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Sequences

Sequence NM_001012957

GGAAGGAGCAGGAGGCAGCCCAGGCGGAGCGGGAGGAGCTGGCAGCGGGGCGCATGCCAGGCGGGGGTCCTCAGGGCGCCCCAGCCGCCGCCGGCGGCGG CGGCGTGAGCCACCGCGCAGGCAGCCGGGATTGCTTACCACCTGCAGCGTGCTTTCGGAGGCGGCGGCTGGCACGGAGGCCGGGCTACATGAGAAGCTCG ACAGGGCCTGGGATCGGGTTCCTTTCCCCAGCAGTGGGCACACTGTTCCGGTTCCCAGGAGGGGTGTCTGGCGAGGAGTCCCACCACTCGGAGTCCAGGG CCAGACAGTGTGGCCTTGACTCGAGAGGCCTCTTGGTCCGGAGCCCTGTTTCCAAGAGTGCAGCAGCCCCTACTGTGACCTCTGTGAGAGGAACCTCGGC GCACTTTGGGATTCAGCTCAGAGGTGGCACCAGATTGCCTGACAGGCTTAGCTGGCCGTGTGGCCCTGGGAGTGCTGGGTGGCAGCAAGAGTTTGCAGCC ATGGATAGTTCTGAGACCCTGGACGCCAGCTGGGAGGCAGCCTGCAGCGATGGAGCAAGGCGTGTCCGGGCAGCAGGCTCTCTGCCATCAGCAGAGTTGA GTAGCAACAGCTGCAGCCCTGGCTGTGGCCCTGAGGTCCCCCCAACCCCTCCTGGCTCTCACAGTGCCTTTACCTCAAGCTTTAGCTTTATTCGGCTCTC GCTTGGCTCTGCCGGGGAACGTGGAGAAGCAGAAGGCTGCCCACCATCCAGAGAGGCTGAGTCCCATTGCCAGAGCCCCCAGGAGATGGGAGCCAAAGCT GCCAGCTTGGACGGGCCTCACGAGGACCCGCGATGTCTCTCTCGGCCCTTCAGTCTCTTGGCTACACGGGTCTCTGCAGACTTGGCCCAGGCCGCAAGGA ACAGCTCCAGGCCAGAGCGTGACATGCATTCTTTACCAGACATGGACCCTGGCTCCTCCAGTTCTCTGGATCCCTCACTGGCTGGCTGTGGTGGTGATGG GAGCAGCGGCTCAGGGGATGCCCACTCTTGGGACACCCTGCTCAGGAAATGGGAGCCAGTGCTGCGGGACTGCCTGCTGAGAAACCGGAGGCAGATGGAG GTAATATCCTTAAGATTAAAACTTCAGAAACTTCAGGAAGATGCAGTTGAGAATGATGATTATGATAAAGCTGAGACGTTACAACAAAGATTAGAAGACC TGGAACAAGAGAAAATCAGCCTGCACTTTCAACTTCCTTCAAGGCAGCCAGCTCTTAGCAGTTTCCTGGGTCACCTGGCAGCACAAGTCCAGGCTGCCTT GCGCCGTGGGGCCACTCAGCAGGCCAGCGGAGATGACACCCACACCCCACTGAGAATGGAGCCGAGGCTGTTGGAACCCACTGCTCAGGACAGCTTGCAC GTGTCCATCACGAGACGAGACTGGCTTCTTCAGGAAAAGCAGCAGCTACAGAAAGAAATCGAAGCTCTCCAAGCAAGGATGTTTGTGCTGGAAGCCAAAG ATCAACAGCTGAGAAGGGAAATAGAGGAGCAAGAGCAGCAACTCCAGTGGCAGGGCTGCGACCTGACCCCACTGGTGGGCCAGCTGTCCCTGGGTCAGCT GCAGGAGGTCAGCAAGGCCTTGCAGGACACCCTGGCCTCAGCCGGTCAGATTCCCTTCCATGCAGAGCCACCGGAAACCATAAGGAGCCTCCAGGAAAGA ATAAAATCCCTCAACTTGTCACTTAAAGAAATCACTACTAAGGTGTGTATGAGTGAGAAATTCTGCAGCACCCTGAGGAAGAAAGTTAACGATATTGAAA CCCAACTACCAGCCTTGCTTGAAGCCAAAATGCATGCCATATCAGGAAACCATTTCTGGACGGCTAAAGACCTCACCGAGGAGATTAGATCATTAACATC AGAGAGAGAAGGGCTGGAGGGACTCCTCAGCAAGCTGTTGGTGTTGAGTTCCAGGAATGTCAAAAAGCTGGGAAGTGTTAAAGAAGATTACAACAGACTG AGAAGAGAAGTGGAGCACCAGGAGACTGCCTATGAAACAAGTGTGAAGGAAAATACTATGAAGTACATGGAAACACTTAAGAATAAACTGTGCAGCTGCA AGTGTCCACTGCTTGGGAAAGTGTGGGAAGCTGACTTGGAAGCTTGTCGATTGCTTATCCAGAGCCTACAGCTCCAGGAAGCCAGGGGAAGCCTGTCTGT AGAAGATGAGAGGCAGATGGATGACTTAGAGGGAGCTGCTCCTCCTATTCCCCCCAGGCTCCACTCCGAGGATAAAAGGAAGACCCCTTTGAAGGAATCT TACATCCTTTCTGCAGAACTTGGAGAAAAGTGTGAAGACATAGGCAAGAAGCTATTGTACTTGGAAGATCAACTTCACACAGCAATCCACAGTCATGATG AAGATCTCATTCAGTCTCTCAGGAGGGAGCTCCAGATGGTGAAGGAAACTCTGCAGGCCATGATCCTGCAGCTCCAGCCAGCAAAGGAGGCGGGAGAAAG AGAAGCTGCAGCTTCCTGCATGACAGCTGGTGTCCACGAAGCACAAGCCTGAGGAGTGACGGGATGGGGGAGGGAGGTGGGCCACCATGTTTGGACCCGG GGGGCTGCTCTTCCCTCCCCCGCCATAGCTAAGATGCCTGAATCAATTACGGAGATACAGAGCCTTGAGGTCTTTCAGTGGAAAGGTGGTTCATGTTCAT TCTCATCAGTGTGAAACTGAGGAGTCTGCAATTTGGAATATGGAGAGAGAGACTGATTTGCTGAATTTCCTTCTAAATGTCACTCAAAAATTTCTTTTCC ATGTCATTCTTGGGAATGTCTTCCACAGGATTTGAGAATAGTTTCATCTCAGCCCCCATTAGAGAGAAGTTGGGGTGAATTCTGGAAAAATGTCTCTTTT TCCTGTGCCATTTGCCTTCTGCTGCAACGAAAATATTTCCTGATTCAAGATTCTATAAAAAGGAAACCAAGCATAAGACTCTGTCATCATACCTGTTACA CGTTCCTACAGGTGCACAATCTAAGAGAGCTAATTAACCTCAGAGTCTGGAGTTAACAGCTTTTCACCTTACTTCTCCTGTGATCTAATATTATCTTAGA AAAATTAATATGCAATTTCCAAAAGATATTTTGGTAAGACAACAACCTCCCAGTGATATGCCACCTTTCAATTTTCCTTTTGTGGCAATGATTGCATCTG AAGAAAGGATCCCTGAGAGTCTCTGTTTCATCAGGACATTCTGAAATTTACCCACAGTGAGGCTGTGGATGGATCAGGGGACCTGTATAAAATGTTTGAG CCTGTTCCATTTTCCCGTGGAACCTGTTTCACTCAATGCCAGGCAGTGCAGCATTTAGGAAAGCAGTGCAGTACTCAGTAAGGCAGTGCAGTACTCAGTA ACACAATACAGTACTCAGGCAGTGCAGTACTCAGTAAGACAGTGCAGTGCTCAGTAAGGCAGTGCAATACTCAGTAACAGTGTAGTACTCAGTAACAGTG AAGTACTCAGTAATACAGTACAGTATTCAGTAAGGCAGTGAAGTACTCAGTAATACAATACAGTACTCAGTTAGGCAGTGCAGTACTCAGGAATGCAGCA CAGTACTCAGGCAGTGCAATACTCAGTGCGGTACTCAGTAACACAGTGCAGTACTCAGTAACAGTGCAGTACTCAGTAACAGTGCAGTACTCAGTAAGGC AGTGCAGTACTCAGTAACACAGTGCAGTACTCAGTAATACAGTACAGTACTCAGTAAGGCAGTATGGTACTCAGTAAAGCAATGCAATGCTCAGTAACAC AGTGCAGTGCTCAATAAGGCAGTGCAGTGCTCAGTAAGGCAGTGAATTGCTTAGTAACACAGTGTAGTGCTCAGTAGGACAGCATAGTACTCAGTAACAC AGGGCAGCTAGTACTCAGTACTATAAGTACTGAGTACTTATATAGGCAATGTAGTACTCAGTAAATCAGTGCAGTACTCAGTAATGCAAGGGCATTTCAG GCTCCTGCTGGGCTGCTTCTTTGGCCCAGCTGGGACTCCTATTGAGACAGCTGCAAAACAGGCTGATTTCAATTAGGCAGCACTTCCCAAAGTGCACTGA GGAAGGTGGCCCCAAGAGAAGCTCTCTAAACAAAGGAGTACCCTCTCTGGTCAAGTACCTTTGGTAAATACACCATACCATAATATCTGCTTGGAGAACC ACAATGCACATTAGCATATTAGTCTGAGAGAGAACTTATAGTAAGGAAACTCACTTGATTTTATCTAACCTCAAACTTTCCAAGTTTAATGGATCGTGAA TTTTTTTCATGTAACTCCTATTCATATCCCATAGATCTAGTATTGTACAGCACTGCATTCTCTGAGGAAGTCCCAGTCCAAACTCTGATTTACATCACTT TAGAAACCACACTCACACTTTTGCAGAGTGTTGAGCTTAATAACTACCTGCCACAGATTGGTAAATTTAATCCAGTGGTTGTTCTGTTTGTGCTTCTGTT CTCATTTATGTGTTTAGGGATAGTGAGGTTCCTGCCTTCACTAGGATCCACGGATATGAGACCATTTTTGTCATTTCCTGAAGTCACACTGGCGTTTCCA GAAGGCATCTGGTGCTTTGCTCAGCCTTCCATGCTGTGCAGCACTTCTGTCCTCAGTCAAGGAGATGGCCATGCTTAAGCCAGCAATTGGCTGGGGTCCA GGAAACAAAGCAAAAGCACAATATGTGAATGTGCTGATTGTGTTCCCTATGGCTTTATCTCGAGCAAAATACACTCTACATATTTTAATAATAAGTATAA TTAGCTTGTTCCTGGACTTCATTTTCAATGATGAACCAAATTCCTGAATTATTTATAATTGTGTCTAAAGAAAATTATGAACTGGTCACATGGCACTTGG AATCCTTGAGTTAATTCCAGTGAAGCAAAACTTGGGAAGAGTCAGGATTGGCCACATTGCCAATAACAAATTCCTACTTCGACATATGTCTTTTCAAAAA GCCTCCCAGACACAAGACATCTTAACCGTCACTAGCCCAAGTGTTTTGTATTACTCAGACACCATCATGAAATAATTCTGTGAGGTCATGATGTATTTGA AAATTCTGCAAGTTAATAACTGCCTTGAATTGTTTGAACCCGAAATAAGGGTTCTTTGGTACCTCTAGTAGATAGTGTGTTCATTTCCCTGCTGCAAATT TTGAAGTATTTGGGCAGGTGAGTCATGTTTTAACCACAAGCCATAACTCATCTGTTGTCTTTGCTTGGTCTTAGAGTATCATTCAGAAAGTCCGCTAAGG GCCAGCGTGCTTCTTCTGGCTACACAACCTTCTCAGGACAAGCCCACTGTCTTAAGCCACTTTGACCCTGGGAGACACAGGACTGTGTATCCTCAATCAT ACTATACAGCAGTTTTTGTCAGGGGAACATAAAAATATCCAAGAGAGGTTAGGGCTTAGATTTAAAAGCATCAAAACAACAACAATGGAAATTTATGTTG GCGATAGCCAAGACCACAAGCAAAAGCACATACTGGAAATGATGAGTTAGAATCTGATTTGACTGGGATGTTTTATGAGAATGTAAGTGTGATATTATAC TGTCTGCCTTGCTGGAATGCTGGCTTTCAAATGGTCACCCATTTTTCTTTCACTGGCCTGAGTTAGGACATGCTATCAGTAATAGTCCCAGTTCCATCCA ACTTTCTGAAATTTCATTTTTTTTTTTGAGATGGAGTCTCTCTCTGTCACCCAAGTTGGAGTGCAGTGGCCCCGCAATCTCGGCTCACTGCAACCTCTAC CTCCCAGGTTCAAGCTATTCTACTGCCTCAGCCTCCCAAGTAGCTGGGGTTACAGGCATTTGCCACCGGGCCCTGATGATTTTTGTATTTTTAGTAGAGA CAGGGCTTCACCATGTTGGCTAGGAGGGTCTCAAACTCCTGACCTCAGGCGATCCACCCCCACCTCGGCTTCCCAAAGTGCTGAGATTACAGGTGTGAGC CACCGCACCCGGCCAACTTTCTGAAATTTCAAAACTGAATTGATCCTTCTCCAAATTAGTATATACTATTGGAAACTTGTCTTTCCCTGCAGTAAGGCTG GTTTCCCCACCCCAGAAACATGTAACGGTTGGTACCATGCTAAGCCCTTGCCATGCTAAGCCCTTTACAGTCATATCCTATAATCCCCATATCAACCTTA TAAGGAAGGTGTTTGTAGATGATGCAACTGAGCCTTAAGAGGACTAATTCCCTTTTTCTAAGGCACAGAGCTGGTAAAATGTGAAGTAATAGTGAACCTA ACAGTCAGAGACAGGCAGCATGCTCTTAACTAGTGCTCTTCCTAAAGTTCCTTTAATGTCCTTTTGAGATTTTGAGCCATGGAACTTACTTGTTCACCTG GCTAAGAACTCATGGCCACTGTGGAAATCTTGGTTAGGGAGTCAAAGAAACTGAGCCTGGGGCAAACGAGGCTTCCCACACTGCCAGGGGAGCCTCACTG TGAAGTCTAGGCTCAGACAGGCATCAACAAACCTATTCACCCCACCATCATCCTGATCTAACCATTCCCCAGTCATCCCAGGAAAACCACTCACAGCCTG ACACTGGGCTGACTTTCTTGAAGATCCTCATCCAATTGGTGTTTTTCAGAAGTGTTCCAATATTATGAATTCTGTGTTGTGGAGAAAAGCAACCATGCAT TTACTGGTCAATGCCTTCTTGTATATGTAATTCAATACTTTTACTTTTAATATCCTCACCTTATCTAATCTTTGAATTTTGTCATGTAATTTATTGCTTC ATTAAGGTTACTTTTTGTTATACAAAATAAAAGCTGATATCCAAGGCATGGTGCATCTTGATGATTTTTTGTCCTTTGAAGTATGGATGATAGAAAAATG TATCAGGTTTATTCATCTCATCTTTCTGTTACAGGATGATTAATTGTACAGTTACATCACACGAAACATTTATAATAAAGTCATGCTTTAGAA

refseq_DISC1.F2 (forward primer)
refseq_DISC1.R2 (reverse primer)
Alternative donor

Frame 0

GRSRRQPRRSGRSWQRGACQAGVLRAPQPPPAA AA*ATAQAAGIAYHLQRAFGGGGWHGGRAT*EAR QGLGSGSFPQQWAHCSGSQEGCLARSPTTRSPG PDSVALTREASWSGALFPRVQQPLL*PL*EEPR RTLGFSSEVAPDCLTGLAGRVALGVLGGSKSLQP WIVLRPWTPAGRQPAAMEQGVSGQQALCHQQS* VATAAALAVALRSPQPLLALTVPLPQALALFGS RLALPGNVEKQKAAHHPERLSPIARAPRRWEPKL PAWTGLTRTRDVSLGPSVSWLHGSLQTWPRPQG TAPGQSVTCILYQTWTLAPPVLWIPHWLAVVVM GAAAQGMPTLGTPCSGNGSQCCGTAC*ETGGRWR *YP*D*NFRNFRKMQLRMMIMIKLRRYNKD*KT WNKRKSACTFNFLQGSQLLAVSWVTWQHKSRLP CAVGPLSRPAEMTPTPH*EWSRGCWNPLLRTACT CPSRDETGFFRKSSSYRKKSKLSKQGCLCWKPK INS*EGK*RSKSSNSSGRAAT*PHWWASCPWVS CRRSARPCRTPWPQPVRFPSMQSHRKP*GASRKE *NPSTCHLKKSLLRCV*VRNSAAP*GRKLTILK PNYQPCLKPKCMPYQETISGRLKTSPRRLDH*H QREKGWRDSSASCWC*VPGMSKSWEVLKKITTD* EEKWSTRRLPMKQV*RKIL*STWKHLRINCAAA SVHCLGKCGKLTWKLVDCLSRAYSSRKPGEACL *KMRGRWMT*RELLLLFPPGSTPRIKGRPL*RNL TSFLQNLEKSVKT*ARSYCTWKINFTQQSTVMM KISFSLSGGSSRW*RKLCRP*SCSSSQQRRREK EKLQLPA*QLVSTKHKPEE*RDGGGRWATMFGPG GLLFPPPP*LRCLNQLRRYRALRSFSGKVVHVH SHQCETEESAIWNMERETDLLNFLLNVTQKFLF HVILGNVFHRI*E*FHLSPH*REVGVNSGKMSLF PVPFAFCCNENIS*FKIL*KGNQA*DSVIIPVT RSYRCTI*ES*LTSESGVNSFSPYFSCDLILS* KN*YAISKRYFGKTTTSQ*YATFQFSFCGNDCI* RKDP*ESLFHQDILKFTHSEAVDGSGDLYKMFE PVPFSRGTCFTQCQAVQHLGKQCSTQ*GSAVLS NTIQYSGSAVLSKTVQCSVRQCNTQ*QCSTQ*Q* STQ*YSTVFSKAVKYSVIQYSTQLGSAVLRNAA QYSGSAILSAVLSNTVQYSVTVQYSVTVQYSVR QCSTQ*HSAVLSNTVQYSVRQYGTQ*SNAMLSNT VQCSIRQCSAQ*GSELLSNTV*CSVGQHSTQ*H RAASTQYYKY*VLI*AM*YSVNQCSTQ*CKGIS GSCWAASLAQLGLLLRQLQNRLISIRQHFPKCTE EGGPKRSSLNKGVPSLVKYLW*IHHTIISAWRT TMHISILV*ERTYSKETHLILSNLKLSKFNGS* IFFM*LLFISHRSSIVQHCIL*GSPSPNSDLHHF RNHTHTFAEC*A**LPATDW*I*SSGCSVCASV LIYVFRDSEVPAFTRIHGYETIFVIS*SHTGVS RRHLVLCSAFHAVQHFCPQSRRWPCLSQQLAGVQ ETKQKHNM*MC*LCSLWLYLEQNTLYIF***V* LACSWTSFSMMNQIPELFIIVSKENYELVTWHL ESLS*FQ*SKTWEESGLATLPITNSYFDICLFKK PPRHKTS*PSLAQVFCITQTPS*NNSVRS*CI* KFCKLITALNCLNPK*GFFGTSSR*CVHFPAAN FEVFGQVSHVLTTSHNSSVVFAWS*SIIQKVR*G PACFFWLHNLLRTSPLS*ATLTLGDTGLCILNH TIQQFLSGEHKNIQERLGLRFKSIKTTTMEIYV GDSQDHKQKHILEMMS*NLI*LGCFMRM*V*YYT VCLAGMLAFKWSPIFLSLA*VRTCYQ**SQFHP TF*NFIFFFEMESLSVTQVGVQWPRNLGSLQPL PPRFKLFYCLSLPSSWGYRHLPPGPDDFCIFSRD RASPCWLGGSQTPDLRRSTPTSASQSAEITGVS HRTRPTF*NFKTELILLQISIYYWKLVFPCSKA GFPTPETCNGWYHAKPLPC*ALYSHIL*SPYQPY KEGVCR*CN*ALRGLIPFF*GTELVKCEVIVNL TVRDRQHALN*CSS*SSFNVLLRF*AMELTCSP G*ELMATVEILVRESKKLSLGQTRLPTLPGEPHC EV*AQTGINKPIHPTIILI*PFPSHPRKTTHSL TLG*LS*RSSSNWCFSEVFQYYEFCVVEKSNHA FTGQCLLVYVIQYFYF*YPHLI*SLNFVM*FIAS LRLLFVIQNKS*YPRHGAS**FFVL*SMDDRKM YQVYSSHLSVTG*LIVQLHHTKHL**SHALE

Frame 1

EGAGGSPGGAGGAGSGAHARRGSSGRPSRRRRR RREPPRRQPGLLTTCSVLSEAAAGTEAGLHEKL DRAWDRVPFPSSGHTVPVPRRGVWRGVPPLGVQG QTVWP*LERPLGPEPCFQECSSPYCDLCERNLG ALWDSAQRWHQIA*QA*LAVWPWECWVAARVCS HG*F*DPGRQLGGSLQRWSKACPGSRLSAISRVE *QQLQPWLWP*GPPNPSWLSQCLYLKL*LYSAL AWLCRGTWRSRRLPTIQRG*VPLPEPPGDGSQS CQLGRASRGPAMSLSALQSLGYTGLCRLGPGRKE QLQARA*HAFFTRHGPWLLQFSGSLTGWLWW*W EQRLRGCPLLGHPAQEMGASAAGLPAEKPEADG GNILKIKTSETSGRCS*E**L**S*DVTTKIRRP GTRENQPALSTSFKAASS*QFPGSPGSTSPGCL APWGHSAGQRR*HPHPTENGAEAVGTHCSGQLA RVHHETRLASSGKAAATERNRSSPSKDVCAGSQR STAEKGNRGARAATPVAGLRPDPTGGPAVPGSA AGGQQGLAGHPGLSRSDSLPCRATGNHKEPPGK NKIPQLVT*RNHY*GVYE*EILQHPEEES*RY*N PTTSLA*SQNACHIRKPFLDG*RPHRGD*IINI RERRAGGTPQQAVGVEFQECQKAGKC*RRLQQT EKRSGAPGDCL*NKCEGKYYEVHGNT*E*TVQLQ VSTAWESVGS*LGSLSIAYPEPTAPGSQGKPVC RR*EADG*LRGSCSSYSPQAPLRG*KEDPFEGI LHPFCRTWRKV*RHRQEAIVLGRSTSHSNPQS** RSHSVSQEGAPDGEGNSAGHDPAAPASKGGGRK RSCSFLHDSWCPRSTSLRSDGMGEGGGPPCLDP GGCSSLPRHS*DA*INYGDTEP*GLSVERWFMFI LISVKLRSLQFGIWRERLIC*ISF*MSLKNFFS MSFLGMSSTGFENSFISAPIREKLG*ILEKCLF FLCHLPSAATKIFPDSRFYKKETKHKTLSSYLLH VPTGAQSKRAN*PQSLELTAFHLTSPVI*YYLR KINMQFPKDILVRQQPPSDMPPFNFPFVAMIAS EERIPESLCFIRTF*NLPTVRLWMDQGTCIKCLS LFHFPVEPVSLNARQCSI*ESSAVLSKAVQYSV TQYSTQAVQYSVRQCSAQ*GSAILSNSVVLSNS EVLSNTVQYSVRQ*STQ*YNTVLS*AVQYSGMQH STQAVQYSVRYSVTQCSTQ*QCSTQ*QCSTQ*G SAVLSNTVQYSVIQYSTQ*GSMVLSKAMQCSVT QCSAQ*GSAVLSKAVNCLVTQCSAQ*DSIVLSNT GQLVLSTISTEYLYRQCSTQ*ISAVLSNARAFQ APAGLLLWPSWDSY*DSCKTG*FQLGSTSQSAL RKVAPREAL*TKEYPLWSSTFGKYTIP*YLLGEP QCTLAY*SERELIVRKLT*FYLTSNFPSLMDRE FFSCNSYSYPIDLVLYSTAFSEEVPVQTLIYIT LETTLTLLQSVELNNYLPQIGKFNPVVVLFVLLF SFMCLGIVRFLPSLGSTDMRPFLSFPEVTLAFP EGIWCFAQPSMLCSTSVLSQGDGHA*ASNWLGS RKQSKSTICECADCVPYGFISSKIHSTYFNNKYN *LVPGLHFQ**TKFLNYL*LCLKKIMNWSHGTW NP*VNSSEAKLGKSQDWPHCQ*QIPTSTYVFSK SLPDTRHLNRH*PKCFVLLRHHHEIIL*GHDVFE NSAS**LP*IV*TRNKGSLVPLVDSVFISLLQI LKYLGR*VMF*PQAITHLLSLLGLRVSFRKSAK GQRASSGYTTFSGQAHCLKPL*PWETQDCVSSII LYSSFCQGNIKISKRG*GLDLKASKQQQWKFML AIAKTTSKSTYWK**VRI*FDWDVL*ECKCDII LSALLECWLSNGHPFFFHWPELGHAISNSPSSIQ LSEISFFFLRWSLSLSPKLECSGPAISAHCNLY LPGSSYSTASASQVAGVTGICHRALMIFVFLVE TGLHHVG*EGLKLLTSGDPPPPRLPKVLRLQV*A TAPGQLSEISKLN*SFSKLVYTIGNLSFPAVRL VSPPQKHVTVGTMLSPCHAKPFTVISYNPHINL IRKVFVDDATEP*ED*FPFSKAQSW*NVK***T* QSETGSMLLTSALPKVPLMSF*DFEPWNLLVHL AKNSWPLWKSWLGSQRN*AWGKRGFPHCQGSLT VKSRLRQASTNLFTPPSS*SNHSPVIPGKPLTA* HWADFLEDPHPIGVFQKCSNIMNSVLWRKATMH LLVNAFLYM*FNTFTFNILTLSNL*ILSCNLLL H*GYFLLYKIKADIQGMVHLDDFLSFEVWMIEKC IRFIHLIFLLQDD*LYSYITRNIYNKVML*

Frame 2

KEQEAAQAEREELAAGRMPGGGPQGAPAAAGGG GVSHRAGSRDCLPPAACFRRRRLARRPGYMRSS TGPGIGFLSPAVGTLFRFPGGVSGEESHHSESR ARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSA HFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAA MDSSETLDASWEAACSDGARRVRAAGSLPSAEL SSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLS LGSAGERGEAEGCPPSREAESHCQSPQEMGAKA ASLDGPHEDPRCLSRPFSLLATRVSADLAQAAR NSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDG SSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQME VISLRLKLQKLQEDAVENDDYDKAETLQQRLED LEQEKISLHFQLPSRQPALSSFLGHLAAQVQAAL RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLH VSITRRDWLLQEKQQLQKEIEALQARMFVLEAK DQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQL QEVSKALQDTLASAGQIPFHAEPPETIRSLQER IKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIE TQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTS EREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRL RREVEHQETAYETSVKENTMKYMETLKNKLCSC KCPLLGKVWEADLEACRLLIQSLQLQEARGSLSV EDERQMDDLEGAAPPIPPRLHSEDKRKTPLKES YILSAELGEKCEDIGKKLLYLEDQLHTAIHSHD EDLIQSLRRELQMVKETLQAMILQLQPAKEAGER EAAASCMTAGVHEAQA*GVTGWGREVGHHVWTR GAALPSPAIAKMPESITEIQSLEVFQWKGGSCS FSSV*N*GVCNLEYGERD*FAEFPSKCHSKISFP CHSWECLPQDLRIVSSQPPLERSWGEFWKNVSF SCAICLLLQRKYFLIQDSIKRKPSIRLCHHTCY TFLQVHNLRELINLRVWS*QLFTLLLL*SNIILE KLICNFQKIFW*DNNLPVICHLSIFLLWQ*LHL KKGSLRVSVSSGHSEIYPQ*GCGWIRGPV*NV* ACSIFPWNLFHSMPGSAAFRKAVQYSVRQCSTQ* HNTVLRQCSTQ*DSAVLSKAVQYSVTV*YSVTV KYSVIQYSIQ*GSEVLSNTIQYSVRQCSTQECS TVLRQCNTQCGTQ*HSAVLSNSAVLSNSAVLSKA VQYSVTQCSTQ*YSTVLSKAVWYSVKQCNAQ*H SAVLNKAVQCSVRQ*IA**HSVVLSRTA*YSVT QGS*YSVL*VLSTYIGNVVLSKSVQYSVMQGHFR LLLGCFFGPAGTPIETAAKQADFN*AALPKVH* GRWPQEKLSKQRSTLSGQVPLVNTPYHNICLEN HNAH*HISLRENL**GNSLDFI*PQTFQV*WIVN FFHVTPIHIP*I*YCTALHSLRKSQSKL*FTSL *KPHSHFCRVLSLITTCHRLVNLIQWLFCLCFC SHLCV*G**GSCLH*DPRI*DHFCHFLKSHWRFQ KASGALLSLPCCAALLSSVKEMAMLKPAIGWGP GNKAKAQYVNVLIVFPMALSRAKYTLHILIISI ISLFLDFIFNDEPNS*IIYNCV*RKL*TGHMALG ILELIPVKQNLGRVRIGHIANNKFLLRHMSFQK ASQTQDILTVTSPSVLYYSDTIMK*FCEVMMYL KILQVNNCLELFEPEIRVLWYL**IVCSFPCCKF *SIWAGESCFNHKP*LICCLCLVLEYHSESPLR ASVLLLATQPSQDKPTVLSHFDPGRHRTVYPQS YYTAVFVRGT*KYPREVRA*I*KHQNNNNGNLCW R*PRPQAKAHTGNDELESDLTGMFYENVSVILY CLPCWNAGFQMVTHFSFTGLS*DMLSVIVPVPS NFLKFHFFF*DGVSLCHPSWSAVAPQSRLTATST SQVQAILLPQPPK*LGLQAFATGP**FLYF**R QGFTMLARRVSNS*PQAIHPHLGFPKC*DYRCE PPHPANFLKFQN*IDPSPN*YILLETCLSLQ*GW FPHPRNM*RLVPC*ALAMLSPLQSYPIIPISTL *GRCL*MMQLSLKRTNSLFLRHRAGKM*SNSEP NSQRQAACS*LVLFLKFL*CPFEILSHGTYLFTW LRTHGHCGNLG*GVKETEPGANEASHTARGASL *SLGSDRHQQTYSPHHHPDLTIPQSSQENHSQP DTGLTFLKILIQLVFFRSVPIL*ILCCGEKQPCI YWSMPSCICNSILLLLISSPYLIFEFCHVIYCF IKVTFCYTK*KLISKAWCILMIFCPLKYG**KN VSGLFISSFCYRMINCTVTSHETFIIKSCFR

Sequence NM_018662

GGAAGGAGCAGGAGGCAGCCCAGGCGGAGCGGGAGGAGCTGGCAGCGGGGCGCATGCCAGGCGGGGGTCCTCAGGGCGCCCCAGCCGCCGCCGGCGGCGG CGGCGTGAGCCACCGCGCAGGCAGCCGGGATTGCTTACCACCTGCAGCGTGCTTTCGGAGGCGGCGGCTGGCACGGAGGCCGGGCTACATGAGAAGCTCG ACAGGGCCTGGGATCGGGTTCCTTTCCCCAGCAGTGGGCACACTGTTCCGGTTCCCAGGAGGGGTGTCTGGCGAGGAGTCCCACCACTCGGAGTCCAGGG CCAGACAGTGTGGCCTTGACTCGAGAGGCCTCTTGGTCCGGAGCCCTGTTTCCAAGAGTGCAGCAGCCCCTACTGTGACCTCTGTGAGAGGAACCTCGGC GCACTTTGGGATTCAGCTCAGAGGTGGCACCAGATTGCCTGACAGGCTTAGCTGGCCGTGTGGCCCTGGGAGTGCTGGGTGGCAGCAAGAGTTTGCAGCC ATGGATAGTTCTGAGACCCTGGACGCCAGCTGGGAGGCAGCCTGCAGCGATGGAGCAAGGCGTGTCCGGGCAGCAGGCTCTCTGCCATCAGCAGAGTTGA GTAGCAACAGCTGCAGCCCTGGCTGTGGCCCTGAGGTCCCCCCAACCCCTCCTGGCTCTCACAGTGCCTTTACCTCAAGCTTTAGCTTTATTCGGCTCTC GCTTGGCTCTGCCGGGGAACGTGGAGAAGCAGAAGGCTGCCCACCATCCAGAGAGGCTGAGTCCCATTGCCAGAGCCCCCAGGAGATGGGAGCCAAAGCT GCCAGCTTGGACGGGCCTCACGAGGACCCGCGATGTCTCTCTCGGCCCTTCAGTCTCTTGGCTACACGGGTCTCTGCAGACTTGGCCCAGGCCGCAAGGA ACAGCTCCAGGCCAGAGCGTGACATGCATTCTTTACCAGACATGGACCCTGGCTCCTCCAGTTCTCTGGATCCCTCACTGGCTGGCTGTGGTGGTGATGG GAGCAGCGGCTCAGGGGATGCCCACTCTTGGGACACCCTGCTCAGGAAATGGGAGCCAGTGCTGCGGGACTGCCTGCTGAGAAACCGGAGGCAGATGGAG GTAATATCCTTAAGATTAAAACTTCAGAAACTTCAGGAAGATGCAGTTGAGAATGATGATTATGATAAAGCTGAGACGTTACAACAAAGATTAGAAGACC TGGAACAAGAGAAAATCAGCCTGCACTTTCAACTTCCTTCAAGGCAGCCAGCTCTTAGCAGTTTCCTGGGTCACCTGGCAGCACAAGTCCAGGCTGCCTT GCGCCGTGGGGCCACTCAGCAGGCCAGCGGAGATGACACCCACACCCCACTGAGAATGGAGCCGAGGCTGTTGGAACCCACTGCTCAGGACAGCTTGCAC GTGTCCATCACGAGACGAGACTGGCTTCTTCAGGAAAAGCAGCAGCTACAGAAAGAAATCGAAGCTCTCCAAGCAAGGATGTTTGTGCTGGAAGCCAAAG ATCAACAGCTGAGAAGGGAAATAGAGGAGCAAGAGCAGCAACTCCAGTGGCAGGGCTGCGACCTGACCCCACTGGTGGGCCAGCTGTCCCTGGGTCAGCT GCAGGAGGTCAGCAAGGCCTTGCAGGACACCCTGGCCTCAGCCGGTCAGATTCCCTTCCATGCAGAGCCACCGGAAACCATAAGGAGCCTCCAGGAAAGA ATAAAATCCCTCAACTTGTCACTTAAAGAAATCACTACTAAGGTGTGTATGAGTGAGAAATTCTGCAGCACCCTGAGGAAGAAAGTTAACGATATTGAAA CCCAACTACCAGCCTTGCTTGAAGCCAAAATGCATGCCATATCAGGAAACCATTTCTGGACGGCTAAAGACCTCACCGAGGAGATTAGATCATTAACATC AGAGAGAGAAGGGCTGGAGGGACTCCTCAGCAAGCTGTTGGTGTTGAGTTCCAGGAATGTCAAAAAGCTGGGAAGTGTTAAAGAAGATTACAACAGACTG AGAAGAGAAGTGGAGCACCAGGAGACTGCCTATGAAACAAGTGTGAAGGAAAATACTATGAAGTACATGGAAACACTTAAGAATAAACTGTGCAGCTGCA AGTGTCCACTGCTTGGGAAAGTGTGGGAAGCTGACTTGGAAGCTTGTCGATTGCTTATCCAGAGCCTACAGCTCCAGGAAGCCAGGGGAAGCCTGTCTGT AGAAGATGAGAGGCAGATGGATGACTTAGAGGGAGCTGCTCCTCCTATTCCCCCCAGGCTCCACTCCGAGGATAAAAGGAAGACCCCTTTGAAGGTATTG GAAGAATGGAAGACTCACCTCATCCCCTCTCTGCACTGTGCTGGAGGTGAACAGAAAGAGGAATCTTACATCCTTTCTGCAGAACTTGGAGAAAAGTGTG AAGACATAGGCAAGAAGCTATTGTACTTGGAAGATCAACTTCACACAGCAATCCACAGTCATGATGAAGATCTCATTCAGTCTCTCAGGAGGGAGCTCCA GATGGTGAAGGAAACTCTGCAGGCCATGATCCTGCAGCTCCAGCCAGCAAAGGAGGCGGGAGAAAGAGAAGCTGCAGCTTCCTGCATGACAGCTGGTGTC CACGAAGCACAAGCCTGAGGAGTGACGGGATGGGGGAGGGAGGTGGGCCACCATGTTTGGACCCGGGGGGCTGCTCTTCCCTCCCCCGCCATAGCTAAGA TGCCTGAATCAATTACGGAGATACAGAGCCTTGAGGTCTTTCAGTGGAAAGGTGGTTCATGTTCATTCTCATCAGTGTGAAACTGAGGAGTCTGCAATTT GGAATATGGAGAGAGAGACTGATTTGCTGAATTTCCTTCTAAATGTCACTCAAAAATTTCTTTTCCATGTCATTCTTGGGAATGTCTTCCACAGGATTTG AGAATAGTTTCATCTCAGCCCCCATTAGAGAGAAGTTGGGGTGAATTCTGGAAAAATGTCTCTTTTTCCTGTGCCATTTGCCTTCTGCTGCAACGAAAAT ATTTCCTGATTCAAGATTCTATAAAAAGGAAACCAAGCATAAGACTCTGTCATCATACCTGTTACACGTTCCTACAGGTGCACAATCTAAGAGAGCTAAT TAACCTCAGAGTCTGGAGTTAACAGCTTTTCACCTTACTTCTCCTGTGATCTAATATTATCTTAGAAAAATTAATATGCAATTTCCAAAAGATATTTTGG TAAGACAACAACCTCCCAGTGATATGCCACCTTTCAATTTTCCTTTTGTGGCAATGATTGCATCTGAAGAAAGGATCCCTGAGAGTCTCTGTTTCATCAG GACATTCTGAAATTTACCCACAGTGAGGCTGTGGATGGATCAGGGGACCTGTATAAAATGTTTGAGCCTGTTCCATTTTCCCGTGGAACCTGTTTCACTC AATGCCAGGCAGTGCAGCATTTAGGAAAGCAGTGCAGTACTCAGTAAGGCAGTGCAGTACTCAGTAACACAATACAGTACTCAGGCAGTGCAGTACTCAG TAAGACAGTGCAGTGCTCAGTAAGGCAGTGCAATACTCAGTAACAGTGTAGTACTCAGTAACAGTGAAGTACTCAGTAATACAGTACAGTATTCAGTAAG GCAGTGAAGTACTCAGTAATACAATACAGTACTCAGTTAGGCAGTGCAGTACTCAGGAATGCAGCACAGTACTCAGGCAGTGCAATACTCAGTGCGGTAC TCAGTAACACAGTGCAGTACTCAGTAACAGTGCAGTACTCAGTAACAGTGCAGTACTCAGTAAGGCAGTGCAGTACTCAGTAACACAGTGCAGTACTCAG TAATACAGTACAGTACTCAGTAAGGCAGTATGGTACTCAGTAAAGCAATGCAATGCTCAGTAACACAGTGCAGTGCTCAATAAGGCAGTGCAGTGCTCAG TAAGGCAGTGAATTGCTTAGTAACACAGTGTAGTGCTCAGTAGGACAGCATAGTACTCAGTAACACAGGGCAGCTAGTACTCAGTACTATAAGTACTGAG TACTTATATAGGCAATGTAGTACTCAGTAAATCAGTGCAGTACTCAGTAATGCAAGGGCATTTCAGGCTCCTGCTGGGCTGCTTCTTTGGCCCAGCTGGG ACTCCTATTGAGACAGCTGCAAAACAGGCTGATTTCAATTAGGCAGCACTTCCCAAAGTGCACTGAGGAAGGTGGCCCCAAGAGAAGCTCTCTAAACAAA GGAGTACCCTCTCTGGTCAAGTACCTTTGGTAAATACACCATACCATAATATCTGCTTGGAGAACCACAATGCACATTAGCATATTAGTCTGAGAGAGAA CTTATAGTAAGGAAACTCACTTGATTTTATCTAACCTCAAACTTTCCAAGTTTAATGGATCGTGAATTTTTTTCATGTAACTCCTATTCATATCCCATAG ATCTAGTATTGTACAGCACTGCATTCTCTGAGGAAGTCCCAGTCCAAACTCTGATTTACATCACTTTAGAAACCACACTCACACTTTTGCAGAGTGTTGA GCTTAATAACTACCTGCCACAGATTGGTAAATTTAATCCAGTGGTTGTTCTGTTTGTGCTTCTGTTCTCATTTATGTGTTTAGGGATAGTGAGGTTCCTG CCTTCACTAGGATCCACGGATATGAGACCATTTTTGTCATTTCCTGAAGTCACACTGGCGTTTCCAGAAGGCATCTGGTGCTTTGCTCAGCCTTCCATGC TGTGCAGCACTTCTGTCCTCAGTCAAGGAGATGGCCATGCTTAAGCCAGCAATTGGCTGGGGTCCAGGAAACAAAGCAAAAGCACAATATGTGAATGTGC TGATTGTGTTCCCTATGGCTTTATCTCGAGCAAAATACACTCTACATATTTTAATAATAAGTATAATTAGCTTGTTCCTGGACTTCATTTTCAATGATGA ACCAAATTCCTGAATTATTTATAATTGTGTCTAAAGAAAATTATGAACTGGTCACATGGCACTTGGAATCCTTGAGTTAATTCCAGTGAAGCAAAACTTG GGAAGAGTCAGGATTGGCCACATTGCCAATAACAAATTCCTACTTCGACATATGTCTTTTCAAAAAGCCTCCCAGACACAAGACATCTTAACCGTCACTA GCCCAAGTGTTTTGTATTACTCAGACACCATCATGAAATAATTCTGTGAGGTCATGATGTATTTGAAAATTCTGCAAGTTAATAACTGCCTTGAATTGTT TGAACCCGAAATAAGGGTTCTTTGGTACCTCTAGTAGATAGTGTGTTCATTTCCCTGCTGCAAATTTTGAAGTATTTGGGCAGGTGAGTCATGTTTTAAC CACAAGCCATAACTCATCTGTTGTCTTTGCTTGGTCTTAGAGTATCATTCAGAAAGTCCGCTAAGGGCCAGCGTGCTTCTTCTGGCTACACAACCTTCTC AGGACAAGCCCACTGTCTTAAGCCACTTTGACCCTGGGAGACACAGGACTGTGTATCCTCAATCATACTATACAGCAGTTTTTGTCAGGGGAACATAAAA ATATCCAAGAGAGGTTAGGGCTTAGATTTAAAAGCATCAAAACAACAACAATGGAAATTTATGTTGGCGATAGCCAAGACCACAAGCAAAAGCACATACT GGAAATGATGAGTTAGAATCTGATTTGACTGGGATGTTTTATGAGAATGTAAGTGTGATATTATACTGTCTGCCTTGCTGGAATGCTGGCTTTCAAATGG TCACCCATTTTTCTTTCACTGGCCTGAGTTAGGACATGCTATCAGTAATAGTCCCAGTTCCATCCAACTTTCTGAAATTTCATTTTTTTTTTTGAGATGG AGTCTCTCTCTGTCACCCAAGTTGGAGTGCAGTGGCCCCGCAATCTCGGCTCACTGCAACCTCTACCTCCCAGGTTCAAGCTATTCTACTGCCTCAGCCT CCCAAGTAGCTGGGGTTACAGGCATTTGCCACCGGGCCCTGATGATTTTTGTATTTTTAGTAGAGACAGGGCTTCACCATGTTGGCTAGGAGGGTCTCAA ACTCCTGACCTCAGGCGATCCACCCCCACCTCGGCTTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACCGCACCCGGCCAACTTTCTGAAATTTCAAAA CTGAATTGATCCTTCTCCAAATTAGTATATACTATTGGAAACTTGTCTTTCCCTGCAGTAAGGCTGGTTTCCCCACCCCAGAAACATGTAACGGTTGGTA CCATGCTAAGCCCTTGCCATGCTAAGCCCTTTACAGTCATATCCTATAATCCCCATATCAACCTTATAAGGAAGGTGTTTGTAGATGATGCAACTGAGCC TTAAGAGGACTAATTCCCTTTTTCTAAGGCACAGAGCTGGTAAAATGTGAAGTAATAGTGAACCTAACAGTCAGAGACAGGCAGCATGCTCTTAACTAGT GCTCTTCCTAAAGTTCCTTTAATGTCCTTTTGAGATTTTGAGCCATGGAACTTACTTGTTCACCTGGCTAAGAACTCATGGCCACTGTGGAAATCTTGGT TAGGGAGTCAAAGAAACTGAGCCTGGGGCAAACGAGGCTTCCCACACTGCCAGGGGAGCCTCACTGTGAAGTCTAGGCTCAGACAGGCATCAACAAACCT ATTCACCCCACCATCATCCTGATCTAACCATTCCCCAGTCATCCCAGGAAAACCACTCACAGCCTGACACTGGGCTGACTTTCTTGAAGATCCTCATCCA ATTGGTGTTTTTCAGAAGTGTTCCAATATTATGAATTCTGTGTTGTGGAGAAAAGCAACCATGCATTTACTGGTCAATGCCTTCTTGTATATGTAATTCA ATACTTTTACTTTTAATATCCTCACCTTATCTAATCTTTGAATTTTGTCATGTAATTTATTGCTTCATTAAGGTTACTTTTTGTTATACAAAATAAAAGC TGATATCCAAGGCATGGTGCATCTTGATGATTTTTTGTCCTTTGAAGTATGGATGATAGAAAAATGTATCAGGTTTATTCATCTCATCTTTCTGTTACAG GATGATTAATTGTACAGTTACATCACACGAAACATTTATAATAAAGTCATGCTTTAGAA

refseq_DISC1.F2 (forward primer)
refseq_DISC1.R2 (reverse primer)
Alternative donor

Frame 0

GRSRRQPRRSGRSWQRGACQAGVLRAPQPPPAA AA*ATAQAAGIAYHLQRAFGGGGWHGGRAT*EAR QGLGSGSFPQQWAHCSGSQEGCLARSPTTRSPG PDSVALTREASWSGALFPRVQQPLL*PL*EEPR RTLGFSSEVAPDCLTGLAGRVALGVLGGSKSLQP WIVLRPWTPAGRQPAAMEQGVSGQQALCHQQS* VATAAALAVALRSPQPLLALTVPLPQALALFGS RLALPGNVEKQKAAHHPERLSPIARAPRRWEPKL PAWTGLTRTRDVSLGPSVSWLHGSLQTWPRPQG TAPGQSVTCILYQTWTLAPPVLWIPHWLAVVVM GAAAQGMPTLGTPCSGNGSQCCGTAC*ETGGRWR *YP*D*NFRNFRKMQLRMMIMIKLRRYNKD*KT WNKRKSACTFNFLQGSQLLAVSWVTWQHKSRLP CAVGPLSRPAEMTPTPH*EWSRGCWNPLLRTACT CPSRDETGFFRKSSSYRKKSKLSKQGCLCWKPK INS*EGK*RSKSSNSSGRAAT*PHWWASCPWVS CRRSARPCRTPWPQPVRFPSMQSHRKP*GASRKE *NPSTCHLKKSLLRCV*VRNSAAP*GRKLTILK PNYQPCLKPKCMPYQETISGRLKTSPRRLDH*H QREKGWRDSSASCWC*VPGMSKSWEVLKKITTD* EEKWSTRRLPMKQV*RKIL*STWKHLRINCAAA SVHCLGKCGKLTWKLVDCLSRAYSSRKPGEACL *KMRGRWMT*RELLLLFPPGSTPRIKGRPL*RYW KNGRLTSSPLCTVLEVNRKRNLTSFLQNLEKSV KT*ARSYCTWKINFTQQSTVMMKISFSLSGGSS RW*RKLCRP*SCSSSQQRRREKEKLQLPA*QLVS TKHKPEE*RDGGGRWATMFGPGGLLFPPPP*LR CLNQLRRYRALRSFSGKVVHVHSHQCETEESAI WNMERETDLLNFLLNVTQKFLFHVILGNVFHRI* E*FHLSPH*REVGVNSGKMSLFPVPFAFCCNEN IS*FKIL*KGNQA*DSVIIPVTRSYRCTI*ES* LTSESGVNSFSPYFSCDLILS*KN*YAISKRYFG KTTTSQ*YATFQFSFCGNDCI*RKDP*ESLFHQ DILKFTHSEAVDGSGDLYKMFEPVPFSRGTCFT QCQAVQHLGKQCSTQ*GSAVLSNTIQYSGSAVLS KTVQCSVRQCNTQ*QCSTQ*Q*STQ*YSTVFSK AVKYSVIQYSTQLGSAVLRNAAQYSGSAILSAV LSNTVQYSVTVQYSVTVQYSVRQCSTQ*HSAVLS NTVQYSVRQYGTQ*SNAMLSNTVQCSIRQCSAQ *GSELLSNTV*CSVGQHSTQ*HRAASTQYYKY* VLI*AM*YSVNQCSTQ*CKGISGSCWAASLAQLG LLLRQLQNRLISIRQHFPKCTEEGGPKRSSLNK GVPSLVKYLW*IHHTIISAWRTTMHISILV*ER TYSKETHLILSNLKLSKFNGS*IFFM*LLFISHR SSIVQHCIL*GSPSPNSDLHHFRNHTHTFAEC* A**LPATDW*I*SSGCSVCASVLIYVFRDSEVP AFTRIHGYETIFVIS*SHTGVSRRHLVLCSAFHA VQHFCPQSRRWPCLSQQLAGVQETKQKHNM*MC *LCSLWLYLEQNTLYIF***V*LACSWTSFSMM NQIPELFIIVSKENYELVTWHLESLS*FQ*SKTW EESGLATLPITNSYFDICLFKKPPRHKTS*PSL AQVFCITQTPS*NNSVRS*CI*KFCKLITALNC LNPK*GFFGTSSR*CVHFPAANFEVFGQVSHVLT TSHNSSVVFAWS*SIIQKVR*GPACFFWLHNLL RTSPLS*ATLTLGDTGLCILNHTIQQFLSGEHK NIQERLGLRFKSIKTTTMEIYVGDSQDHKQKHIL EMMS*NLI*LGCFMRM*V*YYTVCLAGMLAFKW SPIFLSLA*VRTCYQ**SQFHPTF*NFIFFFEM ESLSVTQVGVQWPRNLGSLQPLPPRFKLFYCLSL PSSWGYRHLPPGPDDFCIFSRDRASPCWLGGSQ TPDLRRSTPTSASQSAEITGVSHRTRPTF*NFK TELILLQISIYYWKLVFPCSKAGFPTPETCNGWY HAKPLPC*ALYSHIL*SPYQPYKEGVCR*CN*A LRGLIPFF*GTELVKCEVIVNLTVRDRQHALN* CSS*SSFNVLLRF*AMELTCSPG*ELMATVEILV RESKKLSLGQTRLPTLPGEPHCEV*AQTGINKP IHPTIILI*PFPSHPRKTTHSLTLG*LS*RSSS NWCFSEVFQYYEFCVVEKSNHAFTGQCLLVYVIQ YFYF*YPHLI*SLNFVM*FIASLRLLFVIQNKS *YPRHGAS**FFVL*SMDDRKMYQVYSSHLSVT G*LIVQLHHTKHL**SHALE

Frame 1

EGAGGSPGGAGGAGSGAHARRGSSGRPSRRRRR RREPPRRQPGLLTTCSVLSEAAAGTEAGLHEKL DRAWDRVPFPSSGHTVPVPRRGVWRGVPPLGVQG QTVWP*LERPLGPEPCFQECSSPYCDLCERNLG ALWDSAQRWHQIA*QA*LAVWPWECWVAARVCS HG*F*DPGRQLGGSLQRWSKACPGSRLSAISRVE *QQLQPWLWP*GPPNPSWLSQCLYLKL*LYSAL AWLCRGTWRSRRLPTIQRG*VPLPEPPGDGSQS CQLGRASRGPAMSLSALQSLGYTGLCRLGPGRKE QLQARA*HAFFTRHGPWLLQFSGSLTGWLWW*W EQRLRGCPLLGHPAQEMGASAAGLPAEKPEADG GNILKIKTSETSGRCS*E**L**S*DVTTKIRRP GTRENQPALSTSFKAASS*QFPGSPGSTSPGCL APWGHSAGQRR*HPHPTENGAEAVGTHCSGQLA RVHHETRLASSGKAAATERNRSSPSKDVCAGSQR STAEKGNRGARAATPVAGLRPDPTGGPAVPGSA AGGQQGLAGHPGLSRSDSLPCRATGNHKEPPGK NKIPQLVT*RNHY*GVYE*EILQHPEEES*RY*N PTTSLA*SQNACHIRKPFLDG*RPHRGD*IINI RERRAGGTPQQAVGVEFQECQKAGKC*RRLQQT EKRSGAPGDCL*NKCEGKYYEVHGNT*E*TVQLQ VSTAWESVGS*LGSLSIAYPEPTAPGSQGKPVC RR*EADG*LRGSCSSYSPQAPLRG*KEDPFEGI GRMEDSPHPLSALCWR*TERGILHPFCRTWRKV* RHRQEAIVLGRSTSHSNPQS**RSHSVSQEGAP DGEGNSAGHDPAAPASKGGGRKRSCSFLHDSWC PRSTSLRSDGMGEGGGPPCLDPGGCSSLPRHS*D A*INYGDTEP*GLSVERWFMFILISVKLRSLQF GIWRERLIC*ISF*MSLKNFFSMSFLGMSSTGF ENSFISAPIREKLG*ILEKCLFFLCHLPSAATKI FPDSRFYKKETKHKTLSSYLLHVPTGAQSKRAN *PQSLELTAFHLTSPVI*YYLRKINMQFPKDIL VRQQPPSDMPPFNFPFVAMIASEERIPESLCFIR TF*NLPTVRLWMDQGTCIKCLSLFHFPVEPVSL NARQCSI*ESSAVLSKAVQYSVTQYSTQAVQYS VRQCSAQ*GSAILSNSVVLSNSEVLSNTVQYSVR Q*STQ*YNTVLS*AVQYSGMQHSTQAVQYSVRY SVTQCSTQ*QCSTQ*QCSTQ*GSAVLSNTVQYS VIQYSTQ*GSMVLSKAMQCSVTQCSAQ*GSAVLS KAVNCLVTQCSAQ*DSIVLSNTGQLVLSTISTE YLYRQCSTQ*ISAVLSNARAFQAPAGLLLWPSW DSY*DSCKTG*FQLGSTSQSALRKVAPREAL*TK EYPLWSSTFGKYTIP*YLLGEPQCTLAY*SERE LIVRKLT*FYLTSNFPSLMDREFFSCNSYSYPI DLVLYSTAFSEEVPVQTLIYITLETTLTLLQSVE LNNYLPQIGKFNPVVVLFVLLFSFMCLGIVRFL PSLGSTDMRPFLSFPEVTLAFPEGIWCFAQPSM LCSTSVLSQGDGHA*ASNWLGSRKQSKSTICECA DCVPYGFISSKIHSTYFNNKYN*LVPGLHFQ** TKFLNYL*LCLKKIMNWSHGTWNP*VNSSEAKL GKSQDWPHCQ*QIPTSTYVFSKSLPDTRHLNRH* PKCFVLLRHHHEIIL*GHDVFENSAS**LP*IV *TRNKGSLVPLVDSVFISLLQILKYLGR*VMF* PQAITHLLSLLGLRVSFRKSAKGQRASSGYTTFS GQAHCLKPL*PWETQDCVSSIILYSSFCQGNIK ISKRG*GLDLKASKQQQWKFMLAIAKTTSKSTY WK**VRI*FDWDVL*ECKCDIILSALLECWLSNG HPFFFHWPELGHAISNSPSSIQLSEISFFFLRW SLSLSPKLECSGPAISAHCNLYLPGSSYSTASA SQVAGVTGICHRALMIFVFLVETGLHHVG*EGLK LLTSGDPPPPRLPKVLRLQV*ATAPGQLSEISK LN*SFSKLVYTIGNLSFPAVRLVSPPQKHVTVG TMLSPCHAKPFTVISYNPHINLIRKVFVDDATEP *ED*FPFSKAQSW*NVK***T*QSETGSMLLTS ALPKVPLMSF*DFEPWNLLVHLAKNSWPLWKSW LGSQRN*AWGKRGFPHCQGSLTVKSRLRQASTNL FTPPSS*SNHSPVIPGKPLTA*HWADFLEDPHP IGVFQKCSNIMNSVLWRKATMHLLVNAFLYM*F NTFTFNILTLSNL*ILSCNLLLH*GYFLLYKIKA DIQGMVHLDDFLSFEVWMIEKCIRFIHLIFLLQ DD*LYSYITRNIYNKVML*

Frame 2

KEQEAAQAEREELAAGRMPGGGPQGAPAAAGGG GVSHRAGSRDCLPPAACFRRRRLARRPGYMRSS TGPGIGFLSPAVGTLFRFPGGVSGEESHHSESR ARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSA HFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAA MDSSETLDASWEAACSDGARRVRAAGSLPSAEL SSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLS LGSAGERGEAEGCPPSREAESHCQSPQEMGAKA ASLDGPHEDPRCLSRPFSLLATRVSADLAQAAR NSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDG SSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQME VISLRLKLQKLQEDAVENDDYDKAETLQQRLED LEQEKISLHFQLPSRQPALSSFLGHLAAQVQAAL RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLH VSITRRDWLLQEKQQLQKEIEALQARMFVLEAK DQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQL QEVSKALQDTLASAGQIPFHAEPPETIRSLQER IKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIE TQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTS EREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRL RREVEHQETAYETSVKENTMKYMETLKNKLCSC KCPLLGKVWEADLEACRLLIQSLQLQEARGSLSV EDERQMDDLEGAAPPIPPRLHSEDKRKTPLKVL EEWKTHLIPSLHCAGGEQKEESYILSAELGEKC EDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQ MVKETLQAMILQLQPAKEAGEREAAASCMTAGV HEAQA*GVTGWGREVGHHVWTRGAALPSPAIAK MPESITEIQSLEVFQWKGGSCSFSSV*N*GVCNL EYGERD*FAEFPSKCHSKISFPCHSWECLPQDL RIVSSQPPLERSWGEFWKNVSFSCAICLLLQRK YFLIQDSIKRKPSIRLCHHTCYTFLQVHNLRELI NLRVWS*QLFTLLLL*SNIILEKLICNFQKIFW *DNNLPVICHLSIFLLWQ*LHLKKGSLRVSVSS GHSEIYPQ*GCGWIRGPV*NV*ACSIFPWNLFHS MPGSAAFRKAVQYSVRQCSTQ*HNTVLRQCSTQ *DSAVLSKAVQYSVTV*YSVTVKYSVIQYSIQ* GSEVLSNTIQYSVRQCSTQECSTVLRQCNTQCGT Q*HSAVLSNSAVLSNSAVLSKAVQYSVTQCSTQ *YSTVLSKAVWYSVKQCNAQ*HSAVLNKAVQCS VRQ*IA**HSVVLSRTA*YSVTQGS*YSVL*VLS TYIGNVVLSKSVQYSVMQGHFRLLLGCFFGPAG TPIETAAKQADFN*AALPKVH*GRWPQEKLSKQ RSTLSGQVPLVNTPYHNICLENHNAH*HISLREN L**GNSLDFI*PQTFQV*WIVNFFHVTPIHIP* I*YCTALHSLRKSQSKL*FTSL*KPHSHFCRVL SLITTCHRLVNLIQWLFCLCFCSHLCV*G**GSC LH*DPRI*DHFCHFLKSHWRFQKASGALLSLPC CAALLSSVKEMAMLKPAIGWGPGNKAKAQYVNV LIVFPMALSRAKYTLHILIISIISLFLDFIFNDE PNS*IIYNCV*RKL*TGHMALGILELIPVKQNL GRVRIGHIANNKFLLRHMSFQKASQTQDILTVT SPSVLYYSDTIMK*FCEVMMYLKILQVNNCLELF EPEIRVLWYL**IVCSFPCCKF*SIWAGESCFN HKP*LICCLCLVLEYHSESPLRASVLLLATQPS QDKPTVLSHFDPGRHRTVYPQSYYTAVFVRGT*K YPREVRA*I*KHQNNNNGNLCWR*PRPQAKAHT GNDELESDLTGMFYENVSVILYCLPCWNAGFQM VTHFSFTGLS*DMLSVIVPVPSNFLKFHFFF*DG VSLCHPSWSAVAPQSRLTATSTSQVQAILLPQP PK*LGLQAFATGP**FLYF**RQGFTMLARRVS NS*PQAIHPHLGFPKC*DYRCEPPHPANFLKFQN *IDPSPN*YILLETCLSLQ*GWFPHPRNM*RLV PC*ALAMLSPLQSYPIIPISTL*GRCL*MMQLS LKRTNSLFLRHRAGKM*SNSEPNSQRQAACS*LV LFLKFL*CPFEILSHGTYLFTWLRTHGHCGNLG *GVKETEPGANEASHTARGASL*SLGSDRHQQT YSPHHHPDLTIPQSSQENHSQPDTGLTFLKILIQ LVFFRSVPIL*ILCCGEKQPCIYWSMPSCICNS ILLLLISSPYLIFEFCHVIYCFIKVTFCYTK*K LISKAWCILMIFCPLKYG**KNVSGLFISSFCYR MINCTVTSHETFIIKSCFR