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Sequences

Sequence NM_020983

CGGACGGCGGACGGCGGGCGGGACGGCCAGGACGCGCGGGCTCGGAGGACCGCGGGACGGCCGGCCGGCCGGCCGGAGCCCGCGGGGGCGGCGGGGCGGG
GGCCCAGGGCAGGCGCGGAGCCGGGCCGGCAGCAACATGTCATGGTTTAGTGGCCTCCTGGTCCCTAAAGTGGATGAACGGAAAACAGCCTGGGGTGAAC
GCAATGGGCAGAAGCGTTCGCGGCGCCGTGGCACTCGGGCAGGTGGCTTCTGCACGCCCCGCTATATGAGCTGCCTCCGGGATGCAGAGCCACCCAGCCC
CACCCCTGCGGGCCCCCCTCGGTGCCCCTGGCAGGATGACGCCTTCATCCGGAGGGGCGGCCCAGGCAAGGGCAAGGAGCTGGGGCTGCGGGCAGTGGCC
CTGGGCTTCGAGGATACCGAGGTGACAACGACAGCGGGCGGGACGGCTGAGGTGGCGCCCGACGCGGTGCCCAGGAGTGGGCGATCCTGCTGGCGCCGTC
TGGTGCAGGTGTTCCAGTCGAAGCAGTTCCGTTCGGCCAAGCTGGAGCGCCTGTACCAGCGGTACTTCTTCCAGATGAACCAGAGCAGCCTGACGCTGCT
GATGGCGGTGCTGGTGCTGCTCACAGCGGTGCTGCTGGCTTTCCACGCCGCACCCGCCCGCCCTCAGCCTGCCTATGTGGCACTGTTGGCCTGTGCCGCC
GCCCTGTTCGTGGGGCTCATGGTGGTGTGTAACCGGCATAGCTTCCGCCAGGACTCCATGTGGGTGGTGAGCTACGTGGTGCTGGGCATCCTGGCGGCAG
TGCAGGTCGGGGGCGCTCTCGCAGCAGACCCGCGCAGCCCCTCTGCGGGCCTCTGGTGCCCTGTGTTCTTTGTCTACATCGCCTACACGCTCCTCCCCAT
CCGCATGCGGGCTGCCGTCCTCAGCGGCCTGGGCCTCTCCACCTTGCATTTGATCTTGGCCTGGCAACTTAACCGTGGTGATGCCTTCCTCTGGAAGCAG
CTCGGTGCCAATGTGCTGCTGTTCCTCTGCACCAACGTCATTGGCATCTGCACACACTATCCAGCAGAGGTGTCTCAGCGCCAGGCCTTTCAGGAGACCC
GCGGTTACATCCAGGCCCGGCTCCACCTGCAGCATGAGAATCGGCAGCAGGAGCGGCTGCTGCTGTCGGTATTGCCCCAGCACGTTGCCATGGAGATGAA
AGAAGACATCAACACAAAAAAAGAAGACATGATGTTCCACAAGATCTACATACAGAAGCATGACAATGTCAGCATCCTGTTTGCAGACATTGAGGGCTTC
ACCAGCCTGGCATCCCAGTGCACTGCGCAGGAGCTGGTCATGACCCTGAATGAGCTCTTTGCCCGGTTTGACAAGCTGGCTGCGGAGAATCACTGCCTGA
GGATCAAGATCTTGGGGGACTGTTACTACTGTGTGTCAGGGCTGCCGGAGGCCCGGGCCGACCATGCCCACTGCTGTGTGGAGATGGGGGTAGACATGAT
TGAGGCCATCTCGCTGGTACGTGAGGTGACAGGTGTGAATGTGAACATGCGCGTGGGCATCCACAGCGGGCGCGTGCACTGCGGCGTCCTTGGCTTGCGG
AAATGGCAGTTCGATGTGTGGTCCAATGATGTGACCCTGGCCAACCACATGGAGGCAGGAGGCCGGGCTGGCCGCATCCACATCACTCGGGCAACACTGC
AGTACCTGAACGGGGACTACGAGGTGGAGCCAGGCCGTGGTGGCGAGCGCAACGCGTACCTCAAGGAGCAGCACATTGAGACTTTCCTCATCCTGGGCGC
CAGCCAGAAACGGAAAGAGGAGAAGGCCATGCTGGCCAAGCTGCAGCGGACTCGGGCCAACTCCATGGAAGGGCTGATGCCGCGCTGGGTTCCTGATCGT
GCCTTCTCCCGGACCAAGGACTCCAAGGCCTTCCGCCAGATGGGCATTGATGATTCCAGCAAAGACAACCGGGGCACCCAAGATGCCCTGAACCCTGAGG
ATGAGGTGGATGAGTTCCTGAGCCGTGCCATCGATGCCCGCAGCATTGATCAGCTGCGGAAGGACCATGTGCGCCGGTTTCTGCTCACCTTCCAGAGAGA
GGATCTTGAGAAGAAGTACTCCCGGAAGGTGGATCCCCGCTTCGGAGCCTACGTTGCCTGTGCCCTGTTGGTCTTCTGCTTCATCTGCTTCATCCAGCTT
CTCATCTTCCCACACTCCACCCTGATGCTTGGGATCTATGCCAGCATCTTCCTGCTGCTGCTAATCACCGTGCTGATCTGTGCTGTGTACTCCTGTGGTT
CTCTGTTCCCTAAGGCCCTGCAACGTCTGTCCCGCAGCATTGTCCGCTCACGGGCACATAGCACCGCAGTTGGCATCTTTTCCGTCCTGCTTGTGTTTAC
TTCTGCCATTGCCAACATGTACTTCATCGGGAACATGCTGCTGAGTCTCTTGGCCAGCTCTGTCTTCCTGCACATCAGCAGCATCGGGAAGTTGGCCATG
ATCTTTGTCTTGGGGCTCATCTATTTGGTGCTGCTTCTGCTGGGTCCCCCAGCCACCATCTTTGACAACTATGACCTACTGCTTGGCGTCCATGGCTTGG
CTTCTTCCAATGAGACCTTTGATGGGCTGGACTGTCCAGCTGCAGGGAGGGTGGCCCTCAAATATATGACCCCTGTGATTCTGCTGGTGTTTGCGCTGGC
GCTGTATCTGCATGCTCAGCAGGTGGAGTCGACTGCCCGCCTAGACTTCCTCTGGAAACTACAGGCAACAGGGGAGAAGGAGGAGATGGAGGAGCTACAG
GCATACAACCGGAGGCTGCTGCATAACATTCTGCCCAAGGACGTGGCGGCCCACTTCCTGGCCCGGGAGCGCCGCAATGATGAACTCTACTATCAGTCGT
GTGAGTGTGTGGCTGTTATGTTTGCCTCCATTGCCAACTTCTCTGAGTTCTATGTGGAGCTGGAGGCAAACAATGAGGGTGTCGAGTGCCTGCGGCTGCT
CAACGAGATCATCGCTGACTTTGATGAGATTATCAGCGAGGAGCGGTTCCGGCAGCTGGAAAAGATCAAGACGATTGGTAGCACCTACATGGCTGCCTCA
GGGCTGAACGCCAGCACCTACGATCAGGTGGGCCGCTCCCACATCACTGCCCTGGCTGACTACGCCATGCGGCTCATGGAGCAGATGAAGCACATCAATG
AGCACTCCTTCAACAATTTCCAGATGAAGATTGGGCTGAACATGGGCCCAGTCGTGGCAGGTGTCATCGGGGCTCGGAAGCCACAGTATGACATCTGGGG
GAACACAGTGAATGTCTCTAGTCGTATGGACAGCACGGGGGTCCCCGACCGAATCCAGGTGACCACGGACCTGTACCAGGTTCTAGCTGCCAAGGGCTAC
CAGCTGGAGTGTCGAGGGGTGGTCAAGGTGAAGGGCAAGGGGGAGATGACCACCTACTTCCTCAATGGGGGCCCCAGCAGTTAACAGGGCCCAGCCACAA
ATTCAGCTGAAGGGACCAAGGTGGGCATTGAGTGGACTCTGTGCTCACTGGGTGGAGCTGTGGCAGGGGGCACTGAGCCTCCAGACCCTGCTAACCACAA
AAGGGAACATCCCAGCAGGCTGTGCTTGGATCATGCTCGTCTGCCCTCAAGCTGGAAAACAAGGGGCTACCTACCGAGAGGATTATGCAAGTGACTTTCT
TTCTTACTTGGGGTAGGGCTGTTCCCTCTCCAATCTTCCAGCCTTTGGGAGCAGGGGAGGGGTCAGTAGCAGAAGCAGAGGGAGGCCTCTTGCCTGAGGG
ATTAAAATGGCAGCTTGCCATGCCTACCCTTCCCTGTCTGTCTGGGCAGCAGGTTCAGGGCTGAGCCCTTCTTTTCCCTCTTTTTTCCTGGGAATATTTT
GTACAATATTTTGTACAAAGACAGGCATGAGGAGTGCCTATTCCATGCTTGCCTTTGCAATACCTGCATCCCCAGCACTGGTCCTGGGCACTTCCCCACC
CCAGCCAGGTGTCCCTCCTATGCACAGAGCAGAGGAGGGAGAAGCTCTGGGGAGCCAGCTTTGGCCATATTTCAGGAGAATGTTTCCATGTGCCAAATCT
TAGTCCCATGATCTGTCCCCAAAGGGGAACAAAGGGACCTCTGACAGCTTAGATTTAGCCCCAGTTCCTGCACGCTCCAGGGAACGGGGTGTCTGGCCTC
ACTGGTACTGTGAAAAATGCTCAGAGAGCAAGCCTGTGTGTGGGGATGTCAGGTCAGGAGCTGGAAGTTCACCTGCAGGTGCCAAAGAGCAGGCCGGCCA
GGGCTGGGGCAGTGCCAGACTCTGATCTGAGGACCCCGTCGGGGTCCAGATCAGGTCACTCTGCCCCAGTGCTCTCTTGCTGTCTGCTGACAAGGGGGCA
TGGAGCATCTCTTCCTCTTCTGTTGCCAAATAGAAAAGGGTCAGGGCATGGAGAAAGGTGACCCTGATCCCAAACCTGCCCTCCCAAGTCTCTGGTGTTG
GGGAGGGCCCGTGTGTTTGTGTAACTGTGTGTGCATGTTGGTCTTTGTGTGCATATCTGTTTTCCAGGTCTATGTGAGTCCTTGTGCTCCTGCTCCTCAG
CTCTCCACCCCAGGTTGCCTCTCTCCTGTGGGCCTCTGTCTTCTGGGAATAAAGCAGGGTTTCCTACTTCAGGGGATGTAGAGAGATGCCCAGGTTGCAC
AGGAGTGGGATGGGGTGTGGTAGCAAAAGGAGGGAGAGGAGTCCTTTTTGTGCCAAATCCCTAAGTGCCGTTCGGGGGCCATGTGTGCAGCATGACTCTC
CCTGTCTGTGGCAGGGACCCAAGCGCTTGCTTAAGCCCCAGTGCTCCATGCCAGCACTTGAACTGTCTGGGGTTTGATGGACAGAGGCTGAGGAATTTCC
TGGCTTCCCCAGATAGTGTCCTGGGACATGGTATGCTTTGGGGCTGGGGTAGCATGGAATCCCTCTGAGGACCTGGATACTGGTACTACGGGGTGGGGAA
GAGGAACCTTAAACTTGGCTTTCCCCAGCCTTCAGCCTGAGTCTAGCATGTTTCTAGCTCCCCAGTCCCTTGTGAAGCCTTGAGGGCTGGCAGAAGGGTT
AGGAGGTTGAACTCTAGATTCCCTTCCTGTCTTTGCCTTCCTTTTACCCCTTTCCCTGCAACCTCCTTGACTCTGGCCTGAATTTGTTGGTGCCTCAGTT
TCTCTGTCTGTACCTATTTAAGCCAAAGGCACTAGCCTGAATTTTGCTTGAAGATCACTTTGTCTTGGAAATGACTAGAGAGGCAGAGGAGAAGGGTTTC
CAGAGTTGCTAGGTTTGGGAGTGGAAGGGGCAGGCAGTGCACTTGCCCCTCCTCATGCCCCTTCTGACACCAGCTCCCTGTGGAGGCCTGGTTTCTGGGT
AATGCCTCCCTTGGGCATCTTCATGCATCAACCAAATGGGCCATCAGGTACTTCATTAGTCATGGCAGAAGGAGGGGAAAAGACTTGTTTTCCAGACAGA
AAATCTACTCCCCTGTCCCCAGCCATATCCCTGGATAGGAAGGGATAGGAAGAGACTACTTGGTGCCATGGGGTAGGGGTGAGGGTATAAGTAGATCAGA
GTGGGAAGACCTCAGCCTTGGGTGGCTTGTCTCTGCTTCTTGCCAGGTGGGAGGGCCTGTCCACACCCTGGATCCCCGTACCACAGTGCCAGCCATGCCC
TTCCCCTGGGCTACCATTGTCCCTTTCCTCACCCAGTTGGTAGAGGAGTCAGGAGGTGGGAGGCCGTGGGCTTTGGTTTTATAATGTAACCACTGTGGGG
GTGGGGGAGGATGGTGAACCATGTATTTCAGTGAAATATTTAATATATTTAAATATCAATAAAATCAAACTCTTTGT
  • refseq_ADCY6.F1 (forward primer)
  • refseq_ADCY6.R1 (reverse primer)
  • Single exon skipping

Frame 0

RTADGGRDGQDARARRTAGRPAGRPEPAGAAGR
GPRAGAEPGRQQHVMV*WPPGP*SG*TENSLG*T
QWAEAFAAPWHSGRWLLHAPLYELPPGCRATQP
HPCGPPSVPLAG*RLHPEGRPRQGQGAGAAGSG
PGLRGYRGDNDSGRDG*GGARRGAQEWAILLAPS
GAGVPVEAVPFGQAGAPVPAVLLPDEPEQPDAA
DGGAGAAHSGAAGFPRRTRPPSACLCGTVGLCR
RPVRGAHGGV*PA*LPPGLHVGGELRGAGHPGGS
AGRGRSRSRPAQPLCGPLVPCVLCLHRLHAPPH
PHAGCRPQRPGPLHLAFDLGLAT*PW*CLPLEA
ARCQCAAVPLHQRHWHLHTLSSRGVSAPGLSGDP
RLHPGPAPPAA*ESAAGAAAAVGIAPARCHGDE
RRHQHKKRRHDVPQDLHTEA*QCQHPVCRH*GL
HQPGIPVHCAGAGHDPE*ALCPV*QAGCGESLPE
DQDLGGLLLLCVRAAGGPGRPCPLLCGDGGRHD
*GHLAGT*GDRCECEHARGHPQRARALRRPWLA
EMAVRCVVQ*CDPGQPHGGRRPGWPHPHHSGNTA
VPERGLRGGARPWWRAQRVPQGAAH*DFPHPGR
QPETERGEGHAGQAAADSGQLHGRADAALGS*S
CLLPDQGLQGLPPDGH**FQQRQPGHPRCPEP*G
*GG*VPEPCHRCPQH*SAAEGPCAPVSAHLPER
GS*EEVLPEGGSPLRSLRCLCPVGLLLHLLHPA
SHLPTLHPDAWDLCQHLPAAANHRADLCCVLLWF
SVP*GPATSVPQHCPLTGT*HRSWHLFRPACVY
FCHCQHVLHREHAAESLGQLCLPAHQQHREVGH
DLCLGAHLFGAASAGSPSHHL*QL*PTAWRPWLG
FFQ*DL*WAGLSSCREGGPQIYDPCDSAGVCAG
AVSACSAGGVDCPPRLPLETTGNRGEGGDGGAT
GIQPEAAA*HSAQGRGGPLPGPGAPQ**TLLSVV
*VCGCYVCLHCQLL*VLCGAGGKQ*GCRVPAAA
QRDHR*L**DYQRGAVPAAGKDQDDW*HLHGCL
RAERQHLRSGGPLPHHCPG*LRHAAHGADEAHQ*
ALLQQFPDEDWAEHGPSRGRCHRGSEATV*HLG
EHSECL*SYGQHGGPRPNPGDHGPVPGSSCQGL
PAGVSRGGQGEGQGGDDHLLPQWGPQQLTGPSHK
FS*RDQGGH*VDSVLTGWSCGRGH*ASRPC*PQ
KGTSQQAVLGSCSSALKLENKGLPTERIMQVTF
FLTWGRAVPSPIFQPLGAGEGSVAEAEGGLLPEG
LKWQLAMPTLPCLSGQQVQG*ALLFPLFSWEYF
VQYFVQRQA*GVPIPCLPLQYLHPQHWSWALPH
PSQVSLLCTEQRREKLWGASFGHISGECFHVPNL
SPMICPQRGTKGPLTA*I*PQFLHAPGNGVSGL
TGTVKNAQRASLCVGMSGQELEVHLQVPKSRPA
RAGAVPDSDLRTPSGSRSGHSAPVLSCCLLTRGH
GASLPLLLPNRKGSGHGER*P*SQTCPPKSLVL
GRARVFV*LCVHVGLCVHICFPGLCESLCSCSS
ALHPRLPLSCGPLSSGNKAGFPTSGDVERCPGCT
GVGWGVVAKGGRGVLFVPNP*VPFGGHVCSMTL
PVCGRDPSACLSPSAPCQHLNCLGFDGQRLRNF
LASPDSVLGHGMLWGWGSMESL*GPGYWYYGVGK
RNLKLGFPQPSA*V*HVSSSPVPCEALRAGRRV
RRLNSRFPSCLCLPFTPFPATSLTLA*ICWCLS
FSVCTYLSQRH*PEFCLKITLSWK*LERQRRRVS
RVARFGSGRGRQCTCPSSCPF*HQLPVEAWFLG
NASLGHLHASTKWAIRYFISHGRRRGKDLFSRQ
KIYSPVPSHIPG*EGIGRDYLVPWGRGEGISRSE
WEDLSLGWLVSASCQVGGPVHTLDPRTTVPAMP
FPWATIVPFLTQLVEESGGGRPWALVL*CNHCG
GGGGW*TMYFSEIFNIFKYQ*NQTLC

Frame 1

GRRTAGGTARTRGLGGPRDGRPAGRSPRGRRGG
GPGQARSRAGSNMSWFSGLLVPKVDERKTAWGE
RNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSP
TPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVA
LGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRR
LVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLL
MAVLVLLTAVLLAFHAAPARPQPAYVALLACAA
ALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAA
VQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPI
RMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQ
LGANVLLFLCTNVIGICTHYPAEVSQRQAFQET
RGYIQARLHLQHENRQQERLLLSVLPQHVAMEMK
EDINTKKEDMMFHKIYIQKHDNVSILFADIEGF
TSLASQCTAQELVMTLNELFARFDKLAAENHCL
RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMI
EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR
KWQFDVWSNDVTLANHMEAGGRAGRIHITRATL
QYLNGDYEVEPGRGGERNAYLKEQHIETFLILGA
SQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDR
AFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPE
DEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQRE
DLEKKYSRKVDPRFGAYVACALLVFCFICFIQL
LIFPHSTLMLGIYASIFLLLLITVLICAVYSCG
SLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFT
SAIANMYFIGNMLLSLLASSVFLHISSIGKLAM
IFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGL
ASSNETFDGLDCPAAGRVALKYMTPVILLVFALA
LYLHAQQVESTARLDFLWKLQATGEKEEMEELQ
AYNRRLLHNILPKDVAAHFLARERRNDELYYQS
CECVAVMFASIANFSEFYVELEANNEGVECLRLL
NEIIADFDEIISEERFRQLEKIKTIGSTYMAAS
GLNASTYDQVGRSHITALADYAMRLMEQMKHIN
EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWG
NTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY
QLECRGVVKVKGKGEMTTYFLNGGPSS*QGPAT
NSAEGTKVGIEWTLCSLGGAVAGGTEPPDPANHK
REHPSRLCLDHARLPSSWKTRGYLPRGLCK*LS
FLLGVGLFPLQSSSLWEQGRGQ*QKQREASCLR
D*NGSLPCLPFPVCLGSRFRAEPFFSLFFPGNIL
YNILYKDRHEECLFHACLCNTCIPSTGPGHFPT
PARCPSYAQSRGGRSSGEPALAIFQENVSMCQI
LVP*SVPKGEQRDL*QLRFSPSSCTLQGTGCLAS
LVL*KMLREQACVWGCQVRSWKFTCRCQRAGRP
GLGQCQTLI*GPRRGPDQVTLPQCSLAVC*QGG
MEHLFLFCCQIEKGQGMEKGDPDPKPALPSLWCW
GGPVCLCNCVCMLVFVCISVFQVYVSPCAPAPQ
LSTPGCLSPVGLCLLGIKQGFLLQGM*RDAQVA
QEWDGVW*QKEGEESFLCQIPKCRSGAMCAA*LS
LSVAGTQALA*APVLHAST*TVWGLMDRG*GIS
WLPQIVSWDMVCFGAGVAWNPSEDLDTGTTGWG
RGTLNLAFPSLQPESSMFLAPQSLVKP*GLAEGL
GG*TLDSLPVFAFLLPLSLQPP*LWPEFVGASV
SLSVPI*AKGTSLNFA*RSLCLGND*RGRGEGF
PELLGLGVEGAGSALAPPHAPSDTSSLWRPGFWV
MPPLGIFMHQPNGPSGTSLVMAEGGEKTCFPDR
KSTPLSPAISLDRKG*EETTWCHGVGVRV*VDQ
SGKTSALGGLSLLLARWEGLSTPWIPVPQCQPCP
SPGLPLSLSSPSW*RSQEVGGRGLWFYNVTTVG
VGEDGEPCISVKYLIYLNINKIKLF

Frame 2

DGGRRAGRPGRAGSEDRGTAGRPAGARGGGGAG
AQGRRGAGPAATCHGLVASWSLKWMNGKQPGVN
AMGRSVRGAVALGQVASARPAI*AASGMQSHPA
PPLRAPLGAPGRMTPSSGGAAQARARSWGCGQWP
WASRIPR*QRQRAGRLRWRPTRCPGVGDPAGAV
WCRCSSRSSSVRPSWSACTSGTSSR*TRAA*RC
*WRCWCCSQRCCWLSTPHPPALSLPMWHCWPVPP
PCSWGSWWCVTGIASARTPCGW*ATWCWASWRQ
CRSGALSQQTRAAPLRASGALCSLSTSPTRSSP
SACGLPSSAAWASPPCI*SWPGNLTVVMPSSGSS
SVPMCCCSSAPTSLASAHTIQQRCLSARPFRRP
AVTSRPGSTCSMRIGSRSGCCCRYCPSTLPWR*
KKTSTQKKKT*CSTRSTYRSMTMSASCLQTLRAS
PAWHPSALRRSWS*P*MSSLPGLTSWLRRITA*
GSRSWGTVTTVCQGCRRPGPTMPTAVWRWG*T*
LRPSRWYVR*QV*M*TCAWASTAGACTAASLACG
NGSSMCGPMM*PWPTTWRQEAGLAASTSLGQHC
ST*TGTTRWSQAVVASATRTSRSSTLRLSSSWA
PARNGKRRRPCWPSCSGLGPTPWKG*CRAGFLIV
PSPGPRTPRPSARWALMIPAKTTGAPKMP*TLR
MRWMSS*AVPSMPAALISCGRTMCAGFCSPSRE
RILRRSTPGRWIPASEPTLPVPCWSSASSASSSF
SSSHTPP*CLGSMPASSCCC*SPC*SVLCTPVV
LCSLRPCNVCPAALSAHGHIAPQLASFPSCLCL
LLPLPTCTSSGTCC*VSWPALSSCTSAASGSWP*
SLSWGSSIWCCFCWVPQPPSLTTMTYCLASMAW
LLPMRPLMGWTVQLQGGWPSNI*PL*FCWCLRW
RCICMLSRWSRLPA*TSSGNYRQQGRRRRWRSYR
HTTGGCCITFCPRTWRPTSWPGSAAMMNSTISR
VSVWLLCLPPLPTSLSSMWSWRQTMRVSSACGC
STRSSLTLMRLSARSGSGSWKRSRRLVAPTWLPQ
G*TPAPTIRWAAPTSLPWLTTPCGSWSR*STSM
STPSTISR*RLG*TWAQSWQVSSGLGSHSMTSG
GTQ*MSLVVWTARGSPTESR*PRTCTRF*LPRAT
SWSVEGWSR*RARGR*PPTSSMGAPAVNRAQPQ
IQLKGPRWALSGLCAHWVELWQGALSLQTLLTT
KGNIPAGCAWIMLVCPQAGKQGATYREDYASDFL
SYLG*GCSLSNLPAFGSRGGVSSRSRGRPLA*G
IKMAACHAYPSLSVWAAGSGLSPSFPSFFLGIF
CTIFCTKTGMRSAYSMLAFAIPASPALVLGTSPP
QPGVPPMHRAEEGEALGSQLWPYFRRMFPCAKS
*SHDLSPKGNKGTSDSLDLAPVPARSRERGVWP
HWYCEKCSESKPVCGDVRSGAGSSPAGAKEQAGQ
GWGSARL*SEDPVGVQIRSLCPSALLLSADKGA
WSISSSSVAK*KRVRAWRKVTLIPNLPSQVSGV
GEGPCVCVTVCACWSLCAYLFSRSM*VLVLLLLS
SPPQVASLLWASVFWE*SRVSYFRGCREMPRLH
RSGMGCGSKRRERSPFCAKSLSAVRGPCVQHDS
PCLWQGPKRLLKPQCSMPALELSGV*WTEAEEFP
GFPR*CPGTWYALGLG*HGIPLRTWILVLRGGE
EEP*TWLSPAFSLSLACF*LPSPL*SLEGWQKG
*EVEL*IPFLSLPSFYPFPCNLLDSGLNLLVPQF
LCLYLFKPKALA*ILLEDHFVLEMTREAEEKGF
QSC*VWEWKGQAVHLPLLMPLLTPAPCGGLVSG
*CLPWASSCINQMGHQVLH*SWQKEGKRLVFQTE
NLLPCPQPYPWIGRDRKRLLGAMG*G*GYK*IR
VGRPQPWVACLCFLPGGRACPHPGSPYHSASHA
LPLGYHCPFPHPVGRGVRRWEAVGFGFIM*PLWG
WGRMVNHVFQ*NI*YI*ISIKSNSL

Sequence NM_015270

CCGGTCTATAGGTGCATACCACCACACCAGGCTAATTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCGCGATCTTT
GCTCACTGCAACCTCTGCCACCCGGGTTCAAGCAATTCTCCTGCCTCAGCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTT
TGTATTTTTAGTAGAGACGAGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACTCCTGACCTTGTGATCTACCTGCCAGGGCCTTCCAAAGTGCTGGGAT
TACGGACGTGAGCCACCACGCCTGGCCCAGGCTAATTTTTTGAAATTTTAATAGAGGCAGGGTCTTGCTGTATTGCCCAGGTTGCTCTCACATTCCTAGC
CTTAAGCCATCCTCCTATCTCGGCCTCACAAAGTGCTGGGATTACAGGTGTAAGCCACTGTGCCTGGTTTTGGGCAAGTTTCTTGTCCTGACTGTGTCTT
GGGTTCTCACCTGTTGATTGGGGATACCCTTGTTGCCTACCTCCAAGTAATTTTATGAGGATGAAACTCATAGCTTGTCAGTGGGAAGTGCTTAGGTAAT
GAGCTACTAGTGGTGGCAGTGGCTGTGATGGTGGTATTAATACCACTCCTACTGGATGGTCTCTAATACTATCTCCTTCCTTCCCTACCAGCAACATGTC
ATGGTTTAGTGGCCTCCTGGTCCCTAAAGTGGATGAACGGAAAACAGCCTGGGGTGAACGCAATGGGCAGAAGCGTTCGCGGCGCCGTGGCACTCGGGCA
GGTGGCTTCTGCACGCCCCGCTATATGAGCTGCCTCCGGGATGCAGAGCCACCCAGCCCCACCCCTGCGGGCCCCCCTCGGTGCCCCTGGCAGGATGACG
CCTTCATCCGGAGGGGCGGCCCAGGCAAGGGCAAGGAGCTGGGGCTGCGGGCAGTGGCCCTGGGCTTCGAGGATACCGAGGTGACAACGACAGCGGGCGG
GACGGCTGAGGTGGCGCCCGACGCGGTGCCCAGGAGTGGGCGATCCTGCTGGCGCCGTCTGGTGCAGGTGTTCCAGTCGAAGCAGTTCCGTTCGGCCAAG
CTGGAGCGCCTGTACCAGCGGTACTTCTTCCAGATGAACCAGAGCAGCCTGACGCTGCTGATGGCGGTGCTGGTGCTGCTCACAGCGGTGCTGCTGGCTT
TCCACGCCGCACCCGCCCGCCCTCAGCCTGCCTATGTGGCACTGTTGGCCTGTGCCGCCGCCCTGTTCGTGGGGCTCATGGTGGTGTGTAACCGGCATAG
CTTCCGCCAGGACTCCATGTGGGTGGTGAGCTACGTGGTGCTGGGCATCCTGGCGGCAGTGCAGGTCGGGGGCGCTCTCGCAGCAGACCCGCGCAGCCCC
TCTGCGGGCCTCTGGTGCCCTGTGTTCTTTGTCTACATCGCCTACACGCTCCTCCCCATCCGCATGCGGGCTGCCGTCCTCAGCGGCCTGGGCCTCTCCA
CCTTGCATTTGATCTTGGCCTGGCAACTTAACCGTGGTGATGCCTTCCTCTGGAAGCAGCTCGGTGCCAATGTGCTGCTGTTCCTCTGCACCAACGTCAT
TGGCATCTGCACACACTATCCAGCAGAGGTGTCTCAGCGCCAGGCCTTTCAGGAGACCCGCGGTTACATCCAGGCCCGGCTCCACCTGCAGCATGAGAAT
CGGCAGCAGGAGCGGCTGCTGCTGTCGGTATTGCCCCAGCACGTTGCCATGGAGATGAAAGAAGACATCAACACAAAAAAAGAAGACATGATGTTCCACA
AGATCTACATACAGAAGCATGACAATGTCAGCATCCTGTTTGCAGACATTGAGGGCTTCACCAGCCTGGCATCCCAGTGCACTGCGCAGGAGCTGGTCAT
GACCCTGAATGAGCTCTTTGCCCGGTTTGACAAGCTGGCTGCGGAGAATCACTGCCTGAGGATCAAGATCTTGGGGGACTGTTACTACTGTGTGTCAGGG
CTGCCGGAGGCCCGGGCCGACCATGCCCACTGCTGTGTGGAGATGGGGGTAGACATGATTGAGGCCATCTCGCTGGTACGTGAGGTGACAGGTGTGAATG
TGAACATGCGCGTGGGCATCCACAGCGGGCGCGTGCACTGCGGCGTCCTTGGCTTGCGGAAATGGCAGTTCGATGTGTGGTCCAATGATGTGACCCTGGC
CAACCACATGGAGGCAGGAGGCCGGGCTGGCCGCATCCACATCACTCGGGCAACACTGCAGTACCTGAACGGGGACTACGAGGTGGAGCCAGGCCGTGGT
GGCGAGCGCAACGCGTACCTCAAGGAGCAGCACATTGAGACTTTCCTCATCCTGGGCGCCAGCCAGAAACGGAAAGAGGAGAAGGCCATGCTGGCCAAGC
TGCAGCGGACTCGGGCCAACTCCATGGAAGGGCTGATGCCGCGCTGGGTTCCTGATCGTGCCTTCTCCCGGACCAAGGACTCCAAGGCCTTCCGCCAGAT
GGGCATTGATGATTCCAGCAAAGACAACCGGGGCACCCAAGATGCCCTGAACCCTGAGGATGAGGTGGATGAGTTCCTGAGCCGTGCCATCGATGCCCGC
AGCATTGATCAGCTGCGGAAGGACCATGTGCGCCGGTTTCTGCTCACCTTCCAGAGAGAGGATCTTGAGAAGAAGTACTCCCGGAAGGTGGATCCCCGCT
TCGGAGCCTACGTTGCCTGTGCCCTGTTGGTCTTCTGCTTCATCTGCTTCATCCAGCTTCTCATCTTCCCACACTCCACCCTGATGCTTGGGATCTATGC
CAGCATCTTCCTGCTGCTGCTAATCACCGTGCTGATCTGTGCTGTGTACTCCTGTGGTTCTCTGTTCCCTAAGGCCCTGCAACGTCTGTCCCGCAGCATT
GTCCGCTCACGGGCACATAGCACCGCAGTTGGCATCTTTTCCGTCCTGCTTGTGTTTACTTCTGCCATTGCCAACATGTTCACCTGTAACCACACCCCCA
TACGGAGCTGTGCAGCCCGGATGCTGAATTTAACACCTGCTGACATCACTGCCTGCCACCTGCAGCAGCTCAATTACTCTCTGGGCCTGGATGCTCCCCT
GTGTGAGGGCACCATGCCCACCTGCAGCTTTCCTGAG
TACTTCATCGGGAACATGCTGCTGAGTCTCTTGGCCAGCTCTGTCTTCCTGCACATCAGCAGC
ATCGGGAAGTTGGCCATGATCTTTGTCTTGGGGCTCATCTATTTGGTGCTGCTTCTGCTGGGTCCCCCAGCCACCATCTTTGACAACTATGACCTACTGC
TTGGCGT
CCATGGCTTGGCTTCTTCCAATGAGACCTTTGATGGGCTGGACTGTCCAGCTGCAGGGAGGGTGGCCCTCAAATATATGACCCCTGTGATTCT
GCTGGTGTTTGCGCTGGCGCTGTATCTGCATGCTCAGCAGGTGGAGTCGACTGCCCGCCTAGACTTCCTCTGGAAACTACAGGCAACAGGGGAGAAGGAG
GAGATGGAGGAGCTACAGGCATACAACCGGAGGCTGCTGCATAACATTCTGCCCAAGGACGTGGCGGCCCACTTCCTGGCCCGGGAGCGCCGCAATGATG
AACTCTACTATCAGTCGTGTGAGTGTGTGGCTGTTATGTTTGCCTCCATTGCCAACTTCTCTGAGTTCTATGTGGAGCTGGAGGCAAACAATGAGGGTGT
CGAGTGCCTGCGGCTGCTCAACGAGATCATCGCTGACTTTGATGAGATTATCAGCGAGGAGCGGTTCCGGCAGCTGGAAAAGATCAAGACGATTGGTAGC
ACCTACATGGCTGCCTCAGGGCTGAACGCCAGCACCTACGATCAGGTGGGCCGCTCCCACATCACTGCCCTGGCTGACTACGCCATGCGGCTCATGGAGC
AGATGAAGCACATCAATGAGCACTCCTTCAACAATTTCCAGATGAAGATTGGGCTGAACATGGGCCCAGTCGTGGCAGGTGTCATCGGGGCTCGGAAGCC
ACAGTATGACATCTGGGGGAACACAGTGAATGTCTCTAGTCGTATGGACAGCACGGGGGTCCCCGACCGAATCCAGGTGACCACGGACCTGTACCAGGTT
CTAGCTGCCAAGGGCTACCAGCTGGAGTGTCGAGGGGTGGTCAAGGTGAAGGGCAAGGGGGAGATGACCACCTACTTCCTCAATGGGGGCCCCAGCAGTT
AACAGGGCCCAGCCACAAATTCAGCTGAAGGGACCAAGGTGGGCATTGAGTGGACTCTGTGCTCACTGGGTGGAGCTGTGGCAGGGGGCACTGAGCCTCC
AGACCCTGCTAACCACAAAAGGGAACATCCCAGCAGGCTGTGCTTGGATCATGCTCGTCTGCCCTCAAGCTGGAAAACAAGGGGCTACCTACCGAGAGGA
TTATGCAAGTGACTTTCTTTCTTACTTGGGGTAGGGCTGTTCCCTCTCCAATCTTCCAGCCTTTGGGAGCAGGGGAGGGGTCAGTAGCAGAAGCAGAGGG
AGGCCTCTTGCCTGAGGGATTAAAATGGCAGCTTGCCATGCCTACCCTTCCCTGTCTGTCTGGGCAGCAGGTTCAGGGCTGAGCCCTTCTTTTCCCTCTT
TTTTCCTGGGAATATTTTGTACAATATTTTGTACAAAGACAGGCATGAGGAGTGCCTATTCCATGCTTGCCTTTGCAATACCTGCATCCCCAGCACTGGT
CCTGGGCACTTCCCCACCCCAGCCAGGTGTCCCTCCTATGCACAGAGCAGAGGAGGGAGAAGCTCTGGGGAGCCAGCTTTGGCCATATTTCAGGAGAATG
TTTCCATGTGCCAAATCTTAGTCCCATGATCTGTCCCCAAAGGGGAACAAAGGGACCTCTGACAGCTTAGATTTAGCCCCAGTTCCTGCACGCTCCAGGG
AACGGGGTGTCTGGCCTCACTGGTACTGTGAAAAATGCTCAGAGAGCAAGCCTGTGTGTGGGGATGTCAGGTCAGGAGCTGGAAGTTCACCTGCAGGTGC
CAAAGAGCAGGCCGGCCAGGGCTGGGGCAGTGCCAGACTCTGATCTGAGGACCCCGTCGGGGTCCAGATCAGGTCACTCTGCCCCAGTGCTCTCTTGCTG
TCTGCTGACAAGGGGGCATGGAGCATCTCTTCCTCTTCTGTTGCCAAATAGAAAAGGGTCAGGGCATGGAGAAAGGTGACCCTGATCCCAAACCTGCCCT
CCCAAGTCTCTGGTGTTGGGGAGGGCCCGTGTGTTTGTGTAACTGTGTGTGCATGTTGGTCTTTGTGTGCATATCTGTTTTCCAGGTCTATGTGAGTCCT
TGTGCTCCTGCTCCTCAGCTCTCCACCCCAGGTTGCCTCTCTCCTGTGGGCCTCTGTCTTCTGGGAATAAAGCAGGGTTTCCTACTTCAGGGGATGTAGA
GAGATGCCCAGGTTGCACAGGAGTGGGATGGGGTGTGGTAGCAAAAGGAGGGAGAGGAGTCCTTTTTGTGCCAAATCCCTAAGTGCCGTTCGGGGGCCAT
GTGTGCAGCATGACTCTCCCTGTCTGTGGCAGGGACCCAAGCGCTTGCTTAAGCCCCAGTGCTCCATGCCAGCACTTGAACTGTCTGGGGTTTGATGGAC
AGAGGCTGAGGAATTTCCTGGCTTCCCCAGATAGTGTCCTGGGACATGGTATGCTTTGGGGCTGGGGTAGCATGGAATCCCTCTGAGGACCTGGATACTG
GTACTACGGGGTGGGGAAGAGGAACCTTAAACTTGGCTTTCCCCAGCCTTCAGCCTGAGTCTAGCATGTTTCTAGCTCCCCAGTCCCTTGTGAAGCCTTG
AGGGCTGGCAGAAGGGTTAGGAGGTTGAACTCTAGATTCCCTTCCTGTCTTTGCCTTCCTTTTACCCCTTTCCCTGCAACCTCCTTGACTCTGGCCTGAA
TTTGTTGGTGCCTCAGTTTCTCTGTCTGTACCTATTTAAGCCAAAGGCACTAGCCTGAATTTTGCTTGAAGATCACTTTGTCTTGGAAATGACTAGAGAG
GCAGAGGAGAAGGGTTTCCAGAGTTGCTAGGTTTGGGAGTGGAAGGGGCAGGCAGTGCACTTGCCCCTCCTCATGCCCCTTCTGACACCAGCTCCCTGTG
GAGGCCTGGTTTCTGGGTAATGCCTCCCTTGGGCATCTTCATGCATCAACCAAATGGGCCATCAGGTACTTCATTAGTCATGGCAGAAGGAGGGGAAAAG
ACTTGTTTTCCAGACAGAAAATCTACTCCCCTGTCCCCAGCCATATCCCTGGATAGGAAGGGATAGGAAGAGACTACTTGGTGCCATGGGGTAGGGGTGA
GGGTATAAGTAGATCAGAGTGGGAAGACCTCAGCCTTGGGTGGCTTGTCTCTGCTTCTTGCCAGGTGGGAGGGCCTGTCCACACCCTGGATCCCCGTACC
ACAGTGCCAGCCATGCCCTTCCCCTGGGCTACCATTGTCCCTTTCCTCACCCAGTTGGTAGAGGAGTCAGGAGGTGGGAGGCCGTGGGCTTTGGTTTTAT
AATGTAACCACTGTGGGGGTGGGGGAGGATGGTGAACCATGTATTTCAGTGAAATATTTAATATATTTAAATATCAATAAAATCAAACTCTTTGT
  • refseq_ADCY6.F1 (forward primer)
  • refseq_ADCY6.R1 (reverse primer)
  • Single exon skipping

Frame 0

PVYRCIPPHQANFFFFETESHSVTQAGVQWRDL
CSLQPLPPGFKQFSCLSS*VAGITGARHHARLIF
VFLVETRFHHLGQAGLELLTL*STCQGLPKCWD
YGREPPRLAQANFLKF**RQGLAVLPRLLSHS*
P*AILLSRPHKVLGLQV*ATVPGFGQVSCPDCVL
GSHLLIGDTLVAYLQVIL*G*NS*LVSGKCLGN
ELLVVAVAVMVVLIPLLLDGL*YYLLPSLPATC
HGLVASWSLKWMNGKQPGVNAMGRSVRGAVALGQ
VASARPAI*AASGMQSHPAPPLRAPLGAPGRMT
PSSGGAAQARARSWGCGQWPWASRIPR*QRQRA
GRLRWRPTRCPGVGDPAGAVWCRCSSRSSSVRPS
WSACTSGTSSR*TRAA*RC*WRCWCCSQRCCWL
STPHPPALSLPMWHCWPVPPPCSWGSWWCVTGI
ASARTPCGW*ATWCWASWRQCRSGALSQQTRAAP
LRASGALCSLSTSPTRSSPSACGLPSSAAWASP
PCI*SWPGNLTVVMPSSGSSSVPMCCCSSAPTS
LASAHTIQQRCLSARPFRRPAVTSRPGSTCSMRI
GSRSGCCCRYCPSTLPWR*KKTSTQKKKT*CST
RSTYRSMTMSASCLQTLRASPAWHPSALRRSWS
*P*MSSLPGLTSWLRRITA*GSRSWGTVTTVCQG
CRRPGPTMPTAVWRWG*T*LRPSRWYVR*QV*M
*TCAWASTAGACTAASLACGNGSSMCGPMM*PW
PTTWRQEAGLAASTSLGQHCST*TGTTRWSQAVV
ASATRTSRSSTLRLSSSWAPARNGKRRRPCWPS
CSGLGPTPWKG*CRAGFLIVPSPGPRTPRPSAR
WALMIPAKTTGAPKMP*TLRMRWMSS*AVPSMPA
ALISCGRTMCAGFCSPSRERILRRSTPGRWIPA
SEPTLPVPCWSSASSASSSFSSSHTPP*CLGSM
PASSCCC*SPC*SVLCTPVVLCSLRPCNVCPAAL
SAHGHIAPQLASFPSCLCLLLPLPTCSPVTTPP
YGAVQPGC*I*HLLTSLPATCSSSITLWAWMLP
CVRAPCPPAAFLS
TSSGTCC*VSWPALSSCTSAA
SGSWP*SLSWGSSIWCCFCWVPQPPSLTTMTYC
LA
SMAWLLPMRPLMGWTVQLQGGWPSNI*PL*F
CWCLRWRCICMLSRWSRLPA*TSSGNYRQQGRRR
RWRSYRHTTGGCCITFCPRTWRPTSWPGSAAMM
NSTISRVSVWLLCLPPLPTSLSSMWSWRQTMRV
SSACGCSTRSSLTLMRLSARSGSGSWKRSRRLVA
PTWLPQG*TPAPTIRWAAPTSLPWLTTPCGSWS
R*STSMSTPSTISR*RLG*TWAQSWQVSSGLGS
HSMTSGGTQ*MSLVVWTARGSPTESR*PRTCTRF
*LPRATSWSVEGWSR*RARGR*PPTSSMGAPAV
NRAQPQIQLKGPRWALSGLCAHWVELWQGALSL
QTLLTTKGNIPAGCAWIMLVCPQAGKQGATYRED
YASDFLSYLG*GCSLSNLPAFGSRGGVSSRSRG
RPLA*GIKMAACHAYPSLSVWAAGSGLSPSFPS
FFLGIFCTIFCTKTGMRSAYSMLAFAIPASPALV
LGTSPPQPGVPPMHRAEEGEALGSQLWPYFRRM
FPCAKS*SHDLSPKGNKGTSDSLDLAPVPARSR
ERGVWPHWYCEKCSESKPVCGDVRSGAGSSPAGA
KEQAGQGWGSARL*SEDPVGVQIRSLCPSALLL
SADKGAWSISSSSVAK*KRVRAWRKVTLIPNLP
SQVSGVGEGPCVCVTVCACWSLCAYLFSRSM*VL
VLLLLSSPPQVASLLWASVFWE*SRVSYFRGCR
EMPRLHRSGMGCGSKRRERSPFCAKSLSAVRGP
CVQHDSPCLWQGPKRLLKPQCSMPALELSGV*WT
EAEEFPGFPR*CPGTWYALGLG*HGIPLRTWIL
VLRGGEEEP*TWLSPAFSLSLACF*LPSPL*SL
EGWQKG*EVEL*IPFLSLPSFYPFPCNLLDSGLN
LLVPQFLCLYLFKPKALA*ILLEDHFVLEMTRE
AEEKGFQSC*VWEWKGQAVHLPLLMPLLTPAPC
GGLVSG*CLPWASSCINQMGHQVLH*SWQKEGKR
LVFQTENLLPCPQPYPWIGRDRKRLLGAMG*G*
GYK*IRVGRPQPWVACLCFLPGGRACPHPGSPY
HSASHALPLGYHCPFPHPVGRGVRRWEAVGFGFI
M*PLWGWGRMVNHVFQ*NI*YI*ISIKSNSL

Frame 1

RSIGAYHHTRLIFFFLRRSLTLSPRLECNGAIF
AHCNLCHPGSSNSPASAPE*LGLQAPATTPG*F
LYF**RRGFTILARLVLNS*PCDLPARAFQSAGI
TDVSHHAWPRLIF*NFNRGRVLLYCPGCSHIPS
LKPSSYLGLTKCWDYRCKPLCLVLGKFLVLTVS
WVLTC*LGIPLLPTSK*FYEDETHSLSVGSA*VM
SY*WWQWL*WWY*YHSYWMVSNTISFLPYQQHV
MV*WPPGP*SG*TENSLG*TQWAEAFAAPWHSG
RWLLHAPLYELPPGCRATQPHPCGPPSVPLAG*R
LHPEGRPRQGQGAGAAGSGPGLRGYRGDNDSGR
DG*GGARRGAQEWAILLAPSGAGVPVEAVPFGQ
AGAPVPAVLLPDEPEQPDAADGGAGAAHSGAAGF
PRRTRPPSACLCGTVGLCRRPVRGAHGGV*PA*
LPPGLHVGGELRGAGHPGGSAGRGRSRSRPAQP
LCGPLVPCVLCLHRLHAPPHPHAGCRPQRPGPLH
LAFDLGLAT*PW*CLPLEAARCQCAAVPLHQRH
WHLHTLSSRGVSAPGLSGDPRLHPGPAPPAA*E
SAAGAAAAVGIAPARCHGDERRHQHKKRRHDVPQ
DLHTEA*QCQHPVCRH*GLHQPGIPVHCAGAGH
DPE*ALCPV*QAGCGESLPEDQDLGGLLLLCVR
AAGGPGRPCPLLCGDGGRHD*GHLAGT*GDRCEC
EHARGHPQRARALRRPWLAEMAVRCVVQ*CDPG
QPHGGRRPGWPHPHHSGNTAVPERGLRGGARPW
WRAQRVPQGAAH*DFPHPGRQPETERGEGHAGQA
AADSGQLHGRADAALGS*SCLLPDQGLQGLPPD
GH**FQQRQPGHPRCPEP*G*GG*VPEPCHRCP
QH*SAAEGPCAPVSAHLPERGS*EEVLPEGGSPL
RSLRCLCPVGLLLHLLHPASHLPTLHPDAWDLC
QHLPAAANHRADLCCVLLWFSVP*GPATSVPQH
CPLTGT*HRSWHLFRPACVYFCHCQHVHL*PHPH
TELCSPDAEFNTC*HHCLPPAAAQLLSGPGCSP
V*GHHAHLQLS*
VLHREHAAESLGQLCLPAHQQ
HREVGHDLCLGAHLFGAASAGSPSHHL*QL*PTA
WR
PWLGFFQ*DL*WAGLSSCREGGPQIYDPCDS
AGVCAGAVSACSAGGVDCPPRLPLETTGNRGEG
GDGGATGIQPEAAA*HSAQGRGGPLPGPGAPQ**
TLLSVV*VCGCYVCLHCQLL*VLCGAGGKQ*GC
RVPAAAQRDHR*L**DYQRGAVPAAGKDQDDW*
HLHGCLRAERQHLRSGGPLPHHCPG*LRHAAHGA
DEAHQ*ALLQQFPDEDWAEHGPSRGRCHRGSEA
TV*HLGEHSECL*SYGQHGGPRPNPGDHGPVPG
SSCQGLPAGVSRGGQGEGQGGDDHLLPQWGPQQL
TGPSHKFS*RDQGGH*VDSVLTGWSCGRGH*AS
RPC*PQKGTSQQAVLGSCSSALKLENKGLPTER
IMQVTFFLTWGRAVPSPIFQPLGAGEGSVAEAEG
GLLPEGLKWQLAMPTLPCLSGQQVQG*ALLFPL
FSWEYFVQYFVQRQA*GVPIPCLPLQYLHPQHW
SWALPHPSQVSLLCTEQRREKLWGASFGHISGEC
FHVPNLSPMICPQRGTKGPLTA*I*PQFLHAPG
NGVSGLTGTVKNAQRASLCVGMSGQELEVHLQV
PKSRPARAGAVPDSDLRTPSGSRSGHSAPVLSCC
LLTRGHGASLPLLLPNRKGSGHGER*P*SQTCP
PKSLVLGRARVFV*LCVHVGLCVHICFPGLCES
LCSCSSALHPRLPLSCGPLSSGNKAGFPTSGDVE
RCPGCTGVGWGVVAKGGRGVLFVPNP*VPFGGH
VCSMTLPVCGRDPSACLSPSAPCQHLNCLGFDG
QRLRNFLASPDSVLGHGMLWGWGSMESL*GPGYW
YYGVGKRNLKLGFPQPSA*V*HVSSSPVPCEAL
RAGRRVRRLNSRFPSCLCLPFTPFPATSLTLA*
ICWCLSFSVCTYLSQRH*PEFCLKITLSWK*LER
QRRRVSRVARFGSGRGRQCTCPSSCPF*HQLPV
EAWFLGNASLGHLHASTKWAIRYFISHGRRRGK
DLFSRQKIYSPVPSHIPG*EGIGRDYLVPWGRGE
GISRSEWEDLSLGWLVSASCQVGGPVHTLDPRT
TVPAMPFPWATIVPFLTQLVEESGGGRPWALVL
*CNHCGGGGGW*TMYFSEIFNIFKYQ*NQTLC

Frame 2

GL*VHTTTPG*FFFF*DGVSLCHPGWSAMARSL
LTATSATRVQAILLPQLLSSWDYRRPPPRPANF
CIFSRDEVSPSWPGWS*TPDLVIYLPGPSKVLG
LRT*ATTPGPG*FFEILIEAGSCCIAQVALTFLA
LSHPPISASQSAGITGVSHCAWFWASFLS*LCL
GFSPVDWGYPCCLPPSNFMRMKLIACQWEVLR*
*ATSGGSGCDGGINTTPTGWSLILSPSFPTSNMS
WFSGLLVPKVDERKTAWGERNGQKRSRRRGTRA
GGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDD
AFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGG
TAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAK
LERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLA
FHAAPARPQPAYVALLACAAALFVGLMVVCNRHS
FRQDSMWVVSYVVLGILAAVQVGGALAADPRSP
SAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLS
TLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVI
GICTHYPAEVSQRQAFQETRGYIQARLHLQHEN
RQQERLLLSVLPQHVAMEMKEDINTKKEDMMFH
KIYIQKHDNVSILFADIEGFTSLASQCTAQELVM
TLNELFARFDKLAAENHCLRIKILGDCYYCVSG
LPEARADHAHCCVEMGVDMIEAISLVREVTGVN
VNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLA
NHMEAGGRAGRIHITRATLQYLNGDYEVEPGRG
GERNAYLKEQHIETFLILGASQKRKEEKAMLAK
LQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQM
GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDAR
SIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPR
FGAYVACALLVFCFICFIQLLIFPHSTLMLGIYA
SIFLLLLITVLICAVYSCGSLFPKALQRLSRSI
VRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTP
IRSCAARMLNLTPADITACHLQQLNYSLGLDAPL
CEGTMPTCSFPE
YFIGNMLLSLLASSVFLHISS
IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL
LGV
HGLASSNETFDGLDCPAAGRVALKYMTPVIL
LVFALALYLHAQQVESTARLDFLWKLQATGEKE
EMEELQAYNRRLLHNILPKDVAAHFLARERRND
ELYYQSCECVAVMFASIANFSEFYVELEANNEGV
ECLRLLNEIIADFDEIISEERFRQLEKIKTIGS
TYMAASGLNASTYDQVGRSHITALADYAMRLME
QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP
QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQV
LAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
*QGPATNSAEGTKVGIEWTLCSLGGAVAGGTEPP
DPANHKREHPSRLCLDHARLPSSWKTRGYLPRG
LCK*LSFLLGVGLFPLQSSSLWEQGRGQ*QKQR
EASCLRD*NGSLPCLPFPVCLGSRFRAEPFFSLF
FPGNILYNILYKDRHEECLFHACLCNTCIPSTG
PGHFPTPARCPSYAQSRGGRSSGEPALAIFQEN
VSMCQILVP*SVPKGEQRDL*QLRFSPSSCTLQG
TGCLASLVL*KMLREQACVWGCQVRSWKFTCRC
QRAGRPGLGQCQTLI*GPRRGPDQVTLPQCSLA
VC*QGGMEHLFLFCCQIEKGQGMEKGDPDPKPAL
PSLWCWGGPVCLCNCVCMLVFVCISVFQVYVSP
CAPAPQLSTPGCLSPVGLCLLGIKQGFLLQGM*
RDAQVAQEWDGVW*QKEGEESFLCQIPKCRSGAM
CAA*LSLSVAGTQALA*APVLHAST*TVWGLMD
RG*GISWLPQIVSWDMVCFGAGVAWNPSEDLDT
GTTGWGRGTLNLAFPSLQPESSMFLAPQSLVKP*
GLAEGLGG*TLDSLPVFAFLLPLSLQPP*LWPE
FVGASVSLSVPI*AKGTSLNFA*RSLCLGND*R
GRGEGFPELLGLGVEGAGSALAPPHAPSDTSSLW
RPGFWVMPPLGIFMHQPNGPSGTSLVMAEGGEK
TCFPDRKSTPLSPAISLDRKG*EETTWCHGVGV
RV*VDQSGKTSALGGLSLLLARWEGLSTPWIPVP
QCQPCPSPGLPLSLSSPSW*RSQEVGGRGLWFY
NVTTVGVGEDGEPCISVKYLIYLNINKIKLF

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