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Sequences

Sequence NM_018313

AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAAGTTGGATTCC
ATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCAGGA
AAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAGACT
TCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAA
CTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAAT
ATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCA
AGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCA
GGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTG
CCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC
TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATGAGG
ACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCACTAGCAAGTATTACCGTAATA
AAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCACGCTATGA
AGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAA
GGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCC
GAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTC
AGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATC
TCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTC
GAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA
CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAGGCACTAT
AATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGATGATGACA
TGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGGTCTATGA
AGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATT
AAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATA
ATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGA
GGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTAC
AGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCT
ACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA
ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTTGCATAAT
GATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGTGAAGATT
CCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCTATGTGGA
ACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAA
GTTCCAGTTAGTAAAATTCTAGGCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCT
GTGAATCACGGTATTCTGCCAAAACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCT
GCCTGTGGTTCGCGTGGCCTCTGTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTT
AACTTGGAAAAGGAAAAAGAAGATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGA
AGGTTGGCGACTGTGTCTTCATCAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTA
TGGCCCCATCTTCATTCACCCAGAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCC
ATGACATGTATTCTCGGAAAGTGTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGA
GCCGCTACAATGAGAGCGACAAGCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAG
AAAACCAATTGTTCCTCAGAAGGAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGAT
ATTGAAGAGATGGGAGAAGAAGATAGTGAGTCTACCCCAAAGTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCT
ACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAAGGCCCAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAA
TCTTGAGACAGCCAAGAAAGCAGAATATGAAGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATG
GGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACC
AAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCC
ATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCA
GAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGT
CGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCT
CCGGGACACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGT
AGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTT
TTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTCATA
ATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCT
TGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGT
GAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTAC
AGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATAT
GTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGT
TAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAAT
GAATTCACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTAT
GCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAA
GTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAATTCT
CAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACTAGA
AAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTA
GGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAG
AGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGT
GTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAA
GTATTTTAAATAATATTGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTT
GGGCAATTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAA
ATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGG
GTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGCAGC
ACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGGGGG
ATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTT
TCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCA
AACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTA
AGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATA
CCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTC
ATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTGCAAAGTGA
  • refseq_PB1.F5 (forward primer)
  • refseq_PB1.R5 (reverse primer)
  • Alternative donor

Frame 0

RSNSSSRGGHGAGRGGR*PRPGLQAAERLEVGF
HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQE
KEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQT
SL*ALH*GTKAKKSTRLL*SGFSAH*LDENPTE
TKNGRV**C*FADC*LPASF*QCKVLL*ARFS*I
*SRLQTLGFVPSNKK*VCSERRSR*RR***RWA
RQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKSI
RTSH*RTFSETAF*SAISRLLCNN*GAYRSQDHC
PEDTEWKLQKYSCNGQRYRSPRKKCQNL**AWL
SSIQGCKFN*KNILYEKG*N*TS*NG*VKSSNE
DSIQLGCSQTDRSFTQ*RQPW*REKSH*QVLP**
KSSTRRSFISNYNGTSIWLRK*RRCCFSCCTL*
RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE*P
RAANS*TFLPFAFKEKIP*LLPAN*NAHITTTDP
NKTEESRI*NFRSFGV*SEFNV*KCQTL*CAQF
SHLQASSKIAASYAGKEERACQERRYRGRRQHD
LFSHL*YW*CQKKK*KEHKKAANENLIQCCS*SS
RARFRQKTL*PIYG*TIQKGLS*LL*NHLGANG
LENN*A*HPQ*QICW*RGNDRRHEADVPECQAL
**GGLPGL**CTYPGEVTQGEKERAGPTA****H
GFSQTQAE*EEWHFS*KIKIHDSNAAETK*GL*
SCKELY**EGSPPQCHISEASL*I*VA*LLSDY
*KAHGHGKNSKSHDGQQVPRY*LYG*GLCHDV**
CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGGR*
GLSCPKCDFADSRAYPQSFCVSHESSG**GKML
QRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K*SL
PSA*FISRAYV*SIGTSKKDESDRFRNI*RCSR
TSAVFY*NS**TLQKWRDSSFTGTQLYHKTFA*
*CGEREKGKIAKRNRGR*TKTRRRKKRS*KE*RF
LWCCRPLRLTSHIQPGL*L*KQHVPCWRLRLCG
TCRGQPTTTYRLY*KTVGGFS*KRSF*E*LLQQ
SSS**NSRQVCGHVCQGIL*VMPRKLPR*GCFCL
*ITVFCQNQIF*EN*TVDHAHQLSQVCPSGCAS
ACGSRGLCICKCR*R***EEYRQLRGQSS*RQF
*LGKGKRRCPCGNVQW*TRLPLL*AAPLQ*HVAE
GWRLCLHQVPWPGASSCGQN*KSMGSRWSCIFL
WPHLHSPRRNRA*AHKNVLQKRSISE*SGRNLP
HDMYSRKVCCVVIQGLPLLQAN*NTRK*HSAL*E
PLQ*ERQADEEIQRIEEVFTLC*SGR**NLLLQ
KTNCSSEGAITFAGKEDPVARS*ICRVRRWR**
Y*RDGRRR**VYPKVCQRQCKEGRLQTENQHEWL
HPVQQ*DEGCD*GPTPRLLFRGAQPPGGDRMEK
S*DSQESRI*RHDGWLSARPSTFAGPS*WPC*H
GQHAATSPWGASTPPSSARCAWPPGHPTTGCDEP
RSGPYGRDSSTRWKSIWTTGGSFGASRAAGTTS
ISRPTSSWTPCHTAANNTHVCSSPTKDPAASSL
RGLPEIH*RTQCGVQQH*QVGSDTGSSKTRRPFV
ERTGEPPTLSLAEKQRGPHHHGRCPLAPSRFDA
PGHPQHSPSIQPRKCLITSLRFFYIEA*RVVDQ
*PF*LLGVGGRNKGG*FLLHFTVHHKAIFIYGHF
**AISICLLY*VDFIKYTKIFLHMFPSFKTSFI
IGCICRLGVLSFYLLPWN*NH*RFLSWLGVFVF
LVLGFFIYIYKRTK*KKTHTHKSLQISLN***NV
KFVLVYILERGVYLCLFHVPEYLKPLSAKAVSY
R*SAFFERWLFRF*MFNRHSTFALLTQRLTTEI
CNQCCASVCS*CTSWTPGGEKALFQLC*VRHL*V
RLWCQ*FLQNTCTTLRYV*SRQVRLRIF*SIYN
EFTIYAYKFQMI*NFKPVTLKNIEVRLEESIKV
CMEVIYF*T*HLT*HG*ESMELDMSCIRSIIVNK
*IDCLHIQVCFSIPYFLIIRCIFSFKFQCCYNS
QPEI*YFLKYFLNLACAFELQEKGIII**NAY*
KDHYRSQTLGFGDPVFLI*PYNKHLKAA*DGRQ*
EHCFTWRHVFETCFIVTG*LPLW*SFHCCL*SE
RVNLRGCFFPFNLL*ISTQMFNYCTY*IMRAKE
CRMEKSLLYLDTLNMGGPLT*LPLVNHWI*ICIK
YFK*Y*I*KNVLQ*CVSTLLLK*VR*IFNSWLF
GQLNHHGLYNAIRLFCF*TSLNYTKEHEI*LWL
NYLFISCIHFISLKVWMRLLWGASKKIFHWGPRG
SLEARALLQAPSQCLEVL*ET*IQPGASLKQCS
TGPGHH*TGPN*VFFKKPVYLF*NHVFLYINLG
DIVNI*DIRFEVSHLQKRKKN*LKKVQVNYTPFF
HKF*EL**CGLESIMA*MFSKCKFLWRRIVYIA
NGGTEGNL*V*NSMFVSQLI*KAFNCFGCCFFF
KPLSPSYEEELRGAPISVKSPNWC**F*A*MFSY
LIKTWFILISVSYHLRFTW*LVL*HVCIFFLLF
I*SFLIQINTEFAK*

Frame 1

GAIAAAVAATGRGAAVGDRGRGCRRRSGWKLDS
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSR
KRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRL
LCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQK
LKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPE
YKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQ
DNQGTVTEGSSPAYLKEILEQLLEAIVVATNPS
GRLISELFQKLPSKVQYPDYYAIIKEPIDLKTI
AQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGS
QVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMR
TPSNLAAARLTGPSHSKGSLGEERNPTSKYYRN
KRAVQGGRLSAITMALQYGSESEEDAALAAARYE
EGESEAESITSFMDVSNPFYQLYDTVRSCRNNQ
GQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQI
RTKLKNQEYETLDHLECDLNLMFENAKRYNVPNS
AIYKRVLKLQQVMQAKKKELARRDDIEDGDSMI
SSATSDTGSAKRKSKKNIRKQRMKILFNVVLEA
REPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMD
LKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHY
NEEGSQVYNDAHILEKLLKEKRKELGPLPDDDD
MASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYE
AVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTI
KKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFN
NACTYNEPESLIYKDALVLHKVLLETRRDLEGDE
DSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCY
SDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNR
YRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVE
LQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSED
SSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVE
PAEANLQPHIVCIERLWEDSAEKEVFKSDYYNK
VPVSKILGKCVVMFVKEYFKLCPENFRDEDVFV
CESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPL
PVVRVASVFANADKGDDEKNTDNSEDSRAEDNF
NLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWL
KVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFY
GPIFIHPEETEHEPTKMFYKKEVFLSNLEETCP
MTCILGKCAVLSFKDFLSCRPTEIPENDILLCE
SRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDD
IEEMGEEDSESTPKSAKGSAKKEGSKRKINMSG
YILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRN
LETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSM
GSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMN
QGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPP
YPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHS
EAYLKYIEGLSAESNSISKWDQTLAARRRDVHL
SKEQESRLPSHWLKSKGAHTTMADALWRLRDLML
RDTLNIRQAYNLENV*SHHYVSFI*KHKELWIS
SHFSYWGWGEGTKEDNFYCILLYITRPFLYTDT
FNKLFQFVCYIKLTLSNTQRFFCICFLRLKPVS*
LVVYVDLEFYLFTCCHGTETIRGFCLGLGFLFS
WFWVFLYIYIKEQNEKKHTHTRVYRLV*IDNEM
*SLS*FTS*RGEYTCVCFMCLNILSHFLQKLFLT
DEVLSLKGGYLGFRCLIDTAHLLY*LRGSLQKY
VISAVHLSAANVPPGHQEGKKHFFNCAELDICE
LDYGVSDFCRTRAQP*GMFNLGRYV*GYFDLFIM
NSQFMPINFR*FKILNLLH*KTLKFVLKKALRY
AWR*FIFKHNT*PNMGKRVWN*I*AV*EA*L*T
SRLIAFIYKYVLVFLISLLSDVFFLLSFNVVIIL
NQKFNTF*NIF*I*LVLLNYRRRES*FNKTLTR
KTITDPKHLGLVTLSFLYDPTINI*RQHRMADS
RNIVSLGGMFLKPAL**LGDCHCGRASTAVYNLR
ELISEDAFFLLICYESVPRCLITVLIKS*GQKS
VEWKKVSCI*IL*IWEAL*LNCL*STTGFEFAS
SILNNIEFKKMYCSSVSVPYC*SESDKSSIPGYL
GN*IIMDCIMQSDYFVSRHP*ITPKNMKFSCG*
IIYLFHAFILFPLRSG*DFFGEPLKKFFTGGHV
GH*KPELSSRLLPSA*RCYRKHRSSQGLP*SSAA
PAQGITRQALIKFFLKSLCIYFRIMFFCILTWG
ISLIFRI*DLRSAIFKKEKKIDSRKYK*TIHLF
FISFRNCSNVA*KV*WPKCFQNVSSCGEELFILQ
TGGLRGTCRFKTVCLSAN*FKRPLTVLVVVFFL
SHSPLPMRKN*EGHLFL*NPQIGVDDFELECFH
T*LKLGLF*FLYHII*GLRGN*SYNMYVSFFCCS
SKAF*SK*IQSLQS

Frame 2

EQ*QQPWRPRGGARRSVTAAGAAGGGAAGSWIP
WVPREEELPPLPAVSAGTLMMGTILCQHQAQAG
KGGDFPIFQL*ILLPCAMNSIIPSETIRMNRAD
FSVSSSLGHQSEEINQTIMKWFLSPLT**KSNRN
*KWKSMMMLIC*LLTSSFFLTMQSPIISQILLN
IKPLANSGICTFEQEMSLFRKEKQMTKMMMKMG
KTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIHQ
DVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRPL
PRGYRMEATKVFMQWPKI*ISSQKMPKLIMSLA
LKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE*G
LHPTWLQPD*QVLHTVKAALVKREIPLASITVI
KEQYKEVVYQQLQWHFNMAQKVKKMLL*LLHAM
KRESQKQKASLPLWMFQILFISFMTQLGVVGITK
GS**LNLFTICLQRKNTLIITSKLKCPYHYNRS
EQN*RIKNMKL*IIWSVI*I*CLKMPNAIMCPI
QPSTSEF*NCSKLCRQRRKSLPGETISRTETA*S
LQPPLILVVPKEKVKRT*ESSE*KSYSMLFLKL
ESQVQAEDFVTYLWLNHPKRTILIIIKSSWSQW
T*K*LSITSAMTNMLVKRE**KT*S*CSGMPGTI
MRRAPRFIMMHISWRSYSRRKGKSWAHCLMMMT
WLLPNSS*VGRVAFLLKNQNT*LQCSRN*MRSM
KL*RTILIRGVAASVPYF*GFPLDLSCLTTI*LL
KSPWTWKKFEVT*WPTSTKILTLWLRTLS*CLI
MPVHTMSRSL*STKMLLFYTKSCLKHAETWREM
RTLMSQM*LC*FKSLSTIFLCQS*VIRMMREDAT
AIL*QKFLLWIPTFLTNHPLHLT*LGRMLKIIA
TVGLIYFKSICLKYWNEQEG*IGQIQKYMKMQ*
NFSSFLLKFVMNSAKMERFFFHRHSAIPQNICIM
MWRKRERKNCQKK*RKIN*NEKKKKEKLKRVKI
PLVLQASQAYIAHTARTVALKTACTMLEITSMW
NLQRPTYNHISSVLKDCGRIQLKKKFLRVTITTK
FQLVKF*ASVWSCLSRNTLSYAQKTSEMRMFLS
VNHGILPKPNLLRKLNCGPCPSAQSGLSLGMCL
CLWFAWPLYLQMQIKVMMRRIQTTQRTVELKTIL
TWKRKKKMSLWKCPMVNQVATTLSSSITMTCG*
RLATVSSSSPMAWCVLVWAELKKYGFEMELHIF
MAPSSFTQKKQSMSPQKCSTKKKYF*VIWKKPAP
*HVFSESVLCCHSRTSSPAGQLKYQKMTFCFVR
AATMRATSR*RNSKD*RGFHSLLKW*MMKFTTS
ENQLFLRRSHHLCWKRRSSC*KLNLPS*KVEMMI
LKRWEKKIVSLPQSLPKAVQRRKAPNGKST*VA
TSCSAVR*GL*LRPNTQTTLSGSSAAWWGQNGE
ILRQPRKQNMKA*WVAIRQAFHLCRAQLMALLAW
AACSHFTLGGLHPTIFRQVCLASRASHHRV**T
KEWPLW*GLQHQVEVHMDNRWEFWGLQGSRHHL
HIPAHIQLDPLSYSSQQHPCL*LPHQRPSGFFTQ
RPT*NTLKDSVRSPTALASGIRHWQLEDATSIC
RKNRRAAYPLTG*KAKGPTPPWQMPSGAFEI*C
SGTPSTFAKHTT*KMFNHIITFLLYRSIKSCGSV
AILVTGGGGKEQRRIIFIAFYCTSQGHFYIRTL
LISYFNLFVILS*LYQIHKDFFAYVSFV*NQFH
NWLYM*TWSFIFLLVAMELKPLEVFVLAWGFCFL
GFGFFYIYI*KNKMKKNTHTQEFTD*FKLIMKC
EVCPSLHLREGSILVFVSCA*IS*ATFCKSCFL
QMKCFL*KVVI*VLDV**TQHICSINSEAHYRNM
*SVLCICLQLMYLLDTRRGKSTFSIVLS*TSVS
*TMVSVIFAEHVHNPEVCLI*AGTFKDILIYL*
*IHNLCL*ISDDLKF*TCYIEKH*SSS*RKH*GM
HGGDLFLNITPNLTWVREYGTRYELYKKHNCEQ
VD*LPSYTSMF*YSLFPYYQMYFFF*VSMLL*F
STRNLILSKIFFKFSLCF*ITGEGNHNLIKRLLE
RPLQIPNTWVW*PCLSYMTLQ*TFEGSIGWQTV
GTLFHLAACF*NLLYSNWVIAIVVELPLLFII*
ES*SQRMLFSF*SAMNQYPDV*LLYLLNHEGKRV
*NGKKSLVSRYFKYGRPFNLIAFSQPLDLNLHQ
VF*IILNLKKCIAVVCQYLIVKVSQINLQFLAI
WAIESSWTV*CNQIILFLDILELHQRT*NLVVVK
LFIYFMHSFYFP*GLDETSLGSL*KNFSLGATW
VIRSQSSPPGSFPVPRGAIGNIDPARGFPKAVQ
HRPRASLDRP*LSFF*KACVFILESCFSVY*LGG
YR*YLGYKI*GQPSSKKKKKLTQESTSKLYTFF
S*VLGTVVMWLRKYNGLNVFKM*VPVEKNCLYC
KRGD*GEPVGLKQYVCQPTDLKGL*LFWLLFFF*
ATLPFL*GRIERGTYFCKIPKLVLMILSLNVFI
PD*NLVYSNFCIISSEVYVVTSLITCMYLFFVV
HLKLFNPNKYRVCKV

Sequence NM_018165

TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCA
GGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAG
ACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAG
AAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTG
AATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGG
GCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCA
TCAGGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCA
TTGCCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGG
CTCTCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATG
AGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCAC
GCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAA
TAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAA
CAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGC
CCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAG
CATGATCTCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTT
GAAGCTCGAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGC
CAATGGACTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAG
GCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGAT
GATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGG
TCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCT
GACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATG
TTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGG
GAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAG
ATGCTACAGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAAT
AATCGCTACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATG
CAGTAGAACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTT
GCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGT
GAAGATTCCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCT
ATGTGGAACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGGTGAAAAATGGTTGTATGGCTGTTGGTT
TTACCGACCAAATGAAACATTCCACCTGGCTACACGAAAATTTCTAGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAAGTTCCAGTTAGTAAAATT
CTAGGCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCTGTGAATCACGGTATTCTG
CCAAAACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCTGCCTGTGGTTCGCGTGGC
CTCTGTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTTAACTTGGAAAAGGAAAAA
GAAGATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGAAGGTTGGCGACTGTGTCT
TCATCAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTATGGCCCCATCTTCATTCA
CCCAGAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCCATGACATGTATTCTCGGA
AAGTGTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGAGCCGCTACAATGAGAGCG
ACAA
GCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAGAAAACCAATTGTTCCTCA
GAAGGAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGATATTGAAGAGATGGGAGAA
GAAGATAGTGAGGTCATTGAACCTCCTTCTCTACCTCAGCTTCAGACCCCCCTGGCCAGTGAGCTGGACCTCATGCCCTACACACCCCCACAGTCTACCC
CAAAGTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCTACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAA
GGCCCAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGGCATG
ATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCAC
CCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGG
TGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATA
CAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGG
AGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCT
GAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCGCCAAGCATACAACCTA
GAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAA
AGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTT
GACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTT
ACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAAC
AAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTA
TACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGT
TTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTAC
CTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGC
ACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTCACAATTTATGCCTATAAATTTCAGATGATTT
AAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTATGCATGGAGGTGATTTATTTTTAAACATAACACCTAAC
CTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGT
ATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAA
ATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGA
CCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACC
TGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATC
TGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTT
AAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATATTGAATTTAAAAAAATGTATTG
CAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAATTGAATCATCATGGACTGTATAATGCAATCA
GATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCT
TAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCC
CAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAG
TTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAG
CCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAA
AGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACA
GTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGG
GGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCA
TATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTG
CAAAGTGA
  • refseq_PB1.F5 (forward primer)
  • refseq_PB1.R5 (reverse primer)
  • Alternative donor

Frame 0

SMGSKRRRATSPSSSVSGDFDDGHHSVSTPGPS
RKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGR
LLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQ
KLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSP
EYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDG
QDNQGTVTEGSSPAYLKEILEQLLEAIVVATNP
SGRLISELFQKLPSKVQYPDYYAIIKEPIDLKT
IAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPG
SQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRM
SNKRAVQGGRLSAITMALQYGSESEEDAALAAA
RYEEGESEAESITSFMDVSNPFYQLYDTVRSCRN
NQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQ
QIRTKLKNQEYETLDHLECDLNLMFENAKRYNV
PNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDS
MISSATSDTGSAKRKSKKNIRKQRMKILFNVVL
EAREPGSGRRLCDLFMVKPSKKDYPDYYKIILE
PMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNAR
HYNEEGSQVYNDAHILEKLLKEKRKELGPLPDD
DDMASPKLKLSRKSGISPKKSKYMTPMQQKLNE
VYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYL
TIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMM
FNNACTYNEPESLIYKDALVLHKVLLETRRDLE
GDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGR
CYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVEN
NRYRRLDLFQEHMFEVLERARRMNRTDSEIYED
AVELQQFFIKIRDELCKNGEILLSPALSYTTKHL
HNDVEKERKEKLPKEIEEDKLKREEEKREAEKS
EDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYV
YVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWF
YRPNETFHLATRKFLEKEVFKSDYYNKVPVSKI
LGKCVVMFVKEYFKLCPENFRDEDVFVCESRYS
AKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVA
SVFANADKGDDEKNTDNSEDSRAEDNFNLEKEK
EDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCV
FIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIH
PEETEHEPTKMFYKKEVFLSNLEETCPMTCILG
KCAVLSFKDFLSCRPTEIPENDILLCESRYNES
DK
QMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQ
KEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGE
EDSEVIEPPSLPQLQTPLASELDLMPYTPPQST
PKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIK
AQHPDYSFGELSRLVGTEWRNLETAKKAEYEGM
MGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPP
PHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPG
GSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVI
QQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSA
ESNSISKWDQTLAARRRDVHLSKEQESRLPSHWL
KSKGAHTTMADALWRLRDLMLRDTLNIRQAYNL
ENV*SHHYVSFI*KHKELWISSHFSYWGWGEGT
KEDNFYCILLYITRPFLYTDTFNKLFQFVCYIKL
TLSNTQRFFCICFLRLKPVS*LVVYVDLEFYLF
TCCHGTETIRGFCLGLGFLFSWFWVFLYIYIKE
QNEKKHTHTRVYRLV*IDNEM*SLS*FTS*RGEY
TCVCFMCLNILSHFLQKLFLTDEVLSLKGGYLG
FRCLIDTAHLLY*LRGSLQKYVISAVHLSAANV
PPGHQEGKKHFFNCAELDICELDYGVSDFCRTRA
QP*GMFNLGRYV*GYFDLFIMNSQFMPINFR*F
KILNLLH*KTLKFVLKKALRYAWR*FIFKHNT*
PNMGKRVWN*I*AV*EA*L*TSRLIAFIYKYVLV
FLISLLSDVFFLLSFNVVIILNQKFNTF*NIF*
I*LVLLNYRRRES*FNKTLTRKTITDPKHLGLV
TLSFLYDPTINI*RQHRMADSRNIVSLGGMFLKP
AL**LGDCHCGRASTAVYNLRELISEDAFFLLI
CYESVPRCLITVLIKS*GQKSVEWKKVSCI*IL
*IWEAL*LNCL*STTGFEFASSILNNIEFKKMYC
SSVSVPYC*SESDKSSIPGYLGN*IIMDCIMQS
DYFVSRHP*ITPKNMKFSCG*IIYLFHAFILFP
LRSG*DFFGEPLKKFFTGGHVGH*KPELSSRLLP
SA*RCYRKHRSSQGLP*SSAAPAQGITRQALIK
FFLKSLCIYFRIMFFCILTWGISLIFRI*DLRS
AIFKKEKKIDSRKYK*TIHLFFISFRNCSNVA*K
V*WPKCFQNVSSCGEELFILQTGGLRGTCRFKT
VCLSAN*FKRPLTVLVVVFFLSHSPLPMRKN*E
GHLFL*NPQIGVDDFELECFHT*LKLGLF*FLYH
II*GLRGN*SYNMYVSFFCCSSKAF*SK*IQSL
QS

Frame 1

PWVPREEELPPLPAVSAGTLMMGTILCQHQAQA
GKGGDFPIFQL*ILLPCAMNSIIPSETIRMNRA
DFSVSSSLGHQSEEINQTIMKWFLSPLT**KSNR
N*KWKSMMMLIC*LLTSSFFLTMQSPIISQILL
NIKPLANSGICTFEQEMSLFRKEKQMTKMMMKM
GKTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIH
QDVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRP
LPRGYRMEATKVFMQWPKI*ISSQKMPKLIMSL
ALKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE*
VIKEQYKEVVYQQLQWHFNMAQKVKKMLL*LLH
AMKRESQKQKASLPLWMFQILFISFMTQLGVVG
ITKGS**LNLFTICLQRKNTLIITSKLKCPYHYN
RSEQN*RIKNMKL*IIWSVI*I*CLKMPNAIMC
PIQPSTSEF*NCSKLCRQRRKSLPGETISRTET
A*SLQPPLILVVPKEKVKRT*ESSE*KSYSMLFL
KLESQVQAEDFVTYLWLNHPKRTILIIIKSSWS
QWT*K*LSITSAMTNMLVKRE**KT*S*CSGMP
GTIMRRAPRFIMMHISWRSYSRRKGKSWAHCLMM
MTWLLPNSS*VGRVAFLLKNQNT*LQCSRN*MR
SMKL*RTILIRGVAASVPYF*GFPLDLSCLTTI
*LLKSPWTWKKFEVT*WPTSTKILTLWLRTLS*C
LIMPVHTMSRSL*STKMLLFYTKSCLKHAETWR
EMRTLMSQM*LC*FKSLSTIFLCQS*VIRMMRE
DATAIL*QKFLLWIPTFLTNHPLHLT*LGRMLKI
IATVGLIYFKSICLKYWNEQEG*IGQIQKYMKM
Q*NFSSFLLKFVMNSAKMERFFFHRHSAIPQNI
CIMMWRKRERKNCQKK*RKIN*NEKKKKEKLKRV
KIPLVLQASQAYIAHTARTVALKTACTMLEITS
MWNLQRPTYNHISSVLKDCGRIQLVKNGCMAVG
FTDQMKHSTWLHENF*KKKFLRVTITTKFQLVKF
*ASVWSCLSRNTLSYAQKTSEMRMFLSVNHGIL
PKPNLLRKLNCGPCPSAQSGLSLGMCLCLWFAW
PLYLQMQIKVMMRRIQTTQRTVELKTILTWKRKK
KMSLWKCPMVNQVATTLSSSITMTCG*RLATVS
SSSPMAWCVLVWAELKKYGFEMELHIFMAPSSF
TQKKQSMSPQKCSTKKKYF*VIWKKPAP*HVFSE
SVLCCHSRTSSPAGQLKYQKMTFCFVRAATMRA
T
SR*RNSKD*RGFHSLLKW*MMKFTTSENQLFL
RRSHHLCWKRRSSC*KLNLPS*KVEMMILKRWEK
KIVRSLNLLLYLSFRPPWPVSWTSCPTHPHSLP
QSLPKAVQRRKAPNGKST*VATSCSAVR*GL*L
RPNTQTTLSGSSAAWWGQNGEILRQPRKQNMKA*
WVAIRQAFHLCRAQLMALLAWAACSHFTLGGLH
PTIFRQVCLASRASHHRV**TKEWPLW*GLQHQ
VEVHMDNRWEFWGLQGSRHHLHIPAHIQLDPLSY
SSQQHPCL*LPHQRPSGFFTQRPT*NTLKDSVR
SPTALASGIRHWQLEDATSICRKNRRAAYPLTG
*KAKGPTPPWQMPSGAFEI*CSGTPSTFAKHTT*
KMFNHIITFLLYRSIKSCGSVAILVTGGGGKEQ
RRIIFIAFYCTSQGHFYIRTLLISYFNLFVILS
*LYQIHKDFFAYVSFV*NQFHNWLYM*TWSFIFL
LVAMELKPLEVFVLAWGFCFLGFGFFYIYI*KN
KMKKNTHTQEFTD*FKLIMKCEVCPSLHLREGS
ILVFVSCA*IS*ATFCKSCFLQMKCFL*KVVI*V
LDV**TQHICSINSEAHYRNM*SVLCICLQLMY
LLDTRRGKSTFSIVLS*TSVS*TMVSVIFAEHV
HNPEVCLI*AGTFKDILIYL**IHNLCL*ISDDL
KF*TCYIEKH*SSS*RKH*GMHGGDLFLNITPN
LTWVREYGTRYELYKKHNCEQVD*LPSYTSMF*
YSLFPYYQMYFFF*VSMLL*FSTRNLILSKIFFK
FSLCF*ITGEGNHNLIKRLLERPLQIPNTWVW*
PCLSYMTLQ*TFEGSIGWQTVGTLFHLAACF*N
LLYSNWVIAIVVELPLLFII*ES*SQRMLFSF*S
AMNQYPDV*LLYLLNHEGKRV*NGKKSLVSRYF
KYGRPFNLIAFSQPLDLNLHQVF*IILNLKKCI
AVVCQYLIVKVSQINLQFLAIWAIESSWTV*CNQ
IILFLDILELHQRT*NLVVVKLFIYFMHSFYFP
*GLDETSLGSL*KNFSLGATWVIRSQSSPPGSF
PVPRGAIGNIDPARGFPKAVQHRPRASLDRP*LS
FF*KACVFILESCFSVY*LGGYR*YLGYKI*GQ
PSSKKKKKLTQESTSKLYTFFS*VLGTVVMWLR
KYNGLNVFKM*VPVEKNCLYCKRGD*GEPVGLKQ
YVCQPTDLKGL*LFWLLFFF*ATLPFL*GRIER
GTYFCKIPKLVLMILSLNVFIPD*NLVYSNFCI
ISSEVYVVTSLITCMYLFFVVHLKLFNPNKYRVC
KV

Frame 2

HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQ
EKEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQ
TSL*ALH*GTKAKKSTRLL*SGFSAH*LDENPT
ETKNGRV**C*FADC*LPASF*QCKVLL*ARFS*
I*SRLQTLGFVPSNKK*VCSERRSR*RR***RW
ARQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKS
IRTSH*RTFSETAF*SAISRLLCNN*GAYRSQDH
CPEDTEWKLQKYSCNGQRYRSPRKKCQNL**AW
LSSIQGCKFN*KNILYEKG*N*TS*NG*VKSSN
E**KSSTRRSFISNYNGTSIWLRK*RRCCFSCCT
L*RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE
*PRAANS*TFLPFAFKEKIP*LLPAN*NAHITT
TDPNKTEESRI*NFRSFGV*SEFNV*KCQTL*CA
QFSHLQASSKIAASYAGKEERACQERRYRGRRQ
HDLFSHL*YW*CQKKK*KEHKKAANENLIQCCS
*SSRARFRQKTL*PIYG*TIQKGLS*LL*NHLGA
NGLENN*A*HPQ*QICW*RGNDRRHEADVPECQ
AL**GGLPGL**CTYPGEVTQGEKERAGPTA**
**HGFSQTQAE*EEWHFS*KIKIHDSNAAETK*G
L*SCKELY**EGSPPQCHISEASL*I*VA*LLS
DY*KAHGHGKNSKSHDGQQVPRY*LYG*GLCHD
V**CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGG
R*GLSCPKCDFADSRAYPQSFCVSHESSG**GK
MLQRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K
*SLPSA*FISRAYV*SIGTSKKDESDRFRNI*RC
SRTSAVFY*NS**TLQKWRDSSFTGTQLYHKTF
A**CGEREKGKIAKRNRGR*TKTRRRKKRS*KE
*RFLWCCRPLRLTSHIQPGL*L*KQHVPCWRLRL
CGTCRGQPTTTYRLY*KTVGGFSW*KMVVWLLV
LPTK*NIPPGYTKISRKRSF*E*LLQQSSS**N
SRQVCGHVCQGIL*VMPRKLPR*GCFCL*ITVFC
QNQIF*EN*TVDHAHQLSQVCPSGCASACGSRG
LCICKCR*R***EEYRQLRGQSS*RQF*LGKGK
RRCPCGNVQW*TRLPLL*AAPLQ*HVAEGWRLCL
HQVPWPGASSCGQN*KSMGSRWSCIFLWPHLHS
PRRNRA*AHKNVLQKRSISE*SGRNLPHDMYSR
KVCCVVIQGLPLLQAN*NTRK*HSAL*EPLQ*ER
Q
ADEEIQRIEEVFTLC*SGR**NLLLQKTNCSS
EGAITFAGKEDPVARS*ICRVRRWR**Y*RDGR
RR**GH*TSFSTSASDPPGQ*AGPHALHTPTVYP
KVCQRQCKEGRLQTENQHEWLHPVQQ*DEGCD*
GPTPRLLFRGAQPPGGDRMEKS*DSQESRI*RH
DGWLSARPSTFAGPS*WPC*HGQHAATSPWGAST
PPSSARCAWPPGHPTTGCDEPRSGPYGRDSSTR
WKSIWTTGGSFGASRAAGTTSISRPTSSWTPCH
TAANNTHVCSSPTKDPAASSLRGLPEIH*RTQCG
VQQH*QVGSDTGSSKTRRPFVERTGEPPTLSLA
EKQRGPHHHGRCPLAPSRFDAPGHPQHSPSIQP
RKCLITSLRFFYIEA*RVVDQ*PF*LLGVGGRNK
GG*FLLHFTVHHKAIFIYGHF**AISICLLY*V
DFIKYTKIFLHMFPSFKTSFIIGCICRLGVLSF
YLLPWN*NH*RFLSWLGVFVFLVLGFFIYIYKRT
K*KKTHTHKSLQISLN***NVKFVLVYILERGV
YLCLFHVPEYLKPLSAKAVSYR*SAFFERWLFR
F*MFNRHSTFALLTQRLTTEICNQCCASVCS*CT
SWTPGGEKALFQLC*VRHL*VRLWCQ*FLQNTC
TTLRYV*SRQVRLRIF*SIYNEFTIYAYKFQMI
*NFKPVTLKNIEVRLEESIKVCMEVIYF*T*HLT
*HG*ESMELDMSCIRSIIVNK*IDCLHIQVCFS
IPYFLIIRCIFSFKFQCCYNSQPEI*YFLKYFL
NLACAFELQEKGIII**NAY*KDHYRSQTLGFGD
PVFLI*PYNKHLKAA*DGRQ*EHCFTWRHVFET
CFIVTG*LPLW*SFHCCL*SERVNLRGCFFPFN
LL*ISTQMFNYCTY*IMRAKECRMEKSLLYLDTL
NMGGPLT*LPLVNHWI*ICIKYFK*Y*I*KNVL
Q*CVSTLLLK*VR*IFNSWLFGQLNHHGLYNAI
RLFCF*TSLNYTKEHEI*LWLNYLFISCIHFISL
KVWMRLLWGASKKIFHWGPRGSLEARALLQAPS
QCLEVL*ET*IQPGASLKQCSTGPGHH*TGPN*
VFFKKPVYLF*NHVFLYINLGDIVNI*DIRFEVS
HLQKRKKN*LKKVQVNYTPFFHKF*EL**CGLE
SIMA*MFSKCKFLWRRIVYIANGGTEGNL*V*N
SMFVSQLI*KAFNCFGCCFFFKPLSPSYEEELRG
APISVKSPNWC**F*A*MFSYLIKTWFILISVS
YHLRFTW*LVL*HVCIFFLLFI*SFLIQINTEF
AK*

Sequence NM_181042

TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCA
GGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAG
ACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAG
AAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTG
AATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGG
GCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCA
TCAGGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCA
TTGCCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGG
CTCTCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATG
AGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCACTAGCAAGTATTACCGTA
ATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCACGCTA
TGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAAC
CAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGA
TCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAA
TTCAGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATG
ATCTCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAG
CTCGAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAAT
GGACTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAGGCAC
TATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGATGATG
ACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGGTCTA
TGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACT
ATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTA
ATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGA
TGAGGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGC
TACAGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATC
GCTACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGT
AGAACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTTGCAT
AATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGTGAAG
ATTCCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCTATGT
GGAACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGGTGAAAAATGGTTGTATGGCTGTTGGTTTTAC
CGACCAAATGAAACATTCCACCTGGCTACACGAAAATTTCTAGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAAGTTCCAGTTAGTAAAATTCTAG
GCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCTGTGAATCACGGTATTCTGCCAA
AACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCTGCCTGTGGTTCGCGTGGCCTCT
GTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTTAACTTGGAAAAGGAAAAAGAAG
ATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGAAGGTTGGCGACTGTGTCTTCAT
CAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTATGGCCCCATCTTCATTCACCCA
GAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCCATGACATGTATTCTCGGAAAGT
GTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGAGCCGCTACAATGAGAGCGACAA
GCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAGAAAACCAATTGTTCCTCAGAAG
GAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGATATTGAAGAGATGGGAGAAGAAG
ATAGTGAGGTCATTGAACCTCCTTCTCTACCTCAGCTTCAGACCCCCCTGGCCAGTGAGCTGGACCTCATGCCCTACACACCCCCACAGTCTACCCCAAA
GTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCTACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAAGGCC
CAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGGTGTGATGA
ACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACC
TCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCAC
TCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATT
TGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGAT
GCTCCGGGACACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATC
AGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACA
CTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTC
ATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTT
TCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAA
TGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCT
TACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAA
TATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTG
AGTTAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTAT
AATGAATTCACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGG
TATGCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAA
CAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAAT
TCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACT
AGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACA
GTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCT
GAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAG
AGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCAT
CAAGTATTTTAAATAATATTGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTA
TTTGGGCAATTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGT
TAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACG
TGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGC
AGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGG
GGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTT
TTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATT
GCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTT
TTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTC
ATACCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTG
TTCATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTGCAAAGTGA
  • refseq_PB1.F5 (forward primer)
  • refseq_PB1.R5 (reverse primer)
  • Alternative donor

Frame 0

SMGSKRRRATSPSSSVSGDFDDGHHSVSTPGPS
RKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGR
LLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQ
KLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSP
EYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDG
QDNQGTVTEGSSPAYLKEILEQLLEAIVVATNP
SGRLISELFQKLPSKVQYPDYYAIIKEPIDLKT
IAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPG
SQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRM
RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR
NKRAVQGGRLSAITMALQYGSESEEDAALAAARY
EEGESEAESITSFMDVSNPFYQLYDTVRSCRNN
QGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQ
IRTKLKNQEYETLDHLECDLNLMFENAKRYNVPN
SAIYKRVLKLQQVMQAKKKELARRDDIEDGDSM
ISSATSDTGSAKRKSKKNIRKQRMKILFNVVLE
AREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPM
DLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARH
YNEEGSQVYNDAHILEKLLKEKRKELGPLPDDD
DMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVY
EAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLT
IKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMF
NNACTYNEPESLIYKDALVLHKVLLETRRDLEGD
EDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRC
YSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENN
RYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAV
ELQQFFIKIRDELCKNGEILLSPALSYTTKHLH
NDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYV
EPAEANLQPHIVCIERLWEDSAGEKWLYGCWFY
RPNETFHLATRKFLEKEVFKSDYYNKVPVSKIL
GKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAK
TKSFKKIKLWTMPISSVRFVPRDVPLPVVRVAS
VFANADKGDDEKNTDNSEDSRAEDNFNLEKEKE
DVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFI
KSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHP
EETEHEPTKMFYKKEVFLSNLEETCPMTCILGK
CAVLSFKDFLSCRPTEIPENDILLCESRYNESDK
QMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK
EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEE
DSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPK
SAKGSAKKEGSKRKINMSGYILFSSEMRAVIKA
QHPDYSFGELSRLVGTEWRNLETAKKAEYEGVM
NQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPP
PYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLH
SEAYLKYIEGLSAESNSISKWDQTLAARRRDVH
LSKEQESRLPSHWLKSKGAHTTMADALWRLRDLM
LRDTLNIRQAYNLENV*SHHYVSFI*KHKELWI
SSHFSYWGWGEGTKEDNFYCILLYITRPFLYTD
TFNKLFQFVCYIKLTLSNTQRFFCICFLRLKPVS
*LVVYVDLEFYLFTCCHGTETIRGFCLGLGFLF
SWFWVFLYIYIKEQNEKKHTHTRVYRLV*IDNE
M*SLS*FTS*RGEYTCVCFMCLNILSHFLQKLFL
TDEVLSLKGGYLGFRCLIDTAHLLY*LRGSLQK
YVISAVHLSAANVPPGHQEGKKHFFNCAELDIC
ELDYGVSDFCRTRAQP*GMFNLGRYV*GYFDLFI
MNSQFMPINFR*FKILNLLH*KTLKFVLKKALR
YAWR*FIFKHNT*PNMGKRVWN*I*AV*EA*L*
TSRLIAFIYKYVLVFLISLLSDVFFLLSFNVVII
LNQKFNTF*NIF*I*LVLLNYRRRES*FNKTLT
RKTITDPKHLGLVTLSFLYDPTINI*RQHRMAD
SRNIVSLGGMFLKPAL**LGDCHCGRASTAVYNL
RELISEDAFFLLICYESVPRCLITVLIKS*GQK
SVEWKKVSCI*IL*IWEAL*LNCL*STTGFEFA
SSILNNIEFKKMYCSSVSVPYC*SESDKSSIPGY
LGN*IIMDCIMQSDYFVSRHP*ITPKNMKFSCG
*IIYLFHAFILFPLRSG*DFFGEPLKKFFTGGH
VGH*KPELSSRLLPSA*RCYRKHRSSQGLP*SSA
APAQGITRQALIKFFLKSLCIYFRIMFFCILTW
GISLIFRI*DLRSAIFKKEKKIDSRKYK*TIHL
FFISFRNCSNVA*KV*WPKCFQNVSSCGEELFIL
QTGGLRGTCRFKTVCLSAN*FKRPLTVLVVVFF
LSHSPLPMRKN*EGHLFL*NPQIGVDDFELECF
HT*LKLGLF*FLYHII*GLRGN*SYNMYVSFFCC
SSKAF*SK*IQSLQS

Frame 1

PWVPREEELPPLPAVSAGTLMMGTILCQHQAQA
GKGGDFPIFQL*ILLPCAMNSIIPSETIRMNRA
DFSVSSSLGHQSEEINQTIMKWFLSPLT**KSNR
N*KWKSMMMLIC*LLTSSFFLTMQSPIISQILL
NIKPLANSGICTFEQEMSLFRKEKQMTKMMMKM
GKTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIH
QDVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRP
LPRGYRMEATKVFMQWPKI*ISSQKMPKLIMSL
ALKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE*
GLHPTWLQPD*QVLHTVKAALVKREIPLASITV
IKEQYKEVVYQQLQWHFNMAQKVKKMLL*LLHA
MKRESQKQKASLPLWMFQILFISFMTQLGVVGIT
KGS**LNLFTICLQRKNTLIITSKLKCPYHYNR
SEQN*RIKNMKL*IIWSVI*I*CLKMPNAIMCP
IQPSTSEF*NCSKLCRQRRKSLPGETISRTETA*
SLQPPLILVVPKEKVKRT*ESSE*KSYSMLFLK
LESQVQAEDFVTYLWLNHPKRTILIIIKSSWSQ
WT*K*LSITSAMTNMLVKRE**KT*S*CSGMPGT
IMRRAPRFIMMHISWRSYSRRKGKSWAHCLMMM
TWLLPNSS*VGRVAFLLKNQNT*LQCSRN*MRS
MKL*RTILIRGVAASVPYF*GFPLDLSCLTTI*L
LKSPWTWKKFEVT*WPTSTKILTLWLRTLS*CL
IMPVHTMSRSL*STKMLLFYTKSCLKHAETWRE
MRTLMSQM*LC*FKSLSTIFLCQS*VIRMMREDA
TAIL*QKFLLWIPTFLTNHPLHLT*LGRMLKII
ATVGLIYFKSICLKYWNEQEG*IGQIQKYMKMQ
*NFSSFLLKFVMNSAKMERFFFHRHSAIPQNICI
MMWRKRERKNCQKK*RKIN*NEKKKKEKLKRVK
IPLVLQASQAYIAHTARTVALKTACTMLEITSM
WNLQRPTYNHISSVLKDCGRIQLVKNGCMAVGFT
DQMKHSTWLHENF*KKKFLRVTITTKFQLVKF*
ASVWSCLSRNTLSYAQKTSEMRMFLSVNHGILP
KPNLLRKLNCGPCPSAQSGLSLGMCLCLWFAWPL
YLQMQIKVMMRRIQTTQRTVELKTILTWKRKKK
MSLWKCPMVNQVATTLSSSITMTCG*RLATVSS
SSPMAWCVLVWAELKKYGFEMELHIFMAPSSFTQ
KKQSMSPQKCSTKKKYF*VIWKKPAP*HVFSES
VLCCHSRTSSPAGQLKYQKMTFCFVRAATMRAT
SR*RNSKD*RGFHSLLKW*MMKFTTSENQLFLRR
SHHLCWKRRSSC*KLNLPS*KVEMMILKRWEKK
IVRSLNLLLYLSFRPPWPVSWTSCPTHPHSLPQ
SLPKAVQRRKAPNGKST*VATSCSAVR*GL*LRP
NTQTTLSGSSAAWWGQNGEILRQPRKQNMKV**
TKEWPLW*GLQHQVEVHMDNRWEFWGLQGSRHH
LHIPAHIQLDPLSYSSQQHPCL*LPHQRPSGFFT
QRPT*NTLKDSVRSPTALASGIRHWQLEDATSI
CRKNRRAAYPLTG*KAKGPTPPWQMPSGAFEI*
CSGTPSTFAKHTT*KMFNHIITFLLYRSIKSCGS
VAILVTGGGGKEQRRIIFIAFYCTSQGHFYIRT
LLISYFNLFVILS*LYQIHKDFFAYVSFV*NQF
HNWLYM*TWSFIFLLVAMELKPLEVFVLAWGFCF
LGFGFFYIYI*KNKMKKNTHTQEFTD*FKLIMK
CEVCPSLHLREGSILVFVSCA*IS*ATFCKSCF
LQMKCFL*KVVI*VLDV**TQHICSINSEAHYRN
M*SVLCICLQLMYLLDTRRGKSTFSIVLS*TSV
S*TMVSVIFAEHVHNPEVCLI*AGTFKDILIYL
**IHNLCL*ISDDLKF*TCYIEKH*SSS*RKH*G
MHGGDLFLNITPNLTWVREYGTRYELYKKHNCE
QVD*LPSYTSMF*YSLFPYYQMYFFF*VSMLL*
FSTRNLILSKIFFKFSLCF*ITGEGNHNLIKRLL
ERPLQIPNTWVW*PCLSYMTLQ*TFEGSIGWQT
VGTLFHLAACF*NLLYSNWVIAIVVELPLLFII
*ES*SQRMLFSF*SAMNQYPDV*LLYLLNHEGKR
V*NGKKSLVSRYFKYGRPFNLIAFSQPLDLNLH
QVF*IILNLKKCIAVVCQYLIVKVSQINLQFLA
IWAIESSWTV*CNQIILFLDILELHQRT*NLVVV
KLFIYFMHSFYFP*GLDETSLGSL*KNFSLGAT
WVIRSQSSPPGSFPVPRGAIGNIDPARGFPKAV
QHRPRASLDRP*LSFF*KACVFILESCFSVY*LG
GYR*YLGYKI*GQPSSKKKKKLTQESTSKLYTF
FS*VLGTVVMWLRKYNGLNVFKM*VPVEKNCLY
CKRGD*GEPVGLKQYVCQPTDLKGL*LFWLLFFF
*ATLPFL*GRIERGTYFCKIPKLVLMILSLNVF
IPD*NLVYSNFCIISSEVYVVTSLITCMYLFFV
VHLKLFNPNKYRVCKV

Frame 2

HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQ
EKEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQ
TSL*ALH*GTKAKKSTRLL*SGFSAH*LDENPT
ETKNGRV**C*FADC*LPASF*QCKVLL*ARFS*
I*SRLQTLGFVPSNKK*VCSERRSR*RR***RW
ARQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKS
IRTSH*RTFSETAF*SAISRLLCNN*GAYRSQDH
CPEDTEWKLQKYSCNGQRYRSPRKKCQNL**AW
LSSIQGCKFN*KNILYEKG*N*TS*NG*VKSSN
EDSIQLGCSQTDRSFTQ*RQPW*REKSH*QVLP*
*KSSTRRSFISNYNGTSIWLRK*RRCCFSCCTL
*RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE*
PRAANS*TFLPFAFKEKIP*LLPAN*NAHITTTD
PNKTEESRI*NFRSFGV*SEFNV*KCQTL*CAQ
FSHLQASSKIAASYAGKEERACQERRYRGRRQH
DLFSHL*YW*CQKKK*KEHKKAANENLIQCCS*S
SRARFRQKTL*PIYG*TIQKGLS*LL*NHLGAN
GLENN*A*HPQ*QICW*RGNDRRHEADVPECQA
L**GGLPGL**CTYPGEVTQGEKERAGPTA****
HGFSQTQAE*EEWHFS*KIKIHDSNAAETK*GL
*SCKELY**EGSPPQCHISEASL*I*VA*LLSD
Y*KAHGHGKNSKSHDGQQVPRY*LYG*GLCHDV*
*CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGGR
*GLSCPKCDFADSRAYPQSFCVSHESSG**GKM
LQRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K*S
LPSA*FISRAYV*SIGTSKKDESDRFRNI*RCS
RTSAVFY*NS**TLQKWRDSSFTGTQLYHKTFA
**CGEREKGKIAKRNRGR*TKTRRRKKRS*KE*R
FLWCCRPLRLTSHIQPGL*L*KQHVPCWRLRLC
GTCRGQPTTTYRLY*KTVGGFSW*KMVVWLLVL
PTK*NIPPGYTKISRKRSF*E*LLQQSSS**NSR
QVCGHVCQGIL*VMPRKLPR*GCFCL*ITVFCQ
NQIF*EN*TVDHAHQLSQVCPSGCASACGSRGL
CICKCR*R***EEYRQLRGQSS*RQF*LGKGKRR
CPCGNVQW*TRLPLL*AAPLQ*HVAEGWRLCLH
QVPWPGASSCGQN*KSMGSRWSCIFLWPHLHSP
RRNRA*AHKNVLQKRSISE*SGRNLPHDMYSRKV
CCVVIQGLPLLQAN*NTRK*HSAL*EPLQ*ERQ
ADEEIQRIEEVFTLC*SGR**NLLLQKTNCSSE
GAITFAGKEDPVARS*ICRVRRWR**Y*RDGRRR
**GH*TSFSTSASDPPGQ*AGPHALHTPTVYPK
VCQRQCKEGRLQTENQHEWLHPVQQ*DEGCD*G
PTPRLLFRGAQPPGGDRMEKS*DSQESRI*RCDE
PRSGPYGRDSSTRWKSIWTTGGSFGASRAAGTT
SISRPTSSWTPCHTAANNTHVCSSPTKDPAASS
LRGLPEIH*RTQCGVQQH*QVGSDTGSSKTRRPF
VERTGEPPTLSLAEKQRGPHHHGRCPLAPSRFD
APGHPQHSPSIQPRKCLITSLRFFYIEA*RVVD
Q*PF*LLGVGGRNKGG*FLLHFTVHHKAIFIYGH
F**AISICLLY*VDFIKYTKIFLHMFPSFKTSF
IIGCICRLGVLSFYLLPWN*NH*RFLSWLGVFV
FLVLGFFIYIYKRTK*KKTHTHKSLQISLN***N
VKFVLVYILERGVYLCLFHVPEYLKPLSAKAVS
YR*SAFFERWLFRF*MFNRHSTFALLTQRLTTE
ICNQCCASVCS*CTSWTPGGEKALFQLC*VRHL*
VRLWCQ*FLQNTCTTLRYV*SRQVRLRIF*SIY
NEFTIYAYKFQMI*NFKPVTLKNIEVRLEESIK
VCMEVIYF*T*HLT*HG*ESMELDMSCIRSIIVN
K*IDCLHIQVCFSIPYFLIIRCIFSFKFQCCYN
SQPEI*YFLKYFLNLACAFELQEKGIII**NAY
*KDHYRSQTLGFGDPVFLI*PYNKHLKAA*DGRQ
*EHCFTWRHVFETCFIVTG*LPLW*SFHCCL*S
ERVNLRGCFFPFNLL*ISTQMFNYCTY*IMRAK
ECRMEKSLLYLDTLNMGGPLT*LPLVNHWI*ICI
KYFK*Y*I*KNVLQ*CVSTLLLK*VR*IFNSWL
FGQLNHHGLYNAIRLFCF*TSLNYTKEHEI*LW
LNYLFISCIHFISLKVWMRLLWGASKKIFHWGPR
GSLEARALLQAPSQCLEVL*ET*IQPGASLKQC
STGPGHH*TGPN*VFFKKPVYLF*NHVFLYINL
GDIVNI*DIRFEVSHLQKRKKN*LKKVQVNYTPF
FHKF*EL**CGLESIMA*MFSKCKFLWRRIVYI
ANGGTEGNL*V*NSMFVSQLI*KAFNCFGCCFF
FKPLSPSYEEELRGAPISVKSPNWC**F*A*MFS
YLIKTWFILISVSYHLRFTW*LVL*HVCIFFLL
FI*SFLIQINTEFAK*

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