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Sequences

Sequence NM_175863

CGGCCGCCGCCGGCACCCACAGCGCCAAGAGCGGCGGCTCCGAGGCGGCTCTCAAGGAGGGTGGAAGCGCCGCCGCGCTGTCCTCCTCCTCCTCCTCCTC CGCGGCGGCAGCGGCGGCATCCTCTTCCTCCTCGTCGGGCCCGGGCTCGGCCATGGAGACGGGGCTGCTCCCCAACCACAAACTGAAAACCGTTGGCGAA GCCCCCGCCGCGCCGCCCCACCAGCAGCACCACCACCACCACCATGCCCACCACCACCACCACCATGCCCACCACCTCCACCACCACCACGCACTACAGC AGCAGCTAAACCAGTTCCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAACAGCAACATCCCATTTCCAACAACAACAGCTTGGG CGGCGCGGGCGGCGGCGCGCCTCAGCCCGGCCCCGACATGGAGCAGCCGCAACATGGAGGCGCCAAGGACAGTGCTGCGGGCGGCCAGGCCGACCCCCCG GGCCCGCCGCTGCTGAGCAAGCCGGGCGACGAGGACGACGCGCCGCCCAAGATGGGGGAGCCGGCGGGCGGCCGCTACGAGCACCCGGGCTTGGGCGCCC TGGGCACGCAGCAGCCGCCGGTCGCCGTGCCCGGGGGCGGCGGCGGCCCGGCGGCCGTCCCGGAGTTTAATAATTACTATGGCAGCGCTGCCCCTGCGAG CGGCGGCCCCGGCGGCCGCGCTGGGCCTTGCTTTGATCAACATGGCGGACAACAAAGCCCCGGGATGGGGATGATGCACTCCGCCTCCGCCGCCGCCGCC GGGGCCCCCGGCAGCATGGACCCCCTGCAGAACTCCCACGAAGGGTACCCCAACAGCCAGTGCAACCATTATCCGGGCTACAGCCGGCCCGGCGCGGGCG GCGGCGGCGGCGGCGGCGGCGGAGGAGGAGGAGGCAGCGGAGGAGGAGGAGGAGGAGGAGGAGCAGGAGCAGGAGGAGCAGGAGCGGGAGCTGTGGCGGC GGCGGCCGCGGCGGCGGCGGCAGCAGCAGGAGGCGGCGGCGGCGGCGGCTATGGGGGCTCGTCCGCGGGGTACGGGGTGCTGAGCTCCCCCCGGCAGCAG GGCGGCGGCATGATGATGGGCCCCGGGGGCGGCGGGGCCGCGAGCCTCAGCAAGGCGGCCGCCGGCTCGGCGGCGGGGGGCTTCCAGCGCTTCGCCGGCC AGAACCAGCACCCGTCGGGGGCCACCCCGACCCTCAATCAGCTGCTCACCTCGCCCAGCCCCATGATGCGGAGCTACGGCGGCAGCTACCCCGAGTACAG CAGCCCCAGCGCGCCGCCGCCGCCGCCGTCGCAGCCCCAGTCCCAGGCGGCGGCGGCGGGGGCGGCGGCGGGCGGCCAGCAGGCGGCCGCGGGCATGGGC TTGGGCAAGGACATGGGCGCCCAGTACGCCGCTGCCAGCCCGGCCTGGGCGGCCGCGCAACAAAGGAGTCACCCGGCGATGAGCCCCGGCACCCCCGGAC CGACCATGGGCAGATCCCAGGGCAGCCCAATGGATCCAATGGTGATGAAGAGACCTCAGTTGTATGGCATGGGCAGTAACCCTCATTCTCAGCCTCAGCA GAGCAGTCCGTACCCAGGAGGTTCCTATGGCCCTCCAGGCCCACAGCGGTATCCAATTGGCATCCAGGGTCGGACTCCCGGGGCCATGGCCGGAATGCAG TACCCTCAGCAGCAGATGCCACCTCAGTATGGACAGCAAGGTGTGAGTGGTTACTGCCAGCAGGGCCAACAGCCATATTACAGCCAGCAGCCGCAGCCCC CGCACCTCCCACCCCAGGCGCAGTATCTGCCGTCCCAGTCCCAGCAGAGGTACCAGCCGCAGCAGGACATGTCTCAGGAAGGCTATGGAACTAGATCTCA ACCTCCTCTGGCCCCCGGAAAACCTAACCATGAAGACTTGAACTTAATACAGCAAGAAAGACCATCAAGTTTACCAGATCTGTCTGGCTCCATTGATGAC CTCCCCACGGGAACGGAAGCAACTTTGAGCTCAGCAGTCAGTGCATCCGGGTCCACGAGCAGCCAAGGGGATCAGAGCAACCCGGCGCAGTCGCCTTTCT CCCCACATGCGTCCCCTCATCTCTCCAGCATCCCGGGGGGCCCATCTCCCTCTCCTGTTGGCTCTCCTGTAGGAAGCAACCAGTCTCGATCTGGCCCAAT CTCTCCTGCAAGTATCCCAGGTAGTCAGATGCCTCCGCAGCCACCCGGGAGCCAGTCAGAATCCAGTTCCCATCCCGCCTTGAGCCAGTCACCAATGCCA CAGGAAAGAGGTTTTATGGCAGGCACACAAAGAAACCCTCAGATGGCTCAGTATGGACCTCAACAGACAGGACCATCCATGTCGCCTCATCCTTCTCCTG GGGGCCAGATGCATGCTGGAATCAGTAGCTTTCAGCAGAGTAACTCAAGTGGGACTTACGGTCCACAGATGAGCCAGTATGGACCACAAGGTAACTACTC CAGACCCCCAGCGTATAGTGGGGTGCCCAGTGCAAGCTACAGCGGCCCAGGGCCCGGTATGGGTATCAGTGCCAACAACCAGATGCATGGACAAGGGCCA AGCCAGCCATGTGGTGCTGTGCCCCTGGGACGAATGCCATCAGCTGGGATGCAGAACAGACCATTTCCTGGAAATATGAGCAGCATGACCCCCAGTTCTC CTGGCATGTCTCAGCAGGGAGGGCCAGGAATGGGGCCGCCAATGCCAACTGTGAACCGTAAGGCACAGGAGGCAGCCGCAGCAGTGATGCAGGCTGCTGC GAACTCAGCACAAAGCAGGCAAGGCAGTTTCCCCGGCATGAACCAGAGTGGACTTATGGCTTCCAGCTCTCCCTACAGCCAGCCCATGAACAACAGCTCT AGCCTGATGAACACGCAGGCGCCGCCCTACAGCATGGCGCCCGCCATGGTGAACAGCTCGGCAGCATCTGTGGGTCTTGCAGATATGATGTCTCCTGGTG AATCCAAACTGCCCCTGCCTCTCAAAGCAGACGGCAAAGAAGAAGGCACTCCACAGCCCGAGAGCAAGTCAAAGAAGTCCAGCTCCTCCACCACTACTGG GGAGAAGATCACGAAGGTGTACGAGCTGGGGAATGAGCCAGAGAGAAAGCTCTGGGTCGACCGATACCTCACCTTCATGGAAGAGAGAGGCTCTCCTGTC TCAAGTCTGCCTGCCGTGGGCAAGAAGCCCCTGGACCTGTTCCGACTCTACGTCTGCGTCAAAGAGATCGGGGGTTTGGCCCAGGTTAATAAAAACAAGA AGTGGCGTGAGCTGGCAACCAACCTAAACGTTGGCACCTCAAGCAGTGCAGCGAGCTCCCTGAAAAAGCAGTATATTCAGTACCTGTTTGCCTTTGAGTG CAAGATCGAACGTGGGGAGGAGCCCCCGCCGGAAGTCTTCAGCACCGGGGACACCAAAAAGCAGCCCAAGCTCCAGCCGCCATCTCCTGCTAACTCGGGA TCCTTGCAAGGCCCACAGACCCCCCAGTCAACTGGCAGCAATTCCATGGCAGAGGTTCCAGGTGACCTGAAGCCACCTACCCCAGCCTCCACCCCTCACG GCCAGATGACTCCAATGCAAGGTGGAAGAAGCAGTACAATCAGTGTGCACGACCCATTCTCAGATGTGAGTGATTCATCCTTCCCGAAACGGAACTCCAT GACTCCAAACGCCCCCTACCAGCAGGGCATGAGCATGCCCGATGTGATGGGCAGGATGCCCTATGAGCCCAACAAGGACCCCTTTGGGGGAATGAGAAAA GTGCCTGGAAGCAGCGAGCCCTTTATGACGCAAGGACAGATGCCCAACAGCAGCATGCAGGACATGTACAACCAAAGTCCCTCCGGAGCAATGTCTAACC TGGGCATGGGGCAGCGCCAGCAGTTTCCCTATGGAGCCAGTTACGACCGAAGGCATGAACCTTATGGGCAGCAGTATCCAGGCCAAGGCCCTCCCTCGGG ACAGCCGCCGTATGGAGGGCACCAGCCCGGCCTGTACCCACAGCAGCCGAATTACAAACGCCATATGGACGGCATGTACGGGCCCCCAGCCAAGCGCCAC GAGGGCGACATGTACAACATGCAGTACAGCAGCCAGCAGCAGGAGATGTACAACCAGTATGGAGGCTCCTACTCGGGCCCGGACCGCAGGCCCATCCAGG GCCAGTACCCGTATCCCTACAGCAGGGAGAGGATGCAGGGCCCGGGGCAGATCCAGACACACGGAATCCCGCCTCAGATGATGGGCGGCCCGCTGCAGTC GTCCTCCAGTGAGGGGCCTCAGCAGAATATGTGGGCAGCACGCAATGATATGCCTTATCCCTACCAGAACAGGCAGGGCCCTGGCGGCCCTACACAGGCG CCCCCTTACCCAGGCATGAACCGCACAGACGATATGATGGTACCCGATCAGAGGATAAATCATGAGAGCCAGTGGCCTTCTCACGTCAGCCAGCGTCAGC CTTATATGTCGTCCTCAGCCTCCATGCAGCCCATCACACGCCCACCACAGCCGTCCTACCAGACGCCACCGTCACTGCCAAATCACATCTCCAGGGCGCC CAGCCCAGCGTCCTTCCAGCGCTCCCTGGAGAACCGCATGTCTCCAAGCAAGTCTCCTTTTCTGCCGTCTATGAAGATGCAGAAGGTCATGCCCACGGTC CCCACATCCCAGGTCACCGGGCCACCACCCCAACCACCCCCAATCAGAAGGGAGATCACCTTTCCTCCTGGCTCAGTAGAAGCATCACAACCAGTCTTGA AACAAAGGCGAAAGATTACCTCCAAAGATATCGTTACTCCTGAGGCGTGGCGTGTGATGATGTCCCTTAAATCAGGTCTTTTGGCTGAGAGTACGTGGGC TTTGGACACTATTAATATTCTTCTGTATGATGACAGCACTGTTGCTACTTTCAATCTCTCCCAGTTGTCTGGATTTCTCGAACTTTTAGTCGAGTACTTT AGAAAATGCCTGATTGACATTTTTGGAATTCTTATGGAATATGAAGTGGGAGACCCCAGCCAAAAAGCACTTGATCACAACGCAGCAAGGAAGGATGACA GCCAGTCCTTGGCAGACGATTCTGGGAAAGAGGAGGAAGATGCTGAATGTATTGATGACGACGAGGAAGACGAGGAGGATGAGGAGGAAGACAGCGAGAA GACAGAAAGCGATGAAAAGAGCAGCATCGCTCTGACTGCCCCGGACGCCGCTGCAGACCCAAAGGAGAAGCCCAAGCAAGCCAGTAAGTTCGACAAGCTG CCAATAAAGATAGTCAAAAAGAACAACCTGTTTGTTGTTGACCGATCTGACAAGTTGGGGCGTGTGCAGGAGTTCAATAGTGGCCTTCTGCACTGGCAGC TCGGCGGGGGTGACACCACCGAGCACATTCAGACTCACTTTGAGAGCAAGATGGAAATTCCTCCTCGCAGGCGCCCACCTCCCCCCTTAAGCTCCGCAGG TAGAAAGAAAGAGCAAGAAGGCAAAGGCGACTCTGAAGAGCAGCAAGAGAAAAGCATCATAGCAACCATCGATGACGTCCTCTCTGCTCGGCCAGGGGCA TTGCCTGAAGACGCAAACCCTGGGCCCCAGACCGAAAGCAGTAAGTTTCCCTTTGGTATCCAGCAAGCCAAAAGTCACCGGAACATCAAGCTGCTGGAGG ACGAGCCCAGGAGCCGAGACGAGACTCCTCTGTGTACCATCGCGCACTGGCAGGACTCGCTGGCTAAGCGATGCATCTGTGTGTCCAATATTGTCCGTAG CTTGTCATTCGTGCCTGGCAATGATGCCGAAATGTCCAAACATCCAGGCCTGGTGCTGATCCTGGGGAAGCTGATTCTTCTTCACCACGAGCATCCAGAG AGAAAGCGAGCACCGCAGACCTATGAGAAAGAGGAGGATGAGGACAAGGGGGTGGCCTGCAGCAAAGATGAGTGGTGGTGGGACTGCCTCGAGGTCTTGA GGGATAACACGTTGGTCACGTTGGCCAACATTTCCGGGCAGCTAGACTTGTCTGCTTACACGGAAAGCATCTGCTTGCCAATTTTGGATGGCTTGCTGCA CTGGATGGTGTGCCCGTCTGCAGAGGCACAAGATCCCTTTCCAACTGTGGGACCCAACTCGGTCCTGTCGCCTCAGAGACTTGTGCTGGAGACCCTCTGT AAACTCAGTATCCAGGACAATAATGTGGACCTGATCTTGGCCACTCCTCCATTTAGTCGTCAGGAGAAATTCTATGCTACATTAGTTAGGTACGTTGGGG ATCGCAAAAACCCAGTCTGTCGAGAAATGTCCATGGCGCTTTTATCGAACCTTGCCCAAGGGGACGCACTAGCAGCAAGGGCCATAGCTGTGCAGAAAGG AAGCATTGGAAACTTGATAAGCTTCCTAGAGGATGGGGTCACGATGGCCCAGTACCAGCAGAGCCAGCACAACCTCATGCACATGCAGCCCCCGCCCCTG GAACCACCTAGCGTAGACATGATGTGCAGGGCGGCCAAGGCTTTGCTAGCCATGGCCAGAGTGGACGAAAACCGCTCGGAATTCCTTTTGCACGAGGGCC GGTTGCTGGATATCTCGATATCAGCTGTCCTGAACTCTCTGGTTGCATCTGTCATCTGTGATGTACTGTTTCAGATTGGGCAGTTATGACATAAGTGAGA AGGCAAGCATGTGTGAGTGAAGATTAGAGGGTCACATATAACTGGCTGTTTTCTGTTCTTGTTTATCCAGCGTAGGAAGAAGGAAAAGAAAATCTTTGCT CCTCTGCCCCATTCACTATTTACCAATTGGGAATTAAAGAAATAATTAATTTGAACAGTTATGAAATTAATATTTGCTGTCTGTGTGTATAAGTACATCC TTTGGGGTTTTTTTTTTCTCTTTTTTTTAACCAAAGTTGCTGTCTAGTGCATTCAAAGGTCACTTTTTGTTCTTCACAGATCTTTTTAATGTTCTTTCCC ATGTTGTATTGCATTTTTGGGGGAAGCAAATTGACTTTAAAGAAAAAAGTTGTGGCAAAAGATGCTAAGATGCGAAAATTTCACCACACTGAGTCAAAAA GGTGAAAAATTATCCATTTCCTATGCGTTTTACTCCTCAGAGAATGAAAAAAACTGCATCCCATCACCCAAAGTTCTGTGCAATAGAAATTTCTACAGAT ACAGGTATAGGGGCTCAAGGAGGTATGTCGGTCAGTAGTCAAAACTATGAAATGATACTGGTTTCTCCACAGGAATATGGTTCCATTAGGCTGGGAGCAA AAACAATGTTTTTTAAGATTGAGAATACATACCTGACAACGATCCGGAAACTGCTCCTCACCACTCCCGTCATGCCTGCTGTCGGCGTTTGACCTTCCAC GTGACAGTTCTTCACAATTCCTTTCATCATTTTTTAAATATTTTTTTTACTGCCTATGGGCTGTGATGTATATAGAAGTTGTACATTAAACATACCCTCA TTTTTTTCTTTTCTTTTTTTTTTTTTTTTTTAGTACAAAGTTTTAGTTTCTTTTTCATGATGTGGTAACTACGAAGTGATGGTAGATTTAAATAATTTTT TATTTTTATTTTATATATTTTTTCATTAGGGCCATATCTCCAAAAAAAGAAAGAAAAAATACAAAAAACAAAAACAAAAAAAAAAGAGGGTAATGTACAA GTTTCTGTATGTATAAAGTCATGCTCGATTTCAGGAGAGCAGCTGATCACAATTTGCTTCATGAATCAAGGTGTGGAAATGGTTATATATGGATTGATTT AGAAAATGGTTACCAGTACAGTCAAAAAAGAGAAAATGAAAAAAATACAACTAAAAGGAAGAAACACAACTTCAAAGATTTTTCAGTGATGAGAATCCAC ATTTGTATTTCAAGATAATGTAGTTTAAAAAAAAAAAAAAGAAAAAAACTTGATGTAAATTCCTCCTTTTCCTCTGGCTTAATGAATATCATTTATTCAG TATAAAATCTTTATATGTTCCACATGTTAAGAATAAATGTACATTAAATCTTGTTAAGCACTGTGA

refseq_ARID1B.F1 (forward primer)
refseq_ARID1B.R1 (reverse primer)
Single exon skipping

Frame 0

RPPPAPTAPRAAAPRRLSRRVEAPPRCPPPPPP PRRQRRHPLPPRRARARPWRRGCSPTTN*KPLAK PPPRRPTSSTTTTTMPTTTTTMPTTSTTTTHYS SS*TSSSSSSSSSNSSSSSSSNSNIPFPTTTAW AARAAARLSPAPTWSSRNMEAPRTVLRAARPTPR ARRC*ASRATRTTRRPRWGSRRAAATSTRAWAP WARSSRRSPCPGAAAARRPSRSLIITMAALPLR AAAPAAALGLALINMADNKAPGWG*CTPPPPPPP GPPAAWTPCRTPTKGTPTASATIIRATAGPARA AAAAAAAEEEEAAEEEEEEEEQEQEEQERELWR RRPRRRRQQQEAAAAAAMGARPRGTGC*APPGSR AAA**WAPGAAGPRASARRPPARRRGASSASPA RTSTRRGPPRPSISCSPRPAP*CGATAAATPST AAPARRRRRRRSPSPRRRRRGRRRAASRRPRAWA WARTWAPSTPLPARPGRPRNKGVTRR*APAPPD RPWADPRAAQWIQW**RDLSCMAWAVTLILSLS RAVRTQEVPMALQAHSGIQLASRVGLPGPWPECS TLSSRCHLSMDSKV*VVTASRANSHITASSRSP RTSHPRRSICRPSPSRGTSRSRTCLRKAMELDL NLLWPPENLTMKT*T*YSKKDHQVYQICLAPLMT SPRERKQL*AQQSVHPGPRAAKGIRATRRSRLS PHMRPLISPASRGAHLPLLLALL*EATSLDLAQ SLLQVSQVVRCLRSHPGASQNPVPIPP*ASHQCH RKEVLWQAHKETLRWLSMDLNRQDHPCRLILLL GARCMLESVAFSRVTQVGLTVHR*ASMDHKVTT PDPQRIVGCPVQATAAQGPVWVSVPTTRCMDKGQ ASHVVLCPWDECHQLGCRTDHFLEI*AA*PPVL LACLSREGQEWGRQCQL*TVRHRRQPQQ*CRLL RTQHKAGKAVSPA*TRVDLWLPALPTASP*TTAL A**TRRRRPTAWRPPW*TARQHLWVLQI*CLLV NPNCPCLSKQTAKKKALHSPRASQRSPAPPPLL GRRSRRCTSWGMSQRESSGSTDTSPSWKREALLS QVCLPWARSPWTCSDSTSASKRSGVWPRLIKTR SGVSWQPT*TLAPQAVQRAP*KSSIFSTCLPLS ARSNVGRSPRRKSSAPGTPKSSPSSSRHLLLTRD PCKAHRPPSQLAAIPWQRFQVT*SHLPQPPPLT AR*LQCKVEEAVQSVCTTHSQM*VIHPSRNGTP *LQTPPTSRA*ACPM*WAGCPMSPTRTPLGE*EK CLEAASPL*RKDRCPTAACRTCTTKVPPEQCLT WAWGSASSFPMEPVTTEGMNLMGSSIQAKALPR DSRRMEGTSPACTHSSRITNAIWTACTGPQPSAT RATCTTCSTAASSRRCTTSMEAPTRARTAGPSR ASTRIPTAGRGCRARGRSRHTESRLR*WAARCS RPPVRGLSRICGQHAMICLIPTRTGRALAALHRR PLTQA*TAQTI*WYPIRG*IMRASGLLTSASVS LICRPQPPCSPSHAHHSRPTRRHRHCQITSPGR PAQRPSSAPWRTACLQASLLFCRL*RCRRSCPRS PHPRSPGHHPNHPQSEGRSPFLLAQ*KHHNQS* NKGERLPPKISLLLRRGV**CPLNQVFWLRVRG LWTLLIFFCMMTALLLLSISPSCLDFSNF*SSTL ENA*LTFLEFLWNMKWETPAKKHLITTQQGRMT ASPWQTILGKRRKMLNVLMTTRKTRRMRRKTAR RQKAMKRAASL*LPRTPLQTQRRSPSKPVSSTSC Q*R*SKRTTCLLLTDLTSWGVCRSSIVAFCTGS SAGVTPPSTFRLTLRARWKFLLAGAHLPP*APQ VERKSKKAKATLKSSKRKAS*QPSMTSSLLGQGH CLKTQTLGPRPKAVSFPLVSSKPKVTGTSSCWR TSPGAETRLLCVPSRTGRTRWLSDASVCPILSV ACHSCLAMMPKCPNIQAWC*SWGS*FFFTTSIQR ESEHRRPMRKRRMRTRGWPAAKMSGGGTASRS* GITRWSRWPTFPGS*TCLLTRKASACQFWMACC TGWCARLQRHKIPFQLWDPTRSCRLRDLCWRPSV NSVSRTIMWT*SWPLLHLVVRRNSMLH*LGTLG IAKTQSVEKCPWRFYRTLPKGTH*QQGP*LCRK EALET**AS*RMGSRWPSTSRASTTSCTCSPRPW NHLA*T*CAGRPRLC*PWPEWTKTARNSFCTRA GCWISRYQLS*TLWLHLSSVMYCFRLGSYDISE KASMCE*RLEGHI*LAVFCSCLSSVGRRKRKSLL LCPIHYLPIGN*RNN*FEQL*N*YLLSVCISTS FGVFFFSFF*PKLLSSAFKGHFLFFTDLFNVLS HVVLHFWGKQIDFKEKSCGKRC*DAKISPH*VKK VKNYPFPMRFTPQRMKKTASHHPKFCAIEISTD TGIGAQGGMSVSSQNYEMILVSPQEYGSIRLGA KTMFFKIENTYLTTIRKLLLTTPVMPAVGV*PST *QFFTIPFIIF*IFFLLPMGCDVYRSCTLNIPS FFSFLFFFFF*YKVLVSFS*CGNYEVMVDLNNF LFLFYIFFH*GHISKKRKKKYKKQKQKKKRVMYK FLYV*SHARFQESS*SQFAS*IKVWKWLYMD*F RKWLPVQSKKRK*KKYN*KEETQLQRFFSDENP HLYFKIM*FKKKKKKKT*CKFLLFLWLNEYHLFS IKSLYVPHVKNKCTLNLVKHC

Frame 1

GRRRHPQRQERRLRGGSQGGWKRRRAVLLLLLL RGGSGGILFLLVGPGLGHGDGAAPQPQTENRWR SPRRAAPPAAPPPPPCPPPPPPCPPPPPPPRTTA AAKPVPAAAAAAATAAAAAAATATSHFQQQQLG RRGRRRASARPRHGAAATWRRQGQCCGRPGRPP GPAAAEQAGRRGRRAAQDGGAGGRPLRAPGLGRP GHAAAAGRRARGRRRPGGRPGV**LLWQRCPCE RRPRRPRWALL*STWRTTKPRDGDDALRLRRRR RGPRQHGPPAELPRRVPQQPVQPLSGLQPARRGR RRRRRRRRRRRQRRRRRRRRSRSRRSRSGSCGG GGRGGGGSSRRRRRRRLWGLVRGVRGAELPPAA GRRHDDGPRGRRGREPQQGGRRLGGGGLPALRRP EPAPVGGHPDPQSAAHLAQPHDAELRRQLPRVQ QPQRAAAAAVAAPVPGGGGGGGGGRPAGGRGHG LGQGHGRPVRRCQPGLGGRATKESPGDEPRHPRT DHGQIPGQPNGSNGDEETSVVWHGQ*PSFSASA EQSVPRRFLWPSRPTAVSNWHPGSDSRGHGRNA VPSAADATSVWTARCEWLLPAGPTAILQPAAAAP APPTPGAVSAVPVPAEVPAAAGHVSGRLWN*IS TSSGPRKT*P*RLELNTARKTIKFTRSVWLH** PPHGNGSNFELSSQCIRVHEQPRGSEQPGAVAFL PTCVPSSLQHPGGPISLSCWLSCRKQPVSIWPN LSCKYPR*SDASAATREPVRIQFPSRLEPVTNA TGKRFYGRHTKKPSDGSVWTSTDRTIHVASSFSW GPDACWNQ*LSAE*LKWDLRSTDEPVWTTR*LL QTPSV*WGAQCKLQRPRARYGYQCQQPDAWTRA KPAMWCCAPGTNAISWDAEQTISWKYEQHDPQFS WHVSAGRARNGAANANCEP*GTGGSRSSDAGCC ELSTKQARQFPRHEPEWTYGFQLSLQPAHEQQL *PDEHAGAALQHGARHGEQLGSICGSCRYDVSW* IQTAPASQSRRQRRRHSTAREQVKEVQLLHHYW GEDHEGVRAGE*AREKALGRPIPHLHGRERLSC LKSACRGQEAPGPVPTLRLRQRDRGFGPG**KQE VA*AGNQPKRWHLKQCSELPEKAVYSVPVCL*V QDRTWGGAPAGSLQHRGHQKAAQAPAAISC*LG ILARPTDPPVNWQQFHGRGSR*PEATYPSLHPSR PDDSNARWKKQYNQCARPILRCE*FILPETELH DSKRPLPAGHEHARCDGQDAL*AQQGPLWGNEK SAWKQRALYDARTDAQQQHAGHVQPKSLRSNV*P GHGAAPAVSLWSQLRPKA*TLWAAVSRPRPSLG TAAVWRAPARPVPTAAELQTPYGRHVRAPSQAP RGRHVQHAVQQPAAGDVQPVWRLLLGPGPQAHPG PVPVSLQQGEDAGPGADPDTRNPASDDGRPAAV VLQ*GASAEYVGSTQ*YALSLPEQAGPWRPYTG APLPRHEPHRRYDGTRSEDKS*EPVAFSRQPASA LYVVLSLHAAHHTPTTAVLPDATVTAKSHLQGA QPSVLPALPGEPHVSKQVSFSAVYEDAEGHAHG PHIPGHRATTPTTPNQKGDHLSSWLSRSITTSLE TKAKDYLQRYRYS*GVACDDVP*IRSFG*EYVG FGHY*YSSV**QHCCYFQSLPVVWISRTFSRVL *KMPD*HFWNSYGI*SGRPQPKST*SQRSKEG*Q PVLGRRFWERGGRC*MY**RRGRRGG*GGRQRE DRKR*KEQHRSDCPGRRCRPKGEAQASQ*VRQA ANKDSQKEQPVCC*PI*QVGACAGVQ*WPSALAA RRG*HHRAHSDSL*EQDGNSSSQAPTSPLKLRR *KERARRQRRL*RAAREKHHSNHR*RPLCSARG IA*RRKPWAPDRKQ*VSLWYPASQKSPEHQAAGG RAQEPRRDSSVYHRALAGLAG*AMHLCVQYCP* LVIRAWQ*CRNVQTSRPGADPGEADSSSPRASR EKASTADL*ERGG*GQGGGLQQR*VVVGLPRGLE G*HVGHVGQHFRAARLVCLHGKHLLANFGWLAA LDGVPVCRGTRSLSNCGTQLGPVASETCAGDPL *TQYPGQ*CGPDLGHSSI*SSGEILCYIS*VRWG SQKPSLSRNVHGAFIEPCPRGRTSSKGHSCAER KHWKLDKLPRGWGHDGPVPAEPAQPHAHAAPAP GTT*RRHDVQGGQGFASHGQSGRKPLGIPFARGP VAGYLDISCPELSGCICHL*CTVSDWAVMT*VR RQACVSED*RVTYNWLFSVLVYPA*EEGKENLC SSAPFTIYQLGIKEIINLNSYEINICCLCV*VHP LGFFFSLFFNQSCCLVHSKVTFCSSQIFLMFFP MLYCIFGGSKLTLKKKVVAKDAKMRKFHHTESK R*KIIHFLCVLLLRE*KKLHPITQSSVQ*KFLQI QV*GLKEVCRSVVKTMK*YWFLHRNMVPLGWEQ KQCFLRLRIHT*QRSGNCSSPLPSCLLSAFDLP RDSSSQFLSSFFKYFFYCLWAVMYIEVVH*TYPH FFLFFFFFFFSTKF*FLFHDVVTTK*W*I*IIF YFYFIYFFIRAISPKKERKNTKNKNKKKRG*CT SFCMYKVMLDFRRAADHNLLHESRCGNGYIWIDL ENGYQYSQKRENEKNTTKRKKHNFKDFSVMRIH ICISR*CSLKKKKRKKLDVNSSFSSGLMNIIYS V*NLYMFHMLRINVH*ILLSTV

Frame 2

AAAGTHSAKSGGSEAALKEGGSAAALSSSSSSS AAAAAASSSSSSGPGSAMETGLLPNHKLKTVGE APAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQ QQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLG GAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPP GPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGA LGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPAS GGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAA GAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAG GGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAA AAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQ GGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAG QNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYS SPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMG LGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPG PTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQ SSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQ YPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQP PHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQ PPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDD LPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI SPASIPGSQMPPQPPGSQSESSSHPALSQSPMP QERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSP GGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS RPPAYSGVPSASYSGPGPGMGISANNQMHGQGP SQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSS PGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAA NSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSS SLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG ESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTG EKITKVYELGNEPERKLWVDRYLTFMEERGSPV SSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNK KWRELATNLNVGTSSSAASSLKKQYIQYLFAFEC KIERGEEPPPEVFSTGDTKKQPKLQPPSPANSG SLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPH GQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSM TPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRK VPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSN LGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSG QPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRH EGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQ GQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQS SSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQA PPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAP SPASFQRSLENRMSPSKSPFLPSMKMQKVMPTV PTSQVTGPPPQPPPIRREITFPPGSVEASQPVL KQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWA LDTINILLYDDSTVATFNLSQLSGFLELLVEYF RKCLIDIFGILMEYEVGDPSQKALDHNAARKDD SQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEK TESDEKSSIALTAPDAAADPKEKPKQASKFDKL PIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQ LGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAG RKKEQEGKGDSEEQQEKSIIATIDDVLSARPGA LPEDANPGPQTESSKFPFGIQQAKSHRNIKLLE DEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRS LSFVPGNDAEMSKHPGLVLILGKLILLHHEHPE RKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVL RDNTLVTLANISGQLDLSAYTESICLPILDGLLH WMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLC KLSIQDNNVDLILATPPFSRQEKFYATLVRYVG DRKNPVCREMSMALLSNLAQGDALAARAIAVQKG SIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPL EPPSVDMMCRAAKALLAMARVDENRSEFLLHEG RLLDISISAVLNSLVASVICDVLFQIGQL*HK*E GKHV*VKIRGSHITGCFLFLFIQRRKKEKKIFA PLPHSLFTNWELKK*LI*TVMKLIFAVCVYKYI LWGFFFLFFLTKVAV*CIQRSLFVLHRSF*CSFP CCIAFLGEAN*L*RKKLWQKMLRCENFTTLSQK GEKLSISYAFYSSENEKNCIPSPKVLCNRNFYR YRYRGSRRYVGQ*SKL*NDTGFSTGIWFH*AGSK NNVF*D*EYIPDNDPETAPHHSRHACCRRLTFH VTVLHNSFHHFLNIFFTAYGL*CI*KLYIKHTL IFFFSFFFFFLVQSFSFFFMMW*LRSDGRFK*FF IFILYIFSLGPYLQKKKEKIQKTKTKKKEGNVQ VSVCIKSCSISGEQLITICFMNQGVEMVIYGLI *KMVTSTVKKEKMKKIQLKGRNTTSKIFQ**EST FVFQDNVV*KKKKEKNLM*IPPFPLA**ISFIQ YKIFICSTC*E*MYIKSC*AL*

Sequence NM_017519

CGGCCGCCGCCGGCACCCACAGCGCCAAGAGCGGCGGCTCCGAGGCGGCTCTCAAGGAGGGTGGAAGCGCCGCCGCGCTGTCCTCCTCCTCCTCCTCCTC CGCGGCGGCAGCGGCGGCATCCTCTTCCTCCTCGTCGGGCCCGGGCTCGGCCATGGAGACGGGGCTGCTCCCCAACCACAAACTGAAAACCGTTGGCGAA GCCCCCGCCGCGCCGCCCCACCAGCAGCACCACCACCACCACCATGCCCACCACCACCACCACCATGCCCACCACCTCCACCACCACCACGCACTACAGC AGCAGCTAAACCAGTTCCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAACAGCAACATCCCATTTCCAACAACAACAGCTTGGG CGGCGCGGGCGGCGGCGCGCCTCAGCCCGGCCCCGACATGGAGCAGCCGCAACATGGAGGCGCCAAGGACAGTGCTGCGGGCGGCCAGGCCGACCCCCCG GGCCCGCCGCTGCTGAGCAAGCCGGGCGACGAGGACGACGCGCCGCCCAAGATGGGGGAGCCGGCGGGCGGCCGCTACGAGCACCCGGGCTTGGGCGCCC TGGGCACGCAGCAGCCGCCGGTCGCCGTGCCCGGGGGCGGCGGCGGCCCGGCGGCCGTCCCGGAGTTTAATAATTACTATGGCAGCGCTGCCCCTGCGAG CGGCGGCCCCGGCGGCCGCGCTGGGCCTTGCTTTGATCAACATGGCGGACAACAAAGCCCCGGGATGGGGATGATGCACTCCGCCTCCGCCGCCGCCGCC GGGGCCCCCGGCAGCATGGACCCCCTGCAGAACTCCCACGAAGGGTACCCCAACAGCCAGTGCAACCATTATCCGGGCTACAGCCGGCCCGGCGCGGGCG GCGGCGGCGGCGGCGGCGGCGGAGGAGGAGGAGGCAGCGGAGGAGGAGGAGGAGGAGGAGGAGCAGGAGCAGGAGGAGCAGGAGCGGGAGCTGTGGCGGC GGCGGCCGCGGCGGCGGCGGCAGCAGCAGGAGGCGGCGGCGGCGGCGGCTATGGGGGCTCGTCCGCGGGGTACGGGGTGCTGAGCTCCCCCCGGCAGCAG GGCGGCGGCATGATGATGGGCCCCGGGGGCGGCGGGGCCGCGAGCCTCAGCAAGGCGGCCGCCGGCTCGGCGGCGGGGGGCTTCCAGCGCTTCGCCGGCC AGAACCAGCACCCGTCGGGGGCCACCCCGACCCTCAATCAGCTGCTCACCTCGCCCAGCCCCATGATGCGGAGCTACGGCGGCAGCTACCCCGAGTACAG CAGCCCCAGCGCGCCGCCGCCGCCGCCGTCGCAGCCCCAGTCCCAGGCGGCGGCGGCGGGGGCGGCGGCGGGCGGCCAGCAGGCGGCCGCGGGCATGGGC TTGGGCAAGGACATGGGCGCCCAGTACGCCGCTGCCAGCCCGGCCTGGGCGGCCGCGCAACAAAGGAGTCACCCGGCGATGAGCCCCGGCACCCCCGGAC CGACCATGGGCAGATCCCAGGGCAGCCCAATGGATCCAATGGTGATGAAGAGACCTCAGTTGTATGGCATGGGCAGTAACCCTCATTCTCAGCCTCAGCA GAGCAGTCCGTACCCAGGAGGTTCCTATGGCCCTCCAGGCCCACAGCGGTATCCAATTGGCATCCAGGGTCGGACTCCCGGGGCCATGGCCGGAATGCAG TACCCTCAGCAGCAGATGCCACCTCAGTATGGACAGCAAGGTGTGAGTGGTTACTGCCAGCAGGGCCAACAGCCATATTACAGCCAGCAGCCGCAGCCCC CGCACCTCCCACCCCAGGCGCAGTATCTGCCGTCCCAGTCCCAGCAGAGGTACCAGCCGCAGCAGGACATGTCTCAGGAAGGCTATGGAACTAGATCTCA ACCTCCTCTGGCCCCCGGAAAACCTAACCATGAAGACTTGAACTTAATACAGCAAGAAAGACCATCAAGTTTACCAGATCTGTCTGGCTCCATTGATGAC CTCCCCACGGGAACGGAAGCAACTTTGAGCTCAGCAGTCAGTGCATCCGGGTCCACGAGCAGCCAAGGGGATCAGAGCAACCCGGCGCAGTCGCCTTTCT CCCCACATGCGTCCCCTCATCTCTCCAGCATCCCGGGGGGCCCATCTCCCTCTCCTGTTGGCTCTCCTGTAGGAAGCAACCAGTCTCGATCTGGCCCAAT CTCTCCTGCAAGTATCCCAGGTAGTCAGATGCCTCCGCAGCCACCCGGGAGCCAGTCAGAATCCAGTTCCCATCCCGCCTTGAGCCAGTCACCAATGCCA CAGGAAAGAGGTTTTATGGCAGGCACACAAAGAAACCCTCAGATGGCTCAGTATGGACCTCAACAGACAGGACCATCCATGTCGCCTCATCCTTCTCCTG GGGGCCAGATGCATGCTGGAATCAGTAGCTTTCAGCAGAGTAACTCAAGTGGGACTTACGGTCCACAGATGAGCCAGTATGGACCACAAGGTAACTACTC CAGACCCCCAGCGTATAGTGGGGTGCCCAGTGCAAGCTACAGCGGCCCAGGGCCCGGTATGGGTATCAGTGCCAACAACCAGATGCATGGACAAGGGCCA AGCCAGCCATGTGGTGCTGTGCCCCTGGGACGAATGCCATCAGCTGGGATGCAGAACAGACCATTTCCTGGAAATATGAGCAGCATGACCCCCAGTTCTC CTGGCATGTCTCAGCAGGGAGGGCCAGGAATGGGGCCGCCAATGCCAACTGTGAACCGTAAGGCACAGGAGGCAGCCGCAGCAGTGATGCAGGCTGCTGC GAACTCAGCACAAAGCAGGCAAGGCAGTTTCCCCGGCATGAACCAGAGTGGACTTATGGCTTCCAGCTCTCCCTACAGCCAGCCCATGAACAACAGCTCT AGCCTGATGAACACGCAGGCGCCGCCCTACAGCATGGCGCCCGCCATGGTGAACAGCTCGGCAGCATCTGTGGGTCTTGCAGATATGATGTCTCCTGGTG AATCCAAACTGCCCCTGCCTCTCAAAGCAGACGGCAAAGAAGAAGGCACTCCACAGCCCGAGAGCAAGTCAAAGGATAGCTACAGCTCTCAGGGTATTTC TCAGCCCCCAACCCCAGGCAACCTGCCAGTCCCTTCCCCAATGTCCCCCAGCTCTGCTAGCATCTCCTCATTTCATGGAGATGAAAGTGATAGCATTAGC AGCCCAGGCTGGCCAAAGACTCCATCAAGCCCTAAGTCCAGCTCCTCCACCACTACTGGGGAGAAGATCACGAAGGTGTACGAGCTGGGGAATGAGCCAG AGAGAAAGCTCTGGGTCGACCGATACCTCACCTTCATGGAAGAGAGAGGCTCTCCTGTCTCAAGTCTGCCTGCCGTGGGCAAGAAGCCCCTGGACCTGTT CCGACTCTACGTCTGCGTCAAAGAGATCGGGGGTTTGGCCCAGGTTAATAAAAACAAGAAGTGGCGTGAGCTGGCAACCAACCTAAACGTTGGCACCTCA AGCAGTGCAGCGAGCTCCCTGAAAAAGCAGTATATTCAGTACCTGTTTGCCTTTGAGTGCAAGATCGAACGTGGGGAGGAGCCCCCGCCGGAAGTCTTCA GCACCGGGGACACCAAAAAGCAGCCCAAGCTCCAGCCGCCATCTCCTGCTAACTCGGGATCCTTGCAAGGCCCACAGACCCCCCAGTCAACTGGCAGCAA TTCCATGGCAGAGGTTCCAGGTGACCTGAAGCCACCTACCCCAGCCTCCACCCCTCACGGCCAGATGACTCCAATGCAAGGTGGAAGAAGCAGTACAATC AGTGTGCACGACCCATTCTCAGATGTGAGTGATTCATCCTTCCCGAAACGGAACTCCATGACTCCAAACGCCCCCTACCAGCAGGGCATGAGCATGCCCG ATGTGATGGGCAGGATGCCCTATGAGCCCAACAAGGACCCCTTTGGGGGAATGAGAAAAGTGCCTGGAAGCAGCGAGCCCTTTATGACGCAAGGACAGAT GCCCAACAGCAGCATGCAGGACATGTACAACCAAAGTCCCTCCGGAGCAATGTCTAACCTGGGCATGGGGCAGCGCCAGCAGTTTCCCTATGGAGCCAGT TACGACCGAAGGCATGAACCTTATGGGCAGCAGTATCCAGGCCAAGGCCCTCCCTCGGGACAGCCGCCGTATGGAGGGCACCAGCCCGGCCTGTACCCAC AGCAGCCGAATTACAAACGCCATATGGACGGCATGTACGGGCCCCCAGCCAAGCGCCACGAGGGCGACATGTACAACATGCAGTACAGCAGCCAGCAGCA GGAGATGTACAACCAGTATGGAGGCTCCTACTCGGGCCCGGACCGCAGGCCCATCCAGGGCCAGTACCCGTATCCCTACAGCAGGGAGAGGATGCAGGGC CCGGGGCAGATCCAGACACACGGAATCCCGCCTCAGATGATGGGCGGCCCGCTGCAGTCGTCCTCCAGTGAGGGGCCTCAGCAGAATATGTGGGCAGCAC GCAATGATATGCCTTATCCCTACCAGAACAGGCAGGGCCCTGGCGGCCCTACACAGGCGCCCCCTTACCCAGGCATGAACCGCACAGACGATATGATGGT ACCCGATCAGAGGATAAATCATGAGAGCCAGTGGCCTTCTCACGTCAGCCAGCGTCAGCCTTATATGTCGTCCTCAGCCTCCATGCAGCCCATCACACGC CCACCACAGCCGTCCTACCAGACGCCACCGTCACTGCCAAATCACATCTCCAGGGCGCCCAGCCCAGCGTCCTTCCAGCGCTCCCTGGAGAACCGCATGT CTCCAAGCAAGTCTCCTTTTCTGCCGTCTATGAAGATGCAGAAGGTCATGCCCACGGTCCCCACATCCCAGGTCACCGGGCCACCACCCCAACCACCCCC AATCAGAAGGGAGATCACCTTTCCTCCTGGCTCAGTAGAAGCATCACAACCAGTCTTGAAACAAAGGCGAAAGATTACCTCCAAAGATATCGTTACTCCT GAGGCGTGGCGTGTGATGATGTCCCTTAAATCAGGTCTTTTGGCTGAGAGTACGTGGGCTTTGGACACTATTAATATTCTTCTGTATGATGACAGCACTG TTGCTACTTTCAATCTCTCCCAGTTGTCTGGATTTCTCGAACTTTTAGTCGAGTACTTTAGAAAATGCCTGATTGACATTTTTGGAATTCTTATGGAATA TGAAGTGGGAGACCCCAGCCAAAAAGCACTTGATCACAACGCAGCAAGGAAGGATGACAGCCAGTCCTTGGCAGACGATTCTGGGAAAGAGGAGGAAGAT GCTGAATGTATTGATGACGACGAGGAAGACGAGGAGGATGAGGAGGAAGACAGCGAGAAGACAGAAAGCGATGAAAAGAGCAGCATCGCTCTGACTGCCC CGGACGCCGCTGCAGACCCAAAGGAGAAGCCCAAGCAAGCCAGTAAGTTCGACAAGCTGCCAATAAAGATAGTCAAAAAGAACAACCTGTTTGTTGTTGA CCGATCTGACAAGTTGGGGCGTGTGCAGGAGTTCAATAGTGGCCTTCTGCACTGGCAGCTCGGCGGGGGTGACACCACCGAGCACATTCAGACTCACTTT GAGAGCAAGATGGAAATTCCTCCTCGCAGGCGCCCACCTCCCCCCTTAAGCTCCGCAGGTAGAAAGAAAGAGCAAGAAGGCAAAGGCGACTCTGAAGAGC AGCAAGAGAAAAGCATCATAGCAACCATCGATGACGTCCTCTCTGCTCGGCCAGGGGCATTGCCTGAAGACGCAAACCCTGGGCCCCAGACCGAAAGCAG TAAGTTTCCCTTTGGTATCCAGCAAGCCAAAAGTCACCGGAACATCAAGCTGCTGGAGGACGAGCCCAGGAGCCGAGACGAGACTCCTCTGTGTACCATC GCGCACTGGCAGGACTCGCTGGCTAAGCGATGCATCTGTGTGTCCAATATTGTCCGTAGCTTGTCATTCGTGCCTGGCAATGATGCCGAAATGTCCAAAC ATCCAGGCCTGGTGCTGATCCTGGGGAAGCTGATTCTTCTTCACCACGAGCATCCAGAGAGAAAGCGAGCACCGCAGACCTATGAGAAAGAGGAGGATGA GGACAAGGGGGTGGCCTGCAGCAAAGATGAGTGGTGGTGGGACTGCCTCGAGGTCTTGAGGGATAACACGTTGGTCACGTTGGCCAACATTTCCGGGCAG CTAGACTTGTCTGCTTACACGGAAAGCATCTGCTTGCCAATTTTGGATGGCTTGCTGCACTGGATGGTGTGCCCGTCTGCAGAGGCACAAGATCCCTTTC CAACTGTGGGACCCAACTCGGTCCTGTCGCCTCAGAGACTTGTGCTGGAGACCCTCTGTAAACTCAGTATCCAGGACAATAATGTGGACCTGATCTTGGC CACTCCTCCATTTAGTCGTCAGGAGAAATTCTATGCTACATTAGTTAGGTACGTTGGGGATCGCAAAAACCCAGTCTGTCGAGAAATGTCCATGGCGCTT TTATCGAACCTTGCCCAAGGGGACGCACTAGCAGCAAGGGCCATAGCTGTGCAGAAAGGAAGCATTGGAAACTTGATAAGCTTCCTAGAGGATGGGGTCA CGATGGCCCAGTACCAGCAGAGCCAGCACAACCTCATGCACATGCAGCCCCCGCCCCTGGAACCACCTAGCGTAGACATGATGTGCAGGGCGGCCAAGGC TTTGCTAGCCATGGCCAGAGTGGACGAAAACCGCTCGGAATTCCTTTTGCACGAGGGCCGGTTGCTGGATATCTCGATATCAGCTGTCCTGAACTCTCTG GTTGCATCTGTCATCTGTGATGTACTGTTTCAGATTGGGCAGTTATGACATAAGTGAGAAGGCAAGCATGTGTGAGTGAAGATTAGAGGGTCACATATAA CTGGCTGTTTTCTGTTCTTGTTTATCCAGCGTAGGAAGAAGGAAAAGAAAATCTTTGCTCCTCTGCCCCATTCACTATTTACCAATTGGGAATTAAAGAA ATAATTAATTTGAACAGTTATGAAATTAATATTTGCTGTCTGTGTGTATAAGTACATCCTTTGGGGTTTTTTTTTTCTCTTTTTTTTAACCAAAGTTGCT GTCTAGTGCATTCAAAGGTCACTTTTTGTTCTTCACAGATCTTTTTAATGTTCTTTCCCATGTTGTATTGCATTTTTGGGGGAAGCAAATTGACTTTAAA GAAAAAAGTTGTGGCAAAAGATGCTAAGATGCGAAAATTTCACCACACTGAGTCAAAAAGGTGAAAAATTATCCATTTCCTATGCGTTTTACTCCTCAGA GAATGAAAAAAACTGCATCCCATCACCCAAAGTTCTGTGCAATAGAAATTTCTACAGATACAGGTATAGGGGCTCAAGGAGGTATGTCGGTCAGTAGTCA AAACTATGAAATGATACTGGTTTCTCCACAGGAATATGGTTCCATTAGGCTGGGAGCAAAAACAATGTTTTTTAAGATTGAGAATACATACCTGACAACG ATCCGGAAACTGCTCCTCACCACTCCCGTCATGCCTGCTGTCGGCGTTTGACCTTCCACGTGACAGTTCTTCACAATTCCTTTCATCATTTTTTAAATAT TTTTTTTACTGCCTATGGGCTGTGATGTATATAGAAGTTGTACATTAAACATACCCTCATTTTTTTCTTTTCTTTTTTTTTTTTTTTTTTAGTACAAAGT TTTAGTTTCTTTTTCATGATGTGGTAACTACGAAGTGATGGTAGATTTAAATAATTTTTTATTTTTATTTTATATATTTTTTCATTAGGGCCATATCTCC AAAAAAAGAAAGAAAAAATACAAAAAACAAAAACAAAAAAAAAAGAGGGTAATGTACAAGTTTCTGTATGTATAAAGTCATGCTCGATTTCAGGAGAGCA GCTGATCACAATTTGCTTCATGAATCAAGGTGTGGAAATGGTTATATATGGATTGATTTAGAAAATGGTTACCAGTACAGTCAAAAAAGAGAAAATGAAA AAAATACAACTAAAAGGAAGAAACACAACTTCAAAGATTTTTCAGTGATGAGAATCCACATTTGTATTTCAAGATAATGTAGTTTAAAAAAAAAAAAAAG AAAAAAACTTGATGTAAATTCCTCCTTTTCCTCTGGCTTAATGAATATCATTTATTCAGTATAAAATCTTTATATGTTCCACATGTTAAGAATAAATGTA CATTAAATCTTGTTAAGCACTGTGA

refseq_ARID1B.F1 (forward primer)
refseq_ARID1B.R1 (reverse primer)
Single exon skipping

Frame 0

RPPPAPTAPRAAAPRRLSRRVEAPPRCPPPPPP PRRQRRHPLPPRRARARPWRRGCSPTTN*KPLAK PPPRRPTSSTTTTTMPTTTTTMPTTSTTTTHYS SS*TSSSSSSSSSNSSSSSSSNSNIPFPTTTAW AARAAARLSPAPTWSSRNMEAPRTVLRAARPTPR ARRC*ASRATRTTRRPRWGSRRAAATSTRAWAP WARSSRRSPCPGAAAARRPSRSLIITMAALPLR AAAPAAALGLALINMADNKAPGWG*CTPPPPPPP GPPAAWTPCRTPTKGTPTASATIIRATAGPARA AAAAAAAEEEEAAEEEEEEEEQEQEEQERELWR RRPRRRRQQQEAAAAAAMGARPRGTGC*APPGSR AAA**WAPGAAGPRASARRPPARRRGASSASPA RTSTRRGPPRPSISCSPRPAP*CGATAAATPST AAPARRRRRRRSPSPRRRRRGRRRAASRRPRAWA WARTWAPSTPLPARPGRPRNKGVTRR*APAPPD RPWADPRAAQWIQW**RDLSCMAWAVTLILSLS RAVRTQEVPMALQAHSGIQLASRVGLPGPWPECS TLSSRCHLSMDSKV*VVTASRANSHITASSRSP RTSHPRRSICRPSPSRGTSRSRTCLRKAMELDL NLLWPPENLTMKT*T*YSKKDHQVYQICLAPLMT SPRERKQL*AQQSVHPGPRAAKGIRATRRSRLS PHMRPLISPASRGAHLPLLLALL*EATSLDLAQ SLLQVSQVVRCLRSHPGASQNPVPIPP*ASHQCH RKEVLWQAHKETLRWLSMDLNRQDHPCRLILLL GARCMLESVAFSRVTQVGLTVHR*ASMDHKVTT PDPQRIVGCPVQATAAQGPVWVSVPTTRCMDKGQ ASHVVLCPWDECHQLGCRTDHFLEI*AA*PPVL LACLSREGQEWGRQCQL*TVRHRRQPQQ*CRLL RTQHKAGKAVSPA*TRVDLWLPALPTASP*TTAL A**TRRRRPTAWRPPW*TARQHLWVLQI*CLLV NPNCPCLSKQTAKKKALHSPRASQRIATALRVF LSPQPQATCQSLPQCPPALLASPHFMEMKVIALA AQAGQRLHQALSPAPPPLLGRRSRRCTSWGMSQ RESSGSTDTSPSWKREALLSQVCLPWARSPWTC SDSTSASKRSGVWPRLIKTRSGVSWQPT*TLAPQ AVQRAP*KSSIFSTCLPLSARSNVGRSPRRKSS APGTPKSSPSSSRHLLLTRDPCKAHRPPSQLAA IPWQRFQVT*SHLPQPPPLTAR*LQCKVEEAVQS VCTTHSQM*VIHPSRNGTP*LQTPPTSRA*ACP M*WAGCPMSPTRTPLGE*EKCLEAASPL*RKDR CPTAACRTCTTKVPPEQCLTWAWGSASSFPMEPV TTEGMNLMGSSIQAKALPRDSRRMEGTSPACTH SSRITNAIWTACTGPQPSATRATCTTCSTAASS RRCTTSMEAPTRARTAGPSRASTRIPTAGRGCRA RGRSRHTESRLR*WAARCSRPPVRGLSRICGQH AMICLIPTRTGRALAALHRRPLTQA*TAQTI*W YPIRG*IMRASGLLTSASVSLICRPQPPCSPSHA HHSRPTRRHRHCQITSPGRPAQRPSSAPWRTAC LQASLLFCRL*RCRRSCPRSPHPRSPGHHPNHP QSEGRSPFLLAQ*KHHNQS*NKGERLPPKISLLL RRGV**CPLNQVFWLRVRGLWTLLIFFCMMTAL LLLSISPSCLDFSNF*SSTLENA*LTFLEFLWN MKWETPAKKHLITTQQGRMTASPWQTILGKRRKM LNVLMTTRKTRRMRRKTARRQKAMKRAASL*LP RTPLQTQRRSPSKPVSSTSCQ*R*SKRTTCLLL TDLTSWGVCRSSIVAFCTGSSAGVTPPSTFRLTL RARWKFLLAGAHLPP*APQVERKSKKAKATLKS SKRKAS*QPSMTSSLLGQGHCLKTQTLGPRPKA VSFPLVSSKPKVTGTSSCWRTSPGAETRLLCVPS RTGRTRWLSDASVCPILSVACHSCLAMMPKCPN IQAWC*SWGS*FFFTTSIQRESEHRRPMRKRRM RTRGWPAAKMSGGGTASRS*GITRWSRWPTFPGS *TCLLTRKASACQFWMACCTGWCARLQRHKIPF QLWDPTRSCRLRDLCWRPSVNSVSRTIMWT*SW PLLHLVVRRNSMLH*LGTLGIAKTQSVEKCPWRF YRTLPKGTH*QQGP*LCRKEALET**AS*RMGS RWPSTSRASTTSCTCSPRPWNHLA*T*CAGRPR LC*PWPEWTKTARNSFCTRAGCWISRYQLS*TLW LHLSSVMYCFRLGSYDISEKASMCE*RLEGHI* LAVFCSCLSSVGRRKRKSLLLCPIHYLPIGN*R NN*FEQL*N*YLLSVCISTSFGVFFFSFF*PKLL SSAFKGHFLFFTDLFNVLSHVVLHFWGKQIDFK EKSCGKRC*DAKISPH*VKKVKNYPFPMRFTPQ RMKKTASHHPKFCAIEISTDTGIGAQGGMSVSSQ NYEMILVSPQEYGSIRLGAKTMFFKIENTYLTT IRKLLLTTPVMPAVGV*PST*QFFTIPFIIF*I FFLLPMGCDVYRSCTLNIPSFFSFLFFFFF*YKV LVSFS*CGNYEVMVDLNNFLFLFYIFFH*GHIS KKRKKKYKKQKQKKKRVMYKFLYV*SHARFQES S*SQFAS*IKVWKWLYMD*FRKWLPVQSKKRK*K KYN*KEETQLQRFFSDENPHLYFKIM*FKKKKK KKT*CKFLLFLWLNEYHLFSIKSLYVPHVKNKC TLNLVKHC

Frame 1

GRRRHPQRQERRLRGGSQGGWKRRRAVLLLLLL RGGSGGILFLLVGPGLGHGDGAAPQPQTENRWR SPRRAAPPAAPPPPPCPPPPPPCPPPPPPPRTTA AAKPVPAAAAAAATAAAAAAATATSHFQQQQLG RRGRRRASARPRHGAAATWRRQGQCCGRPGRPP GPAAAEQAGRRGRRAAQDGGAGGRPLRAPGLGRP GHAAAAGRRARGRRRPGGRPGV**LLWQRCPCE RRPRRPRWALL*STWRTTKPRDGDDALRLRRRR RGPRQHGPPAELPRRVPQQPVQPLSGLQPARRGR RRRRRRRRRRRQRRRRRRRRSRSRRSRSGSCGG GGRGGGGSSRRRRRRRLWGLVRGVRGAELPPAA GRRHDDGPRGRRGREPQQGGRRLGGGGLPALRRP EPAPVGGHPDPQSAAHLAQPHDAELRRQLPRVQ QPQRAAAAAVAAPVPGGGGGGGGGRPAGGRGHG LGQGHGRPVRRCQPGLGGRATKESPGDEPRHPRT DHGQIPGQPNGSNGDEETSVVWHGQ*PSFSASA EQSVPRRFLWPSRPTAVSNWHPGSDSRGHGRNA VPSAADATSVWTARCEWLLPAGPTAILQPAAAAP APPTPGAVSAVPVPAEVPAAAGHVSGRLWN*IS TSSGPRKT*P*RLELNTARKTIKFTRSVWLH** PPHGNGSNFELSSQCIRVHEQPRGSEQPGAVAFL PTCVPSSLQHPGGPISLSCWLSCRKQPVSIWPN LSCKYPR*SDASAATREPVRIQFPSRLEPVTNA TGKRFYGRHTKKPSDGSVWTSTDRTIHVASSFSW GPDACWNQ*LSAE*LKWDLRSTDEPVWTTR*LL QTPSV*WGAQCKLQRPRARYGYQCQQPDAWTRA KPAMWCCAPGTNAISWDAEQTISWKYEQHDPQFS WHVSAGRARNGAANANCEP*GTGGSRSSDAGCC ELSTKQARQFPRHEPEWTYGFQLSLQPAHEQQL *PDEHAGAALQHGARHGEQLGSICGSCRYDVSW* IQTAPASQSRRQRRRHSTAREQVKG*LQLSGYF SAPNPRQPASPFPNVPQLC*HLLISWR*K**H* QPRLAKDSIKP*VQLLHHYWGEDHEGVRAGE*AR EKALGRPIPHLHGRERLSCLKSACRGQEAPGPV PTLRLRQRDRGFGPG**KQEVA*AGNQPKRWHL KQCSELPEKAVYSVPVCL*VQDRTWGGAPAGSLQ HRGHQKAAQAPAAISC*LGILARPTDPPVNWQQ FHGRGSR*PEATYPSLHPSRPDDSNARWKKQYN QCARPILRCE*FILPETELHDSKRPLPAGHEHAR CDGQDAL*AQQGPLWGNEKSAWKQRALYDARTD AQQQHAGHVQPKSLRSNV*PGHGAAPAVSLWSQ LRPKA*TLWAAVSRPRPSLGTAAVWRAPARPVPT AAELQTPYGRHVRAPSQAPRGRHVQHAVQQPAA GDVQPVWRLLLGPGPQAHPGPVPVSLQQGEDAG PGADPDTRNPASDDGRPAAVVLQ*GASAEYVGST Q*YALSLPEQAGPWRPYTGAPLPRHEPHRRYDG TRSEDKS*EPVAFSRQPASALYVVLSLHAAHHT PTTAVLPDATVTAKSHLQGAQPSVLPALPGEPHV SKQVSFSAVYEDAEGHAHGPHIPGHRATTPTTP NQKGDHLSSWLSRSITTSLETKAKDYLQRYRYS *GVACDDVP*IRSFG*EYVGFGHY*YSSV**QHC CYFQSLPVVWISRTFSRVL*KMPD*HFWNSYGI *SGRPQPKST*SQRSKEG*QPVLGRRFWERGGR C*MY**RRGRRGG*GGRQREDRKR*KEQHRSDCP GRRCRPKGEAQASQ*VRQAANKDSQKEQPVCC* PI*QVGACAGVQ*WPSALAARRG*HHRAHSDSL *EQDGNSSSQAPTSPLKLRR*KERARRQRRL*RA AREKHHSNHR*RPLCSARGIA*RRKPWAPDRKQ *VSLWYPASQKSPEHQAAGGRAQEPRRDSSVYH RALAGLAG*AMHLCVQYCP*LVIRAWQ*CRNVQT SRPGADPGEADSSSPRASREKASTADL*ERGG* GQGGGLQQR*VVVGLPRGLEG*HVGHVGQHFRA ARLVCLHGKHLLANFGWLAALDGVPVCRGTRSLS NCGTQLGPVASETCAGDPL*TQYPGQ*CGPDLG HSSI*SSGEILCYIS*VRWGSQKPSLSRNVHGA FIEPCPRGRTSSKGHSCAERKHWKLDKLPRGWGH DGPVPAEPAQPHAHAAPAPGTT*RRHDVQGGQG FASHGQSGRKPLGIPFARGPVAGYLDISCPELS GCICHL*CTVSDWAVMT*VRRQACVSED*RVTYN WLFSVLVYPA*EEGKENLCSSAPFTIYQLGIKE IINLNSYEINICCLCV*VHPLGFFFSLFFNQSC CLVHSKVTFCSSQIFLMFFPMLYCIFGGSKLTLK KKVVAKDAKMRKFHHTESKR*KIIHFLCVLLLR E*KKLHPITQSSVQ*KFLQIQV*GLKEVCRSVV KTMK*YWFLHRNMVPLGWEQKQCFLRLRIHT*QR SGNCSSPLPSCLLSAFDLPRDSSSQFLSSFFKY FFYCLWAVMYIEVVH*TYPHFFLFFFFFFFSTK F*FLFHDVVTTK*W*I*IIFYFYFIYFFIRAISP KKERKNTKNKNKKKRG*CTSFCMYKVMLDFRRA ADHNLLHESRCGNGYIWIDLENGYQYSQKRENE KNTTKRKKHNFKDFSVMRIHICISR*CSLKKKKR KKLDVNSSFSSGLMNIIYSV*NLYMFHMLRINV H*ILLSTV

Frame 2

AAAGTHSAKSGGSEAALKEGGSAAALSSSSSSS AAAAAASSSSSSGPGSAMETGLLPNHKLKTVGE APAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQ QQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLG GAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPP GPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGA LGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPAS GGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAA GAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAG GGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAA AAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQ GGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAG QNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYS SPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMG LGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPG PTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQ SSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQ YPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQP PHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQ PPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDD LPTGTEATLSSAVSASGSTSSQGDQSNPAQSPF SPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI SPASIPGSQMPPQPPGSQSESSSHPALSQSPMP QERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSP GGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS RPPAYSGVPSASYSGPGPGMGISANNQMHGQGP SQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSS PGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAA NSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSS SLMNTQAPPYSMAPAMVNSSAASVGLADMMSPG ESKLPLPLKADGKEEGTPQPESKSKDSYSSQGIS QPPTPGNLPVPSPMSPSSASISSFHGDESDSIS SPGWPKTPSSPKSSSSTTTGEKITKVYELGNEP ERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLF RLYVCVKEIGGLAQVNKNKKWRELATNLNVGTS SSAASSLKKQYIQYLFAFECKIERGEEPPPEVF STGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSN SMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTI SVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMP DVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQM PNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGAS YDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYP QQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQ EMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQG PGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAA RNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMV PDQRINHESQWPSHVSQRQPYMSSSASMQPITR PPQPSYQTPPSLPNHISRAPSPASFQRSLENRM SPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPP IRREITFPPGSVEASQPVLKQRRKITSKDIVTP EAWRVMMSLKSGLLAESTWALDTINILLYDDST VATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY EVGDPSQKALDHNAARKDDSQSLADDSGKEEED AECIDDDEEDEEDEEEDSEKTESDEKSSIALTA PDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVD RSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHF ESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEE QQEKSIIATIDDVLSARPGALPEDANPGPQTESS KFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTI AHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSK HPGLVLILGKLILLHHEHPERKRAPQTYEKEEDE DKGVACSKDEWWWDCLEVLRDNTLVTLANISGQ LDLSAYTESICLPILDGLLHWMVCPSAEAQDPF PTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILA TPPFSRQEKFYATLVRYVGDRKNPVCREMSMAL LSNLAQGDALAARAIAVQKGSIGNLISFLEDGV TMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKA LLAMARVDENRSEFLLHEGRLLDISISAVLNSL VASVICDVLFQIGQL*HK*EGKHV*VKIRGSHI TGCFLFLFIQRRKKEKKIFAPLPHSLFTNWELKK *LI*TVMKLIFAVCVYKYILWGFFFLFFLTKVA V*CIQRSLFVLHRSF*CSFPCCIAFLGEAN*L* RKKLWQKMLRCENFTTLSQKGEKLSISYAFYSSE NEKNCIPSPKVLCNRNFYRYRYRGSRRYVGQ*S KL*NDTGFSTGIWFH*AGSKNNVF*D*EYIPDN DPETAPHHSRHACCRRLTFHVTVLHNSFHHFLNI FFTAYGL*CI*KLYIKHTLIFFFSFFFFFLVQS FSFFFMMW*LRSDGRFK*FFIFILYIFSLGPYL QKKKEKIQKTKTKKKEGNVQVSVCIKSCSISGEQ LITICFMNQGVEMVIYGLI*KMVTSTVKKEKMK KIQLKGRNTTSKIFQ**ESTFVFQDNVV*KKKK EKNLM*IPPFPLA**ISFIQYKIFICSTC*E*MY IKSC*AL*

Sequence NM_020732

CGGCCGCCGCCGGCACCCACAGCGCCAAGAGCGGCGGCTCCGAGGCGGCTCTCAAGGAGGGTGGAAGCGCCGCCGCGCTGTCCTCCTCCTCCTCCTCCTC CGCGGCGGCAGCGGCGGCATCCTCTTCCTCCTCGTCGGGCCCGGGCTCGGCCATGGAGACGGGGCTGCTCCCCAACCACAAACTGAAAACCGTTGGCGAA GCCCCCGCCGCGCCGCCCCACCAGCAGCACCACCACCACCACCATGCCCACCACCACCACCACCATGCCCACCACCTCCACCACCACCACGCACTACAGC AGCAGCTAAACCAGTTCCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAACAGCAACATCCCATTTCCAACAACAACAGCTTGGG CGGCGCGGGCGGCGGCGCGCCTCAGCCCGGCCCCGACATGGAGCAGCCGCAACATGGAGGCGCCAAGGACAGTGCTGCGGGCGGCCAGGCCGACCCCCCG GGCCCGCCGCTGCTGAGCAAGCCGGGCGACGAGGACGACGCGCCGCCCAAGATGGGGGAGCCGGCGGGCGGCCGCTACGAGCACCCGGGCTTGGGCGCCC TGGGCACGCAGCAGCCGCCGGTCGCCGTGCCCGGGGGCGGCGGCGGCCCGGCGGCCGTCCCGGAGTTTAATAATTACTATGGCAGCGCTGCCCCTGCGAG CGGCGGCCCCGGCGGCCGCGCTGGGCCTTGCTTTGATCAACATGGCGGACAACAAAGCCCCGGGATGGGGATGATGCACTCCGCCTCCGCCGCCGCCGCC GGGGCCCCCGGCAGCATGGACCCCCTGCAGAACTCCCACGAAGGGTACCCCAACAGCCAGTGCAACCATTATCCGGGCTACAGCCGGCCCGGCGCGGGCG GCGGCGGCGGCGGCGGCGGCGGAGGAGGAGGAGGCAGCGGAGGAGGAGGAGGAGGAGGAGGAGCAGGAGCAGGAGGAGCAGGAGCGGGAGCTGTGGCGGC GGCGGCCGCGGCGGCGGCGGCAGCAGCAGGAGGCGGCGGCGGCGGCGGCTATGGGGGCTCGTCCGCGGGGTACGGGGTGCTGAGCTCCCCCCGGCAGCAG GGCGGCGGCATGATGATGGGCCCCGGGGGCGGCGGGGCCGCGAGCCTCAGCAAGGCGGCCGCCGGCTCGGCGGCGGGGGGCTTCCAGCGCTTCGCCGGCC AGAACCAGCACCCGTCGGGGGCCACCCCGACCCTCAATCAGCTGCTCACCTCGCCCAGCCCCATGATGCGGAGCTACGGCGGCAGCTACCCCGAGTACAG CAGCCCCAGCGCGCCGCCGCCGCCGCCGTCGCAGCCCCAGTCCCAGGCGGCGGCGGCGGGGGCGGCGGCGGGCGGCCAGCAGGCGGCCGCGGGCATGGGC TTGGGCAAGGACATGGGCGCCCAGTACGCCGCTGCCAGCCCGGCCTGGGCGGCCGCGCAACAAAGGAGTCACCCGGCGATGAGCCCCGGCACCCCCGGAC CGACCATGGGCAGATCCCAGGGCAGCCCAATGGATCCAATGGTGATGAAGAGACCTCAGTTGTATGGCATGGGCAGTAACCCTCATTCTCAGCCTCAGCA GAGCAGTCCGTACCCAGGAGGTTCCTATGGCCCTCCAGGCCCACAGCGGTATCCAATTGGCATCCAGGGTCGGACTCCCGGGGCCATGGCCGGAATGCAG TACCCTCAGCAGCAGGACTCTGGAGATGCCACATGGAAAGAAACATTCTGGTTGATGCCACCTCAGTATGGACAGCAAGGTGTGAGTGGTTACTGCCAGC AGGGCCAACAGCCATATTACAGCCAGCAGCCGCAGCCCCCGCACCTCCCACCCCAGGCGCAGTATCTGCCGTCCCAGTCCCAGCAGAGGTACCAGCCGCA GCAGGACATGTCTCAGGAAGGCTATGGAACTAGATCTCAACCTCCTCTGGCCCCCGGAAAACCTAACCATGAAGACTTGAACTTAATACAGCAAGAAAGA CCATCAAGTTTACCAGATCTGTCTGGCTCCATTGATGACCTCCCCACGGGAACGGAAGCAACTTTGAGCTCAGCAGTCAGTGCATCCGGGTCCACGAGCA GCCAAGGGGATCAGAGCAACCCGGCGCAGTCGCCTTTCTCCCCACATGCGTCCCCTCATCTCTCCAGCATCCCGGGGGGCCCATCTCCCTCTCCTGTTGG CTCTCCTGTAGGAAGCAACCAGTCTCGATCTGGCCCAATCTCTCCTGCAAGTATCCCAGGTAGTCAGATGCCTCCGCAGCCACCCGGGAGCCAGTCAGAA TCCAGTTCCCATCCCGCCTTGAGCCAGTCACCAATGCCACAGGAAAGAGGTTTTATGGCAGGCACACAAAGAAACCCTCAGATGGCTCAGTATGGACCTC AACAGACAGGACCATCCATGTCGCCTCATCCTTCTCCTGGGGGCCAGATGCATGCTGGAATCAGTAGCTTTCAGCAGAGTAACTCAAGTGGGACTTACGG TCCACAGATGAGCCAGTATGGACCACAAGGTAACTACTCCAGACCCCCAGCGTATAGTGGGGTGCCCAGTGCAAGCTACAGCGGCCCAGGGCCCGGTATG GGTATCAGTGCCAACAACCAGATGCATGGACAAGGGCCAAGCCAGCCATGTGGTGCTGTGCCCCTGGGACGAATGCCATCAGCTGGGATGCAGAACAGAC CATTTCCTGGAAATATGAGCAGCATGACCCCCAGTTCTCCTGGCATGTCTCAGCAGGGAGGGCCAGGAATGGGGCCGCCAATGCCAACTGTGAACCGTAA GGCACAGGAGGCAGCCGCAGCAGTGATGCAGGCTGCTGCGAACTCAGCACAAAGCAGGCAAGGCAGTTTCCCCGGCATGAACCAGAGTGGACTTATGGCT TCCAGCTCTCCCTACAGCCAGCCCATGAACAACAGCTCTAGCCTGATGAACACGCAGGCGCCGCCCTACAGCATGGCGCCCGCCATGGTGAACAGCTCGG CAGCATCTGTGGGTCTTGCAGATATGATGTCTCCTGGTGAATCCAAACTGCCCCTGCCTCTCAAAGCAGACGGCAAAGAAGAAGGCACTCCACAGCCCGA GAGCAAGTCAAAGAAGTCCAGCTCCTCCACCACTACTGGGGAGAAGATCACGAAGGTGTACGAGCTGGGGAATGAGCCAGAGAGAAAGCTCTGGGTCGAC CGATACCTCACCTTCATGGAAGAGAGAGGCTCTCCTGTCTCAAGTCTGCCTGCCGTGGGCAAGAAGCCCCTGGACCTGTTCCGACTCTACGTCTGCGTCA AAGAGATCGGGGGTTTGGCCCAGGTTAATAAAAACAAGAAGTGGCGTGAGCTGGCAACCAACCTAAACGTTGGCACCTCAAGCAGTGCAGCGAGCTCCCT GAAAAAGCAGTATATTCAGTACCTGTTTGCCTTTGAGTGCAAGATCGAACGTGGGGAGGAGCCCCCGCCGGAAGTCTTCAGCACCGGGGACACCAAAAAG CAGCCCAAGCTCCAGCCGCCATCTCCTGCTAACTCGGGATCCTTGCAAGGCCCACAGACCCCCCAGTCAACTGGCAGCAATTCCATGGCAGAGGTTCCAG GTGACCTGAAGCCACCTACCCCAGCCTCCACCCCTCACGGCCAGATGACTCCAATGCAAGGTGGAAGAAGCAGTACAATCAGTGTGCACGACCCATTCTC AGATGTGAGTGATTCATCCTTCCCGAAACGGAACTCCATGACTCCAAACGCCCCCTACCAGCAGGGCATGAGCATGCCCGATGTGATGGGCAGGATGCCC TATGAGCCCAACAAGGACCCCTTTGGGGGAATGAGAAAAGTGCCTGGAAGCAGCGAGCCCTTTATGACGCAAGGACAGATGCCCAACAGCAGCATGCAGG ACATGTACAACCAAAGTCCCTCCGGAGCAATGTCTAACCTGGGCATGGGGCAGCGCCAGCAGTTTCCCTATGGAGCCAGTTACGACCGAAGGCATGAACC TTATGGGCAGCAGTATCCAGGCCAAGGCCCTCCCTCGGGACAGCCGCCGTATGGAGGGCACCAGCCCGGCCTGTACCCACAGCAGCCGAATTACAAACGC CATATGGACGGCATGTACGGGCCCCCAGCCAAGCGCCACGAGGGCGACATGTACAACATGCAGTACAGCAGCCAGCAGCAGGAGATGTACAACCAGTATG GAGGCTCCTACTCGGGCCCGGACCGCAGGCCCATCCAGGGCCAGTACCCGTATCCCTACAGCAGGGAGAGGATGCAGGGCCCGGGGCAGATCCAGACACA CGGAATCCCGCCTCAGATGATGGGCGGCCCGCTGCAGTCGTCCTCCAGTGAGGGGCCTCAGCAGAATATGTGGGCAGCACGCAATGATATGCCTTATCCC TACCAGAACAGGCAGGGCCCTGGCGGCCCTACACAGGCGCCCCCTTACCCAGGCATGAACCGCACAGACGATATGATGGTACCCGATCAGAGGATAAATC ATGAGAGCCAGTGGCCTTCTCACGTCAGCCAGCGTCAGCCTTATATGTCGTCCTCAGCCTCCATGCAGCCCATCACACGCCCACCACAGCCGTCCTACCA GACGCCACCGTCACTGCCAAATCACATCTCCAGGGCGCCCAGCCCAGCGTCCTTCCAGCGCTCCCTGGAGAACCGCATGTCTCCAAGCAAGTCTCCTTTT CTGCCGTCTATGAAGATGCAGAAGGTCATGCCCACGGTCCCCACATCCCAGGTCACCGGGCCACCACCCCAACCACCCCCAATCAGAAGGGAGATCACCT TTCCTCCTGGCTCAGTAGAAGCATCACAACCAGTCTTGAAACAAAGGCGAAAGATTACCTCCAAAGATATCGTTACTCCTGAGGCGTGGCGTGTGATGAT GTCCCTTAAATCAGGTCTTTTGGCTGAGAGTACGTGGGCTTTGGACACTATTAATATTCTTCTGTATGATGACAGCACTGTTGCTACTTTCAATCTCTCC CAGTTGTCTGGATTTCTCGAACTTTTAGTCGAGTACTTTAGAAAATGCCTGATTGACATTTTTGGAATTCTTATGGAATATGAAGTGGGAGACCCCAGCC AAAAAGCACTTGATCACAACGCAGCAAGGAAGGATGACAGCCAGTCCTTGGCAGACGATTCTGGGAAAGAGGAGGAAGATGCTGAATGTATTGATGACGA CGAGGAAGACGAGGAGGATGAGGAGGAAGACAGCGAGAAGACAGAAAGCGATGAAAAGAGCAGCATCGCTCTGACTGCCCCGGACGCCGCTGCAGACCCA AAGGAGAAGCCCAAGCAAGCCAGTAAGTTCGACAAGCTGCCAATAAAGATAGTCAAAAAGAACAACCTGTTTGTTGTTGACCGATCTGACAAGTTGGGGC GTGTGCAGGAGTTCAATAGTGGCCTTCTGCACTGGCAGCTCGGCGGGGGTGACACCACCGAGCACATTCAGACTCACTTTGAGAGCAAGATGGAAATTCC TCCTCGCAGGCGCCCACCTCCCCCCTTAAGCTCCGCAGGTAGAAAGAAAGAGCAAGAAGGCAAAGGCGACTCTGAAGAGCAGCAAGAGAAAAGCATCATA GCAACCATCGATGACGTCCTCTCTGCTCGGCCAGGGGCATTGCCTGAAGACGCAAACCCTGGGCCCCAGACCGAAAGCAGTAAGTTTCCCTTTGGTATCC AGCAAGCCAAAAGTCACCGGAACATCAAGCTGCTGGAGGACGAGCCCAGGAGCCGAGACGAGACTCCTCTGTGTACCATCGCGCACTGGCAGGACTCGCT GGCTAAGCGATGCATCTGTGTGTCCAATATTGTCCGTAGCTTGTCATTCGTGCCTGGCAATGATGCCGAAATGTCCAAACATCCAGGCCTGGTGCTGATC CTGGGGAAGCTGATTCTTCTTCACCACGAGCATCCAGAGAGAAAGCGAGCACCGCAGACCTATGAGAAAGAGGAGGATGAGGACAAGGGGGTGGCCTGCA GCAAAGATGAGTGGTGGTGGGACTGCCTCGAGGTCTTGAGGGATAACACGTTGGTCACGTTGGCCAACATTTCCGGGCAGCTAGACTTGTCTGCTTACAC GGAAAGCATCTGCTTGCCAATTTTGGATGGCTTGCTGCACTGGATGGTGTGCCCGTCTGCAGAGGCACAAGATCCCTTTCCAACTGTGGGACCCAACTCG GTCCTGTCGCCTCAGAGACTTGTGCTGGAGACCCTCTGTAAACTCAGTATCCAGGACAATAATGTGGACCTGATCTTGGCCACTCCTCCATTTAGTCGTC AGGAGAAATTCTATGCTACATTAGTTAGGTACGTTGGGGATCGCAAAAACCCAGTCTGTCGAGAAATGTCCATGGCGCTTTTATCGAACCTTGCCCAAGG GGACGCACTAGCAGCAAGGGCCATAGCTGTGCAGAAAGGAAGCATTGGAAACTTGATAAGCTTCCTAGAGGATGGGGTCACGATGGCCCAGTACCAGCAG AGCCAGCACAACCTCATGCACATGCAGCCCCCGCCCCTGGAACCACCTAGCGTAGACATGATGTGCAGGGCGGCCAAGGCTTTGCTAGCCATGGCCAGAG TGGACGAAAACCGCTCGGAATTCCTTTTGCACGAGGGCCGGTTGCTGGATATCTCGATATCAGCTGTCCTGAACTCTCTGGTTGCATCTGTCATCTGTGA TGTACTGTTTCAGATTGGGCAGTTATGACATAAGTGAGAAGGCAAGCATGTGTGAGTGAAGATTAGAGGGTCACATATAACTGGCTGTTTTCTGTTCTTG TTTATCCAGCGTAGGAAGAAGGAAAAGAAAATCTTTGCTCCTCTGCCCCATTCACTATTTACCAATTGGGAATTAAAGAAATAATTAATTTGAACAGTTA TGAAATTAATATTTGCTGTCTGTGTGTATAAGTACATCCTTTGGGGTTTTTTTTTTCTCTTTTTTTTAACCAAAGTTGCTGTCTAGTGCATTCAAAGGTC ACTTTTTGTTCTTCACAGATCTTTTTAATGTTCTTTCCCATGTTGTATTGCATTTTTGGGGGAAGCAAATTGACTTTAAAGAAAAAAGTTGTGGCAAAAG ATGCTAAGATGCGAAAATTTCACCACACTGAGTCAAAAAGGTGAAAAATTATCCATTTCCTATGCGTTTTACTCCTCAGAGAATGAAAAAAACTGCATCC CATCACCCAAAGTTCTGTGCAATAGAAATTTCTACAGATACAGGTATAGGGGCTCAAGGAGGTATGTCGGTCAGTAGTCAAAACTATGAAATGATACTGG TTTCTCCACAGGAATATGGTTCCATTAGGCTGGGAGCAAAAACAATGTTTTTTAAGATTGAGAATACATACCTGACAACGATCCGGAAACTGCTCCTCAC CACTCCCGTCATGCCTGCTGTCGGCGTTTGACCTTCCACGTGACAGTTCTTCACAATTCCTTTCATCATTTTTTAAATATTTTTTTTACTGCCTATGGGC TGTGATGTATATAGAAGTTGTACATTAAACATACCCTCATTTTTTTCTTTTCTTTTTTTTTTTTTTTTTTAGTACAAAGTTTTAGTTTCTTTTTCATGAT GTGGTAACTACGAAGTGATGGTAGATTTAAATAATTTTTTATTTTTATTTTATATATTTTTTCATTAGGGCCATATCTCCAAAAAAAGAAAGAAAAAATA CAAAAAACAAAAACAAAAAAAAAAGAGGGTAATGTACAAGTTTCTGTATGTATAAAGTCATGCTCGATTTCAGGAGAGCAGCTGATCACAATTTGCTTCA TGAATCAAGGTGTGGAAATGGTTATATATGGATTGATTTAGAAAATGGTTACCAGTACAGTCAAAAAAGAGAAAATGAAAAAAATACAACTAAAAGGAAG AAACACAACTTCAAAGATTTTTCAGTGATGAGAATCCACATTTGTATTTCAAGATAATGTAGTTTAAAAAAAAAAAAAAGAAAAAAACTTGATGTAAATT CCTCCTTTTCCTCTGGCTTAATGAATATCATTTATTCAGTATAAAATCTTTATATGTTCCACATGTTAAGAATAAATGTACATTAAATCTTGTTAAGCAC TGTGA

refseq_ARID1B.F1 (forward primer)
refseq_ARID1B.R1 (reverse primer)
Single exon skipping

Frame 0

RPPPAPTAPRAAAPRRLSRRVEAPPRCPPPPPP PRRQRRHPLPPRRARARPWRRGCSPTTN*KPLAK PPPRRPTSSTTTTTMPTTTTTMPTTSTTTTHYS SS*TSSSSSSSSSNSSSSSSSNSNIPFPTTTAW AARAAARLSPAPTWSSRNMEAPRTVLRAARPTPR ARRC*ASRATRTTRRPRWGSRRAAATSTRAWAP WARSSRRSPCPGAAAARRPSRSLIITMAALPLR AAAPAAALGLALINMADNKAPGWG*CTPPPPPPP GPPAAWTPCRTPTKGTPTASATIIRATAGPARA AAAAAAAEEEEAAEEEEEEEEQEQEEQERELWR RRPRRRRQQQEAAAAAAMGARPRGTGC*APPGSR AAA**WAPGAAGPRASARRPPARRRGASSASPA RTSTRRGPPRPSISCSPRPAP*CGATAAATPST AAPARRRRRRRSPSPRRRRRGRRRAASRRPRAWA WARTWAPSTPLPARPGRPRNKGVTRR*APAPPD RPWADPRAAQWIQW**RDLSCMAWAVTLILSLS RAVRTQEVPMALQAHSGIQLASRVGLPGPWPECS TLSSRTLEMPHGKKHSG*CHLSMDSKV*VVTAS RANSHITASSRSPRTSHPRRSICRPSPSRGTSR SRTCLRKAMELDLNLLWPPENLTMKT*T*YSKKD HQVYQICLAPLMTSPRERKQL*AQQSVHPGPRA AKGIRATRRSRLSPHMRPLISPASRGAHLPLLL ALL*EATSLDLAQSLLQVSQVVRCLRSHPGASQN PVPIPP*ASHQCHRKEVLWQAHKETLRWLSMDL NRQDHPCRLILLLGARCMLESVAFSRVTQVGLT VHR*ASMDHKVTTPDPQRIVGCPVQATAAQGPVW VSVPTTRCMDKGQASHVVLCPWDECHQLGCRTD HFLEI*AA*PPVLLACLSREGQEWGRQCQL*TV RHRRQPQQ*CRLLRTQHKAGKAVSPA*TRVDLWL PALPTASP*TTALA**TRRRRPTAWRPPW*TAR QHLWVLQI*CLLVNPNCPCLSKQTAKKKALHSP RASQRSPAPPPLLGRRSRRCTSWGMSQRESSGST DTSPSWKREALLSQVCLPWARSPWTCSDSTSAS KRSGVWPRLIKTRSGVSWQPT*TLAPQAVQRAP *KSSIFSTCLPLSARSNVGRSPRRKSSAPGTPKS SPSSSRHLLLTRDPCKAHRPPSQLAAIPWQRFQ VT*SHLPQPPPLTAR*LQCKVEEAVQSVCTTHS QM*VIHPSRNGTP*LQTPPTSRA*ACPM*WAGCP MSPTRTPLGE*EKCLEAASPL*RKDRCPTAACR TCTTKVPPEQCLTWAWGSASSFPMEPVTTEGMN LMGSSIQAKALPRDSRRMEGTSPACTHSSRITNA IWTACTGPQPSATRATCTTCSTAASSRRCTTSM EAPTRARTAGPSRASTRIPTAGRGCRARGRSRH TESRLR*WAARCSRPPVRGLSRICGQHAMICLIP TRTGRALAALHRRPLTQA*TAQTI*WYPIRG*I MRASGLLTSASVSLICRPQPPCSPSHAHHSRPT RRHRHCQITSPGRPAQRPSSAPWRTACLQASLLF CRL*RCRRSCPRSPHPRSPGHHPNHPQSEGRSP FLLAQ*KHHNQS*NKGERLPPKISLLLRRGV** CPLNQVFWLRVRGLWTLLIFFCMMTALLLLSISP SCLDFSNF*SSTLENA*LTFLEFLWNMKWETPA KKHLITTQQGRMTASPWQTILGKRRKMLNVLMT TRKTRRMRRKTARRQKAMKRAASL*LPRTPLQTQ RRSPSKPVSSTSCQ*R*SKRTTCLLLTDLTSWG VCRSSIVAFCTGSSAGVTPPSTFRLTLRARWKF LLAGAHLPP*APQVERKSKKAKATLKSSKRKAS* QPSMTSSLLGQGHCLKTQTLGPRPKAVSFPLVS SKPKVTGTSSCWRTSPGAETRLLCVPSRTGRTR WLSDASVCPILSVACHSCLAMMPKCPNIQAWC*S WGS*FFFTTSIQRESEHRRPMRKRRMRTRGWPA AKMSGGGTASRS*GITRWSRWPTFPGS*TCLLT RKASACQFWMACCTGWCARLQRHKIPFQLWDPTR SCRLRDLCWRPSVNSVSRTIMWT*SWPLLHLVV RRNSMLH*LGTLGIAKTQSVEKCPWRFYRTLPK GTH*QQGP*LCRKEALET**AS*RMGSRWPSTSR ASTTSCTCSPRPWNHLA*T*CAGRPRLC*PWPE WTKTARNSFCTRAGCWISRYQLS*TLWLHLSSV MYCFRLGSYDISEKASMCE*RLEGHI*LAVFCSC LSSVGRRKRKSLLLCPIHYLPIGN*RNN*FEQL *N*YLLSVCISTSFGVFFFSFF*PKLLSSAFKG HFLFFTDLFNVLSHVVLHFWGKQIDFKEKSCGKR C*DAKISPH*VKKVKNYPFPMRFTPQRMKKTAS HHPKFCAIEISTDTGIGAQGGMSVSSQNYEMIL VSPQEYGSIRLGAKTMFFKIENTYLTTIRKLLLT TPVMPAVGV*PST*QFFTIPFIIF*IFFLLPMG CDVYRSCTLNIPSFFSFLFFFFF*YKVLVSFS* CGNYEVMVDLNNFLFLFYIFFH*GHISKKRKKKY KKQKQKKKRVMYKFLYV*SHARFQESS*SQFAS *IKVWKWLYMD*FRKWLPVQSKKRK*KKYN*KE ETQLQRFFSDENPHLYFKIM*FKKKKKKKT*CKF LLFLWLNEYHLFSIKSLYVPHVKNKCTLNLVKH C

Frame 1

GRRRHPQRQERRLRGGSQGGWKRRRAVLLLLLL RGGSGGILFLLVGPGLGHGDGAAPQPQTENRWR SPRRAAPPAAPPPPPCPPPPPPCPPPPPPPRTTA AAKPVPAAAAAAATAAAAAAATATSHFQQQQLG RRGRRRASARPRHGAAATWRRQGQCCGRPGRPP GPAAAEQAGRRGRRAAQDGGAGGRPLRAPGLGRP GHAAAAGRRARGRRRPGGRPGV**LLWQRCPCE RRPRRPRWALL*STWRTTKPRDGDDALRLRRRR RGPRQHGPPAELPRRVPQQPVQPLSGLQPARRGR RRRRRRRRRRRQRRRRRRRRSRSRRSRSGSCGG GGRGGGGSSRRRRRRRLWGLVRGVRGAELPPAA GRRHDDGPRGRRGREPQQGGRRLGGGGLPALRRP EPAPVGGHPDPQSAAHLAQPHDAELRRQLPRVQ QPQRAAAAAVAAPVPGGGGGGGGGRPAGGRGHG LGQGHGRPVRRCQPGLGGRATKESPGDEPRHPRT DHGQIPGQPNGSNGDEETSVVWHGQ*PSFSASA EQSVPRRFLWPSRPTAVSNWHPGSDSRGHGRNA VPSAAGLWRCHMERNILVDATSVWTARCEWLLPA GPTAILQPAAAAPAPPTPGAVSAVPVPAEVPAA AGHVSGRLWN*ISTSSGPRKT*P*RLELNTARK TIKFTRSVWLH**PPHGNGSNFELSSQCIRVHEQ PRGSEQPGAVAFLPTCVPSSLQHPGGPISLSCW LSCRKQPVSIWPNLSCKYPR*SDASAATREPVR IQFPSRLEPVTNATGKRFYGRHTKKPSDGSVWTS TDRTIHVASSFSWGPDACWNQ*LSAE*LKWDLR STDEPVWTTR*LLQTPSV*WGAQCKLQRPRARY GYQCQQPDAWTRAKPAMWCCAPGTNAISWDAEQT ISWKYEQHDPQFSWHVSAGRARNGAANANCEP* GTGGSRSSDAGCCELSTKQARQFPRHEPEWTYG FQLSLQPAHEQQL*PDEHAGAALQHGARHGEQLG SICGSCRYDVSW*IQTAPASQSRRQRRRHSTAR EQVKEVQLLHHYWGEDHEGVRAGE*AREKALGR PIPHLHGRERLSCLKSACRGQEAPGPVPTLRLRQ RDRGFGPG**KQEVA*AGNQPKRWHLKQCSELP EKAVYSVPVCL*VQDRTWGGAPAGSLQHRGHQK AAQAPAAISC*LGILARPTDPPVNWQQFHGRGSR *PEATYPSLHPSRPDDSNARWKKQYNQCARPIL RCE*FILPETELHDSKRPLPAGHEHARCDGQDA L*AQQGPLWGNEKSAWKQRALYDARTDAQQQHAG HVQPKSLRSNV*PGHGAAPAVSLWSQLRPKA*T LWAAVSRPRPSLGTAAVWRAPARPVPTAAELQT PYGRHVRAPSQAPRGRHVQHAVQQPAAGDVQPVW RLLLGPGPQAHPGPVPVSLQQGEDAGPGADPDT RNPASDDGRPAAVVLQ*GASAEYVGSTQ*YALS LPEQAGPWRPYTGAPLPRHEPHRRYDGTRSEDKS *EPVAFSRQPASALYVVLSLHAAHHTPTTAVLP DATVTAKSHLQGAQPSVLPALPGEPHVSKQVSF SAVYEDAEGHAHGPHIPGHRATTPTTPNQKGDHL SSWLSRSITTSLETKAKDYLQRYRYS*GVACDD VP*IRSFG*EYVGFGHY*YSSV**QHCCYFQSL PVVWISRTFSRVL*KMPD*HFWNSYGI*SGRPQP KST*SQRSKEG*QPVLGRRFWERGGRC*MY**R RGRRGG*GGRQREDRKR*KEQHRSDCPGRRCRP KGEAQASQ*VRQAANKDSQKEQPVCC*PI*QVGA CAGVQ*WPSALAARRG*HHRAHSDSL*EQDGNS SSQAPTSPLKLRR*KERARRQRRL*RAAREKHH SNHR*RPLCSARGIA*RRKPWAPDRKQ*VSLWYP ASQKSPEHQAAGGRAQEPRRDSSVYHRALAGLA G*AMHLCVQYCP*LVIRAWQ*CRNVQTSRPGAD PGEADSSSPRASREKASTADL*ERGG*GQGGGLQ QR*VVVGLPRGLEG*HVGHVGQHFRAARLVCLH GKHLLANFGWLAALDGVPVCRGTRSLSNCGTQL GPVASETCAGDPL*TQYPGQ*CGPDLGHSSI*SS GEILCYIS*VRWGSQKPSLSRNVHGAFIEPCPR GRTSSKGHSCAERKHWKLDKLPRGWGHDGPVPA EPAQPHAHAAPAPGTT*RRHDVQGGQGFASHGQS GRKPLGIPFARGPVAGYLDISCPELSGCICHL* CTVSDWAVMT*VRRQACVSED*RVTYNWLFSVL VYPA*EEGKENLCSSAPFTIYQLGIKEIINLNSY EINICCLCV*VHPLGFFFSLFFNQSCCLVHSKV TFCSSQIFLMFFPMLYCIFGGSKLTLKKKVVAK DAKMRKFHHTESKR*KIIHFLCVLLLRE*KKLHP ITQSSVQ*KFLQIQV*GLKEVCRSVVKTMK*YW FLHRNMVPLGWEQKQCFLRLRIHT*QRSGNCSS PLPSCLLSAFDLPRDSSSQFLSSFFKYFFYCLWA VMYIEVVH*TYPHFFLFFFFFFFSTKF*FLFHD VVTTK*W*I*IIFYFYFIYFFIRAISPKKERKN TKNKNKKKRG*CTSFCMYKVMLDFRRAADHNLLH ESRCGNGYIWIDLENGYQYSQKRENEKNTTKRK KHNFKDFSVMRIHICISR*CSLKKKKRKKLDVN SSFSSGLMNIIYSV*NLYMFHMLRINVH*ILLST V

Frame 2

AAAGTHSAKSGGSEAALKEGGSAAALSSSSSSS AAAAAASSSSSSGPGSAMETGLLPNHKLKTVGE APAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQ QQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLG GAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPP GPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGA LGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPAS GGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAA GAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAG GGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAA AAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQ GGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAG QNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYS SPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMG LGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPG PTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQ SSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQ YPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQ QGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQ QDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQER PSSLPDLSGSIDDLPTGTEATLSSAVSASGSTS SQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVG SPVGSNQSRSGPISPASIPGSQMPPQPPGSQSE SSSHPALSQSPMPQERGFMAGTQRNPQMAQYGP QQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYG PQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGM GISANNQMHGQGPSQPCGAVPLGRMPSAGMQNR PFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRK AQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMA SSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSS AASVGLADMMSPGESKLPLPLKADGKEEGTPQPE SKSKKSSSSTTTGEKITKVYELGNEPERKLWVD RYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCV KEIGGLAQVNKNKKWRELATNLNVGTSSSAASSL KKQYIQYLFAFECKIERGEEPPPEVFSTGDTKK QPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVP GDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFS DVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMP YEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQ DMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKR HMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQY GGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTH GIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYP YQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRIN HESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQ TPPSLPNHISRAPSPASFQRSLENRMSPSKSPF LPSMKMQKVMPTVPTSQVTGPPPQPPPIRREIT FPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMM SLKSGLLAESTWALDTINILLYDDSTVATFNLS QLSGFLELLVEYFRKCLIDIFGILMEYEVGDPS QKALDHNAARKDDSQSLADDSGKEEEDAECIDDD EEDEEDEEEDSEKTESDEKSSIALTAPDAAADP KEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLG RVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIP PRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSII ATIDDVLSARPGALPEDANPGPQTESSKFPFGI QQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSL AKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLI LGKLILLHHEHPERKRAPQTYEKEEDEDKGVAC SKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYT ESICLPILDGLLHWMVCPSAEAQDPFPTVGPNS VLSPQRLVLETLCKLSIQDNNVDLILATPPFSR QEKFYATLVRYVGDRKNPVCREMSMALLSNLAQG DALAARAIAVQKGSIGNLISFLEDGVTMAQYQQ SQHNLMHMQPPPLEPPSVDMMCRAAKALLAMAR VDENRSEFLLHEGRLLDISISAVLNSLVASVICD VLFQIGQL*HK*EGKHV*VKIRGSHITGCFLFL FIQRRKKEKKIFAPLPHSLFTNWELKK*LI*TV MKLIFAVCVYKYILWGFFFLFFLTKVAV*CIQRS LFVLHRSF*CSFPCCIAFLGEAN*L*RKKLWQK MLRCENFTTLSQKGEKLSISYAFYSSENEKNCI PSPKVLCNRNFYRYRYRGSRRYVGQ*SKL*NDTG FSTGIWFH*AGSKNNVF*D*EYIPDNDPETAPH HSRHACCRRLTFHVTVLHNSFHHFLNIFFTAYG L*CI*KLYIKHTLIFFFSFFFFFLVQSFSFFFMM W*LRSDGRFK*FFIFILYIFSLGPYLQKKKEKI QKTKTKKKEGNVQVSVCIKSCSISGEQLITICF MNQGVEMVIYGLI*KMVTSTVKKEKMKKIQLKGR NTTSKIFQ**ESTFVFQDNVV*KKKKEKNLM*I PPFPLA**ISFIQYKIFICSTC*E*MYIKSC*A L*