP GPLLPPLPGPRDLGGC*APVSGAAVTPEQHRHPR GAGVCQQQCPRLPVDRPERQDHRRGLPLVRWTP HAI*ELAPQPA*QLFCRWRGLCGDDLAREGRVE *CSLQLPPPLHV*KGHSGLRRAPCGGACQDLRAE EGPV*DQFPGAVPVHRGVCPAPHAHHPVPAQRA LGGASDHLHRPHHLQTQTTEAELTAPSEEPPQH SPLRRASRTHPGR*AQEPARLTCIPPRRCPLLVA FCHIRNPIK

Frame 1

PGVWD*SSWRRESNSSR*TMTTLLWVFVTLRVI TAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSL TIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKE KEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPS DATLEVQSLRSNDSGVYRCEVMHGIEDSEATLE VVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAI IATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCF AEEMEGEVFYATSPEKFTFQEAANECRRLGARLA TTGQLYLAWQAGMDMCSAGWLADRSVRYPISKA RPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAI CYTGEDFVDIPENFFGVGGEEDITVQTVTWPDME LPLPRNITEGEARGSVILTVKPIFEVSPSPLEP EEPFTFAPEIGATAFAEVENETGEATRPWGFPT PGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFH YRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQ AAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVG DKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVF FATRLEQFTFQEALEFCESHNATLATTGQLYAA WSRGLDKCYAGWLADGSLRYPIVTPRPACGGDK PGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVP SPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPV EEETTAVPSGETTAILEFTTEPENQTEWEPAYT PVGTSPLPGILPTWPPTGAATEESTEGPSATEVP SASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPS VELFPSEEPFPSKEPSPSEEPSASEEPYTPSPP VPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLD FSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPV ESGLPSGDEERIEWPSTPTVGELPSGAEILEGS ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEV LETTAPGVEDISGLPSGEVLETTAPGVEDISGL PSGEVLETTAPGVEDISGLPSGEVLETTAPGVE DISGLPSGEVLETTAPGVEDISGLPSGEVLETTA PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETAAPGVEDISGL PSGEVLETAAPGVEDISGLPSGEVLETAAPGVED ISGLPSGEVLETAAPGVEDISGLPSGEVLETAA PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETAAPGVEDISGLP SGEVLETTAPGVEEISGLPSGEVLETTAPGVDE ISGLPSGEVLETTAPGVEEISGLPSGEVLETST SAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEV VETSASGIEDVSELPSGEGLETSASGVEDLSRL PSGEEVLEISASGFGDLSGLPSGGEGLETSASE VGTDLSGLPSGREGLETSASGAEDLSGLPSGKED LVGSASGDLDLGKLPSGTLGSGQAPETSGLPSG FSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSL VDSTLVEVVTASTASELEGRGTIGISGAGEISGL PSSELDISGRASGLPSGTELSGQASGSPDVSGE IPGLFGVSGQPSGFPDTSGETSGVTELSGLSSG QPGISGEASGVLYGTSQPFGITDLSGETSGVPDL SGQPSGLPGFSGATSGVPDLVSGTTSGSGESSG ITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSG EADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFS GLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTP SSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGI LELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPS GEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA SGLPEVTLITSEFVEGVTEPTISQELGQRPPVT HTPQLFESSGKVSTAGDISGATPVLPGSGVEVSS VPESSSETSAYPEAGFGASAAPEASREDSGSPD LSETTSAFHEANLERSSGLGVSGSTLTFQEGEA SAAPEVSGESTTTSDVGTEAPGLPSATPTASGDR TEISGDLSGHTSQLGVVISTSIPESEWTQQTQR PAETHLEIESSSLLYSGEETHTVETATSPTDAS IPASPEWKRESESTAAAPARSCAEEPCGAGTCKE TEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQ GHCYRHFPDRETWVDAERRCREQQSHLSSIVTP EEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHP MQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWN DVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQ KKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGH WEEPQITCTDPTTYKRRLQKRSSRHPRRSRPST AH*EELPGRTQDAEPRSLPG*RASHPDGVLFLS LFVI*GIPL

Frame 2

QVCGTEVLGEGSPTLQGEL*PLYSGFS*L*GSS LQLSL*KLQTMTTR*VSASPNRPR*GSSWGPPS PSPAISSTPCTL*PPPLLPPHWPQESSGAVCPR RRR*CCWWPLKGACGSTVPIRTRSHCPTTRPSPV TPPWKSRACAPMTLGSTAAR*CMASRTARPPWK SW*KASCSITEPSLHATPSTLTGRSGPACRTVP SLPRLSSCRPPTKTASTSVTPAGWLTRLSDTPST LPGKAAMETRMSFLV*GRMASETPTRPMMCTAS PRRWRVRSFMQHLQRSSPSRKQPMSAGGWVPGW PPRASSTWPGRLAWTCAAPAGWPTAACATPSPRP GPTAVATSWA*GPSTCMPTRRATPTPHPATTPS ATQVKTLWTSQKTSLEWGVRRTSPSRQ*PGLTW SCHCLETSLRVKPEAA*SLP*SPSSRSPPVPWNP RSPSRLPLK*GPLPSLRLRMRLERPPGPGAFPH LAWALPRHSPVRTSSCR*PLSLGSRICQGGSSS TTARDPPATR*PLRRHSRPACARGRSLPRRSSSR PPTKQAMSSVTPAGCGTRPSDTPL*APGPHAWV TRTAAQGSGPMACAHQQRPTMSTAL*TDLRGRC SSPHALSSSPSRKHWSSVNLTMLRWPPRASSTPP GAAAWTSAMPAGWPTAASATPSSPQGLPAVGTS QA*ERSTSTLTRRASQTHCPGTMPSASEAFQRF LLQEKKRVAHPHHPLVWRSGS*PKWFLVWLLSP* KRRQLLYPQGRLLPS*SSPPSQKTRQNGNQPIP QWAHPRCQGSFLLGLPLAQQQRKVQKALLQLKC PLPQRNHPPQRCHSPQRSHPPQRNHSPQ*GHSPQ WSCSPQRSHSPPRSHPPQRNHQPRKSRIHLHPP CPAGLSCPALGRNLGPLMSVVTSQAVEMFQDTL TSVGSCQGTGQVDCPLETWTPVVLLPQWAQACLW KVDYPQGMKRELSGPALLRLVNCPLELRS*RAL PLELGISVDFLLEKF*RPLPLE*ETSVGFLLEK F*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RPL PLE*RTSAGFLLEKF*RPLPLE*RTSAGFLLEKF *RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RLLP LE*RTSAGFLLEKF*RLLPLE*RTSAGFLLEKF *RLLPLE*RTSAGFLLEKF*RLLPLE*RTSAGF LLEKF*RLLPLE*RRSAGFLLEKF*RLLPLE*MR SVGFLLEKF*RLLPLE*RRSAGFLLEKF*RLLP LR*GTSVDFLLEEKF*RFLSLE*RTSVGFLLER L*RLLPLE*RMSVNFLQEKV*RPLLLE*RTSAGS LLEKKF*RFLPLDLGTSVDFLLEEKV*RPLLLK *GLTSVGFLLEGRV*RLQLLELRTSVGCLLEKK TWWGQLLETWTWANCLLEL*EVGKLQKQVVFPLD LVVSILGWTLEVAHPLACLTLVDFHLDSQLFP* WILHWWKWSQPPLQVNWKGGEPLASVVQEKYLD CPPVSWTLVGELVDSLQELNSVAKHLGLLMSVGK YLDSLVSVDSHQGFLTLVGKHLE*LSLAGCPLD NQVLVEKHLEFFMALVNPLA*LI*VEKHLGSLI SVGSLQGYQGSVGQHQESLTWFLVPRVAAVNLLG LHLWTPVWLKWPLLHLKKKKA*GLWNSVASLPE RQICQANLGWWMSVDSFLEQSIPVGLHPRLRNS VAYQVA*LRSVENPPELRLGAACPREHIMAVELH LVSPLSLL*TELWWNL*PRLQQPKRQEKGLLAF *NSVVLILEHQTCLGSILDFWT*VGCSPG**SP AESHQVLHILVGILPAPPM*VENPL*PWAPVERP QDFQKLL*SLLSSWRVLLNQLFLRN*AKGPL*H THPSFLSPVEKSPQLGTLVELPQCSLGLE*KYH QSQNLAVRRPPILKLGSGHLPPLRPAEKILGPLI *VKPPLHSTKLTLRDPLA*E*AAAL*HFKKARR PLPQK*VENPPPPVMWGQRHQACLQPLPRLLET GLKSAETCLVTPRSWALSSAPASQSLSGPSRPSA LQRRI*KLSPQASCTQEKRLTQSKQPPPQQMLP SQLLRNGNVNQNQLLQPPPGPVQRSPVELGPAR RQRDTSYACAPLATLASTVT*TRRYVRRAGTSTR ATVTATSRTARPGWMLSAGVGSSSHT*AASSPP RSRSLSTTMPKTTSGSA*TTGPSKGTSAGQMDT PCNLRTGAPTSLTTFLPLERTVW**SGTRRASGM MFPAITTSPSRVKRAQWPAESPLWWSMPGPSGR RRTGMRSIPWCGTSAQRGLSSATCPPSGASPAG TGRSLRSPAQTPPPTNADYRSGAHGTLGGAAPAQ PTEKSFQDAPRTLSPGACQADVHPTQTVSSSCR FLSYKESH*