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Sequences

Sequence NM_014784

AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAATTGTCTTTCA
GAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAAAGGAGAGAATATTTTCAGAG
ATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGATTTTTATTTTATTTTTTTTTTTGGTGCAAT
TGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGG
AGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATC
CTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCA
ACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTT
TTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTC
TTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT
CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCA
AAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTAAGTAGCCTGTCTTCTCTGGGAGAT
TCTGCACCAGAGCGCAAGTCCCCTTCCCACCATCGCCAGCCTTCGGATGCCTCTGAGACAACAGGTCTCGTTCAACGCTGTGTCATTATCCAAAAGGACC
AGCATGGCTTCGGCTTCACAGTCAGTGGGGATCGCATTGTTCTGGTGCAGTCTGTGCGGCCTGGAGGTGCAGCCATGAAGGCCGGTGTGAAAGAGGGCGA
CCGGATCATCAAAGTCAACGGCACCATGGTGACCAATAGCTCACACCTGGAAGTGGTAAAGCTGATCAAATCTGGCGCCTATGTCGCACTCACCCTCCTG
GGCTCTTCACCTTCATCCATGGGCATCTCTGGGCTCCAGCAGGACCCATCCCCAGCAGGAGCTCCCCGAATCACGTCAGTGATCCCCTCACCACCACCTC
CTCCACCTCTACCACCTCCACAACGCATCACAGGACCCAAACCTCTGCAGGATCCCGAAGTTCAAAAACATGCCACCCAGATCCTCAGGAATATGCTGAG
GCAGGAAGAAAAAGAATTACAGGACATACTTCCACTATATGGTGACACCAGCCAGAGACCATCAGAAGGCCGGCTCTCTCTGGATTCCCAGGAGGGGGAC
AGTGGCTTGGACTCTGGGACAGAACGCTTTCCTTCCCTCAGTGAGTCATTGATGAATCGGAACTCGGTACTGTCAGACCCTGGGCTAGACAGTCCTCGAA
CCTCCCCTGTGATCATGGCCAGGGTGGCCCAGCACCACAGGCGGCAGGGCTCGGATGCAGCAGTCCCCTCAACCGGTGACCAGGGTGTAGATCAAAGCCC
AAAGCCTTTAATTATTGGCCCAGAGGAAGACTATGACCCGGGTTATTTCAACAACGAGAGCGACATCATATTCCAGGATCTGGAGAAACTGAAGTCTCGG
CCAGCTCACCTGGGGGTTTTTCTACGTTACATCTTCTCTCAGGCGGACCCCAGTCCACTGCTTTTTTACCTGTGTGCAGAAGTTTATCAGCAGGCAAGCC
CCAAGGATTCCCGAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCTGAGATGCTACAGGCTGAAAT
TGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAGAGCAGATCCACGACTACAGA
ACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCGCCAAGTGGCTGAGAAGCAGC
TGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATGAGCCATGCTGGGATCCGTCT
TCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTAAGACCAAGAAGAGCAGCAAT
TCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGGAAGCCCAAAAGCTCTTCTCAAAGCACATTTCATATTC
CCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCCCCAGAACCTGGGACACAACG
ACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAAGCCTCAAGGGCCGGGAAGAG
ATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCGCCTGCACCAGTCAGCCTCGT
CCTCTACCTCCAGCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATTGAGTCCCCCAGTTTGGGGTT
CTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCCAAAATTGGCAGCATACAGTG
GGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGCTTCCCACCTGCGCACACTCC
GGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCGAACCTGCCTGAACTCATAGA
GATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGCTGGCCCGGTTTGATGGCCCT
GCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAGCTAATCAAGACCAAGCAACGCAAGGAGAGTCGATTCC
AGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAGCGGCTCACCAAGTACCCGCT
GCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCCGGGAGATTCTCAAGTATGTG
AATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAGGGCCAGCAACCCCCTGGCAG
CAGAGTTCAAGAGCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAGACCTTGGACCTCCACGTGCT
GCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGGGCTCCTCAGACAGCAAGCAG
ACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTGCACCTCCAAGCTGGGCCCAC
CCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAATGCCACCAGGCACCCCGGAGC
TGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAACTGGATGACTCAGACGTGTTC
CATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGGAAGCACCAGGTCCTGCTAGAGGACCCTGAGCAGGAGG
GCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACAAGGAACCCCATCCACTTGGC
CTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGTGGAGCCTGCTGCCAGGTCAC
ACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCCCTGGGACCCAGGCTCCCCAG
GGCAAGCACCCCCTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATGGGTCTCTGTTCTCTGGAACA
CCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCACAGAGGCAGCAGGAGGTTAC
AAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCCACCTGAAGTGGAAGGCGGAA
CAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCCATGAGCCCCCCTCAGCCTGA
CAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTCCTCCAAGCCTGGCCCTCAGG
GACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGATATGGAGCTGGCCCACAGAGAGCTGCTCAAGTCCCTTG
GGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCACCTCCCGCTAAGGAGCCCCT
AGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAGCAGACGCAGCCGCGTCACCA
GGACCATAACCGTACAAACCACCAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGGTAGGGGGGATCCCAACACTC
CTCCCTGTGGAGGAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTCAAGTCGGAGTCAGGTTTCAG
TGTCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACTCACCATGGTCTGCCCTCACC
CCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAAATGCACTTTCTTCCTCCCCT
CTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTATGTATCGTATGTGCATCTTTGCT
ATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCTGCTTAGGGAAGAGGGGTTTCACTTGTATCTCCT
TAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTCCTGTCCCTGTGAGTGGGAAGGTCTTCTGGCTCCCCATCCCACC
TGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGGATCATGGGGGTTTCTTACCC
CACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGGAGGTGGGGACAGGGGTCTGA
ATGCCGAGTCCCTGAATTCACCCAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACTCTCCCTGATGAATAGAATAT
ACACACTGTGCTAGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGACTGTTCTGCTGTTAAGATAA
TGTATACTCTTTTATTTTCTTCCTTTCATGGTTAAGATTTTTTTTTTAAGAAAAGTTAAATATCCTTCA
  • refseq_ARHGEF11.F2 (forward primer)
  • refseq_ARHGEF11.R2 (reverse primer)
  • Single exon skipping

Frame 0

SEISVSWRLRQEKISEPGCGGAQQQN*LRKLSF
RKRPNVGWV*ESGWGRWRNLQV*RKKKRREYFQR
LSLVCYHYYHLKGKKHCISGVL*FLFYFFFWCN
WLI*EFQNI*CKSFFFFKEVHKFWFPGLHWTWK
ECCCVHTIVWFYLLFYCTNQPKEFFQVPFRIY*S
FFFSFPQRYLLLSY*ALETRKLLSPFELEGLLP
TEGQLRKLDLKDGFICTLQLTVIF*RHIFL*FI
FFWP*C*P*RDSWLGFWFLRRS*FFLFSFFFLFS
FLFFFFKAGEGKRG*ERKSCSLVEVEWSISYQG
PESWRRKDSIFKLGGPPLTLLKNCKRFNPDQDT
KATGFWNRGDTEKP*V*GYPRV*TG*VACLLWEI
LHQSASPLPTIASLRMPLRQQVSFNAVSLSKRT
SMASASQSVGIALFWCSLCGLEVQP*RPV*KRA
TGSSKSTAPW*PIAHTWKW*S*SNLAPMSHSPSW
ALHLHPWASLGSSRTHPQQELPESRQ*SPHHHL
LHLYHLHNASQDPNLCRIPKFKNMPPRSSGIC*
GRKKKNYRTYFHYMVTPARDHQKAGSLWIPRRGT
VAWTLGQNAFLPSVSH**IGTRYCQTLG*TVLE
PPL*SWPGWPSTTGGRARMQQSPQPVTRV*IKA
QSL*LLAQRKTMTRVISTTRATSYSRIWRN*SLG
QLTWGFFYVTSSLRRTPVHCFFTCVQKFISRQA
PRIPEAWGKTSGIFSWRKMRL*E*RSLRCYRLK
LTRACGTAKMPVVFSVKLKRQPCLRSKSRSTTTE
RSAHWGWAACMVKMTCWTWMGTLSESAKWLRSS
WLPLEIFCPSMRKTGAPPWTSPSIPT*AMLGSV
FERHDLPTQLKRPSLLLTRTSGYRSSLRPRRAAI
PRKKRMPWRTRSETLSSNTLGSPKALLKAHFIF
PCPLWKSNQAM*GTSFSTLRTTSSMMPQNLGHN
DSRPEAFLRTCWRVTVHAQRFAWAALKASRAGKR
*NGLERQRTCPALAVMLTWMLLRRLLACTSQPR
PLPPASPPGLLRTQPLHSLPKWAAGALSPPVWG
SAQIPSFPTS*RMIWASCLTWSQSQMPKIGSIQW
ARMWWLG*PSGRLTGKRSSMSCL*LKLPTCAHS
GSWT*SSTSE*RRRT*CPGRSWPGSSRTCLNS*
RFTIPGVKP*RSSGRKAPSSKRSVTSCWPGLMAL
PERNSSKWLHSSVPISQ*P*S*SRPSNARRVDS
SSSCRRLRATLSVGGCS*ETSSSLRCSGSPSTR
CCWRASSSTQRVAPLSMRSCAGPGTSAGRFSSM*
MKR*NKQRTATV*RATRNAWMPPPWRGPATPWQ
QSSRAWILQPEK*SMRDP*PGGSARIRPWTSTC
CCWRTS*CCYRNRMRSYC*SATARLLWAPQTASR
PSAPCSSSMLCSSALWPQINGPSSSSAPPSWAH
PRSMSWLH*RHQTRTHGWSS*KRPCGMPPGTPE
LPQCPSILHPQVPGSQPSRAPHPAG*NWMTQTCS
MVNLNLRSCLEALGPSRGSKGSTRSC*RTLSRR
AVQRKRNWVSCLALPHPWMERTGASGQGTPSTW
PSQALCSWKGSLTPLWKMWRTCDI*SCGACCQVT
PWKLRLPRSPRTT*HPHLLSSASPLTPGTQAPQ
GKHPLGVKGTTPSLQGWRGNGQSRKTWVSVLWN
TYPQGPEILGYGSLQNWTGIWLKMLQAQRQQEVT
KL*EKLRWQAARLSLHYQRVASQSLGHLKWKAE
QRLRGTAFMSACHQDPRTQAPTTQRHP*APLSL
TASLQGRQSLSLSCREATMIQDAPAALLQAWPSG
TWA*SSIPLSSSLSSSTGSRIWSWPTESCSSPL
GESHLVAPRLWAVSTQKQLDGQMAPSHLPLRSP
*LLTPGTAMNWGPALRMALTPPWKTAQQTQPRHQ
DHNRTNHQILCVPTPPSGTGLRPGHRVGGIPTL
LPVEEAVRETRIQPRPGGRPACCLVCSSRSQVS
VSFPSLSPTLQGLMSPKHADCIRKAPTHHGLPSP
HICVYTRTPVCALPSDMQVKGGGFCVNALSSSP
LSP*DPRQRWVPPLPSLSLWFPINMYVSYVHLC
YCK*L*PFLFLFLKCWRQLWKELLREEGFHLYLL
S*QPSSRIEPKAGARPECSCPCEWEGLLAPHPT
WLQSLPSTACCQATPSLPGLLIFTRWGSWGFLT
PPMSPSSPPCPCRKPVKQVRS*GLGPRRWGQGSE
CRVPEFTQDHPRGHRSIGPITTSSPNSP**IEY
THCARCIYTYIYI*IYI*YIKYRYGNDCSAVKI
MYTLLFSSFHG*DFFFKKS*ISF

Frame 1

AKSPFHGG*GKRKFRSLDVEEPNSRTNSGNCLS
EKGRT*AGSENQAGVGGGTCKFKGKRKGENIFR
DYLWFVIITTILKVKSIAFQVFFDFYFIFFFGAI
GSFKNFKTFNVKAFFFLRKSINFGSQGCTGLGR
SAVVYILLYGFIYYFTVQISRKNFSKCHFGFIN
PFFFPFLKDICCCHIKHWRLENYFPPLS*RVSCQ
QKDS*ESWI*RMVLSVLCS*Q*YFEGTFFCDSF
FFGHSANLEEIRGWVFGF*EGRSFSSFPFFFFF
LFFSFFLKRGRGRGAEKGNHVHW*K*SGASVTRV
LRAGGERILSSSWEALLSPCSKIASDSILIKTP
KLQDSGTVETPRNHECKVTPEYRQVK*PVFSGR
FCTRAQVPFPPSPAFGCL*DNRSRSTLCHYPKGP
AWLRLHSQWGSHCSGAVCAAWRCSHEGRCERGR
PDHQSQRHHGDQ*LTPGSGKADQIWRLCRTHPP
GLFTFIHGHLWAPAGPIPSRSSPNHVSDPLTTTS
STSTTSTTHHRTQTSAGSRSSKTCHPDPQEYAE
AGRKRITGHTSTIW*HQPETIRRPALSGFPGGG
QWLGLWDRTLSFPQ*VIDESELGTVRPWARQSSN
LPCDHGQGGPAPQAAGLGCSSPLNR*PGCRSKP
KAFNYWPRGRL*PGLFQQRERHHIPGSGETEVS
ASSPGGFSTLHLLSGGPQSTAFLPVCRSLSAGKP
QGFPKLGERHLEYFPGEKCASESEDP*DATG*N
*LAPAEQRRCPWCSL*SSRGSHA*DPRADPRLQ
NEAHTGAGQPVW*K*PAGPGWGPSPRAPSG*EAA
GCPWRYFVQV*GRQERPHGLRPQYLHEPCWDPS
SRGTTFQHS*KGPVCS*QGQVATVLP*DQEEQQ
FQERKGCLGGQEAKPYPQIHWEAQKLFSKHISYS
LVPCGSQTRQCEEHHSAL*EQPAV*CPRTWDTT
TLDRKLS*GPAGE*QFTLRDSPGPL*KPQGPGR
DETVSKGRERAPLSQ*C*HGCCCGGYSPAPVSLV
LYLQPLHQVS*EPNPSIHSQNGPQEH*VPQFGV
LHRYPPSPPPRG*SGPAV*PGARARCPKLAAYS
GQGCGGWANPAGD*PARGHQ*AVCD*SFPPAHTP
GPGPDLLPANEEGEPDAPGGAGPALPEPA*THR
DSQFLV*SHEEAPGGRPHHQRDQ*PHAGPV*WP
CPRGTPASGCTVLFLSVNSPRANQDQATQGESIP
ALHAGG*EPPSVSAAAAERPHHL*DAAAHQVPA
AAGEHHQAHRGWHL*A*EAVPGPGPVPGDSQVC
E*SGKTNREPPPFRGLPETPGCHRPGEGQQPPGS
RVQEPGSYNQKNDP*GTPDLEDQQG*DLGPPRA
AAGGPPSAATETG*EAIAEVPQQDCCGLLRQQA
DLQPRAQAQCCAHPLCGHR*TGLLHHLHLQAGPT
PDL*AGCIDVIRQEHMDGALRRGRAECHQAPRS
CPNARPSSTPRSPGASPAGPHTQQGRTG*LRRV
PW*T*T*GAAWRHWVPAEGPREAPGPARGP*AGG
QCRGRGTGCPALPFHIPGWREQGHQDKEPHPLG
LPRPSVHGRAR*LRSGRCGEPATSDPVEPAARS
HHGNSGCPGARGRPDTHTFCHQRHLSPLGPRLPR
ASTPWG*RGQHPACRAGGGTARAGRHGSLFSGT
PTPKDQKFWDMGVSRTGQESG*RCFKHRGSRRL
QSCEKS*GGRQQGCPCTTREWPVRAWAT*SGRRN
KGYGELLLCQHAIRTPGLKHRPLRGTHEPPSA*
QPPCRADRASASAAGRQR*SKTPQPLSSKPGPQ
GRGHDLPYH*AAHSQAQQAQGYGAGPQRAAQVPW
GRVIWWHHACGQFPHRSS*MDRWLPLTSR*GAP
SF*LQEQP*TGALP*GWL*RPPGRQHSRRSRVT
RTITVQTTKSSASPLLLQGLA*DRGTG*GGSQHS
SLWRRQLGKLGSSQGPGGDPHVAWSAQVGVRFQ
CLFPPLAQPSKASCLLSMLTASERPPLTMVCPH
PTYVCTRARLYVRCPQTCK*KEEASV*MHFLPPL
FLHKTPGRGGCLPSPLCHFGFL*ICMYRMCIFA
IVNNFDLFCSCS*SAGGSYGRSCLGKRGFTCIS
LVNNPVPGSSLKREPGLSVPVPVSGKVFWLPIPP
GSRACPPQLAAKLLPPSLDFSSSQDGDHGGFLP
HLCPPLPHPVPVENQ*SRYGAEDWAPGGGDRGL
NAESLNSPRTIQGATAALAPSPRPHPTLPDE*NI
HTVLGVYIHIYIYKYIYNI*NIDMEMTVLLLR*
CILFYFLPFMVKIFFLRKVKYPS

Frame 2

RNLRFMEAEARENFGAWMWRSPTAELTQEIVFQ
KKAERRLGLRIRLG*VEEPASLKEKEKERIFSE
IISGLLSLLPS*R*KALHFRCSLIFILFFFLVQ
LAHLRISKHLM*KLFFF*GSP*ILVPRVALDLEG
VLLCTYYCMVLFIILLYKSAERIFPSAISDLLI
LFFFLSSKIFAVVILSIGD*KITFPL*ARGSLA
NRRTAEKAGFKGWFYLYFAVNSDILKAHFSVIHF
FLAIVLTLKRFVAGFLVSEKVVVFPLFLFFSFF
FSFLFF*SGGGEEGLRKEIMFTGRSRVEHQLPG
S*ELEEKGFYLQVGRPSSHLAQKLQAIQS*SRHQ
SYRILEPWRHRETMSVRLPQSIDRLSSLSSLGD
SAPERKSPSHHRQPSDASETTGLVQRCVIIQKD
QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGD
RIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPP
PPPLPPPQRITGPKPLQDPEVQKHATQILRNMLR
QEEKELQDILPLYGDTSQRPSEGRLSLDSQEGD
SGLDSGTERFPSLSESLMNRNSVLSDPGLDSPR
TSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSP
KPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR
PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQAS
PKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEI
DSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR
TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQ
LAALGDILSKYEEDRSAPMDFALNTYMSHAGIRL
REARPSNTAEKAQSAPDKDKWLPFFPKTKKSSN
SKKEKDALEDKKRNPILKYIGKPKSSSQSTFHI
PLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQR
LSTGSFPEDLLESDSSRSEIRLGRSESLKGREE
MKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS
SSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGF
CTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV
GKDVVAGLTQREIDRQEVINELFVTEASHLRTL
RVLDLIFYQRMKKENLMPREELARLFPNLPELIE
IHNSWCEAMKKLREEGPIIKEISDLMLARFDGP
AREELQQVAAQFCSYQSIALELIKTKQRKESRF
QLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPL
LLESIIKHTEGGTSEHEKLCRARDQCREILKYV
NEAVKQTENRHRLEGYQKRLDATALERASNPLA
AEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVL
LLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ
TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGP
PQIYELVALTSSDKNTWMELLEEAVRNATRHPGA
APMPVHPPPPGPREPAQQGPTPSRVELDDSDVF
HGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQE
GSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLA
FPGPLFMEGLADSALEDVENLRHLILWSLLPGH
TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSP
GQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEH
LPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGG
TKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPD
SLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALR
DVGMIFHTIEQLTLKLNRLKDMELAHRELLKSL
GGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPL
ASDSRNSHELGPCPEDGSDAPLEDSTADAAASP
GP*PYKPPNPLRPHSSFRDWPETGAQGRGDPNT
PPCGGGS*GN*DPAKARGETRMLLGLLKSESGFS
VFSLP*PNPPRPHVS*AC*LHPKGPHSPWSALT
PHMCVHAHACMCAALRHASERRRLLCKCTFFLP
SFSIRPQAEVGASPPLFVTLVSYKYVCIVCASLL
L*ITLTFFVPVPEVLEAVMEGAA*GRGVSLVSP
*LTTQFQDRA*SGSQA*VFLSL*VGRSSGSPSH
LAPEPALHSLLPSYSLPPWTSHLHKMGIMGVSYP
TYVPLFPTLSL*KTSEAGTELRTGPQEVGTGV*
MPSP*IHPGPSKGPPQHWPHHHVLTQLSLMNRI
YTLC*VYIYIYIYINIYIIYKI*IWK*LFCC*DN
VYSFIFFLSWLRFFF*EKLNIL

Sequence NM_198236

AGCGAAATCTCCGTTTCATGGAGGCTGAGGCAAGAGAAAATTTCGGAGCCTGGATGTGGAGGAGCCCAACAGCAGAACTAACTCAGGAAATTGTCTTTCA
GAAAAAGGCCGAACGTAGGCTGGGTCTGAGAATCAGGCTGGGGTAGGTGGAGGAACCTGCAAGTTTAAAGGAAAAAGAAAAGGAGAGAATATTTTCAGAG
ATTATCTCTGGTTTGTTATCATTACTACCATCTTAAAGGTAAAAAGCATTGCATTTCAGGTGTTCTTTGATTTTTATTTTATTTTTTTTTTTGGTGCAAT
TGGCTCATTTAAGAATTTCAAAACATTTAATGTAAAAGCTTTTTTTTTTTTAAGGAAGTCCATAAATTTTGGTTCCCAGGGTTGCACTGGACTTGGAAGG
AGTGCTGTTGTGTACATACTATTGTATGGTTTTATTTATTATTTTACTGTACAAATCAGCCGAAAGAATTTTTCCAAGTGCCATTTCGGATTTATTAATC
CTTTTTTTTTTCCTTTCCTCAAAGATATTTGCTGTTGTCATATTAAGCATTGGAGACTAGAAAATTACTTTCCCCCTTTGAGCTAGAGGGTCTCTTGCCA
ACAGAAGGACAGCTGAGAAAGCTGGATTTAAAGGATGGTTTTATCTGTACTTTGCAGTTAACAGTGATATTTTGAAGGCACATTTTTCTGTGATTCATTT
TTTTTTGGCCATAGTGCTAACCTTGAAGAGATTCGTGGCTGGGTTTTTGGTTTCTGAGAAGGTCGTAGTTTTTCCTCTTTTCCTTTTTTTTTCTTTTTTC
TTTTCTTTTCTTTTTTTTTAAAGCGGGGGAGGGGAAGAGGGGCTGAGAAAGGAAATCATGTTCACTGGTAGAAGTAGAGTGGAGCATCAGTTACCAGGGT
CCTGAGAGCTGGAGGAGAAAGGATTCTATCTTCAAGTTGGGAGGCCCTCCTCTCACCTTGCTCAAAAATTGCAAGCGATTCAATCCTGATCAAGACACCA
AAGCTACAGGATTCTGGAACCGTGGAGACACCGAGAAACCATGAGTGTAAGGTTACCCCAGAGTATAGACAGGTTAAGTAGCCTGTCTTCTCTGGGAGAT
TCTGCACCAGAGCGCAAGTCCCCTTCCCACCATCGCCAGCCTTCGGATGCCTCTGAGACAACAGGTCTCGTTCAACGCTGTGTCATTATCCAAAAGGACC
AGCATGGCTTCGGCTTCACAGTCAGTGGGGATCGCATTGTTCTGGTGCAGTCTGTGCGGCCTGGAGGTGCAGCCATGAAGGCCGGTGTGAAAGAGGGCGA
CCGGATCATCAAAGTCAACGGCACCATGGTGACCAATAGCTCACACCTGGAAGTGGTAAAGCTGATCAAATCTGGCGCCTATGTCGCACTCACCCTCCTG
GGCTCTTCACCTTCATCCATGGGCATCTCTGGGCTCCAGCAGGACCCATCCCCAGCAGGAGCTCCCCGAATCACGTCAGTGATCCCCTCACCACCACCTC
CTCCACCTCTACCACCTCCACAACGCATCACAGGACCCAAACCTCTGCAGGATCCCGAAGTTCAAAAACATGCCACCCAGATCCTCAGGAATATGCTGAG
GCAGGAAGAAAAAGAATTACAGCGTATCTGTGAGGTCTATAGCCGGAACCCCGCCAGCCTACTGGAAGAGCAGATCGAAGGTGCCCGGCGGCGAGTCACT
CAGTTACAGCTGAAGATCCAGCAGGAGACTGGTGGCTCAGTG
GACATACTTCCACTATATGGTGACACCAGCCAGAGACCATCAGAAGGCCGGCTCTCTC
TGGATTCCCAGGAGGGGGACAGTGGCTTGGACTCTGGGACAGAACGCTTTCCTTCCCTCAGTGAGTCATTGATGAATCGGAACTCGGTACTGTCAGACCC
T
GGGCTAGACAGTCCTCGAACCTCCCCTGTGATCATGGCCAGGGTGGCCCAGCACCACAGGCGGCAGGGCTCGGATGCAGCAGTCCCCTCAACCGGTGAC
CAGGGTGTAGATCAAAGCCCAAAGCCTTTAATTATTGGCCCAGAGGAAGACTATGACCCGGGTTATTTCAACAACGAGAGCGACATCATATTCCAGGATC
TGGAGAAACTGAAGTCTCGGCCAGCTCACCTGGGGGTTTTTCTACGTTACATCTTCTCTCAGGCGGACCCCAGTCCACTGCTTTTTTACCTGTGTGCAGA
AGTTTATCAGCAGGCAAGCCCCAAGGATTCCCGAAGCTTGGGGAAAGACATCTGGAATATTTTCCTGGAGAAAAATGCGCCTCTGAGAGTGAAGATCCCT
GAGATGCTACAGGCTGAAATTGACTCGCGCCTGCGGAACAGCGAAGATGCCCGTGGTGTTCTCTGTGAAGCTCAAGAGGCAGCCATGCCTGAGATCCAAG
AGCAGATCCACGACTACAGAACGAAGCGCACACTGGGGCTGGGCAGCCTGTATGGTGAAAATGACCTGCTGGACCTGGATGGGGACCCTCTCCGAGAGCG
CCAAGTGGCTGAGAAGCAGCTGGCTGCCCTTGGAGATATTTTGTCCAAGTATGAGGAAGACAGGAGCGCCCCCATGGACTTCGCCCTCAATACCTACATG
AGCCATGCTGGGATCCGTCTTCGAGAGGCACGACCTTCCAACACAGCTGAAAAGGCCCAGTCTGCTCCTGACAAGGACAAGTGGCTACCGTTCTTCCCTA
AGACCAAGAAGAGCAGCAATTCCAAGAAAGAAAAGGATGCCTTGGAGGACAAGAAGCGAAACCCTATCCTCAAATACATTGGGAAGCCCAAAAGCTCTTC
TCAAAGCACATTTCATATTCCCTTGTCCCCTGTGGAAGTCAAACCAGGCAATGTGAGGAACATCATTCAGCACTTTGAGAACAACCAGCAGTATGATGCC
CCAGAACCTGGGACACAACGACTCTCGACCGGAAGCTTTCCTGAGGACCTGCTGGAGAGTGACAGTTCACGCTCAGAGATTCGCCTGGGCCGCTCTGAAA
GCCTCAAGGGCCGGGAAGAGATGAAACGGTCTCGAAAGGCAGAGAACGTGCCCCGCTCTCGCAGTGATGTTGACATGGATGCTGCTGCGGAGGCTACTCG
CCTGCACCAGTCAGCCTCGTCCTCTACCTCCAGCCTCTCCACCAGGTCTCTTGAGAACCCAACCCCTCCATTCACTCCCAAAATGGGCCGCAGGAGCATT
GAGTCCCCCAGTTTGGGGTTCTGCACAGATACCCTCCTTCCCCACCTCCTAGAGGATGATCTGGGCCAGCTGTCTGACCTGGAGCCAGAGCCAGATGCCC
AAAATTGGCAGCATACAGTGGGCAAGGATGTGGTGGCTGGGCTAACCCAGCGGGAGATTGACCGGCAAGAGGTCATCAATGAGCTGTTTGTGACTGAAGC
TTCCCACCTGCGCACACTCCGGGTCCTGGACCTGATCTTCTACCAGCGAATGAAGAAGGAGAACCTGATGCCCCGGGAGGAGCTGGCCCGGCTCTTCCCG
AACCTGCCTGAACTCATAGAGATTCACAATTCCTGGTGTGAAGCCATGAAGAAGCTCCGGGAGGAAGGCCCCATCATCAAAGAGATCAGTGACCTCATGC
TGGCCCGGTTTGATGGCCCTGCCCGAGAGGAACTCCAGCAAGTGGCTGCACAGTTCTGTTCCTATCAGTCAATAGCCCTAGAGCTAATCAAGACCAAGCA
ACGCAAGGAGAGTCGATTCCAGCTCTTCATGCAGGAGGCTGAGAGCCACCCTCAGTGTCGGCGGCTGCAGCTGAGAGACCTCATCATCTCTGAGATGCAG
CGGCTCACCAAGTACCCGCTGCTGCTGGAGAGCATCATCAAGCACACAGAGGGTGGCACCTCTGAGCATGAGAAGCTGTGCCGGGCCCGGGACCAGTGCC
GGGAGATTCTCAAGTATGTGAATGAAGCGGTAAAACAAACAGAGAACCGCCACCGTTTAGAGGGCTACCAGAAACGCCTGGATGCCACCGCCCTGGAGAG
GGCCAGCAACCCCCTGGCAGCAGAGTTCAAGAGCCTGGATCTTACAACCAGAAAAATGATCCATGAGGGACCCCTGACCTGGAGGATCAGCAAGGATAAG
ACCTTGGACCTCCACGTGCTGCTGCTGGAGGACCTCCTAGTGCTGCTACAGAAACAGGATGAGAAGCTATTGCTGAAGTGCCACAGCAAGACTGCTGTGG
GCTCCTCAGACAGCAAGCAGACCTTCAGCCCCGTGCTCAAGCTCAATGCTGTGCTCATCCGCTCTGTGGCCACAGATAAACGGGCCTTCTTCATCATCTG
CACCTCCAAGCTGGGCCCACCCCAGATCTATGAGCTGGTTGCATTGACGTCATCAGACAAGAACACATGGATGGAGCTCTTAGAAGAGGCCGTGCGGAAT
GCCACCAGGCACCCCGGAGCTGCCCCAATGCCCGTCCATCCTCCACCCCCAGGTCCCCGGGAGCCAGCCCAGCAGGGCCCCACACCCAGCAGGGTAGAAC
TGGATGACTCAGACGTGTTCCATGGTGAACCTGAACCTGAGGAGCTGCCTGGAGGCACTGGGTCCCAGCAGAGGGTCCAAGGGAAGCACCAGGTCCTGCT
AGAGGACCCTGAGCAGGAGGGCAGTGCAGAGGAAGAGGAACTGGGTGTCCTGCCTTGCCCTTCCACATCCCTGGATGGAGAGAACAGGGGCATCAGGACA
AGGAACCCCATCCACTTGGCCTTCCCAGGCCCTCTGTTCATGGAAGGGCTCGCTGACTCCGCTCTGGAAGATGTGGAGAACCTGCGACATCTGATCCTGT
GGAGCCTGCTGCCAGGTCACACCATGGAAACTCAGGCTGCCCAGGAGCCCGAGGACGACCTGACACCCACACCTTCTGTCATCAGCGTCACCTCTCACCC
CTGGGACCCAGGCTCCCCAGGGCAAGCACCCCCTGGGGGTGAAGGGGACAACACCCAGCTTGCAGGGCTGGAGGGGGAACGGCCAGAGCAGGAAGACATG
GGTCTCTGTTCTCTGGAACACCTACCCCCAAGGACCAGAAATTCTGGGATATGGGAGTCTCCAGAACTGGACAGGAATCTGGCTGAAGATGCTTCAAGCA
CAGAGGCAGCAGGAGGTTACAAAGTTGTGAGAAAAGCTGAGGTGGCAGGCAGCAAGGTTGTCCCTGCACTACCAGAGAGTGGCCAGTCAGAGCCTGGGCC
ACCTGAAGTGGAAGGCGGAACAAAGGCTACGGGGAACTGCTTTTATGTCAGCATGCCATCAGGACCCCCGGACTCAAGCACCGACCACTCAGAGGCACCC
ATGAGCCCCCCTCAGCCTGACAGCCTCCCTGCAGGGCAGACAGAGCCTCAGCCTCAGCTGCAGGGAGGCAACGATGATCCAAGACGCCCCAGCCGCTCTC
CTCCAAGCCTGGCCCTCAGGGACGTGGGCATGATCTTCCATACCATTGAGCAGCTCACTCTCAAGCTCAACAGGCTCAAGGATATGGAGCTGGCCCACAG
AGAGCTGCTCAAGTCCCTTGGGGGAGAGTCATCTGGTGGCACCACGCCTGTGGGCAGTTTCCACACAGAAGCAGCTAGATGGACAGATGGCTCCCTCTCA
CCTCCCGCTAAGGAGCCCCTAGCTTCTGACTCCAGGAACAGCCATGAACTGGGGCCCTGCCCTGAGGATGGCTCTGACGCCCCCCTGGAAGACAGCACAG
CAGACGCAGCCGCGTCACCAGGACCATAACCGTACAAACCACCAAATCCTCTGCGTCCCCACTCCTCCTTCAGGGACTGGCCTGAGACCGGGGCACAGGG
TAGGGGGGATCCCAACACTCCTCCCTGTGGAGGAGGCAGTTAGGGAAACTAGGATCCAGCCAAGGCCCGGGGGGAGACCCGCATGTTGCTTGGTCTGCTC
AAGTCGGAGTCAGGTTTCAGTGTCTTTTCCCTCCCTTAGCCCAACCCTCCAAGGCCTCATGTCTCCTAAGCATGCTGACTGCATCCGAAAGGCCCCCACT
CACCATGGTCTGCCCTCACCCCACATATGTGTGTACACGCGCACGCCTGTATGTGCGCTGCCCTCAGACATGCAAGTGAAAGGAGGAGGCTTCTGTGTAA
ATGCACTTTCTTCCTCCCCTCTTTCTCCATAAGACCCCAGGCAGAGGTGGGTGCCTCCCCTCCCCTCTTTGTCACTTTGGTTTCCTATAAATATGTATGT
ATCGTATGTGCATCTTTGCTATTGTAAATAACTTTGACCTTTTTTGTTCCTGTTCCTGAAGTGCTGGAGGCAGTTATGGAAGGAGCTGCTTAGGGAAGAG
GGGTTTCACTTGTATCTCCTTAGTTAACAACCCAGTTCCAGGATCGAGCCTAAAGCGGGAGCCAGGCCTGAGTGTTCCTGTCCCTGTGAGTGGGAAGGTC
TTCTGGCTCCCCATCCCACCTGGCTCCAGAGCCTGCCCTCCACAGCTTGCTGCCAAGCTACTCCCTCCCTCCCTGGACTTCTCATCTTCACAAGATGGGG
ATCATGGGGGTTTCTTACCCCACCTATGTCCCCCTCTTCCCCACCCTGTCCCTGTAGAAAACCAGTGAAGCAGGTACGGAGCTGAGGACTGGGCCCCAGG
AGGTGGGGACAGGGGTCTGAATGCCGAGTCCCTGAATTCACCCAGGACCATCCAAGGGGCCACCGCAGCATTGGCCCCATCACCACGTCCTCACCCAACT
CTCCCTGATGAATAGAATATACACACTGTGCTAGGTGTATATATACATATATATATATATAAATATATATATAATATATAAAATATAGATATGGAAATGA
CTGTTCTGCTGTTAAGATAATGTATACTCTTTTATTTTCTTCCTTTCATGGTTAAGATTTTTTTTTTAAGAAAAGTTAAATATCCTTCA
  • refseq_ARHGEF11.F2 (forward primer)
  • refseq_ARHGEF11.R2 (reverse primer)
  • Single exon skipping

Frame 0

SEISVSWRLRQEKISEPGCGGAQQQN*LRKLSF
RKRPNVGWV*ESGWGRWRNLQV*RKKKRREYFQR
LSLVCYHYYHLKGKKHCISGVL*FLFYFFFWCN
WLI*EFQNI*CKSFFFFKEVHKFWFPGLHWTWK
ECCCVHTIVWFYLLFYCTNQPKEFFQVPFRIY*S
FFFSFPQRYLLLSY*ALETRKLLSPFELEGLLP
TEGQLRKLDLKDGFICTLQLTVIF*RHIFL*FI
FFWP*C*P*RDSWLGFWFLRRS*FFLFSFFFLFS
FLFFFFKAGEGKRG*ERKSCSLVEVEWSISYQG
PESWRRKDSIFKLGGPPLTLLKNCKRFNPDQDT
KATGFWNRGDTEKP*V*GYPRV*TG*VACLLWEI
LHQSASPLPTIASLRMPLRQQVSFNAVSLSKRT
SMASASQSVGIALFWCSLCGLEVQP*RPV*KRA
TGSSKSTAPW*PIAHTWKW*S*SNLAPMSHSPSW
ALHLHPWASLGSSRTHPQQELPESRQ*SPHHHL
LHLYHLHNASQDPNLCRIPKFKNMPPRSSGIC*
GRKKKNYSVSVRSIAGTPPAYWKSRSKVPGGESL
SYS*RSSRRLVAQW
TYFHYMVTPARDHQKAGSL
WIPRRGTVAWTLGQNAFLPSVSH**IGTRYCQT
L
G*TVLEPPL*SWPGWPSTTGGRARMQQSPQPVT
RV*IKAQSL*LLAQRKTMTRVISTTRATSYSRI
WRN*SLGQLTWGFFYVTSSLRRTPVHCFFTCVQ
KFISRQAPRIPEAWGKTSGIFSWRKMRL*E*RSL
RCYRLKLTRACGTAKMPVVFSVKLKRQPCLRSK
SRSTTTERSAHWGWAACMVKMTCWTWMGTLSES
AKWLRSSWLPLEIFCPSMRKTGAPPWTSPSIPT*
AMLGSVFERHDLPTQLKRPSLLLTRTSGYRSSL
RPRRAAIPRKKRMPWRTRSETLSSNTLGSPKAL
LKAHFIFPCPLWKSNQAM*GTSFSTLRTTSSMMP
QNLGHNDSRPEAFLRTCWRVTVHAQRFAWAALK
ASRAGKR*NGLERQRTCPALAVMLTWMLLRRLL
ACTSQPRPLPPASPPGLLRTQPLHSLPKWAAGAL
SPPVWGSAQIPSFPTS*RMIWASCLTWSQSQMP
KIGSIQWARMWWLG*PSGRLTGKRSSMSCL*LK
LPTCAHSGSWT*SSTSE*RRRT*CPGRSWPGSSR
TCLNS*RFTIPGVKP*RSSGRKAPSSKRSVTSC
WPGLMALPERNSSKWLHSSVPISQ*P*S*SRPS
NARRVDSSSSCRRLRATLSVGGCS*ETSSSLRCS
GSPSTRCCWRASSSTQRVAPLSMRSCAGPGTSA
GRFSSM*MKR*NKQRTATV*RATRNAWMPPPWR
GPATPWQQSSRAWILQPEK*SMRDP*PGGSARIR
PWTSTCCCWRTS*CCYRNRMRSYC*SATARLLW
APQTASRPSAPCSSSMLCSSALWPQINGPSSSS
APPSWAHPRSMSWLH*RHQTRTHGWSS*KRPCGM
PPGTPELPQCPSILHPQVPGSQPSRAPHPAG*N
WMTQTCSMVNLNLRSCLEALGPSRGSKGSTRSC
*RTLSRRAVQRKRNWVSCLALPHPWMERTGASGQ
GTPSTWPSQALCSWKGSLTPLWKMWRTCDI*SC
GACCQVTPWKLRLPRSPRTT*HPHLLSSASPLT
PGTQAPQGKHPLGVKGTTPSLQGWRGNGQSRKTW
VSVLWNTYPQGPEILGYGSLQNWTGIWLKMLQA
QRQQEVTKL*EKLRWQAARLSLHYQRVASQSLG
HLKWKAEQRLRGTAFMSACHQDPRTQAPTTQRHP
*APLSLTASLQGRQSLSLSCREATMIQDAPAAL
LQAWPSGTWA*SSIPLSSSLSSSTGSRIWSWPT
ESCSSPLGESHLVAPRLWAVSTQKQLDGQMAPSH
LPLRSP*LLTPGTAMNWGPALRMALTPPWKTAQ
QTQPRHQDHNRTNHQILCVPTPPSGTGLRPGHR
VGGIPTLLPVEEAVRETRIQPRPGGRPACCLVCS
SRSQVSVSFPSLSPTLQGLMSPKHADCIRKAPT
HHGLPSPHICVYTRTPVCALPSDMQVKGGGFCV
NALSSSPLSP*DPRQRWVPPLPSLSLWFPINMYV
SYVHLCYCK*L*PFLFLFLKCWRQLWKELLREE
GFHLYLLS*QPSSRIEPKAGARPECSCPCEWEG
LLAPHPTWLQSLPSTACCQATPSLPGLLIFTRWG
SWGFLTPPMSPSSPPCPCRKPVKQVRS*GLGPR
RWGQGSECRVPEFTQDHPRGHRSIGPITTSSPN
SP**IEYTHCARCIYTYIYI*IYI*YIKYRYGND
CSAVKIMYTLLFSSFHG*DFFFKKS*ISF

Frame 1

AKSPFHGG*GKRKFRSLDVEEPNSRTNSGNCLS
EKGRT*AGSENQAGVGGGTCKFKGKRKGENIFR
DYLWFVIITTILKVKSIAFQVFFDFYFIFFFGAI
GSFKNFKTFNVKAFFFLRKSINFGSQGCTGLGR
SAVVYILLYGFIYYFTVQISRKNFSKCHFGFIN
PFFFPFLKDICCCHIKHWRLENYFPPLS*RVSCQ
QKDS*ESWI*RMVLSVLCS*Q*YFEGTFFCDSF
FFGHSANLEEIRGWVFGF*EGRSFSSFPFFFFF
LFFSFFLKRGRGRGAEKGNHVHW*K*SGASVTRV
LRAGGERILSSSWEALLSPCSKIASDSILIKTP
KLQDSGTVETPRNHECKVTPEYRQVK*PVFSGR
FCTRAQVPFPPSPAFGCL*DNRSRSTLCHYPKGP
AWLRLHSQWGSHCSGAVCAAWRCSHEGRCERGR
PDHQSQRHHGDQ*LTPGSGKADQIWRLCRTHPP
GLFTFIHGHLWAPAGPIPSRSSPNHVSDPLTTTS
STSTTSTTHHRTQTSAGSRSSKTCHPDPQEYAE
AGRKRITAYL*GL*PEPRQPTGRADRRCPAASH
SVTAEDPAGDWWLS
GHTSTIW*HQPETIRRPALS
GFPGGGQWLGLWDRTLSFPQ*VIDESELGTVRP
WARQSSNLPCDHGQGGPAPQAAGLGCSSPLNR*
PGCRSKPKAFNYWPRGRL*PGLFQQRERHHIPGS
GETEVSASSPGGFSTLHLLSGGPQSTAFLPVCR
SLSAGKPQGFPKLGERHLEYFPGEKCASESEDP
*DATG*N*LAPAEQRRCPWCSL*SSRGSHA*DPR
ADPRLQNEAHTGAGQPVW*K*PAGPGWGPSPRA
PSG*EAAGCPWRYFVQV*GRQERPHGLRPQYLH
EPCWDPSSRGTTFQHS*KGPVCS*QGQVATVLP*
DQEEQQFQERKGCLGGQEAKPYPQIHWEAQKLF
SKHISYSLVPCGSQTRQCEEHHSAL*EQPAV*C
PRTWDTTTLDRKLS*GPAGE*QFTLRDSPGPL*K
PQGPGRDETVSKGRERAPLSQ*C*HGCCCGGYS
PAPVSLVLYLQPLHQVS*EPNPSIHSQNGPQEH
*VPQFGVLHRYPPSPPPRG*SGPAV*PGARARCP
KLAAYSGQGCGGWANPAGD*PARGHQ*AVCD*S
FPPAHTPGPGPDLLPANEEGEPDAPGGAGPALP
EPA*THRDSQFLV*SHEEAPGGRPHHQRDQ*PHA
GPV*WPCPRGTPASGCTVLFLSVNSPRANQDQA
TQGESIPALHAGG*EPPSVSAAAAERPHHL*DA
AAHQVPAAAGEHHQAHRGWHL*A*EAVPGPGPVP
GDSQVCE*SGKTNREPPPFRGLPETPGCHRPGE
GQQPPGSRVQEPGSYNQKNDP*GTPDLEDQQG*
DLGPPRAAAGGPPSAATETG*EAIAEVPQQDCCG
LLRQQADLQPRAQAQCCAHPLCGHR*TGLLHHL
HLQAGPTPDL*AGCIDVIRQEHMDGALRRGRAE
CHQAPRSCPNARPSSTPRSPGASPAGPHTQQGRT
G*LRRVPW*T*T*GAAWRHWVPAEGPREAPGPA
RGP*AGGQCRGRGTGCPALPFHIPGWREQGHQD
KEPHPLGLPRPSVHGRAR*LRSGRCGEPATSDPV
EPAARSHHGNSGCPGARGRPDTHTFCHQRHLSP
LGPRLPRASTPWG*RGQHPACRAGGGTARAGRH
GSLFSGTPTPKDQKFWDMGVSRTGQESG*RCFKH
RGSRRLQSCEKS*GGRQQGCPCTTREWPVRAWA
T*SGRRNKGYGELLLCQHAIRTPGLKHRPLRGT
HEPPSA*QPPCRADRASASAAGRQR*SKTPQPLS
SKPGPQGRGHDLPYH*AAHSQAQQAQGYGAGPQ
RAAQVPWGRVIWWHHACGQFPHRSS*MDRWLPL
TSR*GAPSF*LQEQP*TGALP*GWL*RPPGRQHS
RRSRVTRTITVQTTKSSASPLLLQGLA*DRGTG
*GGSQHSSLWRRQLGKLGSSQGPGGDPHVAWSA
QVGVRFQCLFPPLAQPSKASCLLSMLTASERPPL
TMVCPHPTYVCTRARLYVRCPQTCK*KEEASV*
MHFLPPLFLHKTPGRGGCLPSPLCHFGFL*ICM
YRMCIFAIVNNFDLFCSCS*SAGGSYGRSCLGKR
GFTCISLVNNPVPGSSLKREPGLSVPVPVSGKV
FWLPIPPGSRACPPQLAAKLLPPSLDFSSSQDG
DHGGFLPHLCPPLPHPVPVENQ*SRYGAEDWAPG
GGDRGLNAESLNSPRTIQGATAALAPSPRPHPT
LPDE*NIHTVLGVYIHIYIYKYIYNI*NIDMEM
TVLLLR*CILFYFLPFMVKIFFLRKVKYPS

Frame 2

RNLRFMEAEARENFGAWMWRSPTAELTQEIVFQ
KKAERRLGLRIRLG*VEEPASLKEKEKERIFSE
IISGLLSLLPS*R*KALHFRCSLIFILFFFLVQ
LAHLRISKHLM*KLFFF*GSP*ILVPRVALDLEG
VLLCTYYCMVLFIILLYKSAERIFPSAISDLLI
LFFFLSSKIFAVVILSIGD*KITFPL*ARGSLA
NRRTAEKAGFKGWFYLYFAVNSDILKAHFSVIHF
FLAIVLTLKRFVAGFLVSEKVVVFPLFLFFSFF
FSFLFF*SGGGEEGLRKEIMFTGRSRVEHQLPG
S*ELEEKGFYLQVGRPSSHLAQKLQAIQS*SRHQ
SYRILEPWRHRETMSVRLPQSIDRLSSLSSLGD
SAPERKSPSHHRQPSDASETTGLVQRCVIIQKD
QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGD
RIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPP
PPPLPPPQRITGPKPLQDPEVQKHATQILRNMLR
QEEKELQRICEVYSRNPASLLEEQIEGARRRVT
QLQLKIQQETGGSV
DILPLYGDTSQRPSEGRLS
LDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDP
GLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGD
QGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQD
LEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAE
VYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP
EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQ
EQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRER
QVAEKQLAALGDILSKYEEDRSAPMDFALNTYM
SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFP
KTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSS
QSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDA
PEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE
SLKGREEMKRSRKAENVPRSRSDVDMDAAAEATR
LHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI
ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDA
QNWQHTVGKDVVAGLTQREIDRQEVINELFVTEA
SHLRTLRVLDLIFYQRMKKENLMPREELARLFP
NLPELIEIHNSWCEAMKKLREEGPIIKEISDLM
LARFDGPAREELQQVAAQFCSYQSIALELIKTKQ
RKESRFQLFMQEAESHPQCRRLQLRDLIISEMQ
RLTKYPLLLESIIKHTEGGTSEHEKLCRARDQC
REILKYVNEAVKQTENRHRLEGYQKRLDATALER
ASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK
TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAV
GSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIIC
TSKLGPPQIYELVALTSSDKNTWMELLEEAVRN
ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE
LDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLL
EDPEQEGSAEEEELGVLPCPSTSLDGENRGIRT
RNPIHLAFPGPLFMEGLADSALEDVENLRHLIL
WSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHP
WDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM
GLCSLEHLPPRTRNSGIWESPELDRNLAEDASS
TEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGP
PEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP
MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRS
PPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHR
ELLKSLGGESSGGTTPVGSFHTEAARWTDGSLS
PPAKEPLASDSRNSHELGPCPEDGSDAPLEDST
ADAAASPGP*PYKPPNPLRPHSSFRDWPETGAQG
RGDPNTPPCGGGS*GN*DPAKARGETRMLLGLL
KSESGFSVFSLP*PNPPRPHVS*AC*LHPKGPH
SPWSALTPHMCVHAHACMCAALRHASERRRLLCK
CTFFLPSFSIRPQAEVGASPPLFVTLVSYKYVC
IVCASLLL*ITLTFFVPVPEVLEAVMEGAA*GR
GVSLVSP*LTTQFQDRA*SGSQA*VFLSL*VGRS
SGSPSHLAPEPALHSLLPSYSLPPWTSHLHKMG
IMGVSYPTYVPLFPTLSL*KTSEAGTELRTGPQ
EVGTGV*MPSP*IHPGPSKGPPQHWPHHHVLTQL
SLMNRIYTLC*VYIYIYIYINIYIIYKI*IWK*
LFCC*DNVYSFIFFLSWLRFFF*EKLNIL

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