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Sequences

Sequence NM_016003

GTGCGTCGCGGGGGCGGGGCCGCGCAGGCGTACCGGGTGCCCCGGCTCTGGAGCATAAACAAGAGCGGGGACGGGATGAGGCGGCGGTTGATCCCAGGGT GGCGAGTGGCGGCGACCGAGGCGGCGAGCGGGGCCCGGCGCCGACCCTGAGTGCAGCCTGACCCGCCCTCGCGCGCGCGCCCTCCCCGGCCGGGCCCACT CGCCGCGCGCCCAGCCATGAACCTGGCGAGCCAGAGCGGGGAGGCCGGCGCCGGCCAGCTGCTCTTCGCCAACTTCAACCAGGACAACACGTCCCTAGCT GTTGGTAGTAAGTCCGGTTATAAATTTTTCTCCCTTTCTTCTGTGGATAAGCTGGAACAGATCTATGAATGCACCGATACGGAAGATGTGTGCATTGTAG AGAGATTGTTCTCCAGCAGCCTAGTGGCCATCGTCAGCCTTAAAGCACCAAGGAAGCTAAAGGTTTGCCACTTTAAGAAGGGAACTGAGATCTGCAACTA CAGCTACTCCAACACGATTCTGGCTGTGAAGCTCAACAGGCAGAGGCTGATAGTATGCCTGGAGGAGTCCCTGTACATCCACAACATTCGGGACATGAAG GTGCTGCATACGATCAGGGAGACGCCTCCAAACCCTGCAGGCCTGTGTGCGCTGTCAATCAACAACGACAACTGCTACTTGGCGTACCCAGGGAGCGCGA CCATCGGAGAGGTGCAGGTCTTCGATACCATTAATTTGAGAGCTGCAAACATGATTCCGGCTCACGACAGTCCTTTAGCGGCACTGGCCTTTGACGCAAG TGGAACTAAACTTGCCACGGCTTCGGAGAAGGGGACCGTGATTAGGGTATTTTCCATTCCAGAAGGACAAAAACTCTTTGAGTTTCGGAGAGGAGTAAAG AGGTGCGTGAGCATCTGCTCCCTGGCCTTCAGCATGGACGGCATGTTCCTCTCCGCCTCCAGCAACACTGAGACCGTGCACATCTTCAAACTCGAGACTG TGAAAGAAAAACCCCCAGAGGAGCCCACCACCTGGACCGGGTACTTCGGGAAAGTGCTCATGGCCTCCACCAGCTACCTGCCTTCCCAAGTGACAGAAAT GTTCAACCAGGGCAGAGCCTTCGCCACGGTCCGCCTGCCATTCTGCGGCCACAAAAACATCTGCTCGCTAGCCACAATTCAGAAGATCCCGCGGTTGTTG GTGGGTGCCGCCGACGGGTACCTGTACATGTACAACCTGGACCCCCAGGAGGGCGGCGAGTGTGCCCTGATGAAGCAGCACCGGCTGGACGGCAGTCTGG AAACGACCAATGAGATCTTGGACTCTGCCTCTCACGACTGCCCCTTAGTCACTCAGACATACGGCGCAGCTGCAGGAAAAGGTACTTACGTGCCTTCATC CCCAACGAGACTTGCCTACACAGACGACCTGGGTGCTGTGGGTGGCGCCTGCCTGGAGGACGAGGCCAGCGCCCTGCGCCTGGATGAGGACAGCGAGCAC CCGCCCATGATTCTTCGGACTGACTGAACTTGACCTGTGACCTCTGACCCGGGGAGCAGAGAACACTGGCTTCACAGAGGACTTTGTGCATTGCTGCTAT GAACTTTGACCTGAGTCGGGGGAGAGGATGGCAGAGACTTTATTAAAAAAAAAAAAAGATTGTAGTGGTAGTCTAACTCCATAACGCTGAGGAAATACAT CATTTTCACTTCAGTGGCTTTTAAATCCTGCTTATGAATTTTAGCTTTTTGTTTGTTTGTTTTCTCTTTTTGCCAAAATTAACTGTTTGGTGAAGCCCGC AAAACCTCCTCGCTTTGCATGCATGAACGTGCCAAGCCAGCATAGGGGAGCTAGAAGCCACTTTCCAGCCACCTGCCGTTGGGTTTTTTCATATCTGTAC ATAATGCCGAGTGCGTAAGGAAACCGTGGCGTCGCGCACAGTGGGTCTGCTTGTCAAGGCCAGTTCTGCAGTGACAGGCCCAGGGGCTGCCCACCAGGTG TGCTGGGCAGACTTCAGCTGGGACAGAAGTCCGATCTCCCTAGGGCCCCACCTGGACCATTTTCCCTCCGTTTTATTTTGTTAATTAAATTCTTTCCAAA TTGGATCGCTCTGGGATTTCTTCCATGGTGGACTTTTGTTTCTGATCTTGTTTTCCCTGTGGATATTGGAGGACAGCGAGGTTCTTTCTGATACTAAAAA CCTTTCTTTCAGGCAGCAAATGAACTTGAAAGGTTGCCTGGACTCGCTGGAGCAAAGGAAAGCGATTTTGTTTGTATAATTAAATGATCTGTTCTTCTAC TTCACTCTTCCTGTTGAAAAACTGTGTGATTTTTTTTTTTTTTTAAGTAAAGTTTGTAGCTCCTCCCATGCCCAGGAAAGCACAGAACTCAAGTGTGGTG GCCGTCTGAGCTGTCCTTTCGCTGGCCCCGCTGTCCGCAGGGGCTTCCTACCTGTGTGAGAGGTCGTAGCGGGAGACAGCAACAGAGAGTAGGCGGCTGG GCCACGTCCTTCACAGGGCGTCATGTGCCTTTCTATTTTCATCTTAGAAAATTTCCTCAGCAAACCGATGAGAGATTGTGGTTGCAAGCTTCAGTATTTG CCTCGCTTCCCTTCCCTTTTCATATTTACAGAATTAAAACAACCTCAAGTACCTCAGACTCTGCATTCCAAACCAAGGCACCCAGCAGCCAAAGTGTCGA GGGCATTTAAGTGGCATTAATGGCAGGAGAGATGGTTTTAGAATCTATGGAGTGGTGGAAGTTACGGATAGAAGGGAAAAGGCAAAAACTATTTACCCTG CCTTTGCAGGCTGGGGTTTTTGAACCGAGGAAGGCTGGGACGCCTGTTTCCAGATGGTTGTCATGGTCACGCTGGGCGAAGAGCTGGAGGGGAGTTGTCC CCTCAGCTGAGCGGCTGCGGTGAAATGCCCCAGTGTTCCTGGGTTGGCTTTACGGCAAACTAAATGCAGGGGACGCTGGAGTCCGACTCACCTACACCGG CTTCCTCCCAGCCGCTGGTGTGCGGCACACACAACATCTGCATTAGGCAGAGGTGCAAGTGGGCTGATTGAACTTTTCCTTCAAAACCTGCTTGTCTGTC CTGGACCTTTGATGAAATGGGATCCCGGTCACGCAGGCTGAGACAGTGGGGACCGCCGAGGCCAGAGTGGGCTATGCTTGAGCAGGGATGAGAAGGGCCG CGGCAGCACGCAGCCTTGACCCACGCCTGCGTCTTGTGGTGCAAGGCCAGAGGGCTCTCTCTAGAACCTGACCGTGCACTCCATCTCCTGGGAGCCACTT TTGGCAAGAGTGAGTGTGGGGGGAAAAAGTGTGCACAAGAGATACGGAACCCTGAGCTAGGGTTTCCTGTCACCAAAGAGTGAGCTGCATTTCCAGTTCT GCGTTAAAGTATCGTTTGTTCTGGTGCCTGCCTGTGGTGGTGATTTGGAGACTCAAATTTCCTTTGCCAGGTCTCTTTTGTCTTTCTTTGGGATTGGTAG TATAGAAGATGCTGGGAATTGTCTTCCTCGCTCAGCCTCGGCTTCCCGCACTGTAAGATGAGGCAGTTGCAGAGGAGGCCTCGGACGTCCTGTGACCCTC GGCCCACACTCCCCCTTGGGTGGCCCTGGCAGGGCTGGCTAGGTGCGTTCCCTGCAGACCACGGGAAGCCCTGTGCTTGCCTGGGTCAGGGCTAAGCTGT GCGCCCTAGAGGAGGGAGGAGGACTGCAGATTCTTGGTCGAGAAGAATGAAGAGGATTTCTGTGTTTGCTGAGCAGCCATTGTGGAGGGTTACCCGCCTC CACTTTCCCGTTGCCCATTTCACTGCCACCAGCTCCTCTTCCTCTGCTCGAACCTATGAGTCCCAGCCTCACTGGCGGCCTCAGACATGCTCAGGAGTGA CGGGGACAGAGGGAGGCCGCTGAGTTGCCCGTTAGAACTCTTACTGCTGCGCCAGTGACCCAGGTGGAGAGGGACCCTGAACCAAACAGAACGTGTGCTA ATTTTCCGAACTCCAAACTGTACACTCATATTCATTTTTAAATTGTATTTTTCCAAACTTCAAAAAGGACGATGAGCGTGGGGGATAGGAAACAAAACCT GTAAACGTTGTGAATGGGCTCAGTGGACTCTGGGACCAAACCTTCTGTAATCTCTAAAACAATGGGACCAAGAGCTGGATGGAACCTGGAGTCAAAAAGA ACTGCTTCAGTCCCCGCTGTACCGCCTGCCTAGCTGTGGGAGCAGGCAGGGCGCCTGGGAGCCTGCGTTTTCTGGACCGTTCCATGGGACTCATCCCTAC CTCACAGGGCTGTTGTGAGGTGTTGTGTGACTGCGTGTCCTGCAAACGCCCAGCTCGGTGCCCAGCCAGCGGTGGGCACCCAATAAACGCTACAACATAA ATGTGTCTTCTGCAATTAAACACGATTTTTATTCA

refseq_WIPI2.F1 (forward primer)
refseq_WIPI2.R1 (reverse primer)
Single exon skipping

Frame 0

VRRGGGAAQAYRVPRLWSINKSGDGMRRRLIPG WRVAATEAASGARRRP*VQPDPPSRARPPRPGPL AARPAMNLASQSGEAGAGQLLFANFNQDNTSLA VGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIV ERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNY SYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK VLHTIRETPPNPAGLCALSINNDNCYLAYPGSA TIGEVQVFDTINLRAANMIPAHDSPLAALAFDAS GTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK RCVSICSLAFSMDGMFLSASSNTETVHIFKLET VKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM FNQGRAFATVRLPFCGHKNICSLATIQKIPRLL VGAADGYLYMYNLDPQEGGECALMKQHRLDGSL ETTNEILDSASHDCPLVTQTYGAAAGKGTYVPSS PTRLAYTDDLGAVGGACLEDEASALRLDEDSEH PPMILRTD*T*PVTSDPGSREHWLHRGLCALLL *TLT*VGGEDGRDFIKKKKRL*W*SNSITLRKYI IFTSVAFKSCL*ILAFCLFVFSFCQN*LFGEAR KTSSLCMHERAKPA*GS*KPLSSHLPLGFFISV HNAECVRKPWRRAQWVCLSRPVLQ*QAQGLPTRC AGQTSAGTEVRSP*GPTWTIFPPFYFVN*ILSK LDRSGISSMVDFCF*SCFPCGYWRTARFFLILK TFLSGSK*T*KVAWTRWSKGKRFCLYN*MICSST SLFLLKNCVIFFFF*VKFVAPPMPRKAQNSSVV AV*AVLSLAPLSAGASYLCERS*RETATESRRL GHVLHRASCAFLFSS*KISSANR*EIVVASFSIC LASLPFSYLQN*NNLKYLRLCIPNQGTQQPKCR GHLSGINGRRDGFRIYGVVEVTDRREKAKTIYP AFAGWGF*TEEGWDACFQMVVMVTLGEELEGSCP LS*AAAVKCPSVPGLALRQTKCRGRWSPTHLHR LPPSRWCAAHTTSALGRGASGLIELFLQNLLVC PGPLMKWDPGHAG*DSGDRRGQSGLCLSRDEKGR GSTQP*PTPASCGARPEGSL*NLTVHSISWEPL LARVSVGGKSVHKRYGTLS*GFLSPKSELHFQF CVKVSFVLVPACGGDLETQISFARSLLSFFGIGS IEDAGNCLPRSASASRTVR*GSCRGGLGRPVTL GPHSPLGGPGRAG*VRSLQTTGSPVLAWVRAKL CALEEGGGLQILGREE*RGFLCLLSSHCGGLPAS TFPLPISLPPAPLPLLEPMSPSLTGGLRHAQE* RGQREAAELPVRTLTAAPVTQVERDPEPNRTCA NFPNSKLYTHIHF*IVFFQTSKRTMSVGDRKQNL *TL*MGSVDSGTKPSVISKTMGPRAGWNLESKR TASVPAVPPA*LWEQAGRLGACVFWTVPWDSSL PHRAVVRCCVTACPANAQLGAQPAVGTQ*TLQHK CVFCN*TRFLF

Frame 1

CVAGAGPRRRTGCPGSGA*TRAGTG*GGG*SQG GEWRRPRRRAGPGADPECSLTRPRARALPGRAH SPRAQP*TWRARAGRPAPASCSSPTSTRTTRP*L LVVSPVINFSPFLLWISWNRSMNAPIRKMCAL* RDCSPAA*WPSSALKHQGS*RFATLRRELRSAT TATPTRFWL*SSTGRG**YAWRSPCTSTTFGT*R CCIRSGRRLQTLQACVRCQSTTTTATWRTQGAR PSERCRSSIPLI*ELQT*FRLTTVL*RHWPLTQ VELNLPRLRRRGP*LGYFPFQKDKNSLSFGEE*R GA*ASAPWPSAWTACSSPPPATLRPCTSSNSRL *KKNPQRSPPPGPGTSGKCSWPPPATCLPK*QK CSTRAEPSPRSACHSAATKTSAR*PQFRRSRGCW WVPPTGTCTCTTWTPRRAASVP**SSTGWTAVW KRPMRSWTLPLTTAP*SLRHTAQLQEKVLTCLH PQRDLPTQTTWVLWVAPAWRTRPAPCAWMRTAST RP*FFGLTELDL*PLTRGAENTGFTEDFVHCCY EL*PESGERMAETLLKKKKDCSGSLTP*R*GNT SFSLQWLLNPAYEF*LFVCLFSLFAKINCLVKPA KPPRFACMNVPSQHRGARSHFPATCRWVFSYLY IMPSA*GNRGVAHSGSACQGQFCSDRPRGCPPG VLGRLQLGQKSDLPRAPPGPFSLRFILLIKFFPN WIALGFLPWWTFVSDLVFPVDIGGQRGSF*Y*K PFFQAANELERLPGLAGAKESDFVCIIK*SVLL LHSSC*KTV*FFFFFK*SL*LLPCPGKHRTQVWW PSELSFRWPRCPQGLPTCVRGRSGRQQQRVGGW ATSFTGRHVPFYFHLRKFPQQTDERLWLQASVF ASLPFPFHIYRIKTTSSTSDSAFQTKAPSSQSVE GI*VALMAGEMVLESMEWWKLRIEGKRQKLFTL PLQAGVFEPRKAGTPVSRWLSWSRWAKSWRGVV PSAERLR*NAPVFLGWLYGKLNAGDAGVRLTYTG FLPAAGVRHTQHLH*AEVQVG*LNFSFKTCLSV LDL**NGIPVTQAETVGTAEARVGYA*AGMRRA AAARSLDPRLRLVVQGQRALSRT*PCTPSPGSHF WQE*VWGEKVCTRDTEP*ARVSCHQRVSCISSS ALKYRLFWCLPVVVIWRLKFPLPGLFCLSLGLV V*KMLGIVFLAQPRLPAL*DEAVAEEASDVL*PS AHTPPWVALAGLARCVPCRPREALCLPGSGLSC AP*RREEDCRFLVEKNEEDFCVC*AAIVEGYPP PLSRCPFHCHQLLFLCSNL*VPASLAASDMLRSD GDRGRPLSCPLELLLLRQ*PRWRGTLNQTERVL IFRTPNCTLIFIFKLYFSKLQKGR*AWGIGNKT CKRCEWAQWTLGPNLL*SLKQWDQELDGTWSQKE LLQSPLYRLPSCGSRQGAWEPAFSGPFHGTHPY LTGLL*GVV*LRVLQTPSSVPSQRWAPNKRYNI NVSSAIKHDFYS

Frame 2

ASRGRGRAGVPGAPALEHKQERGRDEAAVDPRV ASGGDRGGERGPAPTLSAA*PALARAPSPAGPT RRAPSHEPGEPERGGRRRPAALRQLQPGQHVPS CW**VRL*IFLPFFCG*AGTDL*MHRYGRCVHCR EIVLQQPSGHRQP*STKEAKGLPL*EGN*DLQL QLLQHDSGCEAQQAEADSMPGGVPVHPQHSGHE GAAYDQGDASKPCRPVCAVNQQRQLLLGVPRERD HRRGAGLRYH*FESCKHDSGSRQSFSGTGL*RK WN*TCHGFGEGDRD*GIFHSRRTKTL*VSERSK EVREHLLPGLQHGRHVPLRLQQH*DRAHLQTRDC ERKTPRGAHHLDRVLRESAHGLHQLPAFPSDRN VQPGQSLRHGPPAILRPQKHLLASHNSEDPAVV GGCRRRVPVHVQPGPPGGRRVCPDEAAPAGRQSG NDQ*DLGLCLSRLPLSHSDIRRSCRKRYLRAFI PNETCLHRRPGCCGWRLPGGRGQRPAPG*GQRA PAHDSSD*LNLTCDL*PGEQRTLASQRTLCIAAM NFDLSRGRGWQRLY*KKKKIVVVV*LHNAEEIH HFHFSGF*ILLMNFSFLFVCFLFLPKLTVW*SP QNLLALHA*TCQASIGELEATFQPPAVGFFHICT *CRVRKETVASRTVGLLVKASSAVTGPGAAHQV CWADFSWDRSPISLGPHLDHFPSVLFC*LNSFQ IGSLWDFFHGGLLFLILFSLWILEDSEVLSDTKN LSFRQQMNLKGCLDSLEQRKAILFV*LNDLFFY FTLPVEKLCDFFFFLSKVCSSSHAQESTELKCG GRLSCPFAGPAVRRGFLPV*EVVAGDSNRE*AAG PRPSQGVMCLSIFILENFLSKPMRDCGCKLQYL PRFPSLFIFTELKQPQVPQTLHSKPRHPAAKVS RAFKWH*WQERWF*NLWSGGSYG*KGKGKNYLPC LCRLGFLNRGRLGRLFPDGCHGHAGRRAGGELS PQLSGCGEMPQCSWVGFTAN*MQGTLESDSPTP ASSQPLVCGTHNICIRQRCKWAD*TFPSKPACLS WTFDEMGSRSRRLRQWGPPRPEWAMLEQG*EGP RQHAALTHACVLWCKARGLSLEPDRALHLLGAT FGKSECGGKKCAQEIRNPELGFPVTKE*AAFPVL R*SIVCSGACLWW*FGDSNFLCQVSFVFLWDW* YRRCWELSSSLSLGFPHCKMRQLQRRPRTSCDP RPTLPLGWPWQGWLGAFPADHGKPCACLGQG*AV RPRGGRRTADSWSRRMKRISVFAEQPLWRVTRL HFPVAHFTATSSSSSARTYESQPHWRPQTCSGV TGTEGGR*VAR*NSYCCASDPGGEGP*TKQNVC* FSELQTVHSYSFLNCIFPNFKKDDERGG*ETKP VNVVNGLSGLWDQTFCNL*NNGTKSWMEPGVKK NCFSPRCTACLAVGAGRAPGSLRFLDRSMGLIPT SQGCCEVLCDCVSCKRPARCPASGGHPINATT* MCLLQLNTIFI

Sequence NM_001033519

GTGCGTCGCGGGGGCGGGGCCGCGCAGGCGTACCGGGTGCCCCGGCTCTGGAGCATAAACAAGAGCGGGGACGGGATGAGGCGGCGGTTGATCCCAGGGT GGCGAGTGGCGGCGACCGAGGCGGCGAGCGGGGCCCGGCGCCGACCCTGAGTGCAGCCTGACCCGCCCTCGCGCGCGCGCCCTCCCCGGCCGGGCCCACT CGCCGCGCGCCCAGCCATGAACCTGGCGAGCCAGAGCGGGGAGGCCGGCGCCGGCCAGCTGCTCTTCGCCAACTTCAACCAGGACAACACGTCCCTAGCT GTTGGTAGTAAGTCCGGTTATAAATTTTTCTCCCTTTCTTCTGTGGATAAGCTGGAACAGATCTATGAATGCACCGATACGGAAGATGTGTGCATTGTAG AGAGATTGTTCTCCAGCAGCCTAGTGGCCATCGTCAGCCTTAAAGCACCAAGGAAGCTAAAGGTTTGCCACTTTAAGAAGGGAACTGAGATCTGCAACTA CAGCTACTCCAACACGATTCTGGCTGTGAAGCTCAACAGGCAGAGGCTGATAGTATGCCTGGAGGAGTCCCTGTACATCCACAACATTCGGGACATGAAG GTGCTGCATACGATCAGGGAGACGCCTCCAAACCCTGCAGGCCTGTGTGCGCTGTCAATCAACAACGACAACTGCTACTTGGCGTACCCAGGGAGCGCGA CCATCGGAGAGGTGCAGGTCTTCGATACCATTAATTTGAGAGCTGCAAACATGATTCCGGCTCACGACAGTCCTTTAGCGGCACTGGCCTTTGACGCAAG TGGAACTAAACTTGCCACGGCTTCGGAGAAGGGGACCGTGATTAGGGTATTTTCCATTCCAGAAGGACAAAAACTCTTTGAGTTTCGGAGAGGAGTAAAG AGGTGCGTGAGCATCTGCTCCCTGGCCTTCAGCATGGACGGCATGTTCCTCTCCGCCTCCAGCAACACTGAGACCGTGCACATCTTCAAACTCGAGACTG TGAAAGAAAAACCCCCAGAGGAGCCCACCACCTGGACCGGGTACTTCGGGAAAGTGCTCATGGCCTCCACCAGCTACCTGCCTTCCCAAGTGACAGAAAT GTTCAACCAGGGCAGAGCCTTCGCCACGGTCCGCCTGCCATTCTGCGGCCACAAAAACATCTGCTCGCTAGCCACAATTCAGAAGATCCCGCGGTTGTTG GTGGGTGCCGCCGACGGGTACCTGTACATGTACAACCTGGACCCCCAGGAGGGCGGCGAGTGTGCCCTGATGAAGCAGCACCGGCTGGACGGCAGTCTGG AAACGACCAATGAGATCTTGGACTCTGCCTCTCACGACTGCCCCTTAGTCACTCAGACATACGGCGCAGCTGCAGGAAAAGCCTACACAGACGACCTGGG TGCTGTGGGTGGCGCCTGCCTGGAGGACGAGGCCAGCGCCCTGCGCCTGGATGAGGACAGCGAGCACCCGCCCATGATTCTTCGGACTGACTGAACTTGA CCTGTGACCTCTGACCCGGGGAGCAGAGAACACTGGCTTCACAGAGGACTTTGTGCATTGCTGCTATGAACTTTGACCTGAGTCGGGGGAGAGGATGGCA GAGACTTTATTAAAAAAAAAAAAAGATTGTAGTGGTAGTCTAACTCCATAACGCTGAGGAAATACATCATTTTCACTTCAGTGGCTTTTAAATCCTGCTT ATGAATTTTAGCTTTTTGTTTGTTTGTTTTCTCTTTTTGCCAAAATTAACTGTTTGGTGAAGCCCGCAAAACCTCCTCGCTTTGCATGCATGAACGTGCC AAGCCAGCATAGGGGAGCTAGAAGCCACTTTCCAGCCACCTGCCGTTGGGTTTTTTCATATCTGTACATAATGCCGAGTGCGTAAGGAAACCGTGGCGTC GCGCACAGTGGGTCTGCTTGTCAAGGCCAGTTCTGCAGTGACAGGCCCAGGGGCTGCCCACCAGGTGTGCTGGGCAGACTTCAGCTGGGACAGAAGTCCG ATCTCCCTAGGGCCCCACCTGGACCATTTTCCCTCCGTTTTATTTTGTTAATTAAATTCTTTCCAAATTGGATCGCTCTGGGATTTCTTCCATGGTGGAC TTTTGTTTCTGATCTTGTTTTCCCTGTGGATATTGGAGGACAGCGAGGTTCTTTCTGATACTAAAAACCTTTCTTTCAGGCAGCAAATGAACTTGAAAGG TTGCCTGGACTCGCTGGAGCAAAGGAAAGCGATTTTGTTTGTATAATTAAATGATCTGTTCTTCTACTTCACTCTTCCTGTTGAAAAACTGTGTGATTTT TTTTTTTTTTTAAGTAAAGTTTGTAGCTCCTCCCATGCCCAGGAAAGCACAGAACTCAAGTGTGGTGGCCGTCTGAGCTGTCCTTTCGCTGGCCCCGCTG TCCGCAGGGGCTTCCTACCTGTGTGAGAGGTCGTAGCGGGAGACAGCAACAGAGAGTAGGCGGCTGGGCCACGTCCTTCACAGGGCGTCATGTGCCTTTC TATTTTCATCTTAGAAAATTTCCTCAGCAAACCGATGAGAGATTGTGGTTGCAAGCTTCAGTATTTGCCTCGCTTCCCTTCCCTTTTCATATTTACAGAA TTAAAACAACCTCAAGTACCTCAGACTCTGCATTCCAAACCAAGGCACCCAGCAGCCAAAGTGTCGAGGGCATTTAAGTGGCATTAATGGCAGGAGAGAT GGTTTTAGAATCTATGGAGTGGTGGAAGTTACGGATAGAAGGGAAAAGGCAAAAACTATTTACCCTGCCTTTGCAGGCTGGGGTTTTTGAACCGAGGAAG GCTGGGACGCCTGTTTCCAGATGGTTGTCATGGTCACGCTGGGCGAAGAGCTGGAGGGGAGTTGTCCCCTCAGCTGAGCGGCTGCGGTGAAATGCCCCAG TGTTCCTGGGTTGGCTTTACGGCAAACTAAATGCAGGGGACGCTGGAGTCCGACTCACCTACACCGGCTTCCTCCCAGCCGCTGGTGTGCGGCACACACA ACATCTGCATTAGGCAGAGGTGCAAGTGGGCTGATTGAACTTTTCCTTCAAAACCTGCTTGTCTGTCCTGGACCTTTGATGAAATGGGATCCCGGTCACG CAGGCTGAGACAGTGGGGACCGCCGAGGCCAGAGTGGGCTATGCTTGAGCAGGGATGAGAAGGGCCGCGGCAGCACGCAGCCTTGACCCACGCCTGCGTC TTGTGGTGCAAGGCCAGAGGGCTCTCTCTAGAACCTGACCGTGCACTCCATCTCCTGGGAGCCACTTTTGGCAAGAGTGAGTGTGGGGGGAAAAAGTGTG CACAAGAGATACGGAACCCTGAGCTAGGGTTTCCTGTCACCAAAGAGTGAGCTGCATTTCCAGTTCTGCGTTAAAGTATCGTTTGTTCTGGTGCCTGCCT GTGGTGGTGATTTGGAGACTCAAATTTCCTTTGCCAGGTCTCTTTTGTCTTTCTTTGGGATTGGTAGTATAGAAGATGCTGGGAATTGTCTTCCTCGCTC AGCCTCGGCTTCCCGCACTGTAAGATGAGGCAGTTGCAGAGGAGGCCTCGGACGTCCTGTGACCCTCGGCCCACACTCCCCCTTGGGTGGCCCTGGCAGG GCTGGCTAGGTGCGTTCCCTGCAGACCACGGGAAGCCCTGTGCTTGCCTGGGTCAGGGCTAAGCTGTGCGCCCTAGAGGAGGGAGGAGGACTGCAGATTC TTGGTCGAGAAGAATGAAGAGGATTTCTGTGTTTGCTGAGCAGCCATTGTGGAGGGTTACCCGCCTCCACTTTCCCGTTGCCCATTTCACTGCCACCAGC TCCTCTTCCTCTGCTCGAACCTATGAGTCCCAGCCTCACTGGCGGCCTCAGACATGCTCAGGAGTGACGGGGACAGAGGGAGGCCGCTGAGTTGCCCGTT AGAACTCTTACTGCTGCGCCAGTGACCCAGGTGGAGAGGGACCCTGAACCAAACAGAACGTGTGCTAATTTTCCGAACTCCAAACTGTACACTCATATTC ATTTTTAAATTGTATTTTTCCAAACTTCAAAAAGGACGATGAGCGTGGGGGATAGGAAACAAAACCTGTAAACGTTGTGAATGGGCTCAGTGGACTCTGG GACCAAACCTTCTGTAATCTCTAAAACAATGGGACCAAGAGCTGGATGGAACCTGGAGTCAAAAAGAACTGCTTCAGTCCCCGCTGTACCGCCTGCCTAG CTGTGGGAGCAGGCAGGGCGCCTGGGAGCCTGCGTTTTCTGGACCGTTCCATGGGACTCATCCCTACCTCACAGGGCTGTTGTGAGGTGTTGTGTGACTG CGTGTCCTGCAAACGCCCAGCTCGGTGCCCAGCCAGCGGTGGGCACCCAATAAACGCTACAACATAAATGTGTCTTCTGCAATTAAACACGATTTTTATT CA

refseq_WIPI2.F1 (forward primer)
refseq_WIPI2.R1 (reverse primer)
Single exon skipping

Frame 0

VRRGGGAAQAYRVPRLWSINKSGDGMRRRLIPG WRVAATEAASGARRRP*VQPDPPSRARPPRPGPL AARPAMNLASQSGEAGAGQLLFANFNQDNTSLA VGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIV ERLFSSSLVAIVSLKAPRKLKVCHFKKGTEICNY SYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK VLHTIRETPPNPAGLCALSINNDNCYLAYPGSA TIGEVQVFDTINLRAANMIPAHDSPLAALAFDAS GTKLATASEKGTVIRVFSIPEGQKLFEFRRGVK RCVSICSLAFSMDGMFLSASSNTETVHIFKLET VKEKPPEEPTTWTGYFGKVLMASTSYLPSQVTEM FNQGRAFATVRLPFCGHKNICSLATIQKIPRLL VGAADGYLYMYNLDPQEGGECALMKQHRLDGSL ETTNEILDSASHDCPLVTQTYGAAAGKAYTDDLG AVGGACLEDEASALRLDEDSEHPPMILRTD*T* PVTSDPGSREHWLHRGLCALLL*TLT*VGGEDG RDFIKKKKRL*W*SNSITLRKYIIFTSVAFKSCL *ILAFCLFVFSFCQN*LFGEARKTSSLCMHERA KPA*GS*KPLSSHLPLGFFISVHNAECVRKPWR RAQWVCLSRPVLQ*QAQGLPTRCAGQTSAGTEVR SP*GPTWTIFPPFYFVN*ILSKLDRSGISSMVD FCF*SCFPCGYWRTARFFLILKTFLSGSK*T*K VAWTRWSKGKRFCLYN*MICSSTSLFLLKNCVIF FFF*VKFVAPPMPRKAQNSSVVAV*AVLSLAPL SAGASYLCERS*RETATESRRLGHVLHRASCAF LFSS*KISSANR*EIVVASFSICLASLPFSYLQN *NNLKYLRLCIPNQGTQQPKCRGHLSGINGRRD GFRIYGVVEVTDRREKAKTIYPAFAGWGF*TEE GWDACFQMVVMVTLGEELEGSCPLS*AAAVKCPS VPGLALRQTKCRGRWSPTHLHRLPPSRWCAAHT TSALGRGASGLIELFLQNLLVCPGPLMKWDPGH AG*DSGDRRGQSGLCLSRDEKGRGSTQP*PTPAS CGARPEGSL*NLTVHSISWEPLLARVSVGGKSV HKRYGTLS*GFLSPKSELHFQFCVKVSFVLVPA CGGDLETQISFARSLLSFFGIGSIEDAGNCLPRS ASASRTVR*GSCRGGLGRPVTLGPHSPLGGPGR AG*VRSLQTTGSPVLAWVRAKLCALEEGGGLQI LGREE*RGFLCLLSSHCGGLPASTFPLPISLPPA PLPLLEPMSPSLTGGLRHAQE*RGQREAAELPV RTLTAAPVTQVERDPEPNRTCANFPNSKLYTHI HF*IVFFQTSKRTMSVGDRKQNL*TL*MGSVDSG TKPSVISKTMGPRAGWNLESKRTASVPAVPPA* LWEQAGRLGACVFWTVPWDSSLPHRAVVRCCVT ACPANAQLGAQPAVGTQ*TLQHKCVFCN*TRFLF

Frame 1

CVAGAGPRRRTGCPGSGA*TRAGTG*GGG*SQG GEWRRPRRRAGPGADPECSLTRPRARALPGRAH SPRAQP*TWRARAGRPAPASCSSPTSTRTTRP*L LVVSPVINFSPFLLWISWNRSMNAPIRKMCAL* RDCSPAA*WPSSALKHQGS*RFATLRRELRSAT TATPTRFWL*SSTGRG**YAWRSPCTSTTFGT*R CCIRSGRRLQTLQACVRCQSTTTTATWRTQGAR PSERCRSSIPLI*ELQT*FRLTTVL*RHWPLTQ VELNLPRLRRRGP*LGYFPFQKDKNSLSFGEE*R GA*ASAPWPSAWTACSSPPPATLRPCTSSNSRL *KKNPQRSPPPGPGTSGKCSWPPPATCLPK*QK CSTRAEPSPRSACHSAATKTSAR*PQFRRSRGCW WVPPTGTCTCTTWTPRRAASVP**SSTGWTAVW KRPMRSWTLPLTTAP*SLRHTAQLQEKPTQTTW VLWVAPAWRTRPAPCAWMRTASTRP*FFGLTELD L*PLTRGAENTGFTEDFVHCCYEL*PESGERMA ETLLKKKKDCSGSLTP*R*GNTSFSLQWLLNPA YEF*LFVCLFSLFAKINCLVKPAKPPRFACMNVP SQHRGARSHFPATCRWVFSYLYIMPSA*GNRGV AHSGSACQGQFCSDRPRGCPPGVLGRLQLGQKS DLPRAPPGPFSLRFILLIKFFPNWIALGFLPWWT FVSDLVFPVDIGGQRGSF*Y*KPFFQAANELER LPGLAGAKESDFVCIIK*SVLLLHSSC*KTV*F FFFFK*SL*LLPCPGKHRTQVWWPSELSFRWPRC PQGLPTCVRGRSGRQQQRVGGWATSFTGRHVPF YFHLRKFPQQTDERLWLQASVFASLPFPFHIYR IKTTSSTSDSAFQTKAPSSQSVEGI*VALMAGEM VLESMEWWKLRIEGKRQKLFTLPLQAGVFEPRK AGTPVSRWLSWSRWAKSWRGVVPSAERLR*NAP VFLGWLYGKLNAGDAGVRLTYTGFLPAAGVRHTQ HLH*AEVQVG*LNFSFKTCLSVLDL**NGIPVT QAETVGTAEARVGYA*AGMRRAAAARSLDPRLR LVVQGQRALSRT*PCTPSPGSHFWQE*VWGEKVC TRDTEP*ARVSCHQRVSCISSSALKYRLFWCLP VVVIWRLKFPLPGLFCLSLGLVV*KMLGIVFLA QPRLPAL*DEAVAEEASDVL*PSAHTPPWVALAG LARCVPCRPREALCLPGSGLSCAP*RREEDCRF LVEKNEEDFCVC*AAIVEGYPPPLSRCPFHCHQ LLFLCSNL*VPASLAASDMLRSDGDRGRPLSCPL ELLLLRQ*PRWRGTLNQTERVLIFRTPNCTLIF IFKLYFSKLQKGR*AWGIGNKTCKRCEWAQWTL GPNLL*SLKQWDQELDGTWSQKELLQSPLYRLPS CGSRQGAWEPAFSGPFHGTHPYLTGLL*GVV*L RVLQTPSSVPSQRWAPNKRYNINVSSAIKHDFY S

Frame 2

ASRGRGRAGVPGAPALEHKQERGRDEAAVDPRV ASGGDRGGERGPAPTLSAA*PALARAPSPAGPT RRAPSHEPGEPERGGRRRPAALRQLQPGQHVPS CW**VRL*IFLPFFCG*AGTDL*MHRYGRCVHCR EIVLQQPSGHRQP*STKEAKGLPL*EGN*DLQL QLLQHDSGCEAQQAEADSMPGGVPVHPQHSGHE GAAYDQGDASKPCRPVCAVNQQRQLLLGVPRERD HRRGAGLRYH*FESCKHDSGSRQSFSGTGL*RK WN*TCHGFGEGDRD*GIFHSRRTKTL*VSERSK EVREHLLPGLQHGRHVPLRLQQH*DRAHLQTRDC ERKTPRGAHHLDRVLRESAHGLHQLPAFPSDRN VQPGQSLRHGPPAILRPQKHLLASHNSEDPAVV GGCRRRVPVHVQPGPPGGRRVCPDEAAPAGRQSG NDQ*DLGLCLSRLPLSHSDIRRSCRKSLHRRPG CCGWRLPGGRGQRPAPG*GQRAPAHDSSD*LNL TCDL*PGEQRTLASQRTLCIAAMNFDLSRGRGWQ RLY*KKKKIVVVV*LHNAEEIHHFHFSGF*ILL MNFSFLFVCFLFLPKLTVW*SPQNLLALHA*TC QASIGELEATFQPPAVGFFHICT*CRVRKETVAS RTVGLLVKASSAVTGPGAAHQVCWADFSWDRSP ISLGPHLDHFPSVLFC*LNSFQIGSLWDFFHGG LLFLILFSLWILEDSEVLSDTKNLSFRQQMNLKG CLDSLEQRKAILFV*LNDLFFYFTLPVEKLCDF FFFLSKVCSSSHAQESTELKCGGRLSCPFAGPA VRRGFLPV*EVVAGDSNRE*AAGPRPSQGVMCLS IFILENFLSKPMRDCGCKLQYLPRFPSLFIFTE LKQPQVPQTLHSKPRHPAAKVSRAFKWH*WQER WF*NLWSGGSYG*KGKGKNYLPCLCRLGFLNRGR LGRLFPDGCHGHAGRRAGGELSPQLSGCGEMPQ CSWVGFTAN*MQGTLESDSPTPASSQPLVCGTH NICIRQRCKWAD*TFPSKPACLSWTFDEMGSRSR RLRQWGPPRPEWAMLEQG*EGPRQHAALTHACV LWCKARGLSLEPDRALHLLGATFGKSECGGKKC AQEIRNPELGFPVTKE*AAFPVLR*SIVCSGACL WW*FGDSNFLCQVSFVFLWDW*YRRCWELSSSL SLGFPHCKMRQLQRRPRTSCDPRPTLPLGWPWQ GWLGAFPADHGKPCACLGQG*AVRPRGGRRTADS WSRRMKRISVFAEQPLWRVTRLHFPVAHFTATS SSSSARTYESQPHWRPQTCSGVTGTEGGR*VAR *NSYCCASDPGGEGP*TKQNVC*FSELQTVHSYS FLNCIFPNFKKDDERGG*ETKPVNVVNGLSGLW DQTFCNL*NNGTKSWMEPGVKKNCFSPRCTACL AVGAGRAPGSLRFLDRSMGLIPTSQGCCEVLCDC VSCKRPARCPASGGHPINATT*MCLLQLNTIFI

Sequence NM_001033518

GTGCGTCGCGGGGGCGGGGCCGCGCAGGCGTACCGGGTGCCCCGGCTCTGGAGCATAAACAAGAGCGGGGACGGGATGAGGCGGCGGTTGATCCCAGGGT GGCGAGTGGCGGCGACCGAGGCGGCGAGCGGGGCCCGGCGCCGACCCTGAGTGCAGCCTGACCCGCCCTCGCGCGCGCGCCCTCCCCGGCCGGGCCCACT CGCCGCGCGCCCAGCCATGAACCTGGCGAGCCAGAGCGGGGAGGCCGGCGCCGGCCAGCTGCTCTTCGCCAACTTCAACCAGGACAACACAGAAGTGAAA GGGGCATCAAGAGCAGCTGGTCTTGGCCGTCGCGCTGTTGTCTGGTCCCTAGCTGTTGGTAGTAAGTCCGGTTATAAATTTTTCTCCCTTTCTTCTGTGG ATAAGCTGGAACAGATCTATGAATGCACCGATACGGAAGATGTGTGCATTGTAGAGAGATTGTTCTCCAGCAGCCTAGTGGCCATCGTCAGCCTTAAAGC ACCAAGGAAGCTAAAGGTTTGCCACTTTAAGAAGGGAACTGAGATCTGCAACTACAGCTACTCCAACACGATTCTGGCTGTGAAGCTCAACAGGCAGAGG CTGATAGTATGCCTGGAGGAGTCCCTGTACATCCACAACATTCGGGACATGAAGGTGCTGCATACGATCAGGGAGACGCCTCCAAACCCTGCAGGCCTGT GTGCGCTGTCAATCAACAACGACAACTGCTACTTGGCGTACCCAGGGAGCGCGACCATCGGAGAGGTGCAGGTCTTCGATACCATTAATTTGAGAGCTGC AAACATGATTCCGGCTCACGACAGTCCTTTAGCGGCACTGGCCTTTGACGCAAGTGGAACTAAACTTGCCACGGCTTCGGAGAAGGGGACCGTGATTAGG GTATTTTCCATTCCAGAAGGACAAAAACTCTTTGAGTTTCGGAGAGGAGTAAAGAGGTGCGTGAGCATCTGCTCCCTGGCCTTCAGCATGGACGGCATGT TCCTCTCCGCCTCCAGCAACACTGAGACCGTGCACATCTTCAAACTCGAGACTGTGAAAGAAAAACCCCCAGAGGAGCCCACCACCTGGACCGGGTACTT CGGGAAAGTGCTCATGGCCTCCACCAGCTACCTGCCTTCCCAAGTGACAGAAATGTTCAACCAGGGCAGAGCCTTCGCCACGGTCCGCCTGCCATTCTGC GGCCACAAAAACATCTGCTCGCTAGCCACAATTCAGAAGATCCCGCGGTTGTTGGTGGGTGCCGCCGACGGGTACCTGTACATGTACAACCTGGACCCCC AGGAGGGCGGCGAGTGTGCCCTGATGAAGCAGCACCGGCTGGACGGCAGTCTGGAAACGACCAATGAGATCTTGGACTCTGCCTCTCACGACTGCCCCTT AGTCACTCAGACATACGGCGCAGCTGCAGGAAAAGCCTACACAGACGACCTGGGTGCTGTGGGTGGCGCCTGCCTGGAGGACGAGGCCAGCGCCCTGCGC CTGGATGAGGACAGCGAGCACCCGCCCATGATTCTTCGGACTGACTGAACTTGACCTGTGACCTCTGACCCGGGGAGCAGAGAACACTGGCTTCACAGAG GACTTTGTGCATTGCTGCTATGAACTTTGACCTGAGTCGGGGGAGAGGATGGCAGAGACTTTATTAAAAAAAAAAAAAGATTGTAGTGGTAGTCTAACTC CATAACGCTGAGGAAATACATCATTTTCACTTCAGTGGCTTTTAAATCCTGCTTATGAATTTTAGCTTTTTGTTTGTTTGTTTTCTCTTTTTGCCAAAAT TAACTGTTTGGTGAAGCCCGCAAAACCTCCTCGCTTTGCATGCATGAACGTGCCAAGCCAGCATAGGGGAGCTAGAAGCCACTTTCCAGCCACCTGCCGT TGGGTTTTTTCATATCTGTACATAATGCCGAGTGCGTAAGGAAACCGTGGCGTCGCGCACAGTGGGTCTGCTTGTCAAGGCCAGTTCTGCAGTGACAGGC CCAGGGGCTGCCCACCAGGTGTGCTGGGCAGACTTCAGCTGGGACAGAAGTCCGATCTCCCTAGGGCCCCACCTGGACCATTTTCCCTCCGTTTTATTTT GTTAATTAAATTCTTTCCAAATTGGATCGCTCTGGGATTTCTTCCATGGTGGACTTTTGTTTCTGATCTTGTTTTCCCTGTGGATATTGGAGGACAGCGA GGTTCTTTCTGATACTAAAAACCTTTCTTTCAGGCAGCAAATGAACTTGAAAGGTTGCCTGGACTCGCTGGAGCAAAGGAAAGCGATTTTGTTTGTATAA TTAAATGATCTGTTCTTCTACTTCACTCTTCCTGTTGAAAAACTGTGTGATTTTTTTTTTTTTTTAAGTAAAGTTTGTAGCTCCTCCCATGCCCAGGAAA GCACAGAACTCAAGTGTGGTGGCCGTCTGAGCTGTCCTTTCGCTGGCCCCGCTGTCCGCAGGGGCTTCCTACCTGTGTGAGAGGTCGTAGCGGGAGACAG CAACAGAGAGTAGGCGGCTGGGCCACGTCCTTCACAGGGCGTCATGTGCCTTTCTATTTTCATCTTAGAAAATTTCCTCAGCAAACCGATGAGAGATTGT GGTTGCAAGCTTCAGTATTTGCCTCGCTTCCCTTCCCTTTTCATATTTACAGAATTAAAACAACCTCAAGTACCTCAGACTCTGCATTCCAAACCAAGGC ACCCAGCAGCCAAAGTGTCGAGGGCATTTAAGTGGCATTAATGGCAGGAGAGATGGTTTTAGAATCTATGGAGTGGTGGAAGTTACGGATAGAAGGGAAA AGGCAAAAACTATTTACCCTGCCTTTGCAGGCTGGGGTTTTTGAACCGAGGAAGGCTGGGACGCCTGTTTCCAGATGGTTGTCATGGTCACGCTGGGCGA AGAGCTGGAGGGGAGTTGTCCCCTCAGCTGAGCGGCTGCGGTGAAATGCCCCAGTGTTCCTGGGTTGGCTTTACGGCAAACTAAATGCAGGGGACGCTGG AGTCCGACTCACCTACACCGGCTTCCTCCCAGCCGCTGGTGTGCGGCACACACAACATCTGCATTAGGCAGAGGTGCAAGTGGGCTGATTGAACTTTTCC TTCAAAACCTGCTTGTCTGTCCTGGACCTTTGATGAAATGGGATCCCGGTCACGCAGGCTGAGACAGTGGGGACCGCCGAGGCCAGAGTGGGCTATGCTT GAGCAGGGATGAGAAGGGCCGCGGCAGCACGCAGCCTTGACCCACGCCTGCGTCTTGTGGTGCAAGGCCAGAGGGCTCTCTCTAGAACCTGACCGTGCAC TCCATCTCCTGGGAGCCACTTTTGGCAAGAGTGAGTGTGGGGGGAAAAAGTGTGCACAAGAGATACGGAACCCTGAGCTAGGGTTTCCTGTCACCAAAGA GTGAGCTGCATTTCCAGTTCTGCGTTAAAGTATCGTTTGTTCTGGTGCCTGCCTGTGGTGGTGATTTGGAGACTCAAATTTCCTTTGCCAGGTCTCTTTT GTCTTTCTTTGGGATTGGTAGTATAGAAGATGCTGGGAATTGTCTTCCTCGCTCAGCCTCGGCTTCCCGCACTGTAAGATGAGGCAGTTGCAGAGGAGGC CTCGGACGTCCTGTGACCCTCGGCCCACACTCCCCCTTGGGTGGCCCTGGCAGGGCTGGCTAGGTGCGTTCCCTGCAGACCACGGGAAGCCCTGTGCTTG CCTGGGTCAGGGCTAAGCTGTGCGCCCTAGAGGAGGGAGGAGGACTGCAGATTCTTGGTCGAGAAGAATGAAGAGGATTTCTGTGTTTGCTGAGCAGCCA TTGTGGAGGGTTACCCGCCTCCACTTTCCCGTTGCCCATTTCACTGCCACCAGCTCCTCTTCCTCTGCTCGAACCTATGAGTCCCAGCCTCACTGGCGGC CTCAGACATGCTCAGGAGTGACGGGGACAGAGGGAGGCCGCTGAGTTGCCCGTTAGAACTCTTACTGCTGCGCCAGTGACCCAGGTGGAGAGGGACCCTG AACCAAACAGAACGTGTGCTAATTTTCCGAACTCCAAACTGTACACTCATATTCATTTTTAAATTGTATTTTTCCAAACTTCAAAAAGGACGATGAGCGT GGGGGATAGGAAACAAAACCTGTAAACGTTGTGAATGGGCTCAGTGGACTCTGGGACCAAACCTTCTGTAATCTCTAAAACAATGGGACCAAGAGCTGGA TGGAACCTGGAGTCAAAAAGAACTGCTTCAGTCCCCGCTGTACCGCCTGCCTAGCTGTGGGAGCAGGCAGGGCGCCTGGGAGCCTGCGTTTTCTGGACCG TTCCATGGGACTCATCCCTACCTCACAGGGCTGTTGTGAGGTGTTGTGTGACTGCGTGTCCTGCAAACGCCCAGCTCGGTGCCCAGCCAGCGGTGGGCAC CCAATAAACGCTACAACATAAATGTGTCTTCTGCAATTAAACACGATTTTTATTCA

refseq_WIPI2.F1 (forward primer)
refseq_WIPI2.R1 (reverse primer)
Single exon skipping

Frame 0

VRRGGGAAQAYRVPRLWSINKSGDGMRRRLIPG WRVAATEAASGARRRP*VQPDPPSRARPPRPGPL AARPAMNLASQSGEAGAGQLLFANFNQDNTEVK GASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSV DKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKA PRKLKVCHFKKGTEICNYSYSNTILAVKLNRQR LIVCLEESLYIHNIRDMKVLHTIRETPPNPAGL CALSINNDNCYLAYPGSATIGEVQVFDTINLRAA NMIPAHDSPLAALAFDASGTKLATASEKGTVIR VFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM FLSASSNTETVHIFKLETVKEKPPEEPTTWTGYF GKVLMASTSYLPSQVTEMFNQGRAFATVRLPFC GHKNICSLATIQKIPRLLVGAADGYLYMYNLDP QEGGECALMKQHRLDGSLETTNEILDSASHDCPL VTQTYGAAAGKAYTDDLGAVGGACLEDEASALR LDEDSEHPPMILRTD*T*PVTSDPGSREHWLHR GLCALLL*TLT*VGGEDGRDFIKKKKRL*W*SNS ITLRKYIIFTSVAFKSCL*ILAFCLFVFSFCQN *LFGEARKTSSLCMHERAKPA*GS*KPLSSHLP LGFFISVHNAECVRKPWRRAQWVCLSRPVLQ*QA QGLPTRCAGQTSAGTEVRSP*GPTWTIFPPFYF VN*ILSKLDRSGISSMVDFCF*SCFPCGYWRTA RFFLILKTFLSGSK*T*KVAWTRWSKGKRFCLYN *MICSSTSLFLLKNCVIFFFF*VKFVAPPMPRK AQNSSVVAV*AVLSLAPLSAGASYLCERS*RET ATESRRLGHVLHRASCAFLFSS*KISSANR*EIV VASFSICLASLPFSYLQN*NNLKYLRLCIPNQG TQQPKCRGHLSGINGRRDGFRIYGVVEVTDRRE KAKTIYPAFAGWGF*TEEGWDACFQMVVMVTLGE ELEGSCPLS*AAAVKCPSVPGLALRQTKCRGRW SPTHLHRLPPSRWCAAHTTSALGRGASGLIELF LQNLLVCPGPLMKWDPGHAG*DSGDRRGQSGLCL SRDEKGRGSTQP*PTPASCGARPEGSL*NLTVH SISWEPLLARVSVGGKSVHKRYGTLS*GFLSPK SELHFQFCVKVSFVLVPACGGDLETQISFARSLL SFFGIGSIEDAGNCLPRSASASRTVR*GSCRGG LGRPVTLGPHSPLGGPGRAG*VRSLQTTGSPVL AWVRAKLCALEEGGGLQILGREE*RGFLCLLSSH CGGLPASTFPLPISLPPAPLPLLEPMSPSLTGG LRHAQE*RGQREAAELPVRTLTAAPVTQVERDP EPNRTCANFPNSKLYTHIHF*IVFFQTSKRTMSV GDRKQNL*TL*MGSVDSGTKPSVISKTMGPRAG WNLESKRTASVPAVPPA*LWEQAGRLGACVFWT VPWDSSLPHRAVVRCCVTACPANAQLGAQPAVGT Q*TLQHKCVFCN*TRFLF

Frame 1

CVAGAGPRRRTGCPGSGA*TRAGTG*GGG*SQG GEWRRPRRRAGPGADPECSLTRPRARALPGRAH SPRAQP*TWRARAGRPAPASCSSPTSTRTTQK*K GHQEQLVLAVALLSGP*LLVVSPVINFSPFLLW ISWNRSMNAPIRKMCAL*RDCSPAA*WPSSALK HQGS*RFATLRRELRSATTATPTRFWL*SSTGRG **YAWRSPCTSTTFGT*RCCIRSGRRLQTLQAC VRCQSTTTTATWRTQGARPSERCRSSIPLI*EL QT*FRLTTVL*RHWPLTQVELNLPRLRRRGP*LG YFPFQKDKNSLSFGEE*RGA*ASAPWPSAWTAC SSPPPATLRPCTSSNSRL*KKNPQRSPPPGPGT SGKCSWPPPATCLPK*QKCSTRAEPSPRSACHSA ATKTSAR*PQFRRSRGCWWVPPTGTCTCTTWTP RRAASVP**SSTGWTAVWKRPMRSWTLPLTTAP *SLRHTAQLQEKPTQTTWVLWVAPAWRTRPAPCA WMRTASTRP*FFGLTELDL*PLTRGAENTGFTE DFVHCCYEL*PESGERMAETLLKKKKDCSGSLT P*R*GNTSFSLQWLLNPAYEF*LFVCLFSLFAKI NCLVKPAKPPRFACMNVPSQHRGARSHFPATCR WVFSYLYIMPSA*GNRGVAHSGSACQGQFCSDR PRGCPPGVLGRLQLGQKSDLPRAPPGPFSLRFIL LIKFFPNWIALGFLPWWTFVSDLVFPVDIGGQR GSF*Y*KPFFQAANELERLPGLAGAKESDFVCI IK*SVLLLHSSC*KTV*FFFFFK*SL*LLPCPGK HRTQVWWPSELSFRWPRCPQGLPTCVRGRSGRQ QQRVGGWATSFTGRHVPFYFHLRKFPQQTDERL WLQASVFASLPFPFHIYRIKTTSSTSDSAFQTKA PSSQSVEGI*VALMAGEMVLESMEWWKLRIEGK RQKLFTLPLQAGVFEPRKAGTPVSRWLSWSRWA KSWRGVVPSAERLR*NAPVFLGWLYGKLNAGDAG VRLTYTGFLPAAGVRHTQHLH*AEVQVG*LNFS FKTCLSVLDL**NGIPVTQAETVGTAEARVGYA *AGMRRAAAARSLDPRLRLVVQGQRALSRT*PCT PSPGSHFWQE*VWGEKVCTRDTEP*ARVSCHQR VSCISSSALKYRLFWCLPVVVIWRLKFPLPGLF CLSLGLVV*KMLGIVFLAQPRLPAL*DEAVAEEA SDVL*PSAHTPPWVALAGLARCVPCRPREALCL PGSGLSCAP*RREEDCRFLVEKNEEDFCVC*AA IVEGYPPPLSRCPFHCHQLLFLCSNL*VPASLAA SDMLRSDGDRGRPLSCPLELLLLRQ*PRWRGTL NQTERVLIFRTPNCTLIFIFKLYFSKLQKGR*A WGIGNKTCKRCEWAQWTLGPNLL*SLKQWDQELD GTWSQKELLQSPLYRLPSCGSRQGAWEPAFSGP FHGTHPYLTGLL*GVV*LRVLQTPSSVPSQRWA PNKRYNINVSSAIKHDFYS

Frame 2

ASRGRGRAGVPGAPALEHKQERGRDEAAVDPRV ASGGDRGGERGPAPTLSAA*PALARAPSPAGPT RRAPSHEPGEPERGGRRRPAALRQLQPGQHRSE RGIKSSWSWPSRCCLVPSCW**VRL*IFLPFFCG *AGTDL*MHRYGRCVHCREIVLQQPSGHRQP*S TKEAKGLPL*EGN*DLQLQLLQHDSGCEAQQAE ADSMPGGVPVHPQHSGHEGAAYDQGDASKPCRPV CAVNQQRQLLLGVPRERDHRRGAGLRYH*FESC KHDSGSRQSFSGTGL*RKWN*TCHGFGEGDRD* GIFHSRRTKTL*VSERSKEVREHLLPGLQHGRHV PLRLQQH*DRAHLQTRDCERKTPRGAHHLDRVL RESAHGLHQLPAFPSDRNVQPGQSLRHGPPAIL RPQKHLLASHNSEDPAVVGGCRRRVPVHVQPGPP GGRRVCPDEAAPAGRQSGNDQ*DLGLCLSRLPL SHSDIRRSCRKSLHRRPGCCGWRLPGGRGQRPA PG*GQRAPAHDSSD*LNLTCDL*PGEQRTLASQR TLCIAAMNFDLSRGRGWQRLY*KKKKIVVVV*L HNAEEIHHFHFSGF*ILLMNFSFLFVCFLFLPK LTVW*SPQNLLALHA*TCQASIGELEATFQPPAV GFFHICT*CRVRKETVASRTVGLLVKASSAVTG PGAAHQVCWADFSWDRSPISLGPHLDHFPSVLF C*LNSFQIGSLWDFFHGGLLFLILFSLWILEDSE VLSDTKNLSFRQQMNLKGCLDSLEQRKAILFV* LNDLFFYFTLPVEKLCDFFFFLSKVCSSSHAQE STELKCGGRLSCPFAGPAVRRGFLPV*EVVAGDS NRE*AAGPRPSQGVMCLSIFILENFLSKPMRDC GCKLQYLPRFPSLFIFTELKQPQVPQTLHSKPR HPAAKVSRAFKWH*WQERWF*NLWSGGSYG*KGK GKNYLPCLCRLGFLNRGRLGRLFPDGCHGHAGR RAGGELSPQLSGCGEMPQCSWVGFTAN*MQGTL ESDSPTPASSQPLVCGTHNICIRQRCKWAD*TFP SKPACLSWTFDEMGSRSRRLRQWGPPRPEWAML EQG*EGPRQHAALTHACVLWCKARGLSLEPDRA LHLLGATFGKSECGGKKCAQEIRNPELGFPVTKE *AAFPVLR*SIVCSGACLWW*FGDSNFLCQVSF VFLWDW*YRRCWELSSSLSLGFPHCKMRQLQRR PRTSCDPRPTLPLGWPWQGWLGAFPADHGKPCAC LGQG*AVRPRGGRRTADSWSRRMKRISVFAEQP LWRVTRLHFPVAHFTATSSSSSARTYESQPHWR PQTCSGVTGTEGGR*VAR*NSYCCASDPGGEGP* TKQNVC*FSELQTVHSYSFLNCIFPNFKKDDER GG*ETKPVNVVNGLSGLWDQTFCNL*NNGTKSW MEPGVKKNCFSPRCTACLAVGAGRAPGSLRFLDR SMGLIPTSQGCCEVLCDCVSCKRPARCPASGGH PINATT*MCLLQLNTIFI

Sequence NM_015610

GTGCGTCGCGGGGGCGGGGCCGCGCAGGCGTACCGGGTGCCCCGGCTCTGGAGCATAAACAAGAGCGGGGACGGGATGAGGCGGCGGTTGATCCCAGGGT GGCGAGTGGCGGCGACCGAGGCGGCGAGCGGGGCCCGGCGCCGACCCTGAGTGCAGCCTGACCCGCCCTCGCGCGCGCGCCCTCCCCGGCCGGGCCCACT CGCCGCGCGCCCAGCCATGAACCTGGCGAGCCAGAGCGGGGAGGCCGGCGCCGGCCAGCTGCTCTTCGCCAACTTCAACCAGGACAACACAGAAGTGAAA GGGGCATCAAGAGCAGCTGGTCTTGGCCGTCGCGCTGTTGTCTGGTCCCTAGCTGTTGGTAGTAAGTCCGGTTATAAATTTTTCTCCCTTTCTTCTGTGG ATAAGCTGGAACAGATCTATGAATGCACCGATACGGAAGATGTGTGCATTGTAGAGAGATTGTTCTCCAGCAGCCTAGTGGCCATCGTCAGCCTTAAAGC ACCAAGGAAGCTAAAGGTTTGCCACTTTAAGAAGGGAACTGAGATCTGCAACTACAGCTACTCCAACACGATTCTGGCTGTGAAGCTCAACAGGCAGAGG CTGATAGTATGCCTGGAGGAGTCCCTGTACATCCACAACATTCGGGACATGAAGGTGCTGCATACGATCAGGGAGACGCCTCCAAACCCTGCAGGCCTGT GTGCGCTGTCAATCAACAACGACAACTGCTACTTGGCGTACCCAGGGAGCGCGACCATCGGAGAGGTGCAGGTCTTCGATACCATTAATTTGAGAGCTGC AAACATGATTCCGGCTCACGACAGTCCTTTAGCGGCACTGGCCTTTGACGCAAGTGGAACTAAACTTGCCACGGCTTCGGAGAAGGGGACCGTGATTAGG GTATTTTCCATTCCAGAAGGACAAAAACTCTTTGAGTTTCGGAGAGGAGTAAAGAGGTGCGTGAGCATCTGCTCCCTGGCCTTCAGCATGGACGGCATGT TCCTCTCCGCCTCCAGCAACACTGAGACCGTGCACATCTTCAAACTCGAGACTGTGAAAGAAAAACCCCCAGAGGAGCCCACCACCTGGACCGGGTACTT CGGGAAAGTGCTCATGGCCTCCACCAGCTACCTGCCTTCCCAAGTGACAGAAATGTTCAACCAGGGCAGAGCCTTCGCCACGGTCCGCCTGCCATTCTGC GGCCACAAAAACATCTGCTCGCTAGCCACAATTCAGAAGATCCCGCGGTTGTTGGTGGGTGCCGCCGACGGGTACCTGTACATGTACAACCTGGACCCCC AGGAGGGCGGCGAGTGTGCCCTGATGAAGCAGCACCGGCTGGACGGCAGTCTGGAAACGACCAATGAGATCTTGGACTCTGCCTCTCACGACTGCCCCTT AGTCACTCAGACATACGGCGCAGCTGCAGGAAAAGGTACTTACGTGCCTTCATCCCCAACGAGACTTGCCTACACAGACGACCTGGGTGCTGTGGGTGGC GCCTGCCTGGAGGACGAGGCCAGCGCCCTGCGCCTGGATGAGGACAGCGAGCACCCGCCCATGATTCTTCGGACTGACTGAACTTGACCTGTGACCTCTG ACCCGGGGAGCAGAGAACACTGGCTTCACAGAGGACTTTGTGCATTGCTGCTATGAACTTTGACCTGAGTCGGGGGAGAGGATGGCAGAGACTTTATTAA AAAAAAAAAAAGATTGTAGTGGTAGTCTAACTCCATAACGCTGAGGAAATACATCATTTTCACTTCAGTGGCTTTTAAATCCTGCTTATGAATTTTAGCT TTTTGTTTGTTTGTTTTCTCTTTTTGCCAAAATTAACTGTTTGGTGAAGCCCGCAAAACCTCCTCGCTTTGCATGCATGAACGTGCCAAGCCAGCATAGG GGAGCTAGAAGCCACTTTCCAGCCACCTGCCGTTGGGTTTTTTCATATCTGTACATAATGCCGAGTGCGTAAGGAAACCGTGGCGTCGCGCACAGTGGGT CTGCTTGTCAAGGCCAGTTCTGCAGTGACAGGCCCAGGGGCTGCCCACCAGGTGTGCTGGGCAGACTTCAGCTGGGACAGAAGTCCGATCTCCCTAGGGC CCCACCTGGACCATTTTCCCTCCGTTTTATTTTGTTAATTAAATTCTTTCCAAATTGGATCGCTCTGGGATTTCTTCCATGGTGGACTTTTGTTTCTGAT CTTGTTTTCCCTGTGGATATTGGAGGACAGCGAGGTTCTTTCTGATACTAAAAACCTTTCTTTCAGGCAGCAAATGAACTTGAAAGGTTGCCTGGACTCG CTGGAGCAAAGGAAAGCGATTTTGTTTGTATAATTAAATGATCTGTTCTTCTACTTCACTCTTCCTGTTGAAAAACTGTGTGATTTTTTTTTTTTTTTAA GTAAAGTTTGTAGCTCCTCCCATGCCCAGGAAAGCACAGAACTCAAGTGTGGTGGCCGTCTGAGCTGTCCTTTCGCTGGCCCCGCTGTCCGCAGGGGCTT CCTACCTGTGTGAGAGGTCGTAGCGGGAGACAGCAACAGAGAGTAGGCGGCTGGGCCACGTCCTTCACAGGGCGTCATGTGCCTTTCTATTTTCATCTTA GAAAATTTCCTCAGCAAACCGATGAGAGATTGTGGTTGCAAGCTTCAGTATTTGCCTCGCTTCCCTTCCCTTTTCATATTTACAGAATTAAAACAACCTC AAGTACCTCAGACTCTGCATTCCAAACCAAGGCACCCAGCAGCCAAAGTGTCGAGGGCATTTAAGTGGCATTAATGGCAGGAGAGATGGTTTTAGAATCT ATGGAGTGGTGGAAGTTACGGATAGAAGGGAAAAGGCAAAAACTATTTACCCTGCCTTTGCAGGCTGGGGTTTTTGAACCGAGGAAGGCTGGGACGCCTG TTTCCAGATGGTTGTCATGGTCACGCTGGGCGAAGAGCTGGAGGGGAGTTGTCCCCTCAGCTGAGCGGCTGCGGTGAAATGCCCCAGTGTTCCTGGGTTG GCTTTACGGCAAACTAAATGCAGGGGACGCTGGAGTCCGACTCACCTACACCGGCTTCCTCCCAGCCGCTGGTGTGCGGCACACACAACATCTGCATTAG GCAGAGGTGCAAGTGGGCTGATTGAACTTTTCCTTCAAAACCTGCTTGTCTGTCCTGGACCTTTGATGAAATGGGATCCCGGTCACGCAGGCTGAGACAG TGGGGACCGCCGAGGCCAGAGTGGGCTATGCTTGAGCAGGGATGAGAAGGGCCGCGGCAGCACGCAGCCTTGACCCACGCCTGCGTCTTGTGGTGCAAGG CCAGAGGGCTCTCTCTAGAACCTGACCGTGCACTCCATCTCCTGGGAGCCACTTTTGGCAAGAGTGAGTGTGGGGGGAAAAAGTGTGCACAAGAGATACG GAACCCTGAGCTAGGGTTTCCTGTCACCAAAGAGTGAGCTGCATTTCCAGTTCTGCGTTAAAGTATCGTTTGTTCTGGTGCCTGCCTGTGGTGGTGATTT GGAGACTCAAATTTCCTTTGCCAGGTCTCTTTTGTCTTTCTTTGGGATTGGTAGTATAGAAGATGCTGGGAATTGTCTTCCTCGCTCAGCCTCGGCTTCC CGCACTGTAAGATGAGGCAGTTGCAGAGGAGGCCTCGGACGTCCTGTGACCCTCGGCCCACACTCCCCCTTGGGTGGCCCTGGCAGGGCTGGCTAGGTGC GTTCCCTGCAGACCACGGGAAGCCCTGTGCTTGCCTGGGTCAGGGCTAAGCTGTGCGCCCTAGAGGAGGGAGGAGGACTGCAGATTCTTGGTCGAGAAGA ATGAAGAGGATTTCTGTGTTTGCTGAGCAGCCATTGTGGAGGGTTACCCGCCTCCACTTTCCCGTTGCCCATTTCACTGCCACCAGCTCCTCTTCCTCTG CTCGAACCTATGAGTCCCAGCCTCACTGGCGGCCTCAGACATGCTCAGGAGTGACGGGGACAGAGGGAGGCCGCTGAGTTGCCCGTTAGAACTCTTACTG CTGCGCCAGTGACCCAGGTGGAGAGGGACCCTGAACCAAACAGAACGTGTGCTAATTTTCCGAACTCCAAACTGTACACTCATATTCATTTTTAAATTGT ATTTTTCCAAACTTCAAAAAGGACGATGAGCGTGGGGGATAGGAAACAAAACCTGTAAACGTTGTGAATGGGCTCAGTGGACTCTGGGACCAAACCTTCT GTAATCTCTAAAACAATGGGACCAAGAGCTGGATGGAACCTGGAGTCAAAAAGAACTGCTTCAGTCCCCGCTGTACCGCCTGCCTAGCTGTGGGAGCAGG CAGGGCGCCTGGGAGCCTGCGTTTTCTGGACCGTTCCATGGGACTCATCCCTACCTCACAGGGCTGTTGTGAGGTGTTGTGTGACTGCGTGTCCTGCAAA CGCCCAGCTCGGTGCCCAGCCAGCGGTGGGCACCCAATAAACGCTACAACATAAATGTGTCTTCTGCAATTAAACACGATTTTTATTCA

refseq_WIPI2.F1 (forward primer)
refseq_WIPI2.R1 (reverse primer)
Single exon skipping

Frame 0

VRRGGGAAQAYRVPRLWSINKSGDGMRRRLIPG WRVAATEAASGARRRP*VQPDPPSRARPPRPGPL AARPAMNLASQSGEAGAGQLLFANFNQDNTEVK GASRAAGLGRRAVVWSLAVGSKSGYKFFSLSSV DKLEQIYECTDTEDVCIVERLFSSSLVAIVSLKA PRKLKVCHFKKGTEICNYSYSNTILAVKLNRQR LIVCLEESLYIHNIRDMKVLHTIRETPPNPAGL CALSINNDNCYLAYPGSATIGEVQVFDTINLRAA NMIPAHDSPLAALAFDASGTKLATASEKGTVIR VFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGM FLSASSNTETVHIFKLETVKEKPPEEPTTWTGYF GKVLMASTSYLPSQVTEMFNQGRAFATVRLPFC GHKNICSLATIQKIPRLLVGAADGYLYMYNLDP QEGGECALMKQHRLDGSLETTNEILDSASHDCPL VTQTYGAAAGKGTYVPSSPTRLAYTDDLGAVGG ACLEDEASALRLDEDSEHPPMILRTD*T*PVTS DPGSREHWLHRGLCALLL*TLT*VGGEDGRDFIK KKKRL*W*SNSITLRKYIIFTSVAFKSCL*ILA FCLFVFSFCQN*LFGEARKTSSLCMHERAKPA* GS*KPLSSHLPLGFFISVHNAECVRKPWRRAQWV CLSRPVLQ*QAQGLPTRCAGQTSAGTEVRSP*G PTWTIFPPFYFVN*ILSKLDRSGISSMVDFCF* SCFPCGYWRTARFFLILKTFLSGSK*T*KVAWTR WSKGKRFCLYN*MICSSTSLFLLKNCVIFFFF* VKFVAPPMPRKAQNSSVVAV*AVLSLAPLSAGA SYLCERS*RETATESRRLGHVLHRASCAFLFSS* KISSANR*EIVVASFSICLASLPFSYLQN*NNL KYLRLCIPNQGTQQPKCRGHLSGINGRRDGFRI YGVVEVTDRREKAKTIYPAFAGWGF*TEEGWDAC FQMVVMVTLGEELEGSCPLS*AAAVKCPSVPGL ALRQTKCRGRWSPTHLHRLPPSRWCAAHTTSAL GRGASGLIELFLQNLLVCPGPLMKWDPGHAG*DS GDRRGQSGLCLSRDEKGRGSTQP*PTPASCGAR PEGSL*NLTVHSISWEPLLARVSVGGKSVHKRY GTLS*GFLSPKSELHFQFCVKVSFVLVPACGGDL ETQISFARSLLSFFGIGSIEDAGNCLPRSASAS RTVR*GSCRGGLGRPVTLGPHSPLGGPGRAG*V RSLQTTGSPVLAWVRAKLCALEEGGGLQILGREE *RGFLCLLSSHCGGLPASTFPLPISLPPAPLPL LEPMSPSLTGGLRHAQE*RGQREAAELPVRTLT AAPVTQVERDPEPNRTCANFPNSKLYTHIHF*IV FFQTSKRTMSVGDRKQNL*TL*MGSVDSGTKPS VISKTMGPRAGWNLESKRTASVPAVPPA*LWEQ AGRLGACVFWTVPWDSSLPHRAVVRCCVTACPAN AQLGAQPAVGTQ*TLQHKCVFCN*TRFLF

Frame 1

CVAGAGPRRRTGCPGSGA*TRAGTG*GGG*SQG GEWRRPRRRAGPGADPECSLTRPRARALPGRAH SPRAQP*TWRARAGRPAPASCSSPTSTRTTQK*K GHQEQLVLAVALLSGP*LLVVSPVINFSPFLLW ISWNRSMNAPIRKMCAL*RDCSPAA*WPSSALK HQGS*RFATLRRELRSATTATPTRFWL*SSTGRG **YAWRSPCTSTTFGT*RCCIRSGRRLQTLQAC VRCQSTTTTATWRTQGARPSERCRSSIPLI*EL QT*FRLTTVL*RHWPLTQVELNLPRLRRRGP*LG YFPFQKDKNSLSFGEE*RGA*ASAPWPSAWTAC SSPPPATLRPCTSSNSRL*KKNPQRSPPPGPGT SGKCSWPPPATCLPK*QKCSTRAEPSPRSACHSA ATKTSAR*PQFRRSRGCWWVPPTGTCTCTTWTP RRAASVP**SSTGWTAVWKRPMRSWTLPLTTAP *SLRHTAQLQEKVLTCLHPQRDLPTQTTWVLWVA PAWRTRPAPCAWMRTASTRP*FFGLTELDL*PL TRGAENTGFTEDFVHCCYEL*PESGERMAETLL KKKKDCSGSLTP*R*GNTSFSLQWLLNPAYEF*L FVCLFSLFAKINCLVKPAKPPRFACMNVPSQHR GARSHFPATCRWVFSYLYIMPSA*GNRGVAHSG SACQGQFCSDRPRGCPPGVLGRLQLGQKSDLPRA PPGPFSLRFILLIKFFPNWIALGFLPWWTFVSD LVFPVDIGGQRGSF*Y*KPFFQAANELERLPGL AGAKESDFVCIIK*SVLLLHSSC*KTV*FFFFFK *SL*LLPCPGKHRTQVWWPSELSFRWPRCPQGL PTCVRGRSGRQQQRVGGWATSFTGRHVPFYFHL RKFPQQTDERLWLQASVFASLPFPFHIYRIKTTS STSDSAFQTKAPSSQSVEGI*VALMAGEMVLES MEWWKLRIEGKRQKLFTLPLQAGVFEPRKAGTP VSRWLSWSRWAKSWRGVVPSAERLR*NAPVFLGW LYGKLNAGDAGVRLTYTGFLPAAGVRHTQHLH* AEVQVG*LNFSFKTCLSVLDL**NGIPVTQAET VGTAEARVGYA*AGMRRAAAARSLDPRLRLVVQG QRALSRT*PCTPSPGSHFWQE*VWGEKVCTRDT EP*ARVSCHQRVSCISSSALKYRLFWCLPVVVI WRLKFPLPGLFCLSLGLVV*KMLGIVFLAQPRLP AL*DEAVAEEASDVL*PSAHTPPWVALAGLARC VPCRPREALCLPGSGLSCAP*RREEDCRFLVEK NEEDFCVC*AAIVEGYPPPLSRCPFHCHQLLFLC SNL*VPASLAASDMLRSDGDRGRPLSCPLELLL LRQ*PRWRGTLNQTERVLIFRTPNCTLIFIFKL YFSKLQKGR*AWGIGNKTCKRCEWAQWTLGPNLL *SLKQWDQELDGTWSQKELLQSPLYRLPSCGSR QGAWEPAFSGPFHGTHPYLTGLL*GVV*LRVLQ TPSSVPSQRWAPNKRYNINVSSAIKHDFYS

Frame 2

ASRGRGRAGVPGAPALEHKQERGRDEAAVDPRV ASGGDRGGERGPAPTLSAA*PALARAPSPAGPT RRAPSHEPGEPERGGRRRPAALRQLQPGQHRSE RGIKSSWSWPSRCCLVPSCW**VRL*IFLPFFCG *AGTDL*MHRYGRCVHCREIVLQQPSGHRQP*S TKEAKGLPL*EGN*DLQLQLLQHDSGCEAQQAE ADSMPGGVPVHPQHSGHEGAAYDQGDASKPCRPV CAVNQQRQLLLGVPRERDHRRGAGLRYH*FESC KHDSGSRQSFSGTGL*RKWN*TCHGFGEGDRD* GIFHSRRTKTL*VSERSKEVREHLLPGLQHGRHV PLRLQQH*DRAHLQTRDCERKTPRGAHHLDRVL RESAHGLHQLPAFPSDRNVQPGQSLRHGPPAIL RPQKHLLASHNSEDPAVVGGCRRRVPVHVQPGPP GGRRVCPDEAAPAGRQSGNDQ*DLGLCLSRLPL SHSDIRRSCRKRYLRAFIPNETCLHRRPGCCGW RLPGGRGQRPAPG*GQRAPAHDSSD*LNLTCDL* PGEQRTLASQRTLCIAAMNFDLSRGRGWQRLY* KKKKIVVVV*LHNAEEIHHFHFSGF*ILLMNFS FLFVCFLFLPKLTVW*SPQNLLALHA*TCQASIG ELEATFQPPAVGFFHICT*CRVRKETVASRTVG LLVKASSAVTGPGAAHQVCWADFSWDRSPISLG PHLDHFPSVLFC*LNSFQIGSLWDFFHGGLLFLI LFSLWILEDSEVLSDTKNLSFRQQMNLKGCLDS LEQRKAILFV*LNDLFFYFTLPVEKLCDFFFFL SKVCSSSHAQESTELKCGGRLSCPFAGPAVRRGF LPV*EVVAGDSNRE*AAGPRPSQGVMCLSIFIL ENFLSKPMRDCGCKLQYLPRFPSLFIFTELKQP QVPQTLHSKPRHPAAKVSRAFKWH*WQERWF*NL WSGGSYG*KGKGKNYLPCLCRLGFLNRGRLGRL FPDGCHGHAGRRAGGELSPQLSGCGEMPQCSWV GFTAN*MQGTLESDSPTPASSQPLVCGTHNICIR QRCKWAD*TFPSKPACLSWTFDEMGSRSRRLRQ WGPPRPEWAMLEQG*EGPRQHAALTHACVLWCK ARGLSLEPDRALHLLGATFGKSECGGKKCAQEIR NPELGFPVTKE*AAFPVLR*SIVCSGACLWW*F GDSNFLCQVSFVFLWDW*YRRCWELSSSLSLGF PHCKMRQLQRRPRTSCDPRPTLPLGWPWQGWLGA FPADHGKPCACLGQG*AVRPRGGRRTADSWSRR MKRISVFAEQPLWRVTRLHFPVAHFTATSSSSS ARTYESQPHWRPQTCSGVTGTEGGR*VAR*NSYC CASDPGGEGP*TKQNVC*FSELQTVHSYSFLNC IFPNFKKDDERGG*ETKPVNVVNGLSGLWDQTF CNL*NNGTKSWMEPGVKKNCFSPRCTACLAVGAG RAPGSLRFLDRSMGLIPTSQGCCEVLCDCVSCK RPARCPASGGHPINATT*MCLLQLNTIFI