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Sequences

Sequence NM_021721

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG
TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG
AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT
GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT
CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA
TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA
AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA
AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA
TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA
TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC
ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG
GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT
AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC
TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC
TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG
TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA
AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA
TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA
TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT
ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA
AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT
CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA
GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA
TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGGTCAAATGGGCTCTCTCATTC
TTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAGGCAACAAA
AAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGTAAGTCTGAACCTCTAATGGAAAAAGGCACTCCAAGGTCCTGTGCAAATAGT
GTCAAAAGTAAATTAAGCAGATAGTCAAAGAACTGT
  • refseq_ADAM22.F3 (forward primer)
  • refseq_ADAM22.R3 (reverse primer)
  • Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC
VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG
KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG
AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK
S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY
PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR
K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS
KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH
*TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR
FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID
HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER
GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI
SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW
LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A
S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL
*EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS
K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN
LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE
Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ
YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC*
A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF
QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD
RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH
NCWHHFSAGPHIRNNCVGL*KLSRTEVKWALSF
LE*KDSRHKTYFRHL*KWATSK*LLAR*PGRQQ
KENQRQKI*TSV*FN*VSLNL*WKKALQGPVQIV
SKVN*ADSQRT

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV
SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK
ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV
RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN
HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE
NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV
NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD
LIYKDQLKTRIVLVAMETWATDNKFAISENPLI
TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS
GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL
AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG
YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK
LLDPPECGNGFIETGEECDCGTPAECVLEGAECC
KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV
NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN
IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN
IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV
KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF
NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI
GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG
IIAGTILVLALILGITAWGYKNYREQRSNGLSHS
WSERIPDTKHISDICENGRPRSNSWQGNLGGNK
KKIRGKRFRPRSNSTE*V*TSNGKRHSKVLCK*
CQK*IKQIVKEL

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC
PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR
KTASWSARASCHCASSTARAAKTKVGTTRSTRG
CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I
MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI
SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK
KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK*
TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT
LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ
I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S
PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA
GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH
*PIILVLSQTKES*QVVNVNARTRGPGA*WETLA
IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS
FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV
VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ*
MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE
FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN*
ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI
LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML
SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL
STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG*
VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A
*LLAPF*CWPSY*E*LRGVIKTIENRGQMGSLI
LGVKGFQTQNIFQTSVKMGDLEVTLGKVTWEATK
RKSEAKDLDLGLIQLSKSEPLMEKGTPRSCANS
VKSKLSR*SKNC

Sequence NM_016351

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG
TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG
AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT
GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT
CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA
TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA
AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA
AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA
TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA
TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC
ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG
GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT
AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC
TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC
TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG
TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA
AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA
TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA
TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT
ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA
AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT
CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA
GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA
TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGGTCAAATGGGCTCTCTCATTC
TTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAGGCAACAAA
AAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTATTGCCTCCA
GCAGAAAATACCCTTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAAGATCAACT
GTTTACATGTGATACATCGAAAACTGTTTACTTCAACTTTTATAGAAACCCAGGCTCATGGAATCACTGCAAATCTATCTGCTCTTCAGACAATACGAAG
ACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCATTTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATGAAAAGAAC
TACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGGATAATCCGCATGACAGATAATATGTAGAAATATTCATAAAGTTAAC
TCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACTTGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATGCTATATGC
ATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAGAAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCTGCAGGACT
TTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTATTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGCATACAAGG
ACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA
  • refseq_ADAM22.F3 (forward primer)
  • refseq_ADAM22.R3 (reverse primer)
  • Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC
VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG
KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG
AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK
S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY
PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR
K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS
KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH
*TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR
FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID
HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER
GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI
SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW
LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A
S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL
*EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS
K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN
LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE
Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ
YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC*
A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF
QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD
RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH
NCWHHFSAGPHIRNNCVGL*KLSRTEVKWALSF
LE*KDSRHKTYFRHL*KWATSK*LLAR*PGRQQ
KENQRQKI*TSV*FN*DFISCQVSFFINWVYCLQ
QKIPLPNASTS**GQESEPTKCQAMGDIHLRST
VYM*YIENCLLQLL*KPRLMESLQIYLLFRQYE
DPLRCYRGEEAEFHIWLPFSFCHWLRI*LTMKRT
TEILHYNMEQ*RYWYVNG*SA*QIICRNIHKVN
SHDPNVASFLRYNSGFRT*RSEAHPHCKQ*CYM
HEASVYCFPYLRKQHPIIEMSMQG*GI*DFSAGL
*SFERPISHRLTLNMYFYFCFVFYFSYLY*HTR
TIVYM*HF*NFKK

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV
SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK
ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV
RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN
HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE
NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV
NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD
LIYKDQLKTRIVLVAMETWATDNKFAISENPLI
TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS
GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL
AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG
YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK
LLDPPECGNGFIETGEECDCGTPAECVLEGAECC
KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV
NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN
IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN
IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV
KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF
NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI
GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG
IIAGTILVLALILGITAWGYKNYREQRSNGLSHS
WSERIPDTKHISDICENGRPRSNSWQGNLGGNK
KKIRGKRFRPRSNSTETLSPAKSPSSSTGSIAS
SRKYPYPMPPLPDEDKKVNRQSARLWETSI*DQL
FTCDTSKTVYFNFYRNPGSWNHCKSICSSDNTK
TL*DATEERKRSFTSGYHFLFVIGLGFN*P*KE
LLKYYTITWNNKGTGMLMDNPHDR*YVEIFIKLT
HMTQM*QVS*GTIVDSELDVLRHILTVNSNAIC
MKLLFIVFHI*GNNIP**K*ACRAKAYRIFLQD
FKALKGQYPIG*L*TCIFIFVLFFTFHIYISIQG
QLYICNIFKILKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC
PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR
KTASWSARASCHCASSTARAAKTKVGTTRSTRG
CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I
MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI
SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK
KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK*
TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT
LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ
I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S
PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA
GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH
*PIILVLSQTKES*QVVNVNARTRGPGA*WETLA
IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS
FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV
VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ*
MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE
FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN*
ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI
LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML
SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL
STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG*
VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A
*LLAPF*CWPSY*E*LRGVIKTIENRGQMGSLI
LGVKGFQTQNIFQTSVKMGDLEVTLGKVTWEATK
RKSEAKDLDLGLIQLRLYLLPSLLLHQLGLLPP
AENTLTQCLHFLMRTRK*TDKVPGYGRHPFKIN
CLHVIHRKLFTSTFIETQAHGITANLSALQTIRR
PSEMLQRRGSGVSHLVTIFFLSLA*DLTNHEKN
Y*NITL*HGTIKVLVC*WIIRMTDNM*KYS*S*
LT*PKCSKFPKVQ*WIQNLTF*GTSSL*TVMLYA
*SFCLLFSIFKETTSHNRNEHAGLRHIGFFCRT
LKL*KANIP*ANFKHVFLFLFCFLLFIFILAYK
DNCIYVTFLKF*K

Sequence NM_021722

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG
TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG
AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT
GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT
CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA
TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA
AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA
AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA
TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA
TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC
ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG
GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT
AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC
TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC
TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG
TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA
AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA
TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA
TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT
ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA
AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT
CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA
GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA
TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGGTCAAATGGGCTCTCTCATTC
TTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAGGCAACAAA
AAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGTATTTAAACCCATGGTTCAAAAGAGACTATAATGTAGCTAAGTGGGTAGAAG
ATGTGAATAAAAACACTGAAGGACCATACTTTAGGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTATTGCCTCCAGCAGAAAATACCC
TTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAAGATCAACTGTTTACATGTGAT
ACATCGAAAACTGTTTACTTCAACTTTTACTTCAGACAATACGAAGACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCAT
TTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATGAAAAGAACTACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGG
ATAATCCGCATGACAGATAATATGTAGAAATATTCATAAAGTTAACTCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACT
TGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATGCTATATGCATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAG
AAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCTGCAGGACTTTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTA
TTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGCATACAAGGACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA
  • refseq_ADAM22.F3 (forward primer)
  • refseq_ADAM22.R3 (reverse primer)
  • Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC
VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG
KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG
AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK
S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY
PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR
K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS
KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH
*TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR
FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID
HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER
GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI
SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW
LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A
S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL
*EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS
K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN
LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE
Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ
YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC*
A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF
QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD
RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH
NCWHHFSAGPHIRNNCVGL*KLSRTEVKWALSF
LE*KDSRHKTYFRHL*KWATSK*LLAR*PGRQQ
KENQRQKI*TSV*FN*VFKPMVQKRL*CS*VGRR
CE*KH*RTIL*DFISCQVSFFINWVYCLQQKIP
LPNASTS**GQESEPTKCQAMGDIHLRSTVYM*
YIENCLLQLLLQTIRRPSEMLQRRGSGVSHLVTI
FFLSLA*DLTNHEKNY*NITL*HGTIKVLVC*W
IIRMTDNM*KYS*S*LT*PKCSKFPKVQ*WIQN
LTF*GTSSL*TVMLYA*SFCLLFSIFKETTSHNR
NEHAGLRHIGFFCRTLKL*KANIP*ANFKHVFL
FLFCFLLFIFILAYKDNCIYVTFLKF*K

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV
SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK
ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV
RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN
HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE
NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV
NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD
LIYKDQLKTRIVLVAMETWATDNKFAISENPLI
TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS
GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL
AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG
YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK
LLDPPECGNGFIETGEECDCGTPAECVLEGAECC
KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV
NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN
IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN
IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV
KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF
NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI
GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG
IIAGTILVLALILGITAWGYKNYREQRSNGLSHS
WSERIPDTKHISDICENGRPRSNSWQGNLGGNK
KKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE
DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYP
YPMPPLPDEDKKVNRQSARLWETSI*DQLFTCD
TSKTVYFNFYFRQYEDPLRCYRGEEAEFHIWLP
FSFCHWLRI*LTMKRTTEILHYNMEQ*RYWYVNG
*SA*QIICRNIHKVNSHDPNVASFLRYNSGFRT
*RSEAHPHCKQ*CYMHEASVYCFPYLRKQHPII
EMSMQG*GI*DFSAGL*SFERPISHRLTLNMYFY
FCFVFYFSYLY*HTRTIVYM*HF*NFKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC
PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR
KTASWSARASCHCASSTARAAKTKVGTTRSTRG
CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I
MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI
SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK
KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK*
TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT
LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ
I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S
PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA
GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH
*PIILVLSQTKES*QVVNVNARTRGPGA*WETLA
IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS
FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV
VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ*
MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE
FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN*
ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI
LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML
SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL
STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG*
VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A
*LLAPF*CWPSY*E*LRGVIKTIENRGQMGSLI
LGVKGFQTQNIFQTSVKMGDLEVTLGKVTWEATK
RKSEAKDLDLGLIQLSI*THGSKETIM*LSG*K
M*IKTLKDHTLGLYLLPSLLLHQLGLLPPAENT
LTQCLHFLMRTRK*TDKVPGYGRHPFKINCLHVI
HRKLFTSTFTSDNTKTL*DATEERKRSFTSGYH
FLFVIGLGFN*P*KELLKYYTITWNNKGTGMLM
DNPHDR*YVEIFIKLTHMTQM*QVS*GTIVDSEL
DVLRHILTVNSNAICMKLLFIVFHI*GNNIP**
K*ACRAKAYRIFLQDFKALKGQYPIG*L*TCIF
IFVLFFTFHIYISIQGQLYICNIFKILKK

Sequence NM_004194

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG
TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG
AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT
GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT
CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA
TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA
AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA
AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA
TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA
TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC
ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG
GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT
AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC
TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC
TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG
TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA
AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA
TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA
TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT
ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA
AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT
CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA
GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA
TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGACAGTTACCCCAGGGAGATTA
TGTAAAAAAGCCTGGAGATGGTGACTCTTTTTATAGCGACATTCCTCCCGGAGTCAGCACAAACTCAGCATCTAGTTCTAAGAAGAGGTCAAATGGGCTC
TCTCATTCTTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAG
GCAACAAAAAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGTAAGTCTGAACCTCTAATGGAAAAAGGCACTCCAAGGTCCTGTG
CAAATAGTGTCAAAAGTAAATTAAGCAGATAGTCAAAGAACTGT
  • refseq_ADAM22.F3 (forward primer)
  • refseq_ADAM22.R3 (reverse primer)
  • Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC
VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG
KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG
AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK
S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY
PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR
K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS
KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH
*TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR
FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID
HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER
GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI
SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW
LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A
S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL
*EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS
K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN
LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE
Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ
YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC*
A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF
QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD
RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH
NCWHHFSAGPHIRNNCVGL*KLSRTETVTPGRL
CKKAWRW*LFL*RHSSRSQHKLSI*F*EEVKWA
LSFLE*KDSRHKTYFRHL*KWATSK*LLAR*PGR
QQKENQRQKI*TSV*FN*VSLNL*WKKALQGPV
QIVSKVN*ADSQRT

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV
SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK
ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV
RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN
HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE
NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV
NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD
LIYKDQLKTRIVLVAMETWATDNKFAISENPLI
TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS
GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL
AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG
YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK
LLDPPECGNGFIETGEECDCGTPAECVLEGAECC
KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV
NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN
IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN
IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV
KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF
NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI
GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG
IIAGTILVLALILGITAWGYKNYREQRQLPQGDY
VKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGL
SHSWSERIPDTKHISDICENGRPRSNSWQGNLG
GNKKKIRGKRFRPRSNSTE*V*TSNGKRHSKVLC
K*CQK*IKQIVKEL

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC
PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR
KTASWSARASCHCASSTARAAKTKVGTTRSTRG
CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I
MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI
SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK
KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK*
TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT
LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ
I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S
PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA
GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH
*PIILVLSQTKES*QVVNVNARTRGPGA*WETLA
IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS
FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV
VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ*
MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE
FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN*
ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI
LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML
SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL
STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG*
VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A
*LLAPF*CWPSY*E*LRGVIKTIENRDSYPREI
M*KSLEMVTLFIATFLPESAQTQHLVLRRGQMGS
LILGVKGFQTQNIFQTSVKMGDLEVTLGKVTWE
ATKRKSEAKDLDLGLIQLSKSEPLMEKGTPRSC
ANSVKSKLSR*SKNC

Sequence NM_021723

GCGGAGCGAGGGAAACGGACTCGGCGGCGCCGGCATGAGGAGCTGAGCGTCTCGGGCGAGGCGGGCTGACGGCAGCACCATGCAGGCGGCAGTGGCTGTG
TCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGCCCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAGG
AAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGCGGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGT
GCGGGGCGACCTCGGTGGCCCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTCATTCTCGATGTCGTGCTAAAT
CATGATTTGCTGTCCTCTGAATACATAGAGAGACACATTGAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCATA
TCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATGTTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGA
AAATGACACTACTCAAGAGGATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTTCCATCTGAATTTCAGCAAGTA
AACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCAAAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATACA
TTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTACATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGA
TTTAATATATAAAGACCAACTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCCATATCTGAAAATCCATTGATC
ACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATCAAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGCG
GGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTTGGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATT
AGCCCATAATATTGGTATTATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGGTGCATAATGGGAGACACTGGC
TATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAAGAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAGC
TTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGTGGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTG
TAAGAAATGCACCTTGACTCAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGCACTGTGTGCCGAGAAGCAGTA
AATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCAAGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGAA
TTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAAAAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAA
TATTGAAGGGACGGAGAAGGGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGTGGTTACCTTTTGTGTACCAAT
ATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAAATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTTA
AGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAAATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTT
CAACTTTAGTACTTGCTTGAGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGTGTGTGTAACAGACACTGGATA
GGTTCTGATTGCAACACTTACTTCCCTCACAATGATGATGCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGCA
TAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTATAAAAACTATCGAGAACAGAGACAGTTACCCCAGGGAGATTA
TGTAAAAAAGCCTGGAGATGGTGACTCTTTTTATAGCGACATTCCTCCCGGAGTCAGCACAAACTCAGCATCTAGTTCTAAGAAGAGGTCAAATGGGCTC
TCTCATTCTTGGAGTGAAAGGATTCCAGACACAAAACATATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGAG
GCAACAAAAAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAGACTTTATCTCCTGCCAAGTCTCCTTCTTCATCAACTGGGTCTAT
TGCCTCCAGCAGAAAATACCCTTACCCAATGCCTCCACTTCCTGATGAGGACAAGAAAGTGAACCGACAAAGTGCCAGGCTATGGGAGACATCCATTTAA
GATCAACTGTTTACATGTGATACATCGAAAACTGTTTACTTCAACTTTTATAGAAACCCAGGCTCATGGAATCACTGCAAATCTATCTGCTCTTCAGACA
ATACGAAGACCCTCTGAGATGCTACAGAGGAGAGGAAGCGGAGTTTCACATCTGGTTACCATTTTCTTTTTGTCATTGGCTTAGGATTTAACTAACCATG
AAAAGAACTACTGAAATATTACACTATAACATGGAACAATAAAGGTACTGGTATGTTAATGGATAATCCGCATGACAGATAATATGTAGAAATATTCATA
AAGTTAACTCACATGACCCAAATGTAGCAAGTTTCCTAAGGTACAATAGTGGATTCAGAACTTGACGTTCTGAGGCACATCCTCACTGTAAACAGTAATG
CTATATGCATGAAGCTTCTGTTTATTGTTTTCCATATTTAAGGAAACAACATCCCATAATAGAAATGAGCATGCAGGGCTAAGGCATATAGGATTTTTCT
GCAGGACTTTAAAGCTTTGAAAGGCCAATATCCCATAGGCTAACTTTAAACATGTATTTTTATTTTTGTTTTGTTTTTTACTTTTCATATTTATATTAGC
ATACAAGGACAATTGTATATATGTAACATTTTTAAAATTTTAAAAAAA
  • refseq_ADAM22.F3 (forward primer)
  • refseq_ADAM22.R3 (reverse primer)
  • Single exon skipping

Frame 0

AERGKRTRRRRHEELSVSGEAG*RQHHAGGSGC
VRALLAALCPGDLPSGALRPGRRRLIDGAREEEG
KPLRGAPEHRATAPHLPLGRRRRKSARRARHAG
AGRPRWPAVDSC*PSKLPG*CLWNVIHSRCRAK
S*FAVL*IHRETH*TWRQDCGS*RRRALLLPGPY
PRKP*LICCIVNMPRTSWDVL*REPHISH*ARR
K*HYSRGFPFSFSLQIQTV*IFLG*SSI*ISAS
KHYSIKIYFEAKTKKE*TAASSISS*CRRRNQIH
*TDDCE*SPYV*KTSAFRCTYQYLCEICGEHGR
FNI*RPT*DQDSIGCYGNLGD*QQVCHI*KSID
HPT*VYEIQEGFYQREK*CSSPFFGKSI*E*PER
GSLYWWDLLVAERRRRE*IWEN*FNGCYTCPVI
SP*YWYYLRQKKVSKW*M*MRGHVVRVHNGRHW
LLSS*KVHPV*Y*RVS*LPE*WRWCLPFQQTF*A
S*SS*VWQWLH*NWRGV*LWNPGRMCP*RSRVL
*EMHLDSRLSMQ*RSLL*KVQVSAYGHCVPRSS
K*L*YS*NVLRKFKPVCP*YS*NGWIFM*WCSGN
LLWRKMQNQR*TMQIHLGAKGDSIRQILL*ETE
Y*RDGEG*LWERQRHMDTVQQTGCALWLPFVYQ
YWQYPKAWRTRW*NHIYFSCAARKNIKLQWWAC*
A*RRCRSWLCGRWDTLWSPNDVLRTQVSSCGFF
QL*YLLEQ*RRHYLLRKWSLQ**AEVCV*QTLD
RF*LQHLLPSQ**CKDWYHSVWQWCCWHQYHNRH
NCWHHFSAGPHIRNNCVGL*KLSRTETVTPGRL
CKKAWRW*LFL*RHSSRSQHKLSI*F*EEVKWA
LSFLE*KDSRHKTYFRHL*KWATSK*LLAR*PGR
QQKENQRQKI*TSV*FN*DFISCQVSFFINWVY
CLQQKIPLPNASTS**GQESEPTKCQAMGDIHL
RSTVYM*YIENCLLQLL*KPRLMESLQIYLLFRQ
YEDPLRCYRGEEAEFHIWLPFSFCHWLRI*LTM
KRTTEILHYNMEQ*RYWYVNG*SA*QIICRNIH
KVNSHDPNVASFLRYNSGFRT*RSEAHPHCKQ*C
YMHEASVYCFPYLRKQHPIIEMSMQG*GI*DFS
AGL*SFERPISHRLTLNMYFYFCFVFYFSYLY*
HTRTIVYM*HF*NFKK

Frame 1

RSEGNGLGGAGMRS*ASRARRADGSTMQAAVAV
SVPFLLLCVLGTCPPARCGQAGDASLMELEKRK
ENRFVERQSIVPLRLIYRSGGEDESRHDALDTRV
RGDLGGPQLTHVDQASFQVDAFGTSFILDVVLN
HDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEE
NDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQV
NITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD
LIYKDQLKTRIVLVAMETWATDNKFAISENPLI
TLREFMKYRRDFIKEKSDAVHLFSGSQFESSRS
GAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSL
AHNIGIISDKRKLASGECKCEDTWSGCIMGDTG
YYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSK
LLDPPECGNGFIETGEECDCGTPAECVLEGAECC
KKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAV
NDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLN
IEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTN
IGNIPRLGELDGEITSTLVVQQGRTLNCSGGHV
KLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASF
NFSTCLSSKEGTICSGNGVCSNELKCVCNRHWI
GSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG
IIAGTILVLALILGITAWGYKNYREQRQLPQGDY
VKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGL
SHSWSERIPDTKHISDICENGRPRSNSWQGNLG
GNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSI
ASSRKYPYPMPPLPDEDKKVNRQSARLWETSI*
DQLFTCDTSKTVYFNFYRNPGSWNHCKSICSSD
NTKTL*DATEERKRSFTSGYHFLFVIGLGFN*P*
KELLKYYTITWNNKGTGMLMDNPHDR*YVEIFI
KLTHMTQM*QVS*GTIVDSELDVLRHILTVNSN
AICMKLLFIVFHI*GNNIP**K*ACRAKAYRIFL
QDFKALKGQYPIG*L*TCIFIFVLFFTFHIYIS
IQGQLYICNIFKILKK

Frame 2

GARETDSAAPA*GAERLGRGGLTAAPCRRQWLC
PCPSCCSVSWGPALRRAAARQETPH*WS*RRGR
KTASWSARASCHCASSTARAAKTKVGTTRSTRG
CGATSVARS*LMLTKQASRLMPLERHSFSMSC*I
MICCPLNT*RDTLNMEARLWKLKEESTVTTRAI
SEETLTHLLHCQHATDFMGCSMTGTTHISLSQK
KMTLLKRISIFIQFTNPDCLNFPWMIFHLNFSK*
TLLHQNLF*SQDQKGVNGSFVDILVM*KKKPNT
LN**L*MITLCLKNIGFPLYIPIPMRNLW*TWQ
I*YIKTNLRPG*YWLLWKPGRLTTSLPYLKIH*S
PYVSL*NTGGILSKRKVMQFTFFREVNLRVAGA
GQLILVGFARC*KEEA*MNLGKLI*WLLHLPSH
*PIILVLSQTKES*QVVNVNARTRGPGA*WETLA
IIFLKSSPSVILKSIMTS*IVEVVPAFSTNLLS
FLILLSVAMASLKLERSVIVEPRPNVSLKEQSV
VRNAP*LKTLNAVTVFAVKSASFSLWALCAEKQ*
MIVIFVKRAQEIQASVPLIFIKWMDIHVMVFRE
FALEEDAKPEIDNANTFGGKR*QHQTNIAMRN*
ILKGRRRVTVGKTKTHGYSATNGMCFVVTFCVPI
LAISQGLENSMVKSHLL*LCSKEEH*TAVVGML
SLKKM*ILAMWKMGHLVVPK*CA*NTGVFLWLL
STLVLA*AVKKALFAQEMEFAVMS*SVCVTDTG*
VLIATLTSLTMMMQRLVSLCLAMVLLAPIS**A
*LLAPF*CWPSY*E*LRGVIKTIENRDSYPREI
M*KSLEMVTLFIATFLPESAQTQHLVLRRGQMGS
LILGVKGFQTQNIFQTSVKMGDLEVTLGKVTWE
ATKRKSEAKDLDLGLIQLRLYLLPSLLLHQLGL
LPPAENTLTQCLHFLMRTRK*TDKVPGYGRHPFK
INCLHVIHRKLFTSTFIETQAHGITANLSALQT
IRRPSEMLQRRGSGVSHLVTIFFLSLA*DLTNH
EKNY*NITL*HGTIKVLVC*WIIRMTDNM*KYS*
S*LT*PKCSKFPKVQ*WIQNLTF*GTSSL*TVM
LYA*SFCLLFSIFKETTSHNRNEHAGLRHIGFF
CRTLKL*KANIP*ANFKHVFLFLFCFLLFIFILA
YKDNCIYVTFLKF*K

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