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Sequences

Sequence NM_183361

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG TCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTG CAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAA CAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCA GAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGA TGAAGTTGCTGAAGGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGG CTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAGGAAGAAGAA GAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCG AAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGA GAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTC CCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA

refseq_DTNB.F2 (forward primer)
refseq_DTNB.R2 (reverse primer)
Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA AVHRNACSEF*CHTTINLQNSLQITICTKTMQP SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH VLWSAHSHQECSGQS*PTG*GTPSYSSLCCPAGC RSRKRDSSSH*LEL*L*CQQTTKTAYCRTGKQK QRDPAGDSASPPGTRAGLPAHP*EGTAEPHAAG RAAAAEAKEG*TGAEDVGPAGEQAGADGPAGRAD EVAEGSGHRVTTYIAHPWRRPANAHASALHVCR LHPHPLSAGLAERSRGRRAGGLRTSRGRCRGRR REDAEWERQRLAEEPDTEEAQAQRTRSKLAPTWR RQGLPPEAHSSPSFHRTPGPGLQAARRHSTRQG EGSQSRWEAGRGCVAQLVGLPLHSPACTSTFIT PLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM SSGVPTPTKSVLDSPSRLDEEHRLIARYAARLA AEAGNVTRPPTDLSFNFDANKQQRQLIAELENKN REILQEIQRLRLEHEQASQPTPEKAQQNPTLLA ELRLLRQRKDELEQRMSALQESRRELMVQLEEL MKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAG STPTHCPQDSLSGVGGDVQEAFAQAEEGAEEEE EKMQNGKDRG*QRSRTQRKLRHRGRGASWRRHG EGKVFPQRHIPLHLSTAHLDQACRLPDVTPPARE RGARAGGKRGGAAWHS*WASPCTALHVLAPSSL PSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF ILLISGT*LKPSETMALIHWTIPPRSVCPASKL SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV *WVSGTDASSATTISSARIAFGVAMPAALTATS TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC PLECPLPPRVFWTVLADWMRNTVL*LAMLPGWL QKQET*LVLPLT*ALTLMPTNNKDSLLQNWKTK TERSCRRFSVSAWNTSRPPSPPLRRHSRTPRCWQ SCGC*GKGRMNWSRGCRPCRRAGGS*WSSWKS* *SC*RLRPQGHHIHRPPMEAAGQCPCQCAPRLP APPPPTVRRTR*AESGETCRRPSHKQRKVQRKKK RRCRMGKTEVSRGAGHRGSSGTEDEEQAGADMA KARSSPRGTFLSIFPPHTWTRLAGCQTSLHPPG RGEPEPVGSGEGLRGTASGPPPAQPCMY*HLHHS PQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_033148

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG TCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTG CAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAA CAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCA GAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGA TGAAGTTGCTGAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCC AGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAG GAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAG CAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGA CGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCAT GTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA

refseq_DTNB.F2 (forward primer)
refseq_DTNB.R2 (reverse primer)
Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA AVHRNACSEF*CHTTINLQNSLQITICTKTMQP SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH VLWSAHSHQECSGQS*PTG*GTPSYSSLCCPAGC RSRKRDSSSH*LEL*L*CQQTTKTAYCRTGKQK QRDPAGDSASPPGTRAGLPAHP*EGTAEPHAAG RAAAAEAKEG*TGAEDVGPAGEQAGADGPAGRAD EVAEGGRAKAGSSGHRVTTYIAHPWRRPANAHA SALHVCRLHPHPLSAGLAERSRGRRAGGLRTSR GRCRGRRREDAEWERQRLAEEPDTEEAQAQRTRS KLAPTWRRQGLPPEAHSSPSFHRTPGPGLQAAR RHSTRQGEGSQSRWEAGRGCVAQLVGLPLHSPA CTSTFITPLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM SSGVPTPTKSVLDSPSRLDEEHRLIARYAARLA AEAGNVTRPPTDLSFNFDANKQQRQLIAELENKN REILQEIQRLRLEHEQASQPTPEKAQQNPTLLA ELRLLRQRKDELEQRMSALQESRRELMVQLEEL MKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMP VRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQAE EGAEEEEEKMQNGKDRG*QRSRTQRKLRHRGRG ASWRRHGEGKVFPQRHIPLHLSTAHLDQACRLPD VTPPARERGARAGGKRGGAAWHS*WASPCTALH VLAPSSLPSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF ILLISGT*LKPSETMALIHWTIPPRSVCPASKL SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV *WVSGTDASSATTISSARIAFGVAMPAALTATS TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC PLECPLPPRVFWTVLADWMRNTVL*LAMLPGWL QKQET*LVLPLT*ALTLMPTNNKDSLLQNWKTK TERSCRRFSVSAWNTSRPPSPPLRRHSRTPRCWQ SCGC*GKGRMNWSRGCRPCRRAGGS*WSSWKS* *SC*RRKSKSRQLRPQGHHIHRPPMEAAGQCPC QCAPRLPAPPPPTVRRTR*AESGETCRRPSHKQR KVQRKKKRRCRMGKTEVSRGAGHRGSSGTEDEE QAGADMAKARSSPRGTFLSIFPPHTWTRLAGCQ TSLHPPGRGEPEPVGSGEGLRGTASGPPPAQPCM Y*HLHHSPQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_033147

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG TCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATACCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCC GTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGG AAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATC CTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGC TGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCT GAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCC ACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAG AGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCG CCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCA CCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCAC CTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA

refseq_DTNB.F2 (forward primer)
refseq_DTNB.R2 (reverse primer)
Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA AVHRNACSEF*CHTTINLQNSLQITICTKTMQP SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH VLWSAHSHQEVTV*PGYTQSLGR*ACADSLLCGP SAALCTCSGQS*PTG*GTPSYSSLCCPAGCRSR KRDSSSH*LEL*L*CQQTTKTAYCRTGKQKQRD PAGDSASPPGTRAGLPAHP*EGTAEPHAAGRAAA AEAKEG*TGAEDVGPAGEQAGADGPAGRADEVA EGGRAKAGSSGHRVTTYIAHPWRRPANAHASAL HVCRLHPHPLSAGLAERSRGRRAGGLRTSRGRCR GRRREDAEWERQRLAEEPDTEEAQAQRTRSKLA PTWRRQGLPPEAHSSPSFHRTPGPGLQAARRHS TRQGEGSQSRWEAGRGCVAQLVGLPLHSPACTST FITPLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM SSGVPTPTKRLQYSQDIPSHLADEHALIASYVA RLQHCARVLDSPSRLDEEHRLIARYAARLAAEAG NVTRPPTDLSFNFDANKQQRQLIAELENKNREI LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELR LLRQRKDELEQRMSALQESRRELMVQLEELMKLL KEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS TSAGSTPTHCPQDSLSGVGGDVQEAFAQAEEGA EEEEEKMQNGKDRG*QRSRTQRKLRHRGRGASWR RHGEGKVFPQRHIPLHLSTAHLDQACRLPDVTP PARERGARAGGKRGGAAWHS*WASPCTALHVLA PSSLPSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF ILLISGT*LKPSETMALIHWTIPPRSVCPASKL SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV *WVSGTDASSATTISSARIAFGVAMPAALTATS TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC PLECPLPPRGYSIARIYPVTWPMSMR**PPMWP VCSTVHVFWTVLADWMRNTVL*LAMLPGWLQKQ ET*LVLPLT*ALTLMPTNNKDSLLQNWKTKTERS CRRFSVSAWNTSRPPSPPLRRHSRTPRCWQSCG C*GKGRMNWSRGCRPCRRAGGS*WSSWKS**SC *RRKSKSRQLRPQGHHIHRPPMEAAGQCPCQCAP RLPAPPPPTVRRTR*AESGETCRRPSHKQRKVQ RKKKRRCRMGKTEVSRGAGHRGSSGTEDEEQAG ADMAKARSSPRGTFLSIFPPHTWTRLAGCQTSLH PPGRGEPEPVGSGEGLRGTASGPPPAQPCMY*H LHHSPQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_183360

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG TCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATACCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCC GTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGG AAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATC CTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGC TGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCT GAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCC ACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACC TCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGAGCCGGACACAGAG GAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACAC CTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGT GGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAA GAGAAAAGAAAAAGCACCAA

refseq_DTNB.F2 (forward primer)
refseq_DTNB.R2 (reverse primer)
Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA AVHRNACSEF*CHTTINLQNSLQITICTKTMQP SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH VLWSAHSHQEVTV*PGYTQSLGR*ACADSLLCGP SAALCTCSGQS*PTG*GTPSYSSLCCPAGCRSR KRDSSSH*LEL*L*CQQTTKTAYCRTGKQKQRD PAGDSASPPGTRAGLPAHP*EGTAEPHAAGRAAA AEAKEG*TGAEDVGPAGEQAGADGPAGRADEVA EGGRAKAGSSGHRVTTYIAHPWRRPANAHASAL HVCRLHPHPLSAGLAERSRGRRAGGLRTRYEEKP PQ*PAGGS*LHHQHHVIPGEGAPFRLAEEPDTE EAQAQRTRSKLAPTWRRQGLPPEAHSSPSFHRT PGPGLQAARRHSTRQGEGSQSRWEAGRGCVAQLV GLPLHSPACTSTFITPLRAWSHLRIRNSPGG*K EKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM SSGVPTPTKRLQYSQDIPSHLADEHALIASYVA RLQHCARVLDSPSRLDEEHRLIARYAARLAAEAG NVTRPPTDLSFNFDANKQQRQLIAELENKNREI LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELR LLRQRKDELEQRMSALQESRRELMVQLEELMKLL KEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS TSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRN LRNDLLVAADSITNTMSSLVKELHSG*QRSRTQR KLRHRGRGASWRRHGEGKVFPQRHIPLHLSTAH LDQACRLPDVTPPARERGARAGGKRGGAAWHS* WASPCTALHVLAPSSLPSGHGLISASGIHLEVEK RKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF ILLISGT*LKPSETMALIHWTIPPRSVCPASKL SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV *WVSGTDASSATTISSARIAFGVAMPAALTATS TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC PLECPLPPRGYSIARIYPVTWPMSMR**PPMWP VCSTVHVFWTVLADWMRNTVL*LAMLPGWLQKQ ET*LVLPLT*ALTLMPTNNKDSLLQNWKTKTERS CRRFSVSAWNTSRPPSPPLRRHSRTPRCWQSCG C*GKGRMNWSRGCRPCRRAGGS*WSSWKS**SC *RRKSKSRQLRPQGHHIHRPPMEAAGQCPCQCAP RLPAPPPPTVRRTR*AESGETCRRPSHKVRGET SAMTCWWQLTPSPTPCHPW*RSSIQVSRGAGHR GSSGTEDEEQAGADMAKARSSPRGTFLSIFPPHT WTRLAGCQTSLHPPGRGEPEPVGSGEGLRGTAS GPPPAQPCMY*HLHHSPQGMVSSPHQEFTWRLK REKKKHQ

Sequence NM_021907

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG TCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATACCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCC GTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGG AAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATC CTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGC TGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCT GAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCC ACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACC TCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGA AGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGC GAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGG AGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACT CCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA

refseq_DTNB.F2 (forward primer)
refseq_DTNB.R2 (reverse primer)
Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA AVHRNACSEF*CHTTINLQNSLQITICTKTMQP SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH VLWSAHSHQEVTV*PGYTQSLGR*ACADSLLCGP SAALCTCSGQS*PTG*GTPSYSSLCCPAGCRSR KRDSSSH*LEL*L*CQQTTKTAYCRTGKQKQRD PAGDSASPPGTRAGLPAHP*EGTAEPHAAGRAAA AEAKEG*TGAEDVGPAGEQAGADGPAGRADEVA EGGRAKAGSSGHRVTTYIAHPWRRPANAHASAL HVCRLHPHPLSAGLAERSRGRRAGGLRTRYEEKP PQ*PAGGS*LHHQHHVIPGEGAPFSRGRCRGRR REDAEWERQRLAEEPDTEEAQAQRTRSKLAPTW RRQGLPPEAHSSPSFHRTPGPGLQAARRHSTRQG EGSQSRWEAGRGCVAQLVGLPLHSPACTSTFIT PLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM SSGVPTPTKRLQYSQDIPSHLADEHALIASYVA RLQHCARVLDSPSRLDEEHRLIARYAARLAAEAG NVTRPPTDLSFNFDANKQQRQLIAELENKNREI LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELR LLRQRKDELEQRMSALQESRRELMVQLEELMKLL KEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS TSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRN LRNDLLVAADSITNTMSSLVKELHSAEEGAEEEE EKMQNGKDRG*QRSRTQRKLRHRGRGASWRRHG EGKVFPQRHIPLHLSTAHLDQACRLPDVTPPAR ERGARAGGKRGGAAWHS*WASPCTALHVLAPSSL PSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF ILLISGT*LKPSETMALIHWTIPPRSVCPASKL SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV *WVSGTDASSATTISSARIAFGVAMPAALTATS TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC PLECPLPPRGYSIARIYPVTWPMSMR**PPMWP VCSTVHVFWTVLADWMRNTVL*LAMLPGWLQKQ ET*LVLPLT*ALTLMPTNNKDSLLQNWKTKTERS CRRFSVSAWNTSRPPSPPLRRHSRTPRCWQSCG C*GKGRMNWSRGCRPCRRAGGS*WSSWKS**SC *RRKSKSRQLRPQGHHIHRPPMEAAGQCPCQCAP RLPAPPPPTVRRTR*AESGETCRRPSHKVRGET SAMTCWWQLTPSPTPCHPW*RSSIQQRKVQRKK KRRCRMGKTEVSRGAGHRGSSGTEDEEQAGADMA KARSSPRGTFLSIFPPHTWTRLAGCQTSLHPPG RGEPEPVGSGEGLRGTASGPPPAQPCMY*HLHH SPQGMVSSPHQEFTWRLKREKKKHQ