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Sequences

Sequence NM_021723

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGACAGTTACCCCAGGGAGATTA TGTAAAAAAGCCTGGAGATGGTGACTCTTTTTATAGCGACATTCCTCCCGGAGTCAGCACAAACTCAGCATCTAGTTCTAAGAAGAGGTCAAATGGGCTC TCTCATTCTTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAG GCAACAAAAAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTAT TGCCTCCAGCAGAAAATACCCTTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAA GATCAACTGTTTACATGTGATACATCGAAAACTGTTTACTTCAACTTTTATAGAAACCCAGGCTCATGGAATCACTGCAAATCTATCTGCTCTTCAGACA ATACGAAGACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCATTTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATG AAAAGAACTACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGGATAATCCGCATGACAGATAATATGTAGAAATATTCATA AAGTTAACTCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACTTGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATG CTATATGCATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAGAAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCT GCAGGACTTTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTATTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGC ATACAAGGACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA

refseq_ADAM22.F2 (forward primer)
refseq_ADAM22.R2 (reverse primer)
Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH *TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL *EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC* A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH NCWHHFSAGPHIRNNCVGL*KLSRTETVTPGRL CKKAWRW*LFL*RHSSRSQHKLSI*F*EEVKWA LSFLE*KDSRHKTYFRHL*KWATSK*LLAR*PGR QQKENQRQKI*TSV*FN*DFISCQVSFFINWVY CLQQKIPLPNASTS**GQESEPTKCQAMGDIHL RSTVYM*YIENCLLQLL*KPRLMESLQIYLLFRQ YEDPLRCYRGEEAEFHIWLPFSFCHWLRI*LTM KRTTEILHYNMEQ*RYWYVNG*SA*QIICRNIH KVNSHDPNVASFLRYNSGFRT*RSEAHPHCKQ*C YMHEASVYCFPYLRKQHPIIEMSMQG*GI*DFS AGL*SFERPISHRLTLNMYFYFCFVFYFSYLY* HTRTIVYM*HF*NFKK

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD LIYKDQLKTRIVLVAMETWATDNKFAISENPLI TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK LLDPPECGNGFIETGEECDCGTPAECVLEGAECC KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG IIAGTILVLALILGITAWGYKNYREQRQLPQGDY VKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGL SHSWSERIPDTKHISDICENGRPRSNSWQGNLG GNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSI ASSRKYPYPMPPLPDEDKKVNRQSARLWETSI* DQLFTCDTSKTVYFNFYRNPGSWNHCKSICSSD NTKTL*DATEERKRSFTSGYHFLFVIGLGFN*P* KELLKYYTITWNNKGTGMLMDNPHDR*YVEIFI KLTHMTQM*QVS*GTIVDSELDVLRHILTVNSN AICMKLLFIVFHI*GNNIP**K*ACRAKAYRIFL QDFKALKGQYPIG*L*TCIFIFVLFFTFHIYIS IQGQLYICNIFKILKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR KTASWSARASCHCASSTARAAKTKVGTTRSTRG CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK* TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH *PIILVLSQTKES*QVVNVNARTRGPGA*WETLA IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ* MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN* ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG* VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A *LLAPF*CWPSY*E*LRGVIKTIENRDSYPREI M*KSLEMVTLFIATFLPESAQTQHLVLRRGQMGS LILGVKGFQTQNIFQTSVKMGDLEVTLGKVTWE ATKRKSEAKDLDLGLIQLRLYLLPSLLLHQLGL LPPAENTLTQCLHFLMRTRK*TDKVPGYGRHPFK INCLHVIHRKLFTSTFIETQAHGITANLSALQT IRRPSEMLQRRGSGVSHLVTIFFLSLA*DLTNH EKNY*NITL*HGTIKVLVC*WIIRMTDNM*KYS* S*LT*PKCSKFPKVQ*WIQNLTF*GTSSL*TVM LYA*SFCLLFSIFKETTSHNRNEHAGLRHIGFF CRTLKL*KANIP*ANFKHVFLFLFCFLLFIFILA YKDNCIYVTFLKF*K

Sequence NM_016351

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGGTCAAATGGGCTCTCTCATTC TTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAGGCAACAAA AAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTATTGCCTCCA GCAGAAAATACCCTTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAAGATCAACT GTTTACATGTGATACATCGAAAACTGTTTACTTCAACTTTTATAGAAACCCAGGCTCATGGAATCACTGCAAATCTATCTGCTCTTCAGACAATACGAAG ACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCATTTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATGAAAAGAAC TACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGGATAATCCGCATGACAGATAATATGTAGAAATATTCATAAAGTTAAC TCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACTTGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATGCTATATGC ATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAGAAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCTGCAGGACT TTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTATTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGCATACAAGG ACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA

refseq_ADAM22.F2 (forward primer)
refseq_ADAM22.R2 (reverse primer)
Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH *TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL *EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC* A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH NCWHHFSAGPHIRNNCVGL*KLSRTEVKWALSF LE*KDSRHKTYFRHL*KWATSK*LLAR*PGRQQ KENQRQKI*TSV*FN*DFISCQVSFFINWVYCLQ QKIPLPNASTS**GQESEPTKCQAMGDIHLRST VYM*YIENCLLQLL*KPRLMESLQIYLLFRQYE DPLRCYRGEEAEFHIWLPFSFCHWLRI*LTMKRT TEILHYNMEQ*RYWYVNG*SA*QIICRNIHKVN SHDPNVASFLRYNSGFRT*RSEAHPHCKQ*CYM HEASVYCFPYLRKQHPIIEMSMQG*GI*DFSAGL *SFERPISHRLTLNMYFYFCFVFYFSYLY*HTR TIVYM*HF*NFKK

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD LIYKDQLKTRIVLVAMETWATDNKFAISENPLI TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK LLDPPECGNGFIETGEECDCGTPAECVLEGAECC KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG IIAGTILVLALILGITAWGYKNYREQRSNGLSHS WSERIPDTKHISDICENGRPRSNSWQGNLGGNK KKIRGKRFRPRSNSTETLSPAKSPSSSTGSIAS SRKYPYPMPPLPDEDKKVNRQSARLWETSI*DQL FTCDTSKTVYFNFYRNPGSWNHCKSICSSDNTK TL*DATEERKRSFTSGYHFLFVIGLGFN*P*KE LLKYYTITWNNKGTGMLMDNPHDR*YVEIFIKLT HMTQM*QVS*GTIVDSELDVLRHILTVNSNAIC MKLLFIVFHI*GNNIP**K*ACRAKAYRIFLQD FKALKGQYPIG*L*TCIFIFVLFFTFHIYISIQG QLYICNIFKILKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR KTASWSARASCHCASSTARAAKTKVGTTRSTRG CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK* TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH *PIILVLSQTKES*QVVNVNARTRGPGA*WETLA IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ* MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN* ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG* VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A *LLAPF*CWPSY*E*LRGVIKTIENRGQMGSLI LGVKGFQTQNIFQTSVKMGDLEVTLGKVTWEATK RKSEAKDLDLGLIQLRLYLLPSLLLHQLGLLPP AENTLTQCLHFLMRTRK*TDKVPGYGRHPFKIN CLHVIHRKLFTSTFIETQAHGITANLSALQTIRR PSEMLQRRGSGVSHLVTIFFLSLA*DLTNHEKN Y*NITL*HGTIKVLVC*WIIRMTDNM*KYS*S* LT*PKCSKFPKVQ*WIQNLTF*GTSSL*TVMLYA *SFCLLFSIFKETTSHNRNEHAGLRHIGFFCRT LKL*KANIP*ANFKHVFLFLFCFLLFIFILAYK DNCIYVTFLKF*K

Sequence NM_021722

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGGTCAAATGGGCTCTCTCATTC TTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAGGCAACAAA AAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGTATTTAAACCCATGGTTCAAAAGAGACTATAATGTAGCTAAGTGGGTAGAAG ATGTGAATAAAAACACTGAAGGACCATACTTTAGGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTATTGCCTCCAGCAGAAAATACCC TTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAAGATCAACTGTTTACATGTGAT ACATCGAAAACTGTTTACTTCAACTTTTACTTCAGACAATACGAAGACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCAT TTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATGAAAAGAACTACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGG ATAATCCGCATGACAGATAATATGTAGAAATATTCATAAAGTTAACTCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACT TGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATGCTATATGCATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAG AAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCTGCAGGACTTTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTA TTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGCATACAAGGACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA

refseq_ADAM22.F2 (forward primer)
refseq_ADAM22.R2 (reverse primer)
Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH *TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL *EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC* A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH NCWHHFSAGPHIRNNCVGL*KLSRTEVKWALSF LE*KDSRHKTYFRHL*KWATSK*LLAR*PGRQQ KENQRQKI*TSV*FN*VFKPMVQKRL*CS*VGRR CE*KH*RTIL*DFISCQVSFFINWVYCLQQKIP LPNASTS**GQESEPTKCQAMGDIHLRSTVYM* YIENCLLQLLLQTIRRPSEMLQRRGSGVSHLVTI FFLSLA*DLTNHEKNY*NITL*HGTIKVLVC*W IIRMTDNM*KYS*S*LT*PKCSKFPKVQ*WIQN LTF*GTSSL*TVMLYA*SFCLLFSIFKETTSHNR NEHAGLRHIGFFCRTLKL*KANIP*ANFKHVFL FLFCFLLFIFILAYKDNCIYVTFLKF*K

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD LIYKDQLKTRIVLVAMETWATDNKFAISENPLI TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK LLDPPECGNGFIETGEECDCGTPAECVLEGAECC KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG IIAGTILVLALILGITAWGYKNYREQRSNGLSHS WSERIPDTKHISDICENGRPRSNSWQGNLGGNK KKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYP YPMPPLPDEDKKVNRQSARLWETSI*DQLFTCD TSKTVYFNFYFRQYEDPLRCYRGEEAEFHIWLP FSFCHWLRI*LTMKRTTEILHYNMEQ*RYWYVNG *SA*QIICRNIHKVNSHDPNVASFLRYNSGFRT *RSEAHPHCKQ*CYMHEASVYCFPYLRKQHPII EMSMQG*GI*DFSAGL*SFERPISHRLTLNMYFY FCFVFYFSYLY*HTRTIVYM*HF*NFKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR KTASWSARASCHCASSTARAAKTKVGTTRSTRG CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK* TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH *PIILVLSQTKES*QVVNVNARTRGPGA*WETLA IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ* MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN* ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG* VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A *LLAPF*CWPSY*E*LRGVIKTIENRGQMGSLI LGVKGFQTQNIFQTSVKMGDLEVTLGKVTWEATK RKSEAKDLDLGLIQLSI*THGSKETIM*LSG*K M*IKTLKDHTLGLYLLPSLLLHQLGLLPPAENT LTQCLHFLMRTRK*TDKVPGYGRHPFKINCLHVI HRKLFTSTFTSDNTKTL*DATEERKRSFTSGYH FLFVIGLGFN*P*KELLKYYTITWNNKGTGMLM DNPHDR*YVEIFIKLTHMTQM*QVS*GTIVDSEL DVLRHILTVNSNAICMKLLFIVFHI*GNNIP** K*ACRAKAYRIFLQDFKALKGQYPIG*L*TCIF IFVLFFTFHIYISIQGQLYICNIFKILKK