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Sequences

Sequence NM_001002838

CTCAGCTCCGGGCCGAGCGCGAGCTTGGGCTCGTACCCCGCTCCCCTCTCTCCGCCCGCTCTTTACCTACCGGCCGTAGCTGGCCCGGTGGGCTCGCGGG
GAGACGCTCGCGCGCGCAAGCGCACACGACGCGGAGCGGAGCTCGAGACATCGAGGAGAGGAGTAAGAAGCATCGGAGGAGGCGATCGAGGAGGAGGCGG
TGTGTGTGTATGTGTCTATTCTACGGTGTGGCTCGTCGTGGGGCGAGAGGAGGCTCGAGAGAGGGCGAGGGAGAAGCGAAAAGAGTAAGAGAGTCTTCCT
TTGCGAGAGCCTCTAATCTGGTTGCTATGGAAATACATGACCACGCAAAAGGAAGTCCATTCTGATAATTCTGATACCTGAGATGTAACTGGACTGAAGA
GTAGAAACAGGAAAAATTTTAGTGCCAACTTTAATTACAATGGCCACTGATTCAGGGGATCCAGCCAGCACAGAAGATTCTGAGAAACCTGATGGAATTT
CATTTGAAAACAGAGTTCCCCAGGTCGCTGCAACTTTGACAGTAGAAGCTAGACTAAAGGAGAAAAACAGTACCTTCTCTGCTTCTGGGGAAACTGTAGA
AAGGAAGAGATTTTTCCGAAAGAGTGTTGAAATGACGGAAGATGACAAAGTTGCCGAATCATCCCCCAAAGATGAGAGAATTAAGGCTGCAATGAATATT
CCAAGAGTAGATAAGCTTCCTTCAAATGTGTTGAGAGGTGGACAAGAAGTTAAATATGAACAGTGTTCAAAGTCAACCTCAGAAATCTCAAAAGATTGTT
TCAAGGAGAAAAATGAAAAGGAAATGGAAGAAGAAGCAGAAATGAAGGCTGTAGCTACTTCTCCTAGTGGCAGATTCCTGAAATTTGACATAGAACTAGG
AAGAGGAGCATTTAAAACAGTATATAAAGGACTGGACACTGAAACATGGGTTGAGGTTGCTTGGTGTGAGCTGCAGGACCGAAAGTTAACCAAAGCTGAG
CAGCAAAGATTCAAGGAAGAAGCAGAGATGTTGAAGGGTCTCCAGCACCCCAATATAGTTCGATTTTATGATTCCTGGGAATCTATATTAAAAGGAAAGA
AATGTATTGTATTAGTGACTGAACTAATGACATCTGGGACCTTAAAGACGTACTTAAAACGATTTAAAGTCATGAAACCAAAGGTCTTAAGGAGCTGGTG
CAGGCAAATTTTAAAGGGGTTGCAGTTCTTGCACACTAGGACTCCTCCTATTATTCACCGGGATCTGAAGTGTGACAATATTTTCATCACGGGACCCACT
GGATCTGTGAAGATTGGTGATCTAGGATTAGCCACCTTAATGCGTACCTCATTTGCTAAGAGTGTCATTGGAACTCCTGAGTTTATGGCTCCAGAGATGT
ATGAAGAACACTATGATGAATCCGTAGATGTTTATGCTTTTGGAATGTGTATGCTGGAAATGGCCACATCGGAGTATCCTTATTCTGAGTGTCAGAATGC
AGCTCAAATATACCGGAAAGTAACTAGTGGCATAAAACCAGCCAGCTTCAATAAAGTCACTGATCCTGAAGTCAAAGAAATCATTGAAGGATGTATTCGT
CAAAACAAATCTGAAAGGTTGTCTATCAGGGACCTATTAAACCATGCATTTTTTGCTGAGGATACAGGACTGAGGGTGGAGTTAGCAGAAGAAGATGATT
GCTCAAATTCATCCCTTGCTTTAAGACTCTGGGTTGAAGACCCTAAAAAATTGAAAGGCAAACACAAAGACAATGAAGCTATTGAATTTAGTTTCAACTT
AGAAACAGATACACCTGAGGAAGTAGCATATGAAATGGTCAAGTCTGGGTTCTTCCATGAAAGTGATTCCAAAGCTGTTGCTAAATCCATTAGAGACCGG
GTGACGCCAATAAAGAAGACAAGAGAGAAGAAGCCTGCTGGCTGTTTGGAAGAACGCAGGGATTCTCAGTGCAAGTCTATGGGGAATGTATTCCCTCAGC
CCCAGAATACAACTTTACCCCTTGCTCCCGCTCAGCAAACTGGGGCTGAATGTGAAGAAACTGAAGTTGATCAACATGTTAGACAACAGCTTCTACAAAG
AAAACCACAGCAGCACTGCTCCTCTGTTACAGGTGACAATTTGTCTGAGGCAGGAGCTGCATCAGTTATACATTCAGATACTTCAAGTCAGCCCAGTGTA
GCCTATTCCTCAAATCAAACGATGGGCTCTCAAATGGTTTCTAATATCCCGCAGGCTGAAGTAAATGTTCCAGGGCAAATTTATTCATCTCAGCAACTAG
TAGGACATTACCAGCAAGTTTCAGGGTTACAGAAGCATTCAAAGCTGACTCAGCCGCAGATTTTGCCTTTGGTTCAAGGTCAGTCCACTGTTTTACCTGT
ACATGTCCTTGGACCGACAGTTGTTTCACAACCCCAGGTTTCCCCATTAACTGTTCAGAAGGTCCCACAGATAAAGCCTGTATCCCAACCAGTTGGAGCT
GAACAACAAGCAGCTCTTCTAAAACCAGATTTAGTTCGAAGCTTGAATCAAGATGTGGCAACTACGAAGGAAAACGTCAGTAGCCCTGATAACCCAAGTG
GAAATGGCAAACAGGATCGGATCAAACAGAGAAGAGCTTCCTGTCCCCGACCAGAGAAGGGGACTAAATTTCAGCTTACCGTCCTTCAGGTATCAACCTC
TGGAGATAACATGGTAGAGTGTCAGCTGGAGACACACAACAACAAGATGGTCACCTTCAAGTTTGATGTTGATGGTGATGCGCCAGAGGATATTGCAGAC
TATATGGTTGAAGATAACTTTGTGCTGGAAAGTGAGAAAGAAAAATTTGTAGAAGAATTGAGAGCTATTGTAGGTCAAGCCCAGGAGATCCTTCATGTCC
ACTTTGCCACAGAAAGAGCCACTGGAGTTGATTCTATTACTGTGGACTCCAACAGTAGCCAGACAGGGTCATCTGAACAAGTACAGATAAATTCTACATC
TACTCAAACCAGCAATGAATCTGCTCCTCAGTCATCCCCAGTTGGTCGGTGGCGATTCTGTATCAATCAGACGATAAGAAACCGTGAGACTCAGTCTCCT
CCTTCTCTTCAGCATTCCATGTCTGCGGTTCCTGGCCGACATCCACTTCCTAGTCCAAAAAACACAAGTAATAAGGAAATATCACGGGACACATTGCTCA
CTATAGAAAATAATCCATGCCACCGTGCACTTTTCACCTCCAAATCAGAACACAAGGATGTGGTTGATGGTAAGATTTCTGAATGTGCTAGTGTAGAAAC
CAAGCAGCCAGCTATACTTTATCAAGTGGAAGATAACAGGCAGATAATGGCACCAGTTACTAATAGTTCCAGTTACTCTACTACTTCAGTTCGTGCAGTT
CCAGCTGAATGTGAGGGACTCACCAAACAAGCAAGCATATTCATACCTGTGTATCCATGTCACCAAACTGCCAGTCAGGCTGATGCACTTATGTCCCATC
CTGGCGAATCAACTCAGACTTCTGGTAACTCTCTTACAACTCTGGCATTTGATCAAAAGCCTCAAACCTTATCAGTACAGCAGCCAGCTATGGATGCAGA
GTTTATTTCTCAAGAAGGAGAAACTACAGTGAACACTGAAGCAAGTTCTCCTAAGACAGTCATTCCCACTCAGACCCCTGGCCTTGAACCAACTACCCTT
CAACCCACTACTGTCCTGGAATCAGATGGAGAAAGACCTCCAAAACTGGAGTTTGCAGACAACCGAATTAAAACTCTGGATGAAAAATTAAGAAACTTGC
TCTATCAGGAGCACAGCATCTCTAGCATCTATCCCGAGAGTCAGAAGGATACCCAAAGCATAGACTCTCCATTTTCTTCCTCTGCTGAAGATACCCTCTC
CTGTCCAGTGACAGAAGTCATAGCCATCAGTCACTGTGGAATTAAAGATAGCCCTGTACAATCCCCTAATTTCCAACAGACAGGCTCTAAGCTTCTGTCC
AATGTGGCTGCAAGTCAGCCTGCTAATATATCAGTGTTCAAAAGGGACCTGAATGTGATAACTTCTGTACCCAGCGAATTGTGTTTACATGAGATGTCCT
CAGATGCTTCACTTCCAGGGGATCCAGAGGCCTATCCTGCTGCTGTGTCAAGCGGTGGAGCCATTCATCTGCAGACAGGAGTGGAAACAGAAGAGATGAG
ATCAGCAATTGCTCCTGATCCCATTCCTCTGACACGGGAGTCCACAGCTGATACTAGGGCTTTGAATAGATGTAAAGCGATGAGTGGATCATTTCAGCGG
GGTCGGTTCCAGGTGATTACAATTCCTCAGCAGCAGTCAGCAAAAATGACATCTTTTGGAATAGAACACATATCAGTGTTCAGTGAGACAAACCATTCTA
GTGAAGAAGCCTTTATTAAAACAGCAAAGTCTCAGTTGGTAGAAATAGAACCTGCCACACAAAATCCAAAAACTTCGTTTTCTTATGAGAAGTTACAAGC
TCTTCAGGAAACCTGTAAAGAAAATAAAGGAGTTCCCAAACAAGGTGACAACTTCTTATCTTTCAGCGCAGCTTGTGAGACTGATGTATCTTCAGTGACC
CCAGAAAAGGAATTTGAAGAAACTTCAGCCACAGGAAGTAGCATGCAGTCTGGATCTGAACTGTTGCTTAAAGAGAGAGAGATATTGACTGCTGGGAAAC
AGCCTAGCTCTGATAGTGAATTTTCAGCCAGTCTTGCTGGCAGTGGAAAGTCAGTGGCAAAGACTGGTCCAGAGAGTAATCAGTGCTTACCACACCACGA
AGAACAAGCTTATGCTCAAACACAGAGTTCACTCTTCTATTCGCCATCTTCCCCAATGAGCAGTGATGATGAATCAGAAATAGAGGATGAGGACTTGAAG
GTGGAGCTTCAAAGATTACGAGAAAAACACATTCAGGAGGTGGTAAATCTTCAAACCCAGCAGAATAAGGAGCTGCAGGAGCTCTATGAACGCCTTCGGT
CAATTAAAGATAGCAAAACCCAATCTACTGAGATTCCTTTGCCACCTGCATCACCACGTCGACCAAGATCTTTCAAAAGCAAACTTCGAAGCCGCCCCCA
GTCCTTGACACATGTGGACAATGGCATAGTTGCTACAGATCCACTGTGTGTGGAGAGTAATGCAGCATCATGCCAACAGTCTCCAGCCAGTAAAAAAGGG
ATGTTCACAGATGACTTACACAAGCTGGTGGATGACTGGACAAAGGAAGCAGTAGGAAATTCTCTTATTAAGCCAAGTTTAAACCAACTTAAACAAAGTC
AACACAAACTAGAGACAGAAAACTGGAATAAAGTATCTGAAAATACTCCGTCTACTATGGGCTACACATCAACATGGATTTCTTCTCTGTCCCAAATCCG
TGGAGCTGTCCCAACTTCCTTGCCACAAGGACTCTCACTCCCTTCATTTCCTGGGCCATTATCATCATATGGAATGCCTCACGTTTGTCAGTATAATGCT
GTGGCGGGGGCGGGGTATCCAGTACAGTGGGTAGGAATTTCAGGAACAACACAACAATCTGTAGTAATTCCCGCCCAATCTGGGGGACCATTCCAGCCAG
GGATGAATATGCAGGCATTTCCAACTTCATCAGTGCAGAATCCTGCCACAATCCCTCCTGGTCCTAAATGAATCAGAGTAGATGGTGATAAAAAGGGAGG
TTTTTTCAGAATTATTTTCAGGACACCCAAGATATTAAAGTTTCTTCCTCTTGGGTTCTGTCATATTTTCCCTCATTTGAGTTTACTTTAGACTATATAT
TTTTTGTTCCAGTGTGGTATTTGATACAGCTCATCATTCTGTAGAAATGTGCAGTTTGCAGATAGAACACTGCACACAGAAATGTTTTTTCACTTCAAAT
TCTATCCTCTTTGATACTTGATTTTTTAAAAATACTGTTCAGAATGCTTTAATAAGCTCAGCTTGAGCATTACCATTTCCAGGACACTTTCCATGAATTG
TTGAGAAGCTCCCCATCCCCCGCCTTTTTTTTTTTTTTTTTTAACTGCTGCTATCTGCAGCTGGATACTCTTCTTTAAAAATGTTTAAAAATTATTTAGA
TTGATTCTCCCCAAATGTGGATGAACTGAGACCCTCCATCAGCCAGAGTCTTATGGGATCTTCACTTCACATGTTTGTCTTAGGTTTACCTTTCACAGAA
GGCAGGGTAACTTGCTGCAGGAAACGTTTTGGTGTATAAAATTAGAATCACTTTTTTTTTTTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGTTGGA
GTGCAGTGGTGTGATCTTGGCTCACTGCTGCAACCTCCCCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCC
AGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGGATGGGGTTTCACTATGTTGGCCAGACTGGTCTCAAACTCCTAACCTTGTGATCCGCCCTC
CTTAGCCCCCCCAAAAAATTACAATAATTTTGTCAACCAATACAGAACATGAGCCCTTTTTAAATGTGATTTCCCGTCATCACAGCAGTAGGATGAAGCC
TTGTTTTGGGTGAGACAGAGGGAAAGGGAAAAAACAGAATTGTAACAGTTCCTTGATTCTGCAGATACTGCTGCTGTTTTACGATTTCAGTAATAATTCA
AAGCAGCTGTCTCCTTGTTTCTCACATGCATACTACATTGGTTTTGAGCATCTGAGAGGCATTGGTTTGTCTTGCATTCTTTTGCAAGGCATATATTGCA
GCTGATATGAATCTCGTTTGGGGGGAATCCTTGTATTCCTAACAAGGGGGATTAAAGCTACACCTCAATCCATTCTTCTGAAGTGAAATTTACTTGACAC
AGTAGGTTTCGAGACTTACATATGAAACACTGGCTTTACAGGGTTCTCAGAGATGTGGGGTATACACTGTCCTGCAGTGAGATAGTAGACCCTAGAAGGA
TACTATTTAAGTTGTCCTTAGCTCTTTTTAATTACAATTTTTAGTTGTTAGAATTTCTTTTTAGTATCTATAGTATCTTAGATGATTTTAGATCTTAAAT
GAGTTTGGCAGCCTCTTTAGAATCTGAGAGAGATCACTGTCAAGTTGCACTTTACTGGGTTTTATCCAGTTTTAGGAGGAGGGGAGGCAATGTCAAAATG
TACACCTTTGGTTTTTAAGAAGGTTAACTATAATAATGTTAAAGGCTAGTCACAGGGTTACCTAATGCTCAGTCTGTGAAACCTAAATAGAATTCTTAAA
ATGTTATTTACCAACTAAGTATTCATGTTCAAATTACTTACCTTCCACTCTGAAGACTTTAAGGTCATTTCTAATACACATTTACCTAATTAGGAGTTCT
GTCTACTAGTAAACATTCCAAATTGCTACCCAACATTACTGTTAACAGATTTTCCTCCGTATTCTTCTAAAAATTATACCCCATGGGCTTGCCAGGTAAT
GACGAAAACTTAATGGGTGTACTTTTTTTTTTTTTTGCACAGTCTACTTTGTGACATTAAGTACCTCTTTTCC
  • refseq_WNK3.F3 (forward primer)
  • refseq_WNK3.R3 (reverse primer)
  • Single exon skipping

Frame 0

LSSGPSASLGSYPAPLSPPALYLPAVAGPVGSR
GDARARKRTRRGAELETSRRGVRSIGGGDRGGGG
VCVCVYSTVWLVVGREEARERAREKRKE*ESLP
LREPLIWLLWKYMTTQKEVHSDNSDT*DVTGLK
SRNRKNFSANFNYNGH*FRGSSQHRRF*ET*WNF
I*KQSSPGRCNFDSRS*TKGEKQYLLCFWGNCR
KEEIFPKEC*NDGR*QSCRIIPQR*EN*GCNEY
SKSR*ASFKCVERWTRS*I*TVFKVNLRNLKRLF
QGEK*KGNGRRSRNEGCSYFS*WQIPEI*HRTR
KRSI*NSI*RTGH*NMG*GCLV*AAGPKVNQS*
AAKIQGRSRDVEGSPAPQYSSIL*FLGIYIKRKE
MYCISD*TNDIWDLKDVLKTI*SHETKGLKELV
QANFKGVAVLAH*DSSYYSPGSEV*QYFHHGTH
WICEDW*SRISHLNAYLIC*ECHWNS*VYGSRDV
*RTL**IRRCLCFWNVYAGNGHIGVSLF*VSEC
SSNIPESN*WHKTSQLQ*SH*S*SQRNH*RMYS
SKQI*KVVYQGPIKPCIFC*GYRTEGGVSRRR*L
LKFIPCFKTLG*RP*KIERQTQRQ*SY*I*FQL
RNRYT*GSSI*NGQVWVLP*K*FQSCC*IH*RP
GDANKEDKREEACWLFGRTQGFSVQVYGECIPSA
PEYNFTPCSRSANWG*M*RN*S*STC*TTASTK
KTTAALLLCYR*QFV*GRSCISYTFRYFKSAQC
SLFLKSNDGLSNGF*YPAG*SKCSRANLFISATS
RTLPASFRVTEAFKADSAADFAFGSRSVHCFTC
TCPWTDSCFTTPGFPINCSEGPTDKACIPTSWS
*TTSSSSKTRFSSKLESRCGNYEGKRQ*P**PKW
KWQTGSDQTEKSFLSPTREGD*ISAYRPSGINL
WR*HGRVSAGDTQQQDGHLQV*C*W*CARGYCR
LYG*R*LCAGK*ERKICRRIESYCRSSPGDPSCP
LCHRKSHWS*FYYCGLQQ*PDRVI*TSTDKFYI
YSNQQ*ICSSVIPSWSVAILYQSDDKKP*DSVS
SFSSAFHVCGSWPTSTS*SKKHK**GNITGHIAH
YRK*SMPPCTFHLQIRTQGCG*W*DF*MC*CRN
QAASYTLSSGR*QADNGTSY**FQLLYYFSSCS
SS*M*GTHQTSKHIHTCVSMSPNCQSG*CTYVPS
WRINSDFW*LSYNSGI*SKASNLISTAASYGCR
VYFSRRRNYSEH*SKFS*DSHSHSDPWP*TNYP
STHYCPGIRWRKTSKTGVCRQPN*NSG*KIKKLA
LSGAQHL*HLSRESEGYPKHRLSIFFLC*RYPL
LSSDRSHSHQSLWN*R*PCTIP*FPTDRL*ASV
QCGCKSAC*YISVQKGPECDNFCTQRIVFT*DVL
RCFTSRGSRGLSCCCVKRWSHSSADRSGNRRDE
ISNCS*SHSSDTGVHS*Y*GFE*M*SDEWIISA
GSVPGDYNSSAAVSKNDIFWNRTHISVQ*DKPF*
*RSLY*NSKVSVGRNRTCHTKSKNFVFL*EVTS
SSGNL*RK*RSSQTR*QLLIFQRSL*D*CIFSD
PRKGI*RNFSHRK*HAVWI*TVA*RERDIDCWET
A*L***IFSQSCWQWKVSGKDWSRE*SVLTTPR
RTSLCSNTEFTLLFAIFPNEQ***IRNRG*GLE
GGASKITRKTHSGGGKSSNPAE*GAAGAL*TPSV
N*R*QNPIY*DSFATCITTSTKIFQKQTSKPPP
VLDTCGQWHSCYRSTVCGE*CSIMPTVSSQ*KR
DVHR*LTQAGG*LDKGSSRKFSY*AKFKPT*TKS
TQTRDRKLE*SI*KYSVYYGLHINMDFFSVPNP
WSCPNFLATRTLTPFISWAIIIIWNASRLSV*C
CGGGGVSSTVGRNFRNNTTICSNSRPIWGTIPAR
DEYAGISNFISAESCHNPSWS*MNQSRW**KGR
FFQNYFQDTQDIKVSSSWVLSYFPSFEFTLDYI
FFVPVWYLIQLIIL*KCAVCR*NTAHRNVFSLQI
LSSLILDFLKILFRML**AQLEHYHFQDTFHEL
LRSSPSPAFFFFFFNCCYLQLDTLL*KCLKII*
IDSPQMWMN*DPPSARVLWDLHFTCLS*VYLSQK
AG*LAAGNVLVYKIRITFFFFFEMESLSVTQVG
VQWCDLGSLLQPPPPGFKRFSCLSLLSSWDYRR
QPPCLANFCIFSRGWGFTMLARLVSNS*PCDPPS
LAPPKNYNNFVNQYRT*ALFKCDFPSSQQ*DEA
LFWVRQREREKTEL*QFLDSADTAAVLRFQ**F
KAAVSLFLTCILHWF*ASERHWFVLHSFARHILQ
LI*ISFGGNPCIPNKGD*SYTSIHSSEVKFT*H
SRFRDLHMKHWLYRVLRDVGYTLSCSEIVDPRR
ILFKLSLALFNYNF*LLEFLFSIYSILDDFRS*M
SLAASLESERDHCQVALYWVLSSFRRRGGNVKM
YTFGF*EG*L**C*RLVTGLPNAQSVKPK*NS*
NVIYQLSIHVQITYLPL*RL*GHF*YTFT*LGVL
STSKHSKLLPNITVNRFSSVFF*KLYPMGLPGN
DENLMGVLFFFFAQSTL*H*VPLF

Frame 1

SAPGRARAWARTPLPSLRPLFTYRP*LARWARG
ETLARASAHDAERSSRHRGEE*EASEEAIEEEA
VCVYVSILRCGSSWGERRLERGRGRSEKSKRVFL
CESL*SGCYGNT*PRKRKSILIILIPEM*LD*R
VETGKILVPTLITMATDSGDPASTEDSEKPDGI
SFENRVPQVAATLTVEARLKEKNSTFSASGETVE
RKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI
PRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELG
RGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE
QQRFKEEAEMLKGLQHPNIVRFYDSWESILKGK
KCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWC
RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT
GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM
YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNA
AQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR
QNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNL
ETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDR
VTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQ
PQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQR
KPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSV
AYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQL
VGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPV
HVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGA
EQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTS
GDNMVECQLETHNNKMVTFKFDVDGDAPEDIAD
YMVEDNFVLESEKEKFVEELRAIVGQAQEILHV
HFATERATGVDSITVDSNSSQTGSSEQVQINSTS
TQTSNESAPQSSPVGRWRFCINQTIRNRETQSP
PSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLL
TIENNPCHRALFTSKSEHKDVVDGKISECASVET
KQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAV
PAECEGLTKQASIFIPVYPCHQTASQADALMSH
PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAE
FISQEGETTVNTEASSPKTVIPTQTPGLEPTTL
QPTTVLESDGERPPKLEFADNRIKTLDEKLRNL
LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLS
CPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLS
NVAASQPANISVFKRDLNVITSVPSELCLHEMS
SDASLPGDPEAYPAAVSSGGAIHLQTGVETEEMR
SAIAPDPIPLTRESTADTRALNRCKAMSGSFQR
GRFQVITIPQQQSAKMTSFGIEHISVFSETNHS
SEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQA
LQETCKENKGVPKQGDNFLSFSAACETDVSSVT
PEKEFEETSATGSSMQSGSELLLKEREILTAGK
QPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHE
EQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLK
VELQRLREKHIQEVVNLQTQQNKELQELYERLR
SIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQ
SLTHVDNGIVATDPLCVESNAASCQQSPASKKG
MFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQS
QHKLETENWNKVSENTPSTMGYTSTWISSLSQIR
GAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNA
VAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQP
GMNMQAFPTSSVQNPATIPPGPK*IRVDGDKKGG
FFRIIFRTPKILKFLPLGFCHIFPHLSLL*TIY
FLFQCGI*YSSSFCRNVQFADRTLHTEMFFHFK
FYPL*YLIF*KYCSECFNKLSLSITISRTLSMNC
*EAPHPPPFFFFFLTAAICSWILFFKNV*KLFR
LILPKCG*TETLHQPESYGIFTSHVCLRFTFHR
RQGNLLQETFWCIKLESLFFFFLRWSLSLSPRLE
CSGVILAHCCNLPLLGSSDSPASAS*VAGTTGA
SHHAWLIFVFLVEDGVSLCWPDWSQTPNLVIRP
P*PPQKITIILSTNTEHEPFLNVISRHHSSRMKP
CFG*DRGKGKKQNCNSSLILQILLLFYDFSNNS
KQLSPCFSHAYYIGFEHLRGIGLSCILLQGIYC
S*YESRLGGILVFLTRGIKATPQSILLK*NLLDT
VGFETYI*NTGFTGFSEMWGIHCPAVR**TLEG
YYLSCP*LFLITIFSC*NFFLVSIVS*MILDLK
*VWQPL*NLREITVKLHFTGFYPVLGGGEAMSKC
TPLVFKKVNYNNVKG*SQGYLMLSL*NLNRILK
MLFTN*VFMFKLLTFHSEDFKVISNTHLPN*EF
CLLVNIPNCYPTLLLTDFPPYSSKNYTPWACQVM
TKT*WVYFFFFLHSLLCDIKYLFS

Frame 2

QLRAERELGLVPRSPLSARSLPTGRSWPGGLAG
RRSRAQAHTTRSGARDIEERSKKHRRRRSRRRR
CVCMCLFYGVARRGARGGSREGEGEAKRVRESS
FARASNLVAMEIHDHAKGSPF**F*YLRCNWTEE
*KQEKF*CQL*LQWPLIQGIQPAQKILRNLMEF
HLKTEFPRSLQL*Q*KLD*RRKTVPSLLLGKL*
KGRDFSERVLK*RKMTKLPNHPPKMRELRLQ*IF
QE*ISFLQMC*EVDKKLNMNSVQSQPQKSQKIV
SRRKMKRKWKKKQK*RL*LLLLVADS*NLT*N*
EEEHLKQYIKDWTLKHGLRLLGVSCRTES*PKLS
SKDSRKKQRC*RVSSTPI*FDFMIPGNLY*KER
NVLY**LN**HLGP*RRT*NDLKS*NQRS*GAG
AGKF*RGCSSCTLGLLLLFTGI*SVTIFSSRDPL
DL*RLVI*D*PP*CVPHLLRVSLELLSLWLQRC
MKNTMMNP*MFMLLECVCWKWPHRSILILSVRM
QLKYTGK*LVA*NQPASIKSLILKSKKSLKDVFV
KTNLKGCLSGTY*TMHFLLRIQD*GWS*QKKMI
AQIHPLL*DSGLKTLKN*KANTKTMKLLNLVST
*KQIHLRK*HMKWSSLGSSMKVIPKLLLNPLETG
*RQ*RRQERRSLLAVWKNAGILSASLWGMYSLS
PRIQLYPLLPLSKLGLNVKKLKLINMLDNSFYK
ENHSSTAPLLQVTICLRQELHQLYIQILQVSPV*
PIPQIKRWALKWFLISRRLK*MFQGKFIHLSN*
*DITSKFQGYRSIQS*LSRRFCLWFKVSPLFYL
YMSLDRQLFHNPRFPH*LFRRSHR*SLYPNQLEL
NNKQLF*NQI*FEA*IKMWQLRRKTSVALITQV
EMANRIGSNREELPVPDQRRGLNFSLPSFRYQP
LEITW*SVSWRHTTTRWSPSSLMLMVMRQRILQT
IWLKITLCWKVRKKNL*KN*ELL*VKPRRSFMS
TLPQKEPLELILLLWTPTVARQGHLNKYR*ILH
LLKPAMNLLLSHPQLVGGDSVSIRR*ETVRLSLL
LLFSIPCLRFLADIHFLVQKTQVIRKYHGTHCS
L*KIIHATVHFSPPNQNTRMWLMVRFLNVLV*K
PSSQLYFIKWKITGR*WHQLLIVPVTLLLQFVQF
QLNVRDSPNKQAYSYLCIHVTKLPVRLMHLCPI
LANQLRLLVTLLQLWHLIKSLKPYQYSSQLWMQ
SLFLKKEKLQ*TLKQVLLRQSFPLRPLALNQLPF
NPLLSWNQMEKDLQNWSLQTTELKLWMKN*ETC
SIRSTASLASIPRVRRIPKA*TLHFLPLLKIPS
PVQ*QKS*PSVTVELKIALYNPLISNRQALSFCP
MWLQVSLLIYQCSKGT*M**LLYPANCVYMRCP
QMLHFQGIQRPILLLCQAVEPFICRQEWKQKR*
DQQLLLIPFL*HGSPQLILGL*IDVKR*VDHFSG
VGSR*LQFLSSSQQK*HLLE*NTYQCSVRQTIL
VKKPLLKQQSLSW*K*NLPHKIQKLRFLMRSYK
LFRKPVKKIKEFPNKVTTSYLSAQLVRLMYLQ*P
QKRNLKKLQPQEVACSLDLNCCLKRERY*LLGN
SLALIVNFQPVLLAVESQWQRLVQRVISAYHTT
KNKLMLKHRVHSSIRHLPQ*AVMMNQK*RMRT*R
WSFKDYEKNTFRRW*IFKPSRIRSCRSSMNAFG
QLKIAKPNLLRFLCHLHHHVDQDLSKANFEAAP
SP*HMWTMA*LLQIHCVWRVMQHHANSLQPVKKG
CSQMTYTSWWMTGQRKQ*EILLLSQV*TNLNKV
NTN*RQKTGIKYLKILRLLWATHQHGFLLCPKS
VELSQLPCHKDSHSLHFLGHYHHMECLTFVSIML
WRGRGIQYSG*EFQEQHNNL**FPPNLGDHSSQ
G*ICRHFQLHQCRILPQSLLVLNESE*MVIKRE
VFSELFSGHPRY*SFFLLGSVIFSLI*VYFRLYI
FCSSVVFDTAHHSVEMCSLQIEHCTQKCFFTSN
SILFDT*FFKNTVQNALISSA*ALPFPGHFP*I
VEKLPIPRLFFFFF*LLLSAAGYSSLKMFKNYLD
*FSPNVDELRPSISQSLMGSSLHMFVLGLPFTE
GRVTCCRKRFGV*N*NHFFFFF*DGVSLCHPGW
SAVV*SWLTAATSPSWVQAILLPQPPE*LGLQAP
ATMPG*FLYF**RMGFHYVGQTGLKLLTL*SAL
LSPPKKLQ*FCQPIQNMSPF*M*FPVITAVG*S
LVLGETEGKGKNRIVTVP*FCRYCCCFTISVIIQ
SSCLLVSHMHTTLVLSI*EALVCLAFFCKAYIA
ADMNLVWGESLYS*QGGLKLHLNPFF*SEIYLT
Q*VSRLTYETLALQGSQRCGVYTVLQ*DSRP*KD
TI*VVLSSF*LQFLVVRISF*YL*YLR*F*ILN
EFGSLFRI*ERSLSSCTLLGFIQF*EEGRQCQN
VHLWFLRRLTIIMLKASHRVT*CSVCET*IEFLK
CYLPTKYSCSNYLPSTLKTLRSFLIHIYLIRSS
VY**TFQIATQHYC*QIFLRILLKIIPHGLAR*
*RKLNGCTFFFFCTVYFVTLSTSF

Sequence NM_020922

CTCAGCTCCGGGCCGAGCGCGAGCTTGGGCTCGTACCCCGCTCCCCTCTCTCCGCCCGCTCTTTACCTACCGGCCGTAGCTGGCCCGGTGGGCTCGCGGG
GAGACGCTCGCGCGCGCAAGCGCACACGACGCGGAGCGGAGCTCGAGACATCGAGGAGAGGAGTAAGAAGCATCGGAGGAGGCGATCGAGGAGGAGGCGG
TGTGTGTGTATGTGTCTATTCTACGGTGTGGCTCGTCGTGGGGCGAGAGGAGGCTCGAGAGAGGGCGAGGGAGAAGCGAAAAGAGTAAGAGAGTCTTCCT
TTGCGAGAGCCTCTAATCTGGTTGCTATGGAAATACATGACCACGCAAAAGGAAGTCCATTCTGATAATTCTGATACCTGAGATGTAACTGGACTGAAGA
GTAGAAACAGGAAAAATTTTAGTGCCAACTTTAATTACAATGGCCACTGATTCAGGGGATCCAGCCAGCACAGAAGATTCTGAGAAACCTGATGGAATTT
CATTTGAAAACAGAGTTCCCCAGGTCGCTGCAACTTTGACAGTAGAAGCTAGACTAAAGGAGAAAAACAGTACCTTCTCTGCTTCTGGGGAAACTGTAGA
AAGGAAGAGATTTTTCCGAAAGAGTGTTGAAATGACGGAAGATGACAAAGTTGCCGAATCATCCCCCAAAGATGAGAGAATTAAGGCTGCAATGAATATT
CCAAGAGTAGATAAGCTTCCTTCAAATGTGTTGAGAGGTGGACAAGAAGTTAAATATGAACAGTGTTCAAAGTCAACCTCAGAAATCTCAAAAGATTGTT
TCAAGGAGAAAAATGAAAAGGAAATGGAAGAAGAAGCAGAAATGAAGGCTGTAGCTACTTCTCCTAGTGGCAGATTCCTGAAATTTGACATAGAACTAGG
AAGAGGAGCATTTAAAACAGTATATAAAGGACTGGACACTGAAACATGGGTTGAGGTTGCTTGGTGTGAGCTGCAGGACCGAAAGTTAACCAAAGCTGAG
CAGCAAAGATTCAAGGAAGAAGCAGAGATGTTGAAGGGTCTCCAGCACCCCAATATAGTTCGATTTTATGATTCCTGGGAATCTATATTAAAAGGAAAGA
AATGTATTGTATTAGTGACTGAACTAATGACATCTGGGACCTTAAAGACGTACTTAAAACGATTTAAAGTCATGAAACCAAAGGTCTTAAGGAGCTGGTG
CAGGCAAATTTTAAAGGGGTTGCAGTTCTTGCACACTAGGACTCCTCCTATTATTCACCGGGATCTGAAGTGTGACAATATTTTCATCACGGGACCCACT
GGATCTGTGAAGATTGGTGATCTAGGATTAGCCACCTTAATGCGTACCTCATTTGCTAAGAGTGTCATTGGAACTCCTGAGTTTATGGCTCCAGAGATGT
ATGAAGAACACTATGATGAATCCGTAGATGTTTATGCTTTTGGAATGTGTATGCTGGAAATGGCCACATCGGAGTATCCTTATTCTGAGTGTCAGAATGC
AGCTCAAATATACCGGAAAGTAACTAGTGGCATAAAACCAGCCAGCTTCAATAAAGTCACTGATCCTGAAGTCAAAGAAATCATTGAAGGATGTATTCGT
CAAAACAAATCTGAAAGGTTGTCTATCAGGGACCTATTAAACCATGCATTTTTTGCTGAGGATACAGGACTGAGGGTGGAGTTAGCAGAAGAAGATGATT
GCTCAAATTCATCCCTTGCTTTAAGACTCTGGGTTGAAGACCCTAAAAAATTGAAAGGCAAACACAAAGACAATGAAGCTATTGAATTTAGTTTCAACTT
AGAAACAGATACACCTGAGGAAGTAGCATATGAAATGGTCAAGTCTGGGTTCTTCCATGAAAGTGATTCCAAAGCTGTTGCTAAATCCATTAGAGACCGG
GTGACGCCAATAAAGAAGACAAGAGAGAAGAAGCCTGCTGGCTGTTTGGAAGAACGCAGGGATTCTCAGTGCAAGTCTATGGGGAATGTATTCCCTCAGC
CCCAGAATACAACTTTACCCCTTGCTCCCGCTCAGCAAACTGGGGCTGAATGTGAAGAAACTGAAGTTGATCAACATGTTAGACAACAGCTTCTACAAAG
AAAACCACAGCAGCACTGCTCCTCTGTTACAGGTGACAATTTGTCTGAGGCAGGAGCTGCATCAGTTATACATTCAGATACTTCAAGTCAGCCCAGTGTA
GCCTATTCCTCAAATCAAACGATGGGCTCTCAAATGGTTTCTAATATCCCGCAGGCTGAAGTAAATGTTCCAGGGCAAATTTATTCATCTCAGCAACTAG
TAGGACATTACCAGCAAGTTTCAGGGTTACAGAAGCATTCAAAGCTGACTCAGCCGCAGATTTTGCCTTTGGTTCAAGGTCAGTCCACTGTTTTACCTGT
ACATGTCCTTGGACCGACAGTTGTTTCACAACCCCAGGTTTCCCCATTAACTGTTCAGAAGGTCCCACAGATAAAGCCTGTATCCCAACCAGTTGGAGCT
GAACAACAAGCAGCTCTTCTAAAACCAGATTTAGTTCGAAGCTTGAATCAAGATGTGGCAACTACGAAGGAAAACGTCAGTAGCCCTGATAACCCAAGTG
GAAATGGCAAACAGGATCGGATCAAACAGAGAAGAGCTTCCTGTCCCCGACCAGAGAAGGGGACTAAATTTCAGCTTACCGTCCTTCAGGTATCAACCTC
TGGAGATAACATGGTAGAGTGTCAGCTGGAGACACACAACAACAAGATGGTCACCTTCAAGTTTGATGTTGATGGTGATGCGCCAGAGGATATTGCAGAC
TATATGGTTGAAGATAACTTTGTGCTGGAAAGTGAGAAAGAAAAATTTGTAGAAGAATTGAGAGCTATTGTAGGTCAAGCCCAGGAGATCCTTCATGTCC
ACTTTGCCACAGAAAGAGCCACTGGAGTTGATTCTATTACTGTGGACTCCAACAGTAGCCAGACAGGGTCATCTGAACAAGTACAGATAAATTCTACATC
TACTCAAACCAGCAATGAATCTGCTCCTCAGTCATCCCCAGTTGGTCGGTGGCGATTCTGTATCAATCAGACGATAAGAAACCGTGAGACTCAGTCTCCT
CCTTCTCTTCAGCATTCCATGTCTGCGGTTCCTGGCCGACATCCACTTCCTAGTCCAAAAAACACAAGTAATAAGGAAATATCACGGGACACATTGCTCA
CTATAGAAAATAATCCATGCCACCGTGCACTTTTCACCTCCAAATCAGAACACAAGGATGTGGTTGATGGTAAGATTTCTGAATGTGCTAGTGTAGAAAC
CAAGCAGCCAGCTATACTTTATCAAGTGGAAGATAACAGGCAGATAATGGCACCAGTTACTAATAGTTCCAGTTACTCTACTACTTCAGTTCGTGCAGTT
CCAGCTGAATGTGAGGGACTCACCAAACAAGCAAGCATATTCATACCTGTGTATCCATGTCACCAAACTGCCAGTCAGGCTGATGCACTTATGTCCCATC
CTGGCGAATCAACTCAGACTTCTGGTAACTCTCTTACAACTCTGGCATTTGATCAAAAGCCTCAAACCTTATCAGTACAGCAGCCAGCTATGGATGCAGA
GTTTATTTCTCAAGAAGGAGAAACTACAGTGAACACTGAAGCAAGTTCTCCTAAGACAGTCATTCCCACTCAGACCCCTGGCCTTGAACCAACTACCCTT
CAACCCACTACTGTCCTGGAATCAGATGGAGAAAGACCTCCAAAACTGGAGTTTGCAGACAACCGAATTAAAACTCTGGATGAAAAATTAAGAAACTTGC
TCTATCAGGAGCACAGCATCTCTAGCATCTATCCCGAGAGTCAGAAGGATACCCAAAGCATAGACTCTCCATTTTCTTCCTCTGCTGAAGATACCCTCTC
CTGTCCAGTGACAGAAGTCATAGCCATCAGTCACTGTGGAATTAAAGATAGCCCTGTACAATCCCCTAATTTCCAACAGACAGGCTCTAAGCTTCTGTCC
AATGTGGCTGCAAGTCAGCCTGCTAATATATCAGTGTTCAAAAGGGACCTGAATGTGATAACTTCTGTACCCAGCGAATTGTGTTTACATGAGATGTCCT
CAGATGCTTCACTTCCAGGGGATCCAGAGGCCTATCCTGCTGCTGTGTCAAGCGGTGGAGCCATTCATCTGCAGACAGGAGGTGGATATTTTGGCCTAAG
CTTTACTTGTCCTAGTCTCAAAAATCCTATTAGCAAGAAATCCTGGACTCGCAAATTAAAAAGCTGGGCATACAGGCTACGGCAGTCAACCAGCTTTTTC
AAGAGATCAAAAGTCCGTCAAGTGGAAACAGAAGAGATGAGATCAGCAATTGCTCCTGATCCCATTCCTCTGACACGGGAGTCCACAGCTGATACTAGGG
CTTTGAATAGATGTAAAGCGATGAGTGGATCATTTCAGCGGGGTCGGTTCCAGGTGATTACAATTCCTCAGCAGCAGTCAGCAAAAATGACATCTTTTGG
AATAGAACACATATCAGTGTTCAGTGAGACAAACCATTCTAGTGAAGAAGCCTTTATTAAAACAGCAAAGTCTCAGTTGGTAGAAATAGAACCTGCCACA
CAAAATCCAAAAACTTCGTTTTCTTATGAGAAGTTACAAGCTCTTCAGGAAACCTGTAAAGAAAATAAAGGAGTTCCCAAACAAGGTGACAACTTCTTAT
CTTTCAGCGCAGCTTGTGAGACTGATGTATCTTCAGTGACCCCAGAAAAGGAATTTGAAGAAACTTCAGCCACAGGAAGTAGCATGCAGTCTGGATCTGA
ACTGTTGCTTAAAGAGAGAGAGATATTGACTGCTGGGAAACAGCCTAGCTCTGATAGTGAATTTTCAGCCAGTCTTGCTGGCAGTGGAAAGTCAGTGGCA
AAGACTGGTCCAGAGAGTAATCAGTGCTTACCACACCACGAAGAACAAGCTTATGCTCAAACACAGAGTTCACTCTTCTATTCGCCATCTTCCCCAATGA
GCAGTGATGATGAATCAGAAATAGAGGATGAGGACTTGAAGGTGGAGCTTCAAAGATTACGAGAAAAACACATTCAGGAGGTGGTAAATCTTCAAACCCA
GCAGAATAAGGAGCTGCAGGAGCTCTATGAACGCCTTCGGTCAATTAAAGATAGCAAAACCCAATCTACTGAGATTCCTTTGCCACCTGCATCACCACGT
CGACCAAGATCTTTCAAAAGCAAACTTCGAAGCCGCCCCCAGTCCTTGACACATGTGGACAATGGCATAGTTGCTACAGGGAAAAGCTGCCTTATAAATG
AGTTGGAAA
ATCCACTGTGTGTGGAGAGTAATGCAGCATCATGCCAACAGTCTCCAGCCAGTAAAAAAGGGATGTTCACAGATGACTTACACAAGCTGGT
GGATGACTGGACAAAGGAAGCAGTAGGAAATTCTCTTATTAAGCCAAGTTTAAACCAACTTAAACAAAGTCAACACAAACTAGAGACAGAAAACTGGAAT
AAAGTATCTGAAAATACTCCGTCTACTATGGGCTACACATCAACATGGATTTCTTCTCTGTCCCAAATCCGTGGAGCTGTCCCAACTTCCTTGCCACAAG
GACTCTCACTCCCTTCATTTCCTGGGCCATTATCATCATATGGAATGCCTCACGTTTGTCAGTATAATGCTGTGGCGGGGGCGGGGTATCCAGTACAGTG
GGTAGGAATTTCAGGAACAACACAACAATCTGTAGTAATTCCCGCCCAATCTGGGGGACCATTCCAGCCAGGGATGAATATGCAGGCATTTCCAACTTCA
TCAGTGCAGAATCCTGCCACAATCCCTCCTGGTCCTAAATGAATCAGAGTAGATGGTGATAAAAAGGGAGGTTTTTTCAGAATTATTTTCAGGACACCCA
AGATATTAAAGTTTCTTCCTCTTGGGTTCTGTCATATTTTCCCTCATTTGAGTTTACTTTAGACTATATATTTTTTGTTCCAGTGTGGTATTTGATACAG
CTCATCATTCTGTAGAAATGTGCAGTTTGCAGATAGAACACTGCACACAGAAATGTTTTTTCACTTCAAATTCTATCCTCTTTGATACTTGATTTTTTAA
AAATACTGTTCAGAATGCTTTAATAAGCTCAGCTTGAGCATTACCATTTCCAGGACACTTTCCATGAATTGTTGAGAAGCTCCCCATCCCCCGCCTTTTT
TTTTTTTTTTTTTAACTGCTGCTATCTGCAGCTGGATACTCTTCTTTAAAAATGTTTAAAAATTATTTAGATTGATTCTCCCCAAATGTGGATGAACTGA
GACCCTCCATCAGCCAGAGTCTTATGGGATCTTCACTTCACATGTTTGTCTTAGGTTTACCTTTCACAGAAGGCAGGGTAACTTGCTGCAGGAAACGTTT
TGGTGTATAAAATTAGAATCACTTTTTTTTTTTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAGGTTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCT
GCAACCTCCCCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCAGCCACCATGCCTGGCTAATTTTTGTATT
TTTAGTAGAGGATGGGGTTTCACTATGTTGGCCAGACTGGTCTCAAACTCCTAACCTTGTGATCCGCCCTCCTTAGCCCCCCCAAAAAATTACAATAATT
TTGTCAACCAATACAGAACATGAGCCCTTTTTAAATGTGATTTCCCGTCATCACAGCAGTAGGATGAAGCCTTGTTTTGGGTGAGACAGAGGGAAAGGGA
AAAAACAGAATTGTAACAGTTCCTTGATTCTGCAGATACTGCTGCTGTTTTACGATTTCAGTAATAATTCAAAGCAGCTGTCTCCTTGTTTCTCACATGC
ATACTACATTGGTTTTGAGCATCTGAGAGGCATTGGTTTGTCTTGCATTCTTTTGCAAGGCATATATTGCAGCTGATATGAATCTCGTTTGGGGGGAATC
CTTGTATTCCTAACAAGGGGGATTAAAGCTACACCTCAATCCATTCTTCTGAAGTGAAATTTACTTGACACAGTAGGTTTCGAGACTTACATATGAAACA
CTGGCTTTACAGGGTTCTCAGAGATGTGGGGTATACACTGTCCTGCAGTGAGATAGTAGACCCTAGAAGGATACTATTTAAGTTGTCCTTAGCTCTTTTT
AATTACAATTTTTAGTTGTTAGAATTTCTTTTTAGTATCTATAGTATCTTAGATGATTTTAGATCTTAAATGAGTTTGGCAGCCTCTTTAGAATCTGAGA
GAGATCACTGTCAAGTTGCACTTTACTGGGTTTTATCCAGTTTTAGGAGGAGGGGAGGCAATGTCAAAATGTACACCTTTGGTTTTTAAGAAGGTTAACT
ATAATAATGTTAAAGGCTAGTCACAGGGTTACCTAATGCTCAGTCTGTGAAACCTAAATAGAATTCTTAAAATGTTATTTACCAACTAAGTATTCATGTT
CAAATTACTTACCTTCCACTCTGAAGACTTTAAGGTCATTTCTAATACACATTTACCTAATTAGGAGTTCTGTCTACTAGTAAACATTCCAAATTGCTAC
CCAACATTACTGTTAACAGATTTTCCTCCGTATTCTTCTAAAAATTATACCCCATGGGCTTGCCAGGTAATGACGAAAACTTAATGGGTGTACTTTTTTT
TTTTTTTGCACAGTCTACTTTGTGACATTAAGTACCTCTTTTCC
  • refseq_WNK3.F3 (forward primer)
  • refseq_WNK3.R3 (reverse primer)
  • Single exon skipping

Frame 0

LSSGPSASLGSYPAPLSPPALYLPAVAGPVGSR
GDARARKRTRRGAELETSRRGVRSIGGGDRGGGG
VCVCVYSTVWLVVGREEARERAREKRKE*ESLP
LREPLIWLLWKYMTTQKEVHSDNSDT*DVTGLK
SRNRKNFSANFNYNGH*FRGSSQHRRF*ET*WNF
I*KQSSPGRCNFDSRS*TKGEKQYLLCFWGNCR
KEEIFPKEC*NDGR*QSCRIIPQR*EN*GCNEY
SKSR*ASFKCVERWTRS*I*TVFKVNLRNLKRLF
QGEK*KGNGRRSRNEGCSYFS*WQIPEI*HRTR
KRSI*NSI*RTGH*NMG*GCLV*AAGPKVNQS*
AAKIQGRSRDVEGSPAPQYSSIL*FLGIYIKRKE
MYCISD*TNDIWDLKDVLKTI*SHETKGLKELV
QANFKGVAVLAH*DSSYYSPGSEV*QYFHHGTH
WICEDW*SRISHLNAYLIC*ECHWNS*VYGSRDV
*RTL**IRRCLCFWNVYAGNGHIGVSLF*VSEC
SSNIPESN*WHKTSQLQ*SH*S*SQRNH*RMYS
SKQI*KVVYQGPIKPCIFC*GYRTEGGVSRRR*L
LKFIPCFKTLG*RP*KIERQTQRQ*SY*I*FQL
RNRYT*GSSI*NGQVWVLP*K*FQSCC*IH*RP
GDANKEDKREEACWLFGRTQGFSVQVYGECIPSA
PEYNFTPCSRSANWG*M*RN*S*STC*TTASTK
KTTAALLLCYR*QFV*GRSCISYTFRYFKSAQC
SLFLKSNDGLSNGF*YPAG*SKCSRANLFISATS
RTLPASFRVTEAFKADSAADFAFGSRSVHCFTC
TCPWTDSCFTTPGFPINCSEGPTDKACIPTSWS
*TTSSSSKTRFSSKLESRCGNYEGKRQ*P**PKW
KWQTGSDQTEKSFLSPTREGD*ISAYRPSGINL
WR*HGRVSAGDTQQQDGHLQV*C*W*CARGYCR
LYG*R*LCAGK*ERKICRRIESYCRSSPGDPSCP
LCHRKSHWS*FYYCGLQQ*PDRVI*TSTDKFYI
YSNQQ*ICSSVIPSWSVAILYQSDDKKP*DSVS
SFSSAFHVCGSWPTSTS*SKKHK**GNITGHIAH
YRK*SMPPCTFHLQIRTQGCG*W*DF*MC*CRN
QAASYTLSSGR*QADNGTSY**FQLLYYFSSCS
SS*M*GTHQTSKHIHTCVSMSPNCQSG*CTYVPS
WRINSDFW*LSYNSGI*SKASNLISTAASYGCR
VYFSRRRNYSEH*SKFS*DSHSHSDPWP*TNYP
STHYCPGIRWRKTSKTGVCRQPN*NSG*KIKKLA
LSGAQHL*HLSRESEGYPKHRLSIFFLC*RYPL
LSSDRSHSHQSLWN*R*PCTIP*FPTDRL*ASV
QCGCKSAC*YISVQKGPECDNFCTQRIVFT*DVL
RCFTSRGSRGLSCCCVKRWSHSSADRRWIFWPK
LYLS*SQKSY*QEILDSQIKKLGIQATAVNQLF
QEIKSPSSGNRRDEISNCS*SHSSDTGVHS*Y*G
FE*M*SDEWIISAGSVPGDYNSSAAVSKNDIFW
NRTHISVQ*DKPF**RSLY*NSKVSVGRNRTCH
TKSKNFVFL*EVTSSSGNL*RK*RSSQTR*QLLI
FQRSL*D*CIFSDPRKGI*RNFSHRK*HAVWI*
TVA*RERDIDCWETA*L***IFSQSCWQWKVSG
KDWSRE*SVLTTPRRTSLCSNTEFTLLFAIFPNE
Q***IRNRG*GLEGGASKITRKTHSGGGKSSNP
AE*GAAGAL*TPSVN*R*QNPIY*DSFATCITT
STKIFQKQTSKPPPVLDTCGQWHSCYREKLPYK*
VGK
STVCGE*CSIMPTVSSQ*KRDVHR*LTQAG
G*LDKGSSRKFSY*AKFKPT*TKSTQTRDRKLE
*SI*KYSVYYGLHINMDFFSVPNPWSCPNFLATR
TLTPFISWAIIIIWNASRLSV*CCGGGGVSSTV
GRNFRNNTTICSNSRPIWGTIPARDEYAGISNF
ISAESCHNPSWS*MNQSRW**KGRFFQNYFQDTQ
DIKVSSSWVLSYFPSFEFTLDYIFFVPVWYLIQ
LIIL*KCAVCR*NTAHRNVFSLQILSSLILDFL
KILFRML**AQLEHYHFQDTFHELLRSSPSPAFF
FFFFNCCYLQLDTLL*KCLKII*IDSPQMWMN*
DPPSARVLWDLHFTCLS*VYLSQKAG*LAAGNV
LVYKIRITFFFFFEMESLSVTQVGVQWCDLGSLL
QPPPPGFKRFSCLSLLSSWDYRRQPPCLANFCI
FSRGWGFTMLARLVSNS*PCDPPSLAPPKNYNN
FVNQYRT*ALFKCDFPSSQQ*DEALFWVRQRERE
KTEL*QFLDSADTAAVLRFQ**FKAAVSLFLTC
ILHWF*ASERHWFVLHSFARHILQLI*ISFGGN
PCIPNKGD*SYTSIHSSEVKFT*HSRFRDLHMKH
WLYRVLRDVGYTLSCSEIVDPRRILFKLSLALF
NYNF*LLEFLFSIYSILDDFRS*MSLAASLESE
RDHCQVALYWVLSSFRRRGGNVKMYTFGF*EG*L
**C*RLVTGLPNAQSVKPK*NS*NVIYQLSIHV
QITYLPL*RL*GHF*YTFT*LGVLSTSKHSKLL
PNITVNRFSSVFF*KLYPMGLPGNDENLMGVLFF
FFAQSTL*H*VPLF

Frame 1

SAPGRARAWARTPLPSLRPLFTYRP*LARWARG
ETLARASAHDAERSSRHRGEE*EASEEAIEEEA
VCVYVSILRCGSSWGERRLERGRGRSEKSKRVFL
CESL*SGCYGNT*PRKRKSILIILIPEM*LD*R
VETGKILVPTLITMATDSGDPASTEDSEKPDGI
SFENRVPQVAATLTVEARLKEKNSTFSASGETVE
RKRFFRKSVEMTEDDKVAESSPKDERIKAAMNI
PRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDC
FKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELG
RGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE
QQRFKEEAEMLKGLQHPNIVRFYDSWESILKGK
KCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWC
RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT
GSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM
YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNA
AQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR
QNKSERLSIRDLLNHAFFAEDTGLRVELAEEDD
CSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNL
ETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDR
VTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQ
PQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQR
KPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSV
AYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQL
VGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPV
HVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGA
EQQAALLKPDLVRSLNQDVATTKENVSSPDNPS
GNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTS
GDNMVECQLETHNNKMVTFKFDVDGDAPEDIAD
YMVEDNFVLESEKEKFVEELRAIVGQAQEILHV
HFATERATGVDSITVDSNSSQTGSSEQVQINSTS
TQTSNESAPQSSPVGRWRFCINQTIRNRETQSP
PSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLL
TIENNPCHRALFTSKSEHKDVVDGKISECASVET
KQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAV
PAECEGLTKQASIFIPVYPCHQTASQADALMSH
PGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAE
FISQEGETTVNTEASSPKTVIPTQTPGLEPTTL
QPTTVLESDGERPPKLEFADNRIKTLDEKLRNL
LYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLS
CPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLS
NVAASQPANISVFKRDLNVITSVPSELCLHEMS
SDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLS
FTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFF
KRSKVRQVETEEMRSAIAPDPIPLTRESTADTR
ALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFG
IEHISVFSETNHSSEEAFIKTAKSQLVEIEPAT
QNPKTSFSYEKLQALQETCKENKGVPKQGDNFL
SFSAACETDVSSVTPEKEFEETSATGSSMQSGSE
LLLKEREILTAGKQPSSDSEFSASLAGSGKSVA
KTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPM
SSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQ
QNKELQELYERLRSIKDSKTQSTEIPLPPASPR
RPRSFKSKLRSRPQSLTHVDNGIVATGKSCLIN
ELE
NPLCVESNAASCQQSPASKKGMFTDDLHKLV
DDWTKEAVGNSLIKPSLNQLKQSQHKLETENWN
KVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQ
GLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQW
VGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTS
SVQNPATIPPGPK*IRVDGDKKGGFFRIIFRTP
KILKFLPLGFCHIFPHLSLL*TIYFLFQCGI*YS
SSFCRNVQFADRTLHTEMFFHFKFYPL*YLIF*
KYCSECFNKLSLSITISRTLSMNC*EAPHPPPF
FFFFLTAAICSWILFFKNV*KLFRLILPKCG*TE
TLHQPESYGIFTSHVCLRFTFHRRQGNLLQETF
WCIKLESLFFFFLRWSLSLSPRLECSGVILAHC
CNLPLLGSSDSPASAS*VAGTTGASHHAWLIFVF
LVEDGVSLCWPDWSQTPNLVIRPP*PPQKITII
LSTNTEHEPFLNVISRHHSSRMKPCFG*DRGKG
KKQNCNSSLILQILLLFYDFSNNSKQLSPCFSHA
YYIGFEHLRGIGLSCILLQGIYCS*YESRLGGI
LVFLTRGIKATPQSILLK*NLLDTVGFETYI*N
TGFTGFSEMWGIHCPAVR**TLEGYYLSCP*LFL
ITIFSC*NFFLVSIVS*MILDLK*VWQPL*NLR
EITVKLHFTGFYPVLGGGEAMSKCTPLVFKKVN
YNNVKG*SQGYLMLSL*NLNRILKMLFTN*VFMF
KLLTFHSEDFKVISNTHLPN*EFCLLVNIPNCY
PTLLLTDFPPYSSKNYTPWACQVMTKT*WVYFF
FFLHSLLCDIKYLFS

Frame 2

QLRAERELGLVPRSPLSARSLPTGRSWPGGLAG
RRSRAQAHTTRSGARDIEERSKKHRRRRSRRRR
CVCMCLFYGVARRGARGGSREGEGEAKRVRESS
FARASNLVAMEIHDHAKGSPF**F*YLRCNWTEE
*KQEKF*CQL*LQWPLIQGIQPAQKILRNLMEF
HLKTEFPRSLQL*Q*KLD*RRKTVPSLLLGKL*
KGRDFSERVLK*RKMTKLPNHPPKMRELRLQ*IF
QE*ISFLQMC*EVDKKLNMNSVQSQPQKSQKIV
SRRKMKRKWKKKQK*RL*LLLLVADS*NLT*N*
EEEHLKQYIKDWTLKHGLRLLGVSCRTES*PKLS
SKDSRKKQRC*RVSSTPI*FDFMIPGNLY*KER
NVLY**LN**HLGP*RRT*NDLKS*NQRS*GAG
AGKF*RGCSSCTLGLLLLFTGI*SVTIFSSRDPL
DL*RLVI*D*PP*CVPHLLRVSLELLSLWLQRC
MKNTMMNP*MFMLLECVCWKWPHRSILILSVRM
QLKYTGK*LVA*NQPASIKSLILKSKKSLKDVFV
KTNLKGCLSGTY*TMHFLLRIQD*GWS*QKKMI
AQIHPLL*DSGLKTLKN*KANTKTMKLLNLVST
*KQIHLRK*HMKWSSLGSSMKVIPKLLLNPLETG
*RQ*RRQERRSLLAVWKNAGILSASLWGMYSLS
PRIQLYPLLPLSKLGLNVKKLKLINMLDNSFYK
ENHSSTAPLLQVTICLRQELHQLYIQILQVSPV*
PIPQIKRWALKWFLISRRLK*MFQGKFIHLSN*
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NNKQLF*NQI*FEA*IKMWQLRRKTSVALITQV
EMANRIGSNREELPVPDQRRGLNFSLPSFRYQP
LEITW*SVSWRHTTTRWSPSSLMLMVMRQRILQT
IWLKITLCWKVRKKNL*KN*ELL*VKPRRSFMS
TLPQKEPLELILLLWTPTVARQGHLNKYR*ILH
LLKPAMNLLLSHPQLVGGDSVSIRR*ETVRLSLL
LLFSIPCLRFLADIHFLVQKTQVIRKYHGTHCS
L*KIIHATVHFSPPNQNTRMWLMVRFLNVLV*K
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QLNVRDSPNKQAYSYLCIHVTKLPVRLMHLCPI
LANQLRLLVTLLQLWHLIKSLKPYQYSSQLWMQ
SLFLKKEKLQ*TLKQVLLRQSFPLRPLALNQLPF
NPLLSWNQMEKDLQNWSLQTTELKLWMKN*ETC
SIRSTASLASIPRVRRIPKA*TLHFLPLLKIPS
PVQ*QKS*PSVTVELKIALYNPLISNRQALSFCP
MWLQVSLLIYQCSKGT*M**LLYPANCVYMRCP
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ALLVLVSKILLARNPGLAN*KAGHTGYGSQPAFS
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E*NTYQCSVRQTILVKKPLLKQQSLSW*K*NLPH
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SWK
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KYLKILRLLWATHQHGFLLCPKSVELSQLPCHK
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F**RMGFHYVGQTGLKLLTL*SALLSPPKKLQ*F
CQPIQNMSPF*M*FPVITAVG*SLVLGETEGKG
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HTTLVLSI*EALVCLAFFCKAYIAADMNLVWGES
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LALQGSQRCGVYTVLQ*DSRP*KDTI*VVLSSF
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RSLSSCTLLGFIQF*EEGRQCQNVHLWFLRRLT
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