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Sequences

Sequence NM_001039716

GAGCTTACTCTGGCTTTGCCGAGATGGGGCTGCCCCAGCCAGGGCTGTGGCTGAAGAGGCTCTGGGTGCTCTTGGAGGTGGCTGTGCATGTGGTCGTGGG TAAAGTGCTTCTGATATTGTTTCCAGACAGAGTCAAGCGGAACATCCTGGCCATGGGCGAGAAGACGGGTATGACCAGGAACCCCCATTTCAGCCACGAC AACTGGATACCAACCTTTTTCAGCACCCAGTATTTCTGGTTCGTCTTGAAGGTCCGTTGGCAGCGACTAGAGGACACGACTGAGCTAGGGGGTCTGGCCC CAAACTGCCCGGTGGTCCGCCTCTCAGGACAGAGGTGCAACATTTGGGAGTTTATGCAAGGTAATAGGCCACTGGTGCTGAATTTTGGAAGTTGTACCTG ACCTTCATTTATGTTCAAATTTGACCAGTTCAAGAGGCTTATTGAAGACTTTAGTTCCATAGCAGATTTTCTTGTCATTTACATTGAAGAAGCACATGCA TCAGGGTAAATCTGGCCCTTGGAACTACAACCCAGAGGAAGTTCGTGCTGTTCTGGAAAAGCTCCACAGTTAATCTGGACAGATACCTCAATTCTAGGTG ACCAACGGGAGGGCTTCTCAAGGCTTAGCTCTCCCTGAGACCCAGCTGGCTTTTACCCTTGACCTGTGTCCCTAGCTGAATCACTAGCTCAGATTTTTCT GATCTAAGCAAACAACTCCCAGCTGAGGAATGCAGGCCACAGCACCCAATCAAGACAAATTGTTATTATCAGAAAATGAAGCAACACTTGAGCTGTTCAG GCCAGTTCCCTGTTGAAGAAACAGTTCCCTGTTGAAGAAAGTAGAGCCTGACACTGCTCCCACTTTGGAGACCACATTCCCTGCACACGGTCTTTGAGAG AGCAGTTGCACTCTACAGGCACACTTCTGAGGTACGGTATCTCTCTCCAGCCACTCTGATACCAAGTAATTCAAGCTGGCATTCCTTCTATTAGGGAAAT TCATTTTACCCAATTTGCATTTATGGAATTGATCATTTAAGACACTAAATTAGTTTTTAGAACCAATTATGGGAAGAATTCCAGTTGTTAGGAAGAGATG AGGAGTTGGAAGAGGAGGGATTAGAAACAGGAGGAGGCAGTCATCCTCTCCTTGCCAAAAGATTTAAACCTGTCCACATTGGTGGTGATGATGGGTGAGT TTCCATGGTAACACATCCCTAATTTTACCAGGGAAGAGGAGAGTACTCACTTTACCATCTTTGAATATATTTCATAGAAATCTAGCTCTCTGTACCCTGA AATCTTCCACTAGCCTCACTTTTCAACAGAGTCATCTAGAAGGGAGGGTTGGCTTCCCAAAAGCATAACCTTGACCAAACCAAACAATAGGCACCAGCAA TGCTGTCATTCAGTTATGCAGAAGCTCATTTGTGAAATTCTGTTTCTCTGATTTCTTCGCAAGTCTCTTAATGGTCATTTGTGTTAGATTACATCAAACT GATGGATAGCCATTGGTATTCATCTATTTTAACTCTGTGTCTTTACATATTTGTTTATGATGGCCACAGCCTAAAGTACACACGGCTGTGACTTGATTCA AAAGAAAATGTTATAAGATGCAGTAAACTAATAACAGAATTATTAAAATATATCAGGCTA

refseq_DIO1.F4 (forward primer)
refseq_DIO1.R4 (reverse primer)
Single exon skipping

Frame 0

ELTLALPRWGCPSQGCG*RGSGCSWRWLCMWSW VKCF*YCFQTESSGTSWPWARRRV*PGTPISATT TGYQPFSAPSISGSS*RSVGSD*RTRLS*GVWP QTARWSASQDRGATFGSLCKVIGHWC*ILEVVP DLHLCSNLTSSRGLLKTLVP*QIFLSFTLKKHMH QGKSGPWNYNPEEVRAVLEKLHS*SGQIPQF*V TNGRASQGLALPETQLAFTLDLCP*LNH*LRFF *SKQTTPS*GMQATAPNQDKLLLSENEATLELFR PVPC*RNSSLLKKVEPDTAPTLETTFPAHGL*E SSCTLQAHF*GTVSLSSHSDTK*FKLAFLLLGK FILPNLHLWN*SFKTLN*FLEPIMGRIPVVRKR* GVGRGGIRNRRRQSSSPCQKI*TCPHWW**WVS FHGNTSLILPGKRRVLTLPSLNIFHRNLALCTL KSSTSLTFQQSHLEGRVGFPKA*P*PNQTIGTSN AVIQLCRSSFVKFCFSDFFASLLMVICVRLHQT DG*PLVFIYFNSVSLHICL*WPQPKVHTAVT*F KRKCYKMQ*TNNRIIKIYQA

Frame 1

SLLWLCRDGAAPARAVAEEALGALGGGCACGRG *SASDIVSRQSQAEHPGHGREDGYDQEPPFQPR QLDTNLFQHPVFLVRLEGPLAATRGHD*ARGSGP KLPGGPPLRTEVQHLGVYAR**ATGAEFWKLYL TFIYVQI*PVQEAY*RL*FHSRFSCHLH*RSTC IRVNLALGTTTQRKFVLFWKSSTVNLDRYLNSR* PTGGLLKA*LSLRPSWLLPLTCVPS*ITSSDFS DLSKQLPAEECRPQHPIKTNCYYQKMKQHLSCS GQFPVEETVPC*RK*SLTLLPLWRPHSLHTVFER AVALYRHTSEVRYLSPATLIPSNSSWHSFY*GN SFYPICIYGIDHLRH*ISF*NQLWEEFQLLGRD EELEEEGLETGGGSHPLLAKRFKPVHIGGDDG*V SMVTHP*FYQGRGEYSLYHL*IYFIEI*LSVP* NLPLASLFNRVI*KGGLASQKHNLDQTKQ*APA MLSFSYAEAHL*NSVSLISSQVS*WSFVLDYIKL MDSHWYSSILTLCLYIFVYDGHSLKYTRL*LDS KENVIRCSKLITELLKYIRL

Frame 2

AYSGFAEMGLPQPGLWLKRLWVLLEVAVHVVVG KVLLILFPDRVKRNILAMGEKTGMTRNPHFSHD NWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLA PNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCT* PSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHA SG*IWPLELQPRGSSCCSGKAPQLIWTDTSILG DQREGFSRLSSP*DPAGFYP*PVSLAESLAQIFL I*ANNSQLRNAGHSTQSRQIVIIRK*SNT*AVQ ASSLLKKQFPVEESRA*HCSHFGDHIPCTRSLR EQLHSTGTLLRYGISLQPL*YQVIQAGIPSIREI HFTQFAFMELII*DTKLVFRTNYGKNSSC*EEM RSWKRRD*KQEEAVILSLPKDLNLSTLVVMMGE FPW*HIPNFTREEESTHFTIFEYIS*KSSSLYPE IFH*PHFSTESSRREGWLPKSITLTKPNNRHQQ CCHSVMQKLICEILFL*FLRKSLNGHLC*ITSN *WIAIGIHLF*LCVFTYLFMMATA*STHGCDLIQ KKML*DAVN**QNY*NISG

Sequence NM_000792

GAGCTTACTCTGGCTTTGCCGAGATGGGGCTGCCCCAGCCAGGGCTGTGGCTGAAGAGGCTCTGGGTGCTCTTGGAGGTGGCTGTGCATGTGGTCGTGGG TAAAGTGCTTCTGATATTGTTTCCAGACAGAGTCAAGCGGAACATCCTGGCCATGGGCGAGAAGACGGGTATGACCAGGAACCCCCATTTCAGCCACGAC AACTGGATACCAACCTTTTTCAGCACCCAGTATTTCTGGTTCGTCTTGAAGGTCCGTTGGCAGCGACTAGAGGACACGACTGAGCTAGGGGGTCTGGCCC CAAACTGCCCGGTGGTCCGCCTCTCAGGACAGAGGTGCAACATTTGGGAGTTTATGCAAGGTAATAGGCCACTGGTGCTGAATTTTGGAAGTTGTACCTG ACCTTCATTTATGTTCAAATTTGACCAGTTCAAGAGGCTTATTGAAGACTTTAGTTCCATAGCAGATTTTCTTGTCATTTACATTGAAGAAGCACATGCA TCAGATGGCTGGGCTTTTAAGAACAACATGGACATCAGAAATCACCAGAACCTTCAGGATCGCCTGCAGGCAGCCCATCTACTGCTGGCCAGGAGCCCCC AGTGCCCTGTGGTGGTGGACACCATGCAGAACCAGAGCAGCCAGCTCTACGCAGCACTGCCTGAGAGGCTCTACATAATCCAGGAGGGCAGGATCCTCTA CAAGGGTAAATCTGGCCCTTGGAACTACAACCCAGAGGAAGTTCGTGCTGTTCTGGAAAAGCTCCACAGTTAATCTGGACAGATACCTCAATTCTAGGTG ACCAACGGGAGGGCTTCTCAAGGCTTAGCTCTCCCTGAGACCCAGCTGGCTTTTACCCTTGACCTGTGTCCCTAGCTGAATCACTAGCTCAGATTTTTCT GATCTAAGCAAACAACTCCCAGCTGAGGAATGCAGGCCACAGCACCCAATCAAGACAAATTGTTATTATCAGAAAATGAAGCAACACTTGAGCTGTTCAG GCCAGTTCCCTGTTGAAGAAACAGTTCCCTGTTGAAGAAAGTAGAGCCTGACACTGCTCCCACTTTGGAGACCACATTCCCTGCACACGGTCTTTGAGAG AGCAGTTGCACTCTACAGGCACACTTCTGAGGTACGGTATCTCTCTCCAGCCACTCTGATACCAAGTAATTCAAGCTGGCATTCCTTCTATTAGGGAAAT TCATTTTACCCAATTTGCATTTATGGAATTGATCATTTAAGACACTAAATTAGTTTTTAGAACCAATTATGGGAAGAATTCCAGTTGTTAGGAAGAGATG AGGAGTTGGAAGAGGAGGGATTAGAAACAGGAGGAGGCAGTCATCCTCTCCTTGCCAAAAGATTTAAACCTGTCCACATTGGTGGTGATGATGGGTGAGT TTCCATGGTAACACATCCCTAATTTTACCAGGGAAGAGGAGAGTACTCACTTTACCATCTTTGAATATATTTCATAGAAATCTAGCTCTCTGTACCCTGA AATCTTCCACTAGCCTCACTTTTCAACAGAGTCATCTAGAAGGGAGGGTTGGCTTCCCAAAAGCATAACCTTGACCAAACCAAACAATAGGCACCAGCAA TGCTGTCATTCAGTTATGCAGAAGCTCATTTGTGAAATTCTGTTTCTCTGATTTCTTCGCAAGTCTCTTAATGGTCATTTGTGTTAGATTACATCAAACT GATGGATAGCCATTGGTATTCATCTATTTTAACTCTGTGTCTTTACATATTTGTTTATGATGGCCACAGCCTAAAGTACACACGGCTGTGACTTGATTCA AAAGAAAATGTTATAAGATGCAGTAAACTAATAACAGAATTATTAAAATATATCAGGCTA

refseq_DIO1.F4 (forward primer)
refseq_DIO1.R4 (reverse primer)
Single exon skipping

Frame 0

ELTLALPRWGCPSQGCG*RGSGCSWRWLCMWSW VKCF*YCFQTESSGTSWPWARRRV*PGTPISATT TGYQPFSAPSISGSS*RSVGSD*RTRLS*GVWP QTARWSASQDRGATFGSLCKVIGHWC*ILEVVP DLHLCSNLTSSRGLLKTLVP*QIFLSFTLKKHMH QMAGLLRTTWTSEITRTFRIACRQPIYCWPGAP SALWWWTPCRTRAASSTQHCLRGST*SRRAGSS TRVNLALGTTTQRKFVLFWKSSTVNLDRYLNSR* PTGGLLKA*LSLRPSWLLPLTCVPS*ITSSDFS DLSKQLPAEECRPQHPIKTNCYYQKMKQHLSCS GQFPVEETVPC*RK*SLTLLPLWRPHSLHTVFER AVALYRHTSEVRYLSPATLIPSNSSWHSFY*GN SFYPICIYGIDHLRH*ISF*NQLWEEFQLLGRD EELEEEGLETGGGSHPLLAKRFKPVHIGGDDG*V SMVTHP*FYQGRGEYSLYHL*IYFIEI*LSVP* NLPLASLFNRVI*KGGLASQKHNLDQTKQ*APA MLSFSYAEAHL*NSVSLISSQVS*WSFVLDYIKL MDSHWYSSILTLCLYIFVYDGHSLKYTRL*LDS KENVIRCSKLITELLKYIRL

Frame 1

SLLWLCRDGAAPARAVAEEALGALGGGCACGRG *SASDIVSRQSQAEHPGHGREDGYDQEPPFQPR QLDTNLFQHPVFLVRLEGPLAATRGHD*ARGSGP KLPGGPPLRTEVQHLGVYAR**ATGAEFWKLYL TFIYVQI*PVQEAY*RL*FHSRFSCHLH*RSTC IRWLGF*EQHGHQKSPEPSGSPAGSPSTAGQEPP VPCGGGHHAEPEQPALRSTA*EALHNPGGQDPL QG*IWPLELQPRGSSCCSGKAPQLIWTDTSILG DQREGFSRLSSP*DPAGFYP*PVSLAESLAQIFL I*ANNSQLRNAGHSTQSRQIVIIRK*SNT*AVQ ASSLLKKQFPVEESRA*HCSHFGDHIPCTRSLR EQLHSTGTLLRYGISLQPL*YQVIQAGIPSIREI HFTQFAFMELII*DTKLVFRTNYGKNSSC*EEM RSWKRRD*KQEEAVILSLPKDLNLSTLVVMMGE FPW*HIPNFTREEESTHFTIFEYIS*KSSSLYPE IFH*PHFSTESSRREGWLPKSITLTKPNNRHQQ CCHSVMQKLICEILFL*FLRKSLNGHLC*ITSN *WIAIGIHLF*LCVFTYLFMMATA*STHGCDLIQ KKML*DAVN**QNY*NISG

Frame 2

AYSGFAEMGLPQPGLWLKRLWVLLEVAVHVVVG KVLLILFPDRVKRNILAMGEKTGMTRNPHFSHD NWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLA PNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCT* PSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHA SDGWAFKNNMDIRNHQNLQDRLQAAHLLLARSP QCPVVVDTMQNQSSQLYAALPERLYIIQEGRILY KGKSGPWNYNPEEVRAVLEKLHS*SGQIPQF*V TNGRASQGLALPETQLAFTLDLCP*LNH*LRFF *SKQTTPS*GMQATAPNQDKLLLSENEATLELFR PVPC*RNSSLLKKVEPDTAPTLETTFPAHGL*E SSCTLQAHF*GTVSLSSHSDTK*FKLAFLLLGK FILPNLHLWN*SFKTLN*FLEPIMGRIPVVRKR* GVGRGGIRNRRRQSSSPCQKI*TCPHWW**WVS FHGNTSLILPGKRRVLTLPSLNIFHRNLALCTL KSSTSLTFQQSHLEGRVGFPKA*P*PNQTIGTSN AVIQLCRSSFVKFCFSDFFASLLMVICVRLHQT DG*PLVFIYFNSVSLHICL*WPQPKVHTAVT*F KRKCYKMQ*TNNRIIKIYQA

Sequence NM_213593

GAGCTTACTCTGGCTTTGCCGAGATGGGGCTGCCCCAGCCAGGGCTGTGGCTGAAGAGGCTCTGGGTGCTCTTGGAGGTGGCTGTGCATGTGGTCGTGGG TAAAGTGCTTCTGATATTGTTTCCAGACAGAGTCAAGCGGAACATCCTGGCCATGGGCGAGAAGACGGGTAATAGGCCACTGGTGCTGAATTTTGGAAGT TGTACCTGACCTTCATTTATGTTCAAATTTGACCAGTTCAAGAGGCTTATTGAAGACTTTAGTTCCATAGCAGATTTTCTTGTCATTTACATTGAAGAAG CACATGCATCAGATGGCTGGGCTTTTAAGAACAACATGGACATCAGAAATCACCAGAACCTTCAGGATCGCCTGCAGGCAGCCCATCTACTGCTGGCCAG GAGCCCCCAGTGCCCTGTGGTGGTGGACACCATGCAGAACCAGAGCAGCCAGCTCTACGCAGCACTGCCTGAGAGGCTCTACATAATCCAGGAGGGCAGG ATCCTCTACAAGGGTAAATCTGGCCCTTGGAACTACAACCCAGAGGAAGTTCGTGCTGTTCTGGAAAAGCTCCACAGTTAATCTGGACAGATACCTCAAT TCTAGGTGACCAACGGGAGGGCTTCTCAAGGCTTAGCTCTCCCTGAGACCCAGCTGGCTTTTACCCTTGACCTGTGTCCCTAGCTGAATCACTAGCTCAG ATTTTTCTGATCTAAGCAAACAACTCCCAGCTGAGGAATGCAGGCCACAGCACCCAATCAAGACAAATTGTTATTATCAGAAAATGAAGCAACACTTGAG CTGTTCAGGCCAGTTCCCTGTTGAAGAAACAGTTCCCTGTTGAAGAAAGTAGAGCCTGACACTGCTCCCACTTTGGAGACCACATTCCCTGCACACGGTC TTTGAGAGAGCAGTTGCACTCTACAGGCACACTTCTGAGGTACGGTATCTCTCTCCAGCCACTCTGATACCAAGTAATTCAAGCTGGCATTCCTTCTATT AGGGAAATTCATTTTACCCAATTTGCATTTATGGAATTGATCATTTAAGACACTAAATTAGTTTTTAGAACCAATTATGGGAAGAATTCCAGTTGTTAGG AAGAGATGAGGAGTTGGAAGAGGAGGGATTAGAAACAGGAGGAGGCAGTCATCCTCTCCTTGCCAAAAGATTTAAACCTGTCCACATTGGTGGTGATGAT GGGTGAGTTTCCATGGTAACACATCCCTAATTTTACCAGGGAAGAGGAGAGTACTCACTTTACCATCTTTGAATATATTTCATAGAAATCTAGCTCTCTG TACCCTGAAATCTTCCACTAGCCTCACTTTTCAACAGAGTCATCTAGAAGGGAGGGTTGGCTTCCCAAAAGCATAACCTTGACCAAACCAAACAATAGGC ACCAGCAATGCTGTCATTCAGTTATGCAGAAGCTCATTTGTGAAATTCTGTTTCTCTGATTTCTTCGCAAGTCTCTTAATGGTCATTTGTGTTAGATTAC ATCAAACTGATGGATAGCCATTGGTATTCATCTATTTTAACTCTGTGTCTTTACATATTTGTTTATGATGGCCACAGCCTAAAGTACACACGGCTGTGAC TTGATTCAAAAGAAAATGTTATAAGATGCAGTAAACTAATAACAGAATTATTAAAATATATCAGGCTA

refseq_DIO1.F4 (forward primer)
refseq_DIO1.R4 (reverse primer)
Single exon skipping

Frame 0

ELTLALPRWGCPSQGCG*RGSGCSWRWLCMWSW VKCF*YCFQTESSGTSWPWARRRVIGHWC*ILEV VPDLHLCSNLTSSRGLLKTLVP*QIFLSFTLKK HMHQMAGLLRTTWTSEITRTFRIACRQPIYCWP GAPSALWWWTPCRTRAASSTQHCLRGST*SRRAG SSTRVNLALGTTTQRKFVLFWKSSTVNLDRYLN SR*PTGGLLKA*LSLRPSWLLPLTCVPS*ITSS DFSDLSKQLPAEECRPQHPIKTNCYYQKMKQHLS CSGQFPVEETVPC*RK*SLTLLPLWRPHSLHTV FERAVALYRHTSEVRYLSPATLIPSNSSWHSFY *GNSFYPICIYGIDHLRH*ISF*NQLWEEFQLLG RDEELEEEGLETGGGSHPLLAKRFKPVHIGGDD G*VSMVTHP*FYQGRGEYSLYHL*IYFIEI*LS VP*NLPLASLFNRVI*KGGLASQKHNLDQTKQ*A PAMLSFSYAEAHL*NSVSLISSQVS*WSFVLDY IKLMDSHWYSSILTLCLYIFVYDGHSLKYTRL* LDSKENVIRCSKLITELLKYIRL

Frame 1

SLLWLCRDGAAPARAVAEEALGALGGGCACGRG *SASDIVSRQSQAEHPGHGREDG**ATGAEFWK LYLTFIYVQI*PVQEAY*RL*FHSRFSCHLH*RS TCIRWLGF*EQHGHQKSPEPSGSPAGSPSTAGQ EPPVPCGGGHHAEPEQPALRSTA*EALHNPGGQ DPLQG*IWPLELQPRGSSCCSGKAPQLIWTDTSI LGDQREGFSRLSSP*DPAGFYP*PVSLAESLAQ IFLI*ANNSQLRNAGHSTQSRQIVIIRK*SNT* AVQASSLLKKQFPVEESRA*HCSHFGDHIPCTRS LREQLHSTGTLLRYGISLQPL*YQVIQAGIPSI REIHFTQFAFMELII*DTKLVFRTNYGKNSSC* EEMRSWKRRD*KQEEAVILSLPKDLNLSTLVVMM GEFPW*HIPNFTREEESTHFTIFEYIS*KSSSL YPEIFH*PHFSTESSRREGWLPKSITLTKPNNR HQQCCHSVMQKLICEILFL*FLRKSLNGHLC*IT SN*WIAIGIHLF*LCVFTYLFMMATA*STHGCD LIQKKML*DAVN**QNY*NISG

Frame 2

AYSGFAEMGLPQPGLWLKRLWVLLEVAVHVVVG KVLLILFPDRVKRNILAMGEKTGNRPLVLNFGS CT*PSFMFKFDQFKRLIEDFSSIADFLVIYIEE AHASDGWAFKNNMDIRNHQNLQDRLQAAHLLLAR SPQCPVVVDTMQNQSSQLYAALPERLYIIQEGR ILYKGKSGPWNYNPEEVRAVLEKLHS*SGQIPQ F*VTNGRASQGLALPETQLAFTLDLCP*LNH*LR FF*SKQTTPS*GMQATAPNQDKLLLSENEATLE LFRPVPC*RNSSLLKKVEPDTAPTLETTFPAHG L*ESSCTLQAHF*GTVSLSSHSDTK*FKLAFLLL GKFILPNLHLWN*SFKTLN*FLEPIMGRIPVVR KR*GVGRGGIRNRRRQSSSPCQKI*TCPHWW** WVSFHGNTSLILPGKRRVLTLPSLNIFHRNLALC TLKSSTSLTFQQSHLEGRVGFPKA*P*PNQTIG TSNAVIQLCRSSFVKFCFSDFFASLLMVICVRL HQTDG*PLVFIYFNSVSLHICL*WPQPKVHTAVT *FKRKCYKMQ*TNNRIIKIYQA