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Sequences

Sequence NM_133370

GTAAACAGCGCAGGGCATTTCGGGAGCGGGATTGTTTCGCGCAGGAAGCAGGCTCCATTTTAGCGCCGCCCGCCGTCGCCATCTGTTTCCCTTCCCTCCC CCATACCTAGCCCGAGTCTGAGCCCTAACGAGAAGGCTGGGCCTAGGCCGCTGGATGCTGGAGTGAAAGGAAGGGAGAAAGGGAAAAAGCGGGAAGAGTC GAGAAGGCTGAGTGTTAAGAGGCCAAGTGCGACGCGCGTATCCGGGCAGACGGACTGACGGACGGGCCCGTGCTTCTGCCGCGGCTGCGGCGCCCGCGCG AGTCGCGTCTAAGCGGCGGCGGCGGTGGCAGCGGCGGAAACCGAAGGGGAGCCATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCT GGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTGTATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGT GATCGAATGGAATCTACTGATACCAAACGACAAAAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAA GAATAGTTAGTACAAAAGGAAAGTCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCG TCTATCAAGTAGTGCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCA GATGGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGCTCTGACC ATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAGGAAGATGAAGAAGTAGA AGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAGGAGGAAGAAGAAGAA TATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCCAGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATG GGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGATGAGAAAAAGAAGGAAAGGAAGAGAGCTAGAGGCATATCTCCAATTGTTTTTGATAGAAGTGG AAGCTCTGCATCAGAGTCATATGCAGATCAAACCAGTAAACTCAAATATGTGCTTCAAGATGCAAGATTTTTCCTCATAAAGAGTAACAACCATGAGAAT GTGTCTCTTGCCAAAGCGAAGGGTGTATGGTCCACGCTCCCTGTAAATGAGAAGAAATTAAATCTTGCATTTAGATCTGCAAGGAGTGTTATCTTAATAT TTTCTGTCAGAGAGAGTGGAAAATTTCAAGGGTTTGCAAGACTTTCTTCAGAATCACATCACGGAGGATCTCCTATACACTGGGTGCTTCCAGCAGGAAT GAGTGCTAAAATGCTGGGAGGTGTCTTTAAAATTGACTGGATTTGCAGGCGTGAATTACCCTTCACTAAGTCGGCTCATCTCACCAATCCTTGGAATGAA CATAAACCAGTAAAGATCGGACGTGATGGACAGGAAATTGAACTTGAATGTGGAACCCAGCTTTGTCTTCTGTTTCCCCCCGATGAAAGTATTGACTTGT ATCAGGTCATTCATAAAATGCGTCACAAGAGAAGAATGCATTCTCAGCCCCGATCACGAGGACGTCCATCCCGTCGAGAACCAGTCCGGGATGTGGGAAG GCGTCGACCAGAAGATTATGATATTCATAACAGCAGAAAGAAACCAAGGATTGACTATCCCCCTGAGTTTCACCAGAGACCAGGGTATTTAAAGGATCCA CGATACCAGGAAGTGGACAGACGATTTTCAGGAGTTCGCCGAGATGTGTTTTTAAATGGGTCCTACAATGATTATGTGAGGGAATTTCATAACATGGGAC CACCACCACCTTGGCAAGGAATGCCCCCTTACCCAGGAATGGAACAACCTCCACACCATCCTTACTATCAGCACCATGCTCCACCTCCTCAAGCTCATCC CCCTTACTCAGGACATCATCCAGTACCACATGAAGCAAGATACAGAGATAAACGAGTACATGATTATGATATGAGGGTGGATGATTTCCTTCGTCGCACA CAAGCTGTTGTCAGTGGCCGGAGAAGTAGACCCCGTGAAAGAGACCGGGAACGAGAGCGAGACCGCCCTAGAGATAACAGACGAGACAGAGAGCGAGATA GAGGACGTGATAGAGAAAGAGAAAGAGAGCGATTATGTGATCGAGACAGAGACCGAGGGGAGAGAGGTCGATATAGAAGATAATGGGCTTTTGGAAGCAC TGATTGTTTAAAGATACAAAAAATCTTGTATTTTTTTTTTGTGTGTGTTTACAAGTAGTAAATTTATTTTCAGCTGTCTGCCTATGAAGTTCATTGTGTA GAAGGATTTATTATGACCCCCTTTGTTCCAAGCATGCAGTATCATAAGAACTGGAAAAACTCAAATCCGCCAAAAATCCACAGCTGACAGTTGAATTGAC ACTTTTATTGGGGCAGAATGGAACAGTCCAAGAATGTAGATACTGATTCTTTCTCCATAAATGTTCTTATAGTGTGTTCATCCTAGAGTTATTTTTTTGT TTGTTTTTTTCCTTTTTGGATCTTGATTGATAACTGCCATGATATTTTGCTTTGATGTGTTTCTACATGTAGTTGCACACGGTTCAGTAAAAATAATGCT GCTATCGAGTATGCAAATATTGAAGTATGATGGTTTGACTGTATGGCAGTGTTGTAGCAGCCTCTTGTTTTTTTCCCCATTGCCTCTTTTTTTAAAAAAC TTATAAAGTCACTTTTTATTTTTCCTCAGTCTTCAATGACGAGAGCAATATTAAGAAGACATTGCTATCTAATTTTTAATCTTTTTAAATGAAAAATTCC TATGTTCAGTAGCGTGGTTGATGCTATTGTTTAGCCTTCCCCTCCAAATTGTATACATTGGCTTGGAATGTTCACAACTTGCGTGCGTGGCAGCGGAAGA CGATTCCCATATTCTACATTGCTACTGTTTTGTATAAAATAAATTGGTAAAGATTGACGGTTATCTTTTGTATCTTTTTCTTATCCAATTGCAGGTTTGT TTTATTATGCAATAATGGACATAAAAGCATGCTTTTTGTTCAGGAATTTTAGGAACCCCATTTGCTTTTTTTGAGGCACACTTTAGCAGAAATGATTGAC CTAGGCCTGTTGCATTAAAAGCTTACTTCTATTTCTAACATAAGATACACAGAGTTATGTTAATAATTTGGTTAAGTATTTATACACCTGATAACATTTT GAGTCTACTCTGATCACAGAATCGTTTATTTAGGTTTTCTATTTGTTGTTTTAGTCTTCTGTAAGTGAACGACTTTGTACATGCTTTCTACTTTACTTCA TAAATGGACTTTTAACCCTCTTGTATTAGTTCTGTATTTTAAGTTAACTGTCCAGTTCTCCCAGTGGTAACCAACTATAACATAGAAATAGAGCCGCTCA AGAAAACAGTTTATGAAATAATTTTTTTGAATTTTTTCTTGAGTTACACCTGGAGTTTTGGCCTTTGGAATTTGGCCTTTATAAACATTAGGAATATTTG AATGTTTGATTTTTTTATAGTATCAACAGTTGTACTGTGTACCAGATCACATAGTACAGTTTTACATTTAATCTATATTGGCCTGAAAAGAACAACACAG GCACTTTACTCTTAAAGGATATAATAAACTATAGTTATACTGCATTCATATTCATACCAGCATGTAGTATCTTTCCCTGCATTCACAGAAGTTTTATTTA CAATGACAAAACTAAAGCCTGAGGATTTGTTTTAAATCTGCATTGTGGTAGAGAGGAAAAAGTACTTTTAAGGAAACCTGGGTTCTAGTTTTGTCATTGT CTTTAATTAAACCGGTTAGTGATACATGGTAAGTCACTTCATTGGCATTTTGTGTATTCATCAGTAAGCTAGACAAGATGATAGCTACAGTTTAAGAATT TCTGTAACCATTATACAAAACTGGTAGGTAATATTAAAGGTATTTTCCTGAAATAATAGGAATAAATACTGAGCACTTTGTATGCAATAGAGACTTTGTG CTTTTATATACAGACTCATTTAAATGGGCTCAGAGAGGCTAGTAAACTTGCCCAAGATTAGAAAGGTAGTAATTGATGGGCCAAGATTTTACCCATGTTT TTATTTGGTGTTTCTAAACCACCTCATCACTTTTGAAAAAACAGTATATAAATTAATAAATGTTTTGGAGATGGAGTCTGTCGCCCAGGTGGAGGGCAGT GGCATGATCTTGGCTCACTGCAACCTCCTGCCTCAGCCTCCCGAATGGCTGGGACTACAGGCACCCACCACCACACCCCGCTAATTTTTGTAATTTTAGT AGAGATGGGGTTCCAACATGTTGGCCAGGCTGGTCTCAAACTCGACCTCAAGTGACCTCACCTGCCTCAGCCTCCTAAAGTGTTGGGATTACAGGCGTGA GCCACTGCACCTGGCCTGAGATTTTTAAACATTAACATTTCCTTCAGGCTTAAGCAGAGGATTTTTCTAAAGTGCCATCCAATTAGATGTTAAGTTATGC TTTGTATGTTGAGCTTAGTATTGAGTCGATCTATTTTAAAAAGCCAACATTAAGTTTTTACCAAGTATCTGGCACTATTCTAAACAATTCTGTTGGCTCA CATAATCATCACTGTTTTCTCCTTTCCTAATTTTTAAAATAAACTTACCGGAACATTGTATAAAAAATGCAAGATTTTTTTCTGTACAGAAGAGTCAGTA TATAAAAATCAGTATGTTTTATTTAATATTCGTACACATGACAGCTTTTGTCACTGTGAGAAGACATGGTTTCTTTCGTGTACTCCACTGTGCTGTGATT CTAACAATCTACATTAGTATGATGTGTTCAGATGAAAAACAGAAAATTCAGTCATTCCGAGTTTAGAAATCCGGTCAGGGATTTTATTGGCTGGAGTAAT AGTTCAAAGGAGTGAAAATTCAAGCATGTAATTTTTGGATTTGATTTCCTCCATAATGATTTCCTCCATAATGGCTTTTTTTCAAGCATGGTCTAATTTT TCAGAAAATGGCCATTATCTCCAAGCTTCCATTGTCCATGTAGTTTCAGTGGCAGGAGAGAGACTATTTTCCTCCCAGTGTCCATGTCAGTTCCCCAAAA GGACTGAATAGCCATGTTGGTTTTGGAGCCAGCCGTAATCCAATCTGTATTTCCAAGGAAATGGGGTTCTTTGTCTCCCAGCATTGGGAAGCAAGAGAGG CACATGTTATGGTCACCTCTGTGAGGATTACATCAGGAAGGACAGTCTCCAAAAGACATGGACAGAGGAAATTTAGCAGATGTCCATTAAATCAGGATCT CATACAAGTTATAACACCTGAATGTTTGACTTTTCAGAGTATTTTGCCATCACAGGTGTGGCATCTTGCCCTTGGATATATCTACATTCTGCTGTAGAAT GTCGTGGTCTTTCTGAGGGTCACATACATCCTGTCTTGTCATAATGTTAACCATTAAGAGTCCTCAGGGGCATGGAATTGAAGAAGGAACTGTTGCCAGC AGTTAACTGACCAAGCTAGAGTTCCCTGACCCAACGTAAGGGTGACTGTGACACACATGGATAATTTTAGCTTCATGTTTAAGATTTTGTTATTTGGGTA GGAAACATTCCAAATGCAGTTTGAAACACATATTAAAATTGAGGCACACAGGAAAGAACTGGCTCAAGTTTAGTCCCCAAGTTCCTTATAGTAGGAATAG GAATCCTTAGAGTATAAGCAATCCATGCATAGTATTCTGTTATCTATCATGTAGATCATTTAATCTCTAATTTTTTGGGGTGGGGATTCTCTTGTTTCTA AATCTTACACTTTCAGTTTCTTCTGTGTCTTAAATATAGATTATTGACTATTGTCTTAAATACTAATAAATACATTAAATGTATCTTAAATACTA

refseq_YTHDC1.F1 (forward primer)
refseq_YTHDC1.R1 (reverse primer)
Single exon skipping

Frame 0

VNSAGHFGSGIVSRRKQAPF*RRPPSPSVSLPS PIPSPSLSPNEKAGPRPLDAGVKGREKGKKREES RRLSVKRPSATRVSGQTD*RTGPCFCRGCGARA SRV*AAAAVAAAETEGEPWRLTVGRRKMENLMF WMIF*LKYQNKMMNCIIQRVNKIKMRKRDQKEKV IEWNLLIPNDKSLLSILDNWFLSH*AHLLAITK E*LVQKESQPQSIKMRNIKDLKETSV*MLIGKF VYQVVPPENLIRINLKKPVSGKGILKGGPNLLRQ MVLRELGLKWIDVQADPASLLRKK*TLKNMALT MRLAAVVLLMSKGTTLRMRRKEWKKMWRKMKK* KKMQKKMKRWMKMERRRRKRRRRKRRRRRRKKKN MNRMRETRKRREMIMTLEVRPVTLVLNLFPSQM GLSDLVQAQMDQMRKRRKGRELEAYLQLFLIEV EALHQSHMQIKPVNSNMCFKMQDFSS*RVTTMRM CLLPKRRVYGPRSL*MRRN*ILHLDLQGVLS*Y FLSERVENFKGLQDFLQNHITEDLLYTGCFQQE *VLKCWEVSLKLTGFAGVNYPSLSRLISPILGMN INQ*RSDVMDRKLNLNVEPSFVFCFPPMKVLTC IRSFIKCVTREECILSPDHEDVHPVENQSGMWE GVDQKIMIFITAERNQGLTIPLSFTRDQGI*RIH DTRKWTDDFQEFAEMCF*MGPTMIM*GNFITWD HHHLGKECPLTQEWNNLHTILTISTMLHLLKLI PLTQDIIQYHMKQDTEINEYMIMI*GWMISFVAH KLLSVAGEVDPVKETGNESETALEITDETESEI EDVIEKEKESDYVIETETEGREVDIEDNGLLEA LIV*RYKKSCIFFLCVFTSSKFIFSCLPMKFIV* KDLL*PPLFQACSIIRTGKTQIRQKSTADS*ID TFIGAEWNSPRM*ILILSP*MFL*CVHPRVIFL FVFFLFGS*LITAMIFCFDVFLHVVAHGSVKIML LSSMQILKYDGLTVWQCCSSLLFFSPLPLFLKN L*SHFLFFLSLQ*REQY*EDIAI*FLIFLNEKF LCSVAWLMLLFSLPLQIVYIGLECSQLACVAAED DSHILHCYCFV*NKLVKIDGYLLYLFLIQLQVC FIMQ*WT*KHAFCSGILGTPFAFFEAHFSRND* PRPVALKAYFYF*HKIHRVMLIIWLSIYTPDNIL SLL*SQNRLFRFSICCFSLL*VNDFVHAFYFTS *MDF*PSCISSVF*VNCPVLPVVTNYNIEIEPL KKTVYEIIFLNFFLSYTWSFGLWNLAFINIRNI* MFDFFIVSTVVLCTRSHSTVLHLIYIGLKRTTQ ALYS*RI**TIVILHSYSYQHVVSFPAFTEVLF TMTKLKPEDLF*ICIVVERKKYF*GNLGSSFVIV FN*TG**YMVSHFIGILCIHQ*ARQDDSYSLRI SVTIIQNW*VILKVFS*NNRNKY*ALCMQ*RLC AFIYRLI*MGSERLVNLPKIRKVVIDGPRFYPCF YLVFLNHLITFEKTVYKLINVLEMESVAQVEGS GMILAHCNLLPQPPEWLGLQAPTTTPR*FL*F* *RWGSNMLARLVSNSTSSDLTCLSLLKCWDYRRE PLHLA*DF*TLTFPSGLSRGFF*SAIQLDVKLC FVC*A*Y*VDLF*KANIKFLPSIWHYSKQFCWL T*SSLFSPFLIFKINLPEHCIKNARFFSVQKSQY IKISMFYLIFVHMTAFVTVRRHGFFRVLHCAVI LTIYISMMCSDEKQKIQSFRV*KSGQGFYWLE* *FKGVKIQACNFWI*FPP**FPP*WLFFKHGLIF QKMAIISKLPLSM*FQWQERDYFPPSVHVSSPK GLNSHVGFGASRNPICISKEMGFFVSQHWEARE AHVMVTSVRITSGRTVSKRHGQRKFSRCPLNQDL IQVITPECLTFQSILPSQVWHLALGYIYILL*N VVVFLRVTYILSCHNVNH*ESSGAWN*RRNCCQ QLTDQARVP*PNVRVTVTHMDNFSFMFKILLFG* ETFQMQFETHIKIEAHRKELAQV*SPSSL**E* ESLEYKQSMHSILLSIM*II*SLIFWGGDSLVS KSYTFSFFCVLNIDY*LLS*ILINTLNVS*IL

Frame 1

*TAQGISGAGLFRAGSRLHFSAARRRHLFPFPP PYLARV*ALTRRLGLGRWMLE*KEGRKGKSGKS REG*VLRGQVRRAYPGRRTDGRARASAAAAAPAR VASKRRRRWQRRKPKGSHGG*QSGGERWRT*CS G*YFN*STRTR**TV*SRE*TR*K*EKGIKKKK *SNGIY*YQTTKAFCPF*TTGF*ATELIC*Q*QK NS*YKRKVSHRV*K*GISKI*KKQASRC*SENS SIK*CLQRTL*EST*KNLCPEKGS*KEGQISYA RWF*ENWA*SG*TCKQIQPVF*GRSEL*RIWL*P *DWQQWFF**AREQH*E*GGRSGRRCGGR*RSR RRCRRR*RGG*RWRGGGGRGGGGRGGGGGGRRR I*TG*ERPERGGK*L*HSK*GQ*LWF*ICFLHRW VCQIWFRHRWIR*EKEGKEES*RHISNCF**KW KLCIRVICRSNQ*TQICASRCKIFPHKE*QP*E CVSCQSEGCMVHAPCK*EEIKSCI*ICKECYLNI FCQREWKISRVCKTFFRITSRRISYTLGASSRN EC*NAGRCL*N*LDLQA*ITLH*VGSSHQSLE* T*TSKDRT*WTGN*T*MWNPALSSVSPR*KY*LV SGHS*NASQEKNAFSAPITRTSIPSRTSPGCGK ASTRRL*YS*QQKETKD*LSP*VSPETRVFKGS TIPGSGQTIFRSSPRCVFKWVLQ*LCEGIS*HGT TTTLARNAPLPRNGTTSTPSLLSAPCSTSSSSS PLLRTSSSTT*SKIQR*TST*L*YEGG*FPSSH TSCCQWPEK*TP*KRPGTRARPP*R*QTRQRAR* RT**RKRKRAIM*SRQRPRGERSI*KIMGFWKH *LFKDTKNLVFFFCVCLQVVNLFSAVCL*SSLC RRIYYDPLCSKHAVS*ELEKLKSAKNPQLTVELT LLLGQNGTVQECRY*FFLHKCSYSVFILELFFC LFFSFLDLD**LP*YFALMCFYM*LHTVQ*K*C CYRVCKY*SMMV*LYGSVVAASCFFPHCLFF*KT YKVTFYFSSVFNDESNIKKTLLSNF*SF*MKNS YVQ*RG*CYCLAFPSKLYTLAWNVHNLRAWQRK TIPIFYIATVLYKINW*RLTVIFCIFFLSNCRFV LLCNNGHKSMLFVQEF*EPHLLFLRHTLAEMID LGLLH*KLTSISNIRYTELC**FG*VFIHLITF *VYSDHRIVYLGFLFVVLVFCK*TTLYMLSTLLH KWTFNPLVLVLYFKLTVQFSQW*PTIT*K*SRS RKQFMK*FF*IFS*VTPGVLAFGIWPL*TLGIF ECLIFL*YQQLYCVPDHIVQFYI*SILA*KEQHR HFTLKGYNKL*LYCIHIHTSM*YLSLHSQKFYL Q*QN*SLRICFKSALW*RGKSTFKETWVLVLSL SLIKPVSDTW*VTSLAFCVFISKLDKMIATV*EF L*PLYKTGR*Y*RYFPEIIGINTEHFVCNRDFV LLYTDSFKWAQRG**TCPRLER**LMGQDFTHV FIWCF*TTSSLLKKQYIN**MFWRWSLSPRWRAV A*SWLTATSCLSLPNGWDYRHPPPHPANFCNFS RDGVPTCWPGWSQTRPQVTSPASAS*SVGITGV SHCTWPEIFKH*HFLQA*AEDFSKVPSN*MLSYA LYVELSIESIYFKKPTLSFYQVSGTILNNSVGS HNHHCFLLS*FLK*TYRNIV*KMQDFFLYRRVS I*KSVCFI*YSYT*QLLSL*EDMVSFVYSTVL*F *QSTLV*CVQMKNRKFSHSEFRNPVRDFIGWSN SSKE*KFKHVIFGFDFLHNDFLHNGFFSSMV*F FRKWPLSPSFHCPCSFSGRRETIFLPVSMSVPQK D*IAMLVLEPAVIQSVFPRKWGSLSPSIGKQER HMLWSPL*GLHQEGQSPKDMDRGNLADVH*IRI SYKL*HLNV*LFRVFCHHRCGILPLDISTFCCRM SWSF*GSHTSCLVIMLTIKSPQGHGIEEGTVAS S*LTKLEFPDPT*G*L*HTWIILASCLRFCYLG RKHSKCSLKHILKLRHTGKNWLKFSPQVPYSRNR NP*SISNPCIVFCYLSCRSFNL*FFGVGILLFL NLTLSVSSVS*I*IIDYCLKY**IH*MYLKY

Frame 2

KQRRAFRERDCFAQEAGSILAPPAVAICFPSLP HT*PESEP*REGWA*AAGCWSERKGEREKAGRV EKAEC*EAKCDARIRADGLTDGPVLLPRLRRPR ESRLSGGGGGSGGNRRGAMAADSREEKDGELNVL DDILTEVPEQDDELYNPESEQDKNEKKGSKRKS DRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNK RIVSTKGKSATEYKNEEYQRSERNKRLDADRKIR LSSSASREPYKNQPEKTCVRKRDPERRAKSPTP DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSD HETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVE EDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE YEQDERDQKEEGNDYDTRSEASDSGSESVSFTD GSVRSGSGTDGSDEKKKERKRARGISPIVFDRSG SSASESYADQTSKLKYVLQDARFFLIKSNNHEN VSLAKAKGVWSTLPVNEKKLNLAFRSARSVILI FSVRESGKFQGFARLSSESHHGGSPIHWVLPAGM SAKMLGGVFKIDWICRRELPFTKSAHLTNPWNE HKPVKIGRDGQEIELECGTQLCLLFPPDESIDL YQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGR RRPEDYDIHNSRKKPRIDYPPEFHQRPGYLKDP RYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMG PPPPWQGMPPYPGMEQPPHHPYYQHHAPPPQAHP PYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRT QAVVSGRRSRPRERDRERERDRPRDNRRDRERD RGRDRERERERLCDRDRDRGERGRYRR*WAFGST DCLKIQKILYFFFVCVYK**IYFQLSAYEVHCV EGFIMTPFVPSMQYHKNWKNSNPPKIHS*QLN* HFYWGRMEQSKNVDTDSFSINVLIVCSS*SYFFV CFFPFWILIDNCHDILL*CVSTCSCTRFSKNNA AIEYANIEV*WFDCMAVL*QPLVFFPIASFFKK LIKSLFIFPQSSMTRAILRRHCYLIFNLFK*KIP MFSSVVDAIV*PSPPNCIHWLGMFTTCVRGSGR RFPYSTLLLFCIK*IGKD*RLSFVSFSYPIAGL FYYAIMDIKACFLFRNFRNPICFF*GTL*QK*LT *ACCIKSLLLFLT*DTQSYVNNLVKYLYT**HF ESTLITESFI*VFYLLF*SSVSERLCTCFLLYF INGLLTLLY*FCILS*LSSSPSGNQL*HRNRAAQ ENSL*NNFFEFFLELHLEFWPLEFGLYKH*EYL NV*FFYSINSCTVYQIT*YSFTFNLYWPEKNNT GTLLLKDIINYSYTAFIFIPACSIFPCIHRSFIY NDKTKA*GFVLNLHCGREEKVLLRKPGF*FCHC L*LNRLVIHGKSLHWHFVYSSVS*TR**LQFKN FCNHYTKLVGNIKGIFLK**E*ILSTLYAIETLC FYIQTHLNGLREASKLAQD*KGSN*WAKILPMF LFGVSKPPHHF*KNSI*INKCFGDGVCRPGGGQ WHDLGSLQPPASASRMAGTTGTHHHTPLIFVILV EMGFQHVGQAGLKLDLK*PHLPQPPKVLGLQA* ATAPGLRFLNINISFRLKQRIFLKCHPIRC*VM LCMLSLVLSRSILKSQH*VFTKYLALF*TILLAH IIITVFSFPNF*NKLTGTLYKKCKIFFCTEESV YKNQYVLFNIRTHDSFCHCEKTWFLSCTPLCCD SNNLH*YDVFR*KTENSVIPSLEIRSGILLAGVI VQRSENSSM*FLDLISSIMISSIMAFFQAWSNF SENGHYLQASIVHVVSVAGERLFSSQCPCQFPK RTE*PCWFWSQP*SNLYFQGNGVLCLPALGSKRG TCYGHLCEDYIRKDSLQKTWTEEI*QMSIKSGS HTSYNT*MFDFSEYFAITGVASCPWIYLHSAVE CRGLSEGHIHPVLS*C*PLRVLRGMELKKELLPA VN*PS*SSLTQRKGDCDTHG*F*LHV*DFVIWV GNIPNAV*NTY*N*GTQERTGSSLVPKFLIVGI GILRV*AIHA*YSVIYHVDHLISNFLGWGFSCF* ILHFQFLLCLKYRLLTIVLNTNKYIKCILNT

Sequence NM_001031732

GTAAACAGCGCAGGGCATTTCGGGAGCGGGATTGTTTCGCGCAGGAAGCAGGCTCCATTTTAGCGCCGCCCGCCGTCGCCATCTGTTTCCCTTCCCTCCC CCATACCTAGCCCGAGTCTGAGCCCTAACGAGAAGGCTGGGCCTAGGCCGCTGGATGCTGGAGTGAAAGGAAGGGAGAAAGGGAAAAAGCGGGAAGAGTC GAGAAGGCTGAGTGTTAAGAGGCCAAGTGCGACGCGCGTATCCGGGCAGACGGACTGACGGACGGGCCCGTGCTTCTGCCGCGGCTGCGGCGCCCGCGCG AGTCGCGTCTAAGCGGCGGCGGCGGTGGCAGCGGCGGAAACCGAAGGGGAGCCATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCT GGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTGTATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGT GATCGAATGGAATCTACTGATACCAAACGACAAAAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAA GAATAGTTAGTACAAAAGGAAAGTCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCG TCTATCAAGTAGTGCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCA GATGGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGCTCTGACC ATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAGGAAGATGAAGAAGTAGA AGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAGGAGGAAGAAGAAGAA TATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCCAGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATG GGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGATGAGAAAAAGAAGGAAAGGAAGAGAGCTAGAGGCATATCTCCAATTGTTTTTGATAGAAGTGG AAGCTCTGCATCAGAGTCATATGCAGGTTCAGAAAAGAAGCATGAGAAATTATCATCTTCCGTTCGTGCTGTCCGAAAAGATCAAACCAGTAAACTCAAA TATGTGCTTCAAGATGCAAGATTTTTCCTCATAAAGAGTAACAACCATGAGAATGTGTCTCTTGCCAAAGCGAAGGGTGTATGGTCCACGCTCCCTGTAA ATGAGAAGAAATTAAATCTTGCATTTAGATCTGCAAGGAGTGTTATCTTAATATTTTCTGTCAGAGAGAGTGGAAAATTTCAAGGGTTTGCAAGACTTTC TTCAGAATCACATCACGGAGGATCTCCTATACACTGGGTGCTTCCAGCAGGAATGAGTGCTAAAATGCTGGGAGGTGTCTTTAAAATTGACTGGATTTGC AGGCGTGAATTACCCTTCACTAAGTCGGCTCATCTCACCAATCCTTGGAATGAACATAAACCAGTAAAGATCGGACGTGATGGACAGGAAATTGAACTTG AATGTGGAACCCAGCTTTGTCTTCTGTTTCCCCCCGATGAAAGTATTGACTTGTATCAGGTCATTCATAAAATGCGTCACAAGAGAAGAATGCATTCTCA GCCCCGATCACGAGGACGTCCATCCCGTCGAGAACCAGTCCGGGATGTGGGAAGGCGTCGACCAGAAGATTATGATATTCATAACAGCAGAAAGAAACCA AGGATTGACTATCCCCCTGAGTTTCACCAGAGACCAGGGTATTTAAAGGATCCACGATACCAGGAAGTGGACAGACGATTTTCAGGAGTTCGCCGAGATG TGTTTTTAAATGGGTCCTACAATGATTATGTGAGGGAATTTCATAACATGGGACCACCACCACCTTGGCAAGGAATGCCCCCTTACCCAGGAATGGAACA ACCTCCACACCATCCTTACTATCAGCACCATGCTCCACCTCCTCAAGCTCATCCCCCTTACTCAGGACATCATCCAGTACCACATGAAGCAAGATACAGA GATAAACGAGTACATGATTATGATATGAGGGTGGATGATTTCCTTCGTCGCACACAAGCTGTTGTCAGTGGCCGGAGAAGTAGACCCCGTGAAAGAGACC GGGAACGAGAGCGAGACCGCCCTAGAGATAACAGACGAGACAGAGAGCGAGATAGAGGACGTGATAGAGAAAGAGAAAGAGAGCGATTATGTGATCGAGA CAGAGACCGAGGGGAGAGAGGTCGATATAGAAGATAATGGGCTTTTGGAAGCACTGATTGTTTAAAGATACAAAAAATCTTGTATTTTTTTTTTGTGTGT GTTTACAAGTAGTAAATTTATTTTCAGCTGTCTGCCTATGAAGTTCATTGTGTAGAAGGATTTATTATGACCCCCTTTGTTCCAAGCATGCAGTATCATA AGAACTGGAAAAACTCAAATCCGCCAAAAATCCACAGCTGACAGTTGAATTGACACTTTTATTGGGGCAGAATGGAACAGTCCAAGAATGTAGATACTGA TTCTTTCTCCATAAATGTTCTTATAGTGTGTTCATCCTAGAGTTATTTTTTTGTTTGTTTTTTTCCTTTTTGGATCTTGATTGATAACTGCCATGATATT TTGCTTTGATGTGTTTCTACATGTAGTTGCACACGGTTCAGTAAAAATAATGCTGCTATCGAGTATGCAAATATTGAAGTATGATGGTTTGACTGTATGG CAGTGTTGTAGCAGCCTCTTGTTTTTTTCCCCATTGCCTCTTTTTTTAAAAAACTTATAAAGTCACTTTTTATTTTTCCTCAGTCTTCAATGACGAGAGC AATATTAAGAAGACATTGCTATCTAATTTTTAATCTTTTTAAATGAAAAATTCCTATGTTCAGTAGCGTGGTTGATGCTATTGTTTAGCCTTCCCCTCCA AATTGTATACATTGGCTTGGAATGTTCACAACTTGCGTGCGTGGCAGCGGAAGACGATTCCCATATTCTACATTGCTACTGTTTTGTATAAAATAAATTG GTAAAGATTGACGGTTATCTTTTGTATCTTTTTCTTATCCAATTGCAGGTTTGTTTTATTATGCAATAATGGACATAAAAGCATGCTTTTTGTTCAGGAA TTTTAGGAACCCCATTTGCTTTTTTTGAGGCACACTTTAGCAGAAATGATTGACCTAGGCCTGTTGCATTAAAAGCTTACTTCTATTTCTAACATAAGAT ACACAGAGTTATGTTAATAATTTGGTTAAGTATTTATACACCTGATAACATTTTGAGTCTACTCTGATCACAGAATCGTTTATTTAGGTTTTCTATTTGT TGTTTTAGTCTTCTGTAAGTGAACGACTTTGTACATGCTTTCTACTTTACTTCATAAATGGACTTTTAACCCTCTTGTATTAGTTCTGTATTTTAAGTTA ACTGTCCAGTTCTCCCAGTGGTAACCAACTATAACATAGAAATAGAGCCGCTCAAGAAAACAGTTTATGAAATAATTTTTTTGAATTTTTTCTTGAGTTA CACCTGGAGTTTTGGCCTTTGGAATTTGGCCTTTATAAACATTAGGAATATTTGAATGTTTGATTTTTTTATAGTATCAACAGTTGTACTGTGTACCAGA TCACATAGTACAGTTTTACATTTAATCTATATTGGCCTGAAAAGAACAACACAGGCACTTTACTCTTAAAGGATATAATAAACTATAGTTATACTGCATT CATATTCATACCAGCATGTAGTATCTTTCCCTGCATTCACAGAAGTTTTATTTACAATGACAAAACTAAAGCCTGAGGATTTGTTTTAAATCTGCATTGT GGTAGAGAGGAAAAAGTACTTTTAAGGAAACCTGGGTTCTAGTTTTGTCATTGTCTTTAATTAAACCGGTTAGTGATACATGGTAAGTCACTTCATTGGC ATTTTGTGTATTCATCAGTAAGCTAGACAAGATGATAGCTACAGTTTAAGAATTTCTGTAACCATTATACAAAACTGGTAGGTAATATTAAAGGTATTTT CCTGAAATAATAGGAATAAATACTGAGCACTTTGTATGCAATAGAGACTTTGTGCTTTTATATACAGACTCATTTAAATGGGCTCAGAGAGGCTAGTAAA CTTGCCCAAGATTAGAAAGGTAGTAATTGATGGGCCAAGATTTTACCCATGTTTTTATTTGGTGTTTCTAAACCACCTCATCACTTTTGAAAAAACAGTA TATAAATTAATAAATGTTTTGGAGATGGAGTCTGTCGCCCAGGTGGAGGGCAGTGGCATGATCTTGGCTCACTGCAACCTCCTGCCTCAGCCTCCCGAAT GGCTGGGACTACAGGCACCCACCACCACACCCCGCTAATTTTTGTAATTTTAGTAGAGATGGGGTTCCAACATGTTGGCCAGGCTGGTCTCAAACTCGAC CTCAAGTGACCTCACCTGCCTCAGCCTCCTAAAGTGTTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGAGATTTTTAAACATTAACATTTCCTTCA GGCTTAAGCAGAGGATTTTTCTAAAGTGCCATCCAATTAGATGTTAAGTTATGCTTTGTATGTTGAGCTTAGTATTGAGTCGATCTATTTTAAAAAGCCA ACATTAAGTTTTTACCAAGTATCTGGCACTATTCTAAACAATTCTGTTGGCTCACATAATCATCACTGTTTTCTCCTTTCCTAATTTTTAAAATAAACTT ACCGGAACATTGTATAAAAAATGCAAGATTTTTTTCTGTACAGAAGAGTCAGTATATAAAAATCAGTATGTTTTATTTAATATTCGTACACATGACAGCT TTTGTCACTGTGAGAAGACATGGTTTCTTTCGTGTACTCCACTGTGCTGTGATTCTAACAATCTACATTAGTATGATGTGTTCAGATGAAAAACAGAAAA TTCAGTCATTCCGAGTTTAGAAATCCGGTCAGGGATTTTATTGGCTGGAGTAATAGTTCAAAGGAGTGAAAATTCAAGCATGTAATTTTTGGATTTGATT TCCTCCATAATGATTTCCTCCATAATGGCTTTTTTTCAAGCATGGTCTAATTTTTCAGAAAATGGCCATTATCTCCAAGCTTCCATTGTCCATGTAGTTT CAGTGGCAGGAGAGAGACTATTTTCCTCCCAGTGTCCATGTCAGTTCCCCAAAAGGACTGAATAGCCATGTTGGTTTTGGAGCCAGCCGTAATCCAATCT GTATTTCCAAGGAAATGGGGTTCTTTGTCTCCCAGCATTGGGAAGCAAGAGAGGCACATGTTATGGTCACCTCTGTGAGGATTACATCAGGAAGGACAGT CTCCAAAAGACATGGACAGAGGAAATTTAGCAGATGTCCATTAAATCAGGATCTCATACAAGTTATAACACCTGAATGTTTGACTTTTCAGAGTATTTTG CCATCACAGGTGTGGCATCTTGCCCTTGGATATATCTACATTCTGCTGTAGAATGTCGTGGTCTTTCTGAGGGTCACATACATCCTGTCTTGTCATAATG TTAACCATTAAGAGTCCTCAGGGGCATGGAATTGAAGAAGGAACTGTTGCCAGCAGTTAACTGACCAAGCTAGAGTTCCCTGACCCAACGTAAGGGTGAC TGTGACACACATGGATAATTTTAGCTTCATGTTTAAGATTTTGTTATTTGGGTAGGAAACATTCCAAATGCAGTTTGAAACACATATTAAAATTGAGGCA CACAGGAAAGAACTGGCTCAAGTTTAGTCCCCAAGTTCCTTATAGTAGGAATAGGAATCCTTAGAGTATAAGCAATCCATGCATAGTATTCTGTTATCTA TCATGTAGATCATTTAATCTCTAATTTTTTGGGGTGGGGATTCTCTTGTTTCTAAATCTTACACTTTCAGTTTCTTCTGTGTCTTAAATATAGATTATTG ACTATTGTCTTAAATACTAATAAATACATTAAATGTATCTTAAATACTA

refseq_YTHDC1.F1 (forward primer)
refseq_YTHDC1.R1 (reverse primer)
Single exon skipping

Frame 0

VNSAGHFGSGIVSRRKQAPF*RRPPSPSVSLPS PIPSPSLSPNEKAGPRPLDAGVKGREKGKKREES RRLSVKRPSATRVSGQTD*RTGPCFCRGCGARA SRV*AAAAVAAAETEGEPWRLTVGRRKMENLMF WMIF*LKYQNKMMNCIIQRVNKIKMRKRDQKEKV IEWNLLIPNDKSLLSILDNWFLSH*AHLLAITK E*LVQKESQPQSIKMRNIKDLKETSV*MLIGKF VYQVVPPENLIRINLKKPVSGKGILKGGPNLLRQ MVLRELGLKWIDVQADPASLLRKK*TLKNMALT MRLAAVVLLMSKGTTLRMRRKEWKKMWRKMKK* KKMQKKMKRWMKMERRRRKRRRRKRRRRRRKKKN MNRMRETRKRREMIMTLEVRPVTLVLNLFPSQM GLSDLVQAQMDQMRKRRKGRELEAYLQLFLIEV EALHQSHMQVQKRSMRNYHLPFVLSEKIKPVNSN MCFKMQDFSS*RVTTMRMCLLPKRRVYGPRSL* MRRN*ILHLDLQGVLS*YFLSERVENFKGLQDF LQNHITEDLLYTGCFQQE*VLKCWEVSLKLTGFA GVNYPSLSRLISPILGMNINQ*RSDVMDRKLNL NVEPSFVFCFPPMKVLTCIRSFIKCVTREECIL SPDHEDVHPVENQSGMWEGVDQKIMIFITAERNQ GLTIPLSFTRDQGI*RIHDTRKWTDDFQEFAEM CF*MGPTMIM*GNFITWDHHHLGKECPLTQEWN NLHTILTISTMLHLLKLIPLTQDIIQYHMKQDTE INEYMIMI*GWMISFVAHKLLSVAGEVDPVKET GNESETALEITDETESEIEDVIEKEKESDYVIE TETEGREVDIEDNGLLEALIV*RYKKSCIFFLCV FTSSKFIFSCLPMKFIV*KDLL*PPLFQACSII RTGKTQIRQKSTADS*IDTFIGAEWNSPRM*IL ILSP*MFL*CVHPRVIFLFVFFLFGS*LITAMIF CFDVFLHVVAHGSVKIMLLSSMQILKYDGLTVW QCCSSLLFFSPLPLFLKNL*SHFLFFLSLQ*RE QY*EDIAI*FLIFLNEKFLCSVAWLMLLFSLPLQ IVYIGLECSQLACVAAEDDSHILHCYCFV*NKL VKIDGYLLYLFLIQLQVCFIMQ*WT*KHAFCSG ILGTPFAFFEAHFSRND*PRPVALKAYFYF*HKI HRVMLIIWLSIYTPDNILSLL*SQNRLFRFSIC CFSLL*VNDFVHAFYFTS*MDF*PSCISSVF*V NCPVLPVVTNYNIEIEPLKKTVYEIIFLNFFLSY TWSFGLWNLAFINIRNI*MFDFFIVSTVVLCTR SHSTVLHLIYIGLKRTTQALYS*RI**TIVILH SYSYQHVVSFPAFTEVLFTMTKLKPEDLF*ICIV VERKKYF*GNLGSSFVIVFN*TG**YMVSHFIG ILCIHQ*ARQDDSYSLRISVTIIQNW*VILKVF S*NNRNKY*ALCMQ*RLCAFIYRLI*MGSERLVN LPKIRKVVIDGPRFYPCFYLVFLNHLITFEKTV YKLINVLEMESVAQVEGSGMILAHCNLLPQPPE WLGLQAPTTTPR*FL*F**RWGSNMLARLVSNST SSDLTCLSLLKCWDYRREPLHLA*DF*TLTFPS GLSRGFF*SAIQLDVKLCFVC*A*Y*VDLF*KA NIKFLPSIWHYSKQFCWLT*SSLFSPFLIFKINL PEHCIKNARFFSVQKSQYIKISMFYLIFVHMTA FVTVRRHGFFRVLHCAVILTIYISMMCSDEKQK IQSFRV*KSGQGFYWLE**FKGVKIQACNFWI*F PP**FPP*WLFFKHGLIFQKMAIISKLPLSM*F QWQERDYFPPSVHVSSPKGLNSHVGFGASRNPI CISKEMGFFVSQHWEAREAHVMVTSVRITSGRTV SKRHGQRKFSRCPLNQDLIQVITPECLTFQSIL PSQVWHLALGYIYILL*NVVVFLRVTYILSCHN VNH*ESSGAWN*RRNCCQQLTDQARVP*PNVRVT VTHMDNFSFMFKILLFG*ETFQMQFETHIKIEA HRKELAQV*SPSSL**E*ESLEYKQSMHSILLS IM*II*SLIFWGGDSLVSKSYTFSFFCVLNIDY* LLS*ILINTLNVS*IL

Frame 1

*TAQGISGAGLFRAGSRLHFSAARRRHLFPFPP PYLARV*ALTRRLGLGRWMLE*KEGRKGKSGKS REG*VLRGQVRRAYPGRRTDGRARASAAAAAPAR VASKRRRRWQRRKPKGSHGG*QSGGERWRT*CS G*YFN*STRTR**TV*SRE*TR*K*EKGIKKKK *SNGIY*YQTTKAFCPF*TTGF*ATELIC*Q*QK NS*YKRKVSHRV*K*GISKI*KKQASRC*SENS SIK*CLQRTL*EST*KNLCPEKGS*KEGQISYA RWF*ENWA*SG*TCKQIQPVF*GRSEL*RIWL*P *DWQQWFF**AREQH*E*GGRSGRRCGGR*RSR RRCRRR*RGG*RWRGGGGRGGGGRGGGGGGRRR I*TG*ERPERGGK*L*HSK*GQ*LWF*ICFLHRW VCQIWFRHRWIR*EKEGKEES*RHISNCF**KW KLCIRVICRFRKEA*EIIIFRSCCPKRSNQ*TQ ICASRCKIFPHKE*QP*ECVSCQSEGCMVHAPCK *EEIKSCI*ICKECYLNIFCQREWKISRVCKTF FRITSRRISYTLGASSRNEC*NAGRCL*N*LDL QA*ITLH*VGSSHQSLE*T*TSKDRT*WTGN*T* MWNPALSSVSPR*KY*LVSGHS*NASQEKNAFS APITRTSIPSRTSPGCGKASTRRL*YS*QQKET KD*LSP*VSPETRVFKGSTIPGSGQTIFRSSPRC VFKWVLQ*LCEGIS*HGTTTTLARNAPLPRNGT TSTPSLLSAPCSTSSSSSPLLRTSSSTT*SKIQ R*TST*L*YEGG*FPSSHTSCCQWPEK*TP*KRP GTRARPP*R*QTRQRAR*RT**RKRKRAIM*SR QRPRGERSI*KIMGFWKH*LFKDTKNLVFFFCV CLQVVNLFSAVCL*SSLCRRIYYDPLCSKHAVS* ELEKLKSAKNPQLTVELTLLLGQNGTVQECRY* FFLHKCSYSVFILELFFCLFFSFLDLD**LP*Y FALMCFYM*LHTVQ*K*CCYRVCKY*SMMV*LYG SVVAASCFFPHCLFF*KTYKVTFYFSSVFNDES NIKKTLLSNF*SF*MKNSYVQ*RG*CYCLAFPS KLYTLAWNVHNLRAWQRKTIPIFYIATVLYKINW *RLTVIFCIFFLSNCRFVLLCNNGHKSMLFVQE F*EPHLLFLRHTLAEMIDLGLLH*KLTSISNIR YTELC**FG*VFIHLITF*VYSDHRIVYLGFLFV VLVFCK*TTLYMLSTLLHKWTFNPLVLVLYFKL TVQFSQW*PTIT*K*SRSRKQFMK*FF*IFS*V TPGVLAFGIWPL*TLGIFECLIFL*YQQLYCVPD HIVQFYI*SILA*KEQHRHFTLKGYNKL*LYCI HIHTSM*YLSLHSQKFYLQ*QN*SLRICFKSAL W*RGKSTFKETWVLVLSLSLIKPVSDTW*VTSLA FCVFISKLDKMIATV*EFL*PLYKTGR*Y*RYF PEIIGINTEHFVCNRDFVLLYTDSFKWAQRG** TCPRLER**LMGQDFTHVFIWCF*TTSSLLKKQY IN**MFWRWSLSPRWRAVA*SWLTATSCLSLPN GWDYRHPPPHPANFCNFSRDGVPTCWPGWSQTR PQVTSPASAS*SVGITGVSHCTWPEIFKH*HFLQ A*AEDFSKVPSN*MLSYALYVELSIESIYFKKP TLSFYQVSGTILNNSVGSHNHHCFLLS*FLK*T YRNIV*KMQDFFLYRRVSI*KSVCFI*YSYT*QL LSL*EDMVSFVYSTVL*F*QSTLV*CVQMKNRK FSHSEFRNPVRDFIGWSNSSKE*KFKHVIFGFD FLHNDFLHNGFFSSMV*FFRKWPLSPSFHCPCSF SGRRETIFLPVSMSVPQKD*IAMLVLEPAVIQS VFPRKWGSLSPSIGKQERHMLWSPL*GLHQEGQ SPKDMDRGNLADVH*IRISYKL*HLNV*LFRVFC HHRCGILPLDISTFCCRMSWSF*GSHTSCLVIM LTIKSPQGHGIEEGTVASS*LTKLEFPDPT*G* L*HTWIILASCLRFCYLGRKHSKCSLKHILKLRH TGKNWLKFSPQVPYSRNRNP*SISNPCIVFCYL SCRSFNL*FFGVGILLFLNLTLSVSSVS*I*II DYCLKY**IH*MYLKY

Frame 2

KQRRAFRERDCFAQEAGSILAPPAVAICFPSLP HT*PESEP*REGWA*AAGCWSERKGEREKAGRV EKAEC*EAKCDARIRADGLTDGPVLLPRLRRPR ESRLSGGGGGSGGNRRGAMAADSREEKDGELNVL DDILTEVPEQDDELYNPESEQDKNEKKGSKRKS DRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNK RIVSTKGKSATEYKNEEYQRSERNKRLDADRKIR LSSSASREPYKNQPEKTCVRKRDPERRAKSPTP DGSERIGLEVDRRASRSSQSSKEEVNSEEYGSD HETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVE EDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE YEQDERDQKEEGNDYDTRSEASDSGSESVSFTD GSVRSGSGTDGSDEKKKERKRARGISPIVFDRSG SSASESYAGSEKKHEKLSSSVRAVRKDQTSKLK YVLQDARFFLIKSNNHENVSLAKAKGVWSTLPV NEKKLNLAFRSARSVILIFSVRESGKFQGFARLS SESHHGGSPIHWVLPAGMSAKMLGGVFKIDWIC RRELPFTKSAHLTNPWNEHKPVKIGRDGQEIEL ECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQ PRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKP RIDYPPEFHQRPGYLKDPRYQEVDRRFSGVRRD VFLNGSYNDYVREFHNMGPPPPWQGMPPYPGMEQ PPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYR DKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERD RERERDRPRDNRRDRERDRGRDRERERERLCDRD RDRGERGRYRR*WAFGSTDCLKIQKILYFFFVC VYK**IYFQLSAYEVHCVEGFIMTPFVPSMQYH KNWKNSNPPKIHS*QLN*HFYWGRMEQSKNVDTD SFSINVLIVCSS*SYFFVCFFPFWILIDNCHDI LL*CVSTCSCTRFSKNNAAIEYANIEV*WFDCM AVL*QPLVFFPIASFFKKLIKSLFIFPQSSMTRA ILRRHCYLIFNLFK*KIPMFSSVVDAIV*PSPP NCIHWLGMFTTCVRGSGRRFPYSTLLLFCIK*I GKD*RLSFVSFSYPIAGLFYYAIMDIKACFLFRN FRNPICFF*GTL*QK*LT*ACCIKSLLLFLT*D TQSYVNNLVKYLYT**HFESTLITESFI*VFYL LF*SSVSERLCTCFLLYFINGLLTLLY*FCILS* LSSSPSGNQL*HRNRAAQENSL*NNFFEFFLEL HLEFWPLEFGLYKH*EYLNV*FFYSINSCTVYQ IT*YSFTFNLYWPEKNNTGTLLLKDIINYSYTAF IFIPACSIFPCIHRSFIYNDKTKA*GFVLNLHC GREEKVLLRKPGF*FCHCL*LNRLVIHGKSLHW HFVYSSVS*TR**LQFKNFCNHYTKLVGNIKGIF LK**E*ILSTLYAIETLCFYIQTHLNGLREASK LAQD*KGSN*WAKILPMFLFGVSKPPHHF*KNS I*INKCFGDGVCRPGGGQWHDLGSLQPPASASRM AGTTGTHHHTPLIFVILVEMGFQHVGQAGLKLD LK*PHLPQPPKVLGLQA*ATAPGLRFLNINISF RLKQRIFLKCHPIRC*VMLCMLSLVLSRSILKSQ H*VFTKYLALF*TILLAHIIITVFSFPNF*NKL TGTLYKKCKIFFCTEESVYKNQYVLFNIRTHDS FCHCEKTWFLSCTPLCCDSNNLH*YDVFR*KTEN SVIPSLEIRSGILLAGVIVQRSENSSM*FLDLI SSIMISSIMAFFQAWSNFSENGHYLQASIVHVV SVAGERLFSSQCPCQFPKRTE*PCWFWSQP*SNL YFQGNGVLCLPALGSKRGTCYGHLCEDYIRKDS LQKTWTEEI*QMSIKSGSHTSYNT*MFDFSEYF AITGVASCPWIYLHSAVECRGLSEGHIHPVLS*C *PLRVLRGMELKKELLPAVN*PS*SSLTQRKGD CDTHG*F*LHV*DFVIWVGNIPNAV*NTY*N*G TQERTGSSLVPKFLIVGIGILRV*AIHA*YSVIY HVDHLISNFLGWGFSCF*ILHFQFLLCLKYRLL TIVLNTNKYIKCILNT