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Sequences

Sequence NM_001135

GCCAGGTGTGTGGGACTGAAGTTCTTGGAGAAGGGAGTCCAACTCTTCAAGGTGAACTATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATC
ACTGCAGCTGTCACTGTAGAAACTTCAGACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGGGTCCTCCTGGGGACCTCCCTCA
CCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTGACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAGGA
GAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTATCAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGT
GACGCCACCTTGGAAGTCCAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAGGACAGCGAGGCCACCCTGGAAG
TCGTGGTGAAAGGCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCAT
CATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAGATACCCCATCCAC
ACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCG
CCGAGGAGATGGAGGGTGAGGTCTTTTATGCAACATCTCCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTGGC
CACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGCTGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCC
CGGCCCAACTGCGGTGGCAACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCCTCATCCCGCTACGACGCCATCT
GCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAACTTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATGGA
GCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACCGTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCC
GAGGAGCCCTTCACGTTTGCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACCAGGCCCTGGGGCTTTCCCACAC
CTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGACCTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGGGGGTCGTCTTCCA
CTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGCCTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAG
GCCGCCTACGAAGCAGGCTATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAGATACCCCATTGTGAGCCCCCGGACCCCATGCGTGGGTG
ACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTGCGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGGGGGAGGTGTT
CTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCTCACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCC
TGGAGCCGCGGCCTGGACAAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGGCCTGCCTGCGGTGGGGACAAGC
CAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACGGGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAGGCATTTCAGCGGTTCC
TTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGGATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTA
GAAGAGGAGACAACTGCTGTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACAGAATGGGAACCAGCCTATACCC
CAGTGGGCACATCCCCGCTGCCAGGGATCCTTCCTACTTGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTGCC
CTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCCCCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCA
GTGGAGCTGTTCCCCTCAGAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAGCCGTATACACCTTCACCCCCCG
TGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAATCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTTGA
CTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGACTCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTG
GAAAGTGGACTACCCTCAGGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGAGCTGAGATCCTAGAGGGCTCTG
CCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGAGAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAAGT
TCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTT
CCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGG
ACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGC
CCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT
CTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTC
CTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGA
CATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCC
CCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTC
TAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCC
TTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGATGAG
ATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCTACCT
CTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCTGTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGT
TGTAGAGACTTCTGCCTCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCTGGAGTAGAGGACCTCAGCAGGCTC
CCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCTGGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCTGAAG
TAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCTTCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGA
CTTGGTGGGGTCAGCTTCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCAGAAACAAGTGGTCTTCCCTCTGGA
TTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGTGGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCCCTAG
TGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGGAGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACT
GCCCTCCAGTGAGCTGGACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCTGGGTCTCCTGATGTCAGTGGGGAA
ATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCAGGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCTGGAC
AACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTTGGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCT
CAGTGGGCAGCCTTCAGGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACGAGTGGCAGCGGTGAATCTTCTGGG
ATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCCCCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCCGGAG
AGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGAACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAG
TGGCCTACCAAGTGGCATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGAGCATATTATGGCAGTGGAACTCCA
TCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACTTTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGCATTT
TAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGATTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAG
CGGAGAGCCACCAGGTACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTAGCCATGGGCACCAGTGGAGAGGCC
TCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAGTTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTGACAC
ACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGTGGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATC
AGTCCCAGAATCTAGCAGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGCAGAGAAGATTCTGGGTCCCCTGAT
CTGAGTGAAACCACCTCTGCATTCCACGAAGCTAACCTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAGGCGT
CCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAGGCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAG
GACTGAAATCAGCGGAGACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCTGAGTGGACCCAGCAGACCCAGCGC
CCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGCCTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCTTCCA
TCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAGACCAGGAGGTATGTGAGGAGGGCTGGAACAAGTACCAGGGCCACTGTTACCG
CCACTTCC
CGGACCGCGAGACCTGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCGAGGAGCAGGAGTTT
GTCAACAACAATGCCCAAGACTACCAGTGGATCGGCCTGAACGACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCCCATGCAATTTGAGA
ACTGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATCTGGCACGAGAAGGGCGAGTGGAATGATGTTCCCTGCAA
TTACCACCTCCCCTTCACGTGTAAAAAGGGCACAGCCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCACCCTCGGAGGAGCCGCCCCAGC
ACAGCCCACTGAGAAGAGCTTCCAGGACGCACCCAGGACGCTGAGCCCAGGAGCCTGCCAGGCTGACGTGCATCCCACCCAGACGGTGTCCTCTTCTTGT
CGCTTTTTGTCATATAAGGAATCCCATTAAA
  • refseq_AGC1.F3 (forward primer)
  • refseq_AGC1.R3 (reverse primer)
  • Single exon skipping

Frame 0

ARCVGLKFLEKGVQLFKVNYDHFTLGFRDSEGH
HCSCHCRNFRP*QLAECQHPPTVPAEGPPGDLPH
HPLLFHRPHAPCDHRPFYRPTGPKNQVEPCVQG
EGGSAAGGH*RARAGQQCLSGQGLTAQLPGHPQ
*RHLGSPEPALQ*LWGLPLRGDAWHRGQRGHPGS
RGERHRVPLQSHLYTLHPRL*QGAAGLPAEQCH
HCHA*AAAGRLRRRLPPV*RRLAG*PDCQIPHP
HSPGRLLWRQG*VSWCEDVWHPRHQRDL*CVLLR
RGDGG*GLLCNISREVHLPGSSQ*VPAAGCPAG
HHGPALPGLAGWHGHVQRRLAGRPQRALPHLQG
PAQLRWQPPGREDRLRACQPDGLPRPLIPLRRHL
LHR*RLCGHPRKLLWSGG*GGHHRPDSDLA*HG
AATASKHH*G*SPRQRDPYRKAHLRGLPQSPGT
RGALHVCP*NRGHCLR*G*E*DWRGHQALGLSHT
WPGPCHGIHQ*GPRRAGDRCPWAAAFARGGRLP
LPPGTHPLLADL*GGTAGLPAHGGGHCLAGAAP
GRLRSRL*AV*RRLAAGPDRQIPHCEPPDPMRG*
QGQQPRGQDLWRAPINRDLRCLLLCRQT*GGGV
LRHTP*AVHLPGSTGVL*ISQCYAGHHGPALRR
LEPRPGQVLCRLAGRRQPPLPHRHPKACLRWGQA
RRENGLPLP*PDGPPRPTVPAPCLLLPRHFSGS
FSRRRRGWHTHITLWCGGVDRDPSGSWCGCCPR
RRGDNCCTLRGDYCHPRVHHRARKPDRMGTSLYP
SGHIPAARDPSYLASHWRSNRGKYRRPFCN*SA
LCLRGTIPLRGAIPLRGAIPLRGTIPLSEAIPL
SGAVPLRGAIPLQGAIPLRGTISLGRAVYTFTPR
AQLD*AAQLWGGIWGP*CQW*LHRQWRCFRTP*
LQWAAVRGQGKWTALWRPGLQWSYFHSGLRPAC
GKWTTLRG*REN*VAQHSYGW*TALWS*DPRGLC
LWSWGSQWTSFWRSSRDLCLWSRRPQWASFWRS
SRDHCPWSRGHQRASFWRSSRDHCPWSRGHQRA
SFWRSSRDHCPWSRGHQRASFWRSSRDHCPWSRG
HQRASFWRSSRDHCPWSRGHQRASFWRSSRDHC
PWSRGHQRASFWRSSRDRCPWSRGHQRASFWRS
SRDRCPWSRGHQRASFWRSSRDRCPWSRGHQRAS
FWRSSRDRCPWSRGHQRASFWRSSRDRCPWSRG
HQRASFWRSSRDRCPWSRGHQRASFWRSSRDCC
PWSRGHQRASFWRSSRDCCPWSRGHQRASFWRSS
RDCCPWSRGHQRASFWRSSRDCCPWSRGHQRAS
FWRSSRDYCPWSRGDQRASFWRSSRDYCPWSR*
DQWASFWRSSRDYCPWSRGDQRASFWRSSRDFYL
CGRGPQWTSFWRRSSRDFCLWSRGHQWASFWRG
CRDFCLWNRGCQ*TSFRRRSRDLCFWSRGPQQA
PFWRRSSRDFCLWIWGPQWTSFWRRRSRDLCF*S
RD*PQWASFWKGGSRDFSFWS*GPQWVAFWKRR
LGGVSFWRLGLGQTAFWNSRKWASSRNKWSSLW
I*W*VFWGGPWKWPTLWPA*L*WTSIWIPNCFPS
GFYIGGSGHSLHCK*TGREGNHWHQWCRRNIWT
ALQ*AGH*WES*WTPFRN*TQWPSIWVS*CQWG
NTWTLWCQWTAIRVS*H*WGNIWSD*A*RAVLWT
TRY*WRSIWSSLWH*STLWHN*SEWRNIWGP*S
QWAAFRVTRVQWGNIRSP*PGFWYHEWQR*IFW
DYICGHQFG*SGPYYI*RRRRLRVCGTQWPPFRR
GRSVRQIWDGGCQWTVFWNSRFQWVYIPDSGIQ
WPTKWHS*GQWRILQS*DWEQPALGSILWQWNS
I*FPHCLSCRQNFGGICNPGSNSPRGRRRAFWHF
RTQWCSFWSTRHVWGAFWISGPKWAAVRADRAQ
RRATRYSIF*WGFCQHHQCKWRILCSHGHQWRG
LRTSRSYFNHF*VRGGCY*TNYFSGTRPKAPCDT
HTPAF*VQWKSLHSWGH*WSYPSAPWVWSRSII
SPRI*Q*DVRLS*SWVRGICRP*GQQRRFWVP*
SE*NHLCIPRS*P*EILWPRSERQHFDISRRRGV
RCPRSEWRIHHHQ*CGDRGTRLAFSHSHGFWRQ
D*NQRRPVWSHLAAGRCHQHQHPRV*VDPADPA
PCRDASRN*VLKPPVLRRRDSHSRNSHLPNRCFH
PSFSGMET*IRINCCRPGGM*GGLEQVPGPLLP
PLP
GPRDLGGC*APVSGAAVTPEQHRHPRGAGV
CQQQCPRLPVDRPERQDHRRGLPLVRWTPHAI*E
LAPQPA*QLFCRWRGLCGDDLAREGRVE*CSLQ
LPPPLHV*KGHSHHLQTQTTEAELTAPSEEPPQ
HSPLRRASRTHPGR*AQEPARLTCIPPRRCPLLV
AFCHIRNPIK

Frame 1

PGVWD*SSWRRESNSSR*TMTTLLWVFVTLRVI
TAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSL
TIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKE
KEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPS
DATLEVQSLRSNDSGVYRCEVMHGIEDSEATLE
VVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAI
IATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH
TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCF
AEEMEGEVFYATSPEKFTFQEAANECRRLGARLA
TTGQLYLAWQAGMDMCSAGWLADRSVRYPISKA
RPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAI
CYTGEDFVDIPENFFGVGGEEDITVQTVTWPDME
LPLPRNITEGEARGSVILTVKPIFEVSPSPLEP
EEPFTFAPEIGATAFAEVENETGEATRPWGFPT
PGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFH
YRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQ
AAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVG
DKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVF
FATRLEQFTFQEALEFCESHNATLATTGQLYAA
WSRGLDKCYAGWLADGSLRYPIVTPRPACGGDK
PGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVP
SPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPV
EEETTAVPSGETTAILEFTTEPENQTEWEPAYT
PVGTSPLPGILPTWPPTGAATEESTEGPSATEVP
SASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPS
VELFPSEEPFPSKEPSPSEEPSASEEPYTPSPP
VPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLD
FSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPV
ESGLPSGDEERIEWPSTPTVGELPSGAEILEGS
ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEV
LETTAPGVEDISGLPSGEVLETTAPGVEDISGL
PSGEVLETTAPGVEDISGLPSGEVLETTAPGVE
DISGLPSGEVLETTAPGVEDISGLPSGEVLETTA
PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV
LETAAPGVEDISGLPSGEVLETAAPGVEDISGL
PSGEVLETAAPGVEDISGLPSGEVLETAAPGVED
ISGLPSGEVLETAAPGVEDISGLPSGEVLETAA
PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV
LETAAPGVEDISGLPSGEVLETAAPGVEDISGLP
SGEVLETTAPGVEEISGLPSGEVLETTAPGVDE
ISGLPSGEVLETTAPGVEEISGLPSGEVLETST
SAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEV
VETSASGIEDVSELPSGEGLETSASGVEDLSRL
PSGEEVLEISASGFGDLSGLPSGGEGLETSASE
VGTDLSGLPSGREGLETSASGAEDLSGLPSGKED
LVGSASGDLDLGKLPSGTLGSGQAPETSGLPSG
FSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSL
VDSTLVEVVTASTASELEGRGTIGISGAGEISGL
PSSELDISGRASGLPSGTELSGQASGSPDVSGE
IPGLFGVSGQPSGFPDTSGETSGVTELSGLSSG
QPGISGEASGVLYGTSQPFGITDLSGETSGVPDL
SGQPSGLPGFSGATSGVPDLVSGTTSGSGESSG
ITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSG
EADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFS
GLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTP
SSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGI
LELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPS
GEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA
SGLPEVTLITSEFVEGVTEPTISQELGQRPPVT
HTPQLFESSGKVSTAGDISGATPVLPGSGVEVSS
VPESSSETSAYPEAGFGASAAPEASREDSGSPD
LSETTSAFHEANLERSSGLGVSGSTLTFQEGEA
SAAPEVSGESTTTSDVGTEAPGLPSATPTASGDR
TEISGDLSGHTSQLGVVISTSIPESEWTQQTQR
PAETHLEIESSSLLYSGEETHTVETATSPTDAS
IPASPEWKRESESTAADQEVCEEGWNKYQGHCYR
HF
PDRETWVDAERRCREQQSHLSSIVTPEEQEF
VNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFE
NWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCN
YHLPFTCKKGTATTYKRRLQKRSSRHPRRSRPS
TAH*EELPGRTQDAEPRSLPG*RASHPDGVLFL
SLFVI*GIPL

Frame 2

QVCGTEVLGEGSPTLQGEL*PLYSGFS*L*GSS
LQLSL*KLQTMTTR*VSASPNRPR*GSSWGPPS
PSPAISSTPCTL*PPPLLPPHWPQESSGAVCPR
RRR*CCWWPLKGACGSTVPIRTRSHCPTTRPSPV
TPPWKSRACAPMTLGSTAAR*CMASRTARPPWK
SW*KASCSITEPSLHATPSTLTGRSGPACRTVP
SLPRLSSCRPPTKTASTSVTPAGWLTRLSDTPST
LPGKAAMETRMSFLV*GRMASETPTRPMMCTAS
PRRWRVRSFMQHLQRSSPSRKQPMSAGGWVPGW
PPRASSTWPGRLAWTCAAPAGWPTAACATPSPRP
GPTAVATSWA*GPSTCMPTRRATPTPHPATTPS
ATQVKTLWTSQKTSLEWGVRRTSPSRQ*PGLTW
SCHCLETSLRVKPEAA*SLP*SPSSRSPPVPWNP
RSPSRLPLK*GPLPSLRLRMRLERPPGPGAFPH
LAWALPRHSPVRTSSCR*PLSLGSRICQGGSSS
TTARDPPATR*PLRRHSRPACARGRSLPRRSSSR
PPTKQAMSSVTPAGCGTRPSDTPL*APGPHAWV
TRTAAQGSGPMACAHQQRPTMSTAL*TDLRGRC
SSPHALSSSPSRKHWSSVNLTMLRWPPRASSTPP
GAAAWTSAMPAGWPTAASATPSSPQGLPAVGTS
QA*ERSTSTLTRRASQTHCPGTMPSASEAFQRF
LLQEKKRVAHPHHPLVWRSGS*PKWFLVWLLSP*
KRRQLLYPQGRLLPS*SSPPSQKTRQNGNQPIP
QWAHPRCQGSFLLGLPLAQQQRKVQKALLQLKC
PLPQRNHPPQRCHSPQRSHPPQRNHSPQ*GHSPQ
WSCSPQRSHSPPRSHPPQRNHQPRKSRIHLHPP
CPAGLSCPALGRNLGPLMSVVTSQAVEMFQDTL
TSVGSCQGTGQVDCPLETWTPVVLLPQWAQACLW
KVDYPQGMKRELSGPALLRLVNCPLELRS*RAL
PLELGISVDFLLEKF*RPLPLE*ETSVGFLLEK
F*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF
LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R
TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RPL
PLE*RTSAGFLLEKF*RPLPLE*RTSAGFLLEKF
*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF
LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R
TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RLLP
LE*RTSAGFLLEKF*RLLPLE*RTSAGFLLEKF
*RLLPLE*RTSAGFLLEKF*RLLPLE*RTSAGF
LLEKF*RLLPLE*RRSAGFLLEKF*RLLPLE*MR
SVGFLLEKF*RLLPLE*RRSAGFLLEKF*RLLP
LR*GTSVDFLLEEKF*RFLSLE*RTSVGFLLER
L*RLLPLE*RMSVNFLQEKV*RPLLLE*RTSAGS
LLEKKF*RFLPLDLGTSVDFLLEEKV*RPLLLK
*GLTSVGFLLEGRV*RLQLLELRTSVGCLLEKK
TWWGQLLETWTWANCLLEL*EVGKLQKQVVFPLD
LVVSILGWTLEVAHPLACLTLVDFHLDSQLFP*
WILHWWKWSQPPLQVNWKGGEPLASVVQEKYLD
CPPVSWTLVGELVDSLQELNSVAKHLGLLMSVGK
YLDSLVSVDSHQGFLTLVGKHLE*LSLAGCPLD
NQVLVEKHLEFFMALVNPLA*LI*VEKHLGSLI
SVGSLQGYQGSVGQHQESLTWFLVPRVAAVNLLG
LHLWTPVWLKWPLLHLKKKKA*GLWNSVASLPE
RQICQANLGWWMSVDSFLEQSIPVGLHPRLRNS
VAYQVA*LRSVENPPELRLGAACPREHIMAVELH
LVSPLSLL*TELWWNL*PRLQQPKRQEKGLLAF
*NSVVLILEHQTCLGSILDFWT*VGCSPG**SP
AESHQVLHILVGILPAPPM*VENPL*PWAPVERP
QDFQKLL*SLLSSWRVLLNQLFLRN*AKGPL*H
THPSFLSPVEKSPQLGTLVELPQCSLGLE*KYH
QSQNLAVRRPPILKLGSGHLPPLRPAEKILGPLI
*VKPPLHSTKLTLRDPLA*E*AAAL*HFKKARR
PLPQK*VENPPPPVMWGQRHQACLQPLPRLLET
GLKSAETCLVTPRSWALSSAPASQSLSGPSRPSA
LQRRI*KLSPQASCTQEKRLTQSKQPPPQQMLP
SQLLRNGNVNQNQLLQTRRYVRRAGTSTRATVT
ATS
RTARPGWMLSAGVGSSSHT*AASSPPRSRSL
STTMPKTTSGSA*TTGPSKGTSAGQMDTPCNLR
TGAPTSLTTFLPLERTVW**SGTRRASGMMFPA
ITTSPSRVKRAQPPPTNADYRSGAHGTLGGAAPA
QPTEKSFQDAPRTLSPGACQADVHPTQTVSSSC
RFLSYKESH*

Sequence NM_013227

GCCAGGTGTGTGGGACTGAAGTTCTTGGAGAAGGGAGTCCAACTCTTCAAGGTGAACTATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATC
ACTGCAGCTGTCACTGTAGAAACTTCAGACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGGGTCCTCCTGGGGACCTCCCTCA
CCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTGACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAGGA
GAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTATCAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGT
GACGCCACCTTGGAAGTCCAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAGGACAGCGAGGCCACCCTGGAAG
TCGTGGTGAAAGGCATCGTGTTCCATTACAGAGCCATCTCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCCAT
CATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGACGCCGGCTGGCTGGCTGACCAGACTGTCAGATACCCCATCCAC
ACTCCCCGGGAAGGCTGCTATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAGACCTATGATGTGTACTGCTTCG
CCGAGGAGATGGAGGGTGAGGTCTTTTATGCAACATCTCCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTGGC
CACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGCTGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCC
CGGCCCAACTGCGGTGGCAACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCCTCATCCCGCTACGACGCCATCT
GCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAACTTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATGGA
GCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACCGTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCC
GAGGAGCCCTTCACGTTTGCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACCAGGCCCTGGGGCTTTCCCACAC
CTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGACCTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGGGGGTCGTCTTCCA
CTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGCCTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAG
GCCGCCTACGAAGCAGGCTATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAGATACCCCATTGTGAGCCCCCGGACCCCATGCGTGGGTG
ACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTGCGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGGGGGAGGTGTT
CTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCTCACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCC
TGGAGCCGCGGCCTGGACAAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGGCCTGCCTGCGGTGGGGACAAGC
CAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACGGGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAGGCATTTCAGCGGTTCC
TTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGGATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTA
GAAGAGGAGACAACTGCTGTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACAGAATGGGAACCAGCCTATACCC
CAGTGGGCACATCCCCGCTGCCAGGGATCCTTCCTACTTGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTGCC
CTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCCCCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCA
GTGGAGCTGTTCCCCTCAGAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAGCCGTATACACCTTCACCCCCCG
TGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAATCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTTGA
CTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGACTCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTG
GAAAGTGGACTACCCTCAGGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGAGCTGAGATCCTAGAGGGCTCTG
CCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGAGAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAAGT
TCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTT
CCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGG
ACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACTGC
CCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT
CTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTC
CTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGA
CATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCC
CCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTC
TAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCC
TTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGATGAG
ATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCTACCT
CTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCTGTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGT
TGTAGAGACTTCTGCCTCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCTGGAGTAGAGGACCTCAGCAGGCTC
CCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCTGGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCTGAAG
TAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCTTCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGA
CTTGGTGGGGTCAGCTTCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCAGAAACAAGTGGTCTTCCCTCTGGA
TTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGTGGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCCCTAG
TGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGGAGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACT
GCCCTCCAGTGAGCTGGACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCTGGGTCTCCTGATGTCAGTGGGGAA
ATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCAGGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCTGGAC
AACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTTGGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCT
CAGTGGGCAGCCTTCAGGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACGAGTGGCAGCGGTGAATCTTCTGGG
ATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCCCCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCCGGAG
AGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGAACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAG
TGGCCTACCAAGTGGCATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGAGCATATTATGGCAGTGGAACTCCA
TCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACTTTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGCATTT
TAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGATTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAG
CGGAGAGCCACCAGGTACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTAGCCATGGGCACCAGTGGAGAGGCC
TCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAGTTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTGACAC
ACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGTGGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATC
AGTCCCAGAATCTAGCAGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGCAGAGAAGATTCTGGGTCCCCTGAT
CTGAGTGAAACCACCTCTGCATTCCACGAAGCTAACCTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAGGCGT
CCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAGGCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAG
GACTGAAATCAGCGGAGACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCTGAGTGGACCCAGCAGACCCAGCGC
CCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGCCTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCTTCCA
TCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAGCCCCCGCCAGGTCCTGTGCAGAGGAGCCCTGTGGAGCTGGGACCTGCAAGGA
GACAGAGGGACACGTCATATGCCTGTGCCCCCCTGGCTACACTGGCGAGCACTGTAACATAG
ACCAGGAGGTATGTGAGGAGGGCTGGAACAAGTACCAG
GGCCACTGTTACCGCCACTTCCCGGACCGCGAGACCTGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCG
AGGAGCAGGAGTTTGTCAACAACAATGCCCAAGACTACCAGTGGATCGGCCTGAACGACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCC
CATGCAATTTGAGAACTGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATCTGGCACGAGAAGGGCGAGTGGAAT
GATGTTCCCTGCAATTACCACCTCCCCTTCACGTGTAAAAAGGGCACAGTGGCCTGCGGAGAGCCCCCTGTGGTGGAGCATGCCAGGACCTTCGGGCAGA
AGAAGGACCGGTATGAGATCAATTCCCTGGTGCGGTACCAGTGCACAGAGGGGTTTGTCCAGCGCCACATGCCCACCATCCGGTGCCAGCCCAGCGGGCA
CTGGGAGGAGCCTCAGATCACCTGCACAGACCCCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCACCCTCGGAGGAGCCGCCCCAGCACA
GCCCACTGAGAAGAGCTTCCAGGACGCACCCAGGACGCTGAGCCCAGGAGCCTGCCAGGCTGACGTGCATCCCACCCAGACGGTGTCCTCTTCTTGTCGC
TTTTTGTCATATAAGGAATCCCATTAAA
  • refseq_AGC1.F3 (forward primer)
  • refseq_AGC1.R3 (reverse primer)
  • Single exon skipping

Frame 0

ARCVGLKFLEKGVQLFKVNYDHFTLGFRDSEGH
HCSCHCRNFRP*QLAECQHPPTVPAEGPPGDLPH
HPLLFHRPHAPCDHRPFYRPTGPKNQVEPCVQG
EGGSAAGGH*RARAGQQCLSGQGLTAQLPGHPQ
*RHLGSPEPALQ*LWGLPLRGDAWHRGQRGHPGS
RGERHRVPLQSHLYTLHPRL*QGAAGLPAEQCH
HCHA*AAAGRLRRRLPPV*RRLAG*PDCQIPHP
HSPGRLLWRQG*VSWCEDVWHPRHQRDL*CVLLR
RGDGG*GLLCNISREVHLPGSSQ*VPAAGCPAG
HHGPALPGLAGWHGHVQRRLAGRPQRALPHLQG
PAQLRWQPPGREDRLRACQPDGLPRPLIPLRRHL
LHR*RLCGHPRKLLWSGG*GGHHRPDSDLA*HG
AATASKHH*G*SPRQRDPYRKAHLRGLPQSPGT
RGALHVCP*NRGHCLR*G*E*DWRGHQALGLSHT
WPGPCHGIHQ*GPRRAGDRCPWAAAFARGGRLP
LPPGTHPLLADL*GGTAGLPAHGGGHCLAGAAP
GRLRSRL*AV*RRLAAGPDRQIPHCEPPDPMRG*
QGQQPRGQDLWRAPINRDLRCLLLCRQT*GGGV
LRHTP*AVHLPGSTGVL*ISQCYAGHHGPALRR
LEPRPGQVLCRLAGRRQPPLPHRHPKACLRWGQA
RRENGLPLP*PDGPPRPTVPAPCLLLPRHFSGS
FSRRRRGWHTHITLWCGGVDRDPSGSWCGCCPR
RRGDNCCTLRGDYCHPRVHHRARKPDRMGTSLYP
SGHIPAARDPSYLASHWRSNRGKYRRPFCN*SA
LCLRGTIPLRGAIPLRGAIPLRGTIPLSEAIPL
SGAVPLRGAIPLQGAIPLRGTISLGRAVYTFTPR
AQLD*AAQLWGGIWGP*CQW*LHRQWRCFRTP*
LQWAAVRGQGKWTALWRPGLQWSYFHSGLRPAC
GKWTTLRG*REN*VAQHSYGW*TALWS*DPRGLC
LWSWGSQWTSFWRSSRDLCLWSRRPQWASFWRS
SRDHCPWSRGHQRASFWRSSRDHCPWSRGHQRA
SFWRSSRDHCPWSRGHQRASFWRSSRDHCPWSRG
HQRASFWRSSRDHCPWSRGHQRASFWRSSRDHC
PWSRGHQRASFWRSSRDRCPWSRGHQRASFWRS
SRDRCPWSRGHQRASFWRSSRDRCPWSRGHQRAS
FWRSSRDRCPWSRGHQRASFWRSSRDRCPWSRG
HQRASFWRSSRDRCPWSRGHQRASFWRSSRDCC
PWSRGHQRASFWRSSRDCCPWSRGHQRASFWRSS
RDCCPWSRGHQRASFWRSSRDCCPWSRGHQRAS
FWRSSRDYCPWSRGDQRASFWRSSRDYCPWSR*
DQWASFWRSSRDYCPWSRGDQRASFWRSSRDFYL
CGRGPQWTSFWRRSSRDFCLWSRGHQWASFWRG
CRDFCLWNRGCQ*TSFRRRSRDLCFWSRGPQQA
PFWRRSSRDFCLWIWGPQWTSFWRRRSRDLCF*S
RD*PQWASFWKGGSRDFSFWS*GPQWVAFWKRR
LGGVSFWRLGLGQTAFWNSRKWASSRNKWSSLW
I*W*VFWGGPWKWPTLWPA*L*WTSIWIPNCFPS
GFYIGGSGHSLHCK*TGREGNHWHQWCRRNIWT
ALQ*AGH*WES*WTPFRN*TQWPSIWVS*CQWG
NTWTLWCQWTAIRVS*H*WGNIWSD*A*RAVLWT
TRY*WRSIWSSLWH*STLWHN*SEWRNIWGP*S
QWAAFRVTRVQWGNIRSP*PGFWYHEWQR*IFW
DYICGHQFG*SGPYYI*RRRRLRVCGTQWPPFRR
GRSVRQIWDGGCQWTVFWNSRFQWVYIPDSGIQ
WPTKWHS*GQWRILQS*DWEQPALGSILWQWNS
I*FPHCLSCRQNFGGICNPGSNSPRGRRRAFWHF
RTQWCSFWSTRHVWGAFWISGPKWAAVRADRAQ
RRATRYSIF*WGFCQHHQCKWRILCSHGHQWRG
LRTSRSYFNHF*VRGGCY*TNYFSGTRPKAPCDT
HTPAF*VQWKSLHSWGH*WSYPSAPWVWSRSII
SPRI*Q*DVRLS*SWVRGICRP*GQQRRFWVP*
SE*NHLCIPRS*P*EILWPRSERQHFDISRRRGV
RCPRSEWRIHHHQ*CGDRGTRLAFSHSHGFWRQ
D*NQRRPVWSHLAAGRCHQHQHPRV*VDPADPA
PCRDASRN*VLKPPVLRRRDSHSRNSHLPNRCFH
PSFSGMET*IRINCCSPRQVLCRGALWSWDLQG
DRGTRHMPVPPWLHWRAL*HR
PGGM*GGLEQVP
GPLLPPLPGPRDLGGC*APVSGAAVTPEQHRHPR
GAGVCQQQCPRLPVDRPERQDHRRGLPLVRWTP
HAI*ELAPQPA*QLFCRWRGLCGDDLAREGRVE
*CSLQLPPPLHV*KGHSGLRRAPCGGACQDLRAE
EGPV*DQFPGAVPVHRGVCPAPHAHHPVPAQRA
LGGASDHLHRPHHLQTQTTEAELTAPSEEPPQH
SPLRRASRTHPGR*AQEPARLTCIPPRRCPLLVA
FCHIRNPIK

Frame 1

PGVWD*SSWRRESNSSR*TMTTLLWVFVTLRVI
TAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSL
TIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKE
KEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPS
DATLEVQSLRSNDSGVYRCEVMHGIEDSEATLE
VVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAI
IATPEQLQAAYEDGFHQCDAGWLADQTVRYPIH
TPREGCYGDKDEFPGVRTYGIRDTNETYDVYCF
AEEMEGEVFYATSPEKFTFQEAANECRRLGARLA
TTGQLYLAWQAGMDMCSAGWLADRSVRYPISKA
RPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAI
CYTGEDFVDIPENFFGVGGEEDITVQTVTWPDME
LPLPRNITEGEARGSVILTVKPIFEVSPSPLEP
EEPFTFAPEIGATAFAEVENETGEATRPWGFPT
PGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFH
YRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQ
AAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVG
DKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVF
FATRLEQFTFQEALEFCESHNATLATTGQLYAA
WSRGLDKCYAGWLADGSLRYPIVTPRPACGGDK
PGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVP
SPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPV
EEETTAVPSGETTAILEFTTEPENQTEWEPAYT
PVGTSPLPGILPTWPPTGAATEESTEGPSATEVP
SASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPS
VELFPSEEPFPSKEPSPSEEPSASEEPYTPSPP
VPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLD
FSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPV
ESGLPSGDEERIEWPSTPTVGELPSGAEILEGS
ASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEV
LETTAPGVEDISGLPSGEVLETTAPGVEDISGL
PSGEVLETTAPGVEDISGLPSGEVLETTAPGVE
DISGLPSGEVLETTAPGVEDISGLPSGEVLETTA
PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV
LETAAPGVEDISGLPSGEVLETAAPGVEDISGL
PSGEVLETAAPGVEDISGLPSGEVLETAAPGVED
ISGLPSGEVLETAAPGVEDISGLPSGEVLETAA
PGVEDISGLPSGEVLETAAPGVEDISGLPSGEV
LETAAPGVEDISGLPSGEVLETAAPGVEDISGLP
SGEVLETTAPGVEEISGLPSGEVLETTAPGVDE
ISGLPSGEVLETTAPGVEEISGLPSGEVLETST
SAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEV
VETSASGIEDVSELPSGEGLETSASGVEDLSRL
PSGEEVLEISASGFGDLSGLPSGGEGLETSASE
VGTDLSGLPSGREGLETSASGAEDLSGLPSGKED
LVGSASGDLDLGKLPSGTLGSGQAPETSGLPSG
FSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSL
VDSTLVEVVTASTASELEGRGTIGISGAGEISGL
PSSELDISGRASGLPSGTELSGQASGSPDVSGE
IPGLFGVSGQPSGFPDTSGETSGVTELSGLSSG
QPGISGEASGVLYGTSQPFGITDLSGETSGVPDL
SGQPSGLPGFSGATSGVPDLVSGTTSGSGESSG
ITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSG
EADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFS
GLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTP
SSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGI
LELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPS
GEPPGTPYFSGDFASTTNVSGESSVAMGTSGEA
SGLPEVTLITSEFVEGVTEPTISQELGQRPPVT
HTPQLFESSGKVSTAGDISGATPVLPGSGVEVSS
VPESSSETSAYPEAGFGASAAPEASREDSGSPD
LSETTSAFHEANLERSSGLGVSGSTLTFQEGEA
SAAPEVSGESTTTSDVGTEAPGLPSATPTASGDR
TEISGDLSGHTSQLGVVISTSIPESEWTQQTQR
PAETHLEIESSSLLYSGEETHTVETATSPTDAS
IPASPEWKRESESTAAAPARSCAEEPCGAGTCKE
TEGHVICLCPPGYTGEHCNI
DQEVCEEGWNKYQ
GHCYRHFPDRETWVDAERRCREQQSHLSSIVTP
EEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHP
MQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWN
DVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQ
KKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGH
WEEPQITCTDPTTYKRRLQKRSSRHPRRSRPST
AH*EELPGRTQDAEPRSLPG*RASHPDGVLFLS
LFVI*GIPL

Frame 2

QVCGTEVLGEGSPTLQGEL*PLYSGFS*L*GSS
LQLSL*KLQTMTTR*VSASPNRPR*GSSWGPPS
PSPAISSTPCTL*PPPLLPPHWPQESSGAVCPR
RRR*CCWWPLKGACGSTVPIRTRSHCPTTRPSPV
TPPWKSRACAPMTLGSTAAR*CMASRTARPPWK
SW*KASCSITEPSLHATPSTLTGRSGPACRTVP
SLPRLSSCRPPTKTASTSVTPAGWLTRLSDTPST
LPGKAAMETRMSFLV*GRMASETPTRPMMCTAS
PRRWRVRSFMQHLQRSSPSRKQPMSAGGWVPGW
PPRASSTWPGRLAWTCAAPAGWPTAACATPSPRP
GPTAVATSWA*GPSTCMPTRRATPTPHPATTPS
ATQVKTLWTSQKTSLEWGVRRTSPSRQ*PGLTW
SCHCLETSLRVKPEAA*SLP*SPSSRSPPVPWNP
RSPSRLPLK*GPLPSLRLRMRLERPPGPGAFPH
LAWALPRHSPVRTSSCR*PLSLGSRICQGGSSS
TTARDPPATR*PLRRHSRPACARGRSLPRRSSSR
PPTKQAMSSVTPAGCGTRPSDTPL*APGPHAWV
TRTAAQGSGPMACAHQQRPTMSTAL*TDLRGRC
SSPHALSSSPSRKHWSSVNLTMLRWPPRASSTPP
GAAAWTSAMPAGWPTAASATPSSPQGLPAVGTS
QA*ERSTSTLTRRASQTHCPGTMPSASEAFQRF
LLQEKKRVAHPHHPLVWRSGS*PKWFLVWLLSP*
KRRQLLYPQGRLLPS*SSPPSQKTRQNGNQPIP
QWAHPRCQGSFLLGLPLAQQQRKVQKALLQLKC
PLPQRNHPPQRCHSPQRSHPPQRNHSPQ*GHSPQ
WSCSPQRSHSPPRSHPPQRNHQPRKSRIHLHPP
CPAGLSCPALGRNLGPLMSVVTSQAVEMFQDTL
TSVGSCQGTGQVDCPLETWTPVVLLPQWAQACLW
KVDYPQGMKRELSGPALLRLVNCPLELRS*RAL
PLELGISVDFLLEKF*RPLPLE*ETSVGFLLEK
F*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF
LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R
TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RPL
PLE*RTSAGFLLEKF*RPLPLE*RTSAGFLLEKF
*RPLPLE*RTSAGFLLEKF*RPLPLE*RTSAGF
LLEKF*RPLPLE*RTSAGFLLEKF*RPLPLE*R
TSAGFLLEKF*RPLPLE*RTSAGFLLEKF*RLLP
LE*RTSAGFLLEKF*RLLPLE*RTSAGFLLEKF
*RLLPLE*RTSAGFLLEKF*RLLPLE*RTSAGF
LLEKF*RLLPLE*RRSAGFLLEKF*RLLPLE*MR
SVGFLLEKF*RLLPLE*RRSAGFLLEKF*RLLP
LR*GTSVDFLLEEKF*RFLSLE*RTSVGFLLER
L*RLLPLE*RMSVNFLQEKV*RPLLLE*RTSAGS
LLEKKF*RFLPLDLGTSVDFLLEEKV*RPLLLK
*GLTSVGFLLEGRV*RLQLLELRTSVGCLLEKK
TWWGQLLETWTWANCLLEL*EVGKLQKQVVFPLD
LVVSILGWTLEVAHPLACLTLVDFHLDSQLFP*
WILHWWKWSQPPLQVNWKGGEPLASVVQEKYLD
CPPVSWTLVGELVDSLQELNSVAKHLGLLMSVGK
YLDSLVSVDSHQGFLTLVGKHLE*LSLAGCPLD
NQVLVEKHLEFFMALVNPLA*LI*VEKHLGSLI
SVGSLQGYQGSVGQHQESLTWFLVPRVAAVNLLG
LHLWTPVWLKWPLLHLKKKKA*GLWNSVASLPE
RQICQANLGWWMSVDSFLEQSIPVGLHPRLRNS
VAYQVA*LRSVENPPELRLGAACPREHIMAVELH
LVSPLSLL*TELWWNL*PRLQQPKRQEKGLLAF
*NSVVLILEHQTCLGSILDFWT*VGCSPG**SP
AESHQVLHILVGILPAPPM*VENPL*PWAPVERP
QDFQKLL*SLLSSWRVLLNQLFLRN*AKGPL*H
THPSFLSPVEKSPQLGTLVELPQCSLGLE*KYH
QSQNLAVRRPPILKLGSGHLPPLRPAEKILGPLI
*VKPPLHSTKLTLRDPLA*E*AAAL*HFKKARR
PLPQK*VENPPPPVMWGQRHQACLQPLPRLLET
GLKSAETCLVTPRSWALSSAPASQSLSGPSRPSA
LQRRI*KLSPQASCTQEKRLTQSKQPPPQQMLP
SQLLRNGNVNQNQLLQPPPGPVQRSPVELGPAR
RQRDTSYACAPLATLASTVT*
TRRYVRRAGTSTR
ATVTATSRTARPGWMLSAGVGSSSHT*AASSPP
RSRSLSTTMPKTTSGSA*TTGPSKGTSAGQMDT
PCNLRTGAPTSLTTFLPLERTVW**SGTRRASGM
MFPAITTSPSRVKRAQWPAESPLWWSMPGPSGR
RRTGMRSIPWCGTSAQRGLSSATCPPSGASPAG
TGRSLRSPAQTPPPTNADYRSGAHGTLGGAAPAQ
PTEKSFQDAPRTLSPGACQADVHPTQTVSSSCR
FLSYKESH*

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