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Sequences

Sequence NM_032980

GTGAGTGTTGCCCAGAGTTAAAGGGAATATCAAGGATGGTGGCAGAATTAAAGGGCAAACTTACCTTCCATCCCAGGTCTAGTATTCAGTCCCCCTTCCT
CCCACTCTCCACCCTACTGCGTGCTCTTACTTATTCTGTTGGAACCCAGTGTAGCTTCCTGAGATTTAAAATATAGGAAGACTCAAAACTATGTTACTTC
TTGGAATATAGATAATTCAGTACTGATTTAAATAACAACTGAATAGCAAGGACCTTCTGGAACATAATCTTACATTCACAAAATCACCTGCTAAGAAGCT
GACTAATGCATTAAGCAAGTCCCTGAGCTGTGCTTCCAGCCGTGAACCTTTGCACCCCATGTTCCCAGATCAGCCTGAGAAGCCACTCAACTTGGCTCAC
ATCGTGCCTCCCAGACCTGTAACCAGCATGAACGACACCCTGTTCTCCCACTCTGTTCCCTCCTCAGGAAGTCCTTTTATTACCAGGAGCTCTCCTCCCA
AGGACAGTG
AAGTAGAGCAGAACAAACTGCTGGCTAGGGCTGCTCCAGCTTTTCTGAAGGGCAAAGGCATGCTTGAGAGTTCAAACCGGCTTGATGAAGA
ACACAGGCTAATTGCCAGGTATGCGGCAAGGCTGGCAGCAGAGTCCTCTTCGTCTCAGCCACCTCAGCAGAGAAGTGCTCCTGACATCTCTTTCACCATC
GATGCGAATAAGCAGCAAAGGCAGCTGATTGCTGAGCTAGAAAACAAGAACAGAGAAATCTTACAGGAGATCCAGAGACTTCGGCTAGAGCATGAACAAG
CTTCTCAGCCCACGCCAGAGAAGGCACAGCAAAACCCCACCCTGCTGGCAGAACTCCGGCTCCTCAGACAGCGCAAAGATGAGCTGGAACAGAGAATGTC
TGCTCTCCAGGAGAGCCGGAGAGAGCTAATGGTCCAGTTGGAGGGTCTCATGAAGCTACTAAAGACTCAGGGGGCAGGCTCTCCCCGCTCCTCCCCCAGC
CACACCATCAGCAGGCCAATTCCCATGCCCATCCGGTCAGCGTCAGCCTGCTCCACCCCGACGCACACGCCGCAGGACTCCCTCACAGGAGTAGGGGGAG
ATGTACAAGAGGCATTTGCACAAAGTTCAAGAAGAAACTTAAGGAATGACTTGCTAGTGGCTGCAGATTCCATCACTAACACTATGTCCTCTCTTGTGAA
AGAGCTGAATTCTGAGGTTGGGAGTGAAACAGAGAGTAATGTGGATTCTGAATTTGCACGGACTCAGTTTGAGGATCTTGTTCCCTCACCAACCTCTGAA
AAGGCTTTTCTAGCGCAAATCCATGCCCGAAAACCTGGGTACATTCACAGTGGAGCTACCACAAGTACCATGCGTGGCGACATGGTTACGGAGGATGCAG
ATCCCTATGTGCAGCCTGAAGATGAAAACTATGAAAATGACTCTGTCCGGCAGCTGGAGAATGAGCTCCAGATGGAGGAATACCTGAAACAGAAGCTGCA
AGATGAAGCTTATCAGGTCAGCTTGCAAGGTTGAATGCAATATCCTTTTATCACACTCCTCTCAAGCAAGCTATAGTCAGACAGATGATGAAAGTAACAT
GAAAACTGGTGATGATGGAGAGCCCTGTGGCCACACAGAGGAGGAAGACAGCAGCCTGGCAGCAGCCTCACCGAAGAGAGGAACCACCACACCCAGCAGC
TCCTGACAGACCCCCACCCCTAAAGATGTGTCCTGATGACTATAGTGCAGCTAACTTTTTGTTCTCAGATTTGTAGTGCATAGGTGTGTGTTTCAAGAAG
GAAAAAAAAAGACTTCTGTTCAAAGTTAACTTATCAGCTACATCCTCTGTAACGTGGTTCATCCCTGGTTAAAAAGCAAACAAACACAGGCTGAAAACCC
ATGCTGCTGTTATACACAATGGCAGTATTAACAAGCATTTTAAACCTTTGCACATGATATTGAACCTGTTCAGTTTACAATGACAATATTAATACTGTTT
ATAGCTAGAAGTTTGATTTCTGAATTCTTTGAGATTTTAGCAAAACAGTTTATTATACACTGTACATTTTTTTCACAGCAATTGGAAAAAAACAACCACT
TGCAATCATTCAATAACCCTGAAGAATTTGGTTCCTGAGTGTACAAACTCAGAGCCCGGAAGCCAAGAAGGGTCCTTGGCCTGCACGGTCTGTAGTTGAC
TCCAAGTCTCTGTGAGCAGTGACTTGAACCAAACACACCAGGAATAATCCATTCTTTGGGGCCTCTTTCCAACTCGAGGTTGTTTTCTTTCAAGATACTC
TAATCAGCCATAGAATTTAGTGTAAATATTTTTTTTTCCAAATAGATATCATATTCAAAAAAGGCAGCATTCAAATTATATAGAATCTAGTTTTTAAAAT
CAGCACAGATCTTCTTAAAAACTGTGAACTATGTTTTGAAATACTCGTTACTAAAGCTGTTTATAAACCACAGGTGCCATAAGATCCCCAAACGGACTAA
AGTTATCTCTGCTCTTCCATGGTCTTGTTCCTCTCGTTTTGGCTTTAGGAAGCATGTCTTTAACAGCACCGCTCGTTCACAAGTTCCCCCATCAAGTTGT
TTGGAGGCCTTCAGCTTTAAATGTACAGGCTTAAAGTGCGCTTGCAAACGTTTGCTCTCCTTTTTTTCTGAATGTTGATTGCCTTAGCTGGCCACCTGGT
GTTCTGCATGTAGCCTTCTGTGGTCATGTGAAAGGAGACAGGCTCTTCTAAGTTGAGTTGGGATTTTTGCACTCAGTGAAAAGCTGAAGTGCAAAAGAGC
TATCAAAGACAAGAGGATAAAAGACTGGGATAGTCTTTTCCAAGGACCCTCTTTAGAGGGCCCTAAAGACCTCCTTTGGGAATTCTGGGGAAAAAGAAAA
AGTAATCTTCTACTTGCTTCAAGATTTGATTTTTTTAAAAAAGCCTGCGACCTATTCAATACATTATGCTTAAATTAGCAGTTTCTCTGGAATTCCTGTC
TCTCCTTTAAAAGAAAGGAGAGAACATTTTAGAACAATAGTTCTCAAAGTGTGTTCCCCGGACAAGCAGCATCTGCAACACTTAGGAAGGTCTTCGAAAT
ACTAATTTGTAAGCCCCACCTCAGGCCTACTGAATCAGAAGCTCTGGGGGTTGGGTCCAGAAGTCTGTTTTAGTCAACCCTCTAGGTGATTCTGATGCTC
GCTAAAGGTTGAGAACTACTGCTTTAGAATGAAGTCGTATAATAAAGTCTCTGAAAAGGCCTTATTCAGAATAAGCAAGAAAGGTTCTGTGATTCACTTT
TGCTTCTGGGGCTGGCAAAAACCTTCTCTGAACCCACACACCAAGTTCGTAGTTGGTAGGTGCCCAGCCAAGTCCTGACATCTTCATGCCCCCTCTGCAG
AGGGCGGCTGTACGATGTTCACATGTCTGCGTTTGGTCAGACATCATCTCCTTGGCTGCCCTTTGAAACCAAATCACTTGCCTTGGGGATAAAGTGCTCA
ATTGGCATTAGTGAGAAGCCCATCCTATCCCTTGACATACTTAATCATATATCTCTCCAGAGAACTCACCTGACAAATGTCTCTGAGCACAGGCTGACAC
CAAAGTGGCACAACTGCACAGTTCTCAGATTTCTTTGCACAGATTGATTTTTATTGCGGGTTTTGTTGGGGTGTCTTAATGTTCATCTCTTTTCCACTGC
CCATCCTCTGTGAACCCATACCTCTCTAGATGGAGCAGGTGGCCACTGGTGCCTCATACTCAGTATTGAAAACCACTACATCCCAGCTACCTATAATGCT
GTCAGCTCAAAATCATAGCCAGGTAGTTCTTGAACTCAGAACTTAAATCCTGCACGTGGCACTCCACCACTGACTGGACCGAGCTGGCATATGTTGTTTC
TTTGTGTTTCTACATCAAAATGTTCGTCTAAGATTTGAACTGTTCTGCTGATAACCTTCCCCGTTGTCATAGCTATTTCATTGCCAACCAACTCCATCAC
ATGGTTGTTGATATCGTCATATAAAGCCATTGCAAGGACTCTGGAAACTGCCGCCAATGACCAATTTCTGACTAACCAGCCACCTTTTCTCTCTCTTAGC
TCCACGTCAGCACTGAGACCAGACTCGAGCACCCCTGTCCTGTAAGCGAGACAAAATGGCGTGTGTTATTTTGGGGTTTTGTGTTTTTTGGTGGGTTTCT
TTCCTTGGCTCTCCAGATTTACTTTTGGGGCCTGTTCTAAGTGCAAACCCAGCAAGTTTCACTTGTCCTGTCCATTAGATACAACTACATCTTGCGGGGG
TTGTTTCTTTCTTGTTCCACAATGAATTGCACATCCATCTCCATCAGAGCTGATAGCCTGTTAATAAGCACTGGTCTAACACAGCCAACCCTCCTCCACA
GCGCCATATTAATGGAGGAGGGGAGGAAGGTGAAATCTACTGCATGGGATTCAGGAAACAGTTGTGGTTGGTCAGGACGGAAGTTGGGGTAAGTTTGGTT
GGTCAGAGGGAGTTGTGCTGGAGATTGTGAAAAATGGGTTCTTGAATGATCTACTATAAGGCAGGGAAGGTTCATTTGTAAGTAGTAATGTGAACTGAAT
TGCATTAAGAGTGTGTGGCCTTTGTTGTGATATACTATGTATTTTCTTATATGCATGAGCCAAACTGTTGCATCATAATTTAGCACTGATGTCTGCTTTT
ATTTTGATCATCTTTGTCCACCCTTATTAGTTCTTGGCTGTTAACCGTAGATAGATCTTGTAAATCCAGCAACCTTTGGTTGCTGCATTCCCCTTGGTTC
GATTCCACGCAAGGAGCCACAAGTGAGAACTCCACTGTCCTTAGAAGAAAGGGCATTTTTACTTTTGAACCAAAAAGAGAAAAAAAAATCAGAAGTGTTG
CATCTTGAGGCGAATTAACTGTAAGACATTTTTAATTATGACTACTGCAATTTGACACCATTTGAAATAATCAATTCAGAGACACTAAAGATTTCACAAT
ATTCATTGGTATTGTAAAAAAAAAATACTATTGTATGGATTTTTGTATTGCTGTTAAGTATTGTTTTGTGTGTGTGTGTGTGTGTGTGTGTTGGAACCTC
CTGGGGACATGTTATATTTTGAAGTGATTAAACTATTTAATTGTGTGTCTATATTTTGGAGTGGAATAATTTCTTCATTAAAAAATGTTTTTAAAAACAC
TA
  • refseq_DTNA.F4 (forward primer)
  • refseq_DTNA.R1 (reverse primer)
  • Single exon skipping

Frame 0

VSVAQS*REYQGWWQN*RANLPSIPGLVFSPPS
SHSPPYCVLLLILLEPSVAS*DLKYRKTQNYVTS
WNIDNSVLI*ITTE*QGPSGT*SYIHKITC*EA
D*CIKQVPELCFQP*TFAPHVPRSA*EATQLGS
HRASQTCNQHERHPVLPLCSLLRKSFYYQELSSQ
GQ*
SRAEQTAG*GCSSFSEGQRHA*EFKPA**R
TQANCQVCGKAGSRVLFVSATSAEKCS*HLFHH
RCE*AAKAADC*ARKQEQRNLTGDPETSARA*TS
FSAHAREGTAKPHPAGRTPAPQTAQR*AGTENV
CSPGEPERANGPVGGSHEATKDSGGRLSPLLPQ
PHHQQANSHAHPVSVSLLHPDAHAAGLPHRSRGR
CTRGICTKFKKKLKE*LASGCRFHH*HYVLSCE
RAEF*GWE*NRE*CGF*ICTDSV*GSCSLTNL*
KGFSSANPCPKTWVHSQWSYHKYHAWRHGYGGCR
SLCAA*R*KL*K*LCPAAGE*APDGGIPETEAA
R*SLSGQLARLNAISFYHTPLKQAIVRQMMKVT
*KLVMMESPVATQRRKTAAWQQPHRREEPPHPAA
PDRPPPLKMCPDDYSAANFLFSDL*CIGVCFKK
EKKRLLFKVNLSATSSVTWFIPG*KANKHRLKT
HAAVIHNGSINKHFKPLHMILNLFSLQ*QY*YCL
*LEV*FLNSLRF*QNSLLYTVHFFHSNWKKTTT
CNHSITLKNLVPECTNSEPGSQEGSLACTVCS*
LQVSVSSDLNQTHQE*SILWGLFPTRGCFLSRYS
NQP*NLV*IFFFPNRYHIQKRQHSNYIESSF*N
QHRSS*KL*TMF*NTRY*SCL*TTGAIRSPNGL
KLSLLFHGLVPLVLALGSMSLTAPLVHKFPHQVV
WRPSALNVQA*SALANVCSPFFLNVDCLSWPPG
VLHVAFCGHVKGDRLF*VELGFLHSVKS*SAKE
LSKTRG*KTGIVFSKDPL*RALKTSFGNSGEKEK
VIFYLLQDLIFLKKPATYSIHYA*ISSFSGIPV
SPLKERREHFRTIVLKVCSPDKQHLQHLGRSSK
Y*FVSPTSGLLNQKLWGLGPEVCFSQPSR*F*CS
LKVENYCFRMKSYNKVSEKALFRISKKGSVIHF
CFWGWQKPSLNPHTKFVVGRCPAKS*HLHAPSA
EGGCTMFTCLRLVRHHLLGCPLKPNHLPWG*SAQ
LALVRSPSYPLTYLIIYLSRELT*QMSLSTG*H
QSGTTAQFSDFFAQIDFYCGFCWGVLMFISFPL
PILCEPIPL*MEQVATGASYSVLKTTTSQLPIML
SAQNHSQVVLELRT*ILHVALHH*LDRAGICCF
FVFLHQNVRLRFELFC**PSPLS*LFHCQPTPS
HGC*YRHIKPLQGLWKLPPMTNF*LTSHLFSLLA
PRQH*DQTRAPLSCKRDKMACVILGFCVFWWVS
FLGSPDLLLGPVLSANPASFTCPVH*IQLHLAG
VVSFLFHNELHIHLHQS**PVNKHWSNTANPPPQ
RHINGGGEEGEIYCMGFRKQLWLVRTEVGVSLV
GQRELCWRL*KMGS*MIYYKAGKVHL*VVM*TE
LH*ECVAFVVIYYVFSYMHEPNCCIII*H*CLLL
F*SSLSTLISSWLLTVDRSCKSSNLWLLHSPWF
DSTQGATSENSTVLRRKGIFTFEPKREKKIRSV
AS*GELTVRHF*L*LLQFDTI*NNQFRDTKDFTI
FIGIVKKKYYCMDFCIAVKYCFVCVCVCVCWNL
LGTCYILK*LNYLIVCLYFGVE*FLH*KMFLKT
L

Frame 1

*VLPRVKGNIKDGGRIKGQTYLPSQV*YSVPLP
PTLHPTACSYLFCWNPV*LPEI*NIGRLKTMLL
LGI*IIQY*FK*QLNSKDLLEHNLTFTKSPAKKL
TNALSKSLSCASSREPLHPMFPDQPEKPLNLAH
IVPPRPVTSMNDTLFSHSVPSSGSPFITRSSPP
KDS
EVEQNKLLARAAPAFLKGKGMLESSNRLDEE
HRLIARYAARLAAESSSSQPPQQRSAPDISFTI
DANKQQRQLIAELENKNREILQEIQRLRLEHEQ
ASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMS
ALQESRRELMVQLEGLMKLLKTQGAGSPRSSPS
HTISRPIPMPIRSASACSTPTHTPQDSLTGVGG
DVQEAFAQSSRRNLRNDLLVAADSITNTMSSLVK
ELNSEVGSETESNVDSEFARTQFEDLVPSPTSE
KAFLAQIHARKPGYIHSGATTSTMRGDMVTEDA
DPYVQPEDENYENDSVRQLENELQMEEYLKQKLQ
DEAYQVSLQG*MQYPFITLLSSKL*SDR**K*H
ENW**WRALWPHRGGRQQPGSSLTEERNHHTQQ
LLTDPHP*RCVLMTIVQLTFCSQICSA*VCVSRR
KKKDFCSKLTYQLHPL*RGSSLVKKQTNTG*KP
MLLLYTMAVLTSILNLCT*Y*TCSVYNDNINTV
YS*KFDF*IL*DFSKTVYYTLYIFFTAIGKKQPL
AIIQ*P*RIWFLSVQTQSPEAKKGPWPARSVVD
SKSL*AVT*TKHTRNNPFFGASFQLEVVFFQDT
LISHRI*CKYFFFQIDIIFKKGSIQII*NLVFKI
STDLLKNCELCFEILVTKAVYKPQVP*DPQTD*
SYLCSSMVLFLSFWL*EACL*QHRSFTSSPIKL
FGGLQL*MYRLKVRLQTFALLFF*MLIALAGHLV
FCM*PSVVM*KETGSSKLSWDFCTQ*KAEVQKS
YQRQEDKRLG*SFPRTLFRGP*RPPLGILGKKK
K*SSTCFKI*FF*KSLRPIQYIMLKLAVSLEFLS
LL*KKGENILEQ*FSKCVPRTSSICNT*EGLRN
TNL*APPQAY*IRSSGGWVQKSVLVNPLGDSDA
R*RLRTTALE*SRIIKSLKRPYSE*ARKVL*FTF
ASGAGKNLL*THTPSS*LVGAQPSPDIFMPPLQ
RAAVRCSHVCVWSDIISLAAL*NQITCLGDKVL
NWH**EAHPIP*HT*SYISPENSPDKCL*AQADT
KVAQLHSSQISLHRLIFIAGFVGVS*CSSLFHC
PSSVNPYLSRWSRWPLVPHTQY*KPLHPSYL*C
CQLKIIAR*FLNSELKSCTWHSTTDWTELAYVVS
LCFYIKMFV*DLNCSADNLPRCHSYFIANQLHH
MVVDIVI*SHCKDSGNCRQ*PISD*PATFSLS*
LHVSTETRLEHPCPVSETKWRVLFWGFVFFGGFL
SLALQIYFWGLF*VQTQQVSLVLSIRYNYILRG
LFLSCSTMNCTSISIRADSLLISTGLTQPTLLH
SAILMEEGRKVKSTAWDSGNSCGWSGRKLG*VWL
VRGSCAGDCEKWVLE*STIRQGRFICK**CELN
CIKSVWPLL*YTMYFLICMSQTVAS*FSTDVCF
YFDHLCPPLLVLGC*P*IDLVNPATFGCCIPLGS
IPRKEPQVRTPLSLEERAFLLLNQKEKKKSEVL
HLEAN*L*DIFNYDYCNLTPFEIINSETLKISQ
YSLVL*KKNTIVWIFVLLLSIVLCVCVCVCVGTS
WGHVIF*SD*TI*LCVYILEWNNFFIKKCF*KH

Frame 2

ECCPELKGISRMVAELKGKLTFHPRSSIQSPFL
PLSTLLRALTYSVGTQCSFLRFKI*EDSKLCYF
LEYR*FSTDLNNN*IARTFWNIILHSQNHLLRS
*LMH*ASP*AVLPAVNLCTPCSQISLRSHSTWLT
SCLPDL*PA*TTPCSPTLFPPQEVLLLPGALLP
RTV
K*SRTNCWLGLLQLF*RAKACLRVQTGLMK
NTG*LPGMRQGWQQSPLRLSHLSREVLLTSLSPS
MRISSKGS*LLS*KTRTEKSYRRSRDFG*SMNK
LLSPRQRRHSKTPPCWQNSGSSDSAKMSWNREC
LLSRRAGES*WSSWRVS*SY*RLRGQALPAPPPA
TPSAGQFPCPSGQRQPAPPRRTRRRTPSQE*GE
MYKRHLHKVQEET*GMTC*WLQIPSLTLCPLL*
KS*ILRLGVKQRVMWILNLHGLSLRILFPHQPLK
RLF*RKSMPENLGTFTVELPQVPCVATWLRRMQ
IPMCSLKMKTMKMTLSGSWRMSSRWRNT*NRSC
KMKLIRSACKVECNILLSHSSQASYSQTDDESNM
KTGDDGEPCGHTEEEDSSLAAASPKRGTTTPSS
S*QTPTPKDVS**L*CS*LFVLRFVVHRCVFQE
GKKKTSVQS*LISYILCNVVHPWLKSKQTQAENP
CCCYTQWQY*QAF*TFAHDIEPVQFTMTILILF
IARSLISEFFEILAKQFIIHCTFFSQQLEKNNH
LQSFNNPEEFGS*VYKLRARKPRRVLGLHGL*LT
PSLCEQ*LEPNTPGIIHSLGPLSNSRLFSFKIL
*SAIEFSVNIFFSK*ISYSKKAAFKLYRI*FLK
SAQIFLKTVNYVLKYSLLKLFINHRCHKIPKRTK
VISALPWSCSSRFGFRKHVFNSTARSQVPPSSC
LEAFSFKCTGLKCACKRLLSFFSEC*LP*LATW
CSACSLLWSCERRQALLS*VGIFALSEKLKCKRA
IKDKRIKDWDSLFQGPSLEGPKDLLWEFWGKRK
SNLLLASRFDFFKKACDLFNTLCLN*QFLWNSC
LSFKRKERTF*NNSSQSVFPGQAASATLRKVFEI
LICKPHLRPTESEALGVGSRSLF*STL*VILML
AKG*ELLL*NEVV**SL*KGLIQNKQERFCDSL
LLLGLAKTFSEPTHQVRSW*VPSQVLTSSCPLCR
GRLYDVHMSAFGQTSSPWLPFETKSLALGIKCS
IGISEKPILSLDILNHISLQRTHLTNVSEHRLT
PKWHNCTVLRFLCTD*FLLRVLLGCLNVHLFSTA
HPL*THTSLDGAGGHWCLILSIENHYIPATYNA
VSSKS*PGSS*TQNLNPARGTPPLTGPSWHMLF
LCVSTSKCSSKI*TVLLITFPVVIAISLPTNSIT
WLLISSYKAIARTLETAANDQFLTNQPPFLSLS
STSALRPDSSTPVL*ARQNGVCYFGVLCFLVGF
FPWLSRFTFGACSKCKPSKFHLSCPLDTTTSCGG
CFFLVPQ*IAHPSPSELIAC**ALV*HSQPSST
APY*WRRGGR*NLLHGIQETVVVGQDGSWGKFG
WSEGVVLEIVKNGFLNDLL*GREGSFVSSNVN*I
ALRVCGLCCDILCIFLYA*AKLLHHNLALMSAF
ILIIFVHPY*FLAVNRR*IL*IQQPLVAAFPLV
RFHARSHK*ELHCP*KKGHFYF*TKKRKKNQKCC
ILRRINCKTFLIMTTAI*HHLK*SIQRH*RFHN
IHWYCKKKILLYGFLYCC*VLFCVCVCVCVLEP
PGDMLYFEVIKLFNCVSIFWSGIISSLKNVFKNT

Sequence NM_001390

GATTGCTGTGTGTTGAGCACAAGGGGAAGAATGAACACAGCTTTTTATTGAAGTTAAAGGTTACTTTGGAGTTTGTTTGGAAATGTGTAAGGTCAAATAC
TATAGTTTTCAGCATATGTAGTACTTCAGAGGAAGAATTAAGGGGCATGTTGGTGCATTTAACTACAAAACCAGGTGGCAGGTTGCTGCTCTCTCCTTCA
GAACCCCGCTCTGAGGAAAGCTAAGGAAGAGAACAGGACGTCTGAGTGTGTGACTGAGAATGATTGAAGATAGTGGGAAAAGAGGAAATACCATGGCAGA
AAGAAGACAGCTGTTTGCAGAGATGAGGGCTCAAGATCTGGATCGCATCCGACTCTCCACCTACAGAACAGCATGCAAGCTTAGGTTTGTTCAGAAGAAA
TGCAATTTGCACCTGGTGGACATATGGAATGTCATAGAAGCATTGCGGGAAAATGCTCTGAACAACCTGGACCCAAACACTGAACTCAACGTGTCCCGCT
TAGAGGCTGTGCTCTCCACTATTTTTTACCAGCTCAACAAACGGATGCCAACCACTCACCAAATCCATGTGGAGCAGTCCATCAGCCTCCTCCTTAACTT
CCTGCTTGCAGCGTTTGATCCGGAAGGCCATGGTAAAATTTCAGTATTTGCTGTCAAAATGGCTTTAGCCACATTGTGTGGAGGGAAGATCATGGACAAA
TTAAGATATATTTTCTCAATGATTTCTGACTCCAGTGGGGTGATGGTTTATGGACGATATGACCAATTCCTTCGGGAAGTTCTCAAACTACCCACGGCAG
TTTTTGAAGGTCCTTCATTTGGTTACACAGAACAGTCAGCCAGATCCTGTTTCTCCCAACAGAAAAAAGTCACGTTAAATGGTTTCTTGGACACGCTTAT
GTCAGATCCTCCCCCGCAGTGTCTGGTCTGGTTGCCTCTTCTGCATCGACTAGCAAATGTGGAAAATGTCTTCCATCCGGTTGAGTGTTCCTACTGCCAC
AGTGAGAGTATGATGGGATTTCGCTACCGATGCCAACAGTGTCACAATTACCAGCTCTGTCAGGACTGCTTCTGGAGGGGACATGCCGGTGGTTCTCATA
GCAACCAGCACCAAATGAAAGAGTACACGTCATGGAAATCACCTGCTAAGAAGCTGACTAATGCATTAAGCAAGTCCCTGAGCTGTGCTTCCAGCCGTGA
ACCTTTGCACCCCATGTTCCCAGATCAGCCTGAGAAGCCACTCAACTTGGCTCACATCGTTGATACTTGGCCTCCCAGACCTGTAACCAGCATGAACGAC
ACCCTGTTCTCCCACTCTGTTCCCTCCTCAGGAAGTCCTTTTATTACCAGGAGCTCTCCTCCCAAGGACAGTGAAGTAGAGCAGAACAAACTGCTGGCTA
GGGCTGCTCCAGCTTTTCTGAAGGGCAAAGGGATACAGTACAGCCTGAATGTGGCAGACAGGCTAGCTGATGAACATGTTCTCATCGGGTTGTATGTCAA
CATGCTCCGGAACAACCCCTCATG
CATGCTTGAGAGTTCAAACCGGCTTGATGAAGAACACAGGCTAATTGCCAGGTATGCGGCAAGGCTGGCAGCAGAG
TCCTCTTCGTCTCAGCCACCTCAGCAGAGAAGTGCTCCTGACATCTCTTTCACCATCGATGCGAATAAGCAGCAAAGGCAGCTGATTGCTGAGCTAGAAA
ACAAGAACAGAGAAATCTTACAGGAGATCCAGAGACTTCGGCTAGAGCATGAACAAGCTTCTCAGCCCACGCCAGAGAAGGCACAGCAAAACCCCACCCT
GCTGGCAGAACTCCGGCTCCTCAGACAGCGCAAAGATGAGCTGGAACAGAGAATGTCTGCTCTCCAGGAGAGCCGGAGAGAGCTAATGGTCCAGTTGGAG
GGTCTCATGAAGCTACTAAAGACTCAGGGGGCAGGCTCTCCCCGCTCCTCCCCCAGCCACACCATCAGCAGGCCAATTCCCATGCCCATCCGGTCAGCGT
CAGCCTGCTCCACCCCGACGCACACGCCGCAGGACTCCCTCACAGGAGTAGGGGGAGATGTACAAGAGGCATTTGCACAAAGTTCAAGAAGAAACTTAAG
GAATGACTTGCTAGTGGCTGCAGATTCCATCACTAACACTATGTCCTCTCTTGTGAAAGAGCTGAATTCTGAGGTTGGGAGTGAAACAGAGAGTAATGTG
GATTCTGAATTTGCACGGACTCAGTTTGAGGATCTTGTTCCCTCACCAACCTCTGAAAAGGCTTTTCTAGCGCAAATCCATGCCCGAAAACCTGGGTACA
TTCACAGTGGAGCTACCACAAGTACCATGCGTGGCGACATGGTTACGGAGGATGCAGATCCCTATGTGCAGCCTGAAGATGAAAACTATGAAAATGACTC
TGTCCGGCAGCTGGAGAATGAGCTCCAGATGGAGGAATACCTGAAACAGAAGCTGCAAGATGAAGCTTATCAGGTCAGCTTGCAAGGTTGAATGCAATAT
CCTTTTATCACACTCCTCTCAAGCAAGCTATAGTCAGACAGATGATGAAAGTAACATGAAAACTGGTGATGATGGAGAGCCCTGTGGCCACACAGAGGAG
GAAGACAGCAGCCTGGCAGCAGCCTCACCGAAGAGAGGAACCACCACACCCAGCAGCTCCTGACAGACCCCCACCCCTAAAGATGTGTCCTGATGACTAT
AGTGCAGCTAACTTTTTGTTCTCAGATTTGTAGTGCATAGGTGTGTGTTTCAAGAAGGAAAAAAAAAGACTTCTGTTCAAAGTTAACTTATCAGCTACAT
CCTCTGTAACGTGGTTCATCCCTGGTTAAAAAGCAAACAAACACAGGCTGAAAACCCATGCTGCTGTTATACACAATGGCAGTATTAACAAGCATTTTAA
ACCTTTGCACATGATATTGAACCTGTTCAGTTTACAATGACAATATTAATACTGTTTATAGCTAGAAGTTTGATTTCTGAATTCTTTGAGATTTTAGCAA
AACAGTTTATTATACACTGTACATTTTTTTCACAGCAATTGGAAAAAAACAACCACTTGCAATCATTCAATAACCCTGAAGAATTTGGTTCCTGAGTGTA
CAAACTCAGAGCCCGGAAGCCAAGAAGGGTCCTTGGCCTGCACGGTCTGTAGTTGACTCCAAGTCTCTGTGAGCAGTGACTTGAACCAAACACACCAGGA
ATAATCCATTCTTTGGGGCCTCTTTCCAACTCGAGGTTGTTTTCTTTCAAGATACTCTAATCAGCCATAGAATTTAGTGTAAATATTTTTTTTTCCAAAT
AGATATCATATTCAAAAAAGGCAGCATTCAAATTATATAGAATCTAGTTTTTAAAATCAGCACAGATCTTCTTAAAAACTGTGAACTATGTTTTGAAATA
CTCGTTACTAAAGCTGTTTATAAACCACAGGTGCCATAAGATCCCCAAACGGACTAAAGTTATCTCTGCTCTTCCATGGTCTTGTTCCTCTCGTTTTGGC
TTTAGGAAGCATGTCTTTAACAGCACCGCTCGTTCACAAGTTCCCCCATCAAGTTGTTTGGAGGCCTTCAGCTTTAAATGTACAGGCTTAAAGTGCGCTT
GCAAACGTTTGCTCTCCTTTTTTTCTGAATGTTGATTGCCTTAGCTGGCCACCTGGTGTTCTGCATGTAGCCTTCTGTGGTCATGTGAAAGGAGACAGGC
TCTTCTAAGTTGAGTTGGGATTTTTGCACTCAGTGAAAAGCTGAAGTGCAAAAGAGCTATCAAAGACAAGAGGATAAAAGACTGGGATAGTCTTTTCCAA
GGACCCTCTTTAGAGGGCCCTAAAGACCTCCTTTGGGAATTCTGGGGAAAAAGAAAAAGTAATCTTCTACTTGCTTCAAGATTTGATTTTTTTAAAAAAG
CCTGCGACCTATTCAATACATTATGCTTAAATTAGCAGTTTCTCTGGAATTCCTGTCTCTCCTTTAAAAGAAAGGAGAGAACATTTTAGAACAATAGTTC
TCAAAGTGTGTTCCCCGGACAAGCAGCATCTGCAACACTTAGGAAGGTCTTCGAAATACTAATTTGTAAGCCCCACCTCAGGCCTACTGAATCAGAAGCT
CTGGGGGTTGGGTCCAGAAGTCTGTTTTAGTCAACCCTCTAGGTGATTCTGATGCTCGCTAAAGGTTGAGAACTACTGCTTTAGAATGAAGTCGTATAAT
AAAGTCTCTGAAAAGGCCTTATTCAGAATAAGCAAGAAAGGTTCTGTGATTCACTTTTGCTTCTGGGGCTGGCAAAAACCTTCTCTGAACCCACACACCA
AGTTCGTAGTTGGTAGGTGCCCAGCCAAGTCCTGACATCTTCATGCCCCCTCTGCAGAGGGCGGCTGTACGATGTTCACATGTCTGCGTTTGGTCAGACA
TCATCTCCTTGGCTGCCCTTTGAAACCAAATCACTTGCCTTGGGGATAAAGTGCTCAATTGGCATTAGTGAGAAGCCCATCCTATCCCTTGACATACTTA
ATCATATATCTCTCCAGAGAACTCACCTGACAAATGTCTCTGAGCACAGGCTGACACCAAAGTGGCACAACTGCACAGTTCTCAGATTTCTTTGCACAGA
TTGATTTTTATTGCGGGTTTTGTTGGGGTGTCTTAATGTTCATCTCTTTTCCACTGCCCATCCTCTGTGAACCCATACCTCTCTAGATGGAGCAGGTGGC
CACTGGTGCCTCATACTCAGTATTGAAAACCACTACATCCCAGCTACCTATAATGCTGTCAGCTCAAAATCATAGCCAGGTAGTTCTTGAACTCAGAACT
TAAATCCTGCACGTGGCACTCCACCACTGACTGGACCGAGCTGGCATATGTTGTTTCTTTGTGTTTCTACATCAAAATGTTCGTCTAAGATTTGAACTGT
TCTGCTGATAACCTTCCCCGTTGTCATAGCTATTTCATTGCCAACCAACTCCATCACATGGTTGTTGATATCGTCATATAAAGCCATTGCAAGGACTCTG
GAAACTGCCGCCAATGACCAATTTCTGACTAACCAGCCACCTTTTCTCTCTCTTAGCTCCACGTCAGCACTGAGACCAGACTCGAGCACCCCTGTCCTGT
AAGCGAGACAAAATGGCGTGTGTTATTTTGGGGTTTTGTGTTTTTTGGTGGGTTTCTTTCCTTGGCTCTCCAGATTTACTTTTGGGGCCTGTTCTAAGTG
CAAACCCAGCAAGTTTCACTTGTCCTGTCCATTAGATACAACTACATCTTGCGGGGGTTGTTTCTTTCTTGTTCCACAATGAATTGCACATCCATCTCCA
TCAGAGCTGATAGCCTGTTAATAAGCACTGGTCTAACACAGCCAACCCTCCTCCACAGCGCCATATTAATGGAGGAGGGGAGGAAGGTGAAATCTACTGC
ATGGGATTCAGGAAACAGTTGTGGTTGGTCAGGACGGAAGTTGGGGTAAGTTTGGTTGGTCAGAGGGAGTTGTGCTGGAGATTGTGAAAAATGGGTTCTT
GAATGATCTACTATAAGGCAGGGAAGGTTCATTTGTAAGTAGTAATGTGAACTGAATTGCATTAAGAGTGTGTGGCCTTTGTTGTGATATACTATGTATT
TTCTTATATGCATGAGCCAAACTGTTGCATCATAATTTAGCACTGATGTCTGCTTTTATTTTGATCATCTTTGTCCACCCTTATTAGTTCTTGGCTGTTA
ACCGTAGATAGATCTTGTAAATCCAGCAACCTTTGGTTGCTGCATTCCCCTTGGTTCGATTCCACGCAAGGAGCCACAAGTGAGAACTCCACTGTCCTTA
GAAGAAAGGGCATTTTTACTTTTGAACCAAAAAGAGAAAAAAAAATCAGAAGTGTTGCATCTTGAGGCGAATTAACTGTAAGACATTTTTAATTATGACT
ACTGCAATTTGACACCATTTGAAATAATCAATTCAGAGACACTAAAGATTTCACAATATTCATTGGTATTGTAAAAAAAAAATACTATTGTATGGATTTT
TGTATTGCTGTTAAGTATTGTTTTGTGTGTGTGTGTGTGTGTGTGTGTTGGAACCTCCTGGGGACATGTTATATTTTGAAGTGATTAAACTATTTAATTG
TGTGTCTATATTTTGGAGTGGAATAATTTCTTCATTAAAAAATGTTTTTAAAAACACTA
  • refseq_DTNA.F4 (forward primer)
  • refseq_DTNA.R1 (reverse primer)
  • Single exon skipping

Frame 0

DCCVLSTRGRMNTAFY*S*RLLWSLFGNV*GQI
L*FSAYVVLQRKN*GACWCI*LQNQVAGCCSLLQ
NPALRKAKEENRTSECVTEND*R*WEKRKYHGR
KKTAVCRDEGSRSGSHPTLHLQNSMQA*VCSEE
MQFAPGGHMECHRSIAGKCSEQPGPKH*TQRVPL
RGCALHYFLPAQQTDANHSPNPCGAVHQPPP*L
PACSV*SGRPW*NFSICCQNGFSHIVWREDHGQ
IKIYFLNDF*LQWGDGLWTI*PIPSGSSQTTHGS
F*RSFIWLHRTVSQILFLPTEKSHVKWFLGHAY
VRSSPAVSGLVASSASTSKCGKCLPSG*VFLLP
Q*EYDGISLPMPTVSQLPALSGLLLEGTCRWFS*
QPAPNERVHVMEITC*EAD*CIKQVPELCFQP*
TFAPHVPRSA*EATQLGSHR*YLASQTCNQHER
HPVLPLCSLLRKSFYYQELSSQGQ*SRAEQTAG*
GCSSFSEGQRDTVQPECGRQAS**TCSHRVVCQ
HAPEQPLM
HA*EFKPA**RTQANCQVCGKAGSR
VLFVSATSAEKCS*HLFHHRCE*AAKAADC*ARK
QEQRNLTGDPETSARA*TSFSAHAREGTAKPHP
AGRTPAPQTAQR*AGTENVCSPGEPERANGPVG
GSHEATKDSGGRLSPLLPQPHHQQANSHAHPVSV
SLLHPDAHAAGLPHRSRGRCTRGICTKFKKKLK
E*LASGCRFHH*HYVLSCERAEF*GWE*NRE*C
GF*ICTDSV*GSCSLTNL*KGFSSANPCPKTWVH
SQWSYHKYHAWRHGYGGCRSLCAA*R*KL*K*L
CPAAGE*APDGGIPETEAAR*SLSGQLARLNAI
SFYHTPLKQAIVRQMMKVT*KLVMMESPVATQRR
KTAAWQQPHRREEPPHPAAPDRPPPLKMCPDDY
SAANFLFSDL*CIGVCFKKEKKRLLFKVNLSAT
SSVTWFIPG*KANKHRLKTHAAVIHNGSINKHFK
PLHMILNLFSLQ*QY*YCL*LEV*FLNSLRF*Q
NSLLYTVHFFHSNWKKTTTCNHSITLKNLVPEC
TNSEPGSQEGSLACTVCS*LQVSVSSDLNQTHQE
*SILWGLFPTRGCFLSRYSNQP*NLV*IFFFPN
RYHIQKRQHSNYIESSF*NQHRSS*KL*TMF*N
TRY*SCL*TTGAIRSPNGLKLSLLFHGLVPLVLA
LGSMSLTAPLVHKFPHQVVWRPSALNVQA*SAL
ANVCSPFFLNVDCLSWPPGVLHVAFCGHVKGDR
LF*VELGFLHSVKS*SAKELSKTRG*KTGIVFSK
DPL*RALKTSFGNSGEKEKVIFYLLQDLIFLKK
PATYSIHYA*ISSFSGIPVSPLKERREHFRTIV
LKVCSPDKQHLQHLGRSSKY*FVSPTSGLLNQKL
WGLGPEVCFSQPSR*F*CSLKVENYCFRMKSYN
KVSEKALFRISKKGSVIHFCFWGWQKPSLNPHT
KFVVGRCPAKS*HLHAPSAEGGCTMFTCLRLVRH
HLLGCPLKPNHLPWG*SAQLALVRSPSYPLTYL
IIYLSRELT*QMSLSTG*HQSGTTAQFSDFFAQ
IDFYCGFCWGVLMFISFPLPILCEPIPL*MEQVA
TGASYSVLKTTTSQLPIMLSAQNHSQVVLELRT
*ILHVALHH*LDRAGICCFFVFLHQNVRLRFEL
FC**PSPLS*LFHCQPTPSHGC*YRHIKPLQGLW
KLPPMTNF*LTSHLFSLLAPRQH*DQTRAPLSC
KRDKMACVILGFCVFWWVSFLGSPDLLLGPVLS
ANPASFTCPVH*IQLHLAGVVSFLFHNELHIHLH
QS**PVNKHWSNTANPPPQRHINGGGEEGEIYC
MGFRKQLWLVRTEVGVSLVGQRELCWRL*KMGS
*MIYYKAGKVHL*VVM*TELH*ECVAFVVIYYVF
SYMHEPNCCIII*H*CLLLF*SSLSTLISSWLL
TVDRSCKSSNLWLLHSPWFDSTQGATSENSTVL
RRKGIFTFEPKREKKIRSVAS*GELTVRHF*L*L
LQFDTI*NNQFRDTKDFTIFIGIVKKKYYCMDF
CIAVKYCFVCVCVCVCWNLLGTCYILK*LNYLI
VCLYFGVE*FLH*KMFLKTL

Frame 1

IAVC*AQGEE*TQLFIEVKGYFGVCLEMCKVKY
YSFQHM*YFRGRIKGHVGAFNYKTRWQVAALSF
RTPL*GKLRKRTGRLSV*LRMIEDSGKRGNTMAE
RRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKK
CNLHLVDIWNVIEALRENALNNLDPNTELNVSR
LEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNF
LLAAFDPEGHGKISVFAVKMALATLCGGKIMDK
LRYIFSMISDSSGVMVYGRYDQFLREVLKLPTA
VFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLM
SDPPPQCLVWLPLLHRLANVENVFHPVECSYCH
SESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSH
SNQHQMKEYTSWKSPAKKLTNALSKSLSCASSRE
PLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMND
TLFSHSVPSSGSPFITRSSPPKDSEVEQNKLLA
RAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVN
MLRNNPSC
MLESSNRLDEEHRLIARYAARLAAE
SSSSQPPQQRSAPDISFTIDANKQQRQLIAELE
NKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLE
GLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSA
SACSTPTHTPQDSLTGVGGDVQEAFAQSSRRNLR
NDLLVAADSITNTMSSLVKELNSEVGSETESNV
DSEFARTQFEDLVPSPTSEKAFLAQIHARKPGY
IHSGATTSTMRGDMVTEDADPYVQPEDENYENDS
VRQLENELQMEEYLKQKLQDEAYQVSLQG*MQY
PFITLLSSKL*SDR**K*HENW**WRALWPHRG
GRQQPGSSLTEERNHHTQQLLTDPHP*RCVLMTI
VQLTFCSQICSA*VCVSRRKKKDFCSKLTYQLH
PL*RGSSLVKKQTNTG*KPMLLLYTMAVLTSIL
NLCT*Y*TCSVYNDNINTVYS*KFDF*IL*DFSK
TVYYTLYIFFTAIGKKQPLAIIQ*P*RIWFLSV
QTQSPEAKKGPWPARSVVDSKSL*AVT*TKHTR
NNPFFGASFQLEVVFFQDTLISHRI*CKYFFFQI
DIIFKKGSIQII*NLVFKISTDLLKNCELCFEI
LVTKAVYKPQVP*DPQTD*SYLCSSMVLFLSFW
L*EACL*QHRSFTSSPIKLFGGLQL*MYRLKVRL
QTFALLFF*MLIALAGHLVFCM*PSVVM*KETG
SSKLSWDFCTQ*KAEVQKSYQRQEDKRLG*SFP
RTLFRGP*RPPLGILGKKKK*SSTCFKI*FF*KS
LRPIQYIMLKLAVSLEFLSLL*KKGENILEQ*F
SKCVPRTSSICNT*EGLRNTNL*APPQAY*IRS
SGGWVQKSVLVNPLGDSDAR*RLRTTALE*SRII
KSLKRPYSE*ARKVL*FTFASGAGKNLL*THTP
SS*LVGAQPSPDIFMPPLQRAAVRCSHVCVWSD
IISLAAL*NQITCLGDKVLNWH**EAHPIP*HT*
SYISPENSPDKCL*AQADTKVAQLHSSQISLHR
LIFIAGFVGVS*CSSLFHCPSSVNPYLSRWSRW
PLVPHTQY*KPLHPSYL*CCQLKIIAR*FLNSEL
KSCTWHSTTDWTELAYVVSLCFYIKMFV*DLNC
SADNLPRCHSYFIANQLHHMVVDIVI*SHCKDS
GNCRQ*PISD*PATFSLS*LHVSTETRLEHPCPV
SETKWRVLFWGFVFFGGFLSLALQIYFWGLF*V
QTQQVSLVLSIRYNYILRGLFLSCSTMNCTSIS
IRADSLLISTGLTQPTLLHSAILMEEGRKVKSTA
WDSGNSCGWSGRKLG*VWLVRGSCAGDCEKWVL
E*STIRQGRFICK**CELNCIKSVWPLL*YTMY
FLICMSQTVAS*FSTDVCFYFDHLCPPLLVLGC*
P*IDLVNPATFGCCIPLGSIPRKEPQVRTPLSL
EERAFLLLNQKEKKKSEVLHLEAN*L*DIFNYD
YCNLTPFEIINSETLKISQYSLVL*KKNTIVWIF
VLLLSIVLCVCVCVCVGTSWGHVIF*SD*TI*L
CVYILEWNNFFIKKCF*KH

Frame 2

LLCVEHKGKNEHSFLLKLKVTLEFVWKCVRSNT
IVFSICSTSEEELRGMLVHLTTKPGGRLLLSPS
EPRSEES*GREQDV*VCD*E*LKIVGKEEIPWQ
KEDSCLQR*GLKIWIASDSPPTEQHASLGLFRRN
AICTWWTYGMS*KHCGKML*TTWTQTLNSTCPA
*RLCSPLFFTSSTNGCQPLTKSMWSSPSASSLT
SCLQRLIRKAMVKFQYLLSKWL*PHCVEGRSWTN
*DIFSQ*FLTPVG*WFMDDMTNSFGKFSNYPRQ
FLKVLHLVTQNSQPDPVSPNRKKSR*MVSWTRL
CQILPRSVWSGCLFCID*QMWKMSSIRLSVPTAT
VRV*WDFATDANSVTITSSVRTASGGDMPVVLI
ATSTK*KSTRHGNHLLRS*LMH*ASP*AVLPAV
NLCTPCSQISLRSHSTWLTSLILGLPDL*PA*TT
PCSPTLFPPQEVLLLPGALLPRTVK*SRTNCWL
GLLQLF*RAKGYSTA*MWQTG*LMNMFSSGCMS
TCSGTTPH
ACLRVQTGLMKNTG*LPGMRQGWQQS
PLRLSHLSREVLLTSLSPSMRISSKGS*LLS*K
TRTEKSYRRSRDFG*SMNKLLSPRQRRHSKTPP
CWQNSGSSDSAKMSWNRECLLSRRAGES*WSSWR
VS*SY*RLRGQALPAPPPATPSAGQFPCPSGQR
QPAPPRRTRRRTPSQE*GEMYKRHLHKVQEET*
GMTC*WLQIPSLTLCPLL*KS*ILRLGVKQRVMW
ILNLHGLSLRILFPHQPLKRLF*RKSMPENLGT
FTVELPQVPCVATWLRRMQIPMCSLKMKTMKMT
LSGSWRMSSRWRNT*NRSCKMKLIRSACKVECNI
LLSHSSQASYSQTDDESNMKTGDDGEPCGHTEE
EDSSLAAASPKRGTTTPSSS*QTPTPKDVS**L
*CS*LFVLRFVVHRCVFQEGKKKTSVQS*LISYI
LCNVVHPWLKSKQTQAENPCCCYTQWQY*QAF*
TFAHDIEPVQFTMTILILFIARSLISEFFEILA
KQFIIHCTFFSQQLEKNNHLQSFNNPEEFGS*VY
KLRARKPRRVLGLHGL*LTPSLCEQ*LEPNTPG
IIHSLGPLSNSRLFSFKIL*SAIEFSVNIFFSK
*ISYSKKAAFKLYRI*FLKSAQIFLKTVNYVLKY
SLLKLFINHRCHKIPKRTKVISALPWSCSSRFG
FRKHVFNSTARSQVPPSSCLEAFSFKCTGLKCA
CKRLLSFFSEC*LP*LATWCSACSLLWSCERRQA
LLS*VGIFALSEKLKCKRAIKDKRIKDWDSLFQ
GPSLEGPKDLLWEFWGKRKSNLLLASRFDFFKK
ACDLFNTLCLN*QFLWNSCLSFKRKERTF*NNSS
QSVFPGQAASATLRKVFEILICKPHLRPTESEA
LGVGSRSLF*STL*VILMLAKG*ELLL*NEVV*
*SL*KGLIQNKQERFCDSLLLLGLAKTFSEPTHQ
VRSW*VPSQVLTSSCPLCRGRLYDVHMSAFGQT
SSPWLPFETKSLALGIKCSIGISEKPILSLDIL
NHISLQRTHLTNVSEHRLTPKWHNCTVLRFLCTD
*FLLRVLLGCLNVHLFSTAHPL*THTSLDGAGG
HWCLILSIENHYIPATYNAVSSKS*PGSS*TQN
LNPARGTPPLTGPSWHMLFLCVSTSKCSSKI*TV
LLITFPVVIAISLPTNSITWLLISSYKAIARTL
ETAANDQFLTNQPPFLSLSSTSALRPDSSTPVL
*ARQNGVCYFGVLCFLVGFFPWLSRFTFGACSKC
KPSKFHLSCPLDTTTSCGGCFFLVPQ*IAHPSP
SELIAC**ALV*HSQPSSTAPY*WRRGGR*NLL
HGIQETVVVGQDGSWGKFGWSEGVVLEIVKNGFL
NDLL*GREGSFVSSNVN*IALRVCGLCCDILCI
FLYA*AKLLHHNLALMSAFILIIFVHPY*FLAV
NRR*IL*IQQPLVAAFPLVRFHARSHK*ELHCP*
KKGHFYF*TKKRKKNQKCCILRRINCKTFLIMT
TAI*HHLK*SIQRH*RFHNIHWYCKKKILLYGF
LYCC*VLFCVCVCVCVLEPPGDMLYFEVIKLFNC
VSIFWSGIISSLKNVFKNT

Sequence NM_001391

GATTGCTGTGTGTTGAGCACAAGGGGAAGAATGAACACAGCTTTTTATTGAAGTTAAAGGTTACTTTGGAGTTTGTTTGGAAATGTGTAAGGTCAAATAC
TATAGTTTTCAGCATATGTAGTACTTCAGAGGAAGAATTAAGGGGCATGTTGGTGCATTTAACTACAAAACCAGGTGGCAGGTTGCTGCTCTCTCCTTCA
GAACCCCGCTCTGAGGAAAGCTAAGGAAGAGAACAGGACGTCTGAGTGTGTGACTGAGAATGATTGAAGATAGTGGGAAAAGAGGAAATACCATGGCAGA
AAGAAGACAGCTGTTTGCAGAGATGAGGGCTCAAGATCTGGATCGCATCCGACTCTCCACCTACAGAACAGCATGCAAGCTTAGGTTTGTTCAGAAGAAA
TGCAATTTGCACCTGGTGGACATATGGAATGTCATAGAAGCATTGCGGGAAAATGCTCTGAACAACCTGGACCCAAACACTGAACTCAACGTGTCCCGCT
TAGAGGCTGTGCTCTCCACTATTTTTTACCAGCTCAACAAACGGATGCCAACCACTCACCAAATCCATGTGGAGCAGTCCATCAGCCTCCTCCTTAACTT
CCTGCTTGCAGCGTTTGATCCGGAAGGCCATGGTAAAATTTCAGTATTTGCTGTCAAAATGGCTTTAGCCACATTGTGTGGAGGGAAGATCATGGACAAA
TTAAGATATATTTTCTCAATGATTTCTGACTCCAGTGGGGTGATGGTTTATGGACGATATGACCAATTCCTTCGGGAAGTTCTCAAACTACCCACGGCAG
TTTTTGAAGGTCCTTCATTTGGTTACACAGAACAGTCAGCCAGATCCTGTTTCTCCCAACAGAAAAAAGTCACGTTAAATGGTTTCTTGGACACGCTTAT
GTCAGATCCTCCCCCGCAGTGTCTGGTCTGGTTGCCTCTTCTGCATCGACTAGCAAATGTGGAAAATGTCTTCCATCCGGTTGAGTGTTCCTACTGCCAC
AGTGAGAGTATGATGGGATTTCGCTACCGATGCCAACAGTGTCACAATTACCAGCTCTGTCAGGACTGCTTCTGGAGGGGACATGCCGGTGGTTCTCATA
GCAACCAGCACCAAATGAAAGAGTACACGTCATGGAAATCACCTGCTAAGAAGCTGACTAATGCATTAAGCAAGTCCCTGAGCTGTGCTTCCAGCCGTGA
ACCTTTGCACCCCATGTTCCCAGATCAGCCTGAGAAGCCACTCAACTTGGCTCACATCGTTGATACTTGGCCTCCCAGACCTGTAACCAGCATGAACGAC
ACCCTGTTCTCCCACTCTGTTCCCTCCTCAGGAAGTCCTTTTATTACCAGGAGCTCTCCTCCCAAGGACAGTGAAGTAGAGCAGAACAAACTGCTGGCTA
GGGCTGCTCCAGCTTTTCTGAAGGGCAAAGGGATACAGTACAGCCTGAATGTGGCAGACAGGCTAGCTGATGAACATGTTCTCATCGGGTTGTATGTCAA
CATGCTCCGGAACAACCCCTCATG
CATGCTTGAGAGTTCAAACCGGCTTGATGAAGAACACAGGCTAATTGCCAGGTATGCGGCAAGGCTGGCAGCAGAG
TCCTCTTCGTCTCAGCCACCTCAGCAGAGAAGTGCTCCTGACATCTCTTTCACCATCGATGCGAATAAGCAGCAAAGGCAGCTGATTGCTGAGCTAGAAA
ACAAGAACAGAGAAATCTTACAGGAGATCCAGAGACTTCGGCTAGAGCATGAACAAGCTTCTCAGCCCACGCCAGAGAAGGCACAGCAAAACCCCACCCT
GCTGGCAGAACTCCGGCTCCTCAGACAGCGCAAAGATGAGCTGGAACAGAGAATGTCTGCTCTCCAGGAGAGCCGGAGAGAGCTAATGGTCCAGTTGGAG
GGTCTCATGAAGCTACTAAAGGAAGAAGAACTGAAGCAGGGAGTAAGTTATGTCCCCTACTGCAGGTCTTAACTAACAGTGGAGGGGCCTGCCGACCTGC
GGTTTTCTCATTGCTTTTGCTCTAATGTATGTTCATGCTTCAGTTTGGAAAGAGAAAAAAGTCATACTAATTTGCTTCTTTTTCAATGTAGTGCTTGAAT
TGAGATATATAAATTTAGCATTTTTTATAACTATCACTACTATCCACATCAAAAGAAGAACTATGACATCTTTTAGAAAAGGGAACGAATTGTCATTTAT
TGGAAACATTTTAGATCCCCAGAGGTATAAGTTTCAAACCAGTCTTAGCTTTTCAAGTTGTTGATCAGACCCTTCTCTTAACAGAGAGATACCACAGTCA
CTAGAGATACCCTGAGGTTCATGTCATCCCAAAACCCACAGCACTCAGAAGCTAACCTCTACACCCACTCACACTGTGAGTATTCAGTTCGGTTTCATTT
TACTGAAAACCTGTGAAACCTCTTTTTATAAAAATCAGGCAATTAAATCCCTTTTCATCACACAATTATTGAGCCTTGTTCCCCATGGCTCACCAAAATG
TGCTCAATTTTGTGAGAGAAAGACTGTACTCCATAACTGACTATTCACGTCCCATCTTTTTGGCTCTTCCCCAAAGCAGAATCCTTACTGTTGGTTGACA
GTAATCTCTTTTTAAAAAGTAACTCTCAGCTTTTTCCTTAGCACCAGAGCCTTTCGGCTCCGGGAGACGAGAGGGTCATTACATACTTTTTTTTTTTTCT
GGAAATAGGGGCATTGTGACTTTATAGCCTAAACTGGAGCTGTCTGAACCTGTGGTCAGGCTCAAGAGCCAGCAGGGGGAGCAGCAAACTCAAAAAAAAA
AACAAATTAAATTAAATTAAATTAAATTAAATAGAAGCAAAATAAAAGCAGCTTTAATTTCAAGTGCATGTACCACGCTATGTATGACAATATATCCCAC
TCACTAGCATTATTTAAAAGTTTCACATTATTTCCATGGATCAATTAGAACCACAACCTGTCCAATTTCAACGTATCTTTCATTTCTTCTGTATGCTCTT
TTCTATTATTCATTATGTGTGTTTGTGTGTAACAAAGAATGTTTGGAAAATGCTGGACACATTTTTACCCTTCATTCCCATGGTCTGTAAAAAAGGAAAG
TGTAAAATCAATCTGTAATGTCAGACAATAAAGATAATGTATTACATTATTTTGTATTTTGTGAAAAAAATTACTTTACTAAATTAAAGTCAAATTTTAA
CAGAAGACAGTCCCCC
  • refseq_DTNA.F4 (forward primer)
  • refseq_DTNA.R1 (reverse primer)
  • Single exon skipping

Frame 0

DCCVLSTRGRMNTAFY*S*RLLWSLFGNV*GQI
L*FSAYVVLQRKN*GACWCI*LQNQVAGCCSLLQ
NPALRKAKEENRTSECVTEND*R*WEKRKYHGR
KKTAVCRDEGSRSGSHPTLHLQNSMQA*VCSEE
MQFAPGGHMECHRSIAGKCSEQPGPKH*TQRVPL
RGCALHYFLPAQQTDANHSPNPCGAVHQPPP*L
PACSV*SGRPW*NFSICCQNGFSHIVWREDHGQ
IKIYFLNDF*LQWGDGLWTI*PIPSGSSQTTHGS
F*RSFIWLHRTVSQILFLPTEKSHVKWFLGHAY
VRSSPAVSGLVASSASTSKCGKCLPSG*VFLLP
Q*EYDGISLPMPTVSQLPALSGLLLEGTCRWFS*
QPAPNERVHVMEITC*EAD*CIKQVPELCFQP*
TFAPHVPRSA*EATQLGSHR*YLASQTCNQHER
HPVLPLCSLLRKSFYYQELSSQGQ*SRAEQTAG*
GCSSFSEGQRDTVQPECGRQAS**TCSHRVVCQ
HAPEQPLM
HA*EFKPA**RTQANCQVCGKAGSR
VLFVSATSAEKCS*HLFHHRCE*AAKAADC*ARK
QEQRNLTGDPETSARA*TSFSAHAREGTAKPHP
AGRTPAPQTAQR*AGTENVCSPGEPERANGPVG
GSHEATKGRRTEAGSKLCPLLQVLTNSGGACRPA
VFSLLLL*CMFMLQFGKRKKSY*FASFSM*CLN
*DI*I*HFL*LSLLSTSKEEL*HLLEKGTNCHL
LETF*IPRGISFKPVLAFQVVDQTLLLTERYHSH
*RYPEVHVIPKPTALRS*PLHPLTL*VFSSVSF
Y*KPVKPLFIKIRQLNPFSSHNY*ALFPMAHQN
VLNFVRERLYSITDYSRPIFLALPQSRILTVG*Q
*SLFKK*LSAFSLAPEPFGSGRREGHYILFFFS
GNRGIVTL*PKLELSEPVVRLKSQQGEQQTQKK
KQIKLN*IKLNRSKIKAALISSACTTLCMTIYPT
H*HYLKVSHYFHGSIRTTTCPISTYLSFLLYAL
FYYSLCVFVCNKECLENAGHIFTLHSHGL*KRK
V*NQSVMSDNKDNVLHYFVFCEKNYFTKLKSNFN
RRQSP

Frame 1

IAVC*AQGEE*TQLFIEVKGYFGVCLEMCKVKY
YSFQHM*YFRGRIKGHVGAFNYKTRWQVAALSF
RTPL*GKLRKRTGRLSV*LRMIEDSGKRGNTMAE
RRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKK
CNLHLVDIWNVIEALRENALNNLDPNTELNVSR
LEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNF
LLAAFDPEGHGKISVFAVKMALATLCGGKIMDK
LRYIFSMISDSSGVMVYGRYDQFLREVLKLPTA
VFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLM
SDPPPQCLVWLPLLHRLANVENVFHPVECSYCH
SESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSH
SNQHQMKEYTSWKSPAKKLTNALSKSLSCASSRE
PLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMND
TLFSHSVPSSGSPFITRSSPPKDSEVEQNKLLA
RAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVN
MLRNNPSC
MLESSNRLDEEHRLIARYAARLAAE
SSSSQPPQQRSAPDISFTIDANKQQRQLIAELE
NKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLE
GLMKLLKEEELKQGVSYVPYCRS*LTVEGPADL
RFSHCFCSNVCSCFSLEREKSHTNLLLFQCSA*I
EIYKFSIFYNYHYYPHQKKNYDIF*KRERIVIY
WKHFRSPEV*VSNQS*LFKLLIRPFS*QRDTTV
TRDTLRFMSSQNPQHSEANLYTHSHCEYSVRFHF
TENL*NLFL*KSGN*IPFHHTIIEPCSPWLTKM
CSIL*EKDCTP*LTIHVPSFWLFPKAESLLLVD
SNLFLKSNSQLFP*HQSLSAPGDERVITYFFFFL
EIGAL*LYSLNWSCLNLWSGSRASRGSSKLKKK
NKLN*IKLN*IEAK*KQL*FQVHVPRYV*QYIP
LTSII*KFHIISMDQLEPQPVQFQRIFHFFCMLF
SIIHYVCLCVTKNVWKMLDTFLPFIPMVCKKGK
CKINL*CQTIKIMYYIILYFVKKITLLN*SQIL
TEDSP

Frame 2

LLCVEHKGKNEHSFLLKLKVTLEFVWKCVRSNT
IVFSICSTSEEELRGMLVHLTTKPGGRLLLSPS
EPRSEES*GREQDV*VCD*E*LKIVGKEEIPWQ
KEDSCLQR*GLKIWIASDSPPTEQHASLGLFRRN
AICTWWTYGMS*KHCGKML*TTWTQTLNSTCPA
*RLCSPLFFTSSTNGCQPLTKSMWSSPSASSLT
SCLQRLIRKAMVKFQYLLSKWL*PHCVEGRSWTN
*DIFSQ*FLTPVG*WFMDDMTNSFGKFSNYPRQ
FLKVLHLVTQNSQPDPVSPNRKKSR*MVSWTRL
CQILPRSVWSGCLFCID*QMWKMSSIRLSVPTAT
VRV*WDFATDANSVTITSSVRTASGGDMPVVLI
ATSTK*KSTRHGNHLLRS*LMH*ASP*AVLPAV
NLCTPCSQISLRSHSTWLTSLILGLPDL*PA*TT
PCSPTLFPPQEVLLLPGALLPRTVK*SRTNCWL
GLLQLF*RAKGYSTA*MWQTG*LMNMFSSGCMS
TCSGTTPH
ACLRVQTGLMKNTG*LPGMRQGWQQS
PLRLSHLSREVLLTSLSPSMRISSKGS*LLS*K
TRTEKSYRRSRDFG*SMNKLLSPRQRRHSKTPP
CWQNSGSSDSAKMSWNRECLLSRRAGES*WSSWR
VS*SY*RKKN*SRE*VMSPTAGLN*QWRGLPTC
GFLIAFALMYVHASVWKEKKVILICFFFNVVLE
LRYINLAFFITITTIHIKRRTMTSFRKGNELSFI
GNILDPQRYKFQTSLSFSSC*SDPSLNREIPQS
LEIP*GSCHPKTHSTQKLTSTPTHTVSIQFGFI
LLKTCETSFYKNQAIKSLFITQLLSLVPHGSPKC
AQFCERKTVLHN*LFTSHLFGSSPKQNPYCWLT
VISF*KVTLSFFLSTRAFRLRETRGSLHTFFFF
WK*GHCDFIA*TGAV*TCGQAQEPAGGAANSKKK
TN*IKLN*IK*KQNKSSFNFKCMYHAMYDNISH
SLALFKSFTLFPWIN*NHNLSNFNVSFISSVCS
FLLFIMCVCV*QRMFGKCWTHFYPSFPWSVKKES
VKSICNVRQ*R*CITLFCIL*KKLLY*IKVKF*
QKTVP

Sequence NM_032978

GATTGCTGTGTGTTGAGCACAAGGGGAAGAATGAACACAGCTTTTTATTGAAGTTAAAGGTTACTTTGGAGTTTGTTTGGAAATGTGTAAGGTCAAATAC
TATAGTTTTCAGCATATGTAGTACTTCAGAGGAAGAATTAAGGGGCATGTTGGTGCATTTAACTACAAAACCAGAATGATTGAAGATAGTGGGAAAAGAG
GAAATACCATGGCAGAAAGAAGACAGCTGTTTGCAGAGATGAGGGCTCAAGATCTGGATCGCATCCGACTCTCCACCTACAGAACAGCATGCAAGCTTAG
GTTTGTTCAGAAGAAATGCAATTTGCACCTGGTGGACATATGGAATGTCATAGAAGCATTGCGGGAAAATGCTCTGAACAACCTGGACCCAAACACTGAA
CTCAACGTGTCCCGCTTAGAGGCTGTGCTCTCCACTATTTTTTACCAGCTCAACAAACGGATGCCAACCACTCACCAAATCCATGTGGAGCAGTCCATCA
GCCTCCTCCTTAACTTCCTGCTTGCAGCGTTTGATCCGGAAGGCCATGGTAAAATTTCAGTATTTGCTGTCAAAATGGCTTTAGCCACATTGTGTGGAGG
GAAGATCATGGACAAATTAAGATATATTTTCTCAATGATTTCTGACTCCAGTGGGGTGATGGTTTATGGACGATATGACCAATTCCTTCGGGAAGTTCTC
AAACTACCCACGGCAGTTTTTGAAGGTCCTTCATTTGGTTACACAGAACAGTCAGCCAGATCCTGTTTCTCCCAACAGAAAAAAGTCACGTTAAATGGTT
TCTTGGACACGCTTATGTCAGATCCTCCCCCGCAGTGTCTGGTCTGGTTGCCTCTTCTGCATCGACTAGCAAATGTGGAAAATGTCTTCCATCCGGTTGA
GTGTTCCTACTGCCACAGTGAGAGTATGATGGGATTTCGCTACCGATGCCAACAGTGTCACAATTACCAGCTCTGTCAGGACTGCTTCTGGAGGGGACAT
GCCGGTGGTTCTCATAGCAACCAGCACCAAATGAAAGAGTACACGTCATGGAAATCACCTGCTAAGAAGCTGACTAATGCATTAAGCAAGTCCCTGAGCT
GTGCTTCCAGCCGTGAACCTTTGCACCCCATGTTCCCAGATCAGCCTGAGAAGCCACTCAACTTGGCTCACATCGTGCCTCCCAGACCTGTAACCAGCAT
GAACGACACCCTGTTCTCCCACTCTGTTCCCTCCTCAGGAAGTCCTTTTATTACCAGGAGCTCTCCTCCCAAGGACAGTGAAGTAGAGCAGAACAAACTG
CTGGCTAGGGCTGCTCCAGCTTTTCTGAAGGGCAAAGGGATACAGTACAGCCTGAATGTGGCAGACAGGCTAGCTGATGAACATGTTCTCATCGGGTTGT
ATGTCAACATGCTCCGGAACAACCCCTCATG
CATGCTTGAGAGTTCAAACCGGCTTGATGAAGAACACAGGCTAATTGCCAGGTATGCGGCAAGGCTGGC
AGCAGAGTCCTCTTCGTCTCAGCCACCTCAGCAGAGAAGTGCTCCTGACATCTCTTTCACCATCGATGCGAATAAGCAGCAAAGGCAGCTGATTGCTGAG
CTAGAAAACAAGAACAGAGAAATCTTACAGGAGATCCAGAGACTTCGGCTAGAGCATGAACAAGCTTCTCAGCCCACGCCAGAGAAGGCACAGCAAAACC
CCACCCTGCTGGCAGAACTCCGGCTCCTCAGACAGCGCAAAGATGAGCTGGAACAGAGAATGTCTGCTCTCCAGGAGAGCCGGAGAGAGCTAATGGTCCA
GTTGGAGGGTCTCATGAAGCTACTAAAGGAAGAAGAACTGAAGCAGGGAGTAAGTTATGTCCCCTACTGCAGGTCTTAACTAACAGTGGAGGGGCCTGCC
GACCTGCGGTTTTCTCATTGCTTTTGCTCTAATGTATGTTCATGCTTCAGTTTGGAAAGAGAAAAAAGTCATACTAATTTGCTTCTTTTTCAATGTAGTG
CTTGAATTGAGATATATAAATTTAGCATTTTTTATAACTATCACTACTATCCACATCAAAAGAAGAACTATGACATCTTTTAGAAAAGGGAACGAATTGT
CATTTATTGGAAACATTTTAGATCCCCAGAGGTATAAGTTTCAAACCAGTCTTAGCTTTTCAAGTTGTTGATCAGACCCTTCTCTTAACAGAGAGATACC
ACAGTCACTAGAGATACCCTGAGGTTCATGTCATCCCAAAACCCACAGCACTCAGAAGCTAACCTCTACACCCACTCACACTGTGAGTATTCAGTTCGGT
TTCATTTTACTGAAAACCTGTGAAACCTCTTTTTATAAAAATCAGGCAATTAAATCCCTTTTCATCACACAATTATTGAGCCTTGTTCCCCATGGCTCAC
CAAAATGTGCTCAATTTTGTGAGAGAAAGACTGTACTCCATAACTGACTATTCACGTCCCATCTTTTTGGCTCTTCCCCAAAGCAGAATCCTTACTGTTG
GTTGACAGTAATCTCTTTTTAAAAAGTAACTCTCAGCTTTTTCCTTAGCACCAGAGCCTTTCGGCTCCGGGAGACGAGAGGGTCATTACATACTTTTTTT
TTTTTCTGGAAATAGGGGCATTGTGACTTTATAGCCTAAACTGGAGCTGTCTGAACCTGTGGTCAGGCTCAAGAGCCAGCAGGGGGAGCAGCAAACTCAA
AAAAAAAAACAAATTAAATTAAATTAAATTAAATTAAATAGAAGCAAAATAAAAGCAGCTTTAATTTCAAGTGCATGTACCACGCTATGTATGACAATAT
ATCCCACTCACTAGCATTATTTAAAAGTTTCACATTATTTCCATGGATCAATTAGAACCACAACCTGTCCAATTTCAACGTATCTTTCATTTCTTCTGTA
TGCTCTTTTCTATTATTCATTATGTGTGTTTGTGTGTAACAAAGAATGTTTGGAAAATGCTGGACACATTTTTACCCTTCATTCCCATGGTCTGTAAAAA
AGGAAAGTGTAAAATCAATCTGTAATGTCAGACAATAAAGATAATGTATTACATTATTTTGTATTTTGTGAAAAAAATTACTTTACTAAATTAAAGTCAA
ATTTTAACAGAAGACAGTCCCCC
  • refseq_DTNA.F4 (forward primer)
  • refseq_DTNA.R1 (reverse primer)
  • Single exon skipping

Frame 0

DCCVLSTRGRMNTAFY*S*RLLWSLFGNV*GQI
L*FSAYVVLQRKN*GACWCI*LQNQND*R*WEKR
KYHGRKKTAVCRDEGSRSGSHPTLHLQNSMQA*
VCSEEMQFAPGGHMECHRSIAGKCSEQPGPKH*
TQRVPLRGCALHYFLPAQQTDANHSPNPCGAVHQ
PPP*LPACSV*SGRPW*NFSICCQNGFSHIVWR
EDHGQIKIYFLNDF*LQWGDGLWTI*PIPSGSS
QTTHGSF*RSFIWLHRTVSQILFLPTEKSHVKWF
LGHAYVRSSPAVSGLVASSASTSKCGKCLPSG*
VFLLPQ*EYDGISLPMPTVSQLPALSGLLLEGT
CRWFS*QPAPNERVHVMEITC*EAD*CIKQVPEL
CFQP*TFAPHVPRSA*EATQLGSHRASQTCNQH
ERHPVLPLCSLLRKSFYYQELSSQGQ*SRAEQT
AG*GCSSFSEGQRDTVQPECGRQAS**TCSHRVV
CQHAPEQPLM
HA*EFKPA**RTQANCQVCGKAG
SRVLFVSATSAEKCS*HLFHHRCE*AAKAADC*
ARKQEQRNLTGDPETSARA*TSFSAHAREGTAKP
HPAGRTPAPQTAQR*AGTENVCSPGEPERANGP
VGGSHEATKGRRTEAGSKLCPLLQVLTNSGGAC
RPAVFSLLLL*CMFMLQFGKRKKSY*FASFSM*C
LN*DI*I*HFL*LSLLSTSKEEL*HLLEKGTNC
HLLETF*IPRGISFKPVLAFQVVDQTLLLTERY
HSH*RYPEVHVIPKPTALRS*PLHPLTL*VFSSV
SFY*KPVKPLFIKIRQLNPFSSHNY*ALFPMAH
QNVLNFVRERLYSITDYSRPIFLALPQSRILTV
G*Q*SLFKK*LSAFSLAPEPFGSGRREGHYILFF
FSGNRGIVTL*PKLELSEPVVRLKSQQGEQQTQ
KKKQIKLN*IKLNRSKIKAALISSACTTLCMTI
YPTH*HYLKVSHYFHGSIRTTTCPISTYLSFLLY
ALFYYSLCVFVCNKECLENAGHIFTLHSHGL*K
RKV*NQSVMSDNKDNVLHYFVFCEKNYFTKLKS
NFNRRQSP

Frame 1

IAVC*AQGEE*TQLFIEVKGYFGVCLEMCKVKY
YSFQHM*YFRGRIKGHVGAFNYKTRMIEDSGKR
GNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLR
FVQKKCNLHLVDIWNVIEALRENALNNLDPNTE
LNVSRLEAVLSTIFYQLNKRMPTTHQIHVEQSI
SLLLNFLLAAFDPEGHGKISVFAVKMALATLCGG
KIMDKLRYIFSMISDSSGVMVYGRYDQFLREVL
KLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNG
FLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVE
CSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGH
AGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLS
CASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSM
NDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKL
LARAAPAFLKGKGIQYSLNVADRLADEHVLIGL
YVNMLRNNPSC
MLESSNRLDEEHRLIARYAARLA
AESSSSQPPQQRSAPDISFTIDANKQQRQLIAE
LENKNREILQEIQRLRLEHEQASQPTPEKAQQN
PTLLAELRLLRQRKDELEQRMSALQESRRELMVQ
LEGLMKLLKEEELKQGVSYVPYCRS*LTVEGPA
DLRFSHCFCSNVCSCFSLEREKSHTNLLLFQCS
A*IEIYKFSIFYNYHYYPHQKKNYDIF*KRERIV
IYWKHFRSPEV*VSNQS*LFKLLIRPFS*QRDT
TVTRDTLRFMSSQNPQHSEANLYTHSHCEYSVR
FHFTENL*NLFL*KSGN*IPFHHTIIEPCSPWLT
KMCSIL*EKDCTP*LTIHVPSFWLFPKAESLLL
VDSNLFLKSNSQLFP*HQSLSAPGDERVITYFF
FFLEIGAL*LYSLNWSCLNLWSGSRASRGSSKLK
KKNKLN*IKLN*IEAK*KQL*FQVHVPRYV*QY
IPLTSII*KFHIISMDQLEPQPVQFQRIFHFFC
MLFSIIHYVCLCVTKNVWKMLDTFLPFIPMVCKK
GKCKINL*CQTIKIMYYIILYFVKKITLLN*SQ
ILTEDSP

Frame 2

LLCVEHKGKNEHSFLLKLKVTLEFVWKCVRSNT
IVFSICSTSEEELRGMLVHLTTKPE*LKIVGKE
EIPWQKEDSCLQR*GLKIWIASDSPPTEQHASL
GLFRRNAICTWWTYGMS*KHCGKML*TTWTQTLN
STCPA*RLCSPLFFTSSTNGCQPLTKSMWSSPS
ASSLTSCLQRLIRKAMVKFQYLLSKWL*PHCVE
GRSWTN*DIFSQ*FLTPVG*WFMDDMTNSFGKFS
NYPRQFLKVLHLVTQNSQPDPVSPNRKKSR*MV
SWTRLCQILPRSVWSGCLFCID*QMWKMSSIRL
SVPTATVRV*WDFATDANSVTITSSVRTASGGDM
PVVLIATSTK*KSTRHGNHLLRS*LMH*ASP*A
VLPAVNLCTPCSQISLRSHSTWLTSCLPDL*PA
*TTPCSPTLFPPQEVLLLPGALLPRTVK*SRTNC
WLGLLQLF*RAKGYSTA*MWQTG*LMNMFSSGC
MSTCSGTTPH
ACLRVQTGLMKNTG*LPGMRQGW
QQSPLRLSHLSREVLLTSLSPSMRISSKGS*LLS
*KTRTEKSYRRSRDFG*SMNKLLSPRQRRHSKT
PPCWQNSGSSDSAKMSWNRECLLSRRAGES*WS
SWRVS*SY*RKKN*SRE*VMSPTAGLN*QWRGLP
TCGFLIAFALMYVHASVWKEKKVILICFFFNVV
LELRYINLAFFITITTIHIKRRTMTSFRKGNEL
SFIGNILDPQRYKFQTSLSFSSC*SDPSLNREIP
QSLEIP*GSCHPKTHSTQKLTSTPTHTVSIQFG
FILLKTCETSFYKNQAIKSLFITQLLSLVPHGS
PKCAQFCERKTVLHN*LFTSHLFGSSPKQNPYCW
LTVISF*KVTLSFFLSTRAFRLRETRGSLHTFF
FFWK*GHCDFIA*TGAV*TCGQAQEPAGGAANS
KKKTN*IKLN*IK*KQNKSSFNFKCMYHAMYDNI
SHSLALFKSFTLFPWIN*NHNLSNFNVSFISSV
CSFLLFIMCVCV*QRMFGKCWTHFYPSFPWSVK
KESVKSICNVRQ*R*CITLFCIL*KKLLY*IKVK
F*QKTVP

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