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Sequences

Sequence NM_181042

TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCA GGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAG ACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAG AAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTG AATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGG GCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCA TCAGGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCA TTGCCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGG CTCTCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATG AGGACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCACTAGCAAGTATTACCGTA ATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCACGCTA TGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAAC CAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGA TCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAA TTCAGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATG ATCTCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAG CTCGAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAAT GGACTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAGGCAC TATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGATGATG ACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGGTCTA TGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACT ATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTA ATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGA TGAGGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGC TACAGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATC GCTACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGT AGAACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTTGCAT AATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGTGAAG ATTCCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCTATGT GGAACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGGTGAAAAATGGTTGTATGGCTGTTGGTTTTAC CGACCAAATGAAACATTCCACCTGGCTACACGAAAATTTCTAGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAAGTTCCAGTTAGTAAAATTCTAG GCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCTGTGAATCACGGTATTCTGCCAA AACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCTGCCTGTGGTTCGCGTGGCCTCT GTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTTAACTTGGAAAAGGAAAAAGAAG ATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGAAGGTTGGCGACTGTGTCTTCAT CAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTATGGCCCCATCTTCATTCACCCA GAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCCATGACATGTATTCTCGGAAAGT GTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGAGCCGCTACAATGAGAGCGACAA GCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAGAAAACCAATTGTTCCTCAGAAG GAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGATATTGAAGAGATGGGAGAAGAAG ATAGTGAGGTCATTGAACCTCCTTCTCTACCTCAGCTTCAGACCCCCCTGGCCAGTGAGCTGGACCTCATGCCCTACACACCCCCACAGTCTACCCCAAA GTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCTACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAAGGCC CAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGGTGTGATGA ACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACC TCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCAC TCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATT TGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGAT GCTCCGGGACACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATC AGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACA CTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTC ATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTT TCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAA TGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCT TACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAA TATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTG AGTTAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTAT AATGAATTCACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGG TATGCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAA CAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAAT TCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACT AGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACA GTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCT GAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAG AGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCAT CAAGTATTTTAAATAATATTGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTA TTTGGGCAATTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGT TAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACG TGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGC AGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGG GGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTT TTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATT GCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTT TTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTC ATACCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTG TTCATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTGCAAAGTGA

refseq_PB1.F3 (forward primer)
refseq_PB1.R3 (reverse primer)
Single exon skipping

Frame 0

SMGSKRRRATSPSSSVSGDFDDGHHSVSTPGPS RKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGR LLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQ KLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSP EYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDG QDNQGTVTEGSSPAYLKEILEQLLEAIVVATNP SGRLISELFQKLPSKVQYPDYYAIIKEPIDLKT IAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPG SQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRM RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR NKRAVQGGRLSAITMALQYGSESEEDAALAAARY EEGESEAESITSFMDVSNPFYQLYDTVRSCRNN QGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQ IRTKLKNQEYETLDHLECDLNLMFENAKRYNVPN SAIYKRVLKLQQVMQAKKKELARRDDIEDGDSM ISSATSDTGSAKRKSKKNIRKQRMKILFNVVLE AREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPM DLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARH YNEEGSQVYNDAHILEKLLKEKRKELGPLPDDD DMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVY EAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLT IKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMF NNACTYNEPESLIYKDALVLHKVLLETRRDLEGD EDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRC YSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENN RYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAV ELQQFFIKIRDELCKNGEILLSPALSYTTKHLH NDVEKERKEKLPKEIEEDKLKREEEKREAEKSE DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYV EPAEANLQPHIVCIERLWEDSAGEKWLYGCWFY RPNETFHLATRKFLEKEVFKSDYYNKVPVSKIL GKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAK TKSFKKIKLWTMPISSVRFVPRDVPLPVVRVAS VFANADKGDDEKNTDNSEDSRAEDNFNLEKEKE DVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFI KSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHP EETEHEPTKMFYKKEVFLSNLEETCPMTCILGK CAVLSFKDFLSCRPTEIPENDILLCESRYNESDK QMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEE DSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPK SAKGSAKKEGSKRKINMSGYILFSSEMRAVIKA QHPDYSFGELSRLVGTEWRNLETAKKAEYEGVM NQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPP PYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLH SEAYLKYIEGLSAESNSISKWDQTLAARRRDVH LSKEQESRLPSHWLKSKGAHTTMADALWRLRDLM LRDTLNIRQAYNLENV*SHHYVSFI*KHKELWI SSHFSYWGWGEGTKEDNFYCILLYITRPFLYTD TFNKLFQFVCYIKLTLSNTQRFFCICFLRLKPVS *LVVYVDLEFYLFTCCHGTETIRGFCLGLGFLF SWFWVFLYIYIKEQNEKKHTHTRVYRLV*IDNE M*SLS*FTS*RGEYTCVCFMCLNILSHFLQKLFL TDEVLSLKGGYLGFRCLIDTAHLLY*LRGSLQK YVISAVHLSAANVPPGHQEGKKHFFNCAELDIC ELDYGVSDFCRTRAQP*GMFNLGRYV*GYFDLFI MNSQFMPINFR*FKILNLLH*KTLKFVLKKALR YAWR*FIFKHNT*PNMGKRVWN*I*AV*EA*L* TSRLIAFIYKYVLVFLISLLSDVFFLLSFNVVII LNQKFNTF*NIF*I*LVLLNYRRRES*FNKTLT RKTITDPKHLGLVTLSFLYDPTINI*RQHRMAD SRNIVSLGGMFLKPAL**LGDCHCGRASTAVYNL RELISEDAFFLLICYESVPRCLITVLIKS*GQK SVEWKKVSCI*IL*IWEAL*LNCL*STTGFEFA SSILNNIEFKKMYCSSVSVPYC*SESDKSSIPGY LGN*IIMDCIMQSDYFVSRHP*ITPKNMKFSCG *IIYLFHAFILFPLRSG*DFFGEPLKKFFTGGH VGH*KPELSSRLLPSA*RCYRKHRSSQGLP*SSA APAQGITRQALIKFFLKSLCIYFRIMFFCILTW GISLIFRI*DLRSAIFKKEKKIDSRKYK*TIHL FFISFRNCSNVA*KV*WPKCFQNVSSCGEELFIL QTGGLRGTCRFKTVCLSAN*FKRPLTVLVVVFF LSHSPLPMRKN*EGHLFL*NPQIGVDDFELECF HT*LKLGLF*FLYHII*GLRGN*SYNMYVSFFCC SSKAF*SK*IQSLQS

Frame 1

PWVPREEELPPLPAVSAGTLMMGTILCQHQAQA GKGGDFPIFQL*ILLPCAMNSIIPSETIRMNRA DFSVSSSLGHQSEEINQTIMKWFLSPLT**KSNR N*KWKSMMMLIC*LLTSSFFLTMQSPIISQILL NIKPLANSGICTFEQEMSLFRKEKQMTKMMMKM GKTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIH QDVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRP LPRGYRMEATKVFMQWPKI*ISSQKMPKLIMSL ALKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE* GLHPTWLQPD*QVLHTVKAALVKREIPLASITV IKEQYKEVVYQQLQWHFNMAQKVKKMLL*LLHA MKRESQKQKASLPLWMFQILFISFMTQLGVVGIT KGS**LNLFTICLQRKNTLIITSKLKCPYHYNR SEQN*RIKNMKL*IIWSVI*I*CLKMPNAIMCP IQPSTSEF*NCSKLCRQRRKSLPGETISRTETA* SLQPPLILVVPKEKVKRT*ESSE*KSYSMLFLK LESQVQAEDFVTYLWLNHPKRTILIIIKSSWSQ WT*K*LSITSAMTNMLVKRE**KT*S*CSGMPGT IMRRAPRFIMMHISWRSYSRRKGKSWAHCLMMM TWLLPNSS*VGRVAFLLKNQNT*LQCSRN*MRS MKL*RTILIRGVAASVPYF*GFPLDLSCLTTI*L LKSPWTWKKFEVT*WPTSTKILTLWLRTLS*CL IMPVHTMSRSL*STKMLLFYTKSCLKHAETWRE MRTLMSQM*LC*FKSLSTIFLCQS*VIRMMREDA TAIL*QKFLLWIPTFLTNHPLHLT*LGRMLKII ATVGLIYFKSICLKYWNEQEG*IGQIQKYMKMQ *NFSSFLLKFVMNSAKMERFFFHRHSAIPQNICI MMWRKRERKNCQKK*RKIN*NEKKKKEKLKRVK IPLVLQASQAYIAHTARTVALKTACTMLEITSM WNLQRPTYNHISSVLKDCGRIQLVKNGCMAVGFT DQMKHSTWLHENF*KKKFLRVTITTKFQLVKF* ASVWSCLSRNTLSYAQKTSEMRMFLSVNHGILP KPNLLRKLNCGPCPSAQSGLSLGMCLCLWFAWPL YLQMQIKVMMRRIQTTQRTVELKTILTWKRKKK MSLWKCPMVNQVATTLSSSITMTCG*RLATVSS SSPMAWCVLVWAELKKYGFEMELHIFMAPSSFTQ KKQSMSPQKCSTKKKYF*VIWKKPAP*HVFSES VLCCHSRTSSPAGQLKYQKMTFCFVRAATMRAT SR*RNSKD*RGFHSLLKW*MMKFTTSENQLFLRR SHHLCWKRRSSC*KLNLPS*KVEMMILKRWEKK IVRSLNLLLYLSFRPPWPVSWTSCPTHPHSLPQ SLPKAVQRRKAPNGKST*VATSCSAVR*GL*LRP NTQTTLSGSSAAWWGQNGEILRQPRKQNMKV** TKEWPLW*GLQHQVEVHMDNRWEFWGLQGSRHH LHIPAHIQLDPLSYSSQQHPCL*LPHQRPSGFFT QRPT*NTLKDSVRSPTALASGIRHWQLEDATSI CRKNRRAAYPLTG*KAKGPTPPWQMPSGAFEI* CSGTPSTFAKHTT*KMFNHIITFLLYRSIKSCGS VAILVTGGGGKEQRRIIFIAFYCTSQGHFYIRT LLISYFNLFVILS*LYQIHKDFFAYVSFV*NQF HNWLYM*TWSFIFLLVAMELKPLEVFVLAWGFCF LGFGFFYIYI*KNKMKKNTHTQEFTD*FKLIMK CEVCPSLHLREGSILVFVSCA*IS*ATFCKSCF LQMKCFL*KVVI*VLDV**TQHICSINSEAHYRN M*SVLCICLQLMYLLDTRRGKSTFSIVLS*TSV S*TMVSVIFAEHVHNPEVCLI*AGTFKDILIYL **IHNLCL*ISDDLKF*TCYIEKH*SSS*RKH*G MHGGDLFLNITPNLTWVREYGTRYELYKKHNCE QVD*LPSYTSMF*YSLFPYYQMYFFF*VSMLL* FSTRNLILSKIFFKFSLCF*ITGEGNHNLIKRLL ERPLQIPNTWVW*PCLSYMTLQ*TFEGSIGWQT VGTLFHLAACF*NLLYSNWVIAIVVELPLLFII *ES*SQRMLFSF*SAMNQYPDV*LLYLLNHEGKR V*NGKKSLVSRYFKYGRPFNLIAFSQPLDLNLH QVF*IILNLKKCIAVVCQYLIVKVSQINLQFLA IWAIESSWTV*CNQIILFLDILELHQRT*NLVVV KLFIYFMHSFYFP*GLDETSLGSL*KNFSLGAT WVIRSQSSPPGSFPVPRGAIGNIDPARGFPKAV QHRPRASLDRP*LSFF*KACVFILESCFSVY*LG GYR*YLGYKI*GQPSSKKKKKLTQESTSKLYTF FS*VLGTVVMWLRKYNGLNVFKM*VPVEKNCLY CKRGD*GEPVGLKQYVCQPTDLKGL*LFWLLFFF *ATLPFL*GRIERGTYFCKIPKLVLMILSLNVF IPD*NLVYSNFCIISSEVYVVTSLITCMYLFFV VHLKLFNPNKYRVCKV

Frame 2

HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQ EKEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQ TSL*ALH*GTKAKKSTRLL*SGFSAH*LDENPT ETKNGRV**C*FADC*LPASF*QCKVLL*ARFS* I*SRLQTLGFVPSNKK*VCSERRSR*RR***RW ARQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKS IRTSH*RTFSETAF*SAISRLLCNN*GAYRSQDH CPEDTEWKLQKYSCNGQRYRSPRKKCQNL**AW LSSIQGCKFN*KNILYEKG*N*TS*NG*VKSSN EDSIQLGCSQTDRSFTQ*RQPW*REKSH*QVLP* *KSSTRRSFISNYNGTSIWLRK*RRCCFSCCTL *RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE* PRAANS*TFLPFAFKEKIP*LLPAN*NAHITTTD PNKTEESRI*NFRSFGV*SEFNV*KCQTL*CAQ FSHLQASSKIAASYAGKEERACQERRYRGRRQH DLFSHL*YW*CQKKK*KEHKKAANENLIQCCS*S SRARFRQKTL*PIYG*TIQKGLS*LL*NHLGAN GLENN*A*HPQ*QICW*RGNDRRHEADVPECQA L**GGLPGL**CTYPGEVTQGEKERAGPTA**** HGFSQTQAE*EEWHFS*KIKIHDSNAAETK*GL *SCKELY**EGSPPQCHISEASL*I*VA*LLSD Y*KAHGHGKNSKSHDGQQVPRY*LYG*GLCHDV* *CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGGR *GLSCPKCDFADSRAYPQSFCVSHESSG**GKM LQRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K*S LPSA*FISRAYV*SIGTSKKDESDRFRNI*RCS RTSAVFY*NS**TLQKWRDSSFTGTQLYHKTFA **CGEREKGKIAKRNRGR*TKTRRRKKRS*KE*R FLWCCRPLRLTSHIQPGL*L*KQHVPCWRLRLC GTCRGQPTTTYRLY*KTVGGFSW*KMVVWLLVL PTK*NIPPGYTKISRKRSF*E*LLQQSSS**NSR QVCGHVCQGIL*VMPRKLPR*GCFCL*ITVFCQ NQIF*EN*TVDHAHQLSQVCPSGCASACGSRGL CICKCR*R***EEYRQLRGQSS*RQF*LGKGKRR CPCGNVQW*TRLPLL*AAPLQ*HVAEGWRLCLH QVPWPGASSCGQN*KSMGSRWSCIFLWPHLHSP RRNRA*AHKNVLQKRSISE*SGRNLPHDMYSRKV CCVVIQGLPLLQAN*NTRK*HSAL*EPLQ*ERQ ADEEIQRIEEVFTLC*SGR**NLLLQKTNCSSE GAITFAGKEDPVARS*ICRVRRWR**Y*RDGRRR **GH*TSFSTSASDPPGQ*AGPHALHTPTVYPK VCQRQCKEGRLQTENQHEWLHPVQQ*DEGCD*G PTPRLLFRGAQPPGGDRMEKS*DSQESRI*RCDE PRSGPYGRDSSTRWKSIWTTGGSFGASRAAGTT SISRPTSSWTPCHTAANNTHVCSSPTKDPAASS LRGLPEIH*RTQCGVQQH*QVGSDTGSSKTRRPF VERTGEPPTLSLAEKQRGPHHHGRCPLAPSRFD APGHPQHSPSIQPRKCLITSLRFFYIEA*RVVD Q*PF*LLGVGGRNKGG*FLLHFTVHHKAIFIYGH F**AISICLLY*VDFIKYTKIFLHMFPSFKTSF IIGCICRLGVLSFYLLPWN*NH*RFLSWLGVFV FLVLGFFIYIYKRTK*KKTHTHKSLQISLN***N VKFVLVYILERGVYLCLFHVPEYLKPLSAKAVS YR*SAFFERWLFRF*MFNRHSTFALLTQRLTTE ICNQCCASVCS*CTSWTPGGEKALFQLC*VRHL* VRLWCQ*FLQNTCTTLRYV*SRQVRLRIF*SIY NEFTIYAYKFQMI*NFKPVTLKNIEVRLEESIK VCMEVIYF*T*HLT*HG*ESMELDMSCIRSIIVN K*IDCLHIQVCFSIPYFLIIRCIFSFKFQCCYN SQPEI*YFLKYFLNLACAFELQEKGIII**NAY *KDHYRSQTLGFGDPVFLI*PYNKHLKAA*DGRQ *EHCFTWRHVFETCFIVTG*LPLW*SFHCCL*S ERVNLRGCFFPFNLL*ISTQMFNYCTY*IMRAK ECRMEKSLLYLDTLNMGGPLT*LPLVNHWI*ICI KYFK*Y*I*KNVLQ*CVSTLLLK*VR*IFNSWL FGQLNHHGLYNAIRLFCF*TSLNYTKEHEI*LW LNYLFISCIHFISLKVWMRLLWGASKKIFHWGPR GSLEARALLQAPSQCLEVL*ET*IQPGASLKQC STGPGHH*TGPN*VFFKKPVYLF*NHVFLYINL GDIVNI*DIRFEVSHLQKRKKN*LKKVQVNYTPF FHKF*EL**CGLESIMA*MFSKCKFLWRRIVYI ANGGTEGNL*V*NSMFVSQLI*KAFNCFGCCFF FKPLSPSYEEELRGAPISVKSPNWC**F*A*MFS YLIKTWFILISVSYHLRFTW*LVL*HVCIFFLL FI*SFLIQINTEFAK*

Sequence NM_018165

TCCATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCA GGAAAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAG ACTTCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAG AAACTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTG AATATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGG GCAAGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCA TCAGGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCA TTGCCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGG CTCTCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATG AGTAATAAAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCAC GCTATGAAGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAA TAACCAAGGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAA CAGATCCGAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGC CCAATTCAGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAG CATGATCTCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTT GAAGCTCGAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGC CAATGGACTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAG GCACTATAATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGAT GATGACATGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGG TCTATGAAGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCT GACTATTAAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATG TTTAATAATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGG GAGATGAGGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAG ATGCTACAGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAAT AATCGCTACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATG CAGTAGAACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTT GCATAATGATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGT GAAGATTCCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCT ATGTGGAACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGGTGAAAAATGGTTGTATGGCTGTTGGTT TTACCGACCAAATGAAACATTCCACCTGGCTACACGAAAATTTCTAGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAAGTTCCAGTTAGTAAAATT CTAGGCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCTGTGAATCACGGTATTCTG CCAAAACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCTGCCTGTGGTTCGCGTGGC CTCTGTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTTAACTTGGAAAAGGAAAAA GAAGATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGAAGGTTGGCGACTGTGTCT TCATCAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTATGGCCCCATCTTCATTCA CCCAGAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCCATGACATGTATTCTCGGA AAGTGTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGAGCCGCTACAATGAGAGCG ACAAGCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAGAAAACCAATTGTTCCTCA GAAGGAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGATATTGAAGAGATGGGAGAA GAAGATAGTGAGGTCATTGAACCTCCTTCTCTACCTCAGCTTCAGACCCCCCTGGCCAGTGAGCTGGACCTCATGCCCTACACACCCCCACAGTCTACCC CAAAGTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCTACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAA GGCCCAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAATCTTGAGACAGCCAAGAAAGCAGAATATGAAGGCATG ATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCAC CCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGG TGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATA CAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGG AGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCT GAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCGCCAAGCATACAACCTA GAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAA AGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTT GACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTT ACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAAC AAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTA TACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGT TTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTAC CTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGC ACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTCACAATTTATGCCTATAAATTTCAGATGATTT AAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTATGCATGGAGGTGATTTATTTTTAAACATAACACCTAAC CTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGT ATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAA ATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGA CCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACC TGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATC TGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTT AAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATATTGAATTTAAAAAAATGTATTG CAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAATTGAATCATCATGGACTGTATAATGCAATCA GATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCT TAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCC CAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAG TTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAG CCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAA AGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACA GTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGG GGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCA TATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTG CAAAGTGA

refseq_PB1.F3 (forward primer)
refseq_PB1.R3 (reverse primer)
Single exon skipping

Frame 0

SMGSKRRRATSPSSSVSGDFDDGHHSVSTPGPS RKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGR LLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQ KLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSP EYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDG QDNQGTVTEGSSPAYLKEILEQLLEAIVVATNP SGRLISELFQKLPSKVQYPDYYAIIKEPIDLKT IAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPG SQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRM SNKRAVQGGRLSAITMALQYGSESEEDAALAAA RYEEGESEAESITSFMDVSNPFYQLYDTVRSCRN NQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQ QIRTKLKNQEYETLDHLECDLNLMFENAKRYNV PNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDS MISSATSDTGSAKRKSKKNIRKQRMKILFNVVL EAREPGSGRRLCDLFMVKPSKKDYPDYYKIILE PMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNAR HYNEEGSQVYNDAHILEKLLKEKRKELGPLPDD DDMASPKLKLSRKSGISPKKSKYMTPMQQKLNE VYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYL TIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMM FNNACTYNEPESLIYKDALVLHKVLLETRRDLE GDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGR CYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVEN NRYRRLDLFQEHMFEVLERARRMNRTDSEIYED AVELQQFFIKIRDELCKNGEILLSPALSYTTKHL HNDVEKERKEKLPKEIEEDKLKREEEKREAEKS EDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYV YVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWF YRPNETFHLATRKFLEKEVFKSDYYNKVPVSKI LGKCVVMFVKEYFKLCPENFRDEDVFVCESRYS AKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVA SVFANADKGDDEKNTDNSEDSRAEDNFNLEKEK EDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCV FIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIH PEETEHEPTKMFYKKEVFLSNLEETCPMTCILG KCAVLSFKDFLSCRPTEIPENDILLCESRYNES DKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQ KEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGE EDSEVIEPPSLPQLQTPLASELDLMPYTPPQST PKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIK AQHPDYSFGELSRLVGTEWRNLETAKKAEYEGM MGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPP PHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPG GSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVI QQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSA ESNSISKWDQTLAARRRDVHLSKEQESRLPSHWL KSKGAHTTMADALWRLRDLMLRDTLNIRQAYNL ENV*SHHYVSFI*KHKELWISSHFSYWGWGEGT KEDNFYCILLYITRPFLYTDTFNKLFQFVCYIKL TLSNTQRFFCICFLRLKPVS*LVVYVDLEFYLF TCCHGTETIRGFCLGLGFLFSWFWVFLYIYIKE QNEKKHTHTRVYRLV*IDNEM*SLS*FTS*RGEY TCVCFMCLNILSHFLQKLFLTDEVLSLKGGYLG FRCLIDTAHLLY*LRGSLQKYVISAVHLSAANV PPGHQEGKKHFFNCAELDICELDYGVSDFCRTRA QP*GMFNLGRYV*GYFDLFIMNSQFMPINFR*F KILNLLH*KTLKFVLKKALRYAWR*FIFKHNT* PNMGKRVWN*I*AV*EA*L*TSRLIAFIYKYVLV FLISLLSDVFFLLSFNVVIILNQKFNTF*NIF* I*LVLLNYRRRES*FNKTLTRKTITDPKHLGLV TLSFLYDPTINI*RQHRMADSRNIVSLGGMFLKP AL**LGDCHCGRASTAVYNLRELISEDAFFLLI CYESVPRCLITVLIKS*GQKSVEWKKVSCI*IL *IWEAL*LNCL*STTGFEFASSILNNIEFKKMYC SSVSVPYC*SESDKSSIPGYLGN*IIMDCIMQS DYFVSRHP*ITPKNMKFSCG*IIYLFHAFILFP LRSG*DFFGEPLKKFFTGGHVGH*KPELSSRLLP SA*RCYRKHRSSQGLP*SSAAPAQGITRQALIK FFLKSLCIYFRIMFFCILTWGISLIFRI*DLRS AIFKKEKKIDSRKYK*TIHLFFISFRNCSNVA*K V*WPKCFQNVSSCGEELFILQTGGLRGTCRFKT VCLSAN*FKRPLTVLVVVFFLSHSPLPMRKN*E GHLFL*NPQIGVDDFELECFHT*LKLGLF*FLYH II*GLRGN*SYNMYVSFFCCSSKAF*SK*IQSL QS

Frame 1

PWVPREEELPPLPAVSAGTLMMGTILCQHQAQA GKGGDFPIFQL*ILLPCAMNSIIPSETIRMNRA DFSVSSSLGHQSEEINQTIMKWFLSPLT**KSNR N*KWKSMMMLIC*LLTSSFFLTMQSPIISQILL NIKPLANSGICTFEQEMSLFRKEKQMTKMMMKM GKTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIH QDVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRP LPRGYRMEATKVFMQWPKI*ISSQKMPKLIMSL ALKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE* VIKEQYKEVVYQQLQWHFNMAQKVKKMLL*LLH AMKRESQKQKASLPLWMFQILFISFMTQLGVVG ITKGS**LNLFTICLQRKNTLIITSKLKCPYHYN RSEQN*RIKNMKL*IIWSVI*I*CLKMPNAIMC PIQPSTSEF*NCSKLCRQRRKSLPGETISRTET A*SLQPPLILVVPKEKVKRT*ESSE*KSYSMLFL KLESQVQAEDFVTYLWLNHPKRTILIIIKSSWS QWT*K*LSITSAMTNMLVKRE**KT*S*CSGMP GTIMRRAPRFIMMHISWRSYSRRKGKSWAHCLMM MTWLLPNSS*VGRVAFLLKNQNT*LQCSRN*MR SMKL*RTILIRGVAASVPYF*GFPLDLSCLTTI *LLKSPWTWKKFEVT*WPTSTKILTLWLRTLS*C LIMPVHTMSRSL*STKMLLFYTKSCLKHAETWR EMRTLMSQM*LC*FKSLSTIFLCQS*VIRMMRE DATAIL*QKFLLWIPTFLTNHPLHLT*LGRMLKI IATVGLIYFKSICLKYWNEQEG*IGQIQKYMKM Q*NFSSFLLKFVMNSAKMERFFFHRHSAIPQNI CIMMWRKRERKNCQKK*RKIN*NEKKKKEKLKRV KIPLVLQASQAYIAHTARTVALKTACTMLEITS MWNLQRPTYNHISSVLKDCGRIQLVKNGCMAVG FTDQMKHSTWLHENF*KKKFLRVTITTKFQLVKF *ASVWSCLSRNTLSYAQKTSEMRMFLSVNHGIL PKPNLLRKLNCGPCPSAQSGLSLGMCLCLWFAW PLYLQMQIKVMMRRIQTTQRTVELKTILTWKRKK KMSLWKCPMVNQVATTLSSSITMTCG*RLATVS SSSPMAWCVLVWAELKKYGFEMELHIFMAPSSF TQKKQSMSPQKCSTKKKYF*VIWKKPAP*HVFSE SVLCCHSRTSSPAGQLKYQKMTFCFVRAATMRA TSR*RNSKD*RGFHSLLKW*MMKFTTSENQLFL RRSHHLCWKRRSSC*KLNLPS*KVEMMILKRWEK KIVRSLNLLLYLSFRPPWPVSWTSCPTHPHSLP QSLPKAVQRRKAPNGKST*VATSCSAVR*GL*L RPNTQTTLSGSSAAWWGQNGEILRQPRKQNMKA* WVAIRQAFHLCRAQLMALLAWAACSHFTLGGLH PTIFRQVCLASRASHHRV**TKEWPLW*GLQHQ VEVHMDNRWEFWGLQGSRHHLHIPAHIQLDPLSY SSQQHPCL*LPHQRPSGFFTQRPT*NTLKDSVR SPTALASGIRHWQLEDATSICRKNRRAAYPLTG *KAKGPTPPWQMPSGAFEI*CSGTPSTFAKHTT* KMFNHIITFLLYRSIKSCGSVAILVTGGGGKEQ RRIIFIAFYCTSQGHFYIRTLLISYFNLFVILS *LYQIHKDFFAYVSFV*NQFHNWLYM*TWSFIFL LVAMELKPLEVFVLAWGFCFLGFGFFYIYI*KN KMKKNTHTQEFTD*FKLIMKCEVCPSLHLREGS ILVFVSCA*IS*ATFCKSCFLQMKCFL*KVVI*V LDV**TQHICSINSEAHYRNM*SVLCICLQLMY LLDTRRGKSTFSIVLS*TSVS*TMVSVIFAEHV HNPEVCLI*AGTFKDILIYL**IHNLCL*ISDDL KF*TCYIEKH*SSS*RKH*GMHGGDLFLNITPN LTWVREYGTRYELYKKHNCEQVD*LPSYTSMF* YSLFPYYQMYFFF*VSMLL*FSTRNLILSKIFFK FSLCF*ITGEGNHNLIKRLLERPLQIPNTWVW* PCLSYMTLQ*TFEGSIGWQTVGTLFHLAACF*N LLYSNWVIAIVVELPLLFII*ES*SQRMLFSF*S AMNQYPDV*LLYLLNHEGKRV*NGKKSLVSRYF KYGRPFNLIAFSQPLDLNLHQVF*IILNLKKCI AVVCQYLIVKVSQINLQFLAIWAIESSWTV*CNQ IILFLDILELHQRT*NLVVVKLFIYFMHSFYFP *GLDETSLGSL*KNFSLGATWVIRSQSSPPGSF PVPRGAIGNIDPARGFPKAVQHRPRASLDRP*LS FF*KACVFILESCFSVY*LGGYR*YLGYKI*GQ PSSKKKKKLTQESTSKLYTFFS*VLGTVVMWLR KYNGLNVFKM*VPVEKNCLYCKRGD*GEPVGLKQ YVCQPTDLKGL*LFWLLFFF*ATLPFL*GRIER GTYFCKIPKLVLMILSLNVFIPD*NLVYSNFCI ISSEVYVVTSLITCMYLFFVVHLKLFNPNKYRVC KV

Frame 2

HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQ EKEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQ TSL*ALH*GTKAKKSTRLL*SGFSAH*LDENPT ETKNGRV**C*FADC*LPASF*QCKVLL*ARFS* I*SRLQTLGFVPSNKK*VCSERRSR*RR***RW ARQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKS IRTSH*RTFSETAF*SAISRLLCNN*GAYRSQDH CPEDTEWKLQKYSCNGQRYRSPRKKCQNL**AW LSSIQGCKFN*KNILYEKG*N*TS*NG*VKSSN E**KSSTRRSFISNYNGTSIWLRK*RRCCFSCCT L*RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE *PRAANS*TFLPFAFKEKIP*LLPAN*NAHITT TDPNKTEESRI*NFRSFGV*SEFNV*KCQTL*CA QFSHLQASSKIAASYAGKEERACQERRYRGRRQ HDLFSHL*YW*CQKKK*KEHKKAANENLIQCCS *SSRARFRQKTL*PIYG*TIQKGLS*LL*NHLGA NGLENN*A*HPQ*QICW*RGNDRRHEADVPECQ AL**GGLPGL**CTYPGEVTQGEKERAGPTA** **HGFSQTQAE*EEWHFS*KIKIHDSNAAETK*G L*SCKELY**EGSPPQCHISEASL*I*VA*LLS DY*KAHGHGKNSKSHDGQQVPRY*LYG*GLCHD V**CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGG R*GLSCPKCDFADSRAYPQSFCVSHESSG**GK MLQRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K *SLPSA*FISRAYV*SIGTSKKDESDRFRNI*RC SRTSAVFY*NS**TLQKWRDSSFTGTQLYHKTF A**CGEREKGKIAKRNRGR*TKTRRRKKRS*KE *RFLWCCRPLRLTSHIQPGL*L*KQHVPCWRLRL CGTCRGQPTTTYRLY*KTVGGFSW*KMVVWLLV LPTK*NIPPGYTKISRKRSF*E*LLQQSSS**N SRQVCGHVCQGIL*VMPRKLPR*GCFCL*ITVFC QNQIF*EN*TVDHAHQLSQVCPSGCASACGSRG LCICKCR*R***EEYRQLRGQSS*RQF*LGKGK RRCPCGNVQW*TRLPLL*AAPLQ*HVAEGWRLCL HQVPWPGASSCGQN*KSMGSRWSCIFLWPHLHS PRRNRA*AHKNVLQKRSISE*SGRNLPHDMYSR KVCCVVIQGLPLLQAN*NTRK*HSAL*EPLQ*ER QADEEIQRIEEVFTLC*SGR**NLLLQKTNCSS EGAITFAGKEDPVARS*ICRVRRWR**Y*RDGR RR**GH*TSFSTSASDPPGQ*AGPHALHTPTVYP KVCQRQCKEGRLQTENQHEWLHPVQQ*DEGCD* GPTPRLLFRGAQPPGGDRMEKS*DSQESRI*RH DGWLSARPSTFAGPS*WPC*HGQHAATSPWGAST PPSSARCAWPPGHPTTGCDEPRSGPYGRDSSTR WKSIWTTGGSFGASRAAGTTSISRPTSSWTPCH TAANNTHVCSSPTKDPAASSLRGLPEIH*RTQCG VQQH*QVGSDTGSSKTRRPFVERTGEPPTLSLA EKQRGPHHHGRCPLAPSRFDAPGHPQHSPSIQP RKCLITSLRFFYIEA*RVVDQ*PF*LLGVGGRNK GG*FLLHFTVHHKAIFIYGHF**AISICLLY*V DFIKYTKIFLHMFPSFKTSFIIGCICRLGVLSF YLLPWN*NH*RFLSWLGVFVFLVLGFFIYIYKRT K*KKTHTHKSLQISLN***NVKFVLVYILERGV YLCLFHVPEYLKPLSAKAVSYR*SAFFERWLFR F*MFNRHSTFALLTQRLTTEICNQCCASVCS*CT SWTPGGEKALFQLC*VRHL*VRLWCQ*FLQNTC TTLRYV*SRQVRLRIF*SIYNEFTIYAYKFQMI *NFKPVTLKNIEVRLEESIKVCMEVIYF*T*HLT *HG*ESMELDMSCIRSIIVNK*IDCLHIQVCFS IPYFLIIRCIFSFKFQCCYNSQPEI*YFLKYFL NLACAFELQEKGIII**NAY*KDHYRSQTLGFGD PVFLI*PYNKHLKAA*DGRQ*EHCFTWRHVFET CFIVTG*LPLW*SFHCCL*SERVNLRGCFFPFN LL*ISTQMFNYCTY*IMRAKECRMEKSLLYLDTL NMGGPLT*LPLVNHWI*ICIKYFK*Y*I*KNVL Q*CVSTLLLK*VR*IFNSWLFGQLNHHGLYNAI RLFCF*TSLNYTKEHEI*LWLNYLFISCIHFISL KVWMRLLWGASKKIFHWGPRGSLEARALLQAPS QCLEVL*ET*IQPGASLKQCSTGPGHH*TGPN* VFFKKPVYLF*NHVFLYINLGDIVNI*DIRFEVS HLQKRKKN*LKKVQVNYTPFFHKF*EL**CGLE SIMA*MFSKCKFLWRRIVYIANGGTEGNL*V*N SMFVSQLI*KAFNCFGCCFFFKPLSPSYEEELRG APISVKSPNWC**F*A*MFSYLIKTWFILISVS YHLRFTW*LVL*HVCIFFLLFI*SFLIQINTEF AK*

Sequence NM_018313

AGGAGCAATAGCAGCAGCCGTGGCGGCCACGGGGCGGGGCGCGGCGGTCGGTGACCGCGGCCGGGGCTGCAGGCGGCGGAGCGGCTGGAAGTTGGATTCC ATGGGTTCCAAGAGAAGAAGAGCTACCTCCCCTTCCAGCAGTGTCAGCGGGGACTTTGATGATGGGCACCATTCTGTGTCAACACCAGGCCCAAGCAGGA AAAGGAGGAGACTTTCCAATCTTCCAACTGTAGATCCTATTGCCGTGTGCCATGAACTCTATAATACCATCCGAGACTATAAGGATGAACAGGGCAGACT TCTCTGTGAGCTCTTCATTAGGGCACCAAAGCGAAGAAATCAACCAGACTATTATGAAGTGGTTTCTCAGCCCATTGACTTGATGAAAATCCAACAGAAA CTAAAAATGGAAGAGTATGATGATGTTAATTTGCTGACTGCTGACTTCCAGCTTCTTTTTAACAATGCAAAGTCCTATTATAAGCCAGATTCTCCTGAAT ATAAAGCCGCTTGCAAACTCTGGGATTTGTACCTTCGAACAAGAAATGAGTTTGTTCAGAAAGGAGAAGCAGATGACGAAGATGATGATGAAGATGGGCA AGACAATCAGGGCACAGTGACTGAAGGATCTTCTCCAGCTTACTTGAAGGAGATCCTGGAGCAGCTTCTTGAAGCCATAGTTGTAGCTACAAATCCATCA GGACGTCTCATTAGCGAACTTTTTCAGAAACTGCCTTCTAAAGTGCAATATCCAGATTATTATGCAATAATTAAGGAGCCTATAGATCTCAAGACCATTG CCCAGAGGATACAGAATGGAAGCTACAAAAGTATTCATGCAATGGCCAAAGATATAGATCTCCTCGCAAAAAATGCCAAAACTTATAATGAGCCTGGCTC TCAAGTATTCAAGGATGCAAATTCAATTAAAAAAATATTTTATATGAAAAAGGCTGAAATTGAACATCATGAAATGGCTAAGTCAAGTCTTCGAATGAGG ACTCCATCCAACTTGGCTGCAGCCAGACTGACAGGTCCTTCACACAGTAAAGGCAGCCTTGGTGAAGAGAGAAATCCCACTAGCAAGTATTACCGTAATA AAAGAGCAGTACAAGGAGGTCGTTTATCAGCAATTACAATGGCACTTCAATATGGCTCAGAAAGTGAAGAAGATGCTGCTTTAGCTGCTGCACGCTATGA AGAGGGAGAGTCAGAAGCAGAAAGCATCACTTCCTTTATGGATGTTTCAAATCCTTTTTATCAGCTTTATGACACAGTTAGGAGTTGTCGGAATAACCAA GGGCAGCTAATAGCTGAACCTTTTTACCATTTGCCTTCAAAGAAAAAATACCCTGATTATTACCAGCAAATTAAAATGCCCATATCACTACAACAGATCC GAACAAAACTGAAGAATCAAGAATATGAAACTTTAGATCATTTGGAGTGTGATCTGAATTTAATGTTTGAAAATGCCAAACGCTATAATGTGCCCAATTC AGCCATCTACAAGCGAGTTCTAAAATTGCAGCAAGTTATGCAGGCAAAGAAGAAAGAGCTTGCCAGGAGAGACGATATCGAGGACGGAGACAGCATGATC TCTTCAGCCACCTCTGATACTGGTAGTGCCAAAAGAAAAAGTAAAAAGAACATAAGAAAGCAGCGAATGAAAATCTTATTCAATGTTGTTCTTGAAGCTC GAGAGCCAGGTTCAGGCAGAAGACTTTGTGACCTATTTATGGTTAAACCATCCAAAAAGGACTATCCTGATTATTATAAAATCATCTTGGAGCCAATGGA CTTGAAAATAATTGAGCATAACATCCGCAATGACAAATATGCTGGTGAAGAGGGAATGATAGAAGACATGAAGCTGATGTTCCGGAATGCCAGGCACTAT AATGAGGAGGGCTCCCAGGTTTATAATGATGCACATATCCTGGAGAAGTTACTCAAGGAGAAAAGGAAAGAGCTGGGCCCACTGCCTGATGATGATGACA TGGCTTCTCCCAAACTCAAGCTGAGTAGGAAGAGTGGCATTTCTCCTAAAAAATCAAAATACATGACTCCAATGCAGCAGAAACTAAATGAGGTCTATGA AGCTGTAAAGAACTATACTGATAAGAGGGGTCGCCGCCTCAGTGCCATATTTCTGAGGCTTCCCTCTAGATCTGAGTTGCCTGACTACTATCTGACTATT AAAAAGCCCATGGACATGGAAAAAATTCGAAGTCACATGATGGCCAACAAGTACCAAGATATTGACTCTATGGTTGAGGACTTTGTCATGATGTTTAATA ATGCCTGTACATACAATGAGCCGGAGTCTTTGATCTACAAAGATGCTCTTGTTCTACACAAAGTCCTGCTTGAAACACGCAGAGACCTGGAGGGAGATGA GGACTCTCATGTCCCAAATGTGACTTTGCTGATTCAAGAGCTTATCCACAATCTTTTTGTGTCAGTCATGAGTCATCAGGATGATGAGGGAAGATGCTAC AGCGATTCTTTAGCAGAAATTCCTGCTGTGGATCCCAACTTTCCTAACAAACCACCCCTTACATTTGACATAATTAGGAAGAATGTTGAAAATAATCGCT ACCGTCGGCTTGATTTATTTCAAGAGCATATGTTTGAAGTATTGGAACGAGCAAGAAGGATGAATCGGACAGATTCAGAAATATATGAAGATGCAGTAGA ACTTCAGCAGTTTTTTATTAAAATTCGTGATGAACTCTGCAAAAATGGAGAGATTCTTCTTTCACCGGCACTCAGCTATACCACAAAACATTTGCATAAT GATGTGGAGAAAGAGAGAAAGGAAAAATTGCCAAAAGAAATAGAGGAAGATAAACTAAAACGAGAAGAAGAAAAAAGAGAAGCTGAAAAGAGTGAAGATT CCTCTGGTGCTGCAGGCCTCTCAGGCTTACATCGCACATACAGCCAGGACTGTAGCTTTAAAAACAGCATGTACCATGTTGGAGATTACGTCTATGTGGA ACCTGCAGAGGCCAACCTACAACCACATATCGTCTGTATTGAAAGACTGTGGGAGGATTCAGCTGAAAAAGAAGTTTTTAAGAGTGACTATTACAACAAA GTTCCAGTTAGTAAAATTCTAGGCAAGTGTGTGGTCATGTTTGTCAAGGAATACTTTAAGTTATGCCCAGAAAACTTCCGAGATGAGGATGTTTTTGTCT GTGAATCACGGTATTCTGCCAAAACCAAATCTTTTAAGAAAATTAAACTGTGGACCATGCCCATCAGCTCAGTCAGGTTTGTCCCTCGGGATGTGCCTCT GCCTGTGGTTCGCGTGGCCTCTGTATTTGCAAATGCAGATAAAGGTGATGATGAGAAGAATACAGACAACTCAGAGGACAGTCGAGCTGAAGACAATTTT AACTTGGAAAAGGAAAAAGAAGATGTCCCTGTGGAAATGTCCAATGGTGAACCAGGTTGCCACTACTTTGAGCAGCTCCATTACAATGACATGTGGCTGA AGGTTGGCGACTGTGTCTTCATCAAGTCCCATGGCCTGGTGCGTCCTCGTGTGGGCAGAATTGAAAAAGTATGGGTTCGAGATGGAGCTGCATATTTTTA TGGCCCCATCTTCATTCACCCAGAAGAAACAGAGCATGAGCCCACAAAAATGTTCTACAAAAAAGAAGTATTTCTGAGTAATCTGGAAGAAACCTGCCCC ATGACATGTATTCTCGGAAAGTGTGCTGTGTTGTCATTCAAGGACTTCCTCTCCTGCAGGCCAACTGAAATACCAGAAAATGACATTCTGCTTTGTGAGA GCCGCTACAATGAGAGCGACAAGCAGATGAAGAAATTCAAAGGATTGAAGAGGTTTTCACTCTCTGCTAAAGTGGTAGATGATGAAATTTACTACTTCAG AAAACCAATTGTTCCTCAGAAGGAGCCATCACCTTTGCTGGAAAAGAAGATCCAGTTGCTAGAAGCTAAATTTGCCGAGTTAGAAGGTGGAGATGATGAT ATTGAAGAGATGGGAGAAGAAGATAGTGAGTCTACCCCAAAGTCTGCCAAAGGCAGTGCAAAGAAGGAAGGCTCCAAACGGAAAATCAACATGAGTGGCT ACATCCTGTTCAGCAGTGAGATGAGGGCTGTGATTAAGGCCCAACACCCAGACTACTCTTTCGGGGAGCTCAGCCGCCTGGTGGGGACAGAATGGAGAAA TCTTGAGACAGCCAAGAAAGCAGAATATGAAGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATG GGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACC AAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCC ATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCA GAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGT CGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCT CCGGGACACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGT AGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTT TTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACCAGTTTCATA ATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCT TGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGT GAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTAC AGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATAT GTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGT TAGACTATGGTGTCAGTGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAAT GAATTCACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTAT GCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAA GTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGTTATAATTCT CAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATTTAATAAAACGCTTACTAGA AAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTA GGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAG AGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGT GTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAA GTATTTTAAATAATATTGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTT GGGCAATTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAA ATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGG GTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAGCAGTGCAGC ACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTTCTGTATATTAACTTGGGGG ATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTT TCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCA AACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTA AGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATA CCTGATTAAAACTTGGTTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTC ATCTAAAGCTTTTTAATCCAAATAAATACAGAGTTTGCAAAGTGA

refseq_PB1.F3 (forward primer)
refseq_PB1.R3 (reverse primer)
Single exon skipping

Frame 0

RSNSSSRGGHGAGRGGR*PRPGLQAAERLEVGF HGFQEKKSYLPFQQCQRGL**WAPFCVNTRPKQE KEETFQSSNCRSYCRVP*TL*YHPRL*G*TGQT SL*ALH*GTKAKKSTRLL*SGFSAH*LDENPTE TKNGRV**C*FADC*LPASF*QCKVLL*ARFS*I *SRLQTLGFVPSNKK*VCSERRSR*RR***RWA RQSGHSD*RIFSSLLEGDPGAAS*SHSCSYKSI RTSH*RTFSETAF*SAISRLLCNN*GAYRSQDHC PEDTEWKLQKYSCNGQRYRSPRKKCQNL**AWL SSIQGCKFN*KNILYEKG*N*TS*NG*VKSSNE DSIQLGCSQTDRSFTQ*RQPW*REKSH*QVLP** KSSTRRSFISNYNGTSIWLRK*RRCCFSCCTL* RGRVRSRKHHFLYGCFKSFLSAL*HS*ELSE*P RAANS*TFLPFAFKEKIP*LLPAN*NAHITTTDP NKTEESRI*NFRSFGV*SEFNV*KCQTL*CAQF SHLQASSKIAASYAGKEERACQERRYRGRRQHD LFSHL*YW*CQKKK*KEHKKAANENLIQCCS*SS RARFRQKTL*PIYG*TIQKGLS*LL*NHLGANG LENN*A*HPQ*QICW*RGNDRRHEADVPECQAL **GGLPGL**CTYPGEVTQGEKERAGPTA****H GFSQTQAE*EEWHFS*KIKIHDSNAAETK*GL* SCKELY**EGSPPQCHISEASL*I*VA*LLSDY *KAHGHGKNSKSHDGQQVPRY*LYG*GLCHDV** CLYIQ*AGVFDLQRCSCSTQSPA*NTQRPGGR* GLSCPKCDFADSRAYPQSFCVSHESSG**GKML QRFFSRNSCCGSQLS*QTTPYI*HN*EEC*K*SL PSA*FISRAYV*SIGTSKKDESDRFRNI*RCSR TSAVFY*NS**TLQKWRDSSFTGTQLYHKTFA* *CGEREKGKIAKRNRGR*TKTRRRKKRS*KE*RF LWCCRPLRLTSHIQPGL*L*KQHVPCWRLRLCG TCRGQPTTTYRLY*KTVGGFS*KRSF*E*LLQQ SSS**NSRQVCGHVCQGIL*VMPRKLPR*GCFCL *ITVFCQNQIF*EN*TVDHAHQLSQVCPSGCAS ACGSRGLCICKCR*R***EEYRQLRGQSS*RQF *LGKGKRRCPCGNVQW*TRLPLL*AAPLQ*HVAE GWRLCLHQVPWPGASSCGQN*KSMGSRWSCIFL WPHLHSPRRNRA*AHKNVLQKRSISE*SGRNLP HDMYSRKVCCVVIQGLPLLQAN*NTRK*HSAL*E PLQ*ERQADEEIQRIEEVFTLC*SGR**NLLLQ KTNCSSEGAITFAGKEDPVARS*ICRVRRWR** Y*RDGRRR**VYPKVCQRQCKEGRLQTENQHEWL HPVQQ*DEGCD*GPTPRLLFRGAQPPGGDRMEK S*DSQESRI*RHDGWLSARPSTFAGPS*WPC*H GQHAATSPWGASTPPSSARCAWPPGHPTTGCDEP RSGPYGRDSSTRWKSIWTTGGSFGASRAAGTTS ISRPTSSWTPCHTAANNTHVCSSPTKDPAASSL RGLPEIH*RTQCGVQQH*QVGSDTGSSKTRRPFV ERTGEPPTLSLAEKQRGPHHHGRCPLAPSRFDA PGHPQHSPSIQPRKCLITSLRFFYIEA*RVVDQ *PF*LLGVGGRNKGG*FLLHFTVHHKAIFIYGHF **AISICLLY*VDFIKYTKIFLHMFPSFKTSFI IGCICRLGVLSFYLLPWN*NH*RFLSWLGVFVF LVLGFFIYIYKRTK*KKTHTHKSLQISLN***NV KFVLVYILERGVYLCLFHVPEYLKPLSAKAVSY R*SAFFERWLFRF*MFNRHSTFALLTQRLTTEI CNQCCASVCS*CTSWTPGGEKALFQLC*VRHL*V RLWCQ*FLQNTCTTLRYV*SRQVRLRIF*SIYN EFTIYAYKFQMI*NFKPVTLKNIEVRLEESIKV CMEVIYF*T*HLT*HG*ESMELDMSCIRSIIVNK *IDCLHIQVCFSIPYFLIIRCIFSFKFQCCYNS QPEI*YFLKYFLNLACAFELQEKGIII**NAY* KDHYRSQTLGFGDPVFLI*PYNKHLKAA*DGRQ* EHCFTWRHVFETCFIVTG*LPLW*SFHCCL*SE RVNLRGCFFPFNLL*ISTQMFNYCTY*IMRAKE CRMEKSLLYLDTLNMGGPLT*LPLVNHWI*ICIK YFK*Y*I*KNVLQ*CVSTLLLK*VR*IFNSWLF GQLNHHGLYNAIRLFCF*TSLNYTKEHEI*LWL NYLFISCIHFISLKVWMRLLWGASKKIFHWGPRG SLEARALLQAPSQCLEVL*ET*IQPGASLKQCS TGPGHH*TGPN*VFFKKPVYLF*NHVFLYINLG DIVNI*DIRFEVSHLQKRKKN*LKKVQVNYTPFF HKF*EL**CGLESIMA*MFSKCKFLWRRIVYIA NGGTEGNL*V*NSMFVSQLI*KAFNCFGCCFFF KPLSPSYEEELRGAPISVKSPNWC**F*A*MFSY LIKTWFILISVSYHLRFTW*LVL*HVCIFFLLF I*SFLIQINTEFAK*

Frame 1

GAIAAAVAATGRGAAVGDRGRGCRRRSGWKLDS MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSR KRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRL LCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQK LKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPE YKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQ DNQGTVTEGSSPAYLKEILEQLLEAIVVATNPS GRLISELFQKLPSKVQYPDYYAIIKEPIDLKTI AQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGS QVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMR TPSNLAAARLTGPSHSKGSLGEERNPTSKYYRN KRAVQGGRLSAITMALQYGSESEEDAALAAARYE EGESEAESITSFMDVSNPFYQLYDTVRSCRNNQ GQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQI RTKLKNQEYETLDHLECDLNLMFENAKRYNVPNS AIYKRVLKLQQVMQAKKKELARRDDIEDGDSMI SSATSDTGSAKRKSKKNIRKQRMKILFNVVLEA REPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMD LKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHY NEEGSQVYNDAHILEKLLKEKRKELGPLPDDDD MASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYE AVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTI KKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFN NACTYNEPESLIYKDALVLHKVLLETRRDLEGDE DSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCY SDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNR YRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVE LQQFFIKIRDELCKNGEILLSPALSYTTKHLHN DVEKERKEKLPKEIEEDKLKREEEKREAEKSED SSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVE PAEANLQPHIVCIERLWEDSAEKEVFKSDYYNK VPVSKILGKCVVMFVKEYFKLCPENFRDEDVFV CESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPL PVVRVASVFANADKGDDEKNTDNSEDSRAEDNF NLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWL KVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFY GPIFIHPEETEHEPTKMFYKKEVFLSNLEETCP MTCILGKCAVLSFKDFLSCRPTEIPENDILLCE SRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDD IEEMGEEDSESTPKSAKGSAKKEGSKRKINMSG YILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRN LETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSM GSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMN QGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPP YPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHS EAYLKYIEGLSAESNSISKWDQTLAARRRDVHL SKEQESRLPSHWLKSKGAHTTMADALWRLRDLML RDTLNIRQAYNLENV*SHHYVSFI*KHKELWIS SHFSYWGWGEGTKEDNFYCILLYITRPFLYTDT FNKLFQFVCYIKLTLSNTQRFFCICFLRLKPVS* LVVYVDLEFYLFTCCHGTETIRGFCLGLGFLFS WFWVFLYIYIKEQNEKKHTHTRVYRLV*IDNEM *SLS*FTS*RGEYTCVCFMCLNILSHFLQKLFLT DEVLSLKGGYLGFRCLIDTAHLLY*LRGSLQKY VISAVHLSAANVPPGHQEGKKHFFNCAELDICE LDYGVSDFCRTRAQP*GMFNLGRYV*GYFDLFIM NSQFMPINFR*FKILNLLH*KTLKFVLKKALRY AWR*FIFKHNT*PNMGKRVWN*I*AV*EA*L*T SRLIAFIYKYVLVFLISLLSDVFFLLSFNVVIIL NQKFNTF*NIF*I*LVLLNYRRRES*FNKTLTR KTITDPKHLGLVTLSFLYDPTINI*RQHRMADS RNIVSLGGMFLKPAL**LGDCHCGRASTAVYNLR ELISEDAFFLLICYESVPRCLITVLIKS*GQKS VEWKKVSCI*IL*IWEAL*LNCL*STTGFEFAS SILNNIEFKKMYCSSVSVPYC*SESDKSSIPGYL GN*IIMDCIMQSDYFVSRHP*ITPKNMKFSCG* IIYLFHAFILFPLRSG*DFFGEPLKKFFTGGHV GH*KPELSSRLLPSA*RCYRKHRSSQGLP*SSAA PAQGITRQALIKFFLKSLCIYFRIMFFCILTWG ISLIFRI*DLRSAIFKKEKKIDSRKYK*TIHLF FISFRNCSNVA*KV*WPKCFQNVSSCGEELFILQ TGGLRGTCRFKTVCLSAN*FKRPLTVLVVVFFL SHSPLPMRKN*EGHLFL*NPQIGVDDFELECFH T*LKLGLF*FLYHII*GLRGN*SYNMYVSFFCCS SKAF*SK*IQSLQS

Frame 2

EQ*QQPWRPRGGARRSVTAAGAAGGGAAGSWIP WVPREEELPPLPAVSAGTLMMGTILCQHQAQAG KGGDFPIFQL*ILLPCAMNSIIPSETIRMNRAD FSVSSSLGHQSEEINQTIMKWFLSPLT**KSNRN *KWKSMMMLIC*LLTSSFFLTMQSPIISQILLN IKPLANSGICTFEQEMSLFRKEKQMTKMMMKMG KTIRAQ*LKDLLQLT*RRSWSSFLKP*L*LQIHQ DVSLANFFRNCLLKCNIQIIMQ*LRSL*ISRPL PRGYRMEATKVFMQWPKI*ISSQKMPKLIMSLA LKYSRMQIQLKKYFI*KRLKLNIMKWLSQVFE*G LHPTWLQPD*QVLHTVKAALVKREIPLASITVI KEQYKEVVYQQLQWHFNMAQKVKKMLL*LLHAM KRESQKQKASLPLWMFQILFISFMTQLGVVGITK GS**LNLFTICLQRKNTLIITSKLKCPYHYNRS EQN*RIKNMKL*IIWSVI*I*CLKMPNAIMCPI QPSTSEF*NCSKLCRQRRKSLPGETISRTETA*S LQPPLILVVPKEKVKRT*ESSE*KSYSMLFLKL ESQVQAEDFVTYLWLNHPKRTILIIIKSSWSQW T*K*LSITSAMTNMLVKRE**KT*S*CSGMPGTI MRRAPRFIMMHISWRSYSRRKGKSWAHCLMMMT WLLPNSS*VGRVAFLLKNQNT*LQCSRN*MRSM KL*RTILIRGVAASVPYF*GFPLDLSCLTTI*LL KSPWTWKKFEVT*WPTSTKILTLWLRTLS*CLI MPVHTMSRSL*STKMLLFYTKSCLKHAETWREM RTLMSQM*LC*FKSLSTIFLCQS*VIRMMREDAT AIL*QKFLLWIPTFLTNHPLHLT*LGRMLKIIA TVGLIYFKSICLKYWNEQEG*IGQIQKYMKMQ* NFSSFLLKFVMNSAKMERFFFHRHSAIPQNICIM MWRKRERKNCQKK*RKIN*NEKKKKEKLKRVKI PLVLQASQAYIAHTARTVALKTACTMLEITSMW NLQRPTYNHISSVLKDCGRIQLKKKFLRVTITTK FQLVKF*ASVWSCLSRNTLSYAQKTSEMRMFLS VNHGILPKPNLLRKLNCGPCPSAQSGLSLGMCL CLWFAWPLYLQMQIKVMMRRIQTTQRTVELKTIL TWKRKKKMSLWKCPMVNQVATTLSSSITMTCG* RLATVSSSSPMAWCVLVWAELKKYGFEMELHIF MAPSSFTQKKQSMSPQKCSTKKKYF*VIWKKPAP *HVFSESVLCCHSRTSSPAGQLKYQKMTFCFVR AATMRATSR*RNSKD*RGFHSLLKW*MMKFTTS ENQLFLRRSHHLCWKRRSSC*KLNLPS*KVEMMI LKRWEKKIVSLPQSLPKAVQRRKAPNGKST*VA TSCSAVR*GL*LRPNTQTTLSGSSAAWWGQNGE ILRQPRKQNMKA*WVAIRQAFHLCRAQLMALLAW AACSHFTLGGLHPTIFRQVCLASRASHHRV**T KEWPLW*GLQHQVEVHMDNRWEFWGLQGSRHHL HIPAHIQLDPLSYSSQQHPCL*LPHQRPSGFFTQ RPT*NTLKDSVRSPTALASGIRHWQLEDATSIC RKNRRAAYPLTG*KAKGPTPPWQMPSGAFEI*C SGTPSTFAKHTT*KMFNHIITFLLYRSIKSCGSV AILVTGGGGKEQRRIIFIAFYCTSQGHFYIRTL LISYFNLFVILS*LYQIHKDFFAYVSFV*NQFH NWLYM*TWSFIFLLVAMELKPLEVFVLAWGFCFL GFGFFYIYI*KNKMKKNTHTQEFTD*FKLIMKC EVCPSLHLREGSILVFVSCA*IS*ATFCKSCFL QMKCFL*KVVI*VLDV**TQHICSINSEAHYRNM *SVLCICLQLMYLLDTRRGKSTFSIVLS*TSVS *TMVSVIFAEHVHNPEVCLI*AGTFKDILIYL* *IHNLCL*ISDDLKF*TCYIEKH*SSS*RKH*GM HGGDLFLNITPNLTWVREYGTRYELYKKHNCEQ VD*LPSYTSMF*YSLFPYYQMYFFF*VSMLL*F STRNLILSKIFFKFSLCF*ITGEGNHNLIKRLLE RPLQIPNTWVW*PCLSYMTLQ*TFEGSIGWQTV GTLFHLAACF*NLLYSNWVIAIVVELPLLFII* ES*SQRMLFSF*SAMNQYPDV*LLYLLNHEGKRV *NGKKSLVSRYFKYGRPFNLIAFSQPLDLNLHQ VF*IILNLKKCIAVVCQYLIVKVSQINLQFLAI WAIESSWTV*CNQIILFLDILELHQRT*NLVVVK LFIYFMHSFYFP*GLDETSLGSL*KNFSLGATW VIRSQSSPPGSFPVPRGAIGNIDPARGFPKAVQ HRPRASLDRP*LSFF*KACVFILESCFSVY*LGG YR*YLGYKI*GQPSSKKKKKLTQESTSKLYTFF S*VLGTVVMWLRKYNGLNVFKM*VPVEKNCLYC KRGD*GEPVGLKQYVCQPTDLKGL*LFWLLFFF* ATLPFL*GRIERGTYFCKIPKLVLMILSLNVFI PD*NLVYSNFCIISSEVYVVTSLITCMYLFFVV HLKLFNPNKYRVCKV