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Sequences

Sequence NM_002481

GGCGGGAGGAGTAAAGATGGCGGCGCGAGGGTCTCCGCCCTCTGCTCCGGGCTGAAGCGCTCTGAGAGAGGCGGCAGCGGCAACTCGAGCCCCAACAGTA ATTTAGTGTTGGTAGTTTTGGCAGCAGCTGCCGAGGCCGGAGCAATGGCGGAACTGGAGCACCTAGGAGGGAAGCGGGCAGAGTCGGCGCGAATGCGGCG GGCAGAGCAGCTTCGGCGCTGGCGGGGCTCGCTGACAGAGCAGGAGCCTGCGGAGCGACGAGGCGCGGGGCGGCAGCCGCTGACCAGGCGCGGGAGCCCC AGGGTCCGCTTCGAGGACGGTGCTGTCTTTCTGGCCGCCTGCTCTAGCGGGGACACCGACGAGGTGAGAAAGCTTCTGGCAAGAGGTGCTGATATCAACA CGGTCAACGTGGACGGCTTGACAGCCCTGCACCAGGCATGTATTGATGAAAATTTGGACATGGTGAAGTTTCTGGTGGAGAACAGAGCCAATGTAAACCA GCAAGACAACGAGGGCTGGACACCCCTTCATGCAGCAGCTTCCTGTGGCTATCTCAACATAGCAGAGTATTTCATTAATCACGGAGCCAGTGTAGGTATT GTCAATAGTGAAGGTGAAGTTCCCTCTGACCTTGCAGAAGAGCCAGCCATGAAGGATCTTCTTCTGGAGCAAGTAAAGAAGCAAGGAGTTGATCTAGAGC AGTCAAGAAAAGAAGAAGAGCAGCAGATGTTGCAGGATGCCCGCCAGTGGCTCAACAGTGGGAAAATAGAGGATGTGAGGCAGGCTCGCTCAGGGGCTAC AGCCCTTCATGTGGCTGCTGCCAAGGGCTACTCTGAAGTCCTCAGACTTTTAATTCAGGCTGGCTATGAACTCAATGTTCAGGATTATGATGGCTGGACT CCCCTCCATGCTGCTGCACACTGGGGAGTGAAGGAGGCTTGCTCCATCCTGGCAGAAGCACTTTGTGACATGGATATTCGAAATAAACTGGGCCAGACAC CATTTGATGTGGCTGATGAGGGTCTCGTGGAGCATTTGGAGTTGCTCCAGAAGAAGCAGAATGTGCTTCGAAGTGAAAAGGAGACACGGAATAAACTCAT TGAGTCAGATCTGAACAGCAAGATTCAGAGTGGGTTCTTTAAGAACAAAGAGAAGATGCTCTATGAGGAGGAGACACCTAAGTCCCAAGAAATGGAGGAA GAAAATAAAGAATCTAGTAGCTCCAGCTCAGAGGAGGAGGAAGGTGAAGATGAAGCTTCTGAGTCAGAAACTGAGAAGGAGGCAGATAAAAAGCCAGAAG CCTTTGTCAATCATTCCAACTCTGAAAGCAAGAGTAGTATCACAGAGCAGATACCAGCACCAGCTCAAAATACCTTCTCTGCCTCTTCTGCTAGGAGGTT CTCTTCTGGCCTTTTTAACAAGCCAGAAGAGCCCAAAGATGAATCTCCTTCTTCATGGAGATTGGGACTGAGAAAAACTGGCAGCCACAACATGCTGAGT GAGGTGGCCAATTCCAGGGAACCTATAAGGGACCGAGGCTCTTCCATCTATCGCTCCTCTTCAAGCCCTCGGATTTCTGCTCTACTGGACAACAAAGATA AGGAGAGAGAAAACAAAAGCTATATTAGTTCACTAGCACCCCGGAAGCTCAACAGCACAAGTGATATTGAAGAAAAGGAGAACAGAGAATCAGCTGTTAA TCTAGTGAGGAGTGGCTCCTATACCCGGCAGCTATGGAGGGATGAAGCAAAAGGAAATGAAATCCCACAGACAATTGCTCCCTCCACCTATGTATCAACT TACTTGAAAAGGACTCCTCACAAATCCCAGGCCGACACAACAGCAGAGAAAACAGCAGACAATGTCTCTTCTAGCACCCCGCTCTGTGTGATCACCAATC GCCCTCTTCCTAGCACTGCCAATGGGGTTACAGCTACTCCTGTGCTCTCCATTACTGGAACAGATTCCTCTGTGGAAGCCAGGGAGAAGAGGAGGTCCTA TCTGACTCCTGTACGGGATGAGGAAGCAGAGTCTTTACGGAAAGCACGCTCCAGACAAGCTCGGCAGACACGAAGGTCTACTCAAGGTGTCACCCTAACA GACCTTCAAGAAGCAGAAAGGACATTCAGCCGGTCGAGGGCAGAGAGGCAAGCTCAGGAGCAGCCTCGTGAGAAGCCCACAGACACTGAAGGGCTTGAGG GGAGCCCTGAGAAGCATGAGCCCTCAGCAGTTCCAGCAACAGAAGCTGGGGAGGGCCAGCAGCCCTGGGGCAGGAGTCTGGATGAAGAGCCTATCTGTCA TCGCCTGAGGTGCCCAGCTCAGCCAGACAAACCCACCACGCCAGCATCTCCTTCTACGTCAAGACCCTCACTCTACACCAGTTCCCACCTGCTATGGACA AATAGATTTTCAGTCCCTGATTCTGAGAGTTCAGAGACTACCACAAACACTACAACTGCAAAGGAAATGGACAAAAATGAGAATGAAGAAGCAGATTTGG ATGAGCAGTCCTCTAAGAGGCTGTCCATCCGAGAGAGGAGGCGGCCCAAGGAACGACGAAGAGGCACAGGCATCAATTTCTGGACAAAGGATGAGGATGA AACTGATGGCTCTGAAGAGGTCAAAGAAACGTGGCATGAAAGACTTTCTAGGTTGGAATCGGGAGGTAGTAATCCTACAACCAGTGATTCTTACGGTGAC CGGGCTTCAGCAAGAGCCCGTCGGGAGGCCCGGGAGGCCCGCCTAGCCACCCTGACCAGCCGTGTAGAAGAAGACAGCAACAGAGATTATAAAAAACTCT ATGAGAGTGCTCTGACTGAAAACCAAAAACTGAAAACAAAACTTCAGGAAGCCCAGCTAGAGCTAGCAGATATAAAGTCCAAGCTTGAGAAGGTGGCCCA GCAGAAACAAGAAAAGACCTCTGACCGATCATCAGTGCTGGAGATGGAGAAACGGGAGAGGCGAGCCTTGGAGCGCAAAATGTCAGAAATGGAGGAAGAA ATGAAGGTGTTAACAGAACTGAAATCCGACAACCAGAGGCTGAAAGATGAAAATGGTGCCCTCATCAGAGTCATCAGCAAACTGTCCAAGTAGGCTAGGC TCCAGATTTATGAGGAAAGAAAGGGACAGCATTTGCTGCCCCCACCCCTCTTTTCCAGTCCTTGCCTTCCAACCAAAAGAAATGGATGTTTTGGTGGAAG GACACTTCTTTCTATCACCCTCTTCAGTCACCTCTATACACTCTACATTTTCTCTGCACTTTCAATGCCCTGTTCTTCCAAACCCCTATCCCAAGTTTTA TGACAGTTTTAATTGAAGCATGATTGTGGTAATTCGAGCCATCTGGAGAATGCTCTGGGGAGTACACCAGGCTCAGCTGTGGACCCCTCAACTTCCTGCT GCTCAGCTACTTTGTCCACATTGGATTTGGTCCAAACATGTAAGACTTCTACCCTAATCAGTATCCTTCAGCTTTTTACATTAACCCAGTGTCCTCTGAT ATAGGTGAGTCTTGTGGTAGCCACTCCAGGATCCTGATTGGGGTGCCAAGAGAAACAGCAGGATGTTGAATTGATCATCAGATGCCCTCTGGAATGGTTA GCATCCAAGGTGACAGTGACTGCATTGAGGCGCTCTATTCTTCTTCACCTCTCAGGAACTGACTTTTATTTTTTCTGTCAACACCCAGTAATCTCCCTAA CTAGTTTTAACCCTTATTCCTCCCTCATACCTAGCCATTTCTCCAAGGCGCAAATGGCCCTGGCTTCATTTATTCCTTTCCTTTCTATCCTTTTATATTT TTCCCTTCCCCACCCCCTCACTCAATGGTATAAAAGCTAGGACAGAGCACCTGACCTCAGTTGTCTTTGGCCATTGTGGGAAGTCATTATTCTGGAGACA AGAAAATCATCACTCTGGTGCCTTGGTGGCAGCACCACTGCCTGCTCCCTGGAAGGTAGACTATGGCATAAGTGTCAGCTCATTGTTTTCGTCTCCCACT TATCTTCCCCCTTCAAAGTGATTTTCTTTATAAGAAAATTTGGGCTCTGAATACTCCATTCTGCCTCACTTCCTTGACCTTGTTTTCCTCTCTTCGCCCT GACACCTGCTTCTAATGAGAAATGAAGTCAGTGCAAGGAGGAATGAGAGGTGGGGAGGGGAGATTGTTGAGAGATGGACTAGGAAGTGGAAGCAGGCTGG AAAGACACATATGGCGAAAGTCAAGTATCTGAGGCCACTTGCAACATTGTGACAAAGAAGATGGAAGATAGCAGCCTACTGGGCTGTGAGAATAGTGGTG AATTTGATTATTTCCAGTGGTTAGATTTAGCAGAGAGATTTACTTTCTTAGAAATTAATAGGGGAAATGGCACTTAATAGAGGTTTAATGGAATGAAGTA CTTTCAACCCATTGATGAGAGTCATGGAAGTTTAGAGTGGCAAGACCCAGAGGTCATTAGGTCCAGCTTTCTATTATTGTGTCACAGGGACCCCTGCTAC CACAGCTTTCACCCATGGGCATGGTCAGGTAGCCTCTGGTGGCTATGCATTTATTACTCAAAAGTTGGGCAACTCTAATAACGAGAGAGTTTTTCCTCAT ATCAGCTGAAGTCTGCCTGTGGATTCTCCTTGTAGTCCAGATCTACTATCTGCAACTCTTTAACGGCACTTGAGATATGTGCAGTGGGTGGTCTCCCCCT CAGTCTTACTTTGAGCTGCTGTTACTCTAGTCCTTTAAGTCATTCCTCATATGGCATGCTTTTCTTACCTGTCACATCTTGGCCATCCTCCTCTAGACAA AACCAGCCTTTAAAATATCATGTCCAGGCCTGGAAAGAATACAAATCCAGTGCAAAATTAAACCATTAGTTCTTGATGATAACCTAGCATTAATACTTAC AGTATTTTCTTTTTGTAGGAGTTTTATCCCTTGGTTCACTTGAGTGTGCAAGTCATTAAATCCTCATCATTTTAGGGTTGCCAGTGATATTCAGTGTTTA GAGTGGTTCATTCCCTTAATATATACTACCTCTGTCTGTTAATTCTTTCCTAACATGACATGTAGCTCTCCATGGTCCTCCCTCTGAAACACCACATGCT GTTTAAACTAGAAGCTGTAATTCAAGATCCCAATTCCACCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTCAGGAGGCCGAGGTGGACAGATCAC GAGGTCAGGAGTTCGAGACCATCCTGGCTAACACGGTGAAACCCAATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTAGTC CCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCTTGATCACGCCACTGCACTCCAGCCTGGGTGACA GAGCAAGACTCCATCTCAAAAAAAATAATAATAATAAATAAATAAAAAATCCCAATTACAGAACAGGAGATATGTTTCCTCTGACAAAACCCCATTTTTA GAGTGTATAAAATTCTGTCTTTCATTTCCAACCATTTTTCAAGAGAAGCTGCTACTATCTTGAGACTTCGTATTATCATGGGAGTACTGTAAGTTCAGTT CTCAGGGAATGCTAAATTAGAGTAATAAGTTTTATATCCTTCATTCTGGGAGAGGAAATCAACATAAGGTGTTGACTAATTGATTATCCTGGAACATTTT GAATATTGGGGAAGGAAGATGATACTTCTTTCTCAAGAAAAGAAAATTGGATTATTAGGAATACATCTTGACCCTTTTCCACTCAATAGACCAGGGAAAG GGGTTACAGAGAGCCTCCTCAGATCTGTTTGTGCCTTTCAAAAGTACTGGGGGCAGATTCTCAAAACTCTTAGATTGGTGTTGCATCCCTGCCACTTCAC ATGACCCTTCCATGTTAAAGCTGACTTTTCTTGCCAGAAAGTTTTCCTTGTGACAAGAAATTTGCAAGCTTTTCAATCTCAGGAATACTGGATTCTATAG CCAAGAACTCATGAAAGTAAGTGTAAACTATCCTAGGTAATTTCAGGTACTTTCTCTTATGCAATTAATTTTATTAACTGATTTCTGGTCTATCTCCAGA GATAAAATACCATTCCTTCACAACTGTATTGTCTGGAAGCCCCATGAGATGGTAATTATAGGCCTTCTACTAGCCAGCAGTTCTCTCTGGATACTGGCAT CAGCAGGTCTCCTTTTTCTTGTGCTGCTTGGACAGGTACCTACTGCTGGCCTCTTCAGTGGCCACAATCCTCAGTCCTCACCTGCTGGTTTGGAGACTCA TGAGCACCCCAGGCAGCTCAAGCTGAATAAATAGCTGCAGACATGGCCAACAACATGGGGCTCAGGTCTGTCACTTAACTTAGAGTCTTTACATGAAATA TCAGAATGGGAAAGAGAATGTTCCTGGTAAAACTCTGTTTTCATTAATTTGTTATTTTTCAAAAACCGAGCCACACCTTTGGAAGTAATGATTTGGCCAT TCCAGAGATTCTGGGGCTAAAGTTTGTTTTTCCAGGGCTGCTGATCCTTTTCCAGATAGCTCCAGAGTATGATGACCCCAGCCCCATCCCAATCTCTAGC GAAAGGGTTATGCAAATCTCAGGGTGTTGCCTCTAAAGAATCTAAAGAATAGACATGCTTTGGGCTTACTCAGTGTACCAGATTCTCTAGTGGGCCATTC TCATTTGATGTTCCCTAGAACCTCCCTGTCTTCCAACTGCAGGATGTGTTTACTTCTCTTCTGGGCTTCCCCTGGTTTCTGTCCTAGTTCCCACCCCAAG TTTAAGAAGACTTAGATTCATTTATTGCTATCTGAGGCCACTAGTGAGATTTCAGATCTCTCTTTTGCAACATTTTACCCATTTCCCTTCCCCAAACCAT GTGCTTATTAGATGGTTCCACTCAGGAAGCAAGGAAGCTAAAACTCAAGTTAATGGTCTGTGGATCCCACGAAAGTGTGTGTAAACTACTGACTGTTTCT CCACTAGAGGCATTTAATTGAGCCAAAGATGATGGAAGAAGAAACTCTCAAAGCCATGTACTTTGTTAGGTGTCTGGATTTTTGGCCTGTTTGCAGCCTC TCCTAGCCACAGACAGACACTGTCTCCTCTCAGAGAAAGGCCAGTGTTTCGGTCCAGGCCACTGGTGAGTGTCGGCACCCTTGAGGTGGGCATGGAGTGA GCAGAAGAAGCCTGGAGAAGAGAGAACTATTTAAAAGTGTTGCCAGTTATTCAGCTTCCAGGCGGCTTTGCACCTCCAAAGGTGCAAAAAGGAAAAAGAA AGCAGAAAGGATTCAGCATTTAAGCAGAAAGAAAAGGGAAATTCTACTCTACCAGATGAGCCACTGGTTCCACTGGAGCTTATCAGTGAAGTAACACTGC AGGAGCCCTGGTATCCTTCCCTCAGAGATATCATCAGGGGCCCTCAAACCCCATTGTTTATGCCAGCACTGACCGCACTTTAAGCACACACTTACCAATC AGAGGTCGTGTAATTGGCCTAAATCTAGGCCCAGTTATTACTACAAATCTTAGTCACCATACTCTCTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAG CTCACTGCAACCTCCACCTCCCAGGCTCAAGGGATCCTCTCACCTCAGCTCCCGAGCAGCTAGGACTGCAGGTGTGCACCACCATGCCCAGCTAATTTTT GAATTTTTTTGTAGAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTGAAGCTGCTGGGCTCAAGCAATCCACCTGGCTGGGCCTCCCAAAGCGATAGG ATTACAGGCGTAAGGGCCCACGCCCAGCCTACCATACTGATTTTCAAGGCAGGGTCTAACCCTTCATAAGATGTGAGTTCTTCCAACCCAATAAGCAGGC AGCTTTGAGGACAAAAAGGCAACATTAAAAGATAAGACCCTAGAAGTCAGAACATCTGTATTCCAAGGCCACCCCTTCTCCTTTTAGTCATGTGACTTTG GGCAGGTCACCCTCCCTGTCTGTAAAATGAGGTTGGACTGGATAATCTTTATGTGCCCTTTCCTTTTGGCTTAAAATTCTGTGATTTATTCATTCTTAGG AAGATCAGCATATTTATTGGGATTTCTGCTTCAAAAATTCTTTCTAACCTCAAAAATCCAAGTCCAGAATTTTTTGTTTTCTTCTGGATTTAAACTGTTT AATATGAGCACATCAAGGTTGACTTCTCATCCTTTTTGGGAAGTGAATTTAATATTGAGGGTAATTGAATGATGTTGCAATGGCTTTCCCTCCTGCTGGC TTGGTAAGAATATTAAAGCCTGCAGAGGTGGAAATTGGAGCTCATGGAGAAATGGATAGAAAGCAATTTGTTGCAGGCAGCCTTTGGACAAGTTGTTTTA ATAGGAAATAGACCTGCTGCTTCATAGGTTTCCTCAACCACCTTTCCTCAGCTTTCTTAAAATGGGATCTACATTGGCTCTTCACACCCAAATAGCAGAC TAATCGTTTTTCTGCTTAGCACCGTCTGGTTCATTGTCTTGAACTCTGCCTTACAGCAGCAAGAAAATTTTCCTCGACAAGAACCTCAATCTTTAGTTCC ATTGAGCTCCCCCTCTGGATTTTGGACTTACCAGAAGTAGGAGGTTCTGATACCATTCAAGATGGTCTTTCCTTCAAAGCAGGTCTGAAGAGGAGACTAC CAAAGCAGTGTTTACAAACCCAGAGTCCACACAACCATATTGCATAGAACAGCACTTGGCTTTCACAAGCCTCCTACAGGACCTGGTGTAATTGGAGTGA AAGGGCAGAGACCCTGGAAGTGGAGGTGGCTGTGTGCTGCGATGGGAAGAAGGCAGAAGGCCCAGGGGCTTTGGACATAGAGCAGGGTGGAAGCTGCAAG TACTGGGAAGGAAGAGAGTTTCACAGAAACAAAGCTTTGTCACACAGAAATGAGTTCTGTCTCACTGGTGACTTCATCCCTCAGGCTCCAGCTGAGCAGA GATTTTAATCAGCTTCCTTAATGGGTATTGACACTGCTCAGGAAGCAGTAGACCCTGTCAGGGACAGCTATTGATCTTTTGTGTTCTGATTAGATTGGAA AATAGATCAACTTCATTGTAGTCCAGGAACTGTTGGTCACAGCTACTAGGAATGAGGTGATTTCTGAGGGCTGAGAAAAAACACAGAATCTTGGCCAGCA GCCAGCAGCTGCATGGTGAAAGATGCATTCACTTCTCCTTTGAGAGTTGGGGTTGAGGGCAAACATAGAACCCAGGTTTGGCTTACAACCCAGTGTCCCG GAAGCCCTCCTTCGGGAGAACTGTAAGTAAGAGGTGGGTGTGTCTAAAGACAATACCATTAATGAATGTTCTGGCCTTACCTAAAAAGGTTTAGCAATTT GGGGATAACTCTTGGATCTAGCTTATGTGCGTTCACATGCACATTTGCTAGCCCAGAGCTTTTAAAATGAGGTCTGGCATATACTTGATTACAAATGAAA ACTCAGAAACCAATTTTATTTATTAAATCATATCTTTTGTTTTTCCCCCTCCCTTCTAATCCCCCAAAGGACCTATTTGAGCTGTTCCCCAATTCATCTG CTTATTTTGGACCATGAATCTGCCAGAGTGATATTTTCTGTTATTTCTCCTCCAAATTTTTCCCTGATGTTTCCAATAAAGATTTACTTGGGTGGCCCCT TAAGGTGACATCAGGATGCTCTTATGTCCTTCCAGAATAAGCATACACTTCACTCCTCTCCCTTTCATCTCCCTCTGCATTCTTAATTCCTTGCTTTTCT CACTTGGAGCCGAGGGTGCTTTAGAGAGGTGGTTTTCCATGAATCAGCCAAGATTCCTGTAGAAGTTGGGTATACCAACCACCACCACCACCGCCCCCTA TTCCAGTTTCAAAGCTCCTCGGCTATGCTAATGTCCCCTCAGAGATGAGGTTTGACTTTTAGGCCCGTATGACTCCTCCATAGCCTGGCCAAGGAGACCA TGAGTAGCCATGTCTGGTTTACTCTTTATCCTGAGACTGTTTATAGCTTAAAACAGAAGTGTGTCTTCCCAGCACAAACCTAATCAATCAGTGTATCAGT GCATCTGGTGGCAACAGCTCAGCCCATTCAAAGAGCAAGGATTCAGGAAAGGCACACTGATGGTGGGGAGCCTCTTAAGAGCCTCTAATGTTCTCCCAAA ACCAGAGTTGAGAGTCGGAGTGCCAGTCGTCGGGGCCCACTATTCCTGAATAAGGGACATGCAAGGGCCAGAAGTAGCTTGACTCTCGCCTAAATATCTG TGCCTTTGCCTGTCCTTTCTCCCACTCTACTGAAACCCGGAACAGATTCCCGCTTGCCTTCTGATGAAGAGAGGTTAGGTAAAGAGAGTTTGGAGGAAAA AAGACACCAGGAGGCAGGCTGCGGGGTAGGAGAGGGTTCTGAGAGGAGGCAGCAATCCAGAATACCTCCTTTTCTAGCCAGCATCCCTTGAACTTTTGAA AGGTTGTGCCTACCACTGGCTGGCACACCAGGGCAATGATTTCCCTGCAGAAGGAAGGAAAGAATGTTTCACCCTTGCATCCTTCTTGGAGAAGCTACAG CCTGTGCTCAGTTGAGTGGTTCACACTCAGACTTTGGCTTTATGGTTTTCCTTCCTCCTTGTCTTTGCCCTGACCTTGATCAACAGGGGTGAAAAGAACC ACCCTGAGGTTTCCATGCCTCTCCCATTTTAGTGGTAGCATTTTGTGTCTTTACTCCACCCTTCACCCTAGTTCCACCAAGGTTCACACACCAGATGTAA CTGTTTTTCAGCTGAGTTGTATGGATTAACTTCAGTCCACTGTAAATACACCTGGGATGGGGTGGGGTTGGGGTTGTTTAGGGAGAAGCAGCCAGACTTG CTTTGTGAACTGAATGTATTTTTATGCAATTTTGAGTGGCCTTTCAACCCTAAGATGAATGGTTTTGTTTTACTGGTTGTTGTTATATAGTTTTGAGTAT TCTGTGTTTGAAAGTTTGGGAATAATAATATTCACTTCTATATGATGCCTGTAAACACAACAGTATTTATAAATGAGTAAATAAAACTGTGTTTTAACTT TG

refseq_PPP1R12B.F1 (forward primer)
refseq_PPP1R12B.R1 (reverse primer)
Single exon skipping

Frame 0

GGRSKDGGARVSALCSGLKRSERGGSGNSSPNS NLVLVVLAAAAEAGAMAELEHLGGKRAESARMRR AEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP RVRFEDGAVFLAACSSGDTDEVRKLLARGADIN TVNVDGLTALHQACIDENLDMVKFLVENRANVNQ QDNEGWTPLHAAASCGYLNIAEYFINHGASVGI VNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLE QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGAT ALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWT PLHAAAHWGVKEACSILAEALCDMDIRNKLGQT PFDVADEGLVEHLELLQKKQNVLRSEKETRNKLI ESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEE ENKESSSSSSEEEEGEDEASESETEKEADKKPE AFVNHSNSESKSSITEQIPAPAQNTFSASSARRF SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLS EVANSREPIRDRGSSIYRSSSSPRISALLDNKD KERENKSYISSLAPRKLNSTSDIEEKENRESAVN LVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVST YLKRTPHKSQADTTAEKTADNVSSSTPLCVITN RPLPSTANGVTATPVLSITGTDSSVEAREKRRSY LTPVRDEEAESLRKARSRQARQTRRSTQGVTLT DLQEAERTFSRSRAERQAQEQPREKPTDTEGLE GSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICH RLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWT NRFSVPDSESSETTTNTTTAKEMDKNENEEADL DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE TDGSEEVKETWHERLSRLESGGSNPTTSDSYGD RASARARREAREARLATLTSRVEEDSNRDYKKL YESALTENQKLKTKLQEAQLELADIKSKLEKVAQ QKQEKTSDRSSVLEMEKRERRALERKMSEMEEE MKVLTELKSDNQRLKDENGALIRVISKLSK*AR LQIYEERKGQHLLPPPLFSSPCLPTKRNGCFGGR TLLSITLFSHLYTLYIFSALSMPCSSKPLSQVL *QF*LKHDCGNSSHLENALGSTPGSAVDPSTSC CSATLSTLDLVQTCKTSTLISILQLFTLTQCPLI *VSLVVATPGS*LGCQEKQQDVELIIRCPLEWL ASKVTVTALRRSILLHLSGTDFYFFCQHPVISL TSFNPYSSLIPSHFSKAQMALASFIPFLSILLYF SLPHPLTQWYKS*DRAPDLSCLWPLWEVIILET RKSSLWCLGGSTTACSLEGRLWHKCQLIVFVSH LSSPFKVIFFIRKFGL*ILHSASLP*PCFPLFAL TPASNEK*SQCKEE*EVGRGDC*EMD*EVEAGW KDTYGESQVSEATCNIVTKKMEDSSLLGCENSG EFDYFQWLDLAERFTFLEINRGNGT**RFNGMKY FQPIDESHGSLEWQDPEVIRSSFLLLCHRDPCY HSFHPWAWSGSLWWLCIYYSKVGQL**RESFSS YQLKSACGFSL*SRSTICNSLTALEICAVGGLPL SLTLSCCYSSPLSHSSYGMLFLPVTSWPSSSRQ NQPLKYHVQAWKEYKSSAKLNH*FLMIT*H*YL QYFLFVGVLSLGSLECASH*ILIILGLPVIFSV* SGSFP*YILPLSVNSFLT*HVALHGPPSETPHA V*TRSCNSRSQFHQVQWLMPVIPALQEAEVDRS RGQEFETILANTVKPNLY*KYKKLARRGGRRL*S QLLRRLRQENGVNPGGGACSEP*SRHCTPAWVT EQDSISKKIIIINK*KIPITEQEICFL*QNPIF RVYKILSFISNHFSREAATILRLRIIMGVL*VQF SGNAKLE**VLYPSFWERKST*GVD*LIILEHF EYWGRKMILLSQEKKIGLLGIHLDPFPLNRPGK GVTESLLRSVCAFQKYWGQILKTLRLVLHPCHFT *PFHVKADFSCQKVFLVTRNLQAFQSQEYWIL* PRTHESKCKLS*VISGTFSYAINFIN*FLVYLQ R*NTIPSQLYCLEAP*DGNYRPSTSQQFSLDTGI SRSPFSCAAWTGTYCWPLQWPQSSVLTCWFGDS *APQAAQAE*IAADMANNMGLRSVT*LRVFT*N IRMGKRMFLVKLCFH*FVIFQKPSHTFGSNDLAI PEILGLKFVFPGLLILFQIAPEYDDPSPIPISS ERVMQISGCCL*RI*RIDMLWAYSVYQIL*WAI LI*CSLEPPCLPTAGCVYFSSGLPLVSVLVPTPS LRRLRFIYCYLRPLVRFQISLLQHFTHFPSPNH VLIRWFHSGSKEAKTQVNGLWIPRKCV*TTDCF STRGI*LSQR*WKKKLSKPCTLLGVWIFGLFAAS PSHRQTLSPLRERPVFRSRPLVSVGTLEVGME* AEEAWRRENYLKVLPVIQLPGGFAPPKVQKGKR KQKGFSI*AERKGKFYSTR*ATGSTGAYQ*SNTA GALVSFPQRYHQGPSNPIVYASTDRTLSTHLPI RGRVIGLNLGPVITTNLSHHTLSPRLECSGVIS AHCNLHLPGSRDPLTSAPEQLGLQVCTTMPS*FL NFFVEMGFCHVAQAGLKLLGSSNPPGWASQSDR ITGVRAHAQPTILIFKAGSNPS*DVSSSNPISR QL*GQKGNIKR*DPRSQNICIPRPPLLLLVM*LW AGHPPCL*NEVGLDNLYVPFPFGLKFCDLFILR KISIFIGISASKILSNLKNPSPEFFVFFWI*TV *YEHIKVDFSSFLGSEFNIEGN*MMLQWLSLLLA W*EY*SLQRWKLELMEKWIESNLLQAAFGQVVL IGNRPAAS*VSSTTFPQLS*NGIYIGSSHPNSR LIVFLLSTVWFIVLNSALQQQENFPRQEPQSLVP LSSPSGFWTYQK*EVLIPFKMVFPSKQV*RGDY QSSVYKPRVHTTILHRTALGFHKPPTGPGVIGV KGQRPWKWRWLCAAMGRRQKAQGLWT*SRVEAAS TGKEESFTETKLCHTEMSSVSLVTSSLRLQLSR DFNQLP*WVLTLLRKQ*TLSGTAIDLLCSD*IG K*INFIVVQELLVTATRNEVISEG*EKTQNLGQQ PAAAW*KMHSLLL*ELGLRANIEPRFGLQPSVP EALLRENCK*EVGVSKDNTINECSGLT*KGLAI WG*LLDLAYVRSHAHLLAQSF*NEVWHILDYK*K LRNQFYLLNHIFCFSPSLLIPQRTYLSCSPIHL LILDHESARVIFSVISPPNFSLMFPIKIYLGGP LR*HQDALMSFQNKHTLHSSPFHLPLHS*FLAFL TWSRGCFREVVFHESAKIPVEVGYTNHHHHRPL FQFQSSSAMLMSPQR*GLTFRPV*LLHSLAKET MSSHVWFTLYPETVYSLKQKCVFPAQT*SISVSV HLVATAQPIQRARIQERHTDGGEPLKSL*CSPK TRVESRSASRRGPLFLNKGHARARSSLTLA*IS VPLPVLSPTLLKPGTDSRLPSDEERLGKESLEEK RHQEAGCGVGEGSERRQQSRIPPFLASIP*TFE RLCLPLAGTPGQ*FPCRRKERMFHPCILLGEAT ACAQLSGSHSDFGFMVFLPPCLCPDLDQQG*KEP P*GFHASPILVVAFCVFTPPFTLVPPRFTHQM* LFFS*VVWINFSPL*IHLGWGGVGVV*GEAARL AL*TECIFMQF*VAFQP*DEWFCFTGCCYIVLSI LCLKVWE**YSLLYDACKHNSIYK*VNKTVF*L

Frame 1

AGGVKMAARGSPPSAPG*SALREAAAATRAPTV I*CW*FWQQLPRPEQWRNWST*EGSGQSRRECG GQSSFGAGGAR*QSRSLRSDEARGGSR*PGAGAP GSASRTVLSFWPPALAGTPTR*ESFWQEVLIST RSTWTA*QPCTRHVLMKIWTW*SFWWRTEPM*T SKTTRAGHPFMQQLPVAIST*QSISLITEPV*VL SIVKVKFPLTLQKSQP*RIFFWSK*RSKELI*S SQEKKKSSRCCRMPASGSTVGK*RM*GRLAQGL QPFMWLLPRATLKSSDF*FRLAMNSMFRIMMAGL PSMLLHTGE*RRLAPSWQKHFVTWIFEINWARH HLMWLMRVSWSIWSCSRRSRMCFEVKRRHGINS LSQI*TARFRVGSLRTKRRCSMRRRHLSPKKWRK KIKNLVAPAQRRRKVKMKLLSQKLRRRQIKSQK PLSIIPTLKARVVSQSRYQHQLKIPSLPLLLGG SLLAFLTSQKSPKMNLLLHGDWD*EKLAATTC*V RWPIPGNL*GTEALPSIAPLQALGFLLYWTTKI RREKTKAILVH*HPGSSTAQVILKKRRTENQLL I**GVAPIPGSYGGMKQKEMKSHRQLLPPPMYQL T*KGLLTNPRPTQQQRKQQTMSLLAPRSV*SPI ALFLALPMGLQLLLCSPLLEQIPLWKPGRRGGP I*LLYGMRKQSLYGKHAPDKLGRHEGLLKVSP*Q TFKKQKGHSAGRGQRGKLRSSLVRSPQTLKGLR GALRSMSPQQFQQQKLGRASSPGAGVWMKSLSV IA*GAQLSQTNPPRQHLLLRQDPHSTPVPTCYGQ IDFQSLILRVQRLPQTLQLQRKWTKMRMKKQIW MSSPLRGCPSERGGGPRNDEEAQASISGQRMRM KLMALKRSKKRGMKDFLGWNREVVILQPVILTVT GLQQEPVGRPGRPA*PP*PAV*KKTATEIIKNS MRVL*LKTKN*KQNFRKPS*S*QI*SPSLRRWP SRNKKRPLTDHQCWRWRNGRGEPWSAKCQKWRKK *RC*QN*NPTTRG*KMKMVPSSESSANCPSRLG SRFMRKERDSICCPHPSFPVLAFQPKEMDVLVE GHFFLSPSSVTSIHSTFSLHFQCPVLPNPYPKFY DSFN*SMIVVIRAIWRMLWGVHQAQLWTPQLPA AQLLCPHWIWSKHVRLLP*SVSFSFLH*PSVL* YR*VLW*PLQDPDWGAKRNSRMLN*SSDALWNG* HPR*Q*LH*GALFFFTSQELTFIFSVNTQ*SP* LVLTLIPPSYLAISPRRKWPWLHLFLSFLSFYI FPFPTPSLNGIKARTEHLTSVVFGHCGKSLFWRQ ENHHSGALVAAPLPAPWKVDYGISVSSLFSSPT YLPPSK*FSL*ENLGSEYSILPHFLDLVFLSSP *HLLLMRNEVSARRNERWGGEIVERWTRKWKQAG KTHMAKVKYLRPLATL*QRRWKIAAYWAVRIVV NLIISSG*I*QRDLLS*KLIGEMALNRGLME*S TFNPLMRVMEV*SGKTQRSLGPAFYYCVTGTPAT TAFTHGHGQVASGGYAFITQKLGNSNNERVFPH IS*SLPVDSPCSPDLLSATL*RHLRYVQWVVSP SVLL*AAVTLVL*VIPHMACFSYLSHLGHPPLDK TSL*NIMSRPGKNTNPVQN*TISS***PSINTY SIFFL*EFYPLVHLSVQVIKSSSF*GCQ*YSVF RVVHSLNIYYLCLLILS*HDM*LSMVLPLKHHML FKLEAVIQDPNSTRCSGSCL*SQHFRRPRWTDH EVRSSRPSWLTR*NPISTKNTKN*PGVVAGACS PSYSGG*GRRMA*TREAELAVSLDHATALQPG*Q SKTPSQKK****INKKSQLQNRRYVSSDKTPFL ECIKFCLSFPTIFQEKLLLS*DFVLSWEYCKFS SQGMLN*SNKFYILHSGRGNQHKVLTN*LSWNIL NIGEGR*YFFLKKRKLDY*EYILTLFHSIDQGK GLQRASSDLFVPFKSTGGRFSKLLDWCCIPATS HDPSMLKLTFLARKFSL*QEICKLFNLRNTGFYS QELMKVSVNYPR*FQVLSLMQLILLTDFWSISR DKIPFLHNCIVWKPHEMVIIGLLLASSSLWILA SAGLLFLVLLGQVPTAGLFSGHNPQSSPAGLETH EHPRQLKLNK*LQTWPTTWGSGLSLNLESLHEI SEWERECSW*NSVFINLLFFKNRATPLEVMIWP FQRFWG*SLFFQGC*SFSR*LQSMMTPAPSQSLA KGLCKSQGVASKESKE*TCFGLTQCTRFSSGPF SFDVP*NLPVFQLQDVFTSLLGFPWFLS*FPPQ V*EDLDSFIAI*GH**DFRSLFCNILPISLPQTM CLLDGSTQEARKLKLKLMVCGSHESVCKLLTVS PLEAFN*AKDDGRRNSQSHVLC*VSGFLACLQP LLATDRHCLLSEKGQCFGPGHW*VSAPLRWAWSE QKKPGEERTI*KCCQLFSFQAALHLQRCKKEKE SRKDSAFKQKEKGNSTLPDEPLVPLELISEVTL QEPWYPSLRDIIRGPQTPLFMPALTAL*AHTYQS EVV*LA*I*AQLLLQILVTILSRPGWSAVV*SQ LTATSTSQAQGILSPQLPSS*DCRCAPPCPANF *IFL*RWGFAMLPRLV*SCWAQAIHLAGPPKAIG LQA*GPTPSLPY*FSRQGLTLHKM*VLPTQ*AG SFEDKKATLKDKTLEVRTSVFQGHPFSF*SCDF GQVTLPVCKMRLDWIIFMCPFLLA*NSVIYSFLG RSAYLLGFLLQKFFLTSKIQVQNFLFSSGFKLF NMSTSRLTSHPFWEVNLILRVIE*CCNGFPSCW LGKNIKACRGGNWSSWRNG*KAICCRQPLDKLF* *EIDLLLHRFPQPPFLSFLKMGSTLALHTQIAD *SFFCLAPSGSLS*TLPYSSKKIFLDKNLNL*F H*APPLDFGLTRSRRF*YHSRWSFLQSRSEEETT KAVFTNPESTQPYCIEQHLAFTSLLQDLV*LE* KGRDPGSGGGCVLRWEEGRRPRGFGHRAGWKLQ VLGRKRVSQKQSFVTQK*VLSHW*LHPSGSS*AE ILISFLNGY*HCSGSSRPCQGQLLIFCVLIRLE NRSTSL*SRNCWSQLLGMR*FLRAEKKHRILAS SQQLHGERCIHFSFESWG*GQT*NPGLAYNPVSR KPSFGRTVSKRWVCLKTIPLMNVLALPKKV*QF GDNSWI*LMCVHMHIC*PRAFKMRSGIYLITNE NSETNFIY*IISFVFPPPF*SPKGPI*AVPQFIC LFWTMNLPE*YFLLFLLQIFP*CFQ*RFTWVAP *GDIRMLLCPSRISIHFTPLPFISLCILNSLLF SLGAEGALERWFSMNQPRFL*KLGIPTTTTTAPY SSFKAPRLC*CPLRDEV*LLGPYDSSIAWPRRP *VAMSGLLFILRLFIA*NRSVSSQHKPNQSVYQ CIWWQQLSPFKEQGFRKGTLMVGSLLRASNVLPK PELRVGVPVVGAHYS*IRDMQGPEVA*LSPKYL CLCLSFLPLY*NPEQIPACLLMKRG*VKRVWRK KDTRRQAAG*ERVLRGGSNPEYLLF*PASLELLK GCAYHWLAHQGNDFPAEGRKECFTLASFLEKLQ PVLS*VVHTQTLALWFSFLLVFALTLINRGEKN HPEVSMPLPF*W*HFVSLLHPSP*FHQGSHTRCN CFSAELYGLTSVHCKYTWDGVGLGLFREKQPDL LCELNVFLCNFEWPFNPKMNGFVLLVVVI*F*V FCV*KFGNNNIHFYMMPVNTTVFINE*IKLCFNF

Frame 2

REE*RWRREGLRPLLRAEAL*ERRQRQLEPQQ* FSVGSFGSSCRGRSNGGTGAPRREAGRVGANAA GRAASALAGLADRAGACGATRRGAAAADQAREP QGPLRGRCCLSGRLL*RGHRRGEKASGKRC*YQH GQRGRLDSPAPGMY**KFGHGEVSGGEQSQCKP ARQRGLDTPSCSSFLWLSQHSRVFH*SRSQCRY CQ**R*SSL*PCRRASHEGSSSGASKEARS*SRA VKKRRRAADVAGCPPVAQQWENRGCEAGSLRGY SPSCGCCQGLL*SPQTFNSGWL*TQCSGL*WLD SPPCCCTLGSEGGLLHPGRSTL*HGYSK*TGPDT I*CG**GSRGAFGVAPEEAECASK*KGDTE*TH *VRSEQQDSEWVL*EQREDAL*GGDT*VPRNGG RK*RI**LQLRGGGR*R*SF*VRN*EGGR*KARS LCQSFQL*KQE*YHRADTSTSSKYLLCLFC*EV LFWPF*QARRAQR*ISFFMEIGTEKNWQPQHAE *GGQFQGTYKGPRLFHLSLLFKPSDFCSTGQQR* GERKQKLY*FTSTPEAQQHK*Y*RKGEQRISC* SSEEWLLYPAAMEG*SKRK*NPTDNCSLHLCIN LLEKDSSQIPGRHNSRENSRQCLF*HPALCDHQS PSS*HCQWGYSYSCALHYWNRFLCGSQGEEEVL SDSCTG*GSRVFTESTLQTSSADTKVYSRCHPN RPSRSRKDIQPVEGREASSGAAS*EAHRH*RA*G EP*EA*ALSSSSNRSWGGPAALGQESG*RAYLS SPEVPSSARQTHHASISFYVKTLTLHQFPPAMD K*IFSP*F*EFRDYHKHYNCKGNGQK*E*RSRFG *AVL*EAVHPREEAAQGTTKRHRHQFLDKG*G* N*WL*RGQRNVA*KTF*VGIGR**SYNQ*FLR* PGFSKSPSGGPGGPPSHPDQPCRRRQQQRL*KTL *ECSD*KPKTENKTSGSPARASRYKVQA*EGGP AETRKDL*PIISAGDGETGEASLGAQNVRNGGR NEGVNRTEIRQPEAER*KWCPHQSHQQTVQVG*A PDL*GKKGTAFAAPTPLFQSLPSNQKKWMFWWK DTSFYHPLQSPLYTLHFLCTFNALFFQTPIPSF MTVLIEA*LW*FEPSGECSGEYTRLSCGPLNFLL LSYFVHIGFGPNM*DFYPNQYPSAFYINPVSSD IGESCGSHSRILIGVPRETAGC*IDHQMPSGMV SIQGDSDCIEALYSSSPLRN*LLFFLSTPSNLPN *F*PLFLPHT*PFLQGANGPGFIYSFPFYPFIF FPSPPPHSMV*KLGQST*PQLSLAIVGSHYSGD KKIITLVPWWQHHCLLPGR*TMA*VSAHCFRLPL IFPLQSDFLYKKIWALNTPFCLTSLTLFSSLRP DTCF**EMKSVQGGMRGGEGRLLRDGLGSGSRL ERHIWRKSSI*GHLQHCDKEDGR*QPTGL*E*W* I*LFPVVRFSREIYFLRN**GKWHLIEV*WNEV LSTH**ESWKFRVARPRGH*VQLSIIVSQGPLL PQLSPMGMVR*PLVAMHLLLKSWATLITREFFLI SAEVCLWILLVVQIYYLQLFNGT*DMCSGWSPP QSYFELLLL*SFKSFLIWHAFLTCHILAILL*T KPAFKISCPGLERIQIQCKIKPLVLDDNLALILT VFSFCRSFIPWFT*VCKSLNPHHFRVASDIQCL EWFIPLIYTTSVC*FFPNMTCSSPWSSL*NTTC CLN*KL*FKIPIPPGAVAHACNPSTSGGRGGQIT RSGVRDHPG*HGETQSLLKIQKISQAWWQAPVV PATQEAEAGEWREPGRRSLQ*ALITPLHSSLGD RARLHLKKNNNNK*IKNPNYRTGDMFPLTKPHF* SV*NSVFHFQPFFKRSCYYLETSYYHGSTVSSV LREC*IRVISFISFILGEEINIRC*LIDYPGTF *ILGKEDDTSFSRKENWIIRNTS*PFSTQ*TRER GYREPPQICLCLSKVLGADSQNS*IGVASLPLH MTLPC*S*LFLPESFPCDKKFASFSISGILDSI AKNS*K*V*TILGNFRYFLLCN*FY*LISGLSPE IKYHSFTTVLSGSPMRW*L*AFY*PAVLSGYWH QQVSFFLCCLDRYLLLASSVATILSPHLLVWRL MSTPGSSS*INSCRHGQQHGAQVCHLT*SLYMKY QNGKENVPGKTLFSLICYFSKTEPHLWK**FGH SRDSGAKVCFSRAADPFPDSSRV**PQPHPNL* RKGYANLRVLPLKNLKNRHALGLLSVPDSLVGHS HLMFPRTSLSSNCRMCLLLFWASPGFCPSSHPK FKKT*IHLLLSEATSEISDLSFATFYPFPFPKP CAY*MVPLRKQGS*NSS*WSVDPTKVCVNY*LFL H*RHLIEPKMMEEETLKAMYFVRCLDFWPVCSL S*PQTDTVSSQRKASVSVQATGECRHP*GGHGV SRRSLEKRELFKSVASYSASRRLCTSKGAKRKKK AERIQHLSRKKREILLYQMSHWFHWSLSVK*HC RSPGILPSEISSGALKPHCLCQH*PHFKHTLTN QRSCNWPKSRPSYYYKS*SPYSLAQAGVQWCDLS SLQPPPPRLKGSSHLSSRAARTAGVHHHAQLIF EFFCRDGVLPCCPGWSEAAGLKQSTWLGLPKR* DYRRKGPRPAYHTDFQGRV*PFIRCEFFQPNKQA ALRTKRQH*KIRP*KSEHLYSKATPSPFSHVTL GRSPSLSVK*GWTG*SLCALSFWLKIL*FIHS* EDQHIYWDFCFKNSF*PQKSKSRIFCFLLDLNCL I*AHQG*LLILFGK*I*Y*G*LNDVAMAFPPAG LVRILKPAEVEIGAHGEMDRKQFVAGSLWTSCF NRK*TCCFIGFLNHLSSAFLKWDLHWLFTPK*QT NRFSA*HRLVHCLELCLTAARKFSSTRTSIFSS IELPLWILDLPEVGGSDTIQDGLSFKAGLKRRL PKQCLQTQSPHNHIA*NSTWLSQASYRTWCNWSE RAETLEVEVAVCCDGKKAEGPGALDIEQGGSCK YWEGREFHRNKALSHRNEFCLTGDFIPQAPAEQ RF*SASLMGIDTAQEAVDPVRDSY*SFVF*LDWK IDQLHCSPGTVGHSY*E*GDF*GLRKNTESWPA ASSCMVKDAFTSPLRVGVEGKHRTQVWLTTQCP GSPPSGEL*VRGGCV*RQYH**MFWPYLKRFSNL GITLGSSLCAFTCTFASPELLK*GLAYT*LQMK TQKPILFIKSYLLFFPLPSNPPKDLFELFPNSS AYFGP*ICQSDIFCYFSSKFFPDVSNKDLLGWPL KVTSGCSYVLPE*AYTSLLSLSSPSAFLIPCFS HLEPRVL*RGGFP*ISQDSCRSWVYQPPPPPPP IPVSKLLGYANVPSEMRFDF*ARMTPP*PGQGDH E*PCLVYSLS*DCL*LKTEVCLPSTNLINQCIS ASGGNSSAHSKSKDSGKAH*WWGAS*EPLMFSQ NQS*ESECQSSGPTIPE*GTCKGQK*LDSRLNIC AFACPFSHSTETRNRFPLAF**REVR*REFGGK KTPGGRLRGRRGF*EEAAIQNTSFSSQHPLNF* KVVPTTGWHTRAMISLQKEGKNVSPLHPSWRSYS LCSVEWFTLRLWLYGFPSSLSLP*P*STGVKRT TLRFPCLSHFSGSILCLYSTLHPSSTKVHTPDV TVFQLSCMD*LQSTVNTPGMGWGWGCLGRSSQTC FVN*MYFYAILSGLSTLR*MVLFYWLLLYSFEY SVFESLGIIIFTSI*CL*TQQYL*MSK*NCVLT L

Sequence NM_032103

GTTGCTGGTACAATCTCATAAAATGGGCTCCAGTGTTTAGAGAAGGACAGTCAGAGGAGTGGCCACCTGTTTGTTGAAAATTGGGCTTCTGGGAAAGTTG CTGCACAAGTGTGTGGCAAGGTGTGTCTGAGATAGCTTGACCTGCTTTCACCTGGAATGATTTGATCTGGCAATAGAGTTCCTTGCCATTCCTGGTTTTA TGGAAATCAGAGGCACAGGAAGTTGATCTGGGTGTTCTGGGGAATTGAGACAAGCCTCTGCCATAGTTTGTTAGTACTCTGTGTTTGGATGCTAACTCCA GTGTGCTGAGTTGAGACATCAGCAAGTGCTGGGCCTGGAATGTCAGAAGCAGCAGGTCCTATCTGACTCCTGTACGGGATGAGGAAGCAGAGTCTTTACG GAAAGCACGCTCCAGACAAGCTCGGCAGACACGAAGGTCTACTCAAGGTGTCACCCTAACAGACCTTCAAGAAGCAGAAAGGACATTCAGCCGGTCGAGG GCAGAGAGGCAAGCTCAGGAGCAGCCTCGTGAGAAGCCCACAGACACTGAAGGGCTTGAGGGGAGCCCTGAGAAGCATGAGCCCTCAGCAGTTCCAGCAA CAGAAGCTGGGGAGGGCCAGCAGCCCTGGGGCAGGAGTCTGGATGAAGAGCCTATCTGTCATCGCCTGAGGTGCCCAGCTCAGCCAGACAAACCCACCAC GCCAGCATCTCCTTCTACGTCAAGACCCTCACTCTACACCAGTTCCCACCTGCTATGGACAAATAGATTTTCAGTCCCTGATTCTGAGAGTTCAGAGACT ACCACAAACACTACAACTGCAAAGGAAATGGACAAAAATGAGAATGAAGAAGCAGATTTGGATGAGCAGTCCTCTAAGAGGCTGTCCATCCGAGAGAGGA GGCGGCCCAAGGAACGACGAAGAGGCACAGGCATCAATTTCTGGACAAAGGATGAGGATGAAACTGATGGCTCTGAAGAGGTCAAAGAAACGTGGCATGA AAGACTTTCTAGGTTGGAATCGGGAGGTAGTAATCCTACAACCAGTGATTCTTACGGTGACCGGGCTTCAGCAAGAGCCCGTCGGGAGGCCCGGGAGGCC CGCCTAGCCACCCTGACCAGCCGTGTAGAAGAAGACAGCAACAGAGATTATAAAAAACTCTATGAGAGTGCTCTGACTGAAAACCAAAAACTGAAAACAA AACTTCAGGAAGCCCAGCTAGAGCTAGCAGATATAAAGTCCAAGCTTGAGAAGGTGGCCCAGCAGAAACAAGAAAAGACCTCTGACCGATCATCAGTGCT GGAGATGGAGAAACGGGAGAGGCGAGCCTTGGAGCGCAAAATGTCAGAAATGGAGGAAGAAATGAAGGTGTTAACAGAACTGAAATCCGACAACCAGAGG CTGAAAGATGAAAATGGTGCCCTCATCAGAGTCATCAGCAAACTGTCCAAGTAGGCTAGGCTCCAGATTTATGAGGAAAGAAAGGGACAGCATTTGCTGC CCCCACCCCTCTTTTCCAGTCCTTGCCTTCCAACCAAAAGAAATGGATGTTTTGGTGGAAGGACACTTCTTTCTATCACCCTCTTCAGTCACCTCTATAC ACTCTACATTTTCTCTGCACTTTCAATGCCCTGTTCTTCCAAACCCCTATCCCAAGTTTTATGACAGTTTTAATTGAAGCATGATTGTGGTAATTCGAGC CATCTGGAGAATGCTCTGGGGAGTACACCAGGCTCAGCTGTGGACCCCTCAACTTCCTGCTGCTCAGCTACTTTGTCCACATTGGATTTGGTCCAAACAT GTAAGACTTCTACCCTAATCAGTATCCTTCAGCTTTTTACATTAACCCAGTGTCCTCTGATATAGGTGAGTCTTGTGGTAGCCACTCCAGGATCCTGATT GGGGTGCCAAGAGAAACAGCAGGATGTTGAATTGATCATCAGATGCCCTCTGGAATGGTTAGCATCCAAGGTGACAGTGACTGCATTGAGGCGCTCTATT CTTCTTCACCTCTCAGGAACTGACTTTTATTTTTTCTGTCAACACCCAGTAATCTCCCTAACTAGTTTTAACCCTTATTCCTCCCTCATACCTAGCCATT TCTCCAAGGCGCAAATGGCCCTGGCTTCATTTATTCCTTTCCTTTCTATCCTTTTATATTTTTCCCTTCCCCACCCCCTCACTCAATGGTATAAAAGCTA GGACAGAGCACCTGACCTCAGTTGTCTTTGGCCATTGTGGGAAGTCATTATTCTGGAGACAAGAAAATCATCACTCTGGTGCCTTGGTGGCAGCACCACT GCCTGCTCCCTGGAAGGTAGACTATGGCATAAGTGTCAGCTCATTGTTTTCGTCTCCCACTTATCTTCCCCCTTCAAAGTGATTTTCTTTATAAGAAAAT TTGGGCTCTGAATACTCCATTCTGCCTCACTTCCTTGACCTTGTTTTCCTCTCTTCGCCCTGACACCTGCTTCTAATGAGAAATGAAGTCAGTGCAAGGA GGAATGAGAGGTGGGGAGGGGAGATTGTTGAGAGATGGACTAGGAAGTGGAAGCAGGCTGGAAAGACACATATGGCGAAAGTCAAGTATCTGAGGCCACT TGCAACATTGTGACAAAGAAGATGGAAGATAGCAGCCTACTGGGCTGTGAGAATAGTGGTGAATTTGATTATTTCCAGTGGTTAGATTTAGCAGAGAGAT TTACTTTCTTAGAAATTAATAGGGGAAATGGCACTTAATAGAGGTTTAATGGAATGAAGTACTTTCAACCCATTGATGAGAGTCATGGAAGTTTAGAGTG GCAAGACCCAGAGGTCATTAGGTCCAGCTTTCTATTATTGTGTCACAGGGACCCCTGCTACCACAGCTTTCACCCATGGGCATGGTCAGGTAGCCTCTGG TGGCTATGCATTTATTACTCAAAAGTTGGGCAACTCTAATAACGAGAGAGTTTTTCCTCATATCAGCTGAAGTCTGCCTGTGGATTCTCCTTGTAGTCCA GATCTACTATCTGCAACTCTTTAACGGCACTTGAGATATGTGCAGTGGGTGGTCTCCCCCTCAGTCTTACTTTGAGCTGCTGTTACTCTAGTCCTTTAAG TCATTCCTCATATGGCATGCTTTTCTTACCTGTCACATCTTGGCCATCCTCCTCTAGACAAAACCAGCCTTTAAAATATCATGTCCAGGCCTGGAAAGAA TACAAATCCAGTGCAAAATTAAACCATTAGTTCTTGATGATAACCTAGCATTAATACTTACAGTATTTTCTTTTTGTAGGAGTTTTATCCCTTGGTTCAC TTGAGTGTGCAAGTCATTAAATCCTCATCATTTTAGGGTTGCCAGTGATATTCAGTGTTTAGAGTGGTTCATTCCCTTAATATATACTACCTCTGTCTGT TAATTCTTTCCTAACATGACATGTAGCTCTCCATGGTCCTCCCTCTGAAACACCACATGCTGTTTAAACTAGAAGCTGTAATTCAAGATCCCAATTCCAC CAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTCAGGAGGCCGAGGTGGACAGATCACGAGGTCAGGAGTTCGAGACCATCCTGGCTAACACGGTGA AACCCAATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAA CCCGGGAGGCGGAGCTTGCAGTGAGCCTTGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAATAATAATAATAAAT AAATAAAAAATCCCAATTACAGAACAGGAGATATGTTTCCTCTGACAAAACCCCATTTTTAGAGTGTATAAAATTCTGTCTTTCATTTCCAACCATTTTT CAAGAGAAGCTGCTACTATCTTGAGACTTCGTATTATCATGGGAGTACTGTAAGTTCAGTTCTCAGGGAATGCTAAATTAGAGTAATAAGTTTTATATCC TTCATTCTGGGAGAGGAAATCAACATAAGGTGTTGACTAATTGATTATCCTGGAACATTTTGAATATTGGGGAAGGAAGATGATACTTCTTTCTCAAGAA AAGAAAATTGGATTATTAGGAATACATCTTGACCCTTTTCCACTCAATAGACCAGGGAAAGGGGTTACAGAGAGCCTCCTCAGATCTGTTTGTGCCTTTC AAAAGTACTGGGGGCAGATTCTCAAAACTCTTAGATTGGTGTTGCATCCCTGCCACTTCACATGACCCTTCCATGTTAAAGCTGACTTTTCTTGCCAGAA AGTTTTCCTTGTGACAAGAAATTTGCAAGCTTTTCAATCTCAGGAATACTGGATTCTATAGCCAAGAACTCATGAAAGTAAGTGTAAACTATCCTAGGTA ATTTCAGGTACTTTCTCTTATGCAATTAATTTTATTAACTGATTTCTGGTCTATCTCCAGAGATAAAATACCATTCCTTCACAACTGTATTGTCTGGAAG CCCCATGAGATGGTAATTATAGGCCTTCTACTAGCCAGCAGTTCTCTCTGGATACTGGCATCAGCAGGTCTCCTTTTTCTTGTGCTGCTTGGACAGGTAC CTACTGCTGGCCTCTTCAGTGGCCACAATCCTCAGTCCTCACCTGCTGGTTTGGAGACTCATGAGCACCCCAGGCAGCTCAAGCTGAATAAATAGCTGCA GACATGGCCAACAACATGGGGCTCAGGTCTGTCACTTAACTTAGAGTCTTTACATGAAATATCAGAATGGGAAAGAGAATGTTCCTGGTAAAACTCTGTT TTCATTAATTTGTTATTTTTCAAAAACCGAGCCACACCTTTGGAAGTAATGATTTGGCCATTCCAGAGATTCTGGGGCTAAAGTTTGTTTTTCCAGGGCT GCTGATCCTTTTCCAGATAGCTCCAGAGTATGATGACCCCAGCCCCATCCCAATCTCTAGCGAAAGGGTTATGCAAATCTCAGGGTGTTGCCTCTAAAGA ATCTAAAGAATAGACATGCTTTGGGCTTACTCAGTGTACCAGATTCTCTAGTGGGCCATTCTCATTTGATGTTCCCTAGAACCTCCCTGTCTTCCAACTG CAGGATGTGTTTACTTCTCTTCTGGGCTTCCCCTGGTTTCTGTCCTAGTTCCCACCCCAAGTTTAAGAAGACTTAGATTCATTTATTGCTATCTGAGGCC ACTAGTGAGATTTCAGATCTCTCTTTTGCAACATTTTACCCATTTCCCTTCCCCAAACCATGTGCTTATTAGATGGTTCCACTCAGGAAGCAAGGAAGCT AAAACTCAAGTTAATGGTCTGTGGATCCCACGAAAGTGTGTGTAAACTACTGACTGTTTCTCCACTAGAGGCATTTAATTGAGCCAAAGATGATGGAAGA AGAAACTCTCAAAGCCATGTACTTTGTTAGGTGTCTGGATTTTTGGCCTGTTTGCAGCCTCTCCTAGCCACAGACAGACACTGTCTCCTCTCAGAGAAAG GCCAGTGTTTCGGTCCAGGCCACTGGTGAGTGTCGGCACCCTTGAGGTGGGCATGGAGTGAGCAGAAGAAGCCTGGAGAAGAGAGAACTATTTAAAAGTG TTGCCAGTTATTCAGCTTCCAGGCGGCTTTGCACCTCCAAAGGTGCAAAAAGGAAAAAGAAAGCAGAAAGGATTCAGCATTTAAGCAGAAAGAAAAGGGA AATTCTACTCTACCAGATGAGCCACTGGTTCCACTGGAGCTTATCAGTGAAGTAACACTGCAGGAGCCCTGGTATCCTTCCCTCAGAGATATCATCAGGG GCCCTCAAACCCCATTGTTTATGCCAGCACTGACCGCACTTTAAGCACACACTTACCAATCAGAGGTCGTGTAATTGGCCTAAATCTAGGCCCAGTTATT ACTACAAATCTTAGTCACCATACTCTCTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGGGATCCTC TCACCTCAGCTCCCGAGCAGCTAGGACTGCAGGTGTGCACCACCATGCCCAGCTAATTTTTGAATTTTTTTGTAGAGATGGGGTTTTGCCATGTTGCCCA GGCTGGTCTGAAGCTGCTGGGCTCAAGCAATCCACCTGGCTGGGCCTCCCAAAGCGATAGGATTACAGGCGTAAGGGCCCACGCCCAGCCTACCATACTG ATTTTCAAGGCAGGGTCTAACCCTTCATAAGATGTGAGTTCTTCCAACCCAATAAGCAGGCAGCTTTGAGGACAAAAAGGCAACATTAAAAGATAAGACC CTAGAAGTCAGAACATCTGTATTCCAAGGCCACCCCTTCTCCTTTTAGTCATGTGACTTTGGGCAGGTCACCCTCCCTGTCTGTAAAATGAGGTTGGACT GGATAATCTTTATGTGCCCTTTCCTTTTGGCTTAAAATTCTGTGATTTATTCATTCTTAGGAAGATCAGCATATTTATTGGGATTTCTGCTTCAAAAATT CTTTCTAACCTCAAAAATCCAAGTCCAGAATTTTTTGTTTTCTTCTGGATTTAAACTGTTTAATATGAGCACATCAAGGTTGACTTCTCATCCTTTTTGG GAAGTGAATTTAATATTGAGGGTAATTGAATGATGTTGCAATGGCTTTCCCTCCTGCTGGCTTGGTAAGAATATTAAAGCCTGCAGAGGTGGAAATTGGA GCTCATGGAGAAATGGATAGAAAGCAATTTGTTGCAGGCAGCCTTTGGACAAGTTGTTTTAATAGGAAATAGACCTGCTGCTTCATAGGTTTCCTCAACC ACCTTTCCTCAGCTTTCTTAAAATGGGATCTACATTGGCTCTTCACACCCAAATAGCAGACTAATCGTTTTTCTGCTTAGCACCGTCTGGTTCATTGTCT TGAACTCTGCCTTACAGCAGCAAGAAAATTTTCCTCGACAAGAACCTCAATCTTTAGTTCCATTGAGCTCCCCCTCTGGATTTTGGACTTACCAGAAGTA GGAGGTTCTGATACCATTCAAGATGGTCTTTCCTTCAAAGCAGGTCTGAAGAGGAGACTACCAAAGCAGTGTTTACAAACCCAGAGTCCACACAACCATA TTGCATAGAACAGCACTTGGCTTTCACAAGCCTCCTACAGGACCTGGTGTAATTGGAGTGAAAGGGCAGAGACCCTGGAAGTGGAGGTGGCTGTGTGCTG CGATGGGAAGAAGGCAGAAGGCCCAGGGGCTTTGGACATAGAGCAGGGTGGAAGCTGCAAGTACTGGGAAGGAAGAGAGTTTCACAGAAACAAAGCTTTG TCACACAGAAATGAGTTCTGTCTCACTGGTGACTTCATCCCTCAGGCTCCAGCTGAGCAGAGATTTTAATCAGCTTCCTTAATGGGTATTGACACTGCTC AGGAAGCAGTAGACCCTGTCAGGGACAGCTATTGATCTTTTGTGTTCTGATTAGATTGGAAAATAGATCAACTTCATTGTAGTCCAGGAACTGTTGGTCA CAGCTACTAGGAATGAGGTGATTTCTGAGGGCTGAGAAAAAACACAGAATCTTGGCCAGCAGCCAGCAGCTGCATGGTGAAAGATGCATTCACTTCTCCT TTGAGAGTTGGGGTTGAGGGCAAACATAGAACCCAGGTTTGGCTTACAACCCAGTGTCCCGGAAGCCCTCCTTCGGGAGAACTGTAAGTAAGAGGTGGGT GTGTCTAAAGACAATACCATTAATGAATGTTCTGGCCTTACCTAAAAAGGTTTAGCAATTTGGGGATAACTCTTGGATCTAGCTTATGTGCGTTCACATG CACATTTGCTAGCCCAGAGCTTTTAAAATGAGGTCTGGCATATACTTGATTACAAATGAAAACTCAGAAACCAATTTTATTTATTAAATCATATCTTTTG TTTTTCCCCCTCCCTTCTAATCCCCCAAAGGACCTATTTGAGCTGTTCCCCAATTCATCTGCTTATTTTGGACCATGAATCTGCCAGAGTGATATTTTCT GTTATTTCTCCTCCAAATTTTTCCCTGATGTTTCCAATAAAGATTTACTTGGGTGGCCCCTTAAGGTGACATCAGGATGCTCTTATGTCCTTCCAGAATA AGCATACACTTCACTCCTCTCCCTTTCATCTCCCTCTGCATTCTTAATTCCTTGCTTTTCTCACTTGGAGCCGAGGGTGCTTTAGAGAGGTGGTTTTCCA TGAATCAGCCAAGATTCCTGTAGAAGTTGGGTATACCAACCACCACCACCACCGCCCCCTATTCCAGTTTCAAAGCTCCTCGGCTATGCTAATGTCCCCT CAGAGATGAGGTTTGACTTTTAGGCCCGTATGACTCCTCCATAGCCTGGCCAAGGAGACCATGAGTAGCCATGTCTGGTTTACTCTTTATCCTGAGACTG TTTATAGCTTAAAACAGAAGTGTGTCTTCCCAGCACAAACCTAATCAATCAGTGTATCAGTGCATCTGGTGGCAACAGCTCAGCCCATTCAAAGAGCAAG GATTCAGGAAAGGCACACTGATGGTGGGGAGCCTCTTAAGAGCCTCTAATGTTCTCCCAAAACCAGAGTTGAGAGTCGGAGTGCCAGTCGTCGGGGCCCA CTATTCCTGAATAAGGGACATGCAAGGGCCAGAAGTAGCTTGACTCTCGCCTAAATATCTGTGCCTTTGCCTGTCCTTTCTCCCACTCTACTGAAACCCG GAACAGATTCCCGCTTGCCTTCTGATGAAGAGAGGTTAGGTAAAGAGAGTTTGGAGGAAAAAAGACACCAGGAGGCAGGCTGCGGGGTAGGAGAGGGTTC TGAGAGGAGGCAGCAATCCAGAATACCTCCTTTTCTAGCCAGCATCCCTTGAACTTTTGAAAGGTTGTGCCTACCACTGGCTGGCACACCAGGGCAATGA TTTCCCTGCAGAAGGAAGGAAAGAATGTTTCACCCTTGCATCCTTCTTGGAGAAGCTACAGCCTGTGCTCAGTTGAGTGGTTCACACTCAGACTTTGGCT TTATGGTTTTCCTTCCTCCTTGTCTTTGCCCTGACCTTGATCAACAGGGGTGAAAAGAACCACCCTGAGGTTTCCATGCCTCTCCCATTTTAGTGGTAGC ATTTTGTGTCTTTACTCCACCCTTCACCCTAGTTCCACCAAGGTTCACACACCAGATGTAACTGTTTTTCAGCTGAGTTGTATGGATTAACTTCAGTCCA CTGTAAATACACCTGGGATGGGGTGGGGTTGGGGTTGTTTAGGGAGAAGCAGCCAGACTTGCTTTGTGAACTGAATGTATTTTTATGCAATTTTGAGTGG CCTTTCAACCCTAAGATGAATGGTTTTGTTTTACTGGTTGTTGTTATATAGTTTTGAGTATTCTGTGTTTGAAAGTTTGGGAATAATAATATTCACTTCT ATATGATGCCTGTAAACACAACAGTATTTATAAATGAGTAAATAAAACTGTGTTTTAACTTTG

refseq_PPP1R12B.F1 (forward primer)
refseq_PPP1R12B.R1 (reverse primer)
Single exon skipping

Frame 0

VAGTIS*NGLQCLEKDSQRSGHLFVENWASGKV AAQVCGKVCLR*LDLLSPGMI*SGNRVPCHSWFY GNQRHRKLIWVFWGIETSLCHSLLVLCVWMLTP VC*VETSASAGPGMSEAAGPI*LLYGMRKQSLY GKHAPDKLGRHEGLLKVSP*QTFKKQKGHSAGRG QRGKLRSSLVRSPQTLKGLRGALRSMSPQQFQQ QKLGRASSPGAGVWMKSLSVIA*GAQLSQTNPP RQHLLLRQDPHSTPVPTCYGQIDFQSLILRVQRL PQTLQLQRKWTKMRMKKQIWMSSPLRGCPSERG GGPRNDEEAQASISGQRMRMKLMALKRSKKRGM KDFLGWNREVVILQPVILTVTGLQQEPVGRPGRP A*PP*PAV*KKTATEIIKNSMRVL*LKTKN*KQ NFRKPS*S*QI*SPSLRRWPSRNKKRPLTDHQC WRWRNGRGEPWSAKCQKWRKK*RC*QN*NPTTRG *KMKMVPSSESSANCPSRLGSRFMRKERDSICC PHPSFPVLAFQPKEMDVLVEGHFFLSPSSVTSI HSTFSLHFQCPVLPNPYPKFYDSFN*SMIVVIRA IWRMLWGVHQAQLWTPQLPAAQLLCPHWIWSKH VRLLP*SVSFSFLH*PSVL*YR*VLW*PLQDPD WGAKRNSRMLN*SSDALWNG*HPR*Q*LH*GALF FFTSQELTFIFSVNTQ*SP*LVLTLIPPSYLAI SPRRKWPWLHLFLSFLSFYIFPFPTPSLNGIKA RTEHLTSVVFGHCGKSLFWRQENHHSGALVAAPL PAPWKVDYGISVSSLFSSPTYLPPSK*FSL*EN LGSEYSILPHFLDLVFLSSP*HLLLMRNEVSAR RNERWGGEIVERWTRKWKQAGKTHMAKVKYLRPL ATL*QRRWKIAAYWAVRIVVNLIISSG*I*QRD LLS*KLIGEMALNRGLME*STFNPLMRVMEV*S GKTQRSLGPAFYYCVTGTPATTAFTHGHGQVASG GYAFITQKLGNSNNERVFPHIS*SLPVDSPCSP DLLSATL*RHLRYVQWVVSPSVLL*AAVTLVL* VIPHMACFSYLSHLGHPPLDKTSL*NIMSRPGKN TNPVQN*TISS***PSINTYSIFFL*EFYPLVH LSVQVIKSSSF*GCQ*YSVFRVVHSLNIYYLCL LILS*HDM*LSMVLPLKHHMLFKLEAVIQDPNST RCSGSCL*SQHFRRPRWTDHEVRSSRPSWLTR* NPISTKNTKN*PGVVAGACSPSYSGG*GRRMA* TREAELAVSLDHATALQPG*QSKTPSQKK****I NKKSQLQNRRYVSSDKTPFLECIKFCLSFPTIF QEKLLLS*DFVLSWEYCKFSSQGMLN*SNKFYI LHSGRGNQHKVLTN*LSWNILNIGEGR*YFFLKK RKLDY*EYILTLFHSIDQGKGLQRASSDLFVPF KSTGGRFSKLLDWCCIPATSHDPSMLKLTFLAR KFSL*QEICKLFNLRNTGFYSQELMKVSVNYPR* FQVLSLMQLILLTDFWSISRDKIPFLHNCIVWK PHEMVIIGLLLASSSLWILASAGLLFLVLLGQV PTAGLFSGHNPQSSPAGLETHEHPRQLKLNK*LQ TWPTTWGSGLSLNLESLHEISEWERECSW*NSV FINLLFFKNRATPLEVMIWPFQRFWG*SLFFQG C*SFSR*LQSMMTPAPSQSLAKGLCKSQGVASKE SKE*TCFGLTQCTRFSSGPFSFDVP*NLPVFQL QDVFTSLLGFPWFLS*FPPQV*EDLDSFIAI*G H**DFRSLFCNILPISLPQTMCLLDGSTQEARKL KLKLMVCGSHESVCKLLTVSPLEAFN*AKDDGR RNSQSHVLC*VSGFLACLQPLLATDRHCLLSEK GQCFGPGHW*VSAPLRWAWSEQKKPGEERTI*KC CQLFSFQAALHLQRCKKEKESRKDSAFKQKEKG NSTLPDEPLVPLELISEVTLQEPWYPSLRDIIR GPQTPLFMPALTAL*AHTYQSEVV*LA*I*AQLL LQILVTILSRPGWSAVV*SQLTATSTSQAQGIL SPQLPSS*DCRCAPPCPANF*IFL*RWGFAMLP RLV*SCWAQAIHLAGPPKAIGLQA*GPTPSLPY* FSRQGLTLHKM*VLPTQ*AGSFEDKKATLKDKT LEVRTSVFQGHPFSF*SCDFGQVTLPVCKMRLD WIIFMCPFLLA*NSVIYSFLGRSAYLLGFLLQKF FLTSKIQVQNFLFSSGFKLFNMSTSRLTSHPFW EVNLILRVIE*CCNGFPSCWLGKNIKACRGGNW SSWRNG*KAICCRQPLDKLF**EIDLLLHRFPQP PFLSFLKMGSTLALHTQIAD*SFFCLAPSGSLS *TLPYSSKKIFLDKNLNL*FH*APPLDFGLTRS RRF*YHSRWSFLQSRSEEETTKAVFTNPESTQPY CIEQHLAFTSLLQDLV*LE*KGRDPGSGGGCVL RWEEGRRPRGFGHRAGWKLQVLGRKRVSQKQSF VTQK*VLSHW*LHPSGSS*AEILISFLNGY*HCS GSSRPCQGQLLIFCVLIRLENRSTSL*SRNCWS QLLGMR*FLRAEKKHRILASSQQLHGERCIHFS FESWG*GQT*NPGLAYNPVSRKPSFGRTVSKRWV CLKTIPLMNVLALPKKV*QFGDNSWI*LMCVHM HIC*PRAFKMRSGIYLITNENSETNFIY*IISF VFPPPF*SPKGPI*AVPQFICLFWTMNLPE*YFL LFLLQIFP*CFQ*RFTWVAP*GDIRMLLCPSRI SIHFTPLPFISLCILNSLLFSLGAEGALERWFS MNQPRFL*KLGIPTTTTTAPYSSFKAPRLC*CPL RDEV*LLGPYDSSIAWPRRP*VAMSGLLFILRL FIA*NRSVSSQHKPNQSVYQCIWWQQLSPFKEQ GFRKGTLMVGSLLRASNVLPKPELRVGVPVVGAH YS*IRDMQGPEVA*LSPKYLCLCLSFLPLY*NP EQIPACLLMKRG*VKRVWRKKDTRRQAAG*ERV LRGGSNPEYLLF*PASLELLKGCAYHWLAHQGND FPAEGRKECFTLASFLEKLQPVLS*VVHTQTLA LWFSFLLVFALTLINRGEKNHPEVSMPLPF*W* HFVSLLHPSP*FHQGSHTRCNCFSAELYGLTSVH CKYTWDGVGLGLFREKQPDLLCELNVFLCNFEW PFNPKMNGFVLLVVVI*F*VFCV*KFGNNNIHF YMMPVNTTVFINE*IKLCFNF

Frame 1

LLVQSHKMGSSV*RRTVRGVATCLLKIGLLGKL LHKCVARCV*DSLTCFHLE*FDLAIEFLAIPGF MEIRGTGS*SGCSGELRQASAIVC*YSVFGC*LQ CAELRHQQVLGLECQKQQVLSDSCTG*GSRVFT ESTLQTSSADTKVYSRCHPNRPSRSRKDIQPVE GREASSGAAS*EAHRH*RA*GEP*EA*ALSSSSN RSWGGPAALGQESG*RAYLSSPEVPSSARQTHH ASISFYVKTLTLHQFPPAMDK*IFSP*F*EFRD YHKHYNCKGNGQK*E*RSRFG*AVL*EAVHPREE AAQGTTKRHRHQFLDKG*G*N*WL*RGQRNVA* KTF*VGIGR**SYNQ*FLR*PGFSKSPSGGPGG PPSHPDQPCRRRQQQRL*KTL*ECSD*KPKTENK TSGSPARASRYKVQA*EGGPAETRKDL*PIISA GDGETGEASLGAQNVRNGGRNEGVNRTEIRQPE AER*KWCPHQSHQQTVQVG*APDL*GKKGTAFAA PTPLFQSLPSNQKKWMFWWKDTSFYHPLQSPLY TLHFLCTFNALFFQTPIPSFMTVLIEA*LW*FE PSGECSGEYTRLSCGPLNFLLLSYFVHIGFGPNM *DFYPNQYPSAFYINPVSSDIGESCGSHSRILI GVPRETAGC*IDHQMPSGMVSIQGDSDCIEALY SSSPLRN*LLFFLSTPSNLPN*F*PLFLPHT*PF LQGANGPGFIYSFPFYPFIFFPSPPPHSMV*KL GQST*PQLSLAIVGSHYSGDKKIITLVPWWQHH CLLPGR*TMA*VSAHCFRLPLIFPLQSDFLYKKI WALNTPFCLTSLTLFSSLRPDTCF**EMKSVQG GMRGGEGRLLRDGLGSGSRLERHIWRKSSI*GH LQHCDKEDGR*QPTGL*E*W*I*LFPVVRFSREI YFLRN**GKWHLIEV*WNEVLSTH**ESWKFRV ARPRGH*VQLSIIVSQGPLLPQLSPMGMVR*PL VAMHLLLKSWATLITREFFLISAEVCLWILLVVQ IYYLQLFNGT*DMCSGWSPPQSYFELLLL*SFK SFLIWHAFLTCHILAILL*TKPAFKISCPGLER IQIQCKIKPLVLDDNLALILTVFSFCRSFIPWFT *VCKSLNPHHFRVASDIQCLEWFIPLIYTTSVC *FFPNMTCSSPWSSL*NTTCCLN*KL*FKIPIP PGAVAHACNPSTSGGRGGQITRSGVRDHPG*HGE TQSLLKIQKISQAWWQAPVVPATQEAEAGEWRE PGRRSLQ*ALITPLHSSLGDRARLHLKKNNNNK *IKNPNYRTGDMFPLTKPHF*SV*NSVFHFQPFF KRSCYYLETSYYHGSTVSSVLREC*IRVISFIS FILGEEINIRC*LIDYPGTF*ILGKEDDTSFSR KENWIIRNTS*PFSTQ*TRERGYREPPQICLCLS KVLGADSQNS*IGVASLPLHMTLPC*S*LFLPE SFPCDKKFASFSISGILDSIAKNS*K*V*TILG NFRYFLLCN*FY*LISGLSPEIKYHSFTTVLSGS PMRW*L*AFY*PAVLSGYWHQQVSFFLCCLDRY LLLASSVATILSPHLLVWRLMSTPGSSS*INSC RHGQQHGAQVCHLT*SLYMKYQNGKENVPGKTLF SLICYFSKTEPHLWK**FGHSRDSGAKVCFSRA ADPFPDSSRV**PQPHPNL*RKGYANLRVLPLK NLKNRHALGLLSVPDSLVGHSHLMFPRTSLSSNC RMCLLLFWASPGFCPSSHPKFKKT*IHLLLSEA TSEISDLSFATFYPFPFPKPCAY*MVPLRKQGS *NSS*WSVDPTKVCVNY*LFLH*RHLIEPKMMEE ETLKAMYFVRCLDFWPVCSLS*PQTDTVSSQRK ASVSVQATGECRHP*GGHGVSRRSLEKRELFKS VASYSASRRLCTSKGAKRKKKAERIQHLSRKKRE ILLYQMSHWFHWSLSVK*HCRSPGILPSEISSG ALKPHCLCQH*PHFKHTLTNQRSCNWPKSRPSY YYKS*SPYSLAQAGVQWCDLSSLQPPPPRLKGSS HLSSRAARTAGVHHHAQLIFEFFCRDGVLPCCP GWSEAAGLKQSTWLGLPKR*DYRRKGPRPAYHT DFQGRV*PFIRCEFFQPNKQAALRTKRQH*KIRP *KSEHLYSKATPSPFSHVTLGRSPSLSVK*GWT G*SLCALSFWLKIL*FIHS*EDQHIYWDFCFKN SF*PQKSKSRIFCFLLDLNCLI*AHQG*LLILFG K*I*Y*G*LNDVAMAFPPAGLVRILKPAEVEIG AHGEMDRKQFVAGSLWTSCFNRK*TCCFIGFLN HLSSAFLKWDLHWLFTPK*QTNRFSA*HRLVHCL ELCLTAARKFSSTRTSIFSSIELPLWILDLPEV GGSDTIQDGLSFKAGLKRRLPKQCLQTQSPHNH IA*NSTWLSQASYRTWCNWSERAETLEVEVAVCC DGKKAEGPGALDIEQGGSCKYWEGREFHRNKAL SHRNEFCLTGDFIPQAPAEQRF*SASLMGIDTA QEAVDPVRDSY*SFVF*LDWKIDQLHCSPGTVGH SY*E*GDF*GLRKNTESWPAASSCMVKDAFTSP LRVGVEGKHRTQVWLTTQCPGSPPSGEL*VRGG CV*RQYH**MFWPYLKRFSNLGITLGSSLCAFTC TFASPELLK*GLAYT*LQMKTQKPILFIKSYLL FFPLPSNPPKDLFELFPNSSAYFGP*ICQSDIF CYFSSKFFPDVSNKDLLGWPLKVTSGCSYVLPE* AYTSLLSLSSPSAFLIPCFSHLEPRVL*RGGFP *ISQDSCRSWVYQPPPPPPPIPVSKLLGYANVP SEMRFDF*ARMTPP*PGQGDHE*PCLVYSLS*DC L*LKTEVCLPSTNLINQCISASGGNSSAHSKSK DSGKAH*WWGAS*EPLMFSQNQS*ESECQSSGP TIPE*GTCKGQK*LDSRLNICAFACPFSHSTETR NRFPLAF**REVR*REFGGKKTPGGRLRGRRGF *EEAAIQNTSFSSQHPLNF*KVVPTTGWHTRAM ISLQKEGKNVSPLHPSWRSYSLCSVEWFTLRLWL YGFPSSLSLP*P*STGVKRTTLRFPCLSHFSGS ILCLYSTLHPSSTKVHTPDVTVFQLSCMD*LQS TVNTPGMGWGWGCLGRSSQTCFVN*MYFYAILSG LSTLR*MVLFYWLLLYSFEYSVFESLGIIIFTS I*CL*TQQYL*MSK*NCVLTL

Frame 2

CWYNLIKWAPVFREGQSEEWPPVC*KLGFWESC CTSVWQGVSEIA*PAFTWNDLIWQ*SSLPFLVL WKSEAQEVDLGVLGN*DKPLP*FVSTLCLDANS SVLS*DISKCWAWNVRSSRSYLTPVRDEEAESLR KARSRQARQTRRSTQGVTLTDLQEAERTFSRSR AERQAQEQPREKPTDTEGLEGSPEKHEPSAVPA TEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTT PASPSTSRPSLYTSSHLLWTNRFSVPDSESSET TTNTTTAKEMDKNENEEADLDEQSSKRLSIRER RRPKERRRGTGINFWTKDEDETDGSEEVKETWHE RLSRLESGGSNPTTSDSYGDRASARARREAREA RLATLTSRVEEDSNRDYKKLYESALTENQKLKT KLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVL EMEKRERRALERKMSEMEEEMKVLTELKSDNQR LKDENGALIRVISKLSK*ARLQIYEERKGQHLL PPPLFSSPCLPTKRNGCFGGRTLLSITLFSHLYT LYIFSALSMPCSSKPLSQVL*QF*LKHDCGNSS HLENALGSTPGSAVDPSTSCCSATLSTLDLVQT CKTSTLISILQLFTLTQCPLI*VSLVVATPGS*L GCQEKQQDVELIIRCPLEWLASKVTVTALRRSI LLHLSGTDFYFFCQHPVISLTSFNPYSSLIPSH FSKAQMALASFIPFLSILLYFSLPHPLTQWYKS* DRAPDLSCLWPLWEVIILETRKSSLWCLGGSTT ACSLEGRLWHKCQLIVFVSHLSSPFKVIFFIRK FGL*ILHSASLP*PCFPLFALTPASNEK*SQCKE E*EVGRGDC*EMD*EVEAGWKDTYGESQVSEAT CNIVTKKMEDSSLLGCENSGEFDYFQWLDLAER FTFLEINRGNGT**RFNGMKYFQPIDESHGSLEW QDPEVIRSSFLLLCHRDPCYHSFHPWAWSGSLW WLCIYYSKVGQL**RESFSSYQLKSACGFSL*S RSTICNSLTALEICAVGGLPLSLTLSCCYSSPLS HSSYGMLFLPVTSWPSSSRQNQPLKYHVQAWKE YKSSAKLNH*FLMIT*H*YLQYFLFVGVLSLGS LECASH*ILIILGLPVIFSV*SGSFP*YILPLSV NSFLT*HVALHGPPSETPHAV*TRSCNSRSQFH QVQWLMPVIPALQEAEVDRSRGQEFETILANTV KPNLY*KYKKLARRGGRRL*SQLLRRLRQENGVN PGGGACSEP*SRHCTPAWVTEQDSISKKIIIIN K*KIPITEQEICFL*QNPIFRVYKILSFISNHF SREAATILRLRIIMGVL*VQFSGNAKLE**VLYP SFWERKST*GVD*LIILEHFEYWGRKMILLSQE KKIGLLGIHLDPFPLNRPGKGVTESLLRSVCAF QKYWGQILKTLRLVLHPCHFT*PFHVKADFSCQK VFLVTRNLQAFQSQEYWIL*PRTHESKCKLS*V ISGTFSYAINFIN*FLVYLQR*NTIPSQLYCLE AP*DGNYRPSTSQQFSLDTGISRSPFSCAAWTGT YCWPLQWPQSSVLTCWFGDS*APQAAQAE*IAA DMANNMGLRSVT*LRVFT*NIRMGKRMFLVKLC FH*FVIFQKPSHTFGSNDLAIPEILGLKFVFPGL LILFQIAPEYDDPSPIPISSERVMQISGCCL*R I*RIDMLWAYSVYQIL*WAILI*CSLEPPCLPT AGCVYFSSGLPLVSVLVPTPSLRRLRFIYCYLRP LVRFQISLLQHFTHFPSPNHVLIRWFHSGSKEA KTQVNGLWIPRKCV*TTDCFSTRGI*LSQR*WK KKLSKPCTLLGVWIFGLFAASPSHRQTLSPLRER PVFRSRPLVSVGTLEVGME*AEEAWRRENYLKV LPVIQLPGGFAPPKVQKGKRKQKGFSI*AERKG KFYSTR*ATGSTGAYQ*SNTAGALVSFPQRYHQG PSNPIVYASTDRTLSTHLPIRGRVIGLNLGPVI TTNLSHHTLSPRLECSGVISAHCNLHLPGSRDP LTSAPEQLGLQVCTTMPS*FLNFFVEMGFCHVAQ AGLKLLGSSNPPGWASQSDRITGVRAHAQPTIL IFKAGSNPS*DVSSSNPISRQL*GQKGNIKR*D PRSQNICIPRPPLLLLVM*LWAGHPPCL*NEVGL DNLYVPFPFGLKFCDLFILRKISIFIGISASKI LSNLKNPSPEFFVFFWI*TV*YEHIKVDFSSFL GSEFNIEGN*MMLQWLSLLLAW*EY*SLQRWKLE LMEKWIESNLLQAAFGQVVLIGNRPAAS*VSST TFPQLS*NGIYIGSSHPNSRLIVFLLSTVWFIV LNSALQQQENFPRQEPQSLVPLSSPSGFWTYQK* EVLIPFKMVFPSKQV*RGDYQSSVYKPRVHTTI LHRTALGFHKPPTGPGVIGVKGQRPWKWRWLCA AMGRRQKAQGLWT*SRVEAASTGKEESFTETKLC HTEMSSVSLVTSSLRLQLSRDFNQLP*WVLTLL RKQ*TLSGTAIDLLCSD*IGK*INFIVVQELLV TATRNEVISEG*EKTQNLGQQPAAAW*KMHSLLL *ELGLRANIEPRFGLQPSVPEALLRENCK*EVG VSKDNTINECSGLT*KGLAIWG*LLDLAYVRSH AHLLAQSF*NEVWHILDYK*KLRNQFYLLNHIFC FSPSLLIPQRTYLSCSPIHLLILDHESARVIFS VISPPNFSLMFPIKIYLGGPLR*HQDALMSFQN KHTLHSSPFHLPLHS*FLAFLTWSRGCFREVVFH ESAKIPVEVGYTNHHHHRPLFQFQSSSAMLMSP QR*GLTFRPV*LLHSLAKETMSSHVWFTLYPET VYSLKQKCVFPAQT*SISVSVHLVATAQPIQRAR IQERHTDGGEPLKSL*CSPKTRVESRSASRRGP LFLNKGHARARSSLTLA*ISVPLPVLSPTLLKP GTDSRLPSDEERLGKESLEEKRHQEAGCGVGEGS ERRQQSRIPPFLASIP*TFERLCLPLAGTPGQ* FPCRRKERMFHPCILLGEATACAQLSGSHSDFG FMVFLPPCLCPDLDQQG*KEPP*GFHASPILVVA FCVFTPPFTLVPPRFTHQM*LFFS*VVWINFSP L*IHLGWGGVGVV*GEAARLAL*TECIFMQF*V AFQP*DEWFCFTGCCYIVLSILCLKVWE**YSLL YDACKHNSIYK*VNKTVF*L

Sequence NM_032105

GGCGGGAGGAGTAAAGATGGCGGCGCGAGGGTCTCCGCCCTCTGCTCCGGGCTGAAGCGCTCTGAGAGAGGCGGCAGCGGCAACTCGAGCCCCAACAGTA ATTTAGTGTTGGTAGTTTTGGCAGCAGCTGCCGAGGCCGGAGCAATGGCGGAACTGGAGCACCTAGGAGGGAAGCGGGCAGAGTCGGCGCGAATGCGGCG GGCAGAGCAGCTTCGGCGCTGGCGGGGCTCGCTGACAGAGCAGGAGCCTGCGGAGCGACGAGGCGCGGGGCGGCAGCCGCTGACCAGGCGCGGGAGCCCC AGGGTCCGCTTCGAGGACGGTGCTGTCTTTCTGGCCGCCTGCTCTAGCGGGGACACCGACGAGGTGAGAAAGCTTCTGGCAAGAGGTGCTGATATCAACA CGGTCAACGTGGACGGCTTGACAGCCCTGCACCAGGCATGTATTGATGAAAATTTGGACATGGTGAAGTTTCTGGTGGAGAACAGAGCCAATGTAAACCA GCAAGACAACGAGGGCTGGACACCCCTTCATGCAGCAGCTTCCTGTGGCTATCTCAACATAGCAGAGTATTTCATTAATCACGGAGCCAGTGTAGGTATT GTCAATAGTGAAGGTGAAGTTCCCTCTGACCTTGCAGAAGAGCCAGCCATGAAGGATCTTCTTCTGGAGCAAGTAAAGAAGCAAGGAGTTGATCTAGAGC AGTCAAGAAAAGAAGAAGAGCAGCAGATGTTGCAGGATGCCCGCCAGTGGCTCAACAGTGGGAAAATAGAGGATGTGAGGCAGGCTCGCTCAGGGGCTAC AGCCCTTCATGTGGCTGCTGCCAAGGGCTACTCTGAAGTCCTCAGACTTTTAATTCAGGCTGGCTATGAACTCAATGTTCAGGATTATGATGGCTGGACT CCCCTCCATGCTGCTGCACACTGGGGAGTGAAGGAGGCTTGCTCCATCCTGGCAGAAGCACTTTGTGACATGGATATTCGAAATAAACTGGGCCAGACAC CATTTGATGTGGCTGATGAGGGTCTCGTGGAGCATTTGGAGTTGCTCCAGAAGAAGCAGAATGTGCTTCGAAGTGAAAAGGAGACACGGAATAAACTCAT TGAGTCAGATCTGAACAGCAAGATTCAGAGTGGGTTCTTTAAGAACAAAGAGAAGATGCTCTATGAGGAGGAGACACCTAAGTCCCAAGAAATGGAGGAA GAAAATAAAGAATCTAGTAGCTCCAGCTCAGAGGAGGAGGAAGGTGAAGATGAAGCTTCTGAGTCAGAAACTGAGAAGGAGGCAGATAAAAAGCCAGAAG CCTTTGTCAATCATTCCAACTCTGAAAGCAAGAGTAGTATCACAGAGCAGATACCAGCACCAGCTCAAAATACCTTCTCTGCCTCTTCTGCTAGGAGGTT CTCTTCTGGCCTTTTTAACAAGCCAGAAGAGCCCAAAGATGAATCTCCTTCTTCATGGAGATTGGGACTGAGAAAAACTGGCAGCCACAACATGCTGAGT GAGGTGGCCAATTCCAGGGAACCTATAAGGGACCGAGGCTCTTCCATCTATCGCTCCTCTTCAAGCCCTCGGATTTCTGCTCTACTGGACAACAAAGATA AGGAGAGAGAAAACAAAAGCTATATTAGTTCACTAGCACCCCGGAAGCTCAACAGCACAAGTGATATTGAAGAAAAGGAGAACAGAGAATCAGCTGTTAA TCTAGTGAGGAGTGGCTCCTATACCCGGCAGCTATGGAGGGATGAAGCAAAAGGAAATGAAATCCCACAGACAATTGCTCCCTCCACCTATGTATCAACT TACTTGAAAAGGACTCCTCACAAATCCCAGGCCGACACAACAGCAGAGAAAACAGCAGACAATGTCTCTTCTAGCACCCCGCTCTGTGTGATCACCAATC GCCCTCTTCCTAGCACTGCCAATGGGGTTACAGCTACTCCTGTGCTCTCCATTACTGGAACAGATTCCTCTGTGGAAGCCAGGGAGAAGAGGAGGTCCTA TCTGACTCCTGTACGGGATGAGGAAGCAGAGTCTTTACGGAAAGCACGCTCCAGACAAGCTCGGCAGACACGAAGGTCTACTCAAGGTGTCACCCTAACA GACCTTCAAGAAGCAGAAAGGACATTCAGCCGGTCGAGGGCAGAGAGGCAAGCTCAGGAGCAGCCTCGTGAGAAGCCCACAGACACTGAAGGGCTTGAGG GGAGCCCTGAGAAGCATGAGCCCTCAGCAGTTCCAGCAACAGAAGCTGGGGAGGGCCAGCAGCCCTGGGGCAGGAGTCTGGATGAAGAGCCTATCTGTCA TCGCCTGAGGTGCCCAGCTCAGCCAGACAAACCCACCACGCCAGCATCTCCTTCTACGTCAAGACCCTCACTCTACACCAGTTCCCACCTGCTATGGACA AATAGATTTTCAGTCCCTGATTCTGAGAGTTCAGAGACTACCACAAACACTACAACTGCAAAGGAAATGGACAAAAATGAGAATGAAGAAGCAGATTTGG ATGAGCAGTCCTCTAAGAGGCTGTCCATCCGAGAGAGGAGGCGGCCCAAGGAACGACGAAGAGGCACAGGCATCAATTTCTGGACAAAGGATGAGGATGA AACTGATGGCTCTGAAGAGGTCAAAGAAACGTGGCATGAAAGACTTTCTAGGTTGGAATCGGGAGGTAGTAATCCTACAACCAGTGATTCTTACGGTGAC CGGGCTTCAGCAAGAGCCCGTCGGGAGGCCCGGGAGGCCCGCCTAGCCACCCTGACCAGCCGTGTAGAAGAAGACAGCAACAGAGATTATAAAAAACTCT ATGAGAGTGCTCTGACTGAAAACCAAAAACTGAAAACAAAACTTCAGGAAGCCCAGCTAGAGCTAGCAGATATAAAGTCCAAGCTTGAGAAGGTGGCCCA GCAGAAACAAGAAAAGACCTCTGACCGATCATCAGTGCTGGAGATGGAGAAACGGGAGAGGCGAGCCTTGGAGCGCAAAATGTCAGAAATGGAGGAAGAA ATGAAGAACCTCCACCAGCTAAAACAGATTCAAACCTTGAAGCAGATGAACGAGCAACTGCAGGCTGAGAACAGGGCCCTGACCCGAGTGGTGGCCAGAC TCTCGGAGTCCATCGAGTCCTCGGACACCCAGGAGCTCTAGTTCTTGCCCCTACTCTCCAACTCACTTCCCTCCTCCACTACTCCAGGTGTTAACAGAAC TGAAATCCGACAACCAGAGGCTGAAAGATGAAAATGGTGCCCTCATCAGAGTCATCAGCAAACTGTCCAAGTAGGCTAGGCTCCAGATTTATGAGGAAAG AAAGGGACAGCATTTGCTGCCCCCACCCCTCTTTTCCAGTCCTTGCCTTCCAACCAAAAGAAATGGATGTTTTGGTGGAAGGACACTTCTTTCTATCACC CTCTTCAGTCACCTCTATACACTCTACATTTTCTCTGCACTTTCAATGCCCTGTTCTTCCAAACCCCTATCCCAAGTTTTATGACAGTTTTAATTGAAGC ATGATTGTGGTAATTCGAGCCATCTGGAGAATGCTCTGGGGAGTACACCAGGCTCAGCTGTGGACCCCTCAACTTCCTGCTGCTCAGCTACTTTGTCCAC ATTGGATTTGGTCCAAACATGTAAGACTTCTACCCTAATCAGTATCCTTCAGCTTTTTACATTAACCCAGTGTCCTCTGATATAGGTGAGTCTTGTGGTA GCCACTCCAGGATCCTGATTGGGGTGCCAAGAGAAACAGCAGGATGTTGAATTGATCATCAGATGCCCTCTGGAATGGTTAGCATCCAAGGTGACAGTGA CTGCATTGAGGCGCTCTATTCTTCTTCACCTCTCAGGAACTGACTTTTATTTTTTCTGTCAACACCCAGTAATCTCCCTAACTAGTTTTAACCCTTATTC CTCCCTCATACCTAGCCATTTCTCCAAGGCGCAAATGGCCCTGGCTTCATTTATTCCTTTCCTTTCTATCCTTTTATATTTTTCCCTTCCCCACCCCCTC ACTCAATGGTATAAAAGCTAGGACAGAGCACCTGACCTCAGTTGTCTTTGGCCATTGTGGGAAGTCATTATTCTGGAGACAAGAAAATCATCACTCTGGT GCCTTGGTGGCAGCACCACTGCCTGCTCCCTGGAAGGTAGACTATGGCATAAGTGTCAGCTCATTGTTTTCGTCTCCCACTTATCTTCCCCCTTCAAAGT GATTTTCTTTATAAGAAAATTTGGGCTCTGAATACTCCATTCTGCCTCACTTCCTTGACCTTGTTTTCCTCTCTTCGCCCTGACACCTGCTTCTAATGAG AAATGAAGTCAGTGCAAGGAGGAATGAGAGGTGGGGAGGGGAGATTGTTGAGAGATGGACTAGGAAGTGGAAGCAGGCTGGAAAGACACATATGGCGAAA GTCAAGTATCTGAGGCCACTTGCAACATTGTGACAAAGAAGATGGAAGATAGCAGCCTACTGGGCTGTGAGAATAGTGGTGAATTTGATTATTTCCAGTG GTTAGATTTAGCAGAGAGATTTACTTTCTTAGAAATTAATAGGGGAAATGGCACTTAATAGAGGTTTAATGGAATGAAGTACTTTCAACCCATTGATGAG AGTCATGGAAGTTTAGAGTGGCAAGACCCAGAGGTCATTAGGTCCAGCTTTCTATTATTGTGTCACAGGGACCCCTGCTACCACAGCTTTCACCCATGGG CATGGTCAGGTAGCCTCTGGTGGCTATGCATTTATTACTCAAAAGTTGGGCAACTCTAATAACGAGAGAGTTTTTCCTCATATCAGCTGAAGTCTGCCTG TGGATTCTCCTTGTAGTCCAGATCTACTATCTGCAACTCTTTAACGGCACTTGAGATATGTGCAGTGGGTGGTCTCCCCCTCAGTCTTACTTTGAGCTGC TGTTACTCTAGTCCTTTAAGTCATTCCTCATATGGCATGCTTTTCTTACCTGTCACATCTTGGCCATCCTCCTCTAGACAAAACCAGCCTTTAAAATATC ATGTCCAGGCCTGGAAAGAATACAAATCCAGTGCAAAATTAAACCATTAGTTCTTGATGATAACCTAGCATTAATACTTACAGTATTTTCTTTTTGTAGG AGTTTTATCCCTTGGTTCACTTGAGTGTGCAAGTCATTAAATCCTCATCATTTTAGGGTTGCCAGTGATATTCAGTGTTTAGAGTGGTTCATTCCCTTAA TATATACTACCTCTGTCTGTTAATTCTTTCCTAACATGACATGTAGCTCTCCATGGTCCTCCCTCTGAAACACCACATGCTGTTTAAACTAGAAGCTGTA ATTCAAGATCCCAATTCCACCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTCAGGAGGCCGAGGTGGACAGATCACGAGGTCAGGAGTTCGAGAC CATCCTGGCTAACACGGTGAAACCCAATCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTG AGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCTTGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAA AAAAAATAATAATAATAAATAAATAAAAAATCCCAATTACAGAACAGGAGATATGTTTCCTCTGACAAAACCCCATTTTTAGAGTGTATAAAATTCTGTC TTTCATTTCCAACCATTTTTCAAGAGAAGCTGCTACTATCTTGAGACTTCGTATTATCATGGGAGTACTGTAAGTTCAGTTCTCAGGGAATGCTAAATTA GAGTAATAAGTTTTATATCCTTCATTCTGGGAGAGGAAATCAACATAAGGTGTTGACTAATTGATTATCCTGGAACATTTTGAATATTGGGGAAGGAAGA TGATACTTCTTTCTCAAGAAAAGAAAATTGGATTATTAGGAATACATCTTGACCCTTTTCCACTCAATAGACCAGGGAAAGGGGTTACAGAGAGCCTCCT CAGATCTGTTTGTGCCTTTCAAAAGTACTGGGGGCAGATTCTCAAAACTCTTAGATTGGTGTTGCATCCCTGCCACTTCACATGACCCTTCCATGTTAAA GCTGACTTTTCTTGCCAGAAAGTTTTCCTTGTGACAAGAAATTTGCAAGCTTTTCAATCTCAGGAATACTGGATTCTATAGCCAAGAACTCATGAAAGTA AGTGTAAACTATCCTAGGTAATTTCAGGTACTTTCTCTTATGCAATTAATTTTATTAACTGATTTCTGGTCTATCTCCAGAGATAAAATACCATTCCTTC ACAACTGTATTGTCTGGAAGCCCCATGAGATGGTAATTATAGGCCTTCTACTAGCCAGCAGTTCTCTCTGGATACTGGCATCAGCAGGTCTCCTTTTTCT TGTGCTGCTTGGACAGGTACCTACTGCTGGCCTCTTCAGTGGCCACAATCCTCAGTCCTCACCTGCTGGTTTGGAGACTCATGAGCACCCCAGGCAGCTC AAGCTGAATAAATAGCTGCAGACATGGCCAACAACATGGGGCTCAGGTCTGTCACTTAACTTAGAGTCTTTACATGAAATATCAGAATGGGAAAGAGAAT GTTCCTGGTAAAACTCTGTTTTCATTAATTTGTTATTTTTCAAAAACCGAGCCACACCTTTGGAAGTAATGATTTGGCCATTCCAGAGATTCTGGGGCTA AAGTTTGTTTTTCCAGGGCTGCTGATCCTTTTCCAGATAGCTCCAGAGTATGATGACCCCAGCCCCATCCCAATCTCTAGCGAAAGGGTTATGCAAATCT CAGGGTGTTGCCTCTAAAGAATCTAAAGAATAGACATGCTTTGGGCTTACTCAGTGTACCAGATTCTCTAGTGGGCCATTCTCATTTGATGTTCCCTAGA ACCTCCCTGTCTTCCAACTGCAGGATGTGTTTACTTCTCTTCTGGGCTTCCCCTGGTTTCTGTCCTAGTTCCCACCCCAAGTTTAAGAAGACTTAGATTC ATTTATTGCTATCTGAGGCCACTAGTGAGATTTCAGATCTCTCTTTTGCAACATTTTACCCATTTCCCTTCCCCAAACCATGTGCTTATTAGATGGTTCC ACTCAGGAAGCAAGGAAGCTAAAACTCAAGTTAATGGTCTGTGGATCCCACGAAAGTGTGTGTAAACTACTGACTGTTTCTCCACTAGAGGCATTTAATT GAGCCAAAGATGATGGAAGAAGAAACTCTCAAAGCCATGTACTTTGTTAGGTGTCTGGATTTTTGGCCTGTTTGCAGCCTCTCCTAGCCACAGACAGACA CTGTCTCCTCTCAGAGAAAGGCCAGTGTTTCGGTCCAGGCCACTGGTGAGTGTCGGCACCCTTGAGGTGGGCATGGAGTGAGCAGAAGAAGCCTGGAGAA GAGAGAACTATTTAAAAGTGTTGCCAGTTATTCAGCTTCCAGGCGGCTTTGCACCTCCAAAGGTGCAAAAAGGAAAAAGAAAGCAGAAAGGATTCAGCAT TTAAGCAGAAAGAAAAGGGAAATTCTACTCTACCAGATGAGCCACTGGTTCCACTGGAGCTTATCAGTGAAGTAACACTGCAGGAGCCCTGGTATCCTTC CCTCAGAGATATCATCAGGGGCCCTCAAACCCCATTGTTTATGCCAGCACTGACCGCACTTTAAGCACACACTTACCAATCAGAGGTCGTGTAATTGGCC TAAATCTAGGCCCAGTTATTACTACAAATCTTAGTCACCATACTCTCTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCT CCCAGGCTCAAGGGATCCTCTCACCTCAGCTCCCGAGCAGCTAGGACTGCAGGTGTGCACCACCATGCCCAGCTAATTTTTGAATTTTTTTGTAGAGATG GGGTTTTGCCATGTTGCCCAGGCTGGTCTGAAGCTGCTGGGCTCAAGCAATCCACCTGGCTGGGCCTCCCAAAGCGATAGGATTACAGGCGTAAGGGCCC ACGCCCAGCCTACCATACTGATTTTCAAGGCAGGGTCTAACCCTTCATAAGATGTGAGTTCTTCCAACCCAATAAGCAGGCAGCTTTGAGGACAAAAAGG CAACATTAAAAGATAAGACCCTAGAAGTCAGAACATCTGTATTCCAAGGCCACCCCTTCTCCTTTTAGTCATGTGACTTTGGGCAGGTCACCCTCCCTGT CTGTAAAATGAGGTTGGACTGGATAATCTTTATGTGCCCTTTCCTTTTGGCTTAAAATTCTGTGATTTATTCATTCTTAGGAAGATCAGCATATTTATTG GGATTTCTGCTTCAAAAATTCTTTCTAACCTCAAAAATCCAAGTCCAGAATTTTTTGTTTTCTTCTGGATTTAAACTGTTTAATATGAGCACATCAAGGT TGACTTCTCATCCTTTTTGGGAAGTGAATTTAATATTGAGGGTAATTGAATGATGTTGCAATGGCTTTCCCTCCTGCTGGCTTGGTAAGAATATTAAAGC CTGCAGAGGTGGAAATTGGAGCTCATGGAGAAATGGATAGAAAGCAATTTGTTGCAGGCAGCCTTTGGACAAGTTGTTTTAATAGGAAATAGACCTGCTG CTTCATAGGTTTCCTCAACCACCTTTCCTCAGCTTTCTTAAAATGGGATCTACATTGGCTCTTCACACCCAAATAGCAGACTAATCGTTTTTCTGCTTAG CACCGTCTGGTTCATTGTCTTGAACTCTGCCTTACAGCAGCAAGAAAATTTTCCTCGACAAGAACCTCAATCTTTAGTTCCATTGAGCTCCCCCTCTGGA TTTTGGACTTACCAGAAGTAGGAGGTTCTGATACCATTCAAGATGGTCTTTCCTTCAAAGCAGGTCTGAAGAGGAGACTACCAAAGCAGTGTTTACAAAC CCAGAGTCCACACAACCATATTGCATAGAACAGCACTTGGCTTTCACAAGCCTCCTACAGGACCTGGTGTAATTGGAGTGAAAGGGCAGAGACCCTGGAA GTGGAGGTGGCTGTGTGCTGCGATGGGAAGAAGGCAGAAGGCCCAGGGGCTTTGGACATAGAGCAGGGTGGAAGCTGCAAGTACTGGGAAGGAAGAGAGT TTCACAGAAACAAAGCTTTGTCACACAGAAATGAGTTCTGTCTCACTGGTGACTTCATCCCTCAGGCTCCAGCTGAGCAGAGATTTTAATCAGCTTCCTT AATGGGTATTGACACTGCTCAGGAAGCAGTAGACCCTGTCAGGGACAGCTATTGATCTTTTGTGTTCTGATTAGATTGGAAAATAGATCAACTTCATTGT AGTCCAGGAACTGTTGGTCACAGCTACTAGGAATGAGGTGATTTCTGAGGGCTGAGAAAAAACACAGAATCTTGGCCAGCAGCCAGCAGCTGCATGGTGA AAGATGCATTCACTTCTCCTTTGAGAGTTGGGGTTGAGGGCAAACATAGAACCCAGGTTTGGCTTACAACCCAGTGTCCCGGAAGCCCTCCTTCGGGAGA ACTGTAAGTAAGAGGTGGGTGTGTCTAAAGACAATACCATTAATGAATGTTCTGGCCTTACCTAAAAAGGTTTAGCAATTTGGGGATAACTCTTGGATCT AGCTTATGTGCGTTCACATGCACATTTGCTAGCCCAGAGCTTTTAAAATGAGGTCTGGCATATACTTGATTACAAATGAAAACTCAGAAACCAATTTTAT TTATTAAATCATATCTTTTGTTTTTCCCCCTCCCTTCTAATCCCCCAAAGGACCTATTTGAGCTGTTCCCCAATTCATCTGCTTATTTTGGACCATGAAT CTGCCAGAGTGATATTTTCTGTTATTTCTCCTCCAAATTTTTCCCTGATGTTTCCAATAAAGATTTACTTGGGTGGCCCCTTAAGGTGACATCAGGATGC TCTTATGTCCTTCCAGAATAAGCATACACTTCACTCCTCTCCCTTTCATCTCCCTCTGCATTCTTAATTCCTTGCTTTTCTCACTTGGAGCCGAGGGTGC TTTAGAGAGGTGGTTTTCCATGAATCAGCCAAGATTCCTGTAGAAGTTGGGTATACCAACCACCACCACCACCGCCCCCTATTCCAGTTTCAAAGCTCCT CGGCTATGCTAATGTCCCCTCAGAGATGAGGTTTGACTTTTAGGCCCGTATGACTCCTCCATAGCCTGGCCAAGGAGACCATGAGTAGCCATGTCTGGTT TACTCTTTATCCTGAGACTGTTTATAGCTTAAAACAGAAGTGTGTCTTCCCAGCACAAACCTAATCAATCAGTGTATCAGTGCATCTGGTGGCAACAGCT CAGCCCATTCAAAGAGCAAGGATTCAGGAAAGGCACACTGATGGTGGGGAGCCTCTTAAGAGCCTCTAATGTTCTCCCAAAACCAGAGTTGAGAGTCGGA GTGCCAGTCGTCGGGGCCCACTATTCCTGAATAAGGGACATGCAAGGGCCAGAAGTAGCTTGACTCTCGCCTAAATATCTGTGCCTTTGCCTGTCCTTTC TCCCACTCTACTGAAACCCGGAACAGATTCCCGCTTGCCTTCTGATGAAGAGAGGTTAGGTAAAGAGAGTTTGGAGGAAAAAAGACACCAGGAGGCAGGC TGCGGGGTAGGAGAGGGTTCTGAGAGGAGGCAGCAATCCAGAATACCTCCTTTTCTAGCCAGCATCCCTTGAACTTTTGAAAGGTTGTGCCTACCACTGG CTGGCACACCAGGGCAATGATTTCCCTGCAGAAGGAAGGAAAGAATGTTTCACCCTTGCATCCTTCTTGGAGAAGCTACAGCCTGTGCTCAGTTGAGTGG TTCACACTCAGACTTTGGCTTTATGGTTTTCCTTCCTCCTTGTCTTTGCCCTGACCTTGATCAACAGGGGTGAAAAGAACCACCCTGAGGTTTCCATGCC TCTCCCATTTTAGTGGTAGCATTTTGTGTCTTTACTCCACCCTTCACCCTAGTTCCACCAAGGTTCACACACCAGATGTAACTGTTTTTCAGCTGAGTTG TATGGATTAACTTCAGTCCACTGTAAATACACCTGGGATGGGGTGGGGTTGGGGTTGTTTAGGGAGAAGCAGCCAGACTTGCTTTGTGAACTGAATGTAT TTTTATGCAATTTTGAGTGGCCTTTCAACCCTAAGATGAATGGTTTTGTTTTACTGGTTGTTGTTATATAGTTTTGAGTATTCTGTGTTTGAAAGTTTGG GAATAATAATATTCACTTCTATATGATGCCTGTAAACACAACAGTATTTATAAATGAGTAAATAAAACTGTGTTTTAACTTTG

refseq_PPP1R12B.F1 (forward primer)
refseq_PPP1R12B.R1 (reverse primer)
Single exon skipping

Frame 0

GGRSKDGGARVSALCSGLKRSERGGSGNSSPNS NLVLVVLAAAAEAGAMAELEHLGGKRAESARMRR AEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP RVRFEDGAVFLAACSSGDTDEVRKLLARGADIN TVNVDGLTALHQACIDENLDMVKFLVENRANVNQ QDNEGWTPLHAAASCGYLNIAEYFINHGASVGI VNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLE QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGAT ALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWT PLHAAAHWGVKEACSILAEALCDMDIRNKLGQT PFDVADEGLVEHLELLQKKQNVLRSEKETRNKLI ESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEE ENKESSSSSSEEEEGEDEASESETEKEADKKPE AFVNHSNSESKSSITEQIPAPAQNTFSASSARRF SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLS EVANSREPIRDRGSSIYRSSSSPRISALLDNKD KERENKSYISSLAPRKLNSTSDIEEKENRESAVN LVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVST YLKRTPHKSQADTTAEKTADNVSSSTPLCVITN RPLPSTANGVTATPVLSITGTDSSVEAREKRRSY LTPVRDEEAESLRKARSRQARQTRRSTQGVTLT DLQEAERTFSRSRAERQAQEQPREKPTDTEGLE GSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICH RLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWT NRFSVPDSESSETTTNTTTAKEMDKNENEEADL DEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE TDGSEEVKETWHERLSRLESGGSNPTTSDSYGD RASARARREAREARLATLTSRVEEDSNRDYKKL YESALTENQKLKTKLQEAQLELADIKSKLEKVAQ QKQEKTSDRSSVLEMEKRERRALERKMSEMEEE MKNLHQLKQIQTLKQMNEQLQAENRALTRVVAR LSESIESSDTQEL*FLPLLSNSLPSSTTPGVNRT EIRQPEAER*KWCPHQSHQQTVQVG*APDL*GK KGTAFAAPTPLFQSLPSNQKKWMFWWKDTSFYH PLQSPLYTLHFLCTFNALFFQTPIPSFMTVLIEA *LW*FEPSGECSGEYTRLSCGPLNFLLLSYFVH IGFGPNM*DFYPNQYPSAFYINPVSSDIGESCG SHSRILIGVPRETAGC*IDHQMPSGMVSIQGDSD CIEALYSSSPLRN*LLFFLSTPSNLPN*F*PLF LPHT*PFLQGANGPGFIYSFPFYPFIFFPSPPP HSMV*KLGQST*PQLSLAIVGSHYSGDKKIITLV PWWQHHCLLPGR*TMA*VSAHCFRLPLIFPLQS DFLYKKIWALNTPFCLTSLTLFSSLRPDTCF** EMKSVQGGMRGGEGRLLRDGLGSGSRLERHIWRK SSI*GHLQHCDKEDGR*QPTGL*E*W*I*LFPV VRFSREIYFLRN**GKWHLIEV*WNEVLSTH** ESWKFRVARPRGH*VQLSIIVSQGPLLPQLSPMG MVR*PLVAMHLLLKSWATLITREFFLISAEVCL WILLVVQIYYLQLFNGT*DMCSGWSPPQSYFEL LLL*SFKSFLIWHAFLTCHILAILL*TKPAFKIS CPGLERIQIQCKIKPLVLDDNLALILTVFSFCR SFIPWFT*VCKSLNPHHFRVASDIQCLEWFIPL IYTTSVC*FFPNMTCSSPWSSL*NTTCCLN*KL* FKIPIPPGAVAHACNPSTSGGRGGQITRSGVRD HPG*HGETQSLLKIQKISQAWWQAPVVPATQEA EAGEWREPGRRSLQ*ALITPLHSSLGDRARLHLK KNNNNK*IKNPNYRTGDMFPLTKPHF*SV*NSV FHFQPFFKRSCYYLETSYYHGSTVSSVLREC*I RVISFISFILGEEINIRC*LIDYPGTF*ILGKED DTSFSRKENWIIRNTS*PFSTQ*TRERGYREPP QICLCLSKVLGADSQNS*IGVASLPLHMTLPC* S*LFLPESFPCDKKFASFSISGILDSIAKNS*K* V*TILGNFRYFLLCN*FY*LISGLSPEIKYHSF TTVLSGSPMRW*L*AFY*PAVLSGYWHQQVSFF LCCLDRYLLLASSVATILSPHLLVWRLMSTPGSS S*INSCRHGQQHGAQVCHLT*SLYMKYQNGKEN VPGKTLFSLICYFSKTEPHLWK**FGHSRDSGA KVCFSRAADPFPDSSRV**PQPHPNL*RKGYANL RVLPLKNLKNRHALGLLSVPDSLVGHSHLMFPR TSLSSNCRMCLLLFWASPGFCPSSHPKFKKT*I HLLLSEATSEISDLSFATFYPFPFPKPCAY*MVP LRKQGS*NSS*WSVDPTKVCVNY*LFLH*RHLI EPKMMEEETLKAMYFVRCLDFWPVCSLS*PQTD TVSSQRKASVSVQATGECRHP*GGHGVSRRSLEK RELFKSVASYSASRRLCTSKGAKRKKKAERIQH LSRKKREILLYQMSHWFHWSLSVK*HCRSPGIL PSEISSGALKPHCLCQH*PHFKHTLTNQRSCNWP KSRPSYYYKS*SPYSLAQAGVQWCDLSSLQPPP PRLKGSSHLSSRAARTAGVHHHAQLIFEFFCRD GVLPCCPGWSEAAGLKQSTWLGLPKR*DYRRKGP RPAYHTDFQGRV*PFIRCEFFQPNKQAALRTKR QH*KIRP*KSEHLYSKATPSPFSHVTLGRSPSL SVK*GWTG*SLCALSFWLKIL*FIHS*EDQHIYW DFCFKNSF*PQKSKSRIFCFLLDLNCLI*AHQG *LLILFGK*I*Y*G*LNDVAMAFPPAGLVRILK PAEVEIGAHGEMDRKQFVAGSLWTSCFNRK*TCC FIGFLNHLSSAFLKWDLHWLFTPK*QTNRFSA* HRLVHCLELCLTAARKFSSTRTSIFSSIELPLW ILDLPEVGGSDTIQDGLSFKAGLKRRLPKQCLQT QSPHNHIA*NSTWLSQASYRTWCNWSERAETLE VEVAVCCDGKKAEGPGALDIEQGGSCKYWEGRE FHRNKALSHRNEFCLTGDFIPQAPAEQRF*SASL MGIDTAQEAVDPVRDSY*SFVF*LDWKIDQLHC SPGTVGHSY*E*GDF*GLRKNTESWPAASSCMV KDAFTSPLRVGVEGKHRTQVWLTTQCPGSPPSGE L*VRGGCV*RQYH**MFWPYLKRFSNLGITLGS SLCAFTCTFASPELLK*GLAYT*LQMKTQKPIL FIKSYLLFFPLPSNPPKDLFELFPNSSAYFGP*I CQSDIFCYFSSKFFPDVSNKDLLGWPLKVTSGC SYVLPE*AYTSLLSLSSPSAFLIPCFSHLEPRV L*RGGFP*ISQDSCRSWVYQPPPPPPPIPVSKLL GYANVPSEMRFDF*ARMTPP*PGQGDHE*PCLV YSLS*DCL*LKTEVCLPSTNLINQCISASGGNS SAHSKSKDSGKAH*WWGAS*EPLMFSQNQS*ESE CQSSGPTIPE*GTCKGQK*LDSRLNICAFACPF SHSTETRNRFPLAF**REVR*REFGGKKTPGGR LRGRRGF*EEAAIQNTSFSSQHPLNF*KVVPTTG WHTRAMISLQKEGKNVSPLHPSWRSYSLCSVEW FTLRLWLYGFPSSLSLP*P*STGVKRTTLRFPC LSHFSGSILCLYSTLHPSSTKVHTPDVTVFQLSC MD*LQSTVNTPGMGWGWGCLGRSSQTCFVN*MY FYAILSGLSTLR*MVLFYWLLLYSFEYSVFESL GIIIFTSI*CL*TQQYL*MSK*NCVLTL

Frame 1

AGGVKMAARGSPPSAPG*SALREAAAATRAPTV I*CW*FWQQLPRPEQWRNWST*EGSGQSRRECG GQSSFGAGGAR*QSRSLRSDEARGGSR*PGAGAP GSASRTVLSFWPPALAGTPTR*ESFWQEVLIST RSTWTA*QPCTRHVLMKIWTW*SFWWRTEPM*T SKTTRAGHPFMQQLPVAIST*QSISLITEPV*VL SIVKVKFPLTLQKSQP*RIFFWSK*RSKELI*S SQEKKKSSRCCRMPASGSTVGK*RM*GRLAQGL QPFMWLLPRATLKSSDF*FRLAMNSMFRIMMAGL PSMLLHTGE*RRLAPSWQKHFVTWIFEINWARH HLMWLMRVSWSIWSCSRRSRMCFEVKRRHGINS LSQI*TARFRVGSLRTKRRCSMRRRHLSPKKWRK KIKNLVAPAQRRRKVKMKLLSQKLRRRQIKSQK PLSIIPTLKARVVSQSRYQHQLKIPSLPLLLGG SLLAFLTSQKSPKMNLLLHGDWD*EKLAATTC*V RWPIPGNL*GTEALPSIAPLQALGFLLYWTTKI RREKTKAILVH*HPGSSTAQVILKKRRTENQLL I**GVAPIPGSYGGMKQKEMKSHRQLLPPPMYQL T*KGLLTNPRPTQQQRKQQTMSLLAPRSV*SPI ALFLALPMGLQLLLCSPLLEQIPLWKPGRRGGP I*LLYGMRKQSLYGKHAPDKLGRHEGLLKVSP*Q TFKKQKGHSAGRGQRGKLRSSLVRSPQTLKGLR GALRSMSPQQFQQQKLGRASSPGAGVWMKSLSV IA*GAQLSQTNPPRQHLLLRQDPHSTPVPTCYGQ IDFQSLILRVQRLPQTLQLQRKWTKMRMKKQIW MSSPLRGCPSERGGGPRNDEEAQASISGQRMRM KLMALKRSKKRGMKDFLGWNREVVILQPVILTVT GLQQEPVGRPGRPA*PP*PAV*KKTATEIIKNS MRVL*LKTKN*KQNFRKPS*S*QI*SPSLRRWP SRNKKRPLTDHQCWRWRNGRGEPWSAKCQKWRKK *RTSTS*NRFKP*SR*TSNCRLRTGP*PEWWPD SRSPSSPRTPRSSSSCPYSPTHFPPPLLQVLTE LKSDNQRLKDENGALIRVISKLSK*ARLQIYEER KGQHLLPPPLFSSPCLPTKRNGCFGGRTLLSIT LFSHLYTLYIFSALSMPCSSKPLSQVL*QF*LK HDCGNSSHLENALGSTPGSAVDPSTSCCSATLST LDLVQTCKTSTLISILQLFTLTQCPLI*VSLVV ATPGS*LGCQEKQQDVELIIRCPLEWLASKVTV TALRRSILLHLSGTDFYFFCQHPVISLTSFNPYS SLIPSHFSKAQMALASFIPFLSILLYFSLPHPL TQWYKS*DRAPDLSCLWPLWEVIILETRKSSLW CLGGSTTACSLEGRLWHKCQLIVFVSHLSSPFKV IFFIRKFGL*ILHSASLP*PCFPLFALTPASNE K*SQCKEE*EVGRGDC*EMD*EVEAGWKDTYGE SQVSEATCNIVTKKMEDSSLLGCENSGEFDYFQW LDLAERFTFLEINRGNGT**RFNGMKYFQPIDE SHGSLEWQDPEVIRSSFLLLCHRDPCYHSFHPW AWSGSLWWLCIYYSKVGQL**RESFSSYQLKSAC GFSL*SRSTICNSLTALEICAVGGLPLSLTLSC CYSSPLSHSSYGMLFLPVTSWPSSSRQNQPLKY HVQAWKEYKSSAKLNH*FLMIT*H*YLQYFLFVG VLSLGSLECASH*ILIILGLPVIFSV*SGSFP* YILPLSVNSFLT*HVALHGPPSETPHAV*TRSC NSRSQFHQVQWLMPVIPALQEAEVDRSRGQEFET ILANTVKPNLY*KYKKLARRGGRRL*SQLLRRL RQENGVNPGGGACSEP*SRHCTPAWVTEQDSIS KKIIIINK*KIPITEQEICFL*QNPIFRVYKILS FISNHFSREAATILRLRIIMGVL*VQFSGNAKL E**VLYPSFWERKST*GVD*LIILEHFEYWGRK MILLSQEKKIGLLGIHLDPFPLNRPGKGVTESLL RSVCAFQKYWGQILKTLRLVLHPCHFT*PFHVK ADFSCQKVFLVTRNLQAFQSQEYWIL*PRTHES KCKLS*VISGTFSYAINFIN*FLVYLQR*NTIPS QLYCLEAP*DGNYRPSTSQQFSLDTGISRSPFS CAAWTGTYCWPLQWPQSSVLTCWFGDS*APQAA QAE*IAADMANNMGLRSVT*LRVFT*NIRMGKRM FLVKLCFH*FVIFQKPSHTFGSNDLAIPEILGL KFVFPGLLILFQIAPEYDDPSPIPISSERVMQI SGCCL*RI*RIDMLWAYSVYQIL*WAILI*CSLE PPCLPTAGCVYFSSGLPLVSVLVPTPSLRRLRF IYCYLRPLVRFQISLLQHFTHFPSPNHVLIRWF HSGSKEAKTQVNGLWIPRKCV*TTDCFSTRGI*L SQR*WKKKLSKPCTLLGVWIFGLFAASPSHRQT LSPLRERPVFRSRPLVSVGTLEVGME*AEEAWR RENYLKVLPVIQLPGGFAPPKVQKGKRKQKGFSI *AERKGKFYSTR*ATGSTGAYQ*SNTAGALVSF PQRYHQGPSNPIVYASTDRTLSTHLPIRGRVIG LNLGPVITTNLSHHTLSPRLECSGVISAHCNLHL PGSRDPLTSAPEQLGLQVCTTMPS*FLNFFVEM GFCHVAQAGLKLLGSSNPPGWASQSDRITGVRA HAQPTILIFKAGSNPS*DVSSSNPISRQL*GQKG NIKR*DPRSQNICIPRPPLLLLVM*LWAGHPPC L*NEVGLDNLYVPFPFGLKFCDLFILRKISIFI GISASKILSNLKNPSPEFFVFFWI*TV*YEHIKV DFSSFLGSEFNIEGN*MMLQWLSLLLAW*EY*S LQRWKLELMEKWIESNLLQAAFGQVVLIGNRPA AS*VSSTTFPQLS*NGIYIGSSHPNSRLIVFLLS TVWFIVLNSALQQQENFPRQEPQSLVPLSSPSG FWTYQK*EVLIPFKMVFPSKQV*RGDYQSSVYK PRVHTTILHRTALGFHKPPTGPGVIGVKGQRPWK WRWLCAAMGRRQKAQGLWT*SRVEAASTGKEES FTETKLCHTEMSSVSLVTSSLRLQLSRDFNQLP *WVLTLLRKQ*TLSGTAIDLLCSD*IGK*INFIV VQELLVTATRNEVISEG*EKTQNLGQQPAAAW* KMHSLLL*ELGLRANIEPRFGLQPSVPEALLRE NCK*EVGVSKDNTINECSGLT*KGLAIWG*LLDL AYVRSHAHLLAQSF*NEVWHILDYK*KLRNQFY LLNHIFCFSPSLLIPQRTYLSCSPIHLLILDHE SARVIFSVISPPNFSLMFPIKIYLGGPLR*HQDA LMSFQNKHTLHSSPFHLPLHS*FLAFLTWSRGC FREVVFHESAKIPVEVGYTNHHHHRPLFQFQSS SAMLMSPQR*GLTFRPV*LLHSLAKETMSSHVWF TLYPETVYSLKQKCVFPAQT*SISVSVHLVATA QPIQRARIQERHTDGGEPLKSL*CSPKTRVESR SASRRGPLFLNKGHARARSSLTLA*ISVPLPVLS PTLLKPGTDSRLPSDEERLGKESLEEKRHQEAG CGVGEGSERRQQSRIPPFLASIP*TFERLCLPL AGTPGQ*FPCRRKERMFHPCILLGEATACAQLSG SHSDFGFMVFLPPCLCPDLDQQG*KEPP*GFHA SPILVVAFCVFTPPFTLVPPRFTHQM*LFFS*V VWINFSPL*IHLGWGGVGVV*GEAARLAL*TECI FMQF*VAFQP*DEWFCFTGCCYIVLSILCLKVW E**YSLLYDACKHNSIYK*VNKTVF*L

Frame 2

REE*RWRREGLRPLLRAEAL*ERRQRQLEPQQ* FSVGSFGSSCRGRSNGGTGAPRREAGRVGANAA GRAASALAGLADRAGACGATRRGAAAADQAREP QGPLRGRCCLSGRLL*RGHRRGEKASGKRC*YQH GQRGRLDSPAPGMY**KFGHGEVSGGEQSQCKP ARQRGLDTPSCSSFLWLSQHSRVFH*SRSQCRY CQ**R*SSL*PCRRASHEGSSSGASKEARS*SRA VKKRRRAADVAGCPPVAQQWENRGCEAGSLRGY SPSCGCCQGLL*SPQTFNSGWL*TQCSGL*WLD SPPCCCTLGSEGGLLHPGRSTL*HGYSK*TGPDT I*CG**GSRGAFGVAPEEAECASK*KGDTE*TH *VRSEQQDSEWVL*EQREDAL*GGDT*VPRNGG RK*RI**LQLRGGGR*R*SF*VRN*EGGR*KARS LCQSFQL*KQE*YHRADTSTSSKYLLCLFC*EV LFWPF*QARRAQR*ISFFMEIGTEKNWQPQHAE *GGQFQGTYKGPRLFHLSLLFKPSDFCSTGQQR* GERKQKLY*FTSTPEAQQHK*Y*RKGEQRISC* SSEEWLLYPAAMEG*SKRK*NPTDNCSLHLCIN LLEKDSSQIPGRHNSRENSRQCLF*HPALCDHQS PSS*HCQWGYSYSCALHYWNRFLCGSQGEEEVL SDSCTG*GSRVFTESTLQTSSADTKVYSRCHPN RPSRSRKDIQPVEGREASSGAAS*EAHRH*RA*G EP*EA*ALSSSSNRSWGGPAALGQESG*RAYLS SPEVPSSARQTHHASISFYVKTLTLHQFPPAMD K*IFSP*F*EFRDYHKHYNCKGNGQK*E*RSRFG *AVL*EAVHPREEAAQGTTKRHRHQFLDKG*G* N*WL*RGQRNVA*KTF*VGIGR**SYNQ*FLR* PGFSKSPSGGPGGPPSHPDQPCRRRQQQRL*KTL *ECSD*KPKTENKTSGSPARASRYKVQA*EGGP AETRKDL*PIISAGDGETGEASLGAQNVRNGGR NEEPPPAKTDSNLEADERATAG*EQGPDPSGGQT LGVHRVLGHPGALVLAPTLQLTSLLHYSRC*QN *NPTTRG*KMKMVPSSESSANCPSRLGSRFMRK ERDSICCPHPSFPVLAFQPKEMDVLVEGHFFLSP SSVTSIHSTFSLHFQCPVLPNPYPKFYDSFN*S MIVVIRAIWRMLWGVHQAQLWTPQLPAAQLLCP HWIWSKHVRLLP*SVSFSFLH*PSVL*YR*VLW* PLQDPDWGAKRNSRMLN*SSDALWNG*HPR*Q* LH*GALFFFTSQELTFIFSVNTQ*SP*LVLTLI PPSYLAISPRRKWPWLHLFLSFLSFYIFPFPTPS LNGIKARTEHLTSVVFGHCGKSLFWRQENHHSG ALVAAPLPAPWKVDYGISVSSLFSSPTYLPPSK *FSL*ENLGSEYSILPHFLDLVFLSSP*HLLLMR NEVSARRNERWGGEIVERWTRKWKQAGKTHMAK VKYLRPLATL*QRRWKIAAYWAVRIVVNLIISS G*I*QRDLLS*KLIGEMALNRGLME*STFNPLMR VMEV*SGKTQRSLGPAFYYCVTGTPATTAFTHG HGQVASGGYAFITQKLGNSNNERVFPHIS*SLP VDSPCSPDLLSATL*RHLRYVQWVVSPSVLL*AA VTLVL*VIPHMACFSYLSHLGHPPLDKTSL*NI MSRPGKNTNPVQN*TISS***PSINTYSIFFL* EFYPLVHLSVQVIKSSSF*GCQ*YSVFRVVHSLN IYYLCLLILS*HDM*LSMVLPLKHHMLFKLEAV IQDPNSTRCSGSCL*SQHFRRPRWTDHEVRSSR PSWLTR*NPISTKNTKN*PGVVAGACSPSYSGG* GRRMA*TREAELAVSLDHATALQPG*QSKTPSQ KK****INKKSQLQNRRYVSSDKTPFLECIKFC LSFPTIFQEKLLLS*DFVLSWEYCKFSSQGMLN* SNKFYILHSGRGNQHKVLTN*LSWNILNIGEGR *YFFLKKRKLDY*EYILTLFHSIDQGKGLQRAS SDLFVPFKSTGGRFSKLLDWCCIPATSHDPSMLK LTFLARKFSL*QEICKLFNLRNTGFYSQELMKV SVNYPR*FQVLSLMQLILLTDFWSISRDKIPFL HNCIVWKPHEMVIIGLLLASSSLWILASAGLLFL VLLGQVPTAGLFSGHNPQSSPAGLETHEHPRQL KLNK*LQTWPTTWGSGLSLNLESLHEISEWERE CSW*NSVFINLLFFKNRATPLEVMIWPFQRFWG* SLFFQGC*SFSR*LQSMMTPAPSQSLAKGLCKS QGVASKESKE*TCFGLTQCTRFSSGPFSFDVP* NLPVFQLQDVFTSLLGFPWFLS*FPPQV*EDLDS FIAI*GH**DFRSLFCNILPISLPQTMCLLDGS TQEARKLKLKLMVCGSHESVCKLLTVSPLEAFN *AKDDGRRNSQSHVLC*VSGFLACLQPLLATDRH CLLSEKGQCFGPGHW*VSAPLRWAWSEQKKPGE ERTI*KCCQLFSFQAALHLQRCKKEKESRKDSA FKQKEKGNSTLPDEPLVPLELISEVTLQEPWYPS LRDIIRGPQTPLFMPALTAL*AHTYQSEVV*LA *I*AQLLLQILVTILSRPGWSAVV*SQLTATST SQAQGILSPQLPSS*DCRCAPPCPANF*IFL*RW GFAMLPRLV*SCWAQAIHLAGPPKAIGLQA*GP TPSLPY*FSRQGLTLHKM*VLPTQ*AGSFEDKK ATLKDKTLEVRTSVFQGHPFSF*SCDFGQVTLPV CKMRLDWIIFMCPFLLA*NSVIYSFLGRSAYLL GFLLQKFFLTSKIQVQNFLFSSGFKLFNMSTSR LTSHPFWEVNLILRVIE*CCNGFPSCWLGKNIKA CRGGNWSSWRNG*KAICCRQPLDKLF**EIDLL LHRFPQPPFLSFLKMGSTLALHTQIAD*SFFCL APSGSLS*TLPYSSKKIFLDKNLNL*FH*APPLD FGLTRSRRF*YHSRWSFLQSRSEEETTKAVFTN PESTQPYCIEQHLAFTSLLQDLV*LE*KGRDPG SGGGCVLRWEEGRRPRGFGHRAGWKLQVLGRKRV SQKQSFVTQK*VLSHW*LHPSGSS*AEILISFL NGY*HCSGSSRPCQGQLLIFCVLIRLENRSTSL *SRNCWSQLLGMR*FLRAEKKHRILASSQQLHGE RCIHFSFESWG*GQT*NPGLAYNPVSRKPSFGR TVSKRWVCLKTIPLMNVLALPKKV*QFGDNSWI *LMCVHMHIC*PRAFKMRSGIYLITNENSETNFI Y*IISFVFPPPF*SPKGPI*AVPQFICLFWTMN LPE*YFLLFLLQIFP*CFQ*RFTWVAP*GDIRM LLCPSRISIHFTPLPFISLCILNSLLFSLGAEGA LERWFSMNQPRFL*KLGIPTTTTTAPYSSFKAP RLC*CPLRDEV*LLGPYDSSIAWPRRP*VAMSG LLFILRLFIA*NRSVSSQHKPNQSVYQCIWWQQL SPFKEQGFRKGTLMVGSLLRASNVLPKPELRVG VPVVGAHYS*IRDMQGPEVA*LSPKYLCLCLSF LPLY*NPEQIPACLLMKRG*VKRVWRKKDTRRQA AG*ERVLRGGSNPEYLLF*PASLELLKGCAYHW LAHQGNDFPAEGRKECFTLASFLEKLQPVLS*V VHTQTLALWFSFLLVFALTLINRGEKNHPEVSMP LPF*W*HFVSLLHPSP*FHQGSHTRCNCFSAEL YGLTSVHCKYTWDGVGLGLFREKQPDLLCELNV FLCNFEWPFNPKMNGFVLLVVVI*F*VFCV*KFG NNNIHFYMMPVNTTVFINE*IKLCFNF

Sequence NM_032104

GTTGCTGGTACAATCTCATAAAATGGGCTCCAGTGTTTAGAGAAGGACAGTCAGAGGAGTGGCCACCTGTTTGTTGAAAATTGGGCTTCTGGGAAAGTTG CTGCACAAGTGTGTGGCAAGGTGTGTCTGAGATAGCTTGACCTGCTTTCACCTGGAATGATTTGATCTGGCAATAGAGTTCCTTGCCATTCCTGGTTTTA TGGAAATCAGAGGCACAGGAAGTTGATCTGGGTGTTCTGGGGAATTGAGACAAGCCTCTGCCATAGTTTGTTAGTACTCTGTGTTTGGATGCTAACTCCA GTGTGCTGAGTTGAGACATCAGCAAGTGCTGGGCCTGGAATGTCAGAAGCAGCAGGTCCTATCTGACTCCTGTACGGGATGAGGAAGCAGAGTCTTTACG GAAAGCACGCTCCAGACAAGCTCGGCAGACACGAAGGTCTACTCAAGGTGTCACCCTAACAGACCTTCAAGAAGCAGAAAGGACATTCAGCCGGTCGAGG GCAGAGAGGCAAGCTCAGGAGCAGCCTCGTGAGAAGCCCACAGACACTGAAGGGCTTGAGGGGAGCCCTGAGAAGCATGAGCCCTCAGCAGTTCCAGCAA CAGAAGCTGGGGAGGGCCAGCAGCCCTGGGGCAGGAGTCTGGATGAAGAGCCTATCTGTCATCGCCTGAGGTGCCCAGCTCAGCCAGACAAACCCACCAC GCCAGCATCTCCTTCTACGTCAAGACCCTCACTCTACACCAGTTCCCACCTGCTATGGACAAATAGATTTTCAGTCCCTGATTCTGAGAGTTCAGAGACT ACCACAAACACTACAACTGCAAAGGAAATGGACAAAAATGAGAATGAAGAAGCAGATTTGGATGAGCAGTCCTCTAAGAGGCTGTCCATCCGAGAGAGGA GGCGGCCCAAGGAACGACGAAGAGGCACAGGCATCAATTTCTGGACAAAGGATGAGGATGAAACTGATGGCTCTGAAGAGGTCAAAGAAACGTGGCATGA AAGACTTTCTAGGTTGGAATCGGGAGGTAGTAATCCTACAACCAGTGATTCTTACGGTGACCGGGCTTCAGCAAGAGCCCGTCGGGAGGCCCGGGAGGCC CGCCTAGCCACCCTGACCAGCCGTGTAGAAGAAGACAGCAACAGAGATTATAAAAAACTCTATGAGAGTGCTCTGACTGAAAACCAAAAACTGAAAACAA AACTTCAGGAAGCCCAGCTAGAGCTAGCAGATATAAAGTCCAAGCTTGAGAAGGTGGCCCAGCAGAAACAAGAAAAGACCTCTGACCGATCATCAGTGCT GGAGATGGAGAAACGGGAGAGGCGAGCCTTGGAGCGCAAAATGTCAGAAATGGAGGAAGAAATGAAGAACCTCCACCAGCTAAAACAGATTCAAACCTTG AAGCAGATGAACGAGCAACTGCAGGCTGAGAACAGGGCCCTGACCCGAGTGGTGGCCAGACTCTCGGAGTCCATCGAGTCCTCGGACACCCAGGAGCTCT AGTTCTTGCCCCTACTCTCCAACTCACTTCCCTCCTCCACTACTCCAGGTGTTAACAGAACTGAAATCCGACAACCAGAGGCTGAAAGATGAAAATGGTG CCCTCATCAGAGTCATCAGCAAACTGTCCAAGTAGGCTAGGCTCCAGATTTATGAGGAAAGAAAGGGACAGCATTTGCTGCCCCCACCCCTCTTTTCCAG TCCTTGCCTTCCAACCAAAAGAAATGGATGTTTTGGTGGAAGGACACTTCTTTCTATCACCCTCTTCAGTCACCTCTATACACTCTACATTTTCTCTGCA CTTTCAATGCCCTGTTCTTCCAAACCCCTATCCCAAGTTTTATGACAGTTTTAATTGAAGCATGATTGTGGTAATTCGAGCCATCTGGAGAATGCTCTGG GGAGTACACCAGGCTCAGCTGTGGACCCCTCAACTTCCTGCTGCTCAGCTACTTTGTCCACATTGGATTTGGTCCAAACATGTAAGACTTCTACCCTAAT CAGTATCCTTCAGCTTTTTACATTAACCCAGTGTCCTCTGATATAGGTGAGTCTTGTGGTAGCCACTCCAGGATCCTGATTGGGGTGCCAAGAGAAACAG CAGGATGTTGAATTGATCATCAGATGCCCTCTGGAATGGTTAGCATCCAAGGTGACAGTGACTGCATTGAGGCGCTCTATTCTTCTTCACCTCTCAGGAA CTGACTTTTATTTTTTCTGTCAACACCCAGTAATCTCCCTAACTAGTTTTAACCCTTATTCCTCCCTCATACCTAGCCATTTCTCCAAGGCGCAAATGGC CCTGGCTTCATTTATTCCTTTCCTTTCTATCCTTTTATATTTTTCCCTTCCCCACCCCCTCACTCAATGGTATAAAAGCTAGGACAGAGCACCTGACCTC AGTTGTCTTTGGCCATTGTGGGAAGTCATTATTCTGGAGACAAGAAAATCATCACTCTGGTGCCTTGGTGGCAGCACCACTGCCTGCTCCCTGGAAGGTA GACTATGGCATAAGTGTCAGCTCATTGTTTTCGTCTCCCACTTATCTTCCCCCTTCAAAGTGATTTTCTTTATAAGAAAATTTGGGCTCTGAATACTCCA TTCTGCCTCACTTCCTTGACCTTGTTTTCCTCTCTTCGCCCTGACACCTGCTTCTAATGAGAAATGAAGTCAGTGCAAGGAGGAATGAGAGGTGGGGAGG GGAGATTGTTGAGAGATGGACTAGGAAGTGGAAGCAGGCTGGAAAGACACATATGGCGAAAGTCAAGTATCTGAGGCCACTTGCAACATTGTGACAAAGA AGATGGAAGATAGCAGCCTACTGGGCTGTGAGAATAGTGGTGAATTTGATTATTTCCAGTGGTTAGATTTAGCAGAGAGATTTACTTTCTTAGAAATTAA TAGGGGAAATGGCACTTAATAGAGGTTTAATGGAATGAAGTACTTTCAACCCATTGATGAGAGTCATGGAAGTTTAGAGTGGCAAGACCCAGAGGTCATT AGGTCCAGCTTTCTATTATTGTGTCACAGGGACCCCTGCTACCACAGCTTTCACCCATGGGCATGGTCAGGTAGCCTCTGGTGGCTATGCATTTATTACT CAAAAGTTGGGCAACTCTAATAACGAGAGAGTTTTTCCTCATATCAGCTGAAGTCTGCCTGTGGATTCTCCTTGTAGTCCAGATCTACTATCTGCAACTC TTTAACGGCACTTGAGATATGTGCAGTGGGTGGTCTCCCCCTCAGTCTTACTTTGAGCTGCTGTTACTCTAGTCCTTTAAGTCATTCCTCATATGGCATG CTTTTCTTACCTGTCACATCTTGGCCATCCTCCTCTAGACAAAACCAGCCTTTAAAATATCATGTCCAGGCCTGGAAAGAATACAAATCCAGTGCAAAAT TAAACCATTAGTTCTTGATGATAACCTAGCATTAATACTTACAGTATTTTCTTTTTGTAGGAGTTTTATCCCTTGGTTCACTTGAGTGTGCAAGTCATTA AATCCTCATCATTTTAGGGTTGCCAGTGATATTCAGTGTTTAGAGTGGTTCATTCCCTTAATATATACTACCTCTGTCTGTTAATTCTTTCCTAACATGA CATGTAGCTCTCCATGGTCCTCCCTCTGAAACACCACATGCTGTTTAAACTAGAAGCTGTAATTCAAGATCCCAATTCCACCAGGTGCAGTGGCTCATGC CTGTAATCCCAGCACTTCAGGAGGCCGAGGTGGACAGATCACGAGGTCAGGAGTTCGAGACCATCCTGGCTAACACGGTGAAACCCAATCTCTACTAAAA ATACAAAAAATTAGCCAGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGC AGTGAGCCTTGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAATAATAATAATAAATAAATAAAAAATCCCAATTA CAGAACAGGAGATATGTTTCCTCTGACAAAACCCCATTTTTAGAGTGTATAAAATTCTGTCTTTCATTTCCAACCATTTTTCAAGAGAAGCTGCTACTAT CTTGAGACTTCGTATTATCATGGGAGTACTGTAAGTTCAGTTCTCAGGGAATGCTAAATTAGAGTAATAAGTTTTATATCCTTCATTCTGGGAGAGGAAA TCAACATAAGGTGTTGACTAATTGATTATCCTGGAACATTTTGAATATTGGGGAAGGAAGATGATACTTCTTTCTCAAGAAAAGAAAATTGGATTATTAG GAATACATCTTGACCCTTTTCCACTCAATAGACCAGGGAAAGGGGTTACAGAGAGCCTCCTCAGATCTGTTTGTGCCTTTCAAAAGTACTGGGGGCAGAT TCTCAAAACTCTTAGATTGGTGTTGCATCCCTGCCACTTCACATGACCCTTCCATGTTAAAGCTGACTTTTCTTGCCAGAAAGTTTTCCTTGTGACAAGA AATTTGCAAGCTTTTCAATCTCAGGAATACTGGATTCTATAGCCAAGAACTCATGAAAGTAAGTGTAAACTATCCTAGGTAATTTCAGGTACTTTCTCTT ATGCAATTAATTTTATTAACTGATTTCTGGTCTATCTCCAGAGATAAAATACCATTCCTTCACAACTGTATTGTCTGGAAGCCCCATGAGATGGTAATTA TAGGCCTTCTACTAGCCAGCAGTTCTCTCTGGATACTGGCATCAGCAGGTCTCCTTTTTCTTGTGCTGCTTGGACAGGTACCTACTGCTGGCCTCTTCAG TGGCCACAATCCTCAGTCCTCACCTGCTGGTTTGGAGACTCATGAGCACCCCAGGCAGCTCAAGCTGAATAAATAGCTGCAGACATGGCCAACAACATGG GGCTCAGGTCTGTCACTTAACTTAGAGTCTTTACATGAAATATCAGAATGGGAAAGAGAATGTTCCTGGTAAAACTCTGTTTTCATTAATTTGTTATTTT TCAAAAACCGAGCCACACCTTTGGAAGTAATGATTTGGCCATTCCAGAGATTCTGGGGCTAAAGTTTGTTTTTCCAGGGCTGCTGATCCTTTTCCAGATA GCTCCAGAGTATGATGACCCCAGCCCCATCCCAATCTCTAGCGAAAGGGTTATGCAAATCTCAGGGTGTTGCCTCTAAAGAATCTAAAGAATAGACATGC TTTGGGCTTACTCAGTGTACCAGATTCTCTAGTGGGCCATTCTCATTTGATGTTCCCTAGAACCTCCCTGTCTTCCAACTGCAGGATGTGTTTACTTCTC TTCTGGGCTTCCCCTGGTTTCTGTCCTAGTTCCCACCCCAAGTTTAAGAAGACTTAGATTCATTTATTGCTATCTGAGGCCACTAGTGAGATTTCAGATC TCTCTTTTGCAACATTTTACCCATTTCCCTTCCCCAAACCATGTGCTTATTAGATGGTTCCACTCAGGAAGCAAGGAAGCTAAAACTCAAGTTAATGGTC TGTGGATCCCACGAAAGTGTGTGTAAACTACTGACTGTTTCTCCACTAGAGGCATTTAATTGAGCCAAAGATGATGGAAGAAGAAACTCTCAAAGCCATG TACTTTGTTAGGTGTCTGGATTTTTGGCCTGTTTGCAGCCTCTCCTAGCCACAGACAGACACTGTCTCCTCTCAGAGAAAGGCCAGTGTTTCGGTCCAGG CCACTGGTGAGTGTCGGCACCCTTGAGGTGGGCATGGAGTGAGCAGAAGAAGCCTGGAGAAGAGAGAACTATTTAAAAGTGTTGCCAGTTATTCAGCTTC CAGGCGGCTTTGCACCTCCAAAGGTGCAAAAAGGAAAAAGAAAGCAGAAAGGATTCAGCATTTAAGCAGAAAGAAAAGGGAAATTCTACTCTACCAGATG AGCCACTGGTTCCACTGGAGCTTATCAGTGAAGTAACACTGCAGGAGCCCTGGTATCCTTCCCTCAGAGATATCATCAGGGGCCCTCAAACCCCATTGTT TATGCCAGCACTGACCGCACTTTAAGCACACACTTACCAATCAGAGGTCGTGTAATTGGCCTAAATCTAGGCCCAGTTATTACTACAAATCTTAGTCACC ATACTCTCTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGGGATCCTCTCACCTCAGCTCCCGAGCA GCTAGGACTGCAGGTGTGCACCACCATGCCCAGCTAATTTTTGAATTTTTTTGTAGAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTGAAGCTGCTG GGCTCAAGCAATCCACCTGGCTGGGCCTCCCAAAGCGATAGGATTACAGGCGTAAGGGCCCACGCCCAGCCTACCATACTGATTTTCAAGGCAGGGTCTA ACCCTTCATAAGATGTGAGTTCTTCCAACCCAATAAGCAGGCAGCTTTGAGGACAAAAAGGCAACATTAAAAGATAAGACCCTAGAAGTCAGAACATCTG TATTCCAAGGCCACCCCTTCTCCTTTTAGTCATGTGACTTTGGGCAGGTCACCCTCCCTGTCTGTAAAATGAGGTTGGACTGGATAATCTTTATGTGCCC TTTCCTTTTGGCTTAAAATTCTGTGATTTATTCATTCTTAGGAAGATCAGCATATTTATTGGGATTTCTGCTTCAAAAATTCTTTCTAACCTCAAAAATC CAAGTCCAGAATTTTTTGTTTTCTTCTGGATTTAAACTGTTTAATATGAGCACATCAAGGTTGACTTCTCATCCTTTTTGGGAAGTGAATTTAATATTGA GGGTAATTGAATGATGTTGCAATGGCTTTCCCTCCTGCTGGCTTGGTAAGAATATTAAAGCCTGCAGAGGTGGAAATTGGAGCTCATGGAGAAATGGATA GAAAGCAATTTGTTGCAGGCAGCCTTTGGACAAGTTGTTTTAATAGGAAATAGACCTGCTGCTTCATAGGTTTCCTCAACCACCTTTCCTCAGCTTTCTT AAAATGGGATCTACATTGGCTCTTCACACCCAAATAGCAGACTAATCGTTTTTCTGCTTAGCACCGTCTGGTTCATTGTCTTGAACTCTGCCTTACAGCA GCAAGAAAATTTTCCTCGACAAGAACCTCAATCTTTAGTTCCATTGAGCTCCCCCTCTGGATTTTGGACTTACCAGAAGTAGGAGGTTCTGATACCATTC AAGATGGTCTTTCCTTCAAAGCAGGTCTGAAGAGGAGACTACCAAAGCAGTGTTTACAAACCCAGAGTCCACACAACCATATTGCATAGAACAGCACTTG GCTTTCACAAGCCTCCTACAGGACCTGGTGTAATTGGAGTGAAAGGGCAGAGACCCTGGAAGTGGAGGTGGCTGTGTGCTGCGATGGGAAGAAGGCAGAA GGCCCAGGGGCTTTGGACATAGAGCAGGGTGGAAGCTGCAAGTACTGGGAAGGAAGAGAGTTTCACAGAAACAAAGCTTTGTCACACAGAAATGAGTTCT GTCTCACTGGTGACTTCATCCCTCAGGCTCCAGCTGAGCAGAGATTTTAATCAGCTTCCTTAATGGGTATTGACACTGCTCAGGAAGCAGTAGACCCTGT CAGGGACAGCTATTGATCTTTTGTGTTCTGATTAGATTGGAAAATAGATCAACTTCATTGTAGTCCAGGAACTGTTGGTCACAGCTACTAGGAATGAGGT GATTTCTGAGGGCTGAGAAAAAACACAGAATCTTGGCCAGCAGCCAGCAGCTGCATGGTGAAAGATGCATTCACTTCTCCTTTGAGAGTTGGGGTTGAGG GCAAACATAGAACCCAGGTTTGGCTTACAACCCAGTGTCCCGGAAGCCCTCCTTCGGGAGAACTGTAAGTAAGAGGTGGGTGTGTCTAAAGACAATACCA TTAATGAATGTTCTGGCCTTACCTAAAAAGGTTTAGCAATTTGGGGATAACTCTTGGATCTAGCTTATGTGCGTTCACATGCACATTTGCTAGCCCAGAG CTTTTAAAATGAGGTCTGGCATATACTTGATTACAAATGAAAACTCAGAAACCAATTTTATTTATTAAATCATATCTTTTGTTTTTCCCCCTCCCTTCTA ATCCCCCAAAGGACCTATTTGAGCTGTTCCCCAATTCATCTGCTTATTTTGGACCATGAATCTGCCAGAGTGATATTTTCTGTTATTTCTCCTCCAAATT TTTCCCTGATGTTTCCAATAAAGATTTACTTGGGTGGCCCCTTAAGGTGACATCAGGATGCTCTTATGTCCTTCCAGAATAAGCATACACTTCACTCCTC TCCCTTTCATCTCCCTCTGCATTCTTAATTCCTTGCTTTTCTCACTTGGAGCCGAGGGTGCTTTAGAGAGGTGGTTTTCCATGAATCAGCCAAGATTCCT GTAGAAGTTGGGTATACCAACCACCACCACCACCGCCCCCTATTCCAGTTTCAAAGCTCCTCGGCTATGCTAATGTCCCCTCAGAGATGAGGTTTGACTT TTAGGCCCGTATGACTCCTCCATAGCCTGGCCAAGGAGACCATGAGTAGCCATGTCTGGTTTACTCTTTATCCTGAGACTGTTTATAGCTTAAAACAGAA GTGTGTCTTCCCAGCACAAACCTAATCAATCAGTGTATCAGTGCATCTGGTGGCAACAGCTCAGCCCATTCAAAGAGCAAGGATTCAGGAAAGGCACACT GATGGTGGGGAGCCTCTTAAGAGCCTCTAATGTTCTCCCAAAACCAGAGTTGAGAGTCGGAGTGCCAGTCGTCGGGGCCCACTATTCCTGAATAAGGGAC ATGCAAGGGCCAGAAGTAGCTTGACTCTCGCCTAAATATCTGTGCCTTTGCCTGTCCTTTCTCCCACTCTACTGAAACCCGGAACAGATTCCCGCTTGCC TTCTGATGAAGAGAGGTTAGGTAAAGAGAGTTTGGAGGAAAAAAGACACCAGGAGGCAGGCTGCGGGGTAGGAGAGGGTTCTGAGAGGAGGCAGCAATCC AGAATACCTCCTTTTCTAGCCAGCATCCCTTGAACTTTTGAAAGGTTGTGCCTACCACTGGCTGGCACACCAGGGCAATGATTTCCCTGCAGAAGGAAGG AAAGAATGTTTCACCCTTGCATCCTTCTTGGAGAAGCTACAGCCTGTGCTCAGTTGAGTGGTTCACACTCAGACTTTGGCTTTATGGTTTTCCTTCCTCC TTGTCTTTGCCCTGACCTTGATCAACAGGGGTGAAAAGAACCACCCTGAGGTTTCCATGCCTCTCCCATTTTAGTGGTAGCATTTTGTGTCTTTACTCCA CCCTTCACCCTAGTTCCACCAAGGTTCACACACCAGATGTAACTGTTTTTCAGCTGAGTTGTATGGATTAACTTCAGTCCACTGTAAATACACCTGGGAT GGGGTGGGGTTGGGGTTGTTTAGGGAGAAGCAGCCAGACTTGCTTTGTGAACTGAATGTATTTTTATGCAATTTTGAGTGGCCTTTCAACCCTAAGATGA ATGGTTTTGTTTTACTGGTTGTTGTTATATAGTTTTGAGTATTCTGTGTTTGAAAGTTTGGGAATAATAATATTCACTTCTATATGATGCCTGTAAACAC AACAGTATTTATAAATGAGTAAATAAAACTGTGTTTTAACTTTG

refseq_PPP1R12B.F1 (forward primer)
refseq_PPP1R12B.R1 (reverse primer)
Single exon skipping

Frame 0

VAGTIS*NGLQCLEKDSQRSGHLFVENWASGKV AAQVCGKVCLR*LDLLSPGMI*SGNRVPCHSWFY GNQRHRKLIWVFWGIETSLCHSLLVLCVWMLTP VC*VETSASAGPGMSEAAGPI*LLYGMRKQSLY GKHAPDKLGRHEGLLKVSP*QTFKKQKGHSAGRG QRGKLRSSLVRSPQTLKGLRGALRSMSPQQFQQ QKLGRASSPGAGVWMKSLSVIA*GAQLSQTNPP RQHLLLRQDPHSTPVPTCYGQIDFQSLILRVQRL PQTLQLQRKWTKMRMKKQIWMSSPLRGCPSERG GGPRNDEEAQASISGQRMRMKLMALKRSKKRGM KDFLGWNREVVILQPVILTVTGLQQEPVGRPGRP A*PP*PAV*KKTATEIIKNSMRVL*LKTKN*KQ NFRKPS*S*QI*SPSLRRWPSRNKKRPLTDHQC WRWRNGRGEPWSAKCQKWRKK*RTSTS*NRFKP* SR*TSNCRLRTGP*PEWWPDSRSPSSPRTPRSS SSCPYSPTHFPPPLLQVLTELKSDNQRLKDENG ALIRVISKLSK*ARLQIYEERKGQHLLPPPLFSS PCLPTKRNGCFGGRTLLSITLFSHLYTLYIFSA LSMPCSSKPLSQVL*QF*LKHDCGNSSHLENAL GSTPGSAVDPSTSCCSATLSTLDLVQTCKTSTLI SILQLFTLTQCPLI*VSLVVATPGS*LGCQEKQ QDVELIIRCPLEWLASKVTVTALRRSILLHLSG TDFYFFCQHPVISLTSFNPYSSLIPSHFSKAQMA LASFIPFLSILLYFSLPHPLTQWYKS*DRAPDL SCLWPLWEVIILETRKSSLWCLGGSTTACSLEG RLWHKCQLIVFVSHLSSPFKVIFFIRKFGL*ILH SASLP*PCFPLFALTPASNEK*SQCKEE*EVGR GDC*EMD*EVEAGWKDTYGESQVSEATCNIVTK KMEDSSLLGCENSGEFDYFQWLDLAERFTFLEIN RGNGT**RFNGMKYFQPIDESHGSLEWQDPEVI RSSFLLLCHRDPCYHSFHPWAWSGSLWWLCIYY SKVGQL**RESFSSYQLKSACGFSL*SRSTICNS LTALEICAVGGLPLSLTLSCCYSSPLSHSSYGM LFLPVTSWPSSSRQNQPLKYHVQAWKEYKSSAK LNH*FLMIT*H*YLQYFLFVGVLSLGSLECASH* ILIILGLPVIFSV*SGSFP*YILPLSVNSFLT* HVALHGPPSETPHAV*TRSCNSRSQFHQVQWLM PVIPALQEAEVDRSRGQEFETILANTVKPNLY*K YKKLARRGGRRL*SQLLRRLRQENGVNPGGGAC SEP*SRHCTPAWVTEQDSISKKIIIINK*KIPI TEQEICFL*QNPIFRVYKILSFISNHFSREAATI LRLRIIMGVL*VQFSGNAKLE**VLYPSFWERK ST*GVD*LIILEHFEYWGRKMILLSQEKKIGLL GIHLDPFPLNRPGKGVTESLLRSVCAFQKYWGQI LKTLRLVLHPCHFT*PFHVKADFSCQKVFLVTR NLQAFQSQEYWIL*PRTHESKCKLS*VISGTFS YAINFIN*FLVYLQR*NTIPSQLYCLEAP*DGNY RPSTSQQFSLDTGISRSPFSCAAWTGTYCWPLQ WPQSSVLTCWFGDS*APQAAQAE*IAADMANNM GLRSVT*LRVFT*NIRMGKRMFLVKLCFH*FVIF QKPSHTFGSNDLAIPEILGLKFVFPGLLILFQI APEYDDPSPIPISSERVMQISGCCL*RI*RIDM LWAYSVYQIL*WAILI*CSLEPPCLPTAGCVYFS SGLPLVSVLVPTPSLRRLRFIYCYLRPLVRFQI SLLQHFTHFPSPNHVLIRWFHSGSKEAKTQVNG LWIPRKCV*TTDCFSTRGI*LSQR*WKKKLSKPC TLLGVWIFGLFAASPSHRQTLSPLRERPVFRSR PLVSVGTLEVGME*AEEAWRRENYLKVLPVIQL PGGFAPPKVQKGKRKQKGFSI*AERKGKFYSTR* ATGSTGAYQ*SNTAGALVSFPQRYHQGPSNPIV YASTDRTLSTHLPIRGRVIGLNLGPVITTNLSH HTLSPRLECSGVISAHCNLHLPGSRDPLTSAPEQ LGLQVCTTMPS*FLNFFVEMGFCHVAQAGLKLL GSSNPPGWASQSDRITGVRAHAQPTILIFKAGS NPS*DVSSSNPISRQL*GQKGNIKR*DPRSQNIC IPRPPLLLLVM*LWAGHPPCL*NEVGLDNLYVP FPFGLKFCDLFILRKISIFIGISASKILSNLKN PSPEFFVFFWI*TV*YEHIKVDFSSFLGSEFNIE GN*MMLQWLSLLLAW*EY*SLQRWKLELMEKWI ESNLLQAAFGQVVLIGNRPAAS*VSSTTFPQLS *NGIYIGSSHPNSRLIVFLLSTVWFIVLNSALQQ QENFPRQEPQSLVPLSSPSGFWTYQK*EVLIPF KMVFPSKQV*RGDYQSSVYKPRVHTTILHRTAL GFHKPPTGPGVIGVKGQRPWKWRWLCAAMGRRQK AQGLWT*SRVEAASTGKEESFTETKLCHTEMSS VSLVTSSLRLQLSRDFNQLP*WVLTLLRKQ*TL SGTAIDLLCSD*IGK*INFIVVQELLVTATRNEV ISEG*EKTQNLGQQPAAAW*KMHSLLL*ELGLR ANIEPRFGLQPSVPEALLRENCK*EVGVSKDNT INECSGLT*KGLAIWG*LLDLAYVRSHAHLLAQS F*NEVWHILDYK*KLRNQFYLLNHIFCFSPSLL IPQRTYLSCSPIHLLILDHESARVIFSVISPPN FSLMFPIKIYLGGPLR*HQDALMSFQNKHTLHSS PFHLPLHS*FLAFLTWSRGCFREVVFHESAKIP VEVGYTNHHHHRPLFQFQSSSAMLMSPQR*GLT FRPV*LLHSLAKETMSSHVWFTLYPETVYSLKQK CVFPAQT*SISVSVHLVATAQPIQRARIQERHT DGGEPLKSL*CSPKTRVESRSASRRGPLFLNKG HARARSSLTLA*ISVPLPVLSPTLLKPGTDSRLP SDEERLGKESLEEKRHQEAGCGVGEGSERRQQS RIPPFLASIP*TFERLCLPLAGTPGQ*FPCRRK ERMFHPCILLGEATACAQLSGSHSDFGFMVFLPP CLCPDLDQQG*KEPP*GFHASPILVVAFCVFTP PFTLVPPRFTHQM*LFFS*VVWINFSPL*IHLG WGGVGVV*GEAARLAL*TECIFMQF*VAFQP*DE WFCFTGCCYIVLSILCLKVWE**YSLLYDACKH NSIYK*VNKTVF*L

Frame 1

LLVQSHKMGSSV*RRTVRGVATCLLKIGLLGKL LHKCVARCV*DSLTCFHLE*FDLAIEFLAIPGF MEIRGTGS*SGCSGELRQASAIVC*YSVFGC*LQ CAELRHQQVLGLECQKQQVLSDSCTG*GSRVFT ESTLQTSSADTKVYSRCHPNRPSRSRKDIQPVE GREASSGAAS*EAHRH*RA*GEP*EA*ALSSSSN RSWGGPAALGQESG*RAYLSSPEVPSSARQTHH ASISFYVKTLTLHQFPPAMDK*IFSP*F*EFRD YHKHYNCKGNGQK*E*RSRFG*AVL*EAVHPREE AAQGTTKRHRHQFLDKG*G*N*WL*RGQRNVA* KTF*VGIGR**SYNQ*FLR*PGFSKSPSGGPGG PPSHPDQPCRRRQQQRL*KTL*ECSD*KPKTENK TSGSPARASRYKVQA*EGGPAETRKDL*PIISA GDGETGEASLGAQNVRNGGRNEEPPPAKTDSNL EADERATAG*EQGPDPSGGQTLGVHRVLGHPGAL VLAPTLQLTSLLHYSRC*QN*NPTTRG*KMKMV PSSESSANCPSRLGSRFMRKERDSICCPHPSFP VLAFQPKEMDVLVEGHFFLSPSSVTSIHSTFSLH FQCPVLPNPYPKFYDSFN*SMIVVIRAIWRMLW GVHQAQLWTPQLPAAQLLCPHWIWSKHVRLLP* SVSFSFLH*PSVL*YR*VLW*PLQDPDWGAKRNS RMLN*SSDALWNG*HPR*Q*LH*GALFFFTSQE LTFIFSVNTQ*SP*LVLTLIPPSYLAISPRRKW PWLHLFLSFLSFYIFPFPTPSLNGIKARTEHLTS VVFGHCGKSLFWRQENHHSGALVAAPLPAPWKV DYGISVSSLFSSPTYLPPSK*FSL*ENLGSEYS ILPHFLDLVFLSSP*HLLLMRNEVSARRNERWGG EIVERWTRKWKQAGKTHMAKVKYLRPLATL*QR RWKIAAYWAVRIVVNLIISSG*I*QRDLLS*KL IGEMALNRGLME*STFNPLMRVMEV*SGKTQRSL GPAFYYCVTGTPATTAFTHGHGQVASGGYAFIT QKLGNSNNERVFPHIS*SLPVDSPCSPDLLSAT L*RHLRYVQWVVSPSVLL*AAVTLVL*VIPHMAC FSYLSHLGHPPLDKTSL*NIMSRPGKNTNPVQN *TISS***PSINTYSIFFL*EFYPLVHLSVQVI KSSSF*GCQ*YSVFRVVHSLNIYYLCLLILS*HD M*LSMVLPLKHHMLFKLEAVIQDPNSTRCSGSC L*SQHFRRPRWTDHEVRSSRPSWLTR*NPISTK NTKN*PGVVAGACSPSYSGG*GRRMA*TREAELA VSLDHATALQPG*QSKTPSQKK****INKKSQL QNRRYVSSDKTPFLECIKFCLSFPTIFQEKLLL S*DFVLSWEYCKFSSQGMLN*SNKFYILHSGRGN QHKVLTN*LSWNILNIGEGR*YFFLKKRKLDY* EYILTLFHSIDQGKGLQRASSDLFVPFKSTGGR FSKLLDWCCIPATSHDPSMLKLTFLARKFSL*QE ICKLFNLRNTGFYSQELMKVSVNYPR*FQVLSL MQLILLTDFWSISRDKIPFLHNCIVWKPHEMVI IGLLLASSSLWILASAGLLFLVLLGQVPTAGLFS GHNPQSSPAGLETHEHPRQLKLNK*LQTWPTTW GSGLSLNLESLHEISEWERECSW*NSVFINLLF FKNRATPLEVMIWPFQRFWG*SLFFQGC*SFSR* LQSMMTPAPSQSLAKGLCKSQGVASKESKE*TC FGLTQCTRFSSGPFSFDVP*NLPVFQLQDVFTS LLGFPWFLS*FPPQV*EDLDSFIAI*GH**DFRS LFCNILPISLPQTMCLLDGSTQEARKLKLKLMV CGSHESVCKLLTVSPLEAFN*AKDDGRRNSQSH VLC*VSGFLACLQPLLATDRHCLLSEKGQCFGPG HW*VSAPLRWAWSEQKKPGEERTI*KCCQLFSF QAALHLQRCKKEKESRKDSAFKQKEKGNSTLPD EPLVPLELISEVTLQEPWYPSLRDIIRGPQTPLF MPALTAL*AHTYQSEVV*LA*I*AQLLLQILVT ILSRPGWSAVV*SQLTATSTSQAQGILSPQLPS S*DCRCAPPCPANF*IFL*RWGFAMLPRLV*SCW AQAIHLAGPPKAIGLQA*GPTPSLPY*FSRQGL TLHKM*VLPTQ*AGSFEDKKATLKDKTLEVRTS VFQGHPFSF*SCDFGQVTLPVCKMRLDWIIFMCP FLLA*NSVIYSFLGRSAYLLGFLLQKFFLTSKI QVQNFLFSSGFKLFNMSTSRLTSHPFWEVNLIL RVIE*CCNGFPSCWLGKNIKACRGGNWSSWRNG* KAICCRQPLDKLF**EIDLLLHRFPQPPFLSFL KMGSTLALHTQIAD*SFFCLAPSGSLS*TLPYS SKKIFLDKNLNL*FH*APPLDFGLTRSRRF*YHS RWSFLQSRSEEETTKAVFTNPESTQPYCIEQHL AFTSLLQDLV*LE*KGRDPGSGGGCVLRWEEGR RPRGFGHRAGWKLQVLGRKRVSQKQSFVTQK*VL SHW*LHPSGSS*AEILISFLNGY*HCSGSSRPC QGQLLIFCVLIRLENRSTSL*SRNCWSQLLGMR *FLRAEKKHRILASSQQLHGERCIHFSFESWG*G QT*NPGLAYNPVSRKPSFGRTVSKRWVCLKTIP LMNVLALPKKV*QFGDNSWI*LMCVHMHIC*PR AFKMRSGIYLITNENSETNFIY*IISFVFPPPF* SPKGPI*AVPQFICLFWTMNLPE*YFLLFLLQI FP*CFQ*RFTWVAP*GDIRMLLCPSRISIHFTP LPFISLCILNSLLFSLGAEGALERWFSMNQPRFL *KLGIPTTTTTAPYSSFKAPRLC*CPLRDEV*L LGPYDSSIAWPRRP*VAMSGLLFILRLFIA*NR SVSSQHKPNQSVYQCIWWQQLSPFKEQGFRKGTL MVGSLLRASNVLPKPELRVGVPVVGAHYS*IRD MQGPEVA*LSPKYLCLCLSFLPLY*NPEQIPAC LLMKRG*VKRVWRKKDTRRQAAG*ERVLRGGSNP EYLLF*PASLELLKGCAYHWLAHQGNDFPAEGR KECFTLASFLEKLQPVLS*VVHTQTLALWFSFL LVFALTLINRGEKNHPEVSMPLPF*W*HFVSLLH PSP*FHQGSHTRCNCFSAELYGLTSVHCKYTWD GVGLGLFREKQPDLLCELNVFLCNFEWPFNPKM NGFVLLVVVI*F*VFCV*KFGNNNIHFYMMPVNT TVFINE*IKLCFNF

Frame 2

CWYNLIKWAPVFREGQSEEWPPVC*KLGFWESC CTSVWQGVSEIA*PAFTWNDLIWQ*SSLPFLVL WKSEAQEVDLGVLGN*DKPLP*FVSTLCLDANS SVLS*DISKCWAWNVRSSRSYLTPVRDEEAESLR KARSRQARQTRRSTQGVTLTDLQEAERTFSRSR AERQAQEQPREKPTDTEGLEGSPEKHEPSAVPA TEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTT PASPSTSRPSLYTSSHLLWTNRFSVPDSESSET TTNTTTAKEMDKNENEEADLDEQSSKRLSIRER RRPKERRRGTGINFWTKDEDETDGSEEVKETWHE RLSRLESGGSNPTTSDSYGDRASARARREAREA RLATLTSRVEEDSNRDYKKLYESALTENQKLKT KLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVL EMEKRERRALERKMSEMEEEMKNLHQLKQIQTL KQMNEQLQAENRALTRVVARLSESIESSDTQEL *FLPLLSNSLPSSTTPGVNRTEIRQPEAER*KWC PHQSHQQTVQVG*APDL*GKKGTAFAAPTPLFQ SLPSNQKKWMFWWKDTSFYHPLQSPLYTLHFLC TFNALFFQTPIPSFMTVLIEA*LW*FEPSGECSG EYTRLSCGPLNFLLLSYFVHIGFGPNM*DFYPN QYPSAFYINPVSSDIGESCGSHSRILIGVPRET AGC*IDHQMPSGMVSIQGDSDCIEALYSSSPLRN *LLFFLSTPSNLPN*F*PLFLPHT*PFLQGANG PGFIYSFPFYPFIFFPSPPPHSMV*KLGQST*P QLSLAIVGSHYSGDKKIITLVPWWQHHCLLPGR* TMA*VSAHCFRLPLIFPLQSDFLYKKIWALNTP FCLTSLTLFSSLRPDTCF**EMKSVQGGMRGGE GRLLRDGLGSGSRLERHIWRKSSI*GHLQHCDKE DGR*QPTGL*E*W*I*LFPVVRFSREIYFLRN* *GKWHLIEV*WNEVLSTH**ESWKFRVARPRGH *VQLSIIVSQGPLLPQLSPMGMVR*PLVAMHLLL KSWATLITREFFLISAEVCLWILLVVQIYYLQL FNGT*DMCSGWSPPQSYFELLLL*SFKSFLIWH AFLTCHILAILL*TKPAFKISCPGLERIQIQCKI KPLVLDDNLALILTVFSFCRSFIPWFT*VCKSL NPHHFRVASDIQCLEWFIPLIYTTSVC*FFPNM TCSSPWSSL*NTTCCLN*KL*FKIPIPPGAVAHA CNPSTSGGRGGQITRSGVRDHPG*HGETQSLLK IQKISQAWWQAPVVPATQEAEAGEWREPGRRSL Q*ALITPLHSSLGDRARLHLKKNNNNK*IKNPNY RTGDMFPLTKPHF*SV*NSVFHFQPFFKRSCYY LETSYYHGSTVSSVLREC*IRVISFISFILGEE INIRC*LIDYPGTF*ILGKEDDTSFSRKENWIIR NTS*PFSTQ*TRERGYREPPQICLCLSKVLGAD SQNS*IGVASLPLHMTLPC*S*LFLPESFPCDK KFASFSISGILDSIAKNS*K*V*TILGNFRYFLL CN*FY*LISGLSPEIKYHSFTTVLSGSPMRW*L *AFY*PAVLSGYWHQQVSFFLCCLDRYLLLASS VATILSPHLLVWRLMSTPGSSS*INSCRHGQQHG AQVCHLT*SLYMKYQNGKENVPGKTLFSLICYF SKTEPHLWK**FGHSRDSGAKVCFSRAADPFPD SSRV**PQPHPNL*RKGYANLRVLPLKNLKNRHA LGLLSVPDSLVGHSHLMFPRTSLSSNCRMCLLL FWASPGFCPSSHPKFKKT*IHLLLSEATSEISD LSFATFYPFPFPKPCAY*MVPLRKQGS*NSS*WS VDPTKVCVNY*LFLH*RHLIEPKMMEEETLKAM YFVRCLDFWPVCSLS*PQTDTVSSQRKASVSVQ ATGECRHP*GGHGVSRRSLEKRELFKSVASYSAS RRLCTSKGAKRKKKAERIQHLSRKKREILLYQM SHWFHWSLSVK*HCRSPGILPSEISSGALKPHC LCQH*PHFKHTLTNQRSCNWPKSRPSYYYKS*SP YSLAQAGVQWCDLSSLQPPPPRLKGSSHLSSRA ARTAGVHHHAQLIFEFFCRDGVLPCCPGWSEAA GLKQSTWLGLPKR*DYRRKGPRPAYHTDFQGRV* PFIRCEFFQPNKQAALRTKRQH*KIRP*KSEHL YSKATPSPFSHVTLGRSPSLSVK*GWTG*SLCA LSFWLKIL*FIHS*EDQHIYWDFCFKNSF*PQKS KSRIFCFLLDLNCLI*AHQG*LLILFGK*I*Y* G*LNDVAMAFPPAGLVRILKPAEVEIGAHGEMD RKQFVAGSLWTSCFNRK*TCCFIGFLNHLSSAFL KWDLHWLFTPK*QTNRFSA*HRLVHCLELCLTA ARKFSSTRTSIFSSIELPLWILDLPEVGGSDTI QDGLSFKAGLKRRLPKQCLQTQSPHNHIA*NSTW LSQASYRTWCNWSERAETLEVEVAVCCDGKKAE GPGALDIEQGGSCKYWEGREFHRNKALSHRNEF CLTGDFIPQAPAEQRF*SASLMGIDTAQEAVDPV RDSY*SFVF*LDWKIDQLHCSPGTVGHSY*E*G DF*GLRKNTESWPAASSCMVKDAFTSPLRVGVE GKHRTQVWLTTQCPGSPPSGEL*VRGGCV*RQYH **MFWPYLKRFSNLGITLGSSLCAFTCTFASPE LLK*GLAYT*LQMKTQKPILFIKSYLLFFPLPS NPPKDLFELFPNSSAYFGP*ICQSDIFCYFSSKF FPDVSNKDLLGWPLKVTSGCSYVLPE*AYTSLL SLSSPSAFLIPCFSHLEPRVL*RGGFP*ISQDS CRSWVYQPPPPPPPIPVSKLLGYANVPSEMRFDF *ARMTPP*PGQGDHE*PCLVYSLS*DCL*LKTE VCLPSTNLINQCISASGGNSSAHSKSKDSGKAH *WWGAS*EPLMFSQNQS*ESECQSSGPTIPE*GT CKGQK*LDSRLNICAFACPFSHSTETRNRFPLA F**REVR*REFGGKKTPGGRLRGRRGF*EEAAI QNTSFSSQHPLNF*KVVPTTGWHTRAMISLQKEG KNVSPLHPSWRSYSLCSVEWFTLRLWLYGFPSS LSLP*P*STGVKRTTLRFPCLSHFSGSILCLYS TLHPSSTKVHTPDVTVFQLSCMD*LQSTVNTPGM GWGWGCLGRSSQTCFVN*MYFYAILSGLSTLR* MVLFYWLLLYSFEYSVFESLGIIIFTSI*CL*T QQYL*MSK*NCVLTL