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Sequences

Sequence NM_213589

GCGGCCGCCCCGCCCCCGCTCCCGCCGCCGCCCGCCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCACTGAGCGCGCGGCGCGGGAGCTG CTGGCAGTCGCTGCGTCTCTGGCGAGGGAGCGCCGCGCCTGGGGAGGAGGCGGAGGCAGCGGCTGGAGGAGCGCGAGCGGCGGTTTCCTTGCCCGGGGCC GCGGGAAGGCCGACCGACTGCCGCGATGGAGCAGCTATCAGATGAAGAAATTGATCATGGTGCTGAAGAAGACAGTGACAAGGAAGATCAGGACCTGGAC AAAATGTTTGGAGCCTGGCTTGGAGAACTAGACAAACTCACTCAGAGTTTGGATTCTGACAAGCCCATGGAACCAGTAAAAAGATCTCCTCTTCGCCAGG AAACAAACATGGCCAACTTTTCTTACCGCTTCTCCATATACAACTTGAATGAAGCTCTGAATCAGGGAGAGACTGTGGATCTGGATGCCTTGATGGCTGA TCTTTGCTCTATAGAGCAGGAGCTCAGCAGCATTGGTTCAGGAAACAGTAAGCGTCAAATCACAGAAACGAAAGCTACTCAGAAATTGCCTGTTAGCCGA CATACATTGAAACATGGCACCTTGAAAGGATTATCTTCTTCATCTAATAGGATAGCTAAACCTTCCCATGCCAGCTACTCCTTGGACGACGTCACTGCAC AGTTAGAACAGGCCTCTTTGAGTATGGATGAGGCTGCTCAGCAATCTGTACTAGAAGATACTAAACCCTTAGTAACTAATCAGCACAGAAGAACCGCGTC AGCAGGCACAGTGAGTGATGCTGAAGTACACTCTATTAGTAATTCCTCCCATTCCAGCATCACTTCCGCAGCCTCCAGCATGGACTCTTTGGATATTGAT AAAGTAACACGCCCTCAAGAGCTGGATTTGACACATCAAGGGCAGCCAATTACTGAGGAAGAACAGGCAGCAAAATTGAAAGCTGAGAAGATCAGAGTTG CCCTAGAGAAAATTAAAGAGGCACAAGTGAAAAAGCTGGTGATCAGAGTCCACATGTCTGATGACAGTTCTAAAACAATGATGGTGGATGAGAGGCAGAC AGTAAGACAAGTACTGGATAACCTGATGGACAAATCCCACTGCGGTTATAGTTTAGACTGGTCACTGGTAGAAACCGTTTCTGAATTACAAATGGAGAGA ATCTTTGAAGACCATGAAAACTTGGTTGAAAATCTTCTTAATTGGACAAGAGATAGCCAAAACAAGCTTATATTTATGGAGCGTATAGAAAAATATGCAC TTTTCAAAAACCCACAGAATTATCTTTTGGGGAAAAAAGAAACAGCTGAGATGGCAGATAGAAACAAAGAAGTCCTCTTGGAGGAATGTTTTTGTGGAAG TTCTGTAACTGTACCAGAAATTGAAGGAGTCCTTTGGTTGAAGGATGATGGCAAGAAGTCCTGGAAAAAGCGTTATTTTCTCTTGCGAGCATCTGGTATC TACTATGTTCCCAAAGGAAAAGCAAAGGTCTCTCGGGATCTGGTGTGCTTTCTCCAGCTGGATCATGTCAACGTTTATTATGGCCAGGACTATCGGAACA AATACAAAGCACCTACAGACTATTGTCTGGTGCTGAAGCATCCACAAATCCAGAAGAAATCTCAATATATCAAATACCTTTGTTGTGATGATGTGAGGAC ACTGCATCAGTGGGTCAATGGGATCCGCATTGCAAAGTATGGGAAGCAGCTCTATATGAACTACCAAGAAGCCTTGAAGAGGACAGAGTCAGCCTATGAT TGGACTTCCTTATCCAGCTCCAGCATTAAATCGGGATCCAGTTCTTCCAGCATCCCAGAGTCTCAGTCAAACCACTCCAATCAGTCTGATAGCGGAGTTT CTGACACCCAGCCAGCAGGACACGTCCGTTCCCAGAGCATTGTGAGCTCCGTATTCTCTGAAGCCTGGAAACGAGGCACTCAGTTGGAAGAGTCCAGCAA GGCCAGAATGGAGTCTATGAATCGGCCCTACACTTCACTTGTGCCCCCTTTATCCCCGCAACCTAAGATAGTCACCCCCTACACTGCTTCACAGCCTTCA CCACCTCTACCTCCTCCGCCACCCCCACCTCCTCCTCCACCACCCCCTCCACCACCCCCTCCTCCCCCACTCCCCAGCCAGTCTGCACCTTCTGCAGGCT CAGCAGCCCCAATGTTCGTCAAGTACAGCACAATAACACGGCTACAGAATGCGTCTCAGCATTCAGGGGCCCTGTTTAAGCCGCCAACACCCCCAGTGAT GCAGTCACAGTCAGTGAAGCCTCAGATCCTGGTACCCCCCAATGGAGTTGTTCCACCACCCCCTCCCCCTCCTCCACCCCCAACCCCAGGCTCTGCCATG GCCCAGCTAAAGCCTGCACCGTGTGCCCCATCCCTTCCACAGTTCAGTGCCCCGCCTCCTCCACTGAAGATCCATCAAGTTCAGCATATTACTCAGGTGG CTCCCCCAACACCCCCCCCACCTCCTCCTATCCCTGCACCCCTCCCTCCCCAAGCTCCCCCAAAACCCCTTGTGACCATCCCCGCACCAACCAGCACCAA GACTGTGGCACCTGTTGTGACTCAAGCTGCACCACCCACACCTACTCCTCCAGTGCCCCCAGCAAAAAAGCAGCCAGCTTTCCCTGCTTCTTACATTCCA CCCTCTCCCCCTACCCCTCCTGTTCCAGTACCCCCGCCAACATTACCCAAGCAACAGAGCTTCTGTGCAAAACCCCCTCCCTCTCCACTGTCACCGGTGC CCTCGGTCGTGAAGCAGATAGCCAGCCAGTTTCCACCCCCTCCAACTCCCCCTGCCATGGAATCTCAGCCCTTAAAGCCTGTCCCAGCAAATGTAGCTCC ACAGTCCCCTCCTGCAGTAAAAGCAAAGCCCAAGTGGCAGCCCAGCTCCATCCCAGTCCCTTCTCCGGACTTCCCTCCTCCCCCTCCTGAAAGCAGCCTG GTGTTTCCTCCTCCACCCCCATCACCTGTCCCAGCCCCACCACCACCACCTCCACCCACAGCTTCTCCTACCCCTGACAAAAGTGGATCTCCAGGCAAAA AGACCAGTAAGACGTCCAGCCCTGGGGGAAAGAAACCACCCCCAACCCCACAGCGCAACTCCAGCATTAAATCCAGCAGTGGTGCAGAGCACCCCGAGCC CAAGAGACCCTCGGTGGACAGTCTAGTCAGCAAGTTTACACCGCCAGCAGAATCAGGGTCTCCCAGCAAGGAGACCCTACCACCTCCTGCAGCACCCCCC AAGCCTGGAAAACTCAATCTTTCTGGAGTCAACCTTCCTGGAGTTCTCCAACAAGGGTGTGTGTCAGCAAAAGCCCCTGTTCTGAGTGGGCGTGGAAAGG ACTCCGTGGTGGAATTTCCTTCTCCTCCATCCGATTCTGATTTTCCACCCCCTCCACCTGAAACAGAGCTTCCTCTGCCCCCCATTGAGATTCCAGCAGT TTTCTCGGGAAACACCTCTCCAAAAGTGGCAGTCGTTAATCCTCAACCACAACAATGGTCTAAAATGTCAGTGAAGAAGGCCCCTCCACCCACACGACCC AAACGGAATGATAGCACCCGCCTCACTCAAGCTGAGATTTCTGAGCAGCCAACAATGGCCACAGTTGTGCCACAAGTGCCCACCTCTCCCAAATCCAGCC TTAGTGTCCAGCCTGGATTCCTGGCTGACCTCAACAGGACACTGCAACGAAAGTCCATCACTCGGCACGGCTCACTCTCCTCCCGCATGTCCAGAGCAGA ACCAACAGCCACCATGGATGATATGGCATTGCCTCCACCACCCCCTGAACTGCTGTCTGATCAACAGAAGGCTGGTTACGGAGGCAGTCATATATCAGGC TATGCAACGTTGCGGAGAGGACCCCCTCCTGCTCCCCCCAAAAGAGACCAGAACACCAAGCTCTCCAGAGACTGGTAGCCACCATAGGACTTTATTTTCA TGATATCTGTAATCACTGCTACAATCAGCTCACCTGATCATCTGTGAATTCAGGTGTTCAGAGCCTCCTGGTATGATGTTATTCAGGTAGTGTCCAGCTA TATGTGTATGTGTGTGTGTACACGTGCATGTACACACAGCTGTACAGTGTGTGTATATATGTATACATATATGTATGTGTATGTGTATATAGAGAGAGAG CTGAGAGTTATTCTATTTATTCCTTTTCTCTCCTAATCTGAAAATGGGTGTTCTGTATTTTGGGTGGAAGAGGCATAGAAGGGGATGTGTGTTGTCTCTT AAGATTTCTATATCATGTGGATTGGACCAAAAACTTCTAATCACTTATTTAGAAGGTATTTATAAGTGTCTGTCCATGTGTAGCCTATTCGTGCATGTTG TGTATTATATAACTAAGGAATAGATGTAGAATGTGCTATTTCTGGTTGAGAAAAATCACCAGAATGTTTGGTGTATCTATAAGGCTTTTGTGTTTGTTTT TCCCCAGTTGGCTGAAGTTAGAATTGCTTGACTGACACTTCATTGCTATACATGAAGGGGCACTTTAAATCAGGAAAATCTCTCAGCTTCATAGAACGGG TAACTAGTGCAGGATGGGGAAATGTTCACAGACATCATCTGTATGTGGTTGTGCATAGAAAGTAAATACATGGCGTAATTAACTCAGCTGTTCTAGCTGC AGTACTGCTGCAGTGATCCACCCACATTTAGGATGTGCTGACAGATAAGCTCTTTGCCTACAATACATGGATAATTAGTGCTATAATTCTGGATAGTTCC TTTTTAGTACTGTTTTATGAAGCTTTATCAACTTGGCTTCATGATCCTCACTTTGATTGATTTTAAGAGGATGGATAACACAGTTATCTCTGTAATGTTC TGTCCCAGTATGTCTTTGGGTCACCAGTTACCTTCTTAAAATATGTGCTTTAGGTAGGTGTTATTACATATCTGTAGACAATTGGTATATGAAATATACA CATCCTGTGCCCCAATATGGTGCATTATGAAAAACAAAATCATTTTCTAAAATGCATTTTTTGAGCATTGCTCTATAGAAGGGAAGGGTGATGAGAGAAC AGAACTGGCCCCTGTACAGGTGTCATTAATCTGGTTGTATATGGGTTATAATATGTAATACAAAAAGCTCATTAAGTATGGGACTACATGGAGAGGGAAG ACAGTTTCATTTATAGCTACTGGGGCTACCAGGACCCTTGCTGACTGCAGCCTGGTTGTGATTAGTTCAGGTTACTAGGTGTTCTGATGGAGTGGGACAG TCCAAGTCCAGTAACTGACATTACGTTTTATGCGTGTGCAGTTTGGTATAACGTGGAGTCAGTGCTCTAACGACACACTATACTTCTATATGCTTTTTTC TGTGAATTTTCCTTGGTACATGAGAGAAATAAGTACTCTCATCAACTTATGATAAATTGGACTATTAGGAATAAAACAATCTCAGAGCAGCTCCTAAACA AGAGAATAAAAATGGGCCATCCCAGCACTTATAAGGGGAGCACATCTTGTAATGAAAGTCTGTGCCTATTGTTAATGATTACCAATGCAAACTGCAGAAA TCAGTTGACATTGTCCCACAAGGAAAAAGTGATGCCAGTAAAGTGGGGGAAGAGATGGTAAATAATTCTAGAATGAGCAAAAGTGCTTAATTAGTACAGT ATACTCAAGGTCTTGCATAACCCACACTCCACGAAAACCGCATCGTAAACAGAGAGTGAACAGCACCTCTCCATTGCTACATCTCCAGAATATTGTTCGG TTATGTTCATGTGGTTATGGAGCAATAAGAATATATACCATTAATTTTTAGGTCTTTCAAATTGTTCACCAAGTTTTGTGTTTGATATTTATGAAGTGAT CTTTAACACATCTGCATTGTTAATTTAAGCATGCACAGAAATTTGGGTAATGTTTGAGTAGATTGCCAAGCGCTACTGTGATTCATGAATGAATTTCTCA TAGTCTTCTGCCTGCAGTTTTATAGTTTGAGGGGCACCCATATTTGTGGGTTAGAGTTAGTAAGAATATGAATCCAGTTATCAAAGTATTCATCCCTGAG GTTTTGAGTTTTATTGTGGTGGTGATTTTCTCATGAGAAGGTAGACAACACTTCAGTTTTTCTTGAGGGGGAAAAAATGTACCCGCTAACCTTTTTTCAC CCATGATTTGAGCCCTAAAACAACAGCCTTTATGTTTTCAGTGCAGGATTTCTTGGAATTTCTTGCTTGTATCAATCCTGATGATAGCCATCCTGAACAG ATGCTTCTGGTCTGTTTTCCTGGAATAGCAGACATCCTTTTGAACACTAATGATGCCAGGAAGAGAGTAAGGCTAGAGGAGGAGACTCATTTTAACCCCA GTCCAGTGGCTTGTCCGACAACAGGCCATTTCCCTTTACATTCCTCCACAGACAGAAATGGCTATTAAAAATGTTTTAACCTCATGTATGAACTGAATTT AAAAAACCACTAAAGTGATACTTTATACTTCTGTTTTACTCCCTAGTGGGTTTTCTTTAATTTGGATTTTTGTTGGGATGTAGCTTTTCCTAGACTGTAT TTCTGTAGCTCTTTTTCTCTGGTGTATTCATGGAAAGCATCTACTGCCGCACGACACTAGTACTGTGCCTTCTTTCACTGCCCTCTGCTCTGCAGCTCTC ACCCAGCTTGGCTGCTTCAAGTCTGTGCAGTTGACTTGGCTGTACTGAAAAGTGAACAGCATGGATTAACTCATCCTGCTGCTGAGGGCAGTGCAAACAG GTGCTTATTAGAGGTAGTGACTTGCTTAATTAGTGACACTCCTAATTTCTACTATGGATAATTTCAAAGTAGAATCACTCTATGCTTAGAGTTTTGGCAC CAATGCTGTAGGGCAGCAGAATCTATTCTCAGTAAAATAACTTATGGTTTATTAGATATTCTGTATTGGATTTTACCAGCTTGACTTTTACTGCTCAGAT GCTTTCTTTCCCCCCCTTAGACGCTGTAATTCTCTTGGGAAGAGTAACTATTCTTAAGGTTTTTACAGATACCCACCTTAGTTGTAAATTGGATAGTTTA TATTTCTGGGACTTTTTAAATGAAAATGTGGAATGTTAAGTTACAAAAGACTTTTCATCAGAAAATTTCAAACAAAGTAAACATGGCGTTTTATAGTCCT CTAAAATCTAGGTGCTCCCACCCACCAAAGGCATATCCTGCAAAGGGCTGTGAACTATCTTGGTGAACTGTCTTGGGTCCCCTTTCCATGTATGTTTTCT TGTCACTGAAAACAAACAACGCTGAGTTTATCAAGAAAATTTAAATTGGGGGATCATAATAATTCCAACCAAGTGACAACTCTGACATCAAGGTTATTAG GAGCTGTACATCCAATTCAAGTTTTATTTGCTGCTATTCTGGGAGAATAAACTTGTATATGGAGAATAAACTAATAAACTTGTATCGAGGAAATCCATAA AGTTATAAATTAGCCTGAAAAATATTTCAGGTAATGGTGTGGATTGGCCTGCTTTGACTCTCAGCCACCAACAGAAATCTTTGTCACCTTTGTTCCTCAG CTAAAAGTAATTTTGTTATAAACACAAAGTGACTTTAAACAGGTAAAAAACCCATTCCTATTTTTGTACATTACCAAAAGTTTTTCATATACCTACAGAG CTAACTAATTACAACTGATTTAATCCACTCAAGTTTAGACCAGTTAAACCCATAGGATCCTGTATGGTTATCAATGTGATGCCTTGCTTTTCATAAAATA GGTATAATTGGGTCATACACTTGACGAGAGGGTGACTGTTTCTAGGGGAAGAAAACCCTTTAGATTGCAGGTAACTTTCACTTTTTTTTTTTTAATATAC ACTTTACATTTGTATAAATTATGCAGGGTACTCCTAACCCTGTAGAAATGTATGACCTCTCACAAAGTTGAGATTTGATCCAAAGAGAAATGCAAGTATA AAAGAATTAGATACTTATTATCTTTTAAGGTTTTTTTTTTTTTTTGGTAGAGATGGGGGTCTCACTGTGTTGCCCAGGCTGGTCTCAAACTCCTGGCCAC AAGTGATCTTCCTGCCTCAGCCTCCCAAAATGCTGAGATTACAGGCATGAGCCACTGTACCCAGCCTTTCCTTATAAAATTCAAAGAGAAAATTTCTACA CCTTTATCCCTCAAATAAAACAAGTGCTCAGTTCTTACCGTGCCCTTGCAAGGTCTATATGTAAAAGAAATCTGAAATTTAGCTGTAGAATAAAACTTGA TAAATAAAAAGAAAAAACATACATTTCTCCAGTTGGTTTGCTCTTTGCTTGTTGAAGTAATAAACCGTTTTAAAGAGAAAATACTTGCTGTAAACCCCCA GTGCCTTCAACTCTTTTGGCAGAATATTTTTAAAGAAATCCAGCAAGCAAACTTTGAGGTGCTAATGAAAGTAAAGGAAGGTGGTATTTCTAGTTTTGGC AGAAATGAAAAGTGTCTCACAAGAGACATCACTACCCACGTGGGGTCTGGCTGCTTTCTACCAAAGACATTTAGAGAAGTGAATTGAGTCAGGGTGATGG TGAACACTACATATTTTATAGATGGTTAAGTTGAGAATTAATTATGTTTATCATGGATGGCTACTAATACCAAGCTCATGATTGTTGCAGCCTCAACGTC TTAGGCAGTAAAACTTGTCTGCAGCACTAAAGGGGGAGAAACCCTTATATTTTGCAAACTGTCCATTCGTTAAATTTATTGTAACCTAATACCAAAAACT GCCGTTTTTCATATTATTTCCCCACCTCCTACTTTTTTTTTTTTTTTTGCTACTTGTAAAATAACCCCTTCTAGAAAATAAGCATTAACTGGAATGTTTC AAACAATTTTGCTTCATTTTACTATCAGCCACTAGTGAACTCTTACAGAGATGTACATTTAAGATAAAATTAGCTTGTGCTAAGTGTTTTAAAAACATTG TTTACTGTTAAAGGGGAATTGCACATTATATTTAACTGGGATTGCTCCCTCCCTCAGTTCTTTAAAAAACAAGAGTCAAGGCTCACACCAACTTGTAGGC TGTGGGAGCTTTGCCATAGGTAGATACAATGTAGAAGTATACTTTTTTAAAGCATGAAGAAGACAAGGAACTTCATTATAATGTACCAGGTAGAGGACAT TATTATTCAAAGGATTATGCACAGCTCAGTGAAGATGAAGTTACAATTTTTCTCGCAGCTTTGTTGCTATTATTTTCTTCTGCATAAATGTATGCTCATT TCATTATGTGCCTTGCTCCCTGATTGTGCAAAGCTATATATATATATATATATATATAGATAGATAGATAGATATATGAGAGAGATATATTCAGTACTAC TGAGGATGTTTTTCTGAGGATGTTTTTGTTCTGCTGGATTAAGTTATTTTCCAAGTTACTCTTGCCAGTTATGTCAGTAAACTATTGTAATGGCTTAGCA CACTAGTCGTACAGTCAGTGTAAATGTTTTTCATTTACATGTTTTCATTATATCAGCTTATCAAATCCTTAATAAAAAAAATTCATAGATTTCATTTAAA

refseq_RAPH1.F1 (forward primer)
refseq_RAPH1.R1 (reverse primer)
Multiple exon skipping

Frame 0

AAAPPPLPPPPASQSVSQSVSQSVSH*ARGAGA AGSRCVSGEGAPRLGRRRRQRLEERERRFPCPGP REGRPTAAMEQLSDEEIDHGAEEDSDKEDQDLD KMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQ ETNMANFSYRFSIYNLNEALNQGETVDLDALMAD LCSIEQELSSIGSGNSKRQITETKATQKLPVSR HTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTA QLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTAS AGTVSDAEVHSISNSSHSSITSAASSMDSLDID KVTRPQELDLTHQGQPITEEEQAAKLKAEKIRV ALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQT VRQVLDNLMDKSHCGYSLDWSLVETVSELQMER IFEDHENLVENLLNWTRDSQNKLIFMERIEKYA LFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGI YYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRN KYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRT LHQWVNGIRIAKYGKQLYMNYQEALKRTESAYD WTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGV SDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK ARMESMNRPYTSLVPPLSPQPKIVTPYTASQPS PPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAG SAAPMFVKYSTITRLQNASQHSGALFKPPTPPVM QSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAM AQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQV APPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTK TVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIP PSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPV PSVVKQIASQFPPPPTPPAMESQPLKPVPANVAP QSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSL VFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEP KRPSVDSLVSKFTPPAESGSPSKETLPPPAAPP KPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGK DSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAV FSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRP KRNDSTRLTQAEISEQPTMATVVPQVPTSPKSS LSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAE PTATMDDMALPPPPPELLSDQQKAGYGGSHISG YATLRRGPPPAPPKRDQNTKLSRDW*PP*DFIF MISVITATISSPDHL*IQVFRASWYDVIQVVSSY MCMCVCTRACTHSCTVCVYMYTYMYVYVYIERE LRVILFIPFLS*SENGCSVFWVEEA*KGMCVVS *DFYIMWIGPKTSNHLFRRYL*VSVHV*PIRACC VLYN*GIDVECAISG*EKSPECLVYL*GFCVCF SPVG*S*NCLTDTSLLYMKGHFKSGKSLSFIER VTSAGWGNVHRHHLYVVVHRK*IHGVINSAVLAA VLLQ*STHI*DVLTDKLFAYNTWIISAIILDSS FLVLFYEALSTWLHDPHFD*F*EDG*HSYLCNV LSQYVFGSPVTFLKYVL*VGVITYL*TIGI*NIH ILCPNMVHYEKQNHFLKCIF*ALLYRREG**EN RTGPCTGVINLVVYGL*YVIQKAH*VWDYMERE DSFIYSYWGYQDPC*LQPGCD*FRLLGVLMEWDS PSPVTDITFYACAVWYNVESVL*RHTILLYAFF CEFSLVHERNKYSHQLMINWTIRNKTISEQLLN KRIKMGHPSTYKGSTSCNESLCLLLMITNANCRN QLTLSHKEKVMPVKWGKRW*IILE*AKVLN*YS ILKVLHNPHSTKTAS*TESEQHLSIATSPEYCS VMFMWLWSNKNIYH*FLGLSNCSPSFVFDIYEVI FNTSALLI*ACTEIWVMFE*IAKRYCDS*MNFS *SSACSFIV*GAPIFVG*S**EYESSYQSIHP* GFEFYCGGDFLMRR*TTLQFFLRGKKCTR*PFFT HDLSPKTTAFMFSVQDFLEFLACINPDDSHPEQ MLLVCFPGIADILLNTNDARKRVRLEEETHFNP SPVACPTTGHFPLHSSTDRNGY*KCFNLMYELNL KNH*SDTLYFCFTP*WVFFNLDFCWDVAFPRLY FCSSFSLVYSWKASTAARH*YCAFFHCPLLCSS HPAWLLQVCAVDLAVLKSEQHGLTHPAAEGSANR CLLEVVTCLISDTPNFYYG*FQSRITLCLEFWH QCCRAAESILSKITYGLLDILYWILPA*LLLLR CFLSPP*TL*FSWEE*LFLRFLQIPTLVVNWIVY ISGTF*MKMWNVKLQKTFHQKISNKVNMAFYSP LKSRCSHPPKAYPAKGCELSW*TVLGPLSMYVF LSLKTNNAEFIKKI*IGGS**FQPSDNSDIKVIR SCTSNSSFICCYSGRINLYMENKLINLYRGNP* SYKLA*KIFQVMVWIGLL*LSATNRNLCHLCSS AKSNFVINTK*L*TGKKPIPIFVHYQKFFIYLQS *LITTDLIHSSLDQLNP*DPVWLSM*CLAFHKI GIIGSYT*REGDCF*GKKTL*IAGNFHFFFFNI HFTFV*IMQGTPNPVEMYDLSQS*DLIQREMQV* KN*ILIIF*GFFFFLVEMGVSLCCPGWSQTPGH K*SSCLSLPKC*DYRHEPLYPAFPYKIQRENFY TFIPQIKQVLSSYRALARSICKRNLKFSCRIKLD K*KEKTYISPVGLLFAC*SNKPF*RENTCCKPP VPSTLLAEYF*RNPASKL*GANESKGRWYF*FW QK*KVSHKRHHYPRGVWLLSTKDI*RSELSQGDG EHYIFYRWLS*ELIMFIMDGY*YQAHDCCSLNV LGSKTCLQH*RGRNPYILQTVHSLNLL*PNTKN CRFSYYFPTSYFFFFFCYL*NNPF*KISINWNVS NNFASFYYQPLVNSYRDVHLR*N*LVLSVLKTL FTVKGELHIIFNWDCSLPQFFKKQESRLTPTCR LWELCHR*IQCRSILF*SMKKTRNFIIMYQVEDI IIQRIMHSSVKMKLQFFSQLCCYYFLLHKCMLI SLCALLPDCAKLYIYIYIYR*IDRYMREIYSVL LRMFF*GCFCSAGLSYFPSYSCQLCQ*TIVMA*H TSRTVSVNVFHLHVFIISAYQILNKKNS*ISFK

Frame 1

RPPRPRSRRRPPVSQSVSQSVSQSVTERAAREL LAVAASLARERRAWGGGGGSGWRSASGGFLARG RGKADRLPRWSSYQMKKLIMVLKKTVTRKIRTWT KCLEPGLEN*TNSLRVWILTSPWNQ*KDLLFAR KQTWPTFLTASPYTT*MKL*IRERLWIWMP*WL IFAL*SRSSAALVQETVSVKSQKRKLLRNCLLAD IH*NMAP*KDYLLHLIG*LNLPMPATPWTTSLH S*NRPL*VWMRLLSNLY*KILNP**LISTEEPR QQAQ*VMLKYTLLVIPPIPASLPQPPAWTLWILI K*HALKSWI*HIKGSQLLRKNRQQN*KLRRSEL P*RKLKRHK*KSW*SESTCLMTVLKQ*WWMRGR Q*DKYWIT*WTNPTAVIV*TGHW*KPFLNYKWRE SLKTMKTWLKIFLIGQEIAKTSLYLWSV*KNMH FSKTHRIIFWGKKKQLRWQIETKKSSWRNVFVE VL*LYQKLKESFG*RMMARSPGKSVIFSCEHLVS TMFPKEKQRSLGIWCAFSSWIMSTFIMARTIGT NTKHLQTIVWC*SIHKSRRNLNISNTFVVMM*G HCISGSMGSALQSMGSSSI*TTKKP*RGQSQPMI GLPYPAPALNRDPVLPASQSLSQTTPISLIAEF LTPSQQDTSVPRAL*APYSLKPGNEALSWKSPA RPEWSL*IGPTLHLCPLYPRNLR*SPPTLLHSLH HLYLLRHPHLLLHHPLHHPLLPHSPASLHLLQA QQPQCSSSTAQ*HGYRMRLSIQGPCLSRQHPQ* CSHSQ*SLRSWYPPMELFHHPLPLLHPQPQALPW PS*SLHRVPHPFHSSVPRLLH*RSIKFSILLRW LPQHPPHLLLSLHPSLPKLPQNPL*PSPHQPAP RLWHLL*LKLHHPHLLLQCPQQKSSQLSLLLTFH PLPLPLLFQYPRQHYPSNRASVQNPLPLHCHRC PRS*SR*PASFHPLQLPLPWNLSP*SLSQQM*L HSPLLQ*KQSPSGSPAPSQSLLRTSLLPLLKAAW CFLLHPHHLSQPHHHHLHPQLLLPLTKVDLQAK RPVRRPALGERNHPQPHSATPALNPAVVQSTPS PRDPRWTV*SASLHRQQNQGLPARRPYHLLQHPP SLENSIFLESTFLEFSNKGVCQQKPLF*VGVER TPWWNFLLLHPILIFHPLHLKQSFLCPPLRFQQ FSRETPLQKWQSLILNHNNGLKCQ*RRPLHPHDP NGMIAPASLKLRFLSSQQWPQLCHKCPPLPNPA LVSSLDSWLTSTGHCNESPSLGTAHSPPACPEQ NQQPPWMIWHCLHHPLNCCLINRRLVTEAVIYQA MQRCGEDPLLLPPKETRTPSSPETGSHHRTLFS *YL*SLLQSAHLIICEFRCSEPPGMMLFR*CPA ICVCVCVHVHVHTAVQCVYICIHICMCMCI*RES *ELFYLFLFSPNLKMGVLYFGWKRHRRGCVLSL KISISCGLDQKLLITYLEGIYKCLSMCSLFVHV VYYITKE*M*NVLFLVEKNHQNVWCIYKAFVFVF PQLAEVRIA*LTLHCYT*RGTLNQENLSAS*NG *LVQDGEMFTDIICMWLCIESKYMA*LTQLF*L QYCCSDPPTFRMC*QISSLPTIHG*LVL*FWIVP F*YCFMKLYQLGFMILTLIDFKRMDNTVISVMF CPSMSLGHQLPS*NMCFR*VLLHICRQLVYEIY TSCAPIWCIMKNKIIF*NAFFEHCSIEGKGDERT ELAPVQVSLIWLYMGYNM*YKKLIKYGTTWRGK TVSFIATGATRTLADCSLVVISSGY*VF*WSGT VQVQ*LTLRFMRVQFGITWSQCSNDTLYFYMLFS VNFPWYMREISTLINL**IGLLGIKQSQSSS*T RE*KWAIPALIRGAHLVMKVCAYC**LPMQTAE IS*HCPTRKK*CQ*SGGRDGK*F*NEQKCLISTV YSRSCITHTPRKPHRKQRVNSTSPLLHLQNIVR LCSCGYGAIRIYTINF*VFQIVHQVLCLIFMK* SLTHLHC*FKHAQKFG*CLSRLPSATVIHE*ISH SLLPAVL*FEGHPYLWVRVSKNMNPVIKVFIPE VLSFIVVVIFS*EGRQHFSFS*GGKNVPANLFS PMI*ALKQQPLCFQCRISWNFLLVSILMIAILNR CFWSVFLE*QTSF*TLMMPGRE*G*RRRLILTP VQWLVRQQAISLYIPPQTEMAIKNVLTSCMN*I *KTTKVILYTSVLLPSGFSLIWIFVGM*LFLDCI SVALFLWCIHGKHLLPHDTSTVPSFTALCSAAL TQLGCFKSVQLTWLY*KVNSMD*LILLLRAVQT GAY*R**LA*LVTLLISTMDNFKVESLYA*SFGT NAVGQQNLFSVK*LMVY*IFCIGFYQLDFYCSD AFFPPLRRCNSLGKSNYS*GFYRYPP*L*IG*F IFLGLFK*KCGMLSYKRLFIRKFQTK*TWRFIVL *NLGAPTHQRHILQRAVNYLGELSWVPFPCMFS CH*KQTTLSLSRKFKLGDHNNSNQVTTLTSRLL GAVHPIQVLFAAILGE*TCIWRIN**TCIEEIHK VIN*PEKYFR*WCGLACFDSQPPTEIFVTFVPQ LKVILL*TQSDFKQVKNPFLFLYITKSFSYTYR AN*LQLI*STQV*TS*THRILYGYQCDALLFIK* V*LGHTLDERVTVSRGRKPFRLQVTFTFFFLIY TLHLYKLCRVLLTL*KCMTSHKVEI*SKEKCKY KRIRYLLSFKVFFFFW*RWGSHCVAQAGLKLLAT SDLPASASQNAEITGMSHCTQPFLIKFKEKIST PLSLK*NKCSVLTVPLQGLYVKEI*NLAVE*NL INKKKKHTFLQLVCSLLVEVINRFKEKILAVNPQ CLQLFWQNIFKEIQQANFEVLMKVKEGGISSFG RNEKCLTRDITTHVGSGCFLPKTFREVN*VRVM VNTTYFIDG*VEN*LCLSWMATNTKLMIVAASTS *AVKLVCSTKGGETLIFCKLSIR*IYCNLIPKT AVFHIISPPPTFFFFFATCKITPSRK*ALTGMF QTILLHFTISH**TLTEMYI*DKISLC*VF*KHC LLLKGNCTLYLTGIAPSLSSLKNKSQGSHQLVG CGSFAIGRYNVEVYFFKA*RRQGTSL*CTR*RT LLFKGLCTAQ*R*SYNFSRSFVAIIFFCINVCSF HYVPCSLIVQSYIYIYIYIDR*IDI*ERYIQYY *GCFSEDVFVLLD*VIFQVTLASYVSKLL*WLS TLVVQSV*MFFIYMFSLYQLIKSLIKKIHRFHL

Frame 2

GRPAPAPAAARQSVSQSVSQSVSQSLSARRGSC WQSLRLWRGSAAPGEEAEAAAGGARAAVSLPGA AGRPTDCRDGAAIR*RN*SWC*RRQ*QGRSGPG QNVWSLAWRTRQTHSEFGF*QAHGTSKKISSSPG NKHGQLFLPLLHIQLE*SSESGRDCGSGCLDG* SLLYRAGAQQHWFRKQ*ASNHRNESYSEIAC*P TYIETWHLERIIFFI**DS*TFPCQLLLGRRHCT VRTGLFEYG*GCSAICTRRY*TLSN*SAQKNRV SRHSE*C*STLY**FLPFQHHFRSLQHGLFGY* *SNTPSRAGFDTSRAANY*GRTGSKIES*EDQSC PREN*RGTSEKAGDQSPHV**QF*NNDGG*EAD SKTSTG*PDGQIPLRL*FRLVTGRNRF*ITNGE NL*RP*KLG*KSS*LDKR*PKQAYIYGAYRKICT FQKPTELSFGEKRNS*DGR*KQRSPLGGMFLWK FCNCTRN*RSPLVEG*WQEVLEKALFSLASIWY LLCSQRKSKGLSGSGVLSPAGSCQRLLWPGLSEQ IQSTYRLLSGAEASTNPEEISIYQIPLL**CED TASVGQWDPHCKVWEAALYELPRSLEEDRVSL* LDFLIQLQH*IGIQFFQHPRVSVKPLQSV**RSF *HPASRTRPFPEHCELRIL*SLETRHSVGRVQQ GQNGVYESALHFTCAPFIPAT*DSHPLHCFTAF TTSTSSATPTSSSTTPSTTPSSPTPQPVCTFCRL SSPNVRQVQHNNTATECVSAFRGPV*AANTPSD AVTVSEASDPGTPQWSCSTTPSPSSTPNPRLCH GPAKACTVCPIPSTVQCPASSTEDPSSSAYYSGG SPNTPPTSSYPCTPPSPSSPKTPCDHPRTNQHQ DCGTCCDSSCTTHTYSSSAPSKKAASFPCFLHS TLSPYPSCSSTPANITQATELLCKTPSLSTVTGA LGREADSQPVSTPSNSPCHGISALKACPSKCSS TVPSCSKSKAQVAAQLHPSPFSGLPSSPS*KQP GVSSSTPITCPSPTTTTSTHSFSYP*QKWISRQK DQ*DVQPWGKETTPNPTAQLQH*IQQWCRAPRA QETLGGQSSQQVYTASRIRVSQQGDPTTSCSTP QAWKTQSFWSQPSWSSPTRVCVSKSPCSEWAWKG LRGGISFSSIRF*FSTPST*NRASSAPH*DSSS FLGKHLSKSGSR*SSTTTMV*NVSEEGPSTHTT QTE**HPPHSS*DF*AANNGHSCATSAHLSQIQP *CPAWIPG*PQQDTATKVHHSARLTLLPHVQSR TNSHHG*YGIASTTP*TAV*STEGWLRRQSYIR LCNVAERTPSCSPQKRPEHQALQRLVATIGLYFH DICNHCYNQLT*SSVNSGVQSLLV*CYSGSVQL YVYVCVYTCMYTQLYSVCIYVYIYVCVCVYRER AESYSIYSFSLLI*KWVFCILGGRGIEGDVCCLL RFLYHVDWTKNF*SLI*KVFISVCPCVAYSCML CII*LRNRCRMCYFWLRKITRMFGVSIRLLCLF FPSWLKLELLD*HFIAIHEGAL*IRKISQLHRTG N*CRMGKCSQTSSVCGCA*KVNTWRN*LSCSSC STAAVIHPHLGCADR*ALCLQYMDN*CYNSG*F LFSTVL*SFINLAS*SSL*LILRGWITQLSL*CS VPVCLWVTSYLLKICALGRCYYISVDNWYMKYT HPVPQYGAL*KTKSFSKMHFLSIAL*KGRVMRE QNWPLYRCH*SGCIWVIICNTKSSLSMGLHGEGR QFHL*LLGLPGPLLTAAWL*LVQVTRCSDGVGQ SKSSN*HYVLCVCSLV*RGVSALTTHYTSICFF L*IFLGT*EK*VLSSTYDKLDY*E*NNLRAAPKQ ENKNGPSQHL*GEHIL**KSVPIVNDYQCKLQK SVDIVPQGKSDASKVGEEMVNNSRMSKSA*LVQ YTQGLA*PTLHENRIVNRE*TAPLHCYISRILFG YVHVVMEQ*EYIPLIFRSFKLFTKFCV*YL*SD L*HICIVNLSMHRNLGNV*VDCQALL*FMNEFL IVFCLQFYSLRGTHICGLELVRI*IQLSKYSSLR F*VLLWW*FSHEKVDNTSVFLEGEKMYPLTFFH P*FEP*NNSLYVFSAGFLGISCLYQS***PS*T DASGLFSWNSRHPFEH**CQEESKARGGDSF*PQ SSGLSDNRPFPFTFLHRQKWLLKMF*PHV*TEF KKPLK*YFILLFYSLVGFL*FGFLLGCSFS*TV FL*LFFSGVFMESIYCRTTLVLCLLSLPSALQLS PSLAASSLCS*LGCTEK*TAWINSSCC*GQCKQ VLIRGSDLLN**HS*FLLWIISK*NHSMLRVLA PML*GSRIYSQ*NNLWFIRYSVLDFTSLTFTAQM LSFPPLDAVILLGRVTILKVFTDTHLSCKLDSL YFWDFLNENVEC*VTKDFSSENFKQSKHGVL*S SKI*VLPPTKGISCKGL*TILVNCLGSPFHVCFL VTENKQR*VYQENLNWGIIIIPTK*QL*HQGY* ELYIQFKFYLLLFWENKLVYGE*TNKLVSRKSI KL*ISLKNISGNGVDWPALTLSHQQKSLSPLFLS *K*FCYKHKVTLNR*KTHSYFCTLPKVFHIPTE LTNYN*FNPLKFRPVKPIGSCMVINVMPCFS*N RYNWVIHLTRG*LFLGEENPLDCR*LSLFFF*YT LYICINYAGYS*PCRNV*PLTKLRFDPKRNASI KELDTYYLLRFFFFFGRDGGLTVLPRLVSNSWP QVIFLPQPPKMLRLQA*ATVPSLSL*NSKRKFLH LYPSNKTSAQFLPCPCKVYM*KKSEI*L*NKT* *IKRKNIHFSSWFALCLLK**TVLKRKYLL*TP SAFNSFGRIFLKKSSKQTLRC**K*RKVVFLVLA EMKSVSQETSLPTWGLAAFYQRHLEK*IESG*W *TLHIL*MVKLRINYVYHGWLLIPSS*LLQPQR LRQ*NLSAALKGEKPLYFANCPFVKFIVT*YQKL PFFILFPHLLLFFFFLLLVK*PLLENKH*LECF KQFCFILLSATSELLQRCTFKIKLACAKCFKNI VYC*RGIAHYI*LGLLPPSVL*KTRVKAHTNL*A VGALP*VDTM*KYTFLKHEEDKELHYNVPGRGH YYSKDYAQLSEDEVTIFLAALLLLFSSA*MYAH FIMCLAP*LCKAIYIYIYI*IDR*IYERDIFSTT EDVFLRMFLFCWIKLFSKLLLPVMSVNYCNGLA H*SYSQCKCFSFTCFHYISLSNP**KKFIDFI*

Sequence NM_213589

Frame 0

Frame 1

Frame 2

Sequence NM_025252

Frame 0

Frame 1

Frame 2

Sequence NM_203365

Frame 0

Frame 1

Frame 2