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Sequences

Sequence NM_139026

AACCACGATGTCTTTGGCACAGCCTCTCATCTGTCAGATGGGAGCGGGGACCCCGGAGAGGGAGTCAGCCGAGGTCCTGGCATTCCTTGTGAACCCCCGT
CTGTGGGTTTCTGGTCCAGTGTCCCTTCTCCAGATTAGATGGCTTAGGCCTCCTCTAAGGGGGTGGGCGTGCACATCCGGAGAGCTGTCTGGTGTGCAGG
ACTGGGCTGCAGGTTACCCTGAACTGCAACCATCTTAGAGCAAGGCCCAGCTTGCAGCAGGAGGAGCTGCAGGCCGCCCACCCTAGCCACGGCCCCTGCC
CTGGCAGGAAGCTTCCAAGAGTAAACACTGCCTAATCGTCCCGCCCAGTAGTGAGCAGGCCTGTCCCATTCCATACTGACCAGATTCCCAGTCACCAAGG
CCCCCTCTCACTCCGCTCCACTCCTCGGGCTGGCTCTCCTGAGGATGCACCAGCGTCACCCCCGGGCAAGATGCCCTCCCCTCTGTGTGGCCGGAATCCT
TGCCTGTGGCTTTCTCCTGGGCTGCTGGGGACCCTCCCATTTCCAGCAGAGTTGTCTTCAGGCTTTGGAGCCACAGGCCGTGTCTTCTTACTTGAGCCCT
GGTGCTCCCTTAAAAGGCCGCCCTCCTTCCCCTGGCTTCCAGAGGCAGAGGCAGAGGCAGAGGCGGGCTGCAGGCGGCATCCTACACCTGGAGCTGCTGG
TGGCCGTGGGCCCCGATGTCTTCCAGGCTCACCAGGAGGACACAGAGCGCTATGTGCTCACCAACCTCAACATCGGGGCAGAACTGCTTCGGGACCCGTC
CCTGGGGGCTCAGTTTCGGGTGCACCTGGTGAAGATGGTCATTCTGACAGAGCCTGAGGGTGCCCCAAATATCACAGCCAACCTCACCTCGTCCCTGCTG
AGCGTCTGTGGGTGGAGCCAGACCATCAACCCTGAGGACGACACGGATCCTGGCCATGCTGACCTGGTCCTCTATATCACTAGGTTTGACCTGGAGTTGC
CTGATGGTAACCGGCAGGTGCGGGGCGTCACCCAGCTGGGCGGTGCCTGCTCCCCAACCTGGAGCTGCCTCATTACCGAGGACACTGGCTTCGACCTGGG
AGTCACCATTGCCCATGAGATTGGGCACAGCTTCGGCCTGGAGCACGACGGCGCGCCCGGCAGCGGCTGCGGCCCCAGCGGACACGTGATGGCTTCGGAC
GGCGCCGCGCCCCGCGCCGGCCTCGCCTGGTCCCCCTGCAGCCGCCGGCAGCTGCTGAGCCTGCTCAGCGCCAACGAGCAGTGCCGCGTGGCCTTCGGCC
CCAAGGCTGTCGCCTGCACCTTCGCCAGGGAGCACCTGGATATGTGCCAGGCCCTCTCCTGCCACACAGACCCGCTGGACCAAAGCAGCTGCAGCCGCCT
CCTCGTTCCTCTCCTGGATGGGACAGAATGTGGCGTGGAGAAGTGGTGCTCCAAGGGTCGCTGCCGCTCCCTGGTGGAGCTGACCCCCATAGCAGCAGTG
CATGGGCGCTGGTCTAGCTGGGGTCCCCGAAGTCCTTGCTCCCGCTCCTGCGGAGGAGGTGTGGTCACCAGGAGGCGGCAGTGCAACAACCCCAGACCTG
CCTTTGGGGGGCGTGCATGTGTTGGTGCTGACCTCCAGGCCGAGATGTGCAACACTCAGGCCTGCGAGAAGACCCAGCTGGAGTTCATGTCGCAACAGTG
CGCCAGGACCGACGGCCAGCCGCTGCGCTCCTCCCCTGGCGGCGCCTCCTTCTACCACTGGGGTGCTGCTGTACCACACAGCCAAGGGGATGCTCTGTGC
AGACACATGTGCCGGGCCATTGGCGAGAGCTTCATCATGAAGCGTGGAGACAGCTTCCTCGATGGGACCCGGTGTATGCCAAGTGGCCCCCGGGAGGACG
GGACCCTGAGCCTGTGTGTGTCGGGCAGCTGCAGGACATTTGGCTGTGATGGTAGGATGGACTCCCAGCAGGTATGGGACAGGTGCCAGGTGTGTGGTGG
GGACAACAGCACGTGCAGCCCACGGAAGGGCTCTTTCACAGCTGGCAGAGCGAGAGAATATGTCACATTTCTGACAGTTACCCCCAACCTGACCAGTGTC
TACATTGCCAACCACAGGCCTCTCTTCACACACTTGGCGGTGAGGATCGGAGGGCGCTATGTCGTGGCTGGGAAGATGAGCATCTCCCCTAACACCACCT
ACCCCTCCCTCCTGGAGGATGGTCGTGTCGAGTACAGAGTGGCCCTCACCGAGGACCGGCTGCCCCGCCTGGAGGAGATCCGCATCTGGGGACCCCTCCA
GGAAGATGCTGACATCCAGGTTTACAGGCGGTATGGCGAGGAGTATGGCAACCTCACCCGCCCAGACATCACCTTCACCTACTTCCAGCCTAAGCCACGG
CAGGCCTGGGTGTGGGCCGCTGTGCGTGGGCCCTGCTCGGTGAGCTGTGGGGCAGGGCTGCGCTGGGTAAACTACAGCTGCCTGGACCAGGCCAGGAAGG
AGTTGGTGGAGACTGTCCAGTGCCAAGGGAGCCAGCAGCCACCAGCGTGGCCAGAGGCCTGCGTGCTCGAACCCTGCCCTCCCTACTGGGCGGTGGGAGA
CTTCGGCCCATGCAGCGCCTCCTGTGGGGGCGGCCTGCGGGAGCGGCCAGTGCGCTGCGTGGAGGCCCAGGGCAGCCTCCTGAAGACATTGCCCCCAGCC
CGGTGCAGAGCAGGGGCCCAGCAGCCAGCTGTGGCGCTGGAAACCTGCAACCCCCAGCCCTGCCCTGCCAGGTGGGAGGTGTCAGAGCCCAGCTCATGCA
CATCAGCTGGTGGAGCAGGCCTGGCCTTGGAGAACGAGACCTGTGTGCCAGGGGCAGATGGCCTGGAGGCTCCAGTGACTGAGGGGCCTGGCTCCGTAGA
TGAGAAGCTGCCTGCCCCTGAGCCCTGTGTCGGGATGTCATGTCCTCCAGGCTGGGGCCATCTGGATGCCACCTCTGCAGGGGAGAAGGCTCCCTCCCCA
TGGGGCAGCATCAGGACGGGGGCTCAAGCTGCACACGTGTGGACCCCTGCGGCAGGGTCGTGCTCCGTCTCCTGCGGGCGAGGTCTGATGGAGCTGCGTT
TCCTGTGCATGGACTCTGCCCTCAGGGTGCCTGTCCAGGAAGAGCTGTGTGGCCTGGCAAGCAAGCCTGGGAGCCGGCGGGAGGTCTGCCAGGCTGTCCC
GTGCCCTGCTCGGTGGCAGTACAAGCTGGCGGCCTGCAGCGTGAGCTGTGGGAGAGGGGTCGTGCGGAGGATCCTGTATTGTGCCCGGGCCCATGGGGAG
GACGATGGTGAGGAGATCCTGTTGGACACCCAGTGCCAGGGGCTGCCTCGCCCGGAACCCCAGGAGGCCTGCAGCCTGGAGCCCTGCCCACCTAGGTGGA
AAGTCATGTCCCTTGGCCCATGTTCGGCCAGCTGTGGCCTTGGCACTGCTAGACGCTCGGTGGCCTGTGTGCAGCTCGACCAAGGCCAGGACGTGGAGGT
GGACGAGGCGGCCTGTGCGGCGCTGGTGCGGCCCGAGGCCAGTGTCCCCTGTCTCATTGCCGACTGCACCTACCGCTGGCATGTTGGCACCTGGATGGAG
TGCTCTGTTTCCTGTGGGGATGGCATCCAGCGCCGGCGTGACACCTGCCTCGGACCCCAGGCCCAGGCGCCTGTGCCAGCTGATTTCTGCCAGCACTTGC
CCAAGCCGGTGACTGTGCGTGGCTGCTGGGCTGGGCCCTGTGTGGGACAGGGTGCCTGTGGCAGGCAGCACCTTGAGCCAACAGGAACCATTGACATGCG
AGG
CCCAGGGCAGGCAGACTGTGCAGTGGCCATTGGGCGGCCCCTCGGGGAGGTGGTGACCCTCCGCGTCCTTGAGAGTTCTCTCAACTGCAGTGCGGGG
GACATGTTGCTGCTTTGGGGCCGGCTCACCTGGAGGAAGATGTGCAGGAAGCTGTTGGACATGACTTTCAGCTCCAAGACCAACACGCTGGTGGTGAGGC
AGCGCTGCGGGCGGCCAGGAGGTGGGGTGCTGCTGCGGTATGGGAGCCAGCTTGCTCCTGAAACCTTCTACAGAGAATGTGACATGCAGCTCTTTGGGCC
CTGGGGTGAAATCGTGAGCCCCTCGCTGAGTCCAGCCACGAGTAATGCAGGGGGCTGCCGGCTCTTCATTAATGTGGCTCCGCACGCACGGATTGCCATC
CATGCCCTGGCCACCAACATGGGCGCTGGGACCGAGGGAGCCAATGCCAGCTACATCTTGATCCGGGACACCCACAGCTTGAGGACCACAGCGTTCCATG
GGCAGCAGGTGCTCTACTGGGAGTCAGAGAGCAGCCAGGCTGAGATGGAGTTCAGCGAGGGCTTCCTGAAGGCTCAGGCCAGCCTGCGGGGCCAGTACTG
GACCCTCCAATCATGGGTACCGGAGATGCAGGACCCTCAGTCCTGGAAGGGAAAGGAAGGAACCTGAGGGTCATTGAACATTTGTTCCGTGTCTGGCCAG
CCCTGGAGGGTTGACCCCTGGTCTCAGTGCTTTCCAATTCGAACTTTTTCCAATCTTAGGTATCTACTTTAGAGTCTTCTCCAATGTCCAAAAGGCTAGG
GGGTTGGAGGTGGGGACTCTGGAAAAGCAGCCCCCATTTCCTCGGGTACCAATAAATAAAACATGCAGGCTG
  • refseq_ADAMTS13.F2 (forward primer)
  • refseq_ADAMTS13.R2 (reverse primer)
  • Alternative donor

Frame 0

NHDVFGTASHLSDGSGDPGEGVSRGPGIPCEPP
SVGFWSSVPSPD*MA*ASSKGVGVHIRRAVWCAG
LGCRLP*TATILEQGPACSRRSCRPPTLATAPA
LAGSFQE*TLPNRPAQ**AGLSHSILTRFPVTK
APSHSAPLLGLALLRMHQRHPRARCPPLCVAGIL
ACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSP
GAPLKGRPPSPGFQRQRQRQRRAAGGILHLELL
VAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS
LGAQFRVHLVKMVILTEPEGAPNITANLTSSLL
SVCGWSQTINPEDDTDPGHADLVLYITRFDLEL
PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLG
VTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASD
GAAPRAGLAWSPCSRRQLLSLLSANEQCRVAFG
PKAVACTFAREHLDMCQALSCHTDPLDQSSCSRL
LVPLLDGTECGVEKWCSKGRCRSLVELTPIAAV
HGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRP
AFGGRACVGADLQAEMCNTQACEKTQLEFMSQQC
ARTDGQPLRSSPGGASFYHWGAAVPHSQGDALC
RHMCRAIGESFIMKRGDSFLDGTRCMPSGPRED
GTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGG
DNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSV
YIANHRPLFTHLAVRIGGRYVVAGKMSISPNTT
YPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQ
EDADIQVYRRYGEEYGNLTRPDITFTYFQPKPR
QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK
ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGD
FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPA
RCRAGAQQPAVALETCNPQPCPARWEVSEPSSC
TSAGGAGLALENETCVPGADGLEAPVTEGPGSVD
EKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSP
WGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELR
FLCMDSALRVPVQEELCGLASKPGSRREVCQAVP
CPARWQYKLAACSVSCGRGVVRRILYCARAHGE
DDGEEILLDTQCQGLPRPEPQEACSLEPCPPRW
KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEV
DEAACAALVRPEASVPCLIADCTYRWHVGTWME
CSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL
PKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMR
G
PGQADCAVAIGRPLGEVVTLRVLESSLNCSAG
DMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVR
QRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGP
WGEIVSPSLSPATSNAGGCRLFINVAPHARIAI
HALATNMGAGTEGANASYILIRDTHSLRTTAFH
GQQVLYWESESSQAEMEFSEGFLKAQASLRGQYW
TLQSWVPEMQDPQSWKGKEGT*GSLNICSVSGQ
PWRVDPWSQCFPIRTFSNLRYLL*SLLQCPKG*
GVGGGDSGKAAPISSGTNK*NMQA

Frame 1

TTMSLAQPLICQMGAGTPERESAEVLAFLVNPR
LWVSGPVSLLQIRWLRPPLRGWACTSGELSGVQ
DWAAGYPELQPS*SKAQLAAGGAAGRPP*PRPLP
WQEASKSKHCLIVPPSSEQACPIPY*PDSQSPR
PPLTPLHSSGWLS*GCTSVTPGQDALPSVWPES
LPVAFSWAAGDPPISSRVVFRLWSHRPCLLT*AL
VLP*KAALLPLASRGRGRGRGGLQAASYTWSCW
WPWAPMSSRLTRRTQSAMCSPTSTSGQNCFGTR
PWGLSFGCTW*RWSF*QSLRVPQISQPTSPRPC*
ASVGGARPSTLRTTRILAMLTWSSISLGLTWSC
LMVTGRCGASPSWAVPAPQPGAASLPRTLASTW
ESPLPMRLGTASAWSTTARPAAAAAPADT*WLRT
APRPAPASPGPPAAAGSC*ACSAPTSSAAWPSA
PRLSPAPSPGSTWICARPSPATQTRWTKAAAAA
SSFLSWMGQNVAWRSGAPRVAAAPWWS*PP*QQC
MGAGLAGVPEVLAPAPAEEVWSPGGGSATTPDL
PLGGVHVLVLTSRPRCATLRPARRPSWSSCRNS
APGPTASRCAPPLAAPPSTTGVLLYHTAKGMLCA
DTCAGPLARASS*SVETASSMGPGVCQVAPGRT
GP*ACVCRAAAGHLAVMVGWTPSRYGTGARCVV
GTTARAAHGRALSQLAERENMSHF*QLPPT*PVS
TLPTTGLSSHTWR*GSEGAMSWLGR*ASPLTPP
TPPSWRMVVSSTEWPSPRTGCPAWRRSASGDPS
RKMLTSRFTGGMARSMATSPAQTSPSPTSSLSHG
RPGCGPLCVGPAR*AVGQGCAG*TTAAWTRPGR
SWWRLSSAKGASSHQRGQRPACSNPALPTGRWE
TSAHAAPPVGAACGSGQCAAWRPRAAS*RHCPQP
GAEQGPSSQLWRWKPATPSPALPGGRCQSPAHA
HQLVEQAWPWRTRPVCQGQMAWRLQ*LRGLAP*
MRSCLPLSPVSGCHVLQAGAIWMPPLQGRRLPPH
GAASGRGLKLHTCGPLRQGRAPSPAGEV*WSCV
SCAWTLPSGCLSRKSCVAWQASLGAGGRSARLS
RALLGGSTSWRPAA*AVGEGSCGGSCIVPGPMGR
TMVRRSCWTPSARGCLARNPRRPAAWSPAHLGG
KSCPLAHVRPAVALALLDARWPVCSSTKARTWR
WTRRPVRRWCGPRPVSPVSLPTAPTAGMLAPGWS
ALFPVGMASSAGVTPASDPRPRRLCQLISASTC
PSR*LCVAAGLGPVWDRVPVAGSTLSQQEPLTC
E
AQGRQTVQWPLGGPSGRW*PSASLRVLSTAVRG
TCCCFGAGSPGGRCAGSCWT*LSAPRPTRWW*G
SAAGGQEVGCCCGMGASLLLKPSTENVTCSSLG
PGVKS*APR*VQPRVMQGAAGSSLMWLRTHGLPS
MPWPPTWALGPREPMPATS*SGTPTA*GPQRSM
GSRCSTGSQRAARLRWSSARAS*RLRPACGAST
GPSNHGYRRCRTLSPGRERKEPEGH*TFVPCLAS
PGGLTPGLSAFQFELFPILGIYFRVFSNVQKAR
GLEVGTLEKQPPFPRVPINKTCRL

Frame 2

PRCLWHSLSSVRWERGPRRGSQPRSWHSL*TPV
CGFLVQCPFSRLDGLGLL*GGGRAHPESCLVCR
TGLQVTLNCNHLRARPSLQQEELQAAHPSHGPC
PGRKLPRVNTA*SSRPVVSRPVPFHTDQIPSHQG
PLSLRSTPRAGSPEDAPASPPGKMPSPLCGRNP
CLWLSPGLLGTLPFPAELSSGFGATGRVFLLEP
WCSLKRPPSFPWLPEAEAEAEAGCRRHPTPGAAG
GRGPRCLPGSPGGHRALCAHQPQHRGRTASGPV
PGGSVSGAPGEDGHSDRA*GCPKYHSQPHLVPA
ERLWVEPDHQP*GRHGSWPC*PGPLYH*V*PGVA
*W*PAGAGRHPAGRCLLPNLELPHYRGHWLRPG
SHHCP*DWAQLRPGARRRARQRLRPQRTRDGFG
RRRAPRRPRLVPLQPPAAAEPAQRQRAVPRGLRP
QGCRLHLRQGAPGYVPGPLLPHRPAGPKQLQPP
PRSSPGWDRMWRGEVVLQGSLPLPGGADPHSSS
AWALV*LGSPKSLLPLLRRRCGHQEAAVQQPQTC
LWGACMCWC*PPGRDVQHSGLREDPAGVHVATV
RQDRRPAAALLPWRRLLLPLGCCCTTQPRGCSV
QTHVPGHWRELHHEAWRQLPRWDPVYAKWPPGGR
DPEPVCVGQLQDIWL*W*DGLPAGMGQVPGVWW
GQQHVQPTEGLFHSWQSERICHISDSYPQPDQC
LHCQPQASLHTLGGEDRRALCRGWEDEHLP*HHL
PLPPGGWSCRVQSGPHRGPAAPPGGDPHLGTPP
GRC*HPGLQAVWRGVWQPHPPRHHLHLLPA*AT
AGLGVGRCAWALLGELWGRAALGKLQLPGPGQEG
VGGDCPVPREPAATSVARGLRARTLPSLLGGGR
LRPMQRLLWGRPAGAASALRGGPGQPPEDIAPS
PVQSRGPAASCGAGNLQPPALPCQVGGVRAQLMH
ISWWSRPGLGERDLCARGRWPGGSSD*GAWLRR
*EAACP*ALCRDVMSSRLGPSGCHLCRGEGSLP
MGQHQDGGSSCTRVDPCGRVVLRLLRARSDGAAF
PVHGLCPQGACPGRAVWPGKQAWEPAGGLPGCP
VPCSVAVQAGGLQRELWERGRAEDPVLCPGPWG
GRW*GDPVGHPVPGAASPGTPGGLQPGALPT*VE
SHVPWPMFGQLWPWHC*TLGGLCAARPRPGRGG
GRGGLCGAGAARGQCPLSHCRLHLPLACWHLDG
VLCFLWGWHPAPA*HLPRTPGPGACAS*FLPALA
QAGDCAWLLGWALCGTGCLWQAAP*ANRNH*HA
R
PRAGRLCSGHWAAPRGGGDPPRP*EFSQLQCG
GHVAALGPAHLEEDVQEAVGHDFQLQDQHAGGEA
ALRAARRWGAAAVWEPACS*NLLQRM*HAALWA
LG*NREPLAESSHE*CRGLPALH*CGSARTDCH
PCPGHQHGRWDRGSQCQLHLDPGHPQLEDHSVPW
AAGALLGVREQPG*DGVQRGLPEGSGQPAGPVL
DPPIMGTGDAGPSVLEGKGRNLRVIEHLFRVWP
ALEG*PLVSVLSNSNFFQS*VSTLESSPMSKRLG
GWRWGLWKSSPHFLGYQ*IKHAG

Sequence NM_139027

AACCACGATGTCTTTGGCACAGCCTCTCATCTGTCAGATGGGAGCGGGGACCCCGGAGAGGGAGTCAGCCGAGGTCCTGGCATTCCTTGTGAACCCCCGT
CTGTGGGTTTCTGGTCCAGTGTCCCTTCTCCAGATTAGATGGCTTAGGCCTCCTCTAAGGGGGTGGGCGTGCACATCCGGAGAGCTGTCTGGTGTGCAGG
ACTGGGCTGCAGGTTACCCTGAACTGCAACCATCTTAGAGCAAGGCCCAGCTTGCAGCAGGAGGAGCTGCAGGCCGCCCACCCTAGCCACGGCCCCTGCC
CTGGCAGGAAGCTTCCAAGAGTAAACACTGCCTAATCGTCCCGCCCAGTAGTGAGCAGGCCTGTCCCATTCCATACTGACCAGATTCCCAGTCACCAAGG
CCCCCTCTCACTCCGCTCCACTCCTCGGGCTGGCTCTCCTGAGGATGCACCAGCGTCACCCCCGGGCAAGATGCCCTCCCCTCTGTGTGGCCGGAATCCT
TGCCTGTGGCTTTCTCCTGGGCTGCTGGGGACCCTCCCATTTCCAGCAGAGTTGTCTTCAGGCTTTGGAGCCACAGGCCGTGTCTTCTTACTTGAGCCCT
GGTGCTCCCTTAAAAGGCCGCCCTCCTTCCCCTGGCTTCCAGAGGCAGAGGCAGAGGCAGAGGCGGGCTGCAGGCGGCATCCTACACCTGGAGCTGCTGG
TGGCCGTGGGCCCCGATGTCTTCCAGGCTCACCAGGAGGACACAGAGCGCTATGTGCTCACCAACCTCAACATCGGGGCAGAACTGCTTCGGGACCCGTC
CCTGGGGGCTCAGTTTCGGGTGCACCTGGTGAAGATGGTCATTCTGACAGAGCCTGAGGGTGCCCCAAATATCACAGCCAACCTCACCTCGTCCCTGCTG
AGCGTCTGTGGGTGGAGCCAGACCATCAACCCTGAGGACGACACGGATCCTGGCCATGCTGACCTGGTCCTCTATATCACTAGGTTTGACCTGGAGTTGC
CTGATGGTAACCGGCAGGTGCGGGGCGTCACCCAGCTGGGCGGTGCCTGCTCCCCAACCTGGAGCTGCCTCATTACCGAGGACACTGGCTTCGACCTGGG
AGTCACCATTGCCCATGAGATTGGGCACAGCTTCGGCCTGGAGCACGACGGCGCGCCCGGCAGCGGCTGCGGCCCCAGCGGACACGTGATGGCTTCGGAC
GGCGCCGCGCCCCGCGCCGGCCTCGCCTGGTCCCCCTGCAGCCGCCGGCAGCTGCTGAGCCTGCTCAGCGCAGGACGGGCGCGCTGCGTGTGGGACCCGC
CGCGGCCTCAACCCGGGTCCGCGGGGCACCCGCCGGATGCGCAGCCTGGCCTCTACTACAGCGCCAACGAGCAGTGCCGCGTGGCCTTCGGCCCCAAGGC
TGTCGCCTGCACCTTCGCCAGGGAGCACCTGGATATGTGCCAGGCCCTCTCCTGCCACACAGACCCGCTGGACCAAAGCAGCTGCAGCCGCCTCCTCGTT
CCTCTCCTGGATGGGACAGAATGTGGCGTGGAGAAGTGGTGCTCCAAGGGTCGCTGCCGCTCCCTGGTGGAGCTGACCCCCATAGCAGCAGTGCATGGGC
GCTGGTCTAGCTGGGGTCCCCGAAGTCCTTGCTCCCGCTCCTGCGGAGGAGGTGTGGTCACCAGGAGGCGGCAGTGCAACAACCCCAGACCTGCCTTTGG
GGGGCGTGCATGTGTTGGTGCTGACCTCCAGGCCGAGATGTGCAACACTCAGGCCTGCGAGAAGACCCAGCTGGAGTTCATGTCGCAACAGTGCGCCAGG
ACCGACGGCCAGCCGCTGCGCTCCTCCCCTGGCGGCGCCTCCTTCTACCACTGGGGTGCTGCTGTACCACACAGCCAAGGGGATGCTCTGTGCAGACACA
TGTGCCGGGCCATTGGCGAGAGCTTCATCATGAAGCGTGGAGACAGCTTCCTCGATGGGACCCGGTGTATGCCAAGTGGCCCCCGGGAGGACGGGACCCT
GAGCCTGTGTGTGTCGGGCAGCTGCAGGACATTTGGCTGTGATGGTAGGATGGACTCCCAGCAGGTATGGGACAGGTGCCAGGTGTGTGGTGGGGACAAC
AGCACGTGCAGCCCACGGAAGGGCTCTTTCACAGCTGGCAGAGCGAGAGAATATGTCACATTTCTGACAGTTACCCCCAACCTGACCAGTGTCTACATTG
CCAACCACAGGCCTCTCTTCACACACTTGGCGGTGAGGATCGGAGGGCGCTATGTCGTGGCTGGGAAGATGAGCATCTCCCCTAACACCACCTACCCCTC
CCTCCTGGAGGATGGTCGTGTCGAGTACAGAGTGGCCCTCACCGAGGACCGGCTGCCCCGCCTGGAGGAGATCCGCATCTGGGGACCCCTCCAGGAAGAT
GCTGACATCCAGGTTTACAGGCGGTATGGCGAGGAGTATGGCAACCTCACCCGCCCAGACATCACCTTCACCTACTTCCAGCCTAAGCCACGGCAGGCCT
GGGTGTGGGCCGCTGTGCGTGGGCCCTGCTCGGTGAGCTGTGGGGCAGGGCTGCGCTGGGTAAACTACAGCTGCCTGGACCAGGCCAGGAAGGAGTTGGT
GGAGACTGTCCAGTGCCAAGGGAGCCAGCAGCCACCAGCGTGGCCAGAGGCCTGCGTGCTCGAACCCTGCCCTCCCTACTGGGCGGTGGGAGACTTCGGC
CCATGCAGCGCCTCCTGTGGGGGCGGCCTGCGGGAGCGGCCAGTGCGCTGCGTGGAGGCCCAGGGCAGCCTCCTGAAGACATTGCCCCCAGCCCGGTGCA
GAGCAGGGGCCCAGCAGCCAGCTGTGGCGCTGGAAACCTGCAACCCCCAGCCCTGCCCTGCCAGGTGGGAGGTGTCAGAGCCCAGCTCATGCACATCAGC
TGGTGGAGCAGGCCTGGCCTTGGAGAACGAGACCTGTGTGCCAGGGGCAGATGGCCTGGAGGCTCCAGTGACTGAGGGGCCTGGCTCCGTAGATGAGAAG
CTGCCTGCCCCTGAGCCCTGTGTCGGGATGTCATGTCCTCCAGGCTGGGGCCATCTGGATGCCACCTCTGCAGGGGAGAAGGCTCCCTCCCCATGGGGCA
GCATCAGGACGGGGGCTCAAGCTGCACACGTGTGGACCCCTGCGGCAGGGTCGTGCTCCGTCTCCTGCGGGCGAGGTCTGATGGAGCTGCGTTTCCTGTG
CATGGACTCTGCCCTCAGGGTGCCTGTCCAGGAAGAGCTGTGTGGCCTGGCAAGCAAGCCTGGGAGCCGGCGGGAGGTCTGCCAGGCTGTCCCGTGCCCT
GCTCGGTGGCAGTACAAGCTGGCGGCCTGCAGCGTGAGCTGTGGGAGAGGGGTCGTGCGGAGGATCCTGTATTGTGCCCGGGCCCATGGGGAGGACGATG
GTGAGGAGATCCTGTTGGACACCCAGTGCCAGGGGCTGCCTCGCCCGGAACCCCAGGAGGCCTGCAGCCTGGAGCCCTGCCCACCTAGGTGGAAAGTCAT
GTCCCTTGGCCCATGTTCGGCCAGCTGTGGCCTTGGCACTGCTAGACGCTCGGTGGCCTGTGTGCAGCTCGACCAAGGCCAGGACGTGGAGGTGGACGAG
GCGGCCTGTGCGGCGCTGGTGCGGCCCGAGGCCAGTGTCCCCTGTCTCATTGCCGACTGCACCTACCGCTGGCATGTTGGCACCTGGATGGAGTGCTCTG
TTTCCTGTGGGGATGGCATCCAGCGCCGGCGTGACACCTGCCTCGGACCCCAGGCCCAGGCGCCTGTGCCAGCTGATTTCTGCCAGCACTTGCCCAAGCC
GGTGACTGTGCGTGGCTGCTGGGCTGGGCCCTGTGTGGGACAGGGTGCCTGTGGCAGGCAGCACCTTGAGCCAACAGGAACCATTGACATGCGAGGCCCA
GGGCAGGCAGACTGTGCAGTGGCCATTGGGCGGCCCCTCGGGGAGGTGGTGACCCTCCGCGTCCTTGAGAGTTCTCTCAACTGCAGTGCGGGGGACATGT
TGCTGCTTTGGGGCCGGCTCACCTGGAGGAAGATGTGCAGGAAGCTGTTGGACATGACTTTCAGCTCCAAGACCAACACGCTGGTGGTGAGGCAGCGCTG
CGGGCGGCCAGGAGGTGGGGTGCTGCTGCGGTATGGGAGCCAGCTTGCTCCTGAAACCTTCTACAGAGAATGTGACATGCAGCTCTTTGGGCCCTGGGGT
GAAATCGTGAGCCCCTCGCTGAGTCCAGCCACGAGTAATGCAGGGGGCTGCCGGCTCTTCATTAATGTGGCTCCGCACGCACGGATTGCCATCCATGCCC
TGGCCACCAACATGGGCGCTGGGACCGAGGGAGCCAATGCCAGCTACATCTTGATCCGGGACACCCACAGCTTGAGGACCACAGCGTTCCATGGGCAGCA
GGTGCTCTACTGGGAGTCAGAGAGCAGCCAGGCTGAGATGGAGTTCAGCGAGGGCTTCCTGAAGGCTCAGGCCAGCCTGCGGGGCCAGTACTGGACCCTC
CAATCATGGGTACCGGAGATGCAGGACCCTCAGTCCTGGAAGGGAAAGGAAGGAACCTGAGGGTCATTGAACATTTGTTCCGTGTCTGGCCAGCCCTGGA
GGGTTGACCCCTGGTCTCAGTGCTTTCCAATTCGAACTTTTTCCAATCTTAGGTATCTACTTTAGAGTCTTCTCCAATGTCCAAAAGGCTAGGGGGTTGG
AGGTGGGGACTCTGGAAAAGCAGCCCCCATTTCCTCGGGTACCAATAAATAAAACATGCAGGCTG
  • refseq_ADAMTS13.F2 (forward primer)
  • refseq_ADAMTS13.R2 (reverse primer)
  • Alternative donor

Frame 0

NHDVFGTASHLSDGSGDPGEGVSRGPGIPCEPP
SVGFWSSVPSPD*MA*ASSKGVGVHIRRAVWCAG
LGCRLP*TATILEQGPACSRRSCRPPTLATAPA
LAGSFQE*TLPNRPAQ**AGLSHSILTRFPVTK
APSHSAPLLGLALLRMHQRHPRARCPPLCVAGIL
ACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSP
GAPLKGRPPSPGFQRQRQRQRRAAGGILHLELL
VAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS
LGAQFRVHLVKMVILTEPEGAPNITANLTSSLL
SVCGWSQTINPEDDTDPGHADLVLYITRFDLEL
PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLG
VTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASD
GAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDP
PRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKA
VACTFAREHLDMCQALSCHTDPLDQSSCSRLLV
PLLDGTECGVEKWCSKGRCRSLVELTPIAAVHG
RWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG
GRACVGADLQAEMCNTQACEKTQLEFMSQQCAR
TDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH
MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTL
SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDN
STCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI
ANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPS
LLEDGRVEYRVALTEDRLPRLEEIRIWGPLQED
ADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQA
WVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELV
ETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG
PCSASCGGGLRERPVRCVEAQGSLLKTLPPARC
RAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA
GGAGLALENETCVPGADGLEAPVTEGPGSVDEK
LPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG
SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLC
MDSALRVPVQEELCGLASKPGSRREVCQAVPCP
ARWQYKLAACSVSCGRGVVRRILYCARAHGEDD
GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM
SLGPCSASCGLGTARRSVACVQLDQGQDVEVDE
AACAALVRPEASVPCLIADCTYRWHVGTWMECS
VSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP
VTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGP
GQADCAVAIGRPLGEVVTLRVLESSLNCSAGDM
LLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRC
GRPGGGVLLRYGSQLAPETFYRECDMQLFGPWG
EIVSPSLSPATSNAGGCRLFINVAPHARIAIHA
LATNMGAGTEGANASYILIRDTHSLRTTAFHGQQ
VLYWESESSQAEMEFSEGFLKAQASLRGQYWTL
QSWVPEMQDPQSWKGKEGT*GSLNICSVSGQPW
RVDPWSQCFPIRTFSNLRYLL*SLLQCPKG*GVG
GGDSGKAAPISSGTNK*NMQA

Frame 1

TTMSLAQPLICQMGAGTPERESAEVLAFLVNPR
LWVSGPVSLLQIRWLRPPLRGWACTSGELSGVQ
DWAAGYPELQPS*SKAQLAAGGAAGRPP*PRPLP
WQEASKSKHCLIVPPSSEQACPIPY*PDSQSPR
PPLTPLHSSGWLS*GCTSVTPGQDALPSVWPES
LPVAFSWAAGDPPISSRVVFRLWSHRPCLLT*AL
VLP*KAALLPLASRGRGRGRGGLQAASYTWSCW
WPWAPMSSRLTRRTQSAMCSPTSTSGQNCFGTR
PWGLSFGCTW*RWSF*QSLRVPQISQPTSPRPC*
ASVGGARPSTLRTTRILAMLTWSSISLGLTWSC
LMVTGRCGASPSWAVPAPQPGAASLPRTLASTW
ESPLPMRLGTASAWSTTARPAAAAAPADT*WLRT
APRPAPASPGPPAAAGSC*ACSAQDGRAACGTR
RGLNPGPRGTRRMRSLASTTAPTSSAAWPSAPR
LSPAPSPGSTWICARPSPATQTRWTKAAAAASSF
LSWMGQNVAWRSGAPRVAAAPWWS*PP*QQCMG
AGLAGVPEVLAPAPAEEVWSPGGGSATTPDLPL
GGVHVLVLTSRPRCATLRPARRPSWSSCRNSAPG
PTASRCAPPLAAPPSTTGVLLYHTAKGMLCADT
CAGPLARASS*SVETASSMGPGVCQVAPGRTGP
*ACVCRAAAGHLAVMVGWTPSRYGTGARCVVGTT
ARAAHGRALSQLAERENMSHF*QLPPT*PVSTL
PTTGLSSHTWR*GSEGAMSWLGR*ASPLTPPTP
PSWRMVVSSTEWPSPRTGCPAWRRSASGDPSRKM
LTSRFTGGMARSMATSPAQTSPSPTSSLSHGRP
GCGPLCVGPAR*AVGQGCAG*TTAAWTRPGRSW
WRLSSAKGASSHQRGQRPACSNPALPTGRWETSA
HAAPPVGAACGSGQCAAWRPRAAS*RHCPQPGA
EQGPSSQLWRWKPATPSPALPGGRCQSPAHAHQ
LVEQAWPWRTRPVCQGQMAWRLQ*LRGLAP*MRS
CLPLSPVSGCHVLQAGAIWMPPLQGRRLPPHGA
ASGRGLKLHTCGPLRQGRAPSPAGEV*WSCVSC
AWTLPSGCLSRKSCVAWQASLGAGGRSARLSRAL
LGGSTSWRPAA*AVGEGSCGGSCIVPGPMGRTM
VRRSCWTPSARGCLARNPRRPAAWSPAHLGGKS
CPLAHVRPAVALALLDARWPVCSSTKARTWRWTR
RPVRRWCGPRPVSPVSLPTAPTAGMLAPGWSAL
FPVGMASSAGVTPASDPRPRRLCQLISASTCPS
R*LCVAAGLGPVWDRVPVAGSTLSQQEPLTCEAQ
GRQTVQWPLGGPSGRW*PSASLRVLSTAVRGTC
CCFGAGSPGGRCAGSCWT*LSAPRPTRWW*GSA
AGGQEVGCCCGMGASLLLKPSTENVTCSSLGPGV
KS*APR*VQPRVMQGAAGSSLMWLRTHGLPSMP
WPPTWALGPREPMPATS*SGTPTA*GPQRSMGS
RCSTGSQRAARLRWSSARAS*RLRPACGASTGPS
NHGYRRCRTLSPGRERKEPEGH*TFVPCLASPG
GLTPGLSAFQFELFPILGIYFRVFSNVQKARGL
EVGTLEKQPPFPRVPINKTCRL

Frame 2

PRCLWHSLSSVRWERGPRRGSQPRSWHSL*TPV
CGFLVQCPFSRLDGLGLL*GGGRAHPESCLVCR
TGLQVTLNCNHLRARPSLQQEELQAAHPSHGPC
PGRKLPRVNTA*SSRPVVSRPVPFHTDQIPSHQG
PLSLRSTPRAGSPEDAPASPPGKMPSPLCGRNP
CLWLSPGLLGTLPFPAELSSGFGATGRVFLLEP
WCSLKRPPSFPWLPEAEAEAEAGCRRHPTPGAAG
GRGPRCLPGSPGGHRALCAHQPQHRGRTASGPV
PGGSVSGAPGEDGHSDRA*GCPKYHSQPHLVPA
ERLWVEPDHQP*GRHGSWPC*PGPLYH*V*PGVA
*W*PAGAGRHPAGRCLLPNLELPHYRGHWLRPG
SHHCP*DWAQLRPGARRRARQRLRPQRTRDGFG
RRRAPRRPRLVPLQPPAAAEPAQRRTGALRVGPA
AASTRVRGAPAGCAAWPLLQRQRAVPRGLRPQG
CRLHLRQGAPGYVPGPLLPHRPAGPKQLQPPPR
SSPGWDRMWRGEVVLQGSLPLPGGADPHSSSAWA
LV*LGSPKSLLPLLRRRCGHQEAAVQQPQTCLW
GACMCWC*PPGRDVQHSGLREDPAGVHVATVRQ
DRRPAAALLPWRRLLLPLGCCCTTQPRGCSVQTH
VPGHWRELHHEAWRQLPRWDPVYAKWPPGGRDP
EPVCVGQLQDIWL*W*DGLPAGMGQVPGVWWGQ
QHVQPTEGLFHSWQSERICHISDSYPQPDQCLHC
QPQASLHTLGGEDRRALCRGWEDEHLP*HHLPL
PPGGWSCRVQSGPHRGPAAPPGGDPHLGTPPGR
C*HPGLQAVWRGVWQPHPPRHHLHLLPA*ATAGL
GVGRCAWALLGELWGRAALGKLQLPGPGQEGVG
GDCPVPREPAATSVARGLRARTLPSLLGGGRLR
PMQRLLWGRPAGAASALRGGPGQPPEDIAPSPVQ
SRGPAASCGAGNLQPPALPCQVGGVRAQLMHIS
WWSRPGLGERDLCARGRWPGGSSD*GAWLRR*E
AACP*ALCRDVMSSRLGPSGCHLCRGEGSLPMGQ
HQDGGSSCTRVDPCGRVVLRLLRARSDGAAFPV
HGLCPQGACPGRAVWPGKQAWEPAGGLPGCPVP
CSVAVQAGGLQRELWERGRAEDPVLCPGPWGGRW
*GDPVGHPVPGAASPGTPGGLQPGALPT*VESH
VPWPMFGQLWPWHC*TLGGLCAARPRPGRGGGR
GGLCGAGAARGQCPLSHCRLHLPLACWHLDGVLC
FLWGWHPAPA*HLPRTPGPGACAS*FLPALAQA
GDCAWLLGWALCGTGCLWQAAP*ANRNH*HARP
RAGRLCSGHWAAPRGGGDPPRP*EFSQLQCGGHV
AALGPAHLEEDVQEAVGHDFQLQDQHAGGEAAL
RAARRWGAAAVWEPACS*NLLQRM*HAALWALG
*NREPLAESSHE*CRGLPALH*CGSARTDCHPCP
GHQHGRWDRGSQCQLHLDPGHPQLEDHSVPWAA
GALLGVREQPG*DGVQRGLPEGSGQPAGPVLDP
PIMGTGDAGPSVLEGKGRNLRVIEHLFRVWPALE
G*PLVSVLSNSNFFQS*VSTLESSPMSKRLGGW
RWGLWKSSPHFLGYQ*IKHAG

Sequence NM_139025

AACCACGATGTCTTTGGCACAGCCTCTCATCTGTCAGATGGGAGCGGGGACCCCGGAGAGGGAGTCAGCCGAGGTCCTGGCATTCCTTGTGAACCCCCGT
CTGTGGGTTTCTGGTCCAGTGTCCCTTCTCCAGATTAGATGGCTTAGGCCTCCTCTAAGGGGGTGGGCGTGCACATCCGGAGAGCTGTCTGGTGTGCAGG
ACTGGGCTGCAGGTTACCCTGAACTGCAACCATCTTAGAGCAAGGCCCAGCTTGCAGCAGGAGGAGCTGCAGGCCGCCCACCCTAGCCACGGCCCCTGCC
CTGGCAGGAAGCTTCCAAGAGTAAACACTGCCTAATCGTCCCGCCCAGTAGTGAGCAGGCCTGTCCCATTCCATACTGACCAGATTCCCAGTCACCAAGG
CCCCCTCTCACTCCGCTCCACTCCTCGGGCTGGCTCTCCTGAGGATGCACCAGCGTCACCCCCGGGCAAGATGCCCTCCCCTCTGTGTGGCCGGAATCCT
TGCCTGTGGCTTTCTCCTGGGCTGCTGGGGACCCTCCCATTTCCAGCAGAGTTGTCTTCAGGCTTTGGAGCCACAGGCCGTGTCTTCTTACTTGAGCCCT
GGTGCTCCCTTAAAAGGCCGCCCTCCTTCCCCTGGCTTCCAGAGGCAGAGGCAGAGGCAGAGGCGGGCTGCAGGCGGCATCCTACACCTGGAGCTGCTGG
TGGCCGTGGGCCCCGATGTCTTCCAGGCTCACCAGGAGGACACAGAGCGCTATGTGCTCACCAACCTCAACATCGGGGCAGAACTGCTTCGGGACCCGTC
CCTGGGGGCTCAGTTTCGGGTGCACCTGGTGAAGATGGTCATTCTGACAGAGCCTGAGGGTGCCCCAAATATCACAGCCAACCTCACCTCGTCCCTGCTG
AGCGTCTGTGGGTGGAGCCAGACCATCAACCCTGAGGACGACACGGATCCTGGCCATGCTGACCTGGTCCTCTATATCACTAGGTTTGACCTGGAGTTGC
CTGATGGTAACCGGCAGGTGCGGGGCGTCACCCAGCTGGGCGGTGCCTGCTCCCCAACCTGGAGCTGCCTCATTACCGAGGACACTGGCTTCGACCTGGG
AGTCACCATTGCCCATGAGATTGGGCACAGCTTCGGCCTGGAGCACGACGGCGCGCCCGGCAGCGGCTGCGGCCCCAGCGGACACGTGATGGCTTCGGAC
GGCGCCGCGCCCCGCGCCGGCCTCGCCTGGTCCCCCTGCAGCCGCCGGCAGCTGCTGAGCCTGCTCAGCGCAGGACGGGCGCGCTGCGTGTGGGACCCGC
CGCGGCCTCAACCCGGGTCCGCGGGGCACCCGCCGGATGCGCAGCCTGGCCTCTACTACAGCGCCAACGAGCAGTGCCGCGTGGCCTTCGGCCCCAAGGC
TGTCGCCTGCACCTTCGCCAGGGAGCACCTGGATATGTGCCAGGCCCTCTCCTGCCACACAGACCCGCTGGACCAAAGCAGCTGCAGCCGCCTCCTCGTT
CCTCTCCTGGATGGGACAGAATGTGGCGTGGAGAAGTGGTGCTCCAAGGGTCGCTGCCGCTCCCTGGTGGAGCTGACCCCCATAGCAGCAGTGCATGGGC
GCTGGTCTAGCTGGGGTCCCCGAAGTCCTTGCTCCCGCTCCTGCGGAGGAGGTGTGGTCACCAGGAGGCGGCAGTGCAACAACCCCAGACCTGCCTTTGG
GGGGCGTGCATGTGTTGGTGCTGACCTCCAGGCCGAGATGTGCAACACTCAGGCCTGCGAGAAGACCCAGCTGGAGTTCATGTCGCAACAGTGCGCCAGG
ACCGACGGCCAGCCGCTGCGCTCCTCCCCTGGCGGCGCCTCCTTCTACCACTGGGGTGCTGCTGTACCACACAGCCAAGGGGATGCTCTGTGCAGACACA
TGTGCCGGGCCATTGGCGAGAGCTTCATCATGAAGCGTGGAGACAGCTTCCTCGATGGGACCCGGTGTATGCCAAGTGGCCCCCGGGAGGACGGGACCCT
GAGCCTGTGTGTGTCGGGCAGCTGCAGGACATTTGGCTGTGATGGTAGGATGGACTCCCAGCAGGTATGGGACAGGTGCCAGGTGTGTGGTGGGGACAAC
AGCACGTGCAGCCCACGGAAGGGCTCTTTCACAGCTGGCAGAGCGAGAGAATATGTCACATTTCTGACAGTTACCCCCAACCTGACCAGTGTCTACATTG
CCAACCACAGGCCTCTCTTCACACACTTGGCGGTGAGGATCGGAGGGCGCTATGTCGTGGCTGGGAAGATGAGCATCTCCCCTAACACCACCTACCCCTC
CCTCCTGGAGGATGGTCGTGTCGAGTACAGAGTGGCCCTCACCGAGGACCGGCTGCCCCGCCTGGAGGAGATCCGCATCTGGGGACCCCTCCAGGAAGAT
GCTGACATCCAGGTTTACAGGCGGTATGGCGAGGAGTATGGCAACCTCACCCGCCCAGACATCACCTTCACCTACTTCCAGCCTAAGCCACGGCAGGCCT
GGGTGTGGGCCGCTGTGCGTGGGCCCTGCTCGGTGAGCTGTGGGGCAGGGCTGCGCTGGGTAAACTACAGCTGCCTGGACCAGGCCAGGAAGGAGTTGGT
GGAGACTGTCCAGTGCCAAGGGAGCCAGCAGCCACCAGCGTGGCCAGAGGCCTGCGTGCTCGAACCCTGCCCTCCCTACTGGGCGGTGGGAGACTTCGGC
CCATGCAGCGCCTCCTGTGGGGGCGGCCTGCGGGAGCGGCCAGTGCGCTGCGTGGAGGCCCAGGGCAGCCTCCTGAAGACATTGCCCCCAGCCCGGTGCA
GAGCAGGGGCCCAGCAGCCAGCTGTGGCGCTGGAAACCTGCAACCCCCAGCCCTGCCCTGCCAGGTGGGAGGTGTCAGAGCCCAGCTCATGCACATCAGC
TGGTGGAGCAGGCCTGGCCTTGGAGAACGAGACCTGTGTGCCAGGGGCAGATGGCCTGGAGGCTCCAGTGACTGAGGGGCCTGGCTCCGTAGATGAGAAG
CTGCCTGCCCCTGAGCCCTGTGTCGGGATGTCATGTCCTCCAGGCTGGGGCCATCTGGATGCCACCTCTGCAGGGGAGAAGGCTCCCTCCCCATGGGGCA
GCATCAGGACGGGGGCTCAAGCTGCACACGTGTGGACCCCTGCGGCAGGGTCGTGCTCCGTCTCCTGCGGGCGAGGTCTGATGGAGCTGCGTTTCCTGTG
CATGGACTCTGCCCTCAGGGTGCCTGTCCAGGAAGAGCTGTGTGGCCTGGCAAGCAAGCCTGGGAGCCGGCGGGAGGTCTGCCAGGCTGTCCCGTGCCCT
GCTCGGTGGCAGTACAAGCTGGCGGCCTGCAGCGTGAGCTGTGGGAGAGGGGTCGTGCGGAGGATCCTGTATTGTGCCCGGGCCCATGGGGAGGACGATG
GTGAGGAGATCCTGTTGGACACCCAGTGCCAGGGGCTGCCTCGCCCGGAACCCCAGGAGGCCTGCAGCCTGGAGCCCTGCCCACCTAGGTGGAAAGTCAT
GTCCCTTGGCCCATGTTCGGCCAGCTGTGGCCTTGGCACTGCTAGACGCTCGGTGGCCTGTGTGCAGCTCGACCAAGGCCAGGACGTGGAGGTGGACGAG
GCGGCCTGTGCGGCGCTGGTGCGGCCCGAGGCCAGTGTCCCCTGTCTCATTGCCGACTGCACCTACCGCTGGCATGTTGGCACCTGGATGGAGTGCTCTG
TTTCCTGTGGGGATGGCATCCAGCGCCGGCGTGACACCTGCCTCGGACCCCAGGCCCAGGCGCCTGTGCCAGCTGATTTCTGCCAGCACTTGCCCAAGCC
GGTGACTGTGCGTGGCTGCTGGGCTGGGCCCTGTGTGGGACAGGGTACGCCCAGCCTGGTGCCCCACGAAGAAGCCGCTGCTCCAGGACGGACCACAGCC
ACCCCTGCTGGTGCCTCCCTGGAGTGGTCCCAGGCCCGGGGCCTGCTCTTCTCCCCGGCTCCCCAGCCTCGGCGGCTCCTGCCCGGGCCCCAGGAAAACT
CAGTGCAGTCCA
GTGCCTGTGGCAGGCAGCACCTTGAGCCAACAGGAACCATTGACATGCGAGGCCCAGGGCAGGCAGACTGTGCAGTGGCCATTGGGCG
GCCCCTCGGGGAGGTGGTGACCCTCCGCGTCCTTGAGAGTTCTCTCAACTGCAGTGCGGGGGACATGTTGCTGCTTTGGGGCCGGCTCACCTGGAGGAAG
ATGTGCAGGAAGCTGTTGGACATGACTTTCAGCTCCAAGACCAACACGCTGGTGGTGAGGCAGCGCTGCGGGCGGCCAGGAGGTGGGGTGCTGCTGCGGT
ATGGGAGCCAGCTTGCTCCTGAAACCTTCTACAGAGAATGTGACATGCAGCTCTTTGGGCCCTGGGGTGAAATCGTGAGCCCCTCGCTGAGTCCAGCCAC
GAGTAATGCAGGGGGCTGCCGGCTCTTCATTAATGTGGCTCCGCACGCACGGATTGCCATCCATGCCCTGGCCACCAACATGGGCGCTGGGACCGAGGGA
GCCAATGCCAGCTACATCTTGATCCGGGACACCCACAGCTTGAGGACCACAGCGTTCCATGGGCAGCAGGTGCTCTACTGGGAGTCAGAGAGCAGCCAGG
CTGAGATGGAGTTCAGCGAGGGCTTCCTGAAGGCTCAGGCCAGCCTGCGGGGCCAGTACTGGACCCTCCAATCATGGGTACCGGAGATGCAGGACCCTCA
GTCCTGGAAGGGAAAGGAAGGAACCTGAGGGTCATTGAACATTTGTTCCGTGTCTGGCCAGCCCTGGAGGGTTGACCCCTGGTCTCAGTGCTTTCCAATT
CGAACTTTTTCCAATCTTAGGTATCTACTTTAGAGTCTTCTCCAATGTCCAAAAGGCTAGGGGGTTGGAGGTGGGGACTCTGGAAAAGCAGCCCCCATTT
CCTCGGGTACCAATAAATAAAACATGCAGGCTG
  • refseq_ADAMTS13.F2 (forward primer)
  • refseq_ADAMTS13.R2 (reverse primer)
  • Alternative donor

Frame 0

NHDVFGTASHLSDGSGDPGEGVSRGPGIPCEPP
SVGFWSSVPSPD*MA*ASSKGVGVHIRRAVWCAG
LGCRLP*TATILEQGPACSRRSCRPPTLATAPA
LAGSFQE*TLPNRPAQ**AGLSHSILTRFPVTK
APSHSAPLLGLALLRMHQRHPRARCPPLCVAGIL
ACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSP
GAPLKGRPPSPGFQRQRQRQRRAAGGILHLELL
VAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS
LGAQFRVHLVKMVILTEPEGAPNITANLTSSLL
SVCGWSQTINPEDDTDPGHADLVLYITRFDLEL
PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLG
VTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASD
GAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDP
PRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKA
VACTFAREHLDMCQALSCHTDPLDQSSCSRLLV
PLLDGTECGVEKWCSKGRCRSLVELTPIAAVHG
RWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG
GRACVGADLQAEMCNTQACEKTQLEFMSQQCAR
TDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH
MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTL
SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDN
STCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI
ANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPS
LLEDGRVEYRVALTEDRLPRLEEIRIWGPLQED
ADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQA
WVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELV
ETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG
PCSASCGGGLRERPVRCVEAQGSLLKTLPPARC
RAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA
GGAGLALENETCVPGADGLEAPVTEGPGSVDEK
LPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG
SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLC
MDSALRVPVQEELCGLASKPGSRREVCQAVPCP
ARWQYKLAACSVSCGRGVVRRILYCARAHGEDD
GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM
SLGPCSASCGLGTARRSVACVQLDQGQDVEVDE
AACAALVRPEASVPCLIADCTYRWHVGTWMECS
VSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP
VTVRGCWAGPCVGQGTPSLVPHEEAAAPGRTTA
TPAGASLEWSQARGLLFSPAPQPRRLLPGPQEN
SVQS
SACGRQHLEPTGTIDMRGPGQADCAVAIGR
PLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRK
MCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLR
YGSQLAPETFYRECDMQLFGPWGEIVSPSLSPAT
SNAGGCRLFINVAPHARIAIHALATNMGAGTEG
ANASYILIRDTHSLRTTAFHGQQVLYWESESSQ
AEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQ
SWKGKEGT*GSLNICSVSGQPWRVDPWSQCFPI
RTFSNLRYLL*SLLQCPKG*GVGGGDSGKAAPI
SSGTNK*NMQA

Frame 1

TTMSLAQPLICQMGAGTPERESAEVLAFLVNPR
LWVSGPVSLLQIRWLRPPLRGWACTSGELSGVQ
DWAAGYPELQPS*SKAQLAAGGAAGRPP*PRPLP
WQEASKSKHCLIVPPSSEQACPIPY*PDSQSPR
PPLTPLHSSGWLS*GCTSVTPGQDALPSVWPES
LPVAFSWAAGDPPISSRVVFRLWSHRPCLLT*AL
VLP*KAALLPLASRGRGRGRGGLQAASYTWSCW
WPWAPMSSRLTRRTQSAMCSPTSTSGQNCFGTR
PWGLSFGCTW*RWSF*QSLRVPQISQPTSPRPC*
ASVGGARPSTLRTTRILAMLTWSSISLGLTWSC
LMVTGRCGASPSWAVPAPQPGAASLPRTLASTW
ESPLPMRLGTASAWSTTARPAAAAAPADT*WLRT
APRPAPASPGPPAAAGSC*ACSAQDGRAACGTR
RGLNPGPRGTRRMRSLASTTAPTSSAAWPSAPR
LSPAPSPGSTWICARPSPATQTRWTKAAAAASSF
LSWMGQNVAWRSGAPRVAAAPWWS*PP*QQCMG
AGLAGVPEVLAPAPAEEVWSPGGGSATTPDLPL
GGVHVLVLTSRPRCATLRPARRPSWSSCRNSAPG
PTASRCAPPLAAPPSTTGVLLYHTAKGMLCADT
CAGPLARASS*SVETASSMGPGVCQVAPGRTGP
*ACVCRAAAGHLAVMVGWTPSRYGTGARCVVGTT
ARAAHGRALSQLAERENMSHF*QLPPT*PVSTL
PTTGLSSHTWR*GSEGAMSWLGR*ASPLTPPTP
PSWRMVVSSTEWPSPRTGCPAWRRSASGDPSRKM
LTSRFTGGMARSMATSPAQTSPSPTSSLSHGRP
GCGPLCVGPAR*AVGQGCAG*TTAAWTRPGRSW
WRLSSAKGASSHQRGQRPACSNPALPTGRWETSA
HAAPPVGAACGSGQCAAWRPRAAS*RHCPQPGA
EQGPSSQLWRWKPATPSPALPGGRCQSPAHAHQ
LVEQAWPWRTRPVCQGQMAWRLQ*LRGLAP*MRS
CLPLSPVSGCHVLQAGAIWMPPLQGRRLPPHGA
ASGRGLKLHTCGPLRQGRAPSPAGEV*WSCVSC
AWTLPSGCLSRKSCVAWQASLGAGGRSARLSRAL
LGGSTSWRPAA*AVGEGSCGGSCIVPGPMGRTM
VRRSCWTPSARGCLARNPRRPAAWSPAHLGGKS
CPLAHVRPAVALALLDARWPVCSSTKARTWRWTR
RPVRRWCGPRPVSPVSLPTAPTAGMLAPGWSAL
FPVGMASSAGVTPASDPRPRRLCQLISASTCPS
R*LCVAAGLGPVWDRVRPAWCPTKKPLLQDGPQP
PLLVPPWSGPRPGACSSPRLPSLGGSCPGPRKT
QCSP
VPVAGSTLSQQEPLTCEAQGRQTVQWPLG
GPSGRW*PSASLRVLSTAVRGTCCCFGAGSPGGR
CAGSCWT*LSAPRPTRWW*GSAAGGQEVGCCCG
MGASLLLKPSTENVTCSSLGPGVKS*APR*VQP
RVMQGAAGSSLMWLRTHGLPSMPWPPTWALGPRE
PMPATS*SGTPTA*GPQRSMGSRCSTGSQRAAR
LRWSSARAS*RLRPACGASTGPSNHGYRRCRTL
SPGRERKEPEGH*TFVPCLASPGGLTPGLSAFQF
ELFPILGIYFRVFSNVQKARGLEVGTLEKQPPF
PRVPINKTCRL

Frame 2

PRCLWHSLSSVRWERGPRRGSQPRSWHSL*TPV
CGFLVQCPFSRLDGLGLL*GGGRAHPESCLVCR
TGLQVTLNCNHLRARPSLQQEELQAAHPSHGPC
PGRKLPRVNTA*SSRPVVSRPVPFHTDQIPSHQG
PLSLRSTPRAGSPEDAPASPPGKMPSPLCGRNP
CLWLSPGLLGTLPFPAELSSGFGATGRVFLLEP
WCSLKRPPSFPWLPEAEAEAEAGCRRHPTPGAAG
GRGPRCLPGSPGGHRALCAHQPQHRGRTASGPV
PGGSVSGAPGEDGHSDRA*GCPKYHSQPHLVPA
ERLWVEPDHQP*GRHGSWPC*PGPLYH*V*PGVA
*W*PAGAGRHPAGRCLLPNLELPHYRGHWLRPG
SHHCP*DWAQLRPGARRRARQRLRPQRTRDGFG
RRRAPRRPRLVPLQPPAAAEPAQRRTGALRVGPA
AASTRVRGAPAGCAAWPLLQRQRAVPRGLRPQG
CRLHLRQGAPGYVPGPLLPHRPAGPKQLQPPPR
SSPGWDRMWRGEVVLQGSLPLPGGADPHSSSAWA
LV*LGSPKSLLPLLRRRCGHQEAAVQQPQTCLW
GACMCWC*PPGRDVQHSGLREDPAGVHVATVRQ
DRRPAAALLPWRRLLLPLGCCCTTQPRGCSVQTH
VPGHWRELHHEAWRQLPRWDPVYAKWPPGGRDP
EPVCVGQLQDIWL*W*DGLPAGMGQVPGVWWGQ
QHVQPTEGLFHSWQSERICHISDSYPQPDQCLHC
QPQASLHTLGGEDRRALCRGWEDEHLP*HHLPL
PPGGWSCRVQSGPHRGPAAPPGGDPHLGTPPGR
C*HPGLQAVWRGVWQPHPPRHHLHLLPA*ATAGL
GVGRCAWALLGELWGRAALGKLQLPGPGQEGVG
GDCPVPREPAATSVARGLRARTLPSLLGGGRLR
PMQRLLWGRPAGAASALRGGPGQPPEDIAPSPVQ
SRGPAASCGAGNLQPPALPCQVGGVRAQLMHIS
WWSRPGLGERDLCARGRWPGGSSD*GAWLRR*E
AACP*ALCRDVMSSRLGPSGCHLCRGEGSLPMGQ
HQDGGSSCTRVDPCGRVVLRLLRARSDGAAFPV
HGLCPQGACPGRAVWPGKQAWEPAGGLPGCPVP
CSVAVQAGGLQRELWERGRAEDPVLCPGPWGGRW
*GDPVGHPVPGAASPGTPGGLQPGALPT*VESH
VPWPMFGQLWPWHC*TLGGLCAARPRPGRGGGR
GGLCGAGAARGQCPLSHCRLHLPLACWHLDGVLC
FLWGWHPAPA*HLPRTPGPGACAS*FLPALAQA
GDCAWLLGWALCGTGYAQPGAPRRSRCSRTDHS
HPCWCLPGVVPGPGPALLPGSPASAAPARAPGKL
SAVQ
CLWQAAP*ANRNH*HARPRAGRLCSGHWA
APRGGGDPPRP*EFSQLQCGGHVAALGPAHLEE
DVQEAVGHDFQLQDQHAGGEAALRAARRWGAAAV
WEPACS*NLLQRM*HAALWALG*NREPLAESSH
E*CRGLPALH*CGSARTDCHPCPGHQHGRWDRG
SQCQLHLDPGHPQLEDHSVPWAAGALLGVREQPG
*DGVQRGLPEGSGQPAGPVLDPPIMGTGDAGPS
VLEGKGRNLRVIEHLFRVWPALEG*PLVSVLSN
SNFFQS*VSTLESSPMSKRLGGWRWGLWKSSPHF
LGYQ*IKHAG

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