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Sequences

Sequence NM_172059

CTCCTTTTTCTCTTTTGGTTAAAAGAGAGCATTGTCGTTCTCAGCCATGTGCTCTGTATAATTAAGAGCTGACACTGAAGCAGAGTAACAACATCTTCTA
ATTTTTTTACCCCTGATCACAGGTGCAAACATCTCAAGCCAGTTCAGATGTTGCTGTTTCCTCAAGTTGCAGGTCTATGGAAATGCAGGATCTAACCAGC
CCGCATAGCCGTCTGAGTGGTAGTAGTGAATCCCCCAGTGGCCCCAAACTCGGTAACTCTCATATAAATAGTAATTCCATGACTCCCAATGGCACCGAAG
TTAAAACAGAGCCAATGAGCAGCAGTGAAACAGCTTCAACGACAGCCGACGGGTCTTTAAACAATTTCTCAGGTTCAGCAATTGGGAGCAGTAGTTTCAG
CCCACGACCAACTCACCAGTTCTCTCCACCACAGATTTACCCTTCCAACAGACCATACCCACATATTCTCCCTACCCCTTCCTCACAAACTATGGCTGCA
TATGGGCAAACACAGTTTACCACAGGAATGCAACAAGCTACAGCCTATGCCACGTACCCACAGCCAGGACAGCCGTACGGCATTTCCTCATATGGCATCA
AGACTGAAGGTGGATTGTCACAGTCTCAGTCACCTGGACAGACAGGATTTCTCAGCTATGGCACAAGCTTCAGTACCCCTCAACCTGGACAGGCACCATA
CAGCTACCAGATGCAAGGTAGCAGTTTTACAACATCATCAGGAATATATACAGGAAATAATTCACTCACAAATTCCTCTGGATTTAATAGTTCACAGCAG
GACTATCCGTCTTATCCCAGTTTTGGCCAGGGTCAGTACGCACAGTATTATAACAGCTCACCGTATCCAGCACATTATATGACCAGCAGCAACACCAGCC
CAACGACACCATCCACCAATGCCACTTACCAGCTTCAAGAACCGCCATCTGGCATCACCAGCCAAGCAGTTACAGATCCCACAGCAGAGTACAGCACAAT
CCACAGCCCATCAACACCCATTAAAGATTCAGATTCTGATCGATTGCGTCGAGGTTCAGATGGGAAATCACGTGGACGGGGCCGAAGAAACAATAATCCT
TCACCTCCCCCAGATTCTGATCTTGAGAGAGTGTTCATCTGGGACTTGGATGAGACAATCATTGTTTTCCACTCCTTGCTTACTGGGTCCTACGCCAACA
GATATGGGAGGGAATGTGACCAAGTCCATATAGATGATGTTTCTTCAGATGATAACGGACAGGACCTAAGCACATATAACTTTGGAACAGATGGCTTTCC
TGCTGCAGCAACCAGTGCTAACTTATGTTTGGCAACTGGTGTACGGGGCGGTGTGGACTGGATGAGAAAGTTGGCCTTCCGCTACAGACGGGTAAAAGAG
ATCTACAACACCTACAAAAATAATGTTGGAGGTCTGCTTGGTCCAGCTAAGAGGGAAGCCTGGCTGCAGTTGAGGGCCGAAATTGAAGCCCTGACCGACT
CCTGGTTGACACTGGCCCTGAAAGCACTCTCGCTCATTCACTCCCGGACAAACTGTGTGAATATTTTAGTAACAACTACTCAGCTCATCCCAGCATTGGC
GAAAGTCCTGCTGTATGGGTTAGGAATTGTATTTCCAATAGAAAATATTTACAGTGCAACTAAAATAGGAAAAGAAAGCTGTTTTGAGAGAATAATTCAA
AGGTTTGGAAGAAAAGTGGTGTATGTTGTTATAGGAGATGGTGTAGAAGAAGAACAAGGAGCAAAAAAGCACGCGATGCCCTTCTGGAGGATCTCCAGCC
ACTCGGACCTCATGGCCCTGCACCATGCCTTGGAACTGGAGTACCTGTAACAGCGCTCGGCACTTTGACAGCGCACAGCTGCTCTGTGACCAGGGACAGA
TCCAGCAGGCCCCAGTCTCGCATCAGCGCCGGCCTCCAGAACTTAGCAATTTCCGCCTGGTGATGCGCAGTTGCTGTCAGTCTTGACCTCTGCCTTTGTG
GTGAATGGAGGACCACGTCTATTTCATCAGAACAGCTGTTGACTCTAGTACTGTGAATCCAGTGAAAATAAGCCATGAGAATGTTTTAGCACAGCGTTAT
GTGTCTGCCACATTAACTACACGGTTCAAACCTGTGAAGAAAGGACCTGCAAACGCTTCAGTTGTTAGCATTTTCAATGTGATATAAACAGCTTCTCCAA
TACAGCAAACCTAATTGCACAACAGAGACTGAAATGTGTTTCCTGAATACCAGTGGAGGAATTTTCTTGTAAAGAAGGTTTACTTTTTGGTGTCTCATAC
CCAGGGTAATCTGTACATCTCTACTTATTTATGAACAGACTTTTTTTAAAAAGATAAAAAAACAGCTTTATTGAGGTATAATTCACCCACCAGACTTTTT
TAAACATCAAATAATTGAAGAGACAATAGCATTAGAAATAAGTGATTAAAGGCCTCTGCCTCACAACATGGCAAGTACAGTACTTTGAATTTTAGCACAT
TGCATAGTAGTTTTAAGTATGTCTAATTTAAACGTATAATATGTACATCACTGAGACAATCATGTACAGAAAGAATTTTTGGTGTAAATTTGTAATAATG
GATAATTCTTTTACATATTGTTTAGGGAAATGATATTGAAAGGTAGCAATGCCTGGATAGTGAAGCATGAGGCAGCACGTGCACAAATTCATGTGCCGTG
CCTTATCTGAGTTTTCGGTATAAATATGTAGATAATGGATTTTTTTTTTTTAGATAATGTTGTCAAGACCAAAAGCATGGATGTCAAGTGTCAGTAAGGA
TTTTGTTTTCTAAAATTTTTTCCTGCATCAGTTCTTCTGAGGGCCTTGATGAAATAACACAGCAGTTTCTTAAACAATTTGAAACAAAATGAGCTCTCCT
ACCACCTCACTTTTTCATTTCCACACTAATGTATTATATGTAACTACTTGGAAAAAATAATTATTCAAATGCTTCTTCCCACAAAGAATATAGATGATAG
TAGATATATTTTATTAATAAAATGGTTCATGAATCGGAGACTAACAAAGTTTTCATGTGCTCAGAATTATTAATTATCGTGTCTGCATTTTCTTTCGATA
AAGGAAGACACACGATGCTAATCCGGAAATCAGCAAACTTTGCATTACTCCCTATGTGCGTATTTTCTCTTTCTTCCTGTCACCCTGAGGAAGGTTCATT
GCCATTGTCATCACCATGGAAACAACGTTCCTCTCCACCTGCATTATGTACTACATGACAGGCATCAATCTGGGGAAATAATAAAATTATCACCTTTGTC
AGACCATAAGAGTTTCTCCAAAAGTGGTCAGTTTGGCTGGGCAATATTTTCTCTCATCTAACAAACACAATCCATTGTCATGAAATTACCCTTAGGATGA
GTCTTCTTTAATCAATCATATATTGGGCGGGAAAAACACCAGCTTTGACCCGAAGTAGTTGAAGAGCTACTTCATTCTTTTCTGAAGTTGTGTGTTGCTG
CTAGAAATAGTCATTTGTGAATTATCCAAATTGTTTAAATTCACAATTGAATTAGTTTTTTCTTCCTTTTTGCTTGAAGCAAACAGTTGACAATTTTTAA
CCTTTTCATTTTATGTTTTTGTACTCTGCAGACTGAAAAGACAAAGTTTATCTTGGCCTTACTGTATAAAGGTGTGCTGTGTCCACCGTTGTGTACAGAA
TTTTTCTTCATTAATTTTGTGTTTAAGTTAATAAAATTTATTTGTGATGTACTGTAA
  • refseq_EYA1.F2 (forward primer)
  • refseq_EYA1.R2 (reverse primer)
  • Single exon skipping

Frame 0

LLFLFWLKESIVVLSHVLCIIKS*H*SRVTTSS
NFFTPDHRCKHLKPVQMLLFPQVAGLWKCRI*PA
RIAV*VVVVNPPVAPNSVTLI*IVIP*LPMAPK
LKQSQ*AAVKQLQRQPTGL*TISQVQQLGAVVS
AHDQLTSSLHHRFTLPTDHTHIFSLPLPHKLWLH
MGKHSLPQECNKLQPMPRTHSQDSRTAFPHMAS
RLKVDCHSLSHLDRQDFSAMAQASVPLNLDRHH
TATRCKVAVLQHHQEYIQEIIHSQIPLDLIVHSR
TIRLIPVLARVSTHSIITAHRIQHII*PAATPA
QRHHPPMPLTSFKNRHLASPAKQLQIPQQSTAQ
STAHQHPLKIQILIDCVEVQMGNHVDGAEETIIL
HLPQILILRECSSGTWMRQSLFSTPCLLGPTPT
DMGGNVTKSI*MMFLQMITDRT*AHITLEQMAF
LLQQPVLTYVWQLVYGAVWTG*ESWPSATDG*KR
STTPTKIMLEVCLVQLRGKPGCS*GPKLKP*PT
PG*HWP*KHSRSFTPGQTV*IF**QLLSSSQHW
RKSCCMG*ELYFQ*KIFTVQLK*EKKAVLRE*FK
GLEEKWCMLL*EMV*KKNKEQKSTRCPSGGSPA
TRTSWPCTMPWNWSTCNSARHFDSAQLLCDQGQ
IQQAPVSHQRRPPELSNFRLVMRSCCQS*PLPLW
*MEDHVYFIRTAVDSSTVNPVKISHENVLAQRY
VSATLTTRFKPVKKGPANASVVSIFNVI*TASP
IQQT*LHNRD*NVFPEYQWRNFLVKKVYFLVSHT
QGNLYISTYL*TDFF*KDKKTALLRYNSPTRLF
*TSNN*RDNSIRNK*LKASASQHGKYSTLNFST
LHSSFKYV*FKRIICTSLRQSCTERIFGVNL**W
IILLHIV*GNDIER*QCLDSEA*GSTCTNSCAV
PYLSFRYKYVDNGFFFFR*CCQDQKHGCQVSVR
ILFSKIFSCISSSEGLDEITQQFLKQFETK*ALL
PPHFFISTLMYYM*LLGKNNYSNASSHKEYR**
*IYFINKMVHESETNKVFMCSELLIIVSAFSFD
KGRHTMLIRKSANFALLPMCVFSLSSCHPEEGSL
PLSSPWKQRSSPPALCTT*QASIWGNNKIITFV
RP*EFLQKWSVWLGNIFSHLTNTIHCHEITLRM
SLL*SIIYWAGKTPALTRSS*RATSFFSEVVCCC
*K*SFVNYPNCLNSQLN*FFLPFCLKQTVDNF*
PFHFMFLYSAD*KDKVYLGLTV*RCAVSTVVYR
IFLH*FCV*VNKIYL*CTV

Frame 1

SFFSFG*KRALSFSAMCSV*LRADTEAE*QHLL
IFLPLITGANISSQFRCCCFLKLQVYGNAGSNQ
PA*PSEW***IPQWPQTR*LSYK**FHDSQWHRS
*NRANEQQ*NSFNDSRRVFKQFLRFSNWEQ*FQ
PTTNSPVLSTTDLPFQQTIPTYSPYPFLTNYGC
IWANTVYHRNATSYSLCHVPTARTAVRHFLIWHQ
D*RWIVTVSVTWTDRISQLWHKLQYPSTWTGTI
QLPDAR*QFYNIIRNIYRK*FTHKFLWI**FTA
GLSVLSQFWPGSVRTVL*QLTVSSTLYDQQQHQP
NDTIHQCHLPASRTAIWHHQPSSYRSHSRVQHN
PQPINTH*RFRF*SIASRFRWEITWTGPKKQ*S
FTSPRF*S*ESVHLGLG*DNHCFPLLAYWVLRQQ
IWEGM*PSPYR*CFFR**RTGPKHI*LWNRWLS
CCSNQC*LMFGNWCTGRCGLDEKVGLPLQTGKR
DLQHLQK*CWRSAWSS*EGSLAAVEGRN*SPDRL
LVDTGPESTLAHSLPDKLCEYFSNNYSAHPSIG
ESPAVWVRNCISNRKYLQCN*NRKRKLF*ENNS
KVWKKSGVCCYRRWCRRRTRSKKARDALLEDLQP
LGPHGPAPCLGTGVPVTALGTLTAHSCSVTRDR
SSRPQSRISAGLQNLAISAW*CAVAVSLDLCLC
GEWRTTSISSEQLLTLVL*IQ*K*AMRMF*HSVM
CLPH*LHGSNL*RKDLQTLQLLAFSM*YKQLLQ
YSKPNCTTETEMCFLNTSGGIFL*RRFTFWCLI
PRVICTSLLIYEQTFFKKIKKQLY*GIIHPPDFF
KHQIIEETIALEISD*RPLPHNMASTVL*ILAH
CIVVLSMSNLNV*YVHH*DNHVQKEFLV*ICNN
G*FFYILFREMILKGSNAWIVKHEAARAQIHVPC
LI*VFGINM*IMDFFFLDNVVKTKSMDVKCQ*G
FCFLKFFPASVLLRALMK*HSSFLNNLKQNELS
YHLTFSFPH*CIICNYLEKIIIQMLLPTKNIDDS
RYILLIKWFMNRRLTKFSCAQNY*LSCLHFLSI
KEDTRC*SGNQQTLHYSLCAYFLFLPVTLRKVH
CHCHHHGNNVPLHLHYVLHDRHQSGEIIKLSPLS
DHKSFSKSGQFGWAIFSLI*QTQSIVMKLPLG*
VFFNQSYIGREKHQL*PEVVEELLHSFLKLCVA
ARNSHL*IIQIV*IHN*ISFFFLFA*SKQLTIFN
LFILCFCTLQTEKTKFILALLYKGVLCPPLCTE
FFFINFVFKLIKFICDVL*

Frame 2

PFSLLVKREHCRSQPCALYN*ELTLKQSNNIF*
FFYP*SQVQTSQASSDVAVSSSCRSMEMQDLTS
PHSRLSGSSESPSGPKLGNSHINSNSMTPNGTE
VKTEPMSSSETASTTADGSLNNFSGSAIGSSSFS
PRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAA
YGQTQFTTGMQQATAYATYPQPGQPYGISSYGI
KTEGGLSQSQSPGQTGFLSYGTSFSTPQPGQAPY
SYQMQGSSFTTSSGIYTGNNSLTNSSGFNSSQQ
DYPSYPSFGQGQYAQYYNSSPYPAHYMTSSNTS
PTTPSTNATYQLQEPPSGITSQAVTDPTAEYSTI
HSPSTPIKDSDSDRLRRGSDGKSRGRGRRNNNP
SPPPDSDLERVFIWDLDETIIVFHSLLTGSYAN
RYGRECDQVHIDDVSSDDNGQDLSTYNFGTDGFP
AAATSANLCLATGVRGGVDWMRKLAFRYRRVKE
IYNTYKNNVGGLLGPAKREAWLQLRAEIEALTD
SWLTLALKALSLIHSRTNCVNILVTTTQLIPALA
KVLLYGLGIVFPIENIYSATKIGKESCFERIIQ
RFGRKVVYVVIGDGVEEEQGAKKHAMPFWRISS
HSDLMALHHALELEYL*QRSAL*QRTAAL*PGTD
PAGPSLASAPASRT*QFPPGDAQLLSVLTSAFV
VNGGPRLFHQNSC*L*YCESSENKP*ECFSTAL
CVCHINYTVQTCEERTCKRFSC*HFQCDINSFSN
TANLIAQQRLKCVS*IPVEEFSCKEGLLFGVSY
PG*SVHLYLFMNRLFLKR*KNSFIEV*FTHQTF
LNIK*LKRQ*H*K*VIKGLCLTTWQVQYFEF*HI
A**F*VCLI*TYNMYITETIMYRKNFWCKFVIM
DNSFTYCLGK*Y*KVAMPG**SMRQHVHKFMCR
ALSEFSV*ICR*WIFFF*IMLSRPKAWMSSVSKD
FVF*NFFLHQFF*GP**NNTAVS*TI*NKMSSP
TTSLFHFHTNVLYVTTWKK*LFKCFFPQRI*MI
VDIFY**NGS*IGD*QSFHVLRIINYRVCIFFR*
RKTHDANPEISKLCITPYVRIFSFFLSP*GRFI
AIVITMETTFLSTCIMYYMTGINLGK**NYHLC
QTIRVSPKVVSLAGQYFLSSNKHNPLS*NYP*DE
SSLINHILGGKNTSFDPK*LKSYFILF*SCVLL
LEIVICELSKLFKFTIELVFSSFLLEANS*QFL
TFSFYVFVLCRLKRQSLSWPYCIKVCCVHRCVQN
FSSLILCLS**NLFVMYC

Sequence NM_172058

CTCCTTTTTCTCTTTTGGTTAAAAGAGAGCATTGTCGTTCTCAGCCATGTGCTCTGTATAATTAAGAGCTGACACTGAAGCAGAGTAACAACATCTTCTA
ATTTTTTTACCCCTGATCACAGGTGCAAACATCTCAAGCCAGTTCAGATGTTGCTGTTTCCTCAAGTTGCAGGTCTATGGAAATGCAGGATCTAACCAGC
CCGCATAGCCGTCTGAGTGGTAGTAGTGAATCCCCCAGTGGCCCCAAACTCGGTAACTCTCATATAAATAGTAATTCCATGACTCCCAATGGCACCGAAG
TTAAAACAGAGCCAATGAGCAGCAGTGAAACAGCTTCAACGACAGCCGACGGGTCTTTAAACAATTTCTCAGGTTCAGCAATTGGGAGCAGTAGTTTCAG
CCCACGACCAACTCACCAGTTCTCTCCACCACAGATTTACCCTTCCAACAGACCATACCCACATATTCTCCCTACCCCTTCCTCACAAACTATGGCTGCA
TATGGGCAAACACAGTTTACCACAGGAATGCAACAAGCTACAGCCTATGCCACGTACCCACAGCCAGGACAGCCGTACGGCATTTCCTCATATGGTGCAT
TGTGGGCAGGCATCAAGACTGAAGGTGGATTGTCACAGTCTCAGTCACCTGGACAGACAGGATTTCTCAGCTATGGCACAAGCTTCAGTACCCCTCAACC
TGGACAGGCACCATACAGCTACCAGATGCAAGGTAGCAGTTTTACAACATCATCAGGAATATATACAGGAAATAATTCACTCACAAATTCCTCTGGATTT
AATAGTTCACAGCAGGACTATCCGTCTTATCCCAGTTTTGGCCAGGGTCAGTACGCACAGTATTATAACAGCTCACCGTATCCAGCACATTATATGACCA
GCAGCAACACCAGCCCAACGACACCATCCACCAATGCCACTTACCAGCTTCAAGAACCGCCATCTGGCATCACCAGCCAAGCAGTTACAGATCCCACAGC
AGAGTACAGCACAATCCACAGCCCATCAACACCCATTAAAGATTCAGATTCTGATCGATTGCGTCGAGGTTCAGATGGGAAATCACGTGGACGGGGCCGA
AGAAACAATAATCCTTCACCTCCCCCAGATTCTGATCTTGAGAGAGTGTTCATCTGGGACTTGGATGAGACAATCATTGTTTTCCACTCCTTGCTTACTG
GGTCCTACGCCAACAGATATGGGAGGGATCCACCCACTTCAGTTTCCCTTGGACTGCGAATGGAAGAAATGATTTTCAACTTGGCAGACACACATTTATT
TTTTAATGACTTAGAAGAATGTGACCAAGTCCATATAGATGATGTTTCTTCAGATGATAACGGACAGGACCTAAGCACATATAACTTTGGAACAGATGGC
TTTCCTGCTGCAGCAACCAGTGCTAACTTATGTTTGGCAACTGGTGTACGGGGCGGTGTGGACTGGATGAGAAAGTTGGCCTTCCGCTACAGACGGGTAA
AAGAGATCTACAACACCTACAAAAATAATGTTGGAGGTCTGCTTGGTCCAGCTAAGAGGGAAGCCTGGCTGCAGTTGAGGGCCGAAATTGAAGCCCTGAC
CGACTCCTGGTTGACACTGGCCCTGAAAGCACTCTCGCTCATTCACTCCCGGACAAACTGTGTGAATATTTTAGTAACAACTACTCAGCTCATCCCAGCA
TTGGCGAAAGTCCTGCTGTATGGGTTAGGAATTGTATTTCCAATAGAAAATATTTACAGTGCAACTAAAATAGGAAAAGAAAGCTGTTTTGAGAGAATAA
TTCAAAGGTTTGGAAGAAAAGTGGTGTATGTTGTTATAGGAGATGGTGTAGAAGAAGAACAAGGAGCAAAAAAGCACGCGATGCCCTTCTGGAGGATCTC
CAGCCACTCGGACCTCATGGCCCTGCACCATGCCTTGGAACTGGAGTACCTGTAACAGCGCTCGGCACTTTGACAGCGCACAGCTGCTCTGTGACCAGGG
ACAGATCCAGCAGGCCCCAGTCTCGCATCAGCGCCGGCCTCCAGAACTTAGCAATTTCCGCCTGGTGATGCGCAGTTGCTGTCAGTCTTGACCTCTGCCT
TTGTGGTGAATGGAGGACCACGTCTATTTCATCAGAACAGCTGTTGACTCTAGTACTGTGAATCCAGTGAAAATAAGCCATGAGAATGTTTTAGCACAGC
GTTATGTGTCTGCCACATTAACTACACGGTTCAAACCTGTGAAGAAAGGACCTGCAAACGCTTCAGTTGTTAGCATTTTCAATGTGATATAAACAGCTTC
TCCAATACAGCAAACCTAATTGCACAACAGAGACTGAAATGTGTTTCCTGAATACCAGTGGAGGAATTTTCTTGTAAAGAAGGTTTACTTTTTGGTGTCT
CATACCCAGGGTAATCTGTACATCTCTACTTATTTATGAACAGACTTTTTTTAAAAAGATAAAAAAACAGCTTTATTGAGGTATAATTCACCCACCAGAC
TTTTTTAAACATCAAATAATTGAAGAGACAATAGCATTAGAAATAAGTGATTAAAGGCCTCTGCCTCACAACATGGCAAGTACAGTACTTTGAATTTTAG
CACATTGCATAGTAGTTTTAAGTATGTCTAATTTAAACGTATAATATGTACATCACTGAGACAATCATGTACAGAAAGAATTTTTGGTGTAAATTTGTAA
TAATGGATAATTCTTTTACATATTGTTTAGGGAAATGATATTGAAAGGTAGCAATGCCTGGATAGTGAAGCATGAGGCAGCACGTGCACAAATTCATGTG
CCGTGCCTTATCTGAGTTTTCGGTATAAATATGTAGATAATGGATTTTTTTTTTTTAGATAATGTTGTCAAGACCAAAAGCATGGATGTCAAGTGTCAGT
AAGGATTTTGTTTTCTAAAATTTTTTCCTGCATCAGTTCTTCTGAGGGCCTTGATGAAATAACACAGCAGTTTCTTAAACAATTTGAAACAAAATGAGCT
CTCCTACCACCTCACTTTTTCATTTCCACACTAATGTATTATATGTAACTACTTGGAAAAAATAATTATTCAAATGCTTCTTCCCACAAAGAATATAGAT
GATAGTAGATATATTTTATTAATAAAATGGTTCATGAATCGGAGACTAACAAAGTTTTCATGTGCTCAGAATTATTAATTATCGTGTCTGCATTTTCTTT
CGATAAAGGAAGACACACGATGCTAATCCGGAAATCAGCAAACTTTGCATTACTCCCTATGTGCGTATTTTCTCTTTCTTCCTGTCACCCTGAGGAAGGT
TCATTGCCATTGTCATCACCATGGAAACAACGTTCCTCTCCACCTGCATTATGTACTACATGACAGGCATCAATCTGGGGAAATAATAAAATTATCACCT
TTGTCAGACCATAAGAGTTTCTCCAAAAGTGGTCAGTTTGGCTGGGCAATATTTTCTCTCATCTAACAAACACAATCCATTGTCATGAAATTACCCTTAG
GATGAGTCTTCTTTAATCAATCATATATTGGGCGGGAAAAACACCAGCTTTGACCCGAAGTAGTTGAAGAGCTACTTCATTCTTTTCTGAAGTTGTGTGT
TGCTGCTAGAAATAGTCATTTGTGAATTATCCAAATTGTTTAAATTCACAATTGAATTAGTTTTTTCTTCCTTTTTGCTTGAAGCAAACAGTTGACAATT
TTTAACCTTTTCATTTTATGTTTTTGTACTCTGCAGACTGAAAAGACAAAGTTTATCTTGGCCTTACTGTATAAAGGTGTGCTGTGTCCACCGTTGTGTA
CAGAATTTTTCTTCATTAATTTTGTGTTTAAGTTAATAAAATTTATTTGTGATGTACTGTAA
  • refseq_EYA1.F2 (forward primer)
  • refseq_EYA1.R2 (reverse primer)
  • Single exon skipping

Frame 0

LLFLFWLKESIVVLSHVLCIIKS*H*SRVTTSS
NFFTPDHRCKHLKPVQMLLFPQVAGLWKCRI*PA
RIAV*VVVVNPPVAPNSVTLI*IVIP*LPMAPK
LKQSQ*AAVKQLQRQPTGL*TISQVQQLGAVVS
AHDQLTSSLHHRFTLPTDHTHIFSLPLPHKLWLH
MGKHSLPQECNKLQPMPRTHSQDSRTAFPHMVH
CGQASRLKVDCHSLSHLDRQDFSAMAQASVPLN
LDRHHTATRCKVAVLQHHQEYIQEIIHSQIPLDL
IVHSRTIRLIPVLARVSTHSIITAHRIQHII*P
AATPAQRHHPPMPLTSFKNRHLASPAKQLQIPQ
QSTAQSTAHQHPLKIQILIDCVEVQMGNHVDGAE
ETIILHLPQILILRECSSGTWMRQSLFSTPCLL
GPTPTDMGGIHPLQFPLDCEWKK*FSTWQTHIY
FLMT*KNVTKSI*MMFLQMITDRT*AHITLEQMA
FLLQQPVLTYVWQLVYGAVWTG*ESWPSATDG*
KRSTTPTKIMLEVCLVQLRGKPGCS*GPKLKP*
PTPG*HWP*KHSRSFTPGQTV*IF**QLLSSSQH
WRKSCCMG*ELYFQ*KIFTVQLK*EKKAVLRE*
FKGLEEKWCMLL*EMV*KKNKEQKSTRCPSGGS
PATRTSWPCTMPWNWSTCNSARHFDSAQLLCDQG
QIQQAPVSHQRRPPELSNFRLVMRSCCQS*PLP
LW*MEDHVYFIRTAVDSSTVNPVKISHENVLAQ
RYVSATLTTRFKPVKKGPANASVVSIFNVI*TAS
PIQQT*LHNRD*NVFPEYQWRNFLVKKVYFLVS
HTQGNLYISTYL*TDFF*KDKKTALLRYNSPTR
LF*TSNN*RDNSIRNK*LKASASQHGKYSTLNFS
TLHSSFKYV*FKRIICTSLRQSCTERIFGVNL*
*WIILLHIV*GNDIER*QCLDSEA*GSTCTNSC
AVPYLSFRYKYVDNGFFFFR*CCQDQKHGCQVSV
RILFSKIFSCISSSEGLDEITQQFLKQFETK*A
LLPPHFFISTLMYYM*LLGKNNYSNASSHKEYR
***IYFINKMVHESETNKVFMCSELLIIVSAFSF
DKGRHTMLIRKSANFALLPMCVFSLSSCHPEEG
SLPLSSPWKQRSSPPALCTT*QASIWGNNKIIT
FVRP*EFLQKWSVWLGNIFSHLTNTIHCHEITLR
MSLL*SIIYWAGKTPALTRSS*RATSFFSEVVC
CC*K*SFVNYPNCLNSQLN*FFLPFCLKQTVDN
F*PFHFMFLYSAD*KDKVYLGLTV*RCAVSTVVY
RIFLH*FCV*VNKIYL*CTV

Frame 1

SFFSFG*KRALSFSAMCSV*LRADTEAE*QHLL
IFLPLITGANISSQFRCCCFLKLQVYGNAGSNQ
PA*PSEW***IPQWPQTR*LSYK**FHDSQWHRS
*NRANEQQ*NSFNDSRRVFKQFLRFSNWEQ*FQ
PTTNSPVLSTTDLPFQQTIPTYSPYPFLTNYGC
IWANTVYHRNATSYSLCHVPTARTAVRHFLIWCI
VGRHQD*RWIVTVSVTWTDRISQLWHKLQYPST
WTGTIQLPDAR*QFYNIIRNIYRK*FTHKFLWI
**FTAGLSVLSQFWPGSVRTVL*QLTVSSTLYDQ
QQHQPNDTIHQCHLPASRTAIWHHQPSSYRSHS
RVQHNPQPINTH*RFRF*SIASRFRWEITWTGP
KKQ*SFTSPRF*S*ESVHLGLG*DNHCFPLLAYW
VLRQQIWEGSTHFSFPWTANGRNDFQLGRHTFI
F**LRRM*PSPYR*CFFR**RTGPKHI*LWNRW
LSCCSNQC*LMFGNWCTGRCGLDEKVGLPLQTGK
RDLQHLQK*CWRSAWSS*EGSLAAVEGRN*SPD
RLLVDTGPESTLAHSLPDKLCEYFSNNYSAHPS
IGESPAVWVRNCISNRKYLQCN*NRKRKLF*ENN
SKVWKKSGVCCYRRWCRRRTRSKKARDALLEDL
QPLGPHGPAPCLGTGVPVTALGTLTAHSCSVTR
DRSSRPQSRISAGLQNLAISAW*CAVAVSLDLCL
CGEWRTTSISSEQLLTLVL*IQ*K*AMRMF*HS
VMCLPH*LHGSNL*RKDLQTLQLLAFSM*YKQL
LQYSKPNCTTETEMCFLNTSGGIFL*RRFTFWCL
IPRVICTSLLIYEQTFFKKIKKQLY*GIIHPPD
FFKHQIIEETIALEISD*RPLPHNMASTVL*IL
AHCIVVLSMSNLNV*YVHH*DNHVQKEFLV*ICN
NG*FFYILFREMILKGSNAWIVKHEAARAQIHV
PCLI*VFGINM*IMDFFFLDNVVKTKSMDVKCQ
*GFCFLKFFPASVLLRALMK*HSSFLNNLKQNEL
SYHLTFSFPH*CIICNYLEKIIIQMLLPTKNID
DSRYILLIKWFMNRRLTKFSCAQNY*LSCLHFL
SIKEDTRC*SGNQQTLHYSLCAYFLFLPVTLRKV
HCHCHHHGNNVPLHLHYVLHDRHQSGEIIKLSP
LSDHKSFSKSGQFGWAIFSLI*QTQSIVMKLPL
G*VFFNQSYIGREKHQL*PEVVEELLHSFLKLCV
AARNSHL*IIQIV*IHN*ISFFFLFA*SKQLTI
FNLFILCFCTLQTEKTKFILALLYKGVLCPPLC
TEFFFINFVFKLIKFICDVL*

Frame 2

PFSLLVKREHCRSQPCALYN*ELTLKQSNNIF*
FFYP*SQVQTSQASSDVAVSSSCRSMEMQDLTS
PHSRLSGSSESPSGPKLGNSHINSNSMTPNGTE
VKTEPMSSSETASTTADGSLNNFSGSAIGSSSFS
PRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAA
YGQTQFTTGMQQATAYATYPQPGQPYGISSYGA
LWAGIKTEGGLSQSQSPGQTGFLSYGTSFSTPQP
GQAPYSYQMQGSSFTTSSGIYTGNNSLTNSSGF
NSSQQDYPSYPSFGQGQYAQYYNSSPYPAHYMT
SSNTSPTTPSTNATYQLQEPPSGITSQAVTDPTA
EYSTIHSPSTPIKDSDSDRLRRGSDGKSRGRGR
RNNNPSPPPDSDLERVFIWDLDETIIVFHSLLT
GSYANRYGRDPPTSVSLGLRMEEMIFNLADTHLF
FNDLEECDQVHIDDVSSDDNGQDLSTYNFGTDG
FPAAATSANLCLATGVRGGVDWMRKLAFRYRRV
KEIYNTYKNNVGGLLGPAKREAWLQLRAEIEALT
DSWLTLALKALSLIHSRTNCVNILVTTTQLIPA
LAKVLLYGLGIVFPIENIYSATKIGKESCFERI
IQRFGRKVVYVVIGDGVEEEQGAKKHAMPFWRIS
SHSDLMALHHALELEYL*QRSAL*QRTAAL*PG
TDPAGPSLASAPASRT*QFPPGDAQLLSVLTSA
FVVNGGPRLFHQNSC*L*YCESSENKP*ECFSTA
LCVCHINYTVQTCEERTCKRFSC*HFQCDINSF
SNTANLIAQQRLKCVS*IPVEEFSCKEGLLFGV
SYPG*SVHLYLFMNRLFLKR*KNSFIEV*FTHQT
FLNIK*LKRQ*H*K*VIKGLCLTTWQVQYFEF*
HIA**F*VCLI*TYNMYITETIMYRKNFWCKFV
IMDNSFTYCLGK*Y*KVAMPG**SMRQHVHKFMC
RALSEFSV*ICR*WIFFF*IMLSRPKAWMSSVS
KDFVF*NFFLHQFF*GP**NNTAVS*TI*NKMS
SPTTSLFHFHTNVLYVTTWKK*LFKCFFPQRI*M
IVDIFY**NGS*IGD*QSFHVLRIINYRVCIFF
R*RKTHDANPEISKLCITPYVRIFSFFLSP*GR
FIAIVITMETTFLSTCIMYYMTGINLGK**NYHL
CQTIRVSPKVVSLAGQYFLSSNKHNPLS*NYP*
DESSLINHILGGKNTSFDPK*LKSYFILF*SCV
LLLEIVICELSKLFKFTIELVFSSFLLEANS*QF
LTFSFYVFVLCRLKRQSLSWPYCIKVCCVHRCV
QNFSSLILCLS**NLFVMYC

Sequence NM_172060

CTCCTTTTTCTCTTTTGGTTAAAAGAGAGCATTGTCGTTCTCAGCCATGTGCTCTGTATAATTAAGAGCTGACACTGAAGCAGAGTAACAACATCTTCTA
ATTTTTTTACCCCTGATCACAGGTGCAAACATCTCAAGCCAGTTCAGATGTTGCTGTTTCCTCAAGTTGCAGTTAAAACAGAGCCAATGAGCAGCAGTGA
AACAGCTTCAACGACAGCCGACGGGTCTTTAAACAATTTCTCAGGTTCAGCAATTGGGAGCAGTAGTTTCAGCCCACGACCAACTCACCAGTTCTCTCCA
CCACAGATTTACCCTTCCAACAGACCATACCCACATATTCTCCCTACCCCTTCCTCACAAACTATGGCTGCATATGGGCAAACACAGTTTACCACAGGAA
TGCAACAAGCTACAGCCTATGCCACGTACCCACAGCCAGGACAGCCGTACGGCATTTCCTCATATGGTGCATTGTGGGCAGGCATCAAGACTGAAGGTGG
ATTGTCACAGTCTCAGTCACCTGGACAGACAGGATTTCTCAGCTATGGCACAAGCTTCAGTACCCCTCAACCTGGACAGGCACCATACAGCTACCAGATG
CAAGGTAGCAGTTTTACAACATCATCAGGAATATATACAGGAAATAATTCACTCACAAATTCCTCTGGATTTAATAGTTCACAGCAGGACTATCCGTCTT
ATCCCAGTTTTGGCCAGGGTCAGTACGCACAGTATTATAACAGCTCACCGTATCCAGCACATTATATGACCAGCAGCAACACCAGCCCAACGACACCATC
CACCAATGCCACTTACCAGCTTCAAGAACCGCCATCTGGCATCACCAGCCAAGCAGTTACAGATCCCACAGCAGAGTACAGCACAATCCACAGCCCATCA
ACACCCATTAAAGATTCAGATTCTGATCGATTGCGTCGAGGTTCAGATGGGAAATCACGTGGACGGGGCCGAAGAAACAATAATCCTTCACCTCCCCCAG
ATTCTGATCTTGAGAGAGTGTTCATCTGGGACTTGGATGAGACAATCATTGTTTTCCACTCCTTGCTTACTGGGTCCTACGCCAACAGATATGGGAGGGA
TCCACCCACTTCAGTTTCCCTTGGACTGCGAATGGAAGAAATGATTTTCAACTTGGCAGACACACATTTATTTTTTAATGACTTAGAAGAATGTGACCAA
GTCCATATAGATGATGTTTCTTCAGATGATAACGGACAGGACCTAAGCACATATAACTTTGGAACAGATGGCTTTCCTGCTGCAGCAACCAGTGCTAACT
TATGTTTGGCAACTGGTGTACGGGGCGGTGTGGACTGGATGAGAAAGTTGGCCTTCCGCTACAGACGGGTAAAAGAGATCTACAACACCTACAAAAATAA
TGTTGGAGGTCTGCTTGGTCCAGCTAAGAGGGAAGCCTGGCTGCAGTTGAGGGCCGAAATTGAAGCCCTGACCGACTCCTGGTTGACACTGGCCCTGAAA
GCACTCTCGCTCATTCACTCCCGGACAAACTGTGTGAATATTTTAGTAACAACTACTCAGCTCATCCCAGCATTGGCGAAAGTCCTGCTGTATGGGTTAG
GAATTGTATTTCCAATAGAAAATATTTACAGTGCAACTAAAATAGGAAAAGAAAGCTGTTTTGAGAGAATAATTCAAAGGTTTGGAAGAAAAGTGGTGTA
TGTTGTTATAGGAGATGGTGTAGAAGAAGAACAAGGAGCAAAAAAGCACGCGATGCCCTTCTGGAGGATCTCCAGCCACTCGGACCTCATGGCCCTGCAC
CATGCCTTGGAACTGGAGTACCTGTAACAGCGCTCGGCACTTTGACAGCGCACAGCTGCTCTGTGACCAGGGACAGATCCAGCAGGCCCCAGTCTCGCAT
CAGCGCCGGCCTCCAGAACTTAGCAATTTCCGCCTGGTGATGCGCAGTTGCTGTCAGTCTTGACCTCTGCCTTTGTGGTGAATGGAGGACCACGTCTATT
TCATCAGAACAGCTGTTGACTCTAGTACTGTGAATCCAGTGAAAATAAGCCATGAGAATGTTTTAGCACAGCGTTATGTGTCTGCCACATTAACTACACG
GTTCAAACCTGTGAAGAAAGGACCTGCAAACGCTTCAGTTGTTAGCATTTTCAATGTGATATAAACAGCTTCTCCAATACAGCAAACCTAATTGCACAAC
AGAGACTGAAATGTGTTTCCTGAATACCAGTGGAGGAATTTTCTTGTAAAGAAGGTTTACTTTTTGGTGTCTCATACCCAGGGTAATCTGTACATCTCTA
CTTATTTATGAACAGACTTTTTTTAAAAAGATAAAAAAACAGCTTTATTGAGGTATAATTCACCCACCAGACTTTTTTAAACATCAAATAATTGAAGAGA
CAATAGCATTAGAAATAAGTGATTAAAGGCCTCTGCCTCACAACATGGCAAGTACAGTACTTTGAATTTTAGCACATTGCATAGTAGTTTTAAGTATGTC
TAATTTAAACGTATAATATGTACATCACTGAGACAATCATGTACAGAAAGAATTTTTGGTGTAAATTTGTAATAATGGATAATTCTTTTACATATTGTTT
AGGGAAATGATATTGAAAGGTAGCAATGCCTGGATAGTGAAGCATGAGGCAGCACGTGCACAAATTCATGTGCCGTGCCTTATCTGAGTTTTCGGTATAA
ATATGTAGATAATGGATTTTTTTTTTTTAGATAATGTTGTCAAGACCAAAAGCATGGATGTCAAGTGTCAGTAAGGATTTTGTTTTCTAAAATTTTTTCC
TGCATCAGTTCTTCTGAGGGCCTTGATGAAATAACACAGCAGTTTCTTAAACAATTTGAAACAAAATGAGCTCTCCTACCACCTCACTTTTTCATTTCCA
CACTAATGTATTATATGTAACTACTTGGAAAAAATAATTATTCAAATGCTTCTTCCCACAAAGAATATAGATGATAGTAGATATATTTTATTAATAAAAT
GGTTCATGAATCGGAGACTAACAAAGTTTTCATGTGCTCAGAATTATTAATTATCGTGTCTGCATTTTCTTTCGATAAAGGAAGACACACGATGCTAATC
CGGAAATCAGCAAACTTTGCATTACTCCCTATGTGCGTATTTTCTCTTTCTTCCTGTCACCCTGAGGAAGGTTCATTGCCATTGTCATCACCATGGAAAC
AACGTTCCTCTCCACCTGCATTATGTACTACATGACAGGCATCAATCTGGGGAAATAATAAAATTATCACCTTTGTCAGACCATAAGAGTTTCTCCAAAA
GTGGTCAGTTTGGCTGGGCAATATTTTCTCTCATCTAACAAACACAATCCATTGTCATGAAATTACCCTTAGGATGAGTCTTCTTTAATCAATCATATAT
TGGGCGGGAAAAACACCAGCTTTGACCCGAAGTAGTTGAAGAGCTACTTCATTCTTTTCTGAAGTTGTGTGTTGCTGCTAGAAATAGTCATTTGTGAATT
ATCCAAATTGTTTAAATTCACAATTGAATTAGTTTTTTCTTCCTTTTTGCTTGAAGCAAACAGTTGACAATTTTTAACCTTTTCATTTTATGTTTTTGTA
CTCTGCAGACTGAAAAGACAAAGTTTATCTTGGCCTTACTGTATAAAGGTGTGCTGTGTCCACCGTTGTGTACAGAATTTTTCTTCATTAATTTTGTGTT
TAAGTTAATAAAATTTATTTGTGATGTACTGTAA
  • refseq_EYA1.F2 (forward primer)
  • refseq_EYA1.R2 (reverse primer)
  • Single exon skipping

Frame 0

LLFLFWLKESIVVLSHVLCIIKS*H*SRVTTSS
NFFTPDHRCKHLKPVQMLLFPQVAVKTEPMSSSE
TASTTADGSLNNFSGSAIGSSSFSPRPTHQFSP
PQIYPSNRPYPHILPTPSSQTMAAYGQTQFTTG
MQQATAYATYPQPGQPYGISSYGALWAGIKTEGG
LSQSQSPGQTGFLSYGTSFSTPQPGQAPYSYQM
QGSSFTTSSGIYTGNNSLTNSSGFNSSQQDYPS
YPSFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPS
TNATYQLQEPPSGITSQAVTDPTAEYSTIHSPS
TPIKDSDSDRLRRGSDGKSRGRGRRNNNPSPPP
DSDLERVFIWDLDETIIVFHSLLTGSYANRYGRD
PPTSVSLGLRMEEMIFNLADTHLFFNDLEECDQ
VHIDDVSSDDNGQDLSTYNFGTDGFPAAATSAN
LCLATGVRGGVDWMRKLAFRYRRVKEIYNTYKNN
VGGLLGPAKREAWLQLRAEIEALTDSWLTLALK
ALSLIHSRTNCVNILVTTTQLIPALAKVLLYGL
GIVFPIENIYSATKIGKESCFERIIQRFGRKVVY
VVIGDGVEEEQGAKKHAMPFWRISSHSDLMALH
HALELEYL*QRSAL*QRTAAL*PGTDPAGPSLA
SAPASRT*QFPPGDAQLLSVLTSAFVVNGGPRLF
HQNSC*L*YCESSENKP*ECFSTALCVCHINYT
VQTCEERTCKRFSC*HFQCDINSFSNTANLIAQ
QRLKCVS*IPVEEFSCKEGLLFGVSYPG*SVHLY
LFMNRLFLKR*KNSFIEV*FTHQTFLNIK*LKR
Q*H*K*VIKGLCLTTWQVQYFEF*HIA**F*VC
LI*TYNMYITETIMYRKNFWCKFVIMDNSFTYCL
GK*Y*KVAMPG**SMRQHVHKFMCRALSEFSV*
ICR*WIFFF*IMLSRPKAWMSSVSKDFVF*NFF
LHQFF*GP**NNTAVS*TI*NKMSSPTTSLFHFH
TNVLYVTTWKK*LFKCFFPQRI*MIVDIFY**N
GS*IGD*QSFHVLRIINYRVCIFFR*RKTHDAN
PEISKLCITPYVRIFSFFLSP*GRFIAIVITMET
TFLSTCIMYYMTGINLGK**NYHLCQTIRVSPK
VVSLAGQYFLSSNKHNPLS*NYP*DESSLINHI
LGGKNTSFDPK*LKSYFILF*SCVLLLEIVICEL
SKLFKFTIELVFSSFLLEANS*QFLTFSFYVFV
LCRLKRQSLSWPYCIKVCCVHRCVQNFSSLILC
LS**NLFVMYC

Frame 1

SFFSFG*KRALSFSAMCSV*LRADTEAE*QHLL
IFLPLITGANISSQFRCCCFLKLQLKQSQ*AAV
KQLQRQPTGL*TISQVQQLGAVVSAHDQLTSSLH
HRFTLPTDHTHIFSLPLPHKLWLHMGKHSLPQE
CNKLQPMPRTHSQDSRTAFPHMVHCGQASRLKV
DCHSLSHLDRQDFSAMAQASVPLNLDRHHTATRC
KVAVLQHHQEYIQEIIHSQIPLDLIVHSRTIRL
IPVLARVSTHSIITAHRIQHII*PAATPAQRHH
PPMPLTSFKNRHLASPAKQLQIPQQSTAQSTAHQ
HPLKIQILIDCVEVQMGNHVDGAEETIILHLPQ
ILILRECSSGTWMRQSLFSTPCLLGPTPTDMGG
IHPLQFPLDCEWKK*FSTWQTHIYFLMT*KNVTK
SI*MMFLQMITDRT*AHITLEQMAFLLQQPVLT
YVWQLVYGAVWTG*ESWPSATDG*KRSTTPTKI
MLEVCLVQLRGKPGCS*GPKLKP*PTPG*HWP*K
HSRSFTPGQTV*IF**QLLSSSQHWRKSCCMG*
ELYFQ*KIFTVQLK*EKKAVLRE*FKGLEEKWC
MLL*EMV*KKNKEQKSTRCPSGGSPATRTSWPCT
MPWNWSTCNSARHFDSAQLLCDQGQIQQAPVSH
QRRPPELSNFRLVMRSCCQS*PLPLW*MEDHVY
FIRTAVDSSTVNPVKISHENVLAQRYVSATLTTR
FKPVKKGPANASVVSIFNVI*TASPIQQT*LHN
RD*NVFPEYQWRNFLVKKVYFLVSHTQGNLYIS
TYL*TDFF*KDKKTALLRYNSPTRLF*TSNN*RD
NSIRNK*LKASASQHGKYSTLNFSTLHSSFKYV
*FKRIICTSLRQSCTERIFGVNL**WIILLHIV
*GNDIER*QCLDSEA*GSTCTNSCAVPYLSFRYK
YVDNGFFFFR*CCQDQKHGCQVSVRILFSKIFS
CISSSEGLDEITQQFLKQFETK*ALLPPHFFIS
TLMYYM*LLGKNNYSNASSHKEYR***IYFINKM
VHESETNKVFMCSELLIIVSAFSFDKGRHTMLI
RKSANFALLPMCVFSLSSCHPEEGSLPLSSPWK
QRSSPPALCTT*QASIWGNNKIITFVRP*EFLQK
WSVWLGNIFSHLTNTIHCHEITLRMSLL*SIIY
WAGKTPALTRSS*RATSFFSEVVCCC*K*SFVN
YPNCLNSQLN*FFLPFCLKQTVDNF*PFHFMFLY
SAD*KDKVYLGLTV*RCAVSTVVYRIFLH*FCV
*VNKIYL*CTV

Frame 2

PFSLLVKREHCRSQPCALYN*ELTLKQSNNIF*
FFYP*SQVQTSQASSDVAVSSSCS*NRANEQQ*
NSFNDSRRVFKQFLRFSNWEQ*FQPTTNSPVLS
TTDLPFQQTIPTYSPYPFLTNYGCIWANTVYHRN
ATSYSLCHVPTARTAVRHFLIWCIVGRHQD*RW
IVTVSVTWTDRISQLWHKLQYPSTWTGTIQLPD
AR*QFYNIIRNIYRK*FTHKFLWI**FTAGLSVL
SQFWPGSVRTVL*QLTVSSTLYDQQQHQPNDTI
HQCHLPASRTAIWHHQPSSYRSHSRVQHNPQPI
NTH*RFRF*SIASRFRWEITWTGPKKQ*SFTSPR
F*S*ESVHLGLG*DNHCFPLLAYWVLRQQIWEG
STHFSFPWTANGRNDFQLGRHTFIF**LRRM*P
SPYR*CFFR**RTGPKHI*LWNRWLSCCSNQC*L
MFGNWCTGRCGLDEKVGLPLQTGKRDLQHLQK*
CWRSAWSS*EGSLAAVEGRN*SPDRLLVDTGPE
STLAHSLPDKLCEYFSNNYSAHPSIGESPAVWVR
NCISNRKYLQCN*NRKRKLF*ENNSKVWKKSGV
CCYRRWCRRRTRSKKARDALLEDLQPLGPHGPA
PCLGTGVPVTALGTLTAHSCSVTRDRSSRPQSRI
SAGLQNLAISAW*CAVAVSLDLCLCGEWRTTSI
SSEQLLTLVL*IQ*K*AMRMF*HSVMCLPH*LH
GSNL*RKDLQTLQLLAFSM*YKQLLQYSKPNCTT
ETEMCFLNTSGGIFL*RRFTFWCLIPRVICTSL
LIYEQTFFKKIKKQLY*GIIHPPDFFKHQIIEE
TIALEISD*RPLPHNMASTVL*ILAHCIVVLSMS
NLNV*YVHH*DNHVQKEFLV*ICNNG*FFYILF
REMILKGSNAWIVKHEAARAQIHVPCLI*VFGI
NM*IMDFFFLDNVVKTKSMDVKCQ*GFCFLKFFP
ASVLLRALMK*HSSFLNNLKQNELSYHLTFSFP
H*CIICNYLEKIIIQMLLPTKNIDDSRYILLIK
WFMNRRLTKFSCAQNY*LSCLHFLSIKEDTRC*S
GNQQTLHYSLCAYFLFLPVTLRKVHCHCHHHGN
NVPLHLHYVLHDRHQSGEIIKLSPLSDHKSFSK
SGQFGWAIFSLI*QTQSIVMKLPLG*VFFNQSYI
GREKHQL*PEVVEELLHSFLKLCVAARNSHL*I
IQIV*IHN*ISFFFLFA*SKQLTIFNLFILCFC
TLQTEKTKFILALLYKGVLCPPLCTEFFFINFVF
KLIKFICDVL*

Sequence NM_000503

AAACCAATAAGGTTAGGACAAGAGAATAGCTGTGGTTTGCGTTGCAAAAACCAAAAAAAAAAAAAAAAAAAAAAAAAGAAAGCCCCGAGGCTCCATGGGC
AGACCTACAAGGCTGCGCAAACAAATCGAGGGATGAGATTCTGCTGTTTCTTTGTCTAGGGTTCTCAGATGCTATCTGCCGCTGCTGTTTGGTGGGGAAG
GAGCGCTGGGCGCAAAGCTGTTACCAAACAGAACGGTGGGAGCTGATGGCTCCGAGTTTGGGGCGAGGTAGAAACTCTCCAGTGCCACTTCCGACTTTAA
GCCTTCCTGTTGCCGTCCACTGTGGCGGGTTTCTTCCTGGGGAACACGTTTTCGCTCAGTCGCTCGGCAGCCCGAGCCTGCGGCAGCGGCCAGGCGCCTG
CCCCCTGCGCCGAGCTTTCCCCTGCAGAGGCGCTCCACTCCCAGAAGCGCCGCGGCTGCACCAGAGCGCCTGAGAGCCCCCGCGCGTACCCATCCAGGAG
CAAAACTATGTCAGGAATGGAGGTTTGCTAACCCAGAAAATTCGAAGGAACACATTAAACTGGTGGATGCAGCAGATGTAAGCGCTGTGCAAACATCTCA
AGCCAGTTCAGATGTTGCTGTTTCCTCAAGTTGCAGGTCTATGGAAATGCAGGATCTAACCAGCCCGCATAGCCGTCTGAGTGGTAGTAGTGAATCCCCC
AGTGGCCCCAAACTCGGTAACTCTCATATAAATAGTAATTCCATGACTCCCAATGGCACCGAAGTTAAAACAGAGCCAATGAGCAGCAGTGAAACAGCTT
CAACGACAGCCGACGGGTCTTTAAACAATTTCTCAGGTTCAGCAATTGGGAGCAGTAGTTTCAGCCCACGACCAACTCACCAGTTCTCTCCACCACAGAT
TTACCCTTCCAACAGACCATACCCACATATTCTCCCTACCCCTTCCTCACAAACTATGGCTGCATATGGGCAAACACAGTTTACCACAGGAATGCAACAA
GCTACAGCCTATGCCACGTACCCACAGCCAGGACAGCCGTACGGCATTTCCTCATATGGTGCATTGTGGGCAGGCATCAAGACTGAAGGTGGATTGTCAC
AGTCTCAGTCACCTGGACAGACAGGATTTCTCAGCTATGGCACAAGCTTCAGTACCCCTCAACCTGGACAGGCACCATACAGCTACCAGATGCAAGGTAG
CAGTTTTACAACATCATCAGGAATATATACAGGAAATAATTCACTCACAAATTCCTCTGGATTTAATAGTTCACAGCAGGACTATCCGTCTTATCCCAGT
TTTGGCCAGGGTCAGTACGCACAGTATTATAACAGCTCACCGTATCCAGCACATTATATGACCAGCAGCAACACCAGCCCAACGACACCATCCACCAATG
CCACTTACCAGCTTCAAGAACCGCCATCTGGCATCACCAGCCAAGCAGTTACAGATCCCACAGCAGAGTACAGCACAATCCACAGCCCATCAACACCCAT
TAAAGATTCAGATTCTGATCGATTGCGTCGAGGTTCAGATGGGAAATCACGTGGACGGGGCCGAAGAAACAATAATCCTTCACCTCCCCCAGATTCTGAT
CTTGAGAGAGTGTTCATCTGGGACTTGGATGAGACAATCATTGTTTTCCACTCCTTGCTTACTGGGTCCTACGCCAACAGATATGGGAGGGATCCACCCA
CTTCAGTTTCCCTTGGACTGCGAATGGAAGAAATGATTTTCAACTTGGCAGACACACATTTATTTTTTAATGACTTAGAAGAATGTGACCAAGTCCATAT
AGATGATGTTTCTTCAGATGATAACGGACAGGACCTAAGCACATATAACTTTGGAACAGATGGCTTTCCTGCTGCAGCAACCAGTGCTAACTTATGTTTG
GCAACTGGTGTACGGGGCGGTGTGGACTGGATGAGAAAGTTGGCCTTCCGCTACAGACGGGTAAAAGAGATCTACAACACCTACAAAAATAATGTTGGAG
GTCTGCTTGGTCCAGCTAAGAGGGAAGCCTGGCTGCAGTTGAGGGCCGAAATTGAAGCCCTGACCGACTCCTGGTTGACACTGGCCCTGAAAGCACTCTC
GCTCATTCACTCCCGGACAAACTGTGTGAATATTTTAGTAACAACTACTCAGCTCATCCCAGCATTGGCGAAAGTCCTGCTGTATGGGTTAGGAATTGTA
TTTCCAATAGAAAATATTTACAGTGCAACTAAAATAGGAAAAGAAAGCTGTTTTGAGAGAATAATTCAAAGGTTTGGAAGAAAAGTGGTGTATGTTGTTA
TAGGAGATGGTGTAGAAGAAGAACAAGGAGCAAAAAAGCACGCGATGCCCTTCTGGAGGATCTCCAGCCACTCGGACCTCATGGCCCTGCACCATGCCTT
GGAACTGGAGTACCTGTAACAGCGCTCGGCACTTTGACAGCGCACAGCTGCTCTGTGACCAGGGACAGATCCAGCAGGCCCCAGTCTCGCATCAGCGCCG
GCCTCCAGAACTTAGCAATTTCCGCCTGGTGATGCGCAGTTGCTGTCAGTCTTGACCTCTGCCTTTGTGGTGAATGGAGGACCACGTCTATTTCATCAGA
ACAGCTGTTGACTCTAGTACTGTGAATCCAGTGAAAATAAGCCATGAGAATGTTTTAGCACAGCGTTATGTGTCTGCCACATTAACTACACGGTTCAAAC
CTGTGAAGAAAGGACCTGCAAACGCTTCAGTTGTTAGCATTTTCAATGTGATATAAACAGCTTCTCCAATACAGCAAACCTAATTGCACAACAGAGACTG
AAATGTGTTTCCTGAATACCAGTGGAGGAATTTTCTTGTAAAGAAGGTTTACTTTTTGGTGTCTCATACCCAGGGTAATCTGTACATCTCTACTTATTTA
TGAACAGACTTTTTTTAAAAAGATAAAAAAACAGCTTTATTGAGGTATAATTCACCCACCAGACTTTTTTAAACATCAAATAATTGAAGAGACAATAGCA
TTAGAAATAAGTGATTAAAGGCCTCTGCCTCACAACATGGCAAGTACAGTACTTTGAATTTTAGCACATTGCATAGTAGTTTTAAGTATGTCTAATTTAA
ACGTATAATATGTACATCACTGAGACAATCATGTACAGAAAGAATTTTTGGTGTAAATTTGTAATAATGGATAATTCTTTTACATATTGTTTAGGGAAAT
GATATTGAAAGGTAGCAATGCCTGGATAGTGAAGCATGAGGCAGCACGTGCACAAATTCATGTGCCGTGCCTTATCTGAGTTTTCGGTATAAATATGTAG
ATAATGGATTTTTTTTTTTTAGATAATGTTGTCAAGACCAAAAGCATGGATGTCAAGTGTCAGTAAGGATTTTGTTTTCTAAAATTTTTTCCTGCATCAG
TTCTTCTGAGGGCCTTGATGAAATAACACAGCAGTTTCTTAAACAATTTGAAACAAAATGAGCTCTCCTACCACCTCACTTTTTCATTTCCACACTAATG
TATTATATGTAACTACTTGGAAAAAATAATTATTCAAATGCTTCTTCCCACAAAGAATATAGATGATAGTAGATATATTTTATTAATAAAATGGTTCATG
AATCGGAGACTAACAAAGTTTTCATGTGCTCAGAATTATTAATTATCGTGTCTGCATTTTCTTTCGATAAAGGAAGACACACGATGCTAATCCGGAAATC
AGCAAACTTTGCATTACTCCCTATGTGCGTATTTTCTCTTTCTTCCTGTCACCCTGAGGAAGGTTCATTGCCATTGTCATCACCATGGAAACAACGTTCC
TCTCCACCTGCATTATGTACTACATGACAGGCATCAATCTGGGGAAATAATAAAATTATCACCTTTGTCAGACCATAAGAGTTTCTCCAAAAGTGGTCAG
TTTGGCTGGGCAATATTTTCTCTCATCTAACAAACACAATCCATTGTCATGAAATTACCCTTAGGATGAGTCTTCTTTAATCAATCATATATTGGGCGGG
AAAAACACCAGCTTTGACCCGAAGTAGTTGAAGAGCTACTTCATTCTTTTCTGAAGTTGTGTGTTGCTGCTAGAAATAGTCATTTGTGAATTATCCAAAT
TGTTTAAATTCACAATTGAATTAGTTTTTTCTTCCTTTTTGCTTGAAGCAAACAGTTGACAATTTTTAACCTTTTCATTTTATGTTTTTGTACTCTGCAG
ACTGAAAAGACAAAGTTTATCTTGGCCTTACTGTATAAAGGTGTGCTGTGTCCACCGTTGTGTACAGAATTTTTCTTCATTAATTTTGTGTTTAAGTTAA
TAAAATTTATTTGTGATGTACTGTAA
  • refseq_EYA1.F2 (forward primer)
  • refseq_EYA1.R2 (reverse primer)
  • Single exon skipping

Frame 0

KPIRLGQENSCGLRCKNQKKKKKKKKKAPRLHG
QTYKAAQTNRGMRFCCFFV*GSQMLSAAAVWWGR
SAGRKAVTKQNGGS*WLRVWGEVETLQCHFRL*
AFLLPSTVAGFFLGNTFSLSRSAARACGSGQAP
APCAELSPAEALHSQKRRGCTRAPESPRAYPSRS
KTMSGMEVC*PRKFEGTH*TGGCSRCKRCANIS
SQFRCCCFLKLQVYGNAGSNQPA*PSEW***IP
QWPQTR*LSYK**FHDSQWHRS*NRANEQQ*NSF
NDSRRVFKQFLRFSNWEQ*FQPTTNSPVLSTTD
LPFQQTIPTYSPYPFLTNYGCIWANTVYHRNAT
SYSLCHVPTARTAVRHFLIWCIVGRHQD*RWIVT
VSVTWTDRISQLWHKLQYPSTWTGTIQLPDAR*
QFYNIIRNIYRK*FTHKFLWI**FTAGLSVLSQ
FWPGSVRTVL*QLTVSSTLYDQQQHQPNDTIHQC
HLPASRTAIWHHQPSSYRSHSRVQHNPQPINTH
*RFRF*SIASRFRWEITWTGPKKQ*SFTSPRF*
S*ESVHLGLG*DNHCFPLLAYWVLRQQIWEGSTH
FSFPWTANGRNDFQLGRHTFIF**LRRM*PSPY
R*CFFR**RTGPKHI*LWNRWLSCCSNQC*LMF
GNWCTGRCGLDEKVGLPLQTGKRDLQHLQK*CWR
SAWSS*EGSLAAVEGRN*SPDRLLVDTGPESTL
AHSLPDKLCEYFSNNYSAHPSIGESPAVWVRNC
ISNRKYLQCN*NRKRKLF*ENNSKVWKKSGVCCY
RRWCRRRTRSKKARDALLEDLQPLGPHGPAPCL
GTGVPVTALGTLTAHSCSVTRDRSSRPQSRISA
GLQNLAISAW*CAVAVSLDLCLCGEWRTTSISSE
QLLTLVL*IQ*K*AMRMF*HSVMCLPH*LHGSN
L*RKDLQTLQLLAFSM*YKQLLQYSKPNCTTET
EMCFLNTSGGIFL*RRFTFWCLIPRVICTSLLIY
EQTFFKKIKKQLY*GIIHPPDFFKHQIIEETIA
LEISD*RPLPHNMASTVL*ILAHCIVVLSMSNL
NV*YVHH*DNHVQKEFLV*ICNNG*FFYILFREM
ILKGSNAWIVKHEAARAQIHVPCLI*VFGINM*
IMDFFFLDNVVKTKSMDVKCQ*GFCFLKFFPAS
VLLRALMK*HSSFLNNLKQNELSYHLTFSFPH*C
IICNYLEKIIIQMLLPTKNIDDSRYILLIKWFM
NRRLTKFSCAQNY*LSCLHFLSIKEDTRC*SGN
QQTLHYSLCAYFLFLPVTLRKVHCHCHHHGNNVP
LHLHYVLHDRHQSGEIIKLSPLSDHKSFSKSGQ
FGWAIFSLI*QTQSIVMKLPLG*VFFNQSYIGR
EKHQL*PEVVEELLHSFLKLCVAARNSHL*IIQI
V*IHN*ISFFFLFA*SKQLTIFNLFILCFCTLQ
TEKTKFILALLYKGVLCPPLCTEFFFINFVFKL
IKFICDVL*

Frame 1

NQ*G*DKRIAVVCVAKTKKKKKKKKRKPRGSMG
RPTRLRKQIEG*DSAVSLSRVLRCYLPLLFGGE
GALGAKLLPNRTVGADGSEFGAR*KLSSATSDFK
PSCCRPLWRVSSWGTRFRSVARQPEPAAAARRL
PPAPSFPLQRRSTPRSAAAAPERLRAPARTHPG
AKLCQEWRFANPENSKEHIKLVDAADVSAVQTSQ
ASSDVAVSSSCRSMEMQDLTSPHSRLSGSSESP
SGPKLGNSHINSNSMTPNGTEVKTEPMSSSETA
STTADGSLNNFSGSAIGSSSFSPRPTHQFSPPQI
YPSNRPYPHILPTPSSQTMAAYGQTQFTTGMQQ
ATAYATYPQPGQPYGISSYGALWAGIKTEGGLS
QSQSPGQTGFLSYGTSFSTPQPGQAPYSYQMQGS
SFTTSSGIYTGNNSLTNSSGFNSSQQDYPSYPS
FGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTN
ATYQLQEPPSGITSQAVTDPTAEYSTIHSPSTPI
KDSDSDRLRRGSDGKSRGRGRRNNNPSPPPDSD
LERVFIWDLDETIIVFHSLLTGSYANRYGRDPP
TSVSLGLRMEEMIFNLADTHLFFNDLEECDQVHI
DDVSSDDNGQDLSTYNFGTDGFPAAATSANLCL
ATGVRGGVDWMRKLAFRYRRVKEIYNTYKNNVG
GLLGPAKREAWLQLRAEIEALTDSWLTLALKALS
LIHSRTNCVNILVTTTQLIPALAKVLLYGLGIV
FPIENIYSATKIGKESCFERIIQRFGRKVVYVV
IGDGVEEEQGAKKHAMPFWRISSHSDLMALHHAL
ELEYL*QRSAL*QRTAAL*PGTDPAGPSLASAP
ASRT*QFPPGDAQLLSVLTSAFVVNGGPRLFHQ
NSC*L*YCESSENKP*ECFSTALCVCHINYTVQT
CEERTCKRFSC*HFQCDINSFSNTANLIAQQRL
KCVS*IPVEEFSCKEGLLFGVSYPG*SVHLYLF
MNRLFLKR*KNSFIEV*FTHQTFLNIK*LKRQ*H
*K*VIKGLCLTTWQVQYFEF*HIA**F*VCLI*
TYNMYITETIMYRKNFWCKFVIMDNSFTYCLGK
*Y*KVAMPG**SMRQHVHKFMCRALSEFSV*ICR
*WIFFF*IMLSRPKAWMSSVSKDFVF*NFFLHQ
FF*GP**NNTAVS*TI*NKMSSPTTSLFHFHTN
VLYVTTWKK*LFKCFFPQRI*MIVDIFY**NGS*
IGD*QSFHVLRIINYRVCIFFR*RKTHDANPEI
SKLCITPYVRIFSFFLSP*GRFIAIVITMETTF
LSTCIMYYMTGINLGK**NYHLCQTIRVSPKVVS
LAGQYFLSSNKHNPLS*NYP*DESSLINHILGG
KNTSFDPK*LKSYFILF*SCVLLLEIVICELSK
LFKFTIELVFSSFLLEANS*QFLTFSFYVFVLCR
LKRQSLSWPYCIKVCCVHRCVQNFSSLILCLS*
*NLFVMYC

Frame 2

TNKVRTRE*LWFALQKPKKKKKKKKESPEAPWA
DLQGCANKSRDEILLFLCLGFSDAICRCCLVGK
ERWAQSCYQTERWELMAPSLGRGRNSPVPLPTL
SLPVAVHCGGFLPGEHVFAQSLGSPSLRQRPGAC
PLRRAFPCRGAPLPEAPRLHQSA*EPPRVPIQE
QNYVRNGGLLTQKIRRNTLNWWMQQM*ALCKHL
KPVQMLLFPQVAGLWKCRI*PARIAV*VVVVNPP
VAPNSVTLI*IVIP*LPMAPKLKQSQ*AAVKQL
QRQPTGL*TISQVQQLGAVVSAHDQLTSSLHHR
FTLPTDHTHIFSLPLPHKLWLHMGKHSLPQECNK
LQPMPRTHSQDSRTAFPHMVHCGQASRLKVDCH
SLSHLDRQDFSAMAQASVPLNLDRHHTATRCKV
AVLQHHQEYIQEIIHSQIPLDLIVHSRTIRLIPV
LARVSTHSIITAHRIQHII*PAATPAQRHHPPM
PLTSFKNRHLASPAKQLQIPQQSTAQSTAHQHP
LKIQILIDCVEVQMGNHVDGAEETIILHLPQILI
LRECSSGTWMRQSLFSTPCLLGPTPTDMGGIHP
LQFPLDCEWKK*FSTWQTHIYFLMT*KNVTKSI
*MMFLQMITDRT*AHITLEQMAFLLQQPVLTYVW
QLVYGAVWTG*ESWPSATDG*KRSTTPTKIMLE
VCLVQLRGKPGCS*GPKLKP*PTPG*HWP*KHS
RSFTPGQTV*IF**QLLSSSQHWRKSCCMG*ELY
FQ*KIFTVQLK*EKKAVLRE*FKGLEEKWCMLL
*EMV*KKNKEQKSTRCPSGGSPATRTSWPCTMP
WNWSTCNSARHFDSAQLLCDQGQIQQAPVSHQRR
PPELSNFRLVMRSCCQS*PLPLW*MEDHVYFIR
TAVDSSTVNPVKISHENVLAQRYVSATLTTRFK
PVKKGPANASVVSIFNVI*TASPIQQT*LHNRD*
NVFPEYQWRNFLVKKVYFLVSHTQGNLYISTYL
*TDFF*KDKKTALLRYNSPTRLF*TSNN*RDNS
IRNK*LKASASQHGKYSTLNFSTLHSSFKYV*FK
RIICTSLRQSCTERIFGVNL**WIILLHIV*GN
DIER*QCLDSEA*GSTCTNSCAVPYLSFRYKYV
DNGFFFFR*CCQDQKHGCQVSVRILFSKIFSCIS
SSEGLDEITQQFLKQFETK*ALLPPHFFISTLM
YYM*LLGKNNYSNASSHKEYR***IYFINKMVH
ESETNKVFMCSELLIIVSAFSFDKGRHTMLIRKS
ANFALLPMCVFSLSSCHPEEGSLPLSSPWKQRS
SPPALCTT*QASIWGNNKIITFVRP*EFLQKWS
VWLGNIFSHLTNTIHCHEITLRMSLL*SIIYWAG
KTPALTRSS*RATSFFSEVVCCC*K*SFVNYPN
CLNSQLN*FFLPFCLKQTVDNF*PFHFMFLYSA
D*KDKVYLGLTV*RCAVSTVVYRIFLH*FCV*VN
KIYL*CTV

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