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Sequences

Sequence NM_033147

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG
CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC
CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA
GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT
CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG
TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC
TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT
GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG
GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC
TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT
ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC
ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA
TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG
TCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATACCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCC
GTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGG
AAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATC
CTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGC
TGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCT
GAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCC
ACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAG
AGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCG
CCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCA
CCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCAC
CTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA
  • refseq_DTNB.F1 (forward primer)
  • refseq_DTNB.R1 (reverse primer)
  • Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR
ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA
AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA
AVHRNACSEF*CHTTINLQNSLQITICTKTMQP
SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC
HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC
CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI
CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R
AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P
SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E
YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA
PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA
SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH
VLWSAHSHQEVTV*PGYTQSLGR*ACADSLLCGP
SAALCTCSGQS*PTG*GTPSYSSLCCPAGCRSR
KRDSSSH*LEL*L*CQQTTKTAYCRTGKQKQRD
PAGDSASPPGTRAGLPAHP*EGTAEPHAAGRAAA
AEAKEG*TGAEDVGPAGEQAGADGPAGRADEVA
EGGRAKAGSSGHRVTTYIAHPWRRPANAHASAL
HVCRLHPHPLSAGLAERSRGRRAGGLRTSRGRCR
GRRREDAEWERQRLAEEPDTEEAQAQRTRSKLA
PTWRRQGLPPEAHSSPSFHRTPGPGLQAARRHS
TRQGEGSQSRWEAGRGCVAQLVGLPLHSPACTST
FITPLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG
RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR
PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ
LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL
HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET
VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA
AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY
VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE
GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP
PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES
MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ
HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH
PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM
SSGVPTPTKRLQYSQDIPSHLADEHALIASYVA
RLQHCARVLDSPSRLDEEHRLIARYAARLAAEAG
NVTRPPTDLSFNFDANKQQRQLIAELENKNREI
LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELR
LLRQRKDELEQRMSALQESRRELMVQLEELMKLL
KEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS
TSAGSTPTHCPQDSLSGVGGDVQEAFAQAEEGA
EEEEEKMQNGKDRG*QRSRTQRKLRHRGRGASWR
RHGEGKVFPQRHIPLHLSTAHLDQACRLPDVTP
PARERGARAGGKRGGAAWHS*WASPCTALHVLA
PSSLPSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG
AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G
RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG
SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF
ILLISGT*LKPSETMALIHWTIPPRSVCPASKL
SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L
LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM
FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK
GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT
LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV
*WVSGTDASSATTISSARIAFGVAMPAALTATS
TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR
ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC
PLECPLPPRGYSIARIYPVTWPMSMR**PPMWP
VCSTVHVFWTVLADWMRNTVL*LAMLPGWLQKQ
ET*LVLPLT*ALTLMPTNNKDSLLQNWKTKTERS
CRRFSVSAWNTSRPPSPPLRRHSRTPRCWQSCG
C*GKGRMNWSRGCRPCRRAGGS*WSSWKS**SC
*RRKSKSRQLRPQGHHIHRPPMEAAGQCPCQCAP
RLPAPPPPTVRRTR*AESGETCRRPSHKQRKVQ
RKKKRRCRMGKTEVSRGAGHRGSSGTEDEEQAG
ADMAKARSSPRGTFLSIFPPHTWTRLAGCQTSLH
PPGRGEPEPVGSGEGLRGTASGPPPAQPCMY*H
LHHSPQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_183361

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG
CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC
CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA
GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT
CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG
TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC
TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT
GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG
GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC
TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT
ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC
ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA
TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG
TCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTG
CAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAA
CAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCA
GAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGA
TGAAGTTGCTGAAGGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGG
CTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAGGAAGAAGAA
GAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCG
AAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGA
GAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTC
CCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA
  • refseq_DTNB.F1 (forward primer)
  • refseq_DTNB.R1 (reverse primer)
  • Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR
ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA
AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA
AVHRNACSEF*CHTTINLQNSLQITICTKTMQP
SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC
HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC
CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI
CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R
AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P
SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E
YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA
PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA
SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH
VLWSAHSHQECSGQS*PTG*GTPSYSSLCCPAGC
RSRKRDSSSH*LEL*L*CQQTTKTAYCRTGKQK
QRDPAGDSASPPGTRAGLPAHP*EGTAEPHAAG
RAAAAEAKEG*TGAEDVGPAGEQAGADGPAGRAD
EVAEGSGHRVTTYIAHPWRRPANAHASALHVCR
LHPHPLSAGLAERSRGRRAGGLRTSRGRCRGRR
REDAEWERQRLAEEPDTEEAQAQRTRSKLAPTWR
RQGLPPEAHSSPSFHRTPGPGLQAARRHSTRQG
EGSQSRWEAGRGCVAQLVGLPLHSPACTSTFIT
PLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG
RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR
PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ
LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL
HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET
VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA
AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY
VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE
GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP
PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES
MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ
HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH
PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM
SSGVPTPTKSVLDSPSRLDEEHRLIARYAARLA
AEAGNVTRPPTDLSFNFDANKQQRQLIAELENKN
REILQEIQRLRLEHEQASQPTPEKAQQNPTLLA
ELRLLRQRKDELEQRMSALQESRRELMVQLEEL
MKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAG
STPTHCPQDSLSGVGGDVQEAFAQAEEGAEEEE
EKMQNGKDRG*QRSRTQRKLRHRGRGASWRRHG
EGKVFPQRHIPLHLSTAHLDQACRLPDVTPPARE
RGARAGGKRGGAAWHS*WASPCTALHVLAPSSL
PSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG
AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G
RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG
SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF
ILLISGT*LKPSETMALIHWTIPPRSVCPASKL
SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L
LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM
FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK
GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT
LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV
*WVSGTDASSATTISSARIAFGVAMPAALTATS
TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR
ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC
PLECPLPPRVFWTVLADWMRNTVL*LAMLPGWL
QKQET*LVLPLT*ALTLMPTNNKDSLLQNWKTK
TERSCRRFSVSAWNTSRPPSPPLRRHSRTPRCWQ
SCGC*GKGRMNWSRGCRPCRRAGGS*WSSWKS*
*SC*RLRPQGHHIHRPPMEAAGQCPCQCAPRLP
APPPPTVRRTR*AESGETCRRPSHKQRKVQRKKK
RRCRMGKTEVSRGAGHRGSSGTEDEEQAGADMA
KARSSPRGTFLSIFPPHTWTRLAGCQTSLHPPG
RGEPEPVGSGEGLRGTASGPPPAQPCMY*HLHHS
PQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_033148

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG
CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC
CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA
GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT
CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG
TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC
TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT
GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG
GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC
TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT
ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC
ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA
TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG
TCCTCTGGAGTGCCCACTCCCACCAAGAGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTG
CAGAAGCAGGAAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAA
CAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCA
GAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGA
TGAAGTTGCTGAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCC
AGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAG
GAAGGTGCAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAG
CAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGA
CGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCAT
GTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA
  • refseq_DTNB.F1 (forward primer)
  • refseq_DTNB.R1 (reverse primer)
  • Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR
ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA
AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA
AVHRNACSEF*CHTTINLQNSLQITICTKTMQP
SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC
HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC
CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI
CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R
AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P
SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E
YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA
PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA
SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH
VLWSAHSHQECSGQS*PTG*GTPSYSSLCCPAGC
RSRKRDSSSH*LEL*L*CQQTTKTAYCRTGKQK
QRDPAGDSASPPGTRAGLPAHP*EGTAEPHAAG
RAAAAEAKEG*TGAEDVGPAGEQAGADGPAGRAD
EVAEGGRAKAGSSGHRVTTYIAHPWRRPANAHA
SALHVCRLHPHPLSAGLAERSRGRRAGGLRTSR
GRCRGRRREDAEWERQRLAEEPDTEEAQAQRTRS
KLAPTWRRQGLPPEAHSSPSFHRTPGPGLQAAR
RHSTRQGEGSQSRWEAGRGCVAQLVGLPLHSPA
CTSTFITPLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG
RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR
PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ
LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL
HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET
VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA
AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY
VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE
GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP
PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES
MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ
HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH
PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM
SSGVPTPTKSVLDSPSRLDEEHRLIARYAARLA
AEAGNVTRPPTDLSFNFDANKQQRQLIAELENKN
REILQEIQRLRLEHEQASQPTPEKAQQNPTLLA
ELRLLRQRKDELEQRMSALQESRRELMVQLEEL
MKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMP
VRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQAE
EGAEEEEEKMQNGKDRG*QRSRTQRKLRHRGRG
ASWRRHGEGKVFPQRHIPLHLSTAHLDQACRLPD
VTPPARERGARAGGKRGGAAWHS*WASPCTALH
VLAPSSLPSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG
AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G
RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG
SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF
ILLISGT*LKPSETMALIHWTIPPRSVCPASKL
SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L
LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM
FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK
GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT
LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV
*WVSGTDASSATTISSARIAFGVAMPAALTATS
TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR
ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC
PLECPLPPRVFWTVLADWMRNTVL*LAMLPGWL
QKQET*LVLPLT*ALTLMPTNNKDSLLQNWKTK
TERSCRRFSVSAWNTSRPPSPPLRRHSRTPRCWQ
SCGC*GKGRMNWSRGCRPCRRAGGS*WSSWKS*
*SC*RRKSKSRQLRPQGHHIHRPPMEAAGQCPC
QCAPRLPAPPPPTVRRTR*AESGETCRRPSHKQR
KVQRKKKRRCRMGKTEVSRGAGHRGSSGTEDEE
QAGADMAKARSSPRGTFLSIFPPHTWTRLAGCQ
TSLHPPGRGEPEPVGSGEGLRGTASGPPPAQPCM
Y*HLHHSPQGMVSSPHQEFTWRLKREKKKHQ

Sequence NM_021907

GGGCGCGCGCCCGCCCATCCGCCCTCCGCCCTCCGCCCTCGCGCCCTCGCGCCGGGGGCGGGCGCTGCGCGTGCCGGGCGGAGAAGCGGCGCGAGCCGGG
CGCTGCGAACGTTCGCCGCGGGGGTGGCTCCGGGGCCTGAGTAGGCGCTGCCGCTGCCTCAGCCGAGGGGGCTGGGCCGGAGCGTGCGGAGGAGTGAGGC
CGCAGGAGACCTTCCCGACGACCCCTGCTCCGGCGGGGAAGTGAGCAAGGATGATTGAGGAAAGTGGGAACAAGCGGAAGACCATGGCAGAGAAGAGGCA
GCTGTTCATAGAAATGCGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACAAAAACGATGCAACCTT
CATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGAGATCAGTGTGTCCCGCCTCGAAACTG
TCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGAACAATCTATCAGCCTCCTCCTCAACTTTATGATTGC
TGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTATGTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATAT
GTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAGCAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAG
GGCCATCTTTTGGTTACACAGAGCACTCAGTCCGCACCTGTTTTCCACAGCAGAGAAAGATAATGCTAAATATGTTTTTAGACACAATGATGGCTGACCC
TCCTCCCCAGTGCCTTGTCTGGCTACCTCTCATGCACAGGCTTGCCCATGTTGAGAATGTCTTCCATCCCGTGGAGTGCTCCTACTGCCGATGTGAGAGT
ATGATGGGTTTCCGGTACCGATGCCAGCAGTGCCACAACTATCAGCTCTGCCAGAATTGCTTTTGGCGTGGCCATGCCGGCGGCCCTCACAGCAACCAGC
ACCAGATGAAGGAGCATTCCTCTTGGAAATCTCCTGCAAAGAAGCTGAGCCATGCAATTAGTAAATCTTTGGGGTGTGTACCCACGAGAGAACCCCCGCA
TCCTGTTTTTCCTGAGCAACCAGAGAAACCACTTGACCTTGCACATATAGTTCCTCCTCGCCCTCTGACTAATATGAATGACACCATGGTTAGCCACATG
TCCTCTGGAGTGCCCACTCCCACCAAGAGGTTACAGTATAGCCAGGATATACCCAGTCACTTGGCCGATGAGCATGCGCTGATAGCCTCCTATGTGGCCC
GTCTGCAGCACTGTGCACGTGTTCTGGACAGTCCTAGCCGACTGGATGAGGAACACCGTCTTATAGCTCGCTATGCTGCCCGGCTGGCTGCAGAAGCAGG
AAACGTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCAACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATC
CTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGCAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGC
TGCTGAGGCAAAGGAAGGATGAACTGGAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCT
GAAGGAGGAAGAGCAAAAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCC
ACGTCTGCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACC
TCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAG
CAGAGGAAGGTGCAGAGGAAGAAGA
AGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGC
GAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGG
AGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACT
CCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAGCACCAA
  • refseq_DTNB.F1 (forward primer)
  • refseq_DTNB.R1 (reverse primer)
  • Single exon skipping

Frame 0

GRAPAHPPSALRPRALAPGAGAARAGRRSGASR
ALRTFAAGVAPGPE*ALPLPQPRGLGRSVRRSEA
AGDLPDDPCSGGEVSKDD*GKWEQAEDHGREEA
AVHRNACSEF*CHTTINLQNSLQITICTKTMQP
SSC*YLEHD*SLPRQWP*YTGPYHRDQCVPPRNC
HLLHLLSVEQAPSFYSPN*CGTIYQPPPQLYDC
CI*Q*GPRQVDGIFS*SYVSNHVWWKNAGQIEI
CFLPDVRFQWLNDI*QV*PVSEGSSEAPNSCL*R
AIFWLHRALSPHLFSTAEKDNAKYVFRHNDG*P
SSPVPCLATSHAQACPC*ECLPSRGVLLLPM*E
YDGFPVPMPAVPQLSALPELLLAWPCRRPSQQPA
PDEGAFLLEISCKEAEPCN**IFGVCTHERTPA
SCFS*ATRETT*PCTYSSSSPSD*YE*HHG*PH
VLWSAHSHQEVTV*PGYTQSLGR*ACADSLLCGP
SAALCTCSGQS*PTG*GTPSYSSLCCPAGCRSR
KRDSSSH*LEL*L*CQQTTKTAYCRTGKQKQRD
PAGDSASPPGTRAGLPAHP*EGTAEPHAAGRAAA
AEAKEG*TGAEDVGPAGEQAGADGPAGRADEVA
EGGRAKAGSSGHRVTTYIAHPWRRPANAHASAL
HVCRLHPHPLSAGLAERSRGRRAGGLRTRYEEKP
PQ*PAGGS*LHHQHHVIPGEGAPFS
RGRCRGRR
REDAEWERQRLAEEPDTEEAQAQRTRSKLAPTW
RRQGLPPEAHSSPSFHRTPGPGLQAARRHSTRQG
EGSQSRWEAGRGCVAQLVGLPLHSPACTSTFIT
PLRAWSHLRIRNSPGG*KEKRKST

Frame 1

GARPPIRPPPSALAPSRRGRALRVPGGEAARAG
RCERSPRGWLRGLSRRCRCLSRGGWAGACGGVR
PQETFPTTPAPAGK*ARMIEESGNKRKTMAEKRQ
LFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNL
HLVDIWNMIEAFRDNGLNTLDHTTEISVSRLET
VISSIYYQLNKRLPSTHQISVEQSISLLLNFMIA
AYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRY
VFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFE
GPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADP
PPQCLVWLPLMHRLAHVENVFHPVECSYCRCES
MMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQ
HQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPH
PVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHM
SSGVPTPTKRLQYSQDIPSHLADEHALIASYVA
RLQHCARVLDSPSRLDEEHRLIARYAARLAAEAG
NVTRPPTDLSFNFDANKQQRQLIAELENKNREI
LQEIQRLRLEHEQASQPTPEKAQQNPTLLAELR
LLRQRKDELEQRMSALQESRRELMVQLEELMKLL
KEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS
TSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRN
LRNDLLVAADSITNTMSSLVKELHS
AEEGAEEEE
EKMQNGKDRG*QRSRTQRKLRHRGRGASWRRHG
EGKVFPQRHIPLHLSTAHLDQACRLPDVTPPAR
ERGARAGGKRGGAAWHS*WASPCTALHVLAPSSL
PSGHGLISASGIHLEVEKRKEKAP

Frame 2

ARARPSALRPPPSRPRAGGGRCACRAEKRREPG
AANVRRGGGSGA*VGAAAASAEGAGPERAEE*G
RRRPSRRPLLRRGSEQG*LRKVGTSGRPWQRRG
SCS*KCVLRILMSYDYQLTEQPANYDLYKNDATF
ILLISGT*LKPSETMALIHWTIPPRSVCPASKL
SSPPSTIS*TSAFLLLTKLVWNNLSASSSTL*L
LHMTVRAEAS*RYFQLKLC*QPCVVEKCWTN*DM
FSPRCQIPMA**YLASLTSF*RKF*SSQQLSLK
GHLLVTQSTQSAPVFHSRER*C*ICF*TQ*WLT
LLPSALSGYLSCTGLPMLRMSSIPWSAPTADVRV
*WVSGTDASSATTISSARIAFGVAMPAALTATS
TR*RSIPLGNLLQRS*AMQLVNLWGVYPRENPR
ILFFLSNQRNHLTLHI*FLLAL*LI*MTPWLATC
PLECPLPPRGYSIARIYPVTWPMSMR**PPMWP
VCSTVHVFWTVLADWMRNTVL*LAMLPGWLQKQ
ET*LVLPLT*ALTLMPTNNKDSLLQNWKTKTERS
CRRFSVSAWNTSRPPSPPLRRHSRTPRCWQSCG
C*GKGRMNWSRGCRPCRRAGGS*WSSWKS**SC
*RRKSKSRQLRPQGHHIHRPPMEAAGQCPCQCAP
RLPAPPPPTVRRTR*AESGETCRRPSHKVRGET
SAMTCWWQLTPSPTPCHPW*RSSIQ
QRKVQRKK
KRRCRMGKTEVSRGAGHRGSSGTEDEEQAGADMA
KARSSPRGTFLSIFPPHTWTRLAGCQTSLHPPG
RGEPEPVGSGEGLRGTASGPPPAQPCMY*HLHH
SPQGMVSSPHQEFTWRLKREKKKHQ

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